Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ECSIT-RGL3 (FusionGDB2 ID:HG51295TG57139)

Fusion Gene Summary for ECSIT-RGL3

check button Fusion gene summary
Fusion gene informationFusion gene name: ECSIT-RGL3
Fusion gene ID: hg51295tg57139
HgeneTgene
Gene symbol

ECSIT

RGL3

Gene ID

51295

57139

Gene nameECSIT signaling integratorral guanine nucleotide dissociation stimulator like 3
SynonymsSITPEC-
Cytomap('ECSIT')('RGL3')

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionevolutionarily conserved signaling intermediate in Toll pathway, mitochondrialECSIT homologECSIT signalling integratorlikely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conservedral guanine nucleotide dissociation stimulator-like 3RalGEF-like protein 3, mouse homologralGDS-like 3
Modification date2020031320200313
UniProtAcc

Q9BQ95

.
Ensembl transtripts involved in fusion geneENST00000252440, ENST00000270517, 
ENST00000591104, ENST00000592312, 
ENST00000417981, ENST00000588998, 
ENST00000591352, 
ENST00000252440, 
ENST00000417981, ENST00000588998, 
ENST00000591104, ENST00000592312, 
ENST00000591352, ENST00000270517, 
Fusion gene scores* DoF score4 X 3 X 5=603 X 3 X 4=36
# samples 65
** MAII scorelog2(6/60*10)=0log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ECSIT [Title/Abstract] AND RGL3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointECSIT(11623871)-RGL3(11508273), # samples:2
ECSIT(11623871)-RGL3(11517540), # samples:2
ECSIT(11623870)-RGL3(11508273), # samples:2
Anticipated loss of major functional domain due to fusion event.ECSIT-RGL3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ECSIT-RGL3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ECSIT-RGL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ECSIT-RGL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RGL3-ECSIT seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ECSIT-RGL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneECSIT

GO:0051341

regulation of oxidoreductase activity

17344420

HgeneECSIT

GO:0061635

regulation of protein complex stability

17344420


check buttonFusion gene breakpoints across ECSIT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RGL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A8NG-01AECSITchr19

11623871

-RGL3chr19

11508273

-
ChimerDB4ESCATCGA-L5-A8NGECSITchr19

11623870

-RGL3chr19

11508273

-
ChimerDB4ESCATCGA-L5-A8NGECSITchr19

11623871

-RGL3chr19

11508273

-
ChimerDB4PRADTCGA-CH-5744-01AECSITchr19

11623871

-RGL3chr19

11517540

-
ChimerDB4PRADTCGA-CH-5744ECSITchr19

11623871

-RGL3chr19

11517540

-


Top

Fusion Gene ORF analysis for ECSIT-RGL3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000252440ENST00000393423ECSITchr19

