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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AIM1-ARMC2 (FusionGDB2 ID:HG51151TG84071)

Fusion Gene Summary for AIM1-ARMC2

check button Fusion gene summary
Fusion gene informationFusion gene name: AIM1-ARMC2
Fusion gene ID: hg51151tg84071
HgeneTgene
Gene symbol

AIM1

ARMC2

Gene ID

51151

84071

Gene namesolute carrier family 45 member 2armadillo repeat containing 2
Synonyms1A1|AIM1|MATP|OCA4|SHEP5SPGF38|bA787I22.1
Cytomap('AIM1')('ARMC2')

5p13.2

6q21

Type of geneprotein-codingprotein-coding
Descriptionmembrane-associated transporter proteinmelanoma antigen AIM1protein AIM-1underwhitearmadillo repeat-containing protein 2
Modification date2020031320200313
UniProtAcc.

Q8NEN0

Ensembl transtripts involved in fusion geneENST00000487681, ENST00000369066, 
ENST00000535438, 
Fusion gene scores* DoF score9 X 8 X 4=28815 X 15 X 7=1575
# samples 916
** MAII scorelog2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/1575*10)=-3.29920801838728
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AIM1 [Title/Abstract] AND ARMC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAIM1(106992572)-ARMC2(109294560), # samples:3
Anticipated loss of major functional domain due to fusion event.AIM1-ARMC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AIM1-ARMC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AIM1-ARMC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AIM1-ARMC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AIM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ARMC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0TP-01AAIM1chr6

106992572

-ARMC2chr6

109294560

+
ChimerDB4BRCATCGA-AR-A0TP-01AAIM1chr6

106992572

+ARMC2chr6

109294560

+
ChimerDB4BRCATCGA-AR-A0TP-01AAIM1chr6

106992808

+ARMC2chr6

109294560

+


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Fusion Gene ORF analysis for AIM1-ARMC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000487681ENST00000368972AIM1chr6

106992572

+ARMC2chr6

109294560

+
3UTR-3CDSENST00000487681ENST00000368972AIM1chr6

106992808

+ARMC2chr6

109294560

+
3UTR-3CDSENST00000487681ENST00000392644AIM1chr6

106992572

+ARMC2chr6

109294560

+
3UTR-3CDSENST00000487681ENST00000392644AIM1chr6

106992808

+ARMC2chr6

109294560

+
3UTR-intronENST00000487681ENST00000481850AIM1chr6

106992572

+ARMC2chr6

109294560

+
3UTR-intronENST00000487681ENST00000481850AIM1chr6

106992808

+ARMC2chr6

109294560

+
5CDS-intronENST00000369066ENST00000481850AIM1chr6

106992572

+ARMC2chr6

109294560

+
5CDS-intronENST00000369066ENST00000481850AIM1chr6

106992808

+ARMC2chr6

109294560

+
5CDS-intronENST00000535438ENST00000481850AIM1chr6

106992572

+ARMC2chr6

109294560

+
5CDS-intronENST00000535438ENST00000481850AIM1chr6

106992808

+ARMC2chr6

109294560

+
Frame-shiftENST00000369066ENST00000368972AIM1chr6

106992572

+ARMC2chr6

109294560

+
Frame-shiftENST00000369066ENST00000392644AIM1chr6

106992572

+ARMC2chr6

109294560

+
Frame-shiftENST00000535438ENST00000368972AIM1chr6

106992572

+ARMC2chr6

109294560

+
Frame-shiftENST00000535438ENST00000392644AIM1chr6

106992572

+ARMC2chr6

109294560

+
In-frameENST00000369066ENST00000368972AIM1chr6

106992808

+ARMC2chr6

109294560

+
In-frameENST00000369066ENST00000392644AIM1chr6

106992808

+ARMC2chr6

109294560

+
In-frameENST00000535438ENST00000368972AIM1chr6

106992808

+ARMC2chr6

109294560

+
In-frameENST00000535438ENST00000392644AIM1chr6

106992808

+ARMC2chr6

109294560

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000369066AIM1chr6106992808+ENST00000368972ARMC2chr6109294560+500145752545781517
ENST00000369066AIM1chr6106992808+ENST00000392644ARMC2chr6109294560+520245752545781517
ENST00000535438AIM1chr6106992808+ENST00000368972ARMC2chr6109294560+103560964612182
ENST00000535438AIM1chr6106992808+ENST00000392644ARMC2chr6109294560+123660964612182

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369066ENST00000368972AIM1chr6106992808+ARMC2chr6109294560+0.0007931840.99920684
ENST00000369066ENST00000392644AIM1chr6106992808+ARMC2chr6109294560+0.0006790260.999321
ENST00000535438ENST00000368972AIM1chr6106992808+ARMC2chr6109294560+0.0041630190.995837
ENST00000535438ENST00000392644AIM1chr6106992808+ARMC2chr6109294560+0.0028222170.99717784

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Fusion Genomic Features for AIM1-ARMC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AIM1chr6106992808+ARMC2chr6109294559+1.10E-050.99998903
AIM1chr6106992572+ARMC2chr6109294559+3.35E-060.99999666
AIM1chr6106992808+ARMC2chr6109294559+1.10E-050.99998903
AIM1chr6106992572+ARMC2chr6109294559+3.35E-060.99999666

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AIM1-ARMC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:106992572/chr6:109294560)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARMC2

