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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ARL6IP4-LIG1 (FusionGDB2 ID:HG51329TG3978) |
Fusion Gene Summary for ARL6IP4-LIG1 |
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Fusion gene information | Fusion gene name: ARL6IP4-LIG1 | Fusion gene ID: hg51329tg3978 | Hgene | Tgene | Gene symbol | ARL6IP4 | LIG1 | Gene ID | 51329 | 3978 |
Gene name | ADP ribosylation factor like GTPase 6 interacting protein 4 | DNA ligase 1 | |
Synonyms | SFRS20|SR-25|SRp25|SRrp37 | - | |
Cytomap | ('ARL6IP4')('LIG1') 12q24.31 | 19q13.33 | |
Type of gene | protein-coding | protein-coding | |
Description | ADP-ribosylation factor-like protein 6-interacting protein 4ADP-ribosylation factor GTPase 6 interacting protein 4ADP-ribosylation factor-like 6 interacting protein 4ADP-ribosylation-like factor 6 interacting protein 4ARL-6-interacting protein 4HSP-9 | DNA ligase 1ligase I, DNA, ATP-dependentpolydeoxyribonucleotide synthase [ATP] 1 | |
Modification date | 20200313 | 20200320 | |
UniProtAcc | Q66PJ3 | P18858 | |
Ensembl transtripts involved in fusion gene | ENST00000315580, ENST00000357866, ENST00000392435, ENST00000412505, ENST00000426960, ENST00000439686, ENST00000453766, ENST00000454885, ENST00000543566, | ||
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 6 X 5=180 |
# samples | 1 | 6 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ARL6IP4 [Title/Abstract] AND LIG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ARL6IP4(123466595)-LIG1(48668878), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | LIG1 | GO:0006284 | base-excision repair | 19589734 |
Tgene | LIG1 | GO:0033151 | V(D)J recombination | 9809069 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for ARL6IP4-LIG1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ARL6IP4-LIG1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ARL6IP4-LIG1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:123466595/:48668878) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ARL6IP4 | LIG1 |
FUNCTION: Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA. {ECO:0000269|PubMed:19582790}. | FUNCTION: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ARL6IP4-LIG1 |
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Fusion Gene PPI Analysis for ARL6IP4-LIG1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARL6IP4-LIG1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | LIG1 | P18858 | DB00290 | Bleomycin | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for ARL6IP4-LIG1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human | |
Tgene | C0005695 | Bladder Neoplasm | 1 | CTD_human | |
Tgene | C4016019 | DNA Ligase I Deficiency | 1 | GENOMICS_ENGLAND |