11623871

-RGL3chr19

11508273

-
5CDS-intronENST00000252440ENST00000393423ECSITchr19

11623870

-RGL3chr19

11508273

-
5CDS-intronENST00000252440ENST00000393423ECSITchr19

11623871

-RGL3chr19

11517540

-
5CDS-intronENST00000252440ENST00000568628ECSITchr19

11623871

-RGL3chr19

11508273

-
5CDS-intronENST00000252440ENST00000568628ECSITchr19

11623870

-RGL3chr19

11508273

-
5CDS-intronENST00000252440ENST00000568628ECSITchr19

11623871

-RGL3chr19

11517540

-
5CDS-intronENST00000270517ENST00000393423ECSITchr19

11623871

-RGL3chr19

11508273

-
5CDS-intronENST00000270517ENST00000393423ECSITchr19

11623870

-RGL3chr19

11508273

-
5CDS-intronENST00000270517ENST00000393423ECSITchr19

11623871

-RGL3chr19

11517540

-
5CDS-intronENST00000270517ENST00000568628ECSITchr19

11623871

-RGL3chr19

11508273

-
5CDS-intronENST00000270517ENST00000568628ECSITchr19

11623870

-RGL3chr19

11508273

-
5CDS-intronENST00000270517ENST00000568628ECSITchr19

11623871

-RGL3chr19

11517540

-
5CDS-intronENST00000591104ENST00000393423ECSITchr19

11623871

-RGL3chr19

11508273

-
5CDS-intronENST00000591104ENST00000393423ECSITchr19

11623870

-RGL3chr19

11508273

-
5CDS-intronENST00000591104ENST00000393423ECSITchr19

11623871

-RGL3chr19

11517540

-
5CDS-intronENST00000591104ENST00000568628ECSITchr19

11623871

-RGL3chr19

11508273

-
5CDS-intronENST00000591104ENST00000568628ECSITchr19

11623870

-RGL3chr19

11508273

-
5CDS-intronENST00000591104ENST00000568628ECSITchr19

11623871

-RGL3chr19

11517540

-
5CDS-intronENST00000592312ENST00000393423ECSITchr19

11623871

-RGL3chr19

11508273

-
5CDS-intronENST00000592312ENST00000393423ECSITchr19

11623870

-RGL3chr19

11508273

-
5CDS-intronENST00000592312ENST00000393423ECSITchr19

11623871

-RGL3chr19

11517540

-
5CDS-intronENST00000592312ENST00000568628ECSITchr19

11623871

-RGL3chr19

11508273

-
5CDS-intronENST00000592312ENST00000568628ECSITchr19

11623870

-RGL3chr19

11508273

-
5CDS-intronENST00000592312ENST00000568628ECSITchr19

11623871

-RGL3chr19

11517540

-
Frame-shiftENST00000252440ENST00000380456ECSITchr19

11623871

-RGL3chr19

11517540

-
Frame-shiftENST00000270517ENST00000380456ECSITchr19

11623871

-RGL3chr19

11508273

-
Frame-shiftENST00000270517ENST00000380456ECSITchr19

11623870

-RGL3chr19

11508273

-
Frame-shiftENST00000270517ENST00000380456ECSITchr19

11623871

-RGL3chr19

11517540

-
Frame-shiftENST00000591104ENST00000380456ECSITchr19

11623871

-RGL3chr19

11508273

-
Frame-shiftENST00000591104ENST00000380456ECSITchr19

11623870

-RGL3chr19

11508273

-
Frame-shiftENST00000591104ENST00000380456ECSITchr19

11623871

-RGL3chr19

11517540

-
Frame-shiftENST00000592312ENST00000380456ECSITchr19

11623871

-RGL3chr19

11508273

-
Frame-shiftENST00000592312ENST00000380456ECSITchr19

11623870

-RGL3chr19

11508273

-
Frame-shiftENST00000592312ENST00000380456ECSITchr19

11623871

-RGL3chr19

11517540

-
In-frameENST00000252440ENST00000380456ECSITchr19

11623871

-RGL3chr19

11508273

-
In-frameENST00000252440ENST00000380456ECSITchr19

11623870

-RGL3chr19

11508273

-
intron-3CDSENST00000417981ENST00000380456ECSITchr19

11623871

-RGL3chr19

11508273

-
intron-3CDSENST00000417981ENST00000380456ECSITchr19

11623870

-RGL3chr19

11508273

-
intron-3CDSENST00000417981ENST00000380456ECSITchr19

11623871

-RGL3chr19

11517540