Q8NEN0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity). {ECO:0000250|UniProtKB:Q3URY6}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAIM1chr6:106992808chr6:109294560ENST00000369066+11201022_106113621724.0DomainBeta/gamma crystallin 'Greek key' 1
HgeneAIM1chr6:106992808chr6:109294560ENST00000369066+11201062_111713621724.0DomainBeta/gamma crystallin 'Greek key' 2
HgeneAIM1chr6:106992808chr6:109294560ENST00000369066+11201123_116313621724.0DomainBeta/gamma crystallin 'Greek key' 3
HgeneAIM1chr6:106992808chr6:109294560ENST00000369066+11201164_120613621724.0DomainBeta/gamma crystallin 'Greek key' 4
HgeneAIM1chr6:106992808chr6:109294560ENST00000369066+11201218_127013621724.0DomainBeta/gamma crystallin 'Greek key' 5
HgeneAIM1chr6:106992808chr6:109294560ENST00000369066+11201271_131313621724.0DomainBeta/gamma crystallin 'Greek key' 6
HgeneAIM1chr6:106992808chr6:109294560ENST00000369066+11201319_136113621724.0DomainBeta/gamma crystallin 'Greek key' 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAIM1chr6:106992808chr6:109294560ENST00000369066+11201362_140413621724.0DomainBeta/gamma crystallin 'Greek key' 8
HgeneAIM1chr6:106992808chr6:109294560ENST00000369066+11201415_145213621724.0DomainBeta/gamma crystallin 'Greek key' 9
HgeneAIM1chr6:106992808chr6:109294560ENST00000369066+11201453_149613621724.0DomainBeta/gamma crystallin 'Greek key' 10
HgeneAIM1chr6:106992808chr6:109294560ENST00000369066+11201502_154213621724.0DomainBeta/gamma crystallin 'Greek key' 11
HgeneAIM1chr6:106992808chr6:109294560ENST00000369066+11201543_158413621724.0DomainBeta/gamma crystallin 'Greek key' 12
HgeneAIM1chr6:106992808chr6:109294560ENST00000369066+11201586_171913621724.0DomainRicin B-type lectin
TgeneARMC2chr6:106992808chr6:109294560ENST000003926441618262_301815868.0RepeatNote=ARM 1
TgeneARMC2chr6:106992808chr6:109294560ENST000003926441618304_344815868.0RepeatNote=ARM 2
TgeneARMC2chr6:106992808chr6:109294560ENST000003926441618363_403815868.0RepeatNote=ARM 3
TgeneARMC2chr6:106992808chr6:109294560ENST000003926441618408_449815868.0RepeatNote=ARM 4
TgeneARMC2chr6:106992808chr6:109294560ENST000003926441618462_503815868.0RepeatNote=ARM 5
TgeneARMC2chr6:106992808chr6:109294560ENST000003926441618506_547815868.0RepeatNote=ARM 6
TgeneARMC2chr6:106992808chr6:109294560ENST000003926441618551_589815868.0RepeatNote=ARM 7
TgeneARMC2chr6:106992808chr6:109294560ENST000003926441618591_616815868.0RepeatNote=ARM 8
TgeneARMC2chr6:106992808chr6:109294560ENST000003926441618619_662815868.0RepeatNote=ARM 9
TgeneARMC2chr6:106992808chr6:109294560ENST000003926441618664_705815868.0RepeatNote=ARM 10
TgeneARMC2chr6:106992808chr6:109294560ENST000003926441618707_746815868.0RepeatNote=ARM 11
TgeneARMC2chr6:106992808chr6:109294560ENST000003926441618748_790815868.0RepeatNote=ARM 12


