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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C6orf203-PDSS2 (FusionGDB2 ID:HG51250TG57107)

Fusion Gene Summary for C6orf203-PDSS2

check button Fusion gene summary
Fusion gene informationFusion gene name: C6orf203-PDSS2
Fusion gene ID: hg51250tg57107
HgeneTgene
Gene symbol

C6orf203

PDSS2

Gene ID

51250

57107

Gene namemitochondrial transcription rescue factor 1decaprenyl diphosphate synthase subunit 2
SynonymsC6orf203|HSPC230|PRED31C6orf210|COQ10D3|COQ1B|DLP1|bA59I9.3|hDLP1
Cytomap('C6orf203')('PDSS2')

6q21

6q21

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial transcription rescue factor 1uncharacterized protein C6orf203decaprenyl-diphosphate synthase subunit 2all-trans-decaprenyl-diphosphate synthase subunit 2decaprenyl pyrophosphate synthase subunit 2decaprenyl pyrophosphate synthetase subunit 2prenyl (decaprenyl) diphosphate synthase, subunit 2subunit 2 of decapr
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000489790, ENST00000311381, 
ENST00000405204, ENST00000443043, 
Fusion gene scores* DoF score2 X 2 X 2=89 X 7 X 6=378
# samples 210
** MAII scorelog2(2/8*10)=1.32192809488736log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C6orf203 [Title/Abstract] AND PDSS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC6orf203(107361434)-PDSS2(107475981), # samples:3
Anticipated loss of major functional domain due to fusion event.C6orf203-PDSS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
C6orf203-PDSS2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
C6orf203-PDSS2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDSS2

GO:0006744

ubiquinone biosynthetic process

16262699

TgenePDSS2

GO:0008299

isoprenoid biosynthetic process

16262699


check buttonFusion gene breakpoints across C6orf203 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PDSS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A43P-01AC6orf203chr6

107349475

+PDSS2chr6

107475981

-
ChimerDB4BLCATCGA-FD-A43P-01AC6orf203chr6

107361434

+PDSS2chr6

107475981

-
ChimerDB4BLCATCGA-FD-A43PC6orf203chr6

107361434

+PDSS2chr6

107475981

-


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Fusion Gene ORF analysis for C6orf203-PDSS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000489790ENST00000369037C6orf203chr6