-
intron-3CDSENST00000588998ENST00000380456ECSITchr19

11623871

-RGL3chr19

11508273

-
intron-3CDSENST00000588998ENST00000380456ECSITchr19

11623870

-RGL3chr19

11508273

-
intron-3CDSENST00000588998ENST00000380456ECSITchr19

11623871

-RGL3chr19

11517540

-
intron-3CDSENST00000591352ENST00000380456ECSITchr19

11623871

-RGL3chr19

11508273

-
intron-3CDSENST00000591352ENST00000380456ECSITchr19

11623870

-RGL3chr19

11508273

-
intron-3CDSENST00000591352ENST00000380456ECSITchr19

11623871

-RGL3chr19

11517540

-
intron-intronENST00000417981ENST00000393423ECSITchr19

11623871

-RGL3chr19

11508273

-
intron-intronENST00000417981ENST00000393423ECSITchr19

11623870

-RGL3chr19

11508273

-
intron-intronENST00000417981ENST00000393423ECSITchr19

11623871

-RGL3chr19

11517540

-
intron-intronENST00000417981ENST00000568628ECSITchr19

11623871

-RGL3chr19

11508273

-
intron-intronENST00000417981ENST00000568628ECSITchr19

11623870

-RGL3chr19

11508273

-
intron-intronENST00000417981ENST00000568628ECSITchr19

11623871

-RGL3chr19

11517540

-
intron-intronENST00000588998ENST00000393423ECSITchr19

11623871

-RGL3chr19

11508273

-
intron-intronENST00000588998ENST00000393423ECSITchr19

11623870

-RGL3chr19

11508273

-
intron-intronENST00000588998ENST00000393423ECSITchr19

11623871

-RGL3chr19

11517540

-
intron-intronENST00000588998ENST00000568628ECSITchr19

11623871

-RGL3chr19

11508273

-
intron-intronENST00000588998ENST00000568628ECSITchr19

11623870

-RGL3chr19

11508273

-
intron-intronENST00000588998ENST00000568628ECSITchr19

11623871

-RGL3chr19

11517540

-
intron-intronENST00000591352ENST00000393423ECSITchr19

11623871

-RGL3chr19

11508273

-
intron-intronENST00000591352ENST00000393423ECSITchr19

11623870

-RGL3chr19

11508273

-
intron-intronENST00000591352ENST00000393423ECSITchr19

11623871

-RGL3chr19

11517540

-
intron-intronENST00000591352ENST00000568628ECSITchr19

11623871

-RGL3chr19

11508273

-
intron-intronENST00000591352ENST00000568628ECSITchr19

11623870

-RGL3chr19

11508273

-
intron-intronENST00000591352ENST00000568628ECSITchr19

11623871

-RGL3chr19

11517540

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000252440ECSITchr1911623871-ENST00000380456RGL3chr1911508273-15698371397120425
ENST00000252440ECSITchr1911623870-ENST00000380456RGL3chr1911508273-15698371397120425

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000252440ENST00000380456ECSITchr1911623871-RGL3chr1911508273-0.064313310.9356867
ENST00000252440ENST00000380456ECSITchr1911623870-RGL3chr1911508273-0.064313310.9356867

Top

Fusion Genomic Features for ECSIT-RGL3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for ECSIT-RGL3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:11623871/chr19:11508273)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ECSIT

Q9BQ95

.
FUNCTION: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). {ECO:0000250}.; FUNCTION: Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRGL3chr19:11623870chr19:11508273ENST000003804561519613_700582711.0DomainRas-associating
TgeneRGL3chr19:11623870chr19:11508273ENST000003934231519613_700588717.0DomainRas-associating
TgeneRGL3chr19:11623871chr19:11508273ENST000003804561519613_700582711.0DomainRas-associating
TgeneRGL3chr19:11623871chr19:11508273ENST000003934231519613_700588717.0DomainRas-associating