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Fusion Gene Sequence for AIM1-ARMC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3194_3194_1_AIM1-ARMC2_AIM1_chr6_106992808_ENST00000369066_ARMC2_chr6_109294560_ENST00000368972_length(transcript)=5001nt_BP=4575nt
AGATGCCACCACCACTGCCAAGCAGCTGCATTCCTCGCCGGGAAATTCCTCCAGGCAAGAGAACGCAGAGACGCCCGCCCGCAGTCCGGG
GGAGGACGCTTCACCAGGTGCTGGCCACGAACAGGAGGCTTTCCTGGGTGTGAGGGGTGCGCCAGGGTCGCCCACCCAGGAGCGGCCCGC
GGGAGGACTAGGCGAGGCCCCTAACGGAGCCCCCAGTGTGTGTGCCGAAGAAGGCTCCCTGGGGCCCCGCAACGCCCGCAGCCAGCCCCC
CAAGGGCGCGTCTGATTTGCCAGGTGAGCCTCCGGCCGAGGGCGCAGCGCACACGGCCAGCTCCGCGCAGGCAGACTGCACAGCCCGCCC
CAAGGGTCACGCCCACCCTGCTAAGGTGCTAACTTTGGACATCTACTTGAGTAAGACTGAGGGGGCACAAGTGGACGAGCCGGTCGTGAT
TACTCCCAGAGCGGAAGATTGCGGTGACTGGGACGACATGGAGAAGAGGTCCAGCGGCCGTAGGTCGGGGAGGCGGAGGGGGTCGCAGAA
ATCCACCGACTCCCCCGGCGCGGACGCCGAGCTCCCTGAGAGCGCTGCCAGGGACGACGCGGTGTTCGACGACGAGGTGGCGCCAAACGC
GGCCAGCGATAACGCCTCGGCGGAAAAGAAAGTGAAATCTCCGCGGGCAGCCCTCGACGGGGGCGTTGCCTCCGCTGCGAGCCCAGAGTC
CAAGCCCAGCCCCGGTACCAAAGGGCAGCTCCGAGGGGAGTCGGACCGGAGCAAACAGCCACCCCCGGCTTCGTCCCCCACGAAGAGGAA
GGGCAGGAGCCGTGCCCTCGAGGCCGTGCCCGCCCCGCCCGCCAGCGGCCCCCGGGCTCCCGCCAAGGAGTCCCCACCCAAGAGGGTGCC
CGATCCCAGCCCAGTCACCAAGGGCACTGCGGCCGAGAGCGGGGAGGAGGCGGCGCGGGCCATCCCCCGCGAGCTCCCGGTCAAGAGCAG
CTCGCTGCTGCCGGAGATCAAGCCCGAGCACAAGAGGGGCCCGCTCCCCAACCACTTCAACGGCCGGGCAGAGGGAGGTCGAAGCAGAGA
GCTGGGCAGAGCGGCCGGAGCGCCTGGAGCTTCTGACGCCGACGGCTTGAAGCCCAGGAACCATTTCGGCGTGGGCAGGTCGACAGTGAC
CACTAAAGTGACCCTCCCTGCCAAGCCCAAACATGTGGAACTAAATCTTAAAACCCCTAAGAATCTTGACAGTTTGGGAAATGAGCACAA
TCCATTTAGCCAGCCAGTTCACAAAGGCAACACTGCCACCAAAATCTCCTTATTTGAAAACAAACGGACAAACAGTAGCCCAAGACACAC
TGACATTCGAGGCCAAAGGAATACTCCTGCCTCTAGTAAAACGTTTGTTGGGAGGGCAAAGCTGAATTTAGCCAAAAAAGCCAAAGAAAT
GGAGCAACCTGAAAAGAAAGTAATGCCAAACAGTCCCCAGAATGGTGTGCTGGTTAAGGAAACTGCTATAGAAACCAAAGTTACCGTCTC
GGAAGAAGAGATTCTGCCAGCAACCAGAGGAATGAATGGAGACTCTTCTGAGAATCAAGCTCTTGGTCCTCAGCCTAACCAAGATGATAA
AGCAGATGTACAAACAGATGCTGGCTGCCTTTCAGAACCAGTGGCTTCTGCTCTGATTCCTGTCAAGGATCATAAGCTCTTAGAGAAGGA
GGACTCAGAGGCTGCAGACAGCAAAAGCCTTGTACTTGAAAATGTAACCGATACAGCACAAGACATCCCCACCACTGTGGATACCAAAGA
TTTACCTCCAACGGCCATGCCAAAGCCACAGCATACATTTTCTGACTCACAGTCCCCTGCTGAGTCATCTCCTGGGCCTTCTCTTTCACT
GTCTGCACCCGCTCCTGGGGATGTTCCCAAAGACACATGTGTTCAATCACCCATAAGCAGTTTCCCATGCACTGATCTAAAAGTGTCAGA
AAACCATAAAGGATGTGTTTTGCCTGTGTCTCGTCAGAACAATGAGAAAATGCCACTTTTAGAACTTGGAGGAGAAACAACCCCTCCTTT
GTCCACAGAGCGTAGTCCAGAAGCTGTGGGAAGTGAGTGTCCATCCAGAGTCCTCGTCCAGGTCAGGTCCTTCGTGCTCCCCGTGGAGAG
CACCCAGGATGTGAGCTCCCAGGTCATCCCAGAGAGCTCTGAAGTTAGAGAAGTGCAGTTGCCAACTTGTCACAGTAATGAACCTGAAGT
GGTTTCCGTTGCAAGTTGTGCTCCCCCACAAGAGGAAGTACTGGGCAATGAACACTCTCATTGCACAGCAGAGCTCGCGGCAAAATCTGG
CCCACAAGTCATACCGCCAGCATCAGAGAAAACTCTGCCTATTCAGGCTCAAAGTCAGGGCAGCAGAACACCCCTGATGGCTGAATCCAG
TCCCACCAACTCTCCCAGCAGCGGAAATCACTTAGCCACTCCTCAAAGGCCAGATCAGACTGTTACAAATGGCCAGGATAGCCCTGCCAG
CCTTTTGAACATTTCTGCTGGTAGTGATGATAGTGTATTTGATTCTTCTTCTGATATGGAAAAATTCACTGAAATTATAAAACAGATGGA
TAGCGCAGTTTGTATGCCCATGAAAAGAAAGAAGGCCAGGATGCCAAACTCTCCTGCTCCTCACTTTGCCATGCCTCCTATTCACGAAGA
CCATTTAGAAAAGGTGTTTGATCCCAAAGTGTTTACCTTTGGTTTGGGGAAGAAGAAGGAAAGTCAGCCAGAAATGTCACCGGCTTTACA
TTTGATGCAGAACCTTGACACAAAATCCAAACTGAGACCCAAACGTGCATCTGCTGAACAGAGCGTCCTCTTCAAGTCCCTGCACACCAA
CACTAATGGGAACAGTGAGCCTCTGGTGATGCCGGAAATCAATGACAAAGAGAACAGGGACGTCACAAATGGTGGCATTAAGAGATCGAG
ACTAGAAAAAAGTGCACTTTTCTCAAGCTTGTTATCTTCTTTACCACAAGACAAAATCTTTTCTCCTTCTGTGACATCAGTCAACACTAT
GACCACGGCTTTCAGTACTTCTCAGAACGGTTCCCTATCTCAGTCTTCAGTGTCACAGCCCACGACTGAGGGTGCCCCGCCCTGTGGTTT
GAACAAAGAACAGTCAAATCTTCTGCCCGACAACTCCTTAAAGGTCTTCAATTTCAACTCGTCAAGTACATCACACTCCAGTTTGAAAAG
TCCAAGCCACATGGAAAAATACCCGCAAAAAGAGAAAACCAAAGAAGATCTGGATTCACGAAGCAACCTACACTTGCCAGAAACTAAATT
TTCTGAATTGTCAAAACTGAAGAATGATGATATGGAAAAGGCTAATCATATTGAAAGTGTTATTAAATCAAACTTGCCAAACTGTGCAAA
CAGTGACACCGACTTCATGGGTCTTTTCAAATCAAGCCGGTATGACCCAAGCATTTCTTTTTCTGGAATGTCATTATCAGACACAATGAC
ACTTAGAGGAAGTGTCCAAAATAAACTCAATCCCCGACCTGGAAAGGTAGTGATATATAGTGAACCCGACGTCTCTGAGAAGTGCATTGA
AGTTTTCAGTGACATTCAGGATTGCAGTTCTTGGAGCCTCTCTCCAGTGATACTCATAAAAGTTGTTAGAGGATGTTGGATTTTGTATGA
GCAACCAAATTTTGAAGGGCACTCCATCCCCTTAGAAGAAGGAGAATTGGAACTCTCTGGTCTCTGGGGTATAGAAGACATTTTGGAAAG
GCACGAAGAAGCAGAGTCTGATAAGCCAGTGGTGATTGGTTCCATCAGACATGTGGTTCAGGATTACAGAGTTAGTCACATTGACTTATT
TACTGAACCAGAAGGGTTAGGAATCCTAAGTTCCTACTTTGATGATACTGAAGAAATGCAGGGATTTGGTGTAATGCAGAAGACTTGTTC
CATGAAAGTACATTGGGGCACGTGGCTGATTTATGAAGAACCTGGATTTCAGGGTGTTCCTTTCATCCTGGAACCTGGTGAATACCCTGA
CTTGTCCTTCTGGGATACAGAAGAAGCGTACATTGGATCCATGCGGCCTCTGAAAATGGGTGGCCGTAAAGTTGAATTCCCTACAGATCC
AAAGGTAGTTGTTTATGAAAAGCCTTTCTTTGAAGGAAAATGTGTGGAACTAGAAACAGGAATGTGTAGTTTTGTCATGGAGGGAGGTGA
AACAGAAGAGGCGACTGGAGACGATCATTTGCCGTTTACGTCAGTGGGGTCTATGAAAGTTCTAAGAGGCATTTGGGTTGCATATGAGAA
ACCTGGATTTACCGGTCATCAGTATTTGCTAGAAGAAGGAGAATACAGGGACTGGAAAGCCTGGGGAGGTTACAATGGAGAGCTTCAGTC
TTTACGACCTATATTAGGTGATTTTTCAAATGCTCACATGATAATGTACAGTGAAAAAAACTTTGGATCCAAAGGTTCCAGTATTGATGT
ATTGGGAATTGTTGCTAATTTAAAGGAGACTGGATATGGAGTGAAGACACAGTCTATTAATGTACTGAGTGGAGTATGAAGAACTAGCAC
TGGATGGCAGTTTTGATCCAGACCTAAAAAACTATCACAAACTCCATTGGGAAACAGAATTCAAACCTGTGGCACAGCAGCTTCTAAACC
GAATTCAGAGACATCACACCTTCCTGGAACCCCTGCCCATTCCCTCTTTCTAACATGATGCAGATTAACAGTAGAAACGAGAACTCACGT
CTCCCTCATTCTTAAGAACTGGTAACAAACGTGAACATTTTTTTCAGCATTAACAAATGTGGAAAGTTTTTCAAGAACTGGTTTTAGTGA
GTAGCTGAAGTATTTTTTAAAATTAAGCATTTCTTCTTGTTAGGTATTATGGAAAAATGAATATACACATTATATTTCCTGTTGAGAGAA

