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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACSL5-ATE1 (FusionGDB2 ID:HG51703TG11101)

Fusion Gene Summary for ACSL5-ATE1

check button Fusion gene summary
Fusion gene informationFusion gene name: ACSL5-ATE1
Fusion gene ID: hg51703tg11101
HgeneTgene
Gene symbol

ACSL5

ATE1

Gene ID

51703

11101

Gene nameacyl-CoA synthetase long chain family member 5arginyltransferase 1
SynonymsACS2|ACS5|FACL5-
Cytomap('ACSL5')('ATE1')

10q25.2

10q26.13

Type of geneprotein-codingprotein-coding
Descriptionlong-chain-fatty-acid--CoA ligase 5FACL5 for fatty acid coenzyme A ligase 5LACS 5arachidonate--CoA ligasefatty acid coenzyme A ligase 5fatty-acid-Coenzyme A ligase, long-chain 5long-chain acyl-CoA synthetase 5long-chain fatty acid coenzyme A ligasearginyl-tRNA--protein transferase 1R-transferase 1arginine-tRNA--protein transferase 1arginyl-tRNA-protein transferase
Modification date2020031320200313
UniProtAcc

Q9ULC5

O95260

Ensembl transtripts involved in fusion geneENST00000479936, ENST00000354273, 
ENST00000354655, ENST00000356116, 
ENST00000393081, ENST00000433418, 
ENST00000369410, 
Fusion gene scores* DoF score6 X 6 X 5=18011 X 10 X 8=880
# samples 618
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/880*10)=-2.28950661719499
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACSL5 [Title/Abstract] AND ATE1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACSL5(114158767)-ATE1(123549804), # samples:2
Anticipated loss of major functional domain due to fusion event.ACSL5-ATE1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACSL5

GO:0001676

long-chain fatty acid metabolic process

24269233



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-G4-6625-01AACSL5chr10

114158767

+ATE1chr10

123549804

-


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Fusion Gene ORF analysis for ACSL5-ATE1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000479936ENST00000224652ACSL5chr10

114158767

+ATE1chr10

123549804

-
3UTR-3CDSENST00000479936ENST00000369040ACSL5chr10

114158767

+ATE1chr10

123549804

-
3UTR-3CDSENST00000479936ENST00000369043ACSL5chr10

114158767

+ATE1chr10

123549804

-
3UTR-3CDSENST00000479936ENST00000535655ACSL5chr10

114158767

+ATE1chr10

123549804

-
3UTR-3CDSENST00000479936ENST00000540606ACSL5chr10

114158767

+ATE1chr10

123549804

-
3UTR-3CDSENST00000479936ENST00000543447ACSL5chr10

114158767

+ATE1chr10

123549804

-
3UTR-intronENST00000479936ENST00000481784ACSL5chr10

114158767

+ATE1chr10

123549804

-
5CDS-intronENST00000354273ENST00000481784ACSL5chr10

114158767

+ATE1chr10

123549804

-
5CDS-intronENST00000354655ENST00000481784ACSL5chr10

114158767

+ATE1chr10

123549804

-
5CDS-intronENST00000356116ENST00000481784ACSL5chr10

114158767

+ATE1chr10

123549804

-
5CDS-intronENST00000393081ENST00000481784ACSL5chr10

114158767

+ATE1chr10

123549804

-
5CDS-intronENST00000433418ENST00000481784ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000354273ENST00000224652ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000354273ENST00000369040ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000354273ENST00000369043ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000354273ENST00000535655ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000354273ENST00000540606ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000354273ENST00000543447ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000354655ENST00000224652ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000354655ENST00000369040ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000354655ENST00000369043ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000354655ENST00000535655ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000354655ENST00000540606ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000354655ENST00000543447ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000356116ENST00000224652ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000356116ENST00000369040ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000356116ENST00000369043ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000356116ENST00000535655ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000356116ENST00000540606ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000356116ENST00000543447ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000393081ENST00000224652ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000393081ENST00000369040ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000393081ENST00000369043ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000393081ENST00000535655ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000393081ENST00000540606ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000393081ENST00000543447ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000433418ENST00000224652ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000433418ENST00000369040ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000433418ENST00000369043ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000433418ENST00000535655ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000433418ENST00000540606ACSL5chr10

114158767

+ATE1chr10

123549804

-
Frame-shiftENST00000433418ENST00000543447ACSL5chr10

114158767

+ATE1chr10

123549804

-
intron-3CDSENST00000369410ENST00000224652ACSL5chr10

114158767

+ATE1chr10

123549804

-
intron-3CDSENST00000369410ENST00000369040ACSL5chr10

114158767

+ATE1chr10

123549804

-
intron-3CDSENST00000369410ENST00000369043ACSL5chr10

114158767

+ATE1chr10

123549804

-
intron-3CDSENST00000369410ENST00000535655ACSL5chr10

114158767

+ATE1chr10

123549804

-
intron-3CDSENST00000369410ENST00000540606ACSL5chr10

114158767

+ATE1chr10

123549804

-
intron-3CDSENST00000369410ENST00000543447ACSL5chr10

114158767

+ATE1chr10

123549804

-
intron-intronENST00000369410ENST00000481784ACSL5chr10

114158767

+ATE1chr10

123549804

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ACSL5-ATE1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ACSL5-ATE1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:114158767/:123549804)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACSL5

Q9ULC5

ATE1

O95260

FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:24269233, PubMed:22633490). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. {ECO:0000250, ECO:0000269|PubMed:17681178, ECO:0000269|PubMed:18806831, ECO:0000269|PubMed:19459852, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}.FUNCTION: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ACSL5-ATE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ACSL5-ATE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACSL5-ATE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACSL5-ATE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACSL5C0003865Arthritis, Adjuvant-Induced1CTD_human
HgeneACSL5C0971858Arthritis, Collagen-Induced1CTD_human
HgeneACSL5C0993582Arthritis, Experimental1CTD_human