107361434

+PDSS2chr6

107475981

-
3UTR-3CDSENST00000489790ENST00000453874C6orf203chr6

107361434

+PDSS2chr6

107475981

-
3UTR-intronENST00000489790ENST00000369031C6orf203chr6

107361434

+PDSS2chr6

107475981

-
5CDS-intronENST00000311381ENST00000369031C6orf203chr6

107361434

+PDSS2chr6

107475981

-
5CDS-intronENST00000405204ENST00000369031C6orf203chr6

107361434

+PDSS2chr6

107475981

-
5CDS-intronENST00000443043ENST00000369031C6orf203chr6

107361434

+PDSS2chr6

107475981

-
5UTR-3CDSENST00000311381ENST00000369037C6orf203chr6

107349475

+PDSS2chr6

107475981

-
5UTR-3CDSENST00000311381ENST00000453874C6orf203chr6

107349475

+PDSS2chr6

107475981

-
5UTR-3CDSENST00000405204ENST00000369037C6orf203chr6

107349475

+PDSS2chr6

107475981

-
5UTR-3CDSENST00000405204ENST00000453874C6orf203chr6

107349475

+PDSS2chr6

107475981

-
5UTR-3CDSENST00000443043ENST00000369037C6orf203chr6

107349475

+PDSS2chr6

107475981

-
5UTR-3CDSENST00000443043ENST00000453874C6orf203chr6

107349475

+PDSS2chr6

107475981

-
5UTR-intronENST00000311381ENST00000369031C6orf203chr6

107349475

+PDSS2chr6

107475981

-
5UTR-intronENST00000405204ENST00000369031C6orf203chr6

107349475

+PDSS2chr6

107475981

-
5UTR-intronENST00000443043ENST00000369031C6orf203chr6

107349475

+PDSS2chr6

107475981

-
Frame-shiftENST00000311381ENST00000453874C6orf203chr6

107361434

+PDSS2chr6

107475981

-
Frame-shiftENST00000405204ENST00000453874C6orf203chr6

107361434

+PDSS2chr6

107475981

-
Frame-shiftENST00000443043ENST00000453874C6orf203chr6

107361434

+PDSS2chr6

107475981

-
In-frameENST00000311381ENST00000369037C6orf203chr6

107361434

+PDSS2chr6

107475981

-
In-frameENST00000405204ENST00000369037C6orf203chr6

107361434

+PDSS2chr6

107475981

-
In-frameENST00000443043ENST00000369037C6orf203chr6

107361434

+PDSS2chr6

107475981

-
intron-3CDSENST00000489790ENST00000369037C6orf203chr6

107349475

+PDSS2chr6

107475981

-
intron-3CDSENST00000489790ENST00000453874C6orf203chr6

107349475

+PDSS2chr6

107475981

-
intron-intronENST00000489790ENST00000369031C6orf203chr6

107349475

+PDSS2chr6

107475981

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000405204C6orf203chr6107361434+ENST00000369037PDSS2chr6107475981-329810775291110193
ENST00000443043C6orf203chr6107361434+ENST00000369037PDSS2chr6107475981-338111606751193172
ENST00000311381C6orf203chr6107361434+ENST00000369037PDSS2chr6107475981-276254111574187

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000405204ENST00000369037C6orf203chr6107361434+PDSS2chr6107475981-0.0024845340.99751544
ENST00000443043ENST00000369037C6orf203chr6107361434+PDSS2chr6107475981-0.0030446840.9969553
ENST00000311381ENST00000369037C6orf203chr6107361434+PDSS2chr6107475981-0.0039837020.9960163