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRGL3chr19:11623870chr19:11508273ENST000003804561519231_234582711.0Compositional biasNote=Poly-Glu
TgeneRGL3chr19:11623870chr19:11508273ENST000003804561519537_607582711.0Compositional biasNote=Pro-rich
TgeneRGL3chr19:11623870chr19:11508273ENST000003934231519231_234588717.0Compositional biasNote=Poly-Glu
TgeneRGL3chr19:11623870chr19:11508273ENST000003934231519537_607588717.0Compositional biasNote=Pro-rich
TgeneRGL3chr19:11623871chr19:11508273ENST000003804561519231_234582711.0Compositional biasNote=Poly-Glu
TgeneRGL3chr19:11623871chr19:11508273ENST000003804561519537_607582711.0Compositional biasNote=Pro-rich
TgeneRGL3chr19:11623871chr19:11508273ENST000003934231519231_234588717.0Compositional biasNote=Poly-Glu
TgeneRGL3chr19:11623871chr19:11508273ENST000003934231519537_607588717.0Compositional biasNote=Pro-rich
TgeneRGL3chr19:11623870chr19:11508273ENST000003804561519247_505582711.0DomainRas-GEF
TgeneRGL3chr19:11623870chr19:11508273ENST00000380456151965_200582711.0DomainN-terminal Ras-GEF
TgeneRGL3chr19:11623870chr19:11508273ENST000003934231519247_505588717.0DomainRas-GEF
TgeneRGL3chr19:11623870chr19:11508273ENST00000393423151965_200588717.0DomainN-terminal Ras-GEF
TgeneRGL3chr19:11623871chr19:11508273ENST000003804561519247_505582711.0DomainRas-GEF
TgeneRGL3chr19:11623871chr19:11508273ENST00000380456151965_200582711.0DomainN-terminal Ras-GEF
TgeneRGL3chr19:11623871chr19:11508273ENST000003934231519247_505588717.0DomainRas-GEF
TgeneRGL3chr19:11623871chr19:11508273ENST00000393423151965_200588717.0DomainN-terminal Ras-GEF


Top

Fusion Gene Sequence for ECSIT-RGL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24914_24914_1_ECSIT-RGL3_ECSIT_chr19_11623870_ENST00000252440_RGL3_chr19_11508273_ENST00000380456_length(transcript)=1569nt_BP=837nt
GCTCTCTGGGCCAATATGGCAGCGCCCAGCAACAAGACAGAGCTGGCCTGGAGTCCGCGGCTGGCCGCGTGAGTAGGTGATTGTCTGACA
AGCAGAGGCATGAGCTGGGTCCAGGCCACCCTACTGGCCCGAGGCCTCTGTAGGGCCTGGGGAGGCACCTGCGGGGCCGCCCTCACAGGA
ACCTCCATCTCTCAGGTCCCTCGCCGGCTCCCTCGGGGCCTCCACTGCAGCGCAGCTGCCCATAGCTCTGAACAGTCCCTGGTTCCCAGC
CCACCGGAACCCCGGCAGAGGCCCACCAAGGCTCTGGTGCCCTTTGAGGACCTGTTTGGGCAGGCGCCTGGTGGGGAACGGGACAAGGCG
AGCTTCCTGCAGACGGTGCAGAAATTTGCGGAGCACAGCGTGCGTAAGCGGGGCCACATTGACTTCATCTACCTGGCCCTGCGCAAGATG
CGGGAGTATGGTGTCGAGCGGGACCTGGCTGTGTACAACCAGCTGCTCAACATCTTCCCCAAGGAGGTCTTCCGGCCTCGCAACATCATC
CAGCGCATCTTCGTCCACTACCCTCGGCAGCAGGAGTGTGGGATTGCTGTCCTGGAGCAGATGGAGAACCACGGTGTGATGCCCAACAAG
GAGACGGAGTTCCTGCTGATTCAGATCTTTGGACGCAAAAGCTACCCCATGCTCAAGTTGGTGCGCCTGAAGCTGTGGTTCCCTCGATTC
ATGAACGTCAACCCCTTCCCAGTGCCCCGGGACCTGCCCCAGGACCCTGTGGAGCTGGCCATGTTTGGCCTGCGGCACATGGAGCCTGAC
CTTAGTGCCAGGGTCACCATCTACCAGCTGCCCCTGAGCCTGGACCTGCCCAGCCCCCGGCCCTTCGCTTTGCCTCTGGGCAGCCCTCGA
ATCCCCCTCCCGGCGCAGCAGAGCTCGGAGGCCCGTGTCATCCGCGTCAGCATCGACAATGACCACGGGAACCTGTATCGAAGCATCTTG
CTGACCAGTCAGGACAAAGCCCCCAGCGTGGTCCGGCGAGCCTTGCAGAAGCACAATGTGCCCCAGCCCTGGGCCTGTGACTATCAGCTC
TTTCAAGTCCTTCCTGGGGACCGGGTGCTCCTGATTCCTGACAATGCCAACGTCTTCTATGCCATGAGTCCAGTCGCCCCCAGAGACTTC
ATGCTGCGGCGGAAAGAGGGGACCCGGAACACTCTGTCTGTCTCCCCAAGCTGAGGCAGCCCTGTCCTCTCCACAAGACACAAGTCCCAC
AGGCAAGCTTGCGACTCTTCTCCTGGAAAGCTGCCATCCCCCAGTAGAGGCCACTGTGCTGTGTATCCCAGGACCACCACCCAACTGTAG
CCCATTGGACCCCATCTCTTTTTCTGACTCTGTTGGTACTAGATCCATATTCCAAAGACATCAGCCCATGGGTGGCTGGTGGAGAGCTCA
ATCCCATAAATGTAGAAAGAGGTGGGGCATGGATACGTCAAATCCCTCCCCAGAGAAATCTTATAAATGTTAGAGACGCATCAGAAGTGA