>3194_3194_1_AIM1-ARMC2_AIM1_chr6_106992808_ENST00000369066_ARMC2_chr6_109294560_ENST00000368972_length(amino acids)=1517AA_BP=
MHSSPGNSSRQENAETPARSPGEDASPGAGHEQEAFLGVRGAPGSPTQERPAGGLGEAPNGAPSVCAEEGSLGPRNARSQPPKGASDLPG
EPPAEGAAHTASSAQADCTARPKGHAHPAKVLTLDIYLSKTEGAQVDEPVVITPRAEDCGDWDDMEKRSSGRRSGRRRGSQKSTDSPGAD
AELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRAALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEA
VPAPPASGPRAPAKESPPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHKRGPLPNHFNGRAEGGRSRELGRAAGAP
GASDADGLKPRNHFGVGRSTVTTKVTLPAKPKHVELNLKTPKNLDSLGNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNT
PASSKTFVGRAKLNLAKKAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEILPATRGMNGDSSENQALGPQPNQDDKADVQTDAG
CLSEPVASALIPVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIPTTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDV
PKDTCVQSPISSFPCTDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVRSFVLPVESTQDVSSQV
IPESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTAELAAKSGPQVIPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSG
NHLATPQRPDQTVTNGQDSPASLLNISAGSDDSVFDSSSDMEKFTEIIKQMDSAVCMPMKRKKARMPNSPAPHFAMPPIHEDHLEKVFDP
KVFTFGLGKKKESQPEMSPALHLMQNLDTKSKLRPKRASAEQSVLFKSLHTNTNGNSEPLVMPEINDKENRDVTNGGIKRSRLEKSALFS
SLLSSLPQDKIFSPSVTSVNTMTTAFSTSQNGSLSQSSVSQPTTEGAPPCGLNKEQSNLLPDNSLKVFNFNSSSTSHSSLKSPSHMEKYP
QKEKTKEDLDSRSNLHLPETKFSELSKLKNDDMEKANHIESVIKSNLPNCANSDTDFMGLFKSSRYDPSISFSGMSLSDTMTLRGSVQNK
LNPRPGKVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRGCWILYEQPNFEGHSIPLEEGELELSGLWGIEDILERHEEAESDK
PVVIGSIRHVVQDYRVSHIDLFTEPEGLGILSSYFDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEE
AYIGSMRPLKMGGRKVEFPTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEKPGFTGHQY

--------------------------------------------------------------
>3194_3194_2_AIM1-ARMC2_AIM1_chr6_106992808_ENST00000369066_ARMC2_chr6_109294560_ENST00000392644_length(transcript)=5202nt_BP=4575nt
AGATGCCACCACCACTGCCAAGCAGCTGCATTCCTCGCCGGGAAATTCCTCCAGGCAAGAGAACGCAGAGACGCCCGCCCGCAGTCCGGG
GGAGGACGCTTCACCAGGTGCTGGCCACGAACAGGAGGCTTTCCTGGGTGTGAGGGGTGCGCCAGGGTCGCCCACCCAGGAGCGGCCCGC
GGGAGGACTAGGCGAGGCCCCTAACGGAGCCCCCAGTGTGTGTGCCGAAGAAGGCTCCCTGGGGCCCCGCAACGCCCGCAGCCAGCCCCC
CAAGGGCGCGTCTGATTTGCCAGGTGAGCCTCCGGCCGAGGGCGCAGCGCACACGGCCAGCTCCGCGCAGGCAGACTGCACAGCCCGCCC
CAAGGGTCACGCCCACCCTGCTAAGGTGCTAACTTTGGACATCTACTTGAGTAAGACTGAGGGGGCACAAGTGGACGAGCCGGTCGTGAT
TACTCCCAGAGCGGAAGATTGCGGTGACTGGGACGACATGGAGAAGAGGTCCAGCGGCCGTAGGTCGGGGAGGCGGAGGGGGTCGCAGAA
ATCCACCGACTCCCCCGGCGCGGACGCCGAGCTCCCTGAGAGCGCTGCCAGGGACGACGCGGTGTTCGACGACGAGGTGGCGCCAAACGC
GGCCAGCGATAACGCCTCGGCGGAAAAGAAAGTGAAATCTCCGCGGGCAGCCCTCGACGGGGGCGTTGCCTCCGCTGCGAGCCCAGAGTC
CAAGCCCAGCCCCGGTACCAAAGGGCAGCTCCGAGGGGAGTCGGACCGGAGCAAACAGCCACCCCCGGCTTCGTCCCCCACGAAGAGGAA
GGGCAGGAGCCGTGCCCTCGAGGCCGTGCCCGCCCCGCCCGCCAGCGGCCCCCGGGCTCCCGCCAAGGAGTCCCCACCCAAGAGGGTGCC
CGATCCCAGCCCAGTCACCAAGGGCACTGCGGCCGAGAGCGGGGAGGAGGCGGCGCGGGCCATCCCCCGCGAGCTCCCGGTCAAGAGCAG
CTCGCTGCTGCCGGAGATCAAGCCCGAGCACAAGAGGGGCCCGCTCCCCAACCACTTCAACGGCCGGGCAGAGGGAGGTCGAAGCAGAGA
GCTGGGCAGAGCGGCCGGAGCGCCTGGAGCTTCTGACGCCGACGGCTTGAAGCCCAGGAACCATTTCGGCGTGGGCAGGTCGACAGTGAC
CACTAAAGTGACCCTCCCTGCCAAGCCCAAACATGTGGAACTAAATCTTAAAACCCCTAAGAATCTTGACAGTTTGGGAAATGAGCACAA
TCCATTTAGCCAGCCAGTTCACAAAGGCAACACTGCCACCAAAATCTCCTTATTTGAAAACAAACGGACAAACAGTAGCCCAAGACACAC
TGACATTCGAGGCCAAAGGAATACTCCTGCCTCTAGTAAAACGTTTGTTGGGAGGGCAAAGCTGAATTTAGCCAAAAAAGCCAAAGAAAT
GGAGCAACCTGAAAAGAAAGTAATGCCAAACAGTCCCCAGAATGGTGTGCTGGTTAAGGAAACTGCTATAGAAACCAAAGTTACCGTCTC
GGAAGAAGAGATTCTGCCAGCAACCAGAGGAATGAATGGAGACTCTTCTGAGAATCAAGCTCTTGGTCCTCAGCCTAACCAAGATGATAA
AGCAGATGTACAAACAGATGCTGGCTGCCTTTCAGAACCAGTGGCTTCTGCTCTGATTCCTGTCAAGGATCATAAGCTCTTAGAGAAGGA
GGACTCAGAGGCTGCAGACAGCAAAAGCCTTGTACTTGAAAATGTAACCGATACAGCACAAGACATCCCCACCACTGTGGATACCAAAGA
TTTACCTCCAACGGCCATGCCAAAGCCACAGCATACATTTTCTGACTCACAGTCCCCTGCTGAGTCATCTCCTGGGCCTTCTCTTTCACT
GTCTGCACCCGCTCCTGGGGATGTTCCCAAAGACACATGTGTTCAATCACCCATAAGCAGTTTCCCATGCACTGATCTAAAAGTGTCAGA
AAACCATAAAGGATGTGTTTTGCCTGTGTCTCGTCAGAACAATGAGAAAATGCCACTTTTAGAACTTGGAGGAGAAACAACCCCTCCTTT
GTCCACAGAGCGTAGTCCAGAAGCTGTGGGAAGTGAGTGTCCATCCAGAGTCCTCGTCCAGGTCAGGTCCTTCGTGCTCCCCGTGGAGAG
CACCCAGGATGTGAGCTCCCAGGTCATCCCAGAGAGCTCTGAAGTTAGAGAAGTGCAGTTGCCAACTTGTCACAGTAATGAACCTGAAGT
GGTTTCCGTTGCAAGTTGTGCTCCCCCACAAGAGGAAGTACTGGGCAATGAACACTCTCATTGCACAGCAGAGCTCGCGGCAAAATCTGG
CCCACAAGTCATACCGCCAGCATCAGAGAAAACTCTGCCTATTCAGGCTCAAAGTCAGGGCAGCAGAACACCCCTGATGGCTGAATCCAG
TCCCACCAACTCTCCCAGCAGCGGAAATCACTTAGCCACTCCTCAAAGGCCAGATCAGACTGTTACAAATGGCCAGGATAGCCCTGCCAG
CCTTTTGAACATTTCTGCTGGTAGTGATGATAGTGTATTTGATTCTTCTTCTGATATGGAAAAATTCACTGAAATTATAAAACAGATGGA
TAGCGCAGTTTGTATGCCCATGAAAAGAAAGAAGGCCAGGATGCCAAACTCTCCTGCTCCTCACTTTGCCATGCCTCCTATTCACGAAGA
CCATTTAGAAAAGGTGTTTGATCCCAAAGTGTTTACCTTTGGTTTGGGGAAGAAGAAGGAAAGTCAGCCAGAAATGTCACCGGCTTTACA
TTTGATGCAGAACCTTGACACAAAATCCAAACTGAGACCCAAACGTGCATCTGCTGAACAGAGCGTCCTCTTCAAGTCCCTGCACACCAA
CACTAATGGGAACAGTGAGCCTCTGGTGATGCCGGAAATCAATGACAAAGAGAACAGGGACGTCACAAATGGTGGCATTAAGAGATCGAG
ACTAGAAAAAAGTGCACTTTTCTCAAGCTTGTTATCTTCTTTACCACAAGACAAAATCTTTTCTCCTTCTGTGACATCAGTCAACACTAT
GACCACGGCTTTCAGTACTTCTCAGAACGGTTCCCTATCTCAGTCTTCAGTGTCACAGCCCACGACTGAGGGTGCCCCGCCCTGTGGTTT
GAACAAAGAACAGTCAAATCTTCTGCCCGACAACTCCTTAAAGGTCTTCAATTTCAACTCGTCAAGTACATCACACTCCAGTTTGAAAAG
TCCAAGCCACATGGAAAAATACCCGCAAAAAGAGAAAACCAAAGAAGATCTGGATTCACGAAGCAACCTACACTTGCCAGAAACTAAATT
TTCTGAATTGTCAAAACTGAAGAATGATGATATGGAAAAGGCTAATCATATTGAAAGTGTTATTAAATCAAACTTGCCAAACTGTGCAAA
CAGTGACACCGACTTCATGGGTCTTTTCAAATCAAGCCGGTATGACCCAAGCATTTCTTTTTCTGGAATGTCATTATCAGACACAATGAC
ACTTAGAGGAAGTGTCCAAAATAAACTCAATCCCCGACCTGGAAAGGTAGTGATATATAGTGAACCCGACGTCTCTGAGAAGTGCATTGA
AGTTTTCAGTGACATTCAGGATTGCAGTTCTTGGAGCCTCTCTCCAGTGATACTCATAAAAGTTGTTAGAGGATGTTGGATTTTGTATGA
GCAACCAAATTTTGAAGGGCACTCCATCCCCTTAGAAGAAGGAGAATTGGAACTCTCTGGTCTCTGGGGTATAGAAGACATTTTGGAAAG
GCACGAAGAAGCAGAGTCTGATAAGCCAGTGGTGATTGGTTCCATCAGACATGTGGTTCAGGATTACAGAGTTAGTCACATTGACTTATT
TACTGAACCAGAAGGGTTAGGAATCCTAAGTTCCTACTTTGATGATACTGAAGAAATGCAGGGATTTGGTGTAATGCAGAAGACTTGTTC
CATGAAAGTACATTGGGGCACGTGGCTGATTTATGAAGAACCTGGATTTCAGGGTGTTCCTTTCATCCTGGAACCTGGTGAATACCCTGA
CTTGTCCTTCTGGGATACAGAAGAAGCGTACATTGGATCCATGCGGCCTCTGAAAATGGGTGGCCGTAAAGTTGAATTCCCTACAGATCC
AAAGGTAGTTGTTTATGAAAAGCCTTTCTTTGAAGGAAAATGTGTGGAACTAGAAACAGGAATGTGTAGTTTTGTCATGGAGGGAGGTGA
AACAGAAGAGGCGACTGGAGACGATCATTTGCCGTTTACGTCAGTGGGGTCTATGAAAGTTCTAAGAGGCATTTGGGTTGCATATGAGAA
ACCTGGATTTACCGGTCATCAGTATTTGCTAGAAGAAGGAGAATACAGGGACTGGAAAGCCTGGGGAGGTTACAATGGAGAGCTTCAGTC
TTTACGACCTATATTAGGTGATTTTTCAAATGCTCACATGATAATGTACAGTGAAAAAAACTTTGGATCCAAAGGTTCCAGTATTGATGT
ATTGGGAATTGTTGCTAATTTAAAGGAGACTGGATATGGAGTGAAGACACAGTCTATTAATGTACTGAGTGGAGTATGAAGAACTAGCAC
TGGATGGCAGTTTTGATCCAGACCTAAAAAACTATCACAAACTCCATTGGGAAACAGAATTCAAACCTGTGGCACAGCAGCTTCTAAACC
GAATTCAGAGACATCACACCTTCCTGGAACCCCTGCCCATTCCCTCTTTCTAACATGATGCAGATTAACAGTAGAAACGAGAACTCACGT
CTCCCTCATTCTTAAGAACTGGTAACAAACGTGAACATTTTTTTCAGCATTAACAAATGTGGAAAGTTTTTCAAGAACTGGTTTTAGTGA
GTAGCTGAAGTATTTTTTAAAATTAAGCATTTCTTCTTGTTAGGTATTATGGAAAAATGAATATACACATTATATTTCCTGTTGAGAGAA
ATGTAAGATGAAAATATGTGCATTTTCAAGTAAATGACTTTTTCTTCTATTCTCTATTAAACAATTTAGTTCTAGTCTTAAAATCTTGAT
TTAACAATTTTGGAATTGAAGTGTTCATAAGTTAAATGAACTGTGCAATGAAGGCTGTTAGATTATATAGAAAGAAGGGTAGGCAACATG