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Fusion Genomic Features for C6orf203-PDSS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for C6orf203-PDSS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:107361434/chr6:107475981)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for C6orf203-PDSS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11946_11946_1_C6orf203-PDSS2_C6orf203_chr6_107361434_ENST00000311381_PDSS2_chr6_107475981_ENST00000369037_length(transcript)=2762nt_BP=541nt
AGCCTGGAGGCCTGCAGTCCGCGCGGCCGCGGGGAGGGACGAGAGGGCCTGACGTACAGATTATAAGCGCCATGGCTATGGCTAGTGTTA
AATTGCTTGCCGGTGTTTTAAGAAAGCCAGATGCCTGGATTGGACTCTGGGGTGTTCTCCGAGGGACACCTTCATCATACAAACTCTGTA
CTTCCTGGAATCGATACTTGTATTTTTCTAGTACCAAGTTACGTGCACCAAATTATAAAACACTTTTTTATAATATTTTCTCACTGAGAC
TCCCAGGGCTTTTACTATCTCCAGAATGTATTTTTCCTTTTTCCGTAAGACTCAAAAGTAATATAAGGTCTACAAAATCTACTAAAAAGT
CTCTGCAAAAAGTAGATGAAGAGGACTCTGATGAAGAAAGCCATCATGATGAGATGAGTGAGCAGGAAGAGGAGCTTGAGGATGATCCTA
CTGTAGTCAAAAACTATAAAGACCTGGAAAAAGCAGTTCAGTCTTTTCGGTATGATGTTGTCCTGAAGACGGGGCTAGATATTGGGAGAA
ATTGCGAGAAAGAATCAAAGCTGGCAAAGGTGTGACTTCAGCTATTGACCTGTGTCGTTACCATGGAAACAAGGCACTGGAGGCCCTGGA
GAGCTTTCCTCCCTCGGAGGCCAGATCTGCTTTAGAAAACATTGTGTTTGCTGTGACCAGATTTTCATGACATCAAATTAAAAAGACACT
ATTGTTAGTTAGCTGAAAATCCTAGGGAATGAGGTTGATTGGGAGCGCTTTCACGATGCGTTAATGACTTTTAAAACATATGCATTTTTC
CTTCCTTTTATCACATTGCTAAATGAGTTCTGCTTTCTTTTTGGAACTGCTACAAACAAAATTAGAAGAAAAAAAGGTCAAGCAGTTTTC
ACTTGTCACGCCAGAAGCACACTTGAGGCTGCAGTCGCAGAAATAATTAATGAGATTCGCTCCTGTGACCTCAGCAAATGGACAGGAAAT
AAGTCCTTATTGATTGGACCGAGCCAGGGATGGCGCCAGGGCGGTGGCCTGTGGTTTTTCCTGCTAGAGAGGACAAAGCAAGTTGGAAGC
TGCAGGTGTCAAGAGAAATGCTCTCAATACCAACCAGGGAGGATTGTCTAATCAAAAACTAGTGACCAATTTGTCATAATGGAGAGTAGT
TCAATGGATTGAGAAAAATATGTTTTATTTGTTGGCTTGTAATTATGTCTCTGGATTATTATTATTTTTTTTTTAGATGTAGTTTTGCTC
TTGTTGCCCAGGCTGGAGTGCAATGGTGCAGTTTTGACTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCC
CGAGTAGCTGGAATTACAGGCACCTGCCACCACGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCACTATGTTGGTCAGGCTA
GTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTAGAGGCTTGAGCCACTGCACCTGGCCTCATG
TCTCTGGATTTATAATGCAGTATGAATATACTTTGTGCTTTATGGTTTTTATAATGTCTTTTTGGAGAAATTGCCGAAAAGTTGCCAAAT
ACTTGAAGTAGGAGATTAAAATGTTATCAAATGTTAAATTGGTTATATTAGGAATAGTCTGTTTTTCTTTCCTGAAGATCAGTTTTTTTA
TTCAAACACATTTCAAAGAACCAAATTTTTTTTTTCTTTAAGGAAAAAGGAGCTTTTTTTCAAGTGAAATGTATTCATTTGTAATACTTT
GGTTTAAGGCATACTTTAATTTTTACGAGTTTCAGAAACAGAATTTTTGTACTAGGGAATTCATTGGTGAGAGTGTTCTTTTAACCTCAG
AATGTCAAATTTTGGTCTTGAACCACAGACATCCAATTACAGAAAGAATATAAGCAATCTCACAGGCCTGCAATCGGACACTGTCTCTGT
GTGGTTCATAGGAGATGATTTTTGAGGTTTGCACTCATGCAATTTGAGAACACCGTTGACAAGAAGGCTGAGTTTACATAAATGATCTAG
ATTGAAACTCAGCTACCTTTCTTCCTCATGTGGTGTAATTACAGCCCTATCTGGAGACAGCGAATACAGCAAACAGATTTTATTACCTAG
TTCGCTCAAACACTACATGAAGTTATTTTAGTTAAAGCCCTCCCCCAAAAGTTATAAAACCATTTTATCAGGGCCCAACATGTGGCATGC
AATGAAGAGAAAATGTAAAGCTACAGAGGTTAATGTATTGTATTATAAAATATTTTAAGTGTACTCAAAATATCATAATTGTACAGTTTA
TGCCACCATAATTTGAGGCCTATAGATTTAGCTTAAGAGAACACTGTTCTGTTTGAAATGCTTTCTGTCACTGAAATTGGCTTAATTAGT
AACCATGGATAAGATGCTTTAGATCAGACTAGGTTTTAATCATTAACTTCCACAAAGAAGTCATACTTTGCGTTAGGTGTGCTGGTTGGA
TGTGCAGGAACTTCAGCAAGCAGTAGGTTTTACTAAGCAGATGGTCGGGCACTGCAGGGCACCAGGCAGGATCCTAGGGCGCCTCTTATT
CTGCGTTAGCATCTGGTTTGCTGTATGACCTTGCACAAGTCACTTCCTTCTGAGCCTCAATTTTCTCATCTGTACAATGAGATTCAAAAG

>11946_11946_1_C6orf203-PDSS2_C6orf203_chr6_107361434_ENST00000311381_PDSS2_chr6_107475981_ENST00000369037_length(amino acids)=187AA_BP=
MQSARPRGGTRGPDVQIISAMAMASVKLLAGVLRKPDAWIGLWGVLRGTPSSYKLCTSWNRYLYFSSTKLRAPNYKTLFYNIFSLRLPGL
LLSPECIFPFSVRLKSNIRSTKSTKKSLQKVDEEDSDEESHHDEMSEQEEELEDDPTVVKNYKDLEKAVQSFRYDVVLKTGLDIGRNCEK