>24914_24914_1_ECSIT-RGL3_ECSIT_chr19_11623870_ENST00000252440_RGL3_chr19_11508273_ENST00000380456_length(amino acids)=425AA_BP=0
MDLVPTESEKEMGSNGLQLGGGPGIHSTVASTGGWQLSRRRVASLPVGLVSCGEDRAASAWGDRQSVPGPLFPPQHEVSGGDWTHGIEDV
GIVRNQEHPVPRKDLKELIVTGPGLGHIVLLQGSPDHAGGFVLTGQQDASIQVPVVIVDADADDTGLRALLRREGDSRAAQRQSEGPGAG
QVQAQGQLVDGDPGTKVRLHVPQAKHGQLHRVLGQVPGHWEGVDVHESREPQLQAHQLEHGVAFASKDLNQQELRLLVGHHTVVLHLLQD
SNPTLLLPRVVDEDALDDVARPEDLLGEDVEQLVVHSQVPLDTILPHLAQGQVDEVNVAPLTHAVLRKFLHRLQEARLVPFPTRRLPKQV

--------------------------------------------------------------
>24914_24914_2_ECSIT-RGL3_ECSIT_chr19_11623871_ENST00000252440_RGL3_chr19_11508273_ENST00000380456_length(transcript)=1569nt_BP=837nt
GCTCTCTGGGCCAATATGGCAGCGCCCAGCAACAAGACAGAGCTGGCCTGGAGTCCGCGGCTGGCCGCGTGAGTAGGTGATTGTCTGACA
AGCAGAGGCATGAGCTGGGTCCAGGCCACCCTACTGGCCCGAGGCCTCTGTAGGGCCTGGGGAGGCACCTGCGGGGCCGCCCTCACAGGA
ACCTCCATCTCTCAGGTCCCTCGCCGGCTCCCTCGGGGCCTCCACTGCAGCGCAGCTGCCCATAGCTCTGAACAGTCCCTGGTTCCCAGC
CCACCGGAACCCCGGCAGAGGCCCACCAAGGCTCTGGTGCCCTTTGAGGACCTGTTTGGGCAGGCGCCTGGTGGGGAACGGGACAAGGCG
AGCTTCCTGCAGACGGTGCAGAAATTTGCGGAGCACAGCGTGCGTAAGCGGGGCCACATTGACTTCATCTACCTGGCCCTGCGCAAGATG
CGGGAGTATGGTGTCGAGCGGGACCTGGCTGTGTACAACCAGCTGCTCAACATCTTCCCCAAGGAGGTCTTCCGGCCTCGCAACATCATC
CAGCGCATCTTCGTCCACTACCCTCGGCAGCAGGAGTGTGGGATTGCTGTCCTGGAGCAGATGGAGAACCACGGTGTGATGCCCAACAAG
GAGACGGAGTTCCTGCTGATTCAGATCTTTGGACGCAAAAGCTACCCCATGCTCAAGTTGGTGCGCCTGAAGCTGTGGTTCCCTCGATTC
ATGAACGTCAACCCCTTCCCAGTGCCCCGGGACCTGCCCCAGGACCCTGTGGAGCTGGCCATGTTTGGCCTGCGGCACATGGAGCCTGAC
CTTAGTGCCAGGGTCACCATCTACCAGCTGCCCCTGAGCCTGGACCTGCCCAGCCCCCGGCCCTTCGCTTTGCCTCTGGGCAGCCCTCGA
ATCCCCCTCCCGGCGCAGCAGAGCTCGGAGGCCCGTGTCATCCGCGTCAGCATCGACAATGACCACGGGAACCTGTATCGAAGCATCTTG
CTGACCAGTCAGGACAAAGCCCCCAGCGTGGTCCGGCGAGCCTTGCAGAAGCACAATGTGCCCCAGCCCTGGGCCTGTGACTATCAGCTC
TTTCAAGTCCTTCCTGGGGACCGGGTGCTCCTGATTCCTGACAATGCCAACGTCTTCTATGCCATGAGTCCAGTCGCCCCCAGAGACTTC
ATGCTGCGGCGGAAAGAGGGGACCCGGAACACTCTGTCTGTCTCCCCAAGCTGAGGCAGCCCTGTCCTCTCCACAAGACACAAGTCCCAC
AGGCAAGCTTGCGACTCTTCTCCTGGAAAGCTGCCATCCCCCAGTAGAGGCCACTGTGCTGTGTATCCCAGGACCACCACCCAACTGTAG
CCCATTGGACCCCATCTCTTTTTCTGACTCTGTTGGTACTAGATCCATATTCCAAAGACATCAGCCCATGGGTGGCTGGTGGAGAGCTCA
ATCCCATAAATGTAGAAAGAGGTGGGGCATGGATACGTCAAATCCCTCCCCAGAGAAATCTTATAAATGTTAGAGACGCATCAGAAGTGA

>24914_24914_2_ECSIT-RGL3_ECSIT_chr19_11623871_ENST00000252440_RGL3_chr19_11508273_ENST00000380456_length(amino acids)=425AA_BP=0
MDLVPTESEKEMGSNGLQLGGGPGIHSTVASTGGWQLSRRRVASLPVGLVSCGEDRAASAWGDRQSVPGPLFPPQHEVSGGDWTHGIEDV
GIVRNQEHPVPRKDLKELIVTGPGLGHIVLLQGSPDHAGGFVLTGQQDASIQVPVVIVDADADDTGLRALLRREGDSRAAQRQSEGPGAG
QVQAQGQLVDGDPGTKVRLHVPQAKHGQLHRVLGQVPGHWEGVDVHESREPQLQAHQLEHGVAFASKDLNQQELRLLVGHHTVVLHLLQD
SNPTLLLPRVVDEDALDDVARPEDLLGEDVEQLVVHSQVPLDTILPHLAQGQVDEVNVAPLTHAVLRKFLHRLQEARLVPFPTRRLPKQV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ECSIT-RGL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRGL3chr19:11623870chr19:11508273ENST000003804561519612_707582.0711.0HRAS%2C MRAS and RIT1
TgeneRGL3chr19:11623870chr19:11508273ENST000003934231519612_707588.0717.0HRAS%2C MRAS and RIT1
TgeneRGL3chr19:11623871chr19:11508273ENST000003804561519612_707582.0711.0HRAS%2C MRAS and RIT1
TgeneRGL3chr19:11623871chr19:11508273ENST000003934231519612_707588.0717.0HRAS%2C MRAS and RIT1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ECSIT-RGL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ECSIT-RGL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneECSITC3495676Anorectal Malformations1GENOMICS_ENGLAND