>3194_3194_2_AIM1-ARMC2_AIM1_chr6_106992808_ENST00000369066_ARMC2_chr6_109294560_ENST00000392644_length(amino acids)=1517AA_BP=
MHSSPGNSSRQENAETPARSPGEDASPGAGHEQEAFLGVRGAPGSPTQERPAGGLGEAPNGAPSVCAEEGSLGPRNARSQPPKGASDLPG
EPPAEGAAHTASSAQADCTARPKGHAHPAKVLTLDIYLSKTEGAQVDEPVVITPRAEDCGDWDDMEKRSSGRRSGRRRGSQKSTDSPGAD
AELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRAALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEA
VPAPPASGPRAPAKESPPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHKRGPLPNHFNGRAEGGRSRELGRAAGAP
GASDADGLKPRNHFGVGRSTVTTKVTLPAKPKHVELNLKTPKNLDSLGNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNT
PASSKTFVGRAKLNLAKKAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEILPATRGMNGDSSENQALGPQPNQDDKADVQTDAG
CLSEPVASALIPVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIPTTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDV
PKDTCVQSPISSFPCTDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVRSFVLPVESTQDVSSQV
IPESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTAELAAKSGPQVIPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSG
NHLATPQRPDQTVTNGQDSPASLLNISAGSDDSVFDSSSDMEKFTEIIKQMDSAVCMPMKRKKARMPNSPAPHFAMPPIHEDHLEKVFDP
KVFTFGLGKKKESQPEMSPALHLMQNLDTKSKLRPKRASAEQSVLFKSLHTNTNGNSEPLVMPEINDKENRDVTNGGIKRSRLEKSALFS
SLLSSLPQDKIFSPSVTSVNTMTTAFSTSQNGSLSQSSVSQPTTEGAPPCGLNKEQSNLLPDNSLKVFNFNSSSTSHSSLKSPSHMEKYP
QKEKTKEDLDSRSNLHLPETKFSELSKLKNDDMEKANHIESVIKSNLPNCANSDTDFMGLFKSSRYDPSISFSGMSLSDTMTLRGSVQNK
LNPRPGKVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRGCWILYEQPNFEGHSIPLEEGELELSGLWGIEDILERHEEAESDK
PVVIGSIRHVVQDYRVSHIDLFTEPEGLGILSSYFDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEE
AYIGSMRPLKMGGRKVEFPTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEKPGFTGHQY

--------------------------------------------------------------
>3194_3194_3_AIM1-ARMC2_AIM1_chr6_106992808_ENST00000535438_ARMC2_chr6_109294560_ENST00000368972_length(transcript)=1035nt_BP=609nt
TGGTAGAGACGGCAACCCCGGGCCTGTGCCCAGCTGAAGGATGAACTGAGGGCAGGATCGTTAAATGCAGAAGCCGAAGACAGTGGCCTG
GGAGAATCTGGGTCCAGAGATGTCAGCTCTTGGAACTGCTTTTTCAAGAGAAGGTGGCCGTAAAGTTGAATTCCCTACAGATCCAAAGGT
AGTTGTTTATGAAAAGCCTTTCTTTGAAGGAAAATGTGTGGAACTAGAAACAGGAATGTGTAGTTTTGTCATGGAGGGAGGTGAAACAGA
AGAGGCGACTGGAGACGATCATTTGCCGTTTACGTCAGTGGGGTCTATGAAAGTTCTAAGAGGCATTTGGGTTGCATATGAGAAACCTGG
ATTTACCGGTCATCAGTATTTGCTAGAAGAAGGAGAATACAGGGACTGGAAAGCCTGGGGAGGTTACAATGGAGAGCTTCAGTCTTTACG
ACCTATATTAGGTGATTTTTCAAATGCTCACATGATAATGTACAGTGAAAAAAACTTTGGATCCAAAGGTTCCAGTATTGATGTATTGGG
AATTGTTGCTAATTTAAAGGAGACTGGATATGGAGTGAAGACACAGTCTATTAATGTACTGAGTGGAGTATGAAGAACTAGCACTGGATG
GCAGTTTTGATCCAGACCTAAAAAACTATCACAAACTCCATTGGGAAACAGAATTCAAACCTGTGGCACAGCAGCTTCTAAACCGAATTC
AGAGACATCACACCTTCCTGGAACCCCTGCCCATTCCCTCTTTCTAACATGATGCAGATTAACAGTAGAAACGAGAACTCACGTCTCCCT
CATTCTTAAGAACTGGTAACAAACGTGAACATTTTTTTCAGCATTAACAAATGTGGAAAGTTTTTCAAGAACTGGTTTTAGTGAGTAGCT
GAAGTATTTTTTAAAATTAAGCATTTCTTCTTGTTAGGTATTATGGAAAAATGAATATACACATTATATTTCCTGTTGAGAGAAATGTAA

