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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABCB1-C15orf32 (FusionGDB2 ID:HG5243TG145858)

Fusion Gene Summary for ABCB1-C15orf32

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCB1-C15orf32
Fusion gene ID: hg5243tg145858
HgeneTgene
Gene symbol

ABCB1

C15orf32

Gene ID

5243

145858

Gene nameATP binding cassette subfamily B member 1chromosome 15 putative open reading frame 32
SynonymsABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1-
Cytomap('ABCB1')('C15orf32')

7q21.12

15q26.1

Type of geneprotein-codingncRNA
DescriptionATP-dependent translocase ABCB1ATP-binding cassette, sub-family B (MDR/TAP), member 1P glycoproteinP-glycoprotein 1colchicin sensitivitydoxorubicin resistancemultidrug resistance protein 1phospholipid transporter ABCB1uncharacterized protein C15orf32
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265724, ENST00000488737, 
ENST00000543898, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: ABCB1 [Title/Abstract] AND C15orf32 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCB1(87153770)-C15orf32(93032395), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCB1

GO:0000086

G2/M transition of mitotic cell cycle

19384922

HgeneABCB1

GO:0045332

phospholipid translocation

8898203

HgeneABCB1

GO:0070633

transepithelial transport

28757552

HgeneABCB1

GO:0099040

ceramide translocation

8898203

HgeneABCB1

GO:0140115

export across plasma membrane

28587984



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for ABCB1-C15orf32

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ABCB1-C15orf32


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ABCB1-C15orf32


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:87153770/:93032395)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ABCB1-C15orf32


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ABCB1-C15orf32


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABCB1-C15orf32


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABCB1-C15orf32


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCB1C0011570Mental Depression5PSYGENET
HgeneABCB1C0011581Depressive disorder5PSYGENET
HgeneABCB1C0041696Unipolar Depression5PSYGENET
HgeneABCB1C1269683Major Depressive Disorder5PSYGENET
HgeneABCB1C0013221Drug toxicity4CTD_human
HgeneABCB1C0036341Schizophrenia4PSYGENET
HgeneABCB1C0041755Adverse reaction to drug4CTD_human
HgeneABCB1C0003873Rheumatoid Arthritis2CTD_human
HgeneABCB1C0009402Colorectal Carcinoma2CTD_human;UNIPROT
HgeneABCB1C0009404Colorectal Neoplasms2CTD_human
HgeneABCB1C0014544Epilepsy2CTD_human
HgeneABCB1C0027765nervous system disorder2CTD_human
HgeneABCB1C0027947Neutropenia2CTD_human
HgeneABCB1C0086237Epilepsy, Cryptogenic2CTD_human
HgeneABCB1C0236018Aura2CTD_human
HgeneABCB1C0751111Awakening Epilepsy2CTD_human
HgeneABCB1C0003865Arthritis, Adjuvant-Induced1CTD_human
HgeneABCB1C0004930Behavior Disorders1CTD_human
HgeneABCB1C0004936Mental disorders1CTD_human
HgeneABCB1C0006142Malignant neoplasm of breast1CTD_human
HgeneABCB1C0006826Malignant Neoplasms1CTD_human
HgeneABCB1C0006868Cannabis Abuse1CTD_human
HgeneABCB1C0006870Cannabis Dependence1CTD_human
HgeneABCB1C0007097Carcinoma1CTD_human
HgeneABCB1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneABCB1C0014836Escherichia coli Infections1CTD_human
HgeneABCB1C0014859Esophageal Neoplasms1CTD_human
HgeneABCB1C0018614Hashish Abuse1CTD_human
HgeneABCB1C0018798Congenital Heart Defects1CTD_human
HgeneABCB1C0019193Hepatitis, Toxic1CTD_human
HgeneABCB1C0020651Hypotension, Orthostatic1CTD_human
HgeneABCB1C0022665Kidney Neoplasm1CTD_human
HgeneABCB1C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneABCB1C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneABCB1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneABCB1C0024809Marijuana Abuse1CTD_human
HgeneABCB1C0027497Nausea1CTD_human
HgeneABCB1C0027627Neoplasm Metastasis1CTD_human
HgeneABCB1C0027651Neoplasms1CTD_human
HgeneABCB1C0027819Neuroblastoma1CTD_human
HgeneABCB1C0030201Pain, Postoperative1CTD_human
HgeneABCB1C0030567Parkinson Disease1CTD_human
HgeneABCB1C0030569Secondary Parkinson Disease1CTD_human
HgeneABCB1C0033975Psychotic Disorders1PSYGENET
HgeneABCB1C0040715Chromosomal translocation1CTD_human
HgeneABCB1C0042963Vomiting1CTD_human
HgeneABCB1C0079744Diffuse Large B-Cell Lymphoma1CTD_human
HgeneABCB1C0086692Benign Neoplasm1CTD_human
HgeneABCB1C0149504Encephalopathy, Toxic1CTD_human
HgeneABCB1C0154659Toxic Encephalitis1CTD_human
HgeneABCB1C0205696Anaplastic carcinoma1CTD_human
HgeneABCB1C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneABCB1C0205698Undifferentiated carcinoma1CTD_human
HgeneABCB1C0205699Carcinomatosis1CTD_human
HgeneABCB1C0206686Adrenocortical carcinoma1CTD_human
HgeneABCB1C0235032Neurotoxicity Syndromes1CTD_human
HgeneABCB1C0235874Disease Exacerbation1CTD_human
HgeneABCB1C0236735Cannabis-Related Disorder1CTD_human
HgeneABCB1C0376338Diagnosis, Psychiatric1CTD_human
HgeneABCB1C0376544Hematopoietic Neoplasms1CTD_human
HgeneABCB1C0376545Hematologic Neoplasms1CTD_human
HgeneABCB1C0546837Malignant neoplasm of esophagus1CTD_human
HgeneABCB1C0678222Breast Carcinoma1CTD_human
HgeneABCB1C0740457Malignant neoplasm of kidney1CTD_human
HgeneABCB1C0751414Parkinson Disease, Secondary Vascular1CTD_human
HgeneABCB1C0751415Atherosclerotic Parkinsonism1CTD_human
HgeneABCB1C0860207Drug-Induced Liver Disease1CTD_human
HgeneABCB1C0971858Arthritis, Collagen-Induced1CTD_human
HgeneABCB1C0993582Arthritis, Experimental1CTD_human
HgeneABCB1C1168401Squamous cell carcinoma of the head and neck1CTD_human
HgeneABCB1C1257931Mammary Neoplasms, Human1CTD_human
HgeneABCB1C1262760Hepatitis, Drug-Induced1CTD_human
HgeneABCB1C1458155Mammary Neoplasms1CTD_human
HgeneABCB1C1861502COLCHICINE RESISTANCE1ORPHANET
HgeneABCB1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneABCB1C2239176Liver carcinoma1CTD_human
HgeneABCB1C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneABCB1C4046029Mental Disorders, Severe1CTD_human
HgeneABCB1C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneABCB1C4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneABCB1C4704874Mammary Carcinoma, Human1CTD_human
HgeneABCB1C4721453Peripheral Nervous System Diseases1CTD_human