--------------------------------------------------------------
>11946_11946_2_C6orf203-PDSS2_C6orf203_chr6_107361434_ENST00000405204_PDSS2_chr6_107475981_ENST00000369037_length(transcript)=3298nt_BP=1077nt
AGATAGGGGTAGCCTGGAGGCCTGCAGTCCGCGCGGCCGCGGGGAGGGACGAGAGGGCCTGACGTACAGGTGAGTGCGCCTCTGCTGGCG
CGCCGCGCCGGGCCCCCTGCCCGCGCCCCCTGTCACTTCGCCTCTCCGCCCCGCCCACGCTCCCGCCGGGTCTCCCCGTGAGTGTCCCGT
GTCCTGCCAGCCTCGGGACGCCCCGCGAGCTCAGGGCTGCGCAGGGACTGTGGTAATTGAGCGCGGCGAAGCCTTCCGTTCCTGCCTCCT
GTCGCTCCTGCTGGCTCCGAATGCAGACTGCGAACCCGGGGACGCAGTTGTCCATTTCCTTTGACCTTGGGGACCCAGGAAGGTGCACTG
CCCGCGGGGGTGGGGAGGGAGCGAGAGGAATCCGACCCTGTCTCAGCCCACAGCCTCCGAGGTCTCCAAGTAAAGGGAAGGATCTTTAGC
TGCATTAGACTTCAAAGCGTTTAGACCAGTTTCTCCATCTTACGGAGCGGTGAACGGGCTCAGGAATGTGGAGCGTTTCCTGGCGTCAAG
CAGGTCAAAGTCAGCGCTGCTTTTTTTACAGACACTGCTTTTCTTACAGTCTTCGATTATAAGCGCCATGGCTATGGCTAGTGTTAAATT
GCTTGCCGGTGTTTTAAGAAAGCCAGATGCCTGGATTGGACTCTGGGGTGTTCTCCGAGGGACACCTTCATCATACAAACTCTGTACTTC
CTGGAATCGATACTTGTATTTTTCTAGTACCAAGTTACGTGCACCAAATTATAAAACACTTTTTTATAATATTTTCTCACTGAGACTCCC
AGGGCTTTTACTATCTCCAGAATGTATTTTTCCTTTTTCCGTAAGACTCAAAAGTAATATAAGGTCTACAAAATCTACTAAAAAGTCTCT
GCAAAAAGTAGATGAAGAGGACTCTGATGAAGAAAGCCATCATGATGAGATGAGTGAGCAGGAAGAGGAGCTTGAGGATGATCCTACTGT
AGTCAAAAACTATAAAGACCTGGAAAAAGCAGTTCAGTCTTTTCGGTATGATGTTGTCCTGAAGACGGGGCTAGATATTGGGAGAAATTG
CGAGAAAGAATCAAAGCTGGCAAAGGTGTGACTTCAGCTATTGACCTGTGTCGTTACCATGGAAACAAGGCACTGGAGGCCCTGGAGAGC
TTTCCTCCCTCGGAGGCCAGATCTGCTTTAGAAAACATTGTGTTTGCTGTGACCAGATTTTCATGACATCAAATTAAAAAGACACTATTG
TTAGTTAGCTGAAAATCCTAGGGAATGAGGTTGATTGGGAGCGCTTTCACGATGCGTTAATGACTTTTAAAACATATGCATTTTTCCTTC
CTTTTATCACATTGCTAAATGAGTTCTGCTTTCTTTTTGGAACTGCTACAAACAAAATTAGAAGAAAAAAAGGTCAAGCAGTTTTCACTT
GTCACGCCAGAAGCACACTTGAGGCTGCAGTCGCAGAAATAATTAATGAGATTCGCTCCTGTGACCTCAGCAAATGGACAGGAAATAAGT
CCTTATTGATTGGACCGAGCCAGGGATGGCGCCAGGGCGGTGGCCTGTGGTTTTTCCTGCTAGAGAGGACAAAGCAAGTTGGAAGCTGCA
GGTGTCAAGAGAAATGCTCTCAATACCAACCAGGGAGGATTGTCTAATCAAAAACTAGTGACCAATTTGTCATAATGGAGAGTAGTTCAA
TGGATTGAGAAAAATATGTTTTATTTGTTGGCTTGTAATTATGTCTCTGGATTATTATTATTTTTTTTTTAGATGTAGTTTTGCTCTTGT
TGCCCAGGCTGGAGTGCAATGGTGCAGTTTTGACTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAG
TAGCTGGAATTACAGGCACCTGCCACCACGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCACTATGTTGGTCAGGCTAGTCT
CGAACTCCTGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTAGAGGCTTGAGCCACTGCACCTGGCCTCATGTCTC
TGGATTTATAATGCAGTATGAATATACTTTGTGCTTTATGGTTTTTATAATGTCTTTTTGGAGAAATTGCCGAAAAGTTGCCAAATACTT
GAAGTAGGAGATTAAAATGTTATCAAATGTTAAATTGGTTATATTAGGAATAGTCTGTTTTTCTTTCCTGAAGATCAGTTTTTTTATTCA
AACACATTTCAAAGAACCAAATTTTTTTTTTCTTTAAGGAAAAAGGAGCTTTTTTTCAAGTGAAATGTATTCATTTGTAATACTTTGGTT
TAAGGCATACTTTAATTTTTACGAGTTTCAGAAACAGAATTTTTGTACTAGGGAATTCATTGGTGAGAGTGTTCTTTTAACCTCAGAATG
TCAAATTTTGGTCTTGAACCACAGACATCCAATTACAGAAAGAATATAAGCAATCTCACAGGCCTGCAATCGGACACTGTCTCTGTGTGG
TTCATAGGAGATGATTTTTGAGGTTTGCACTCATGCAATTTGAGAACACCGTTGACAAGAAGGCTGAGTTTACATAAATGATCTAGATTG
AAACTCAGCTACCTTTCTTCCTCATGTGGTGTAATTACAGCCCTATCTGGAGACAGCGAATACAGCAAACAGATTTTATTACCTAGTTCG
CTCAAACACTACATGAAGTTATTTTAGTTAAAGCCCTCCCCCAAAAGTTATAAAACCATTTTATCAGGGCCCAACATGTGGCATGCAATG
AAGAGAAAATGTAAAGCTACAGAGGTTAATGTATTGTATTATAAAATATTTTAAGTGTACTCAAAATATCATAATTGTACAGTTTATGCC
ACCATAATTTGAGGCCTATAGATTTAGCTTAAGAGAACACTGTTCTGTTTGAAATGCTTTCTGTCACTGAAATTGGCTTAATTAGTAACC
ATGGATAAGATGCTTTAGATCAGACTAGGTTTTAATCATTAACTTCCACAAAGAAGTCATACTTTGCGTTAGGTGTGCTGGTTGGATGTG
CAGGAACTTCAGCAAGCAGTAGGTTTTACTAAGCAGATGGTCGGGCACTGCAGGGCACCAGGCAGGATCCTAGGGCGCCTCTTATTCTGC
GTTAGCATCTGGTTTGCTGTATGACCTTGCACAAGTCACTTCCTTCTGAGCCTCAATTTTCTCATCTGTACAATGAGATTCAAAAGTTGA

>11946_11946_2_C6orf203-PDSS2_C6orf203_chr6_107361434_ENST00000405204_PDSS2_chr6_107475981_ENST00000369037_length(amino acids)=193AA_BP=
MASSRSKSALLFLQTLLFLQSSIISAMAMASVKLLAGVLRKPDAWIGLWGVLRGTPSSYKLCTSWNRYLYFSSTKLRAPNYKTLFYNIFS
LRLPGLLLSPECIFPFSVRLKSNIRSTKSTKKSLQKVDEEDSDEESHHDEMSEQEEELEDDPTVVKNYKDLEKAVQSFRYDVVLKTGLDI

--------------------------------------------------------------
>11946_11946_3_C6orf203-PDSS2_C6orf203_chr6_107361434_ENST00000443043_PDSS2_chr6_107475981_ENST00000369037_length(transcript)=3381nt_BP=1160nt
AGATAGGGGTAGCCTGGAGGCCTGCAGTCCGCGCGGCCGCGGGGAGGGACGAGAGGGCCTGACGTACAGGTGAGTGCGCCTCTGCTGGCG
CGCCGCGCCGGGCCCCCTGCCCGCGCCCCCTGTCACTTCGCCTCTCCGCCCCGCCCACGCTCCCGCCGGGTCTCCCCGTGAGTGTCCCGT
GTCCTGCCAGCCTCGGGACGCCCCGCGAGCTCAGGGCTGCGCAGGGACTGTGGTAATTGAGCGCGGCGAAGCCTTCCGTTCCTGCCTCCT
GTCGCTCCTGCTGGCTCCGAATGCAGACTGCGAACCCGGGGACGCAGTTGTCCATTTCCTTTGACCTTGGGGACCCAGGAAGGTGCACTG
CCCGCGGGGGTGGGGAGGGAGCGAGAGGAATCCGACCCTGTCTCAGCCCACAGCCTCCGAGGTCTCCAAGTAAAGGGAAGGATCTTTAGC
TGCATTAGACTTCAAAGCGTTTAGACCAGTTTCTCCATCTTACGGAGCGGTGAACGGGCTCAGGAATGTGGAGCGTTTCCTGGCGTCAAG
CAGGTCAAAGTCAGCGCTGCTTTTTTTACAGACACTGCTTTTCTTACAGTCTTCGACTATAAACTCTACAAGAATAGGAATCTTCGTATT
TTTTTCCTCTGCTGAATTCCTAGTGCCCAGATTAGTGCTTGGCACATGATTATAAGCGCCATGGCTATGGCTAGTGTTAAATTGCTTGCC
GGTGTTTTAAGAAAGCCAGATGCCTGGATTGGACTCTGGGGTGTTCTCCGAGGGACACCTTCATCATACAAACTCTGTACTTCCTGGAAT
CGATACTTGTATTTTTCTAGTACCAAGTTACGTGCACCAAATTATAAAACACTTTTTTATAATATTTTCTCACTGAGACTCCCAGGGCTT
TTACTATCTCCAGAATGTATTTTTCCTTTTTCCGTAAGACTCAAAAGTAATATAAGGTCTACAAAATCTACTAAAAAGTCTCTGCAAAAA
GTAGATGAAGAGGACTCTGATGAAGAAAGCCATCATGATGAGATGAGTGAGCAGGAAGAGGAGCTTGAGGATGATCCTACTGTAGTCAAA
AACTATAAAGACCTGGAAAAAGCAGTTCAGTCTTTTCGGTATGATGTTGTCCTGAAGACGGGGCTAGATATTGGGAGAAATTGCGAGAAA
GAATCAAAGCTGGCAAAGGTGTGACTTCAGCTATTGACCTGTGTCGTTACCATGGAAACAAGGCACTGGAGGCCCTGGAGAGCTTTCCTC
CCTCGGAGGCCAGATCTGCTTTAGAAAACATTGTGTTTGCTGTGACCAGATTTTCATGACATCAAATTAAAAAGACACTATTGTTAGTTA
GCTGAAAATCCTAGGGAATGAGGTTGATTGGGAGCGCTTTCACGATGCGTTAATGACTTTTAAAACATATGCATTTTTCCTTCCTTTTAT
CACATTGCTAAATGAGTTCTGCTTTCTTTTTGGAACTGCTACAAACAAAATTAGAAGAAAAAAAGGTCAAGCAGTTTTCACTTGTCACGC
CAGAAGCACACTTGAGGCTGCAGTCGCAGAAATAATTAATGAGATTCGCTCCTGTGACCTCAGCAAATGGACAGGAAATAAGTCCTTATT
GATTGGACCGAGCCAGGGATGGCGCCAGGGCGGTGGCCTGTGGTTTTTCCTGCTAGAGAGGACAAAGCAAGTTGGAAGCTGCAGGTGTCA
AGAGAAATGCTCTCAATACCAACCAGGGAGGATTGTCTAATCAAAAACTAGTGACCAATTTGTCATAATGGAGAGTAGTTCAATGGATTG
AGAAAAATATGTTTTATTTGTTGGCTTGTAATTATGTCTCTGGATTATTATTATTTTTTTTTTAGATGTAGTTTTGCTCTTGTTGCCCAG
GCTGGAGTGCAATGGTGCAGTTTTGACTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGG
AATTACAGGCACCTGCCACCACGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCACTATGTTGGTCAGGCTAGTCTCGAACTC
CTGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTAGAGGCTTGAGCCACTGCACCTGGCCTCATGTCTCTGGATTT
ATAATGCAGTATGAATATACTTTGTGCTTTATGGTTTTTATAATGTCTTTTTGGAGAAATTGCCGAAAAGTTGCCAAATACTTGAAGTAG
GAGATTAAAATGTTATCAAATGTTAAATTGGTTATATTAGGAATAGTCTGTTTTTCTTTCCTGAAGATCAGTTTTTTTATTCAAACACAT
TTCAAAGAACCAAATTTTTTTTTTCTTTAAGGAAAAAGGAGCTTTTTTTCAAGTGAAATGTATTCATTTGTAATACTTTGGTTTAAGGCA
TACTTTAATTTTTACGAGTTTCAGAAACAGAATTTTTGTACTAGGGAATTCATTGGTGAGAGTGTTCTTTTAACCTCAGAATGTCAAATT
TTGGTCTTGAACCACAGACATCCAATTACAGAAAGAATATAAGCAATCTCACAGGCCTGCAATCGGACACTGTCTCTGTGTGGTTCATAG
GAGATGATTTTTGAGGTTTGCACTCATGCAATTTGAGAACACCGTTGACAAGAAGGCTGAGTTTACATAAATGATCTAGATTGAAACTCA
GCTACCTTTCTTCCTCATGTGGTGTAATTACAGCCCTATCTGGAGACAGCGAATACAGCAAACAGATTTTATTACCTAGTTCGCTCAAAC
ACTACATGAAGTTATTTTAGTTAAAGCCCTCCCCCAAAAGTTATAAAACCATTTTATCAGGGCCCAACATGTGGCATGCAATGAAGAGAA
AATGTAAAGCTACAGAGGTTAATGTATTGTATTATAAAATATTTTAAGTGTACTCAAAATATCATAATTGTACAGTTTATGCCACCATAA
TTTGAGGCCTATAGATTTAGCTTAAGAGAACACTGTTCTGTTTGAAATGCTTTCTGTCACTGAAATTGGCTTAATTAGTAACCATGGATA
AGATGCTTTAGATCAGACTAGGTTTTAATCATTAACTTCCACAAAGAAGTCATACTTTGCGTTAGGTGTGCTGGTTGGATGTGCAGGAAC
TTCAGCAAGCAGTAGGTTTTACTAAGCAGATGGTCGGGCACTGCAGGGCACCAGGCAGGATCCTAGGGCGCCTCTTATTCTGCGTTAGCA
TCTGGTTTGCTGTATGACCTTGCACAAGTCACTTCCTTCTGAGCCTCAATTTTCTCATCTGTACAATGAGATTCAAAAGTTGACCTGAAA

>11946_11946_3_C6orf203-PDSS2_C6orf203_chr6_107361434_ENST00000443043_PDSS2_chr6_107475981_ENST00000369037_length(amino acids)=172AA_BP=
MIISAMAMASVKLLAGVLRKPDAWIGLWGVLRGTPSSYKLCTSWNRYLYFSSTKLRAPNYKTLFYNIFSLRLPGLLLSPECIFPFSVRLK

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Fusion Gene PPI Analysis for C6orf203-PDSS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C6orf203-PDSS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C6orf203-PDSS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC3553358COENZYME Q10 DEFICIENCY, PRIMARY, 33CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0023264Leigh Disease1GENOMICS_ENGLAND