>3194_3194_3_AIM1-ARMC2_AIM1_chr6_106992808_ENST00000535438_ARMC2_chr6_109294560_ENST00000368972_length(amino acids)=182AA_BP=
MQKPKTVAWENLGPEMSALGTAFSREGGRKVEFPTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRG
IWVAYEKPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPILGDFSNAHMIMYSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLS

--------------------------------------------------------------
>3194_3194_4_AIM1-ARMC2_AIM1_chr6_106992808_ENST00000535438_ARMC2_chr6_109294560_ENST00000392644_length(transcript)=1236nt_BP=609nt
TGGTAGAGACGGCAACCCCGGGCCTGTGCCCAGCTGAAGGATGAACTGAGGGCAGGATCGTTAAATGCAGAAGCCGAAGACAGTGGCCTG
GGAGAATCTGGGTCCAGAGATGTCAGCTCTTGGAACTGCTTTTTCAAGAGAAGGTGGCCGTAAAGTTGAATTCCCTACAGATCCAAAGGT
AGTTGTTTATGAAAAGCCTTTCTTTGAAGGAAAATGTGTGGAACTAGAAACAGGAATGTGTAGTTTTGTCATGGAGGGAGGTGAAACAGA
AGAGGCGACTGGAGACGATCATTTGCCGTTTACGTCAGTGGGGTCTATGAAAGTTCTAAGAGGCATTTGGGTTGCATATGAGAAACCTGG
ATTTACCGGTCATCAGTATTTGCTAGAAGAAGGAGAATACAGGGACTGGAAAGCCTGGGGAGGTTACAATGGAGAGCTTCAGTCTTTACG
ACCTATATTAGGTGATTTTTCAAATGCTCACATGATAATGTACAGTGAAAAAAACTTTGGATCCAAAGGTTCCAGTATTGATGTATTGGG
AATTGTTGCTAATTTAAAGGAGACTGGATATGGAGTGAAGACACAGTCTATTAATGTACTGAGTGGAGTATGAAGAACTAGCACTGGATG
GCAGTTTTGATCCAGACCTAAAAAACTATCACAAACTCCATTGGGAAACAGAATTCAAACCTGTGGCACAGCAGCTTCTAAACCGAATTC
AGAGACATCACACCTTCCTGGAACCCCTGCCCATTCCCTCTTTCTAACATGATGCAGATTAACAGTAGAAACGAGAACTCACGTCTCCCT
CATTCTTAAGAACTGGTAACAAACGTGAACATTTTTTTCAGCATTAACAAATGTGGAAAGTTTTTCAAGAACTGGTTTTAGTGAGTAGCT
GAAGTATTTTTTAAAATTAAGCATTTCTTCTTGTTAGGTATTATGGAAAAATGAATATACACATTATATTTCCTGTTGAGAGAAATGTAA
GATGAAAATATGTGCATTTTCAAGTAAATGACTTTTTCTTCTATTCTCTATTAAACAATTTAGTTCTAGTCTTAAAATCTTGATTTAACA
ATTTTGGAATTGAAGTGTTCATAAGTTAAATGAACTGTGCAATGAAGGCTGTTAGATTATATAGAAAGAAGGGTAGGCAACATGAGTGGA

>3194_3194_4_AIM1-ARMC2_AIM1_chr6_106992808_ENST00000535438_ARMC2_chr6_109294560_ENST00000392644_length(amino acids)=182AA_BP=
MQKPKTVAWENLGPEMSALGTAFSREGGRKVEFPTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRG
IWVAYEKPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPILGDFSNAHMIMYSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AIM1-ARMC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AIM1-ARMC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AIM1-ARMC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource