Fusion Gene Studies
in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PI4KA-FAM19A5 (FusionGDB2 ID:HG5297TG25817)

Fusion Gene Summary for PI4KA-FAM19A5

check button Fusion gene summary
Fusion gene informationFusion gene name: PI4KA-FAM19A5
Fusion gene ID: hg5297tg25817
HgeneTgene
Gene symbol

PI4KA

FAM19A5

Gene ID

5297

25817

Gene namephosphatidylinositol 4-kinase alphaTAFA chemokine like family member 5
SynonymsPI4K-ALPHA|PIK4CA|PMGYCHA|pi4K230FAM19A5|QLLK5208|TAFA-5|UNQ5208
Cytomap('PI4KA')('FAM19A5')

22q11.21

22q13.32

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol 4-kinase alphaPI4-kinase alphaphosphatidylinositol 4-kinase 230phosphatidylinositol 4-kinase III alphaphosphatidylinositol 4-kinase IIII+/-phosphatidylinositol 4-kinase, catalytic, alphaphosphatidylinositol 4-kinase, type III, achemokine-like protein TAFA-5TAFA protein 5family with sequence similarity 19 (chemokine (C-C motif)-like), member A5family with sequence similarity 19 member A5, C-C motif chemokine likeprotein FAM19A5
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000255882, ENST00000572273, 
ENST00000466162, ENST00000414196, 
Fusion gene scores* DoF score20 X 14 X 12=336010 X 7 X 6=420
# samples 2110
** MAII scorelog2(21/3360*10)=-4
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/420*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PI4KA [Title/Abstract] AND FAM19A5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPI4KA(21147481)-FAM19A5(49103529), # samples:3
Anticipated loss of major functional domain due to fusion event.PI4KA-FAM19A5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PI4KA-FAM19A5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PI4KA-FAM19A5 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PI4KA-FAM19A5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PI4KA-FAM19A5 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePI4KA

GO:0016310

phosphorylation

25327288


check buttonFusion gene breakpoints across PI4KA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FAM19A5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A12W-01API4KAchr22

21147481

-FAM19A5chr22

49103529

+


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Fusion Gene ORF analysis for PI4KA-FAM19A5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000255882ENST00000406880PI4KAchr22

21147481

-FAM19A5chr22

49103529

+
5CDS-3UTRENST00000255882ENST00000473898PI4KAchr22

21147481

-FAM19A5chr22

49103529

+
5CDS-3UTRENST00000572273ENST00000406880PI4KAchr22

21147481

-FAM19A5chr22

49103529

+
5CDS-3UTRENST00000572273ENST00000473898PI4KAchr22

21147481

-FAM19A5chr22

49103529

+
5UTR-3CDSENST00000466162ENST00000358295PI4KAchr22

21147481

-FAM19A5chr22

49103529

+
5UTR-3CDSENST00000466162ENST00000402357PI4KAchr22

21147481

-FAM19A5chr22

49103529

+
5UTR-3UTRENST00000466162ENST00000406880PI4KAchr22

21147481

-FAM19A5chr22

49103529

+
5UTR-3UTRENST00000466162ENST00000473898PI4KAchr22

21147481

-FAM19A5chr22

49103529

+
Frame-shiftENST00000255882ENST00000358295PI4KAchr22

21147481

-FAM19A5chr22

49103529

+
Frame-shiftENST00000255882ENST00000402357PI4KAchr22

21147481

-FAM19A5chr22

49103529

+
In-frameENST00000572273ENST00000358295PI4KAchr22

21147481

-FAM19A5chr22

49103529

+
In-frameENST00000572273ENST00000402357PI4KAchr22

21147481

-FAM19A5chr22

49103529

+
intron-3CDSENST00000414196ENST00000358295PI4KAchr22

21147481

-FAM19A5chr22

49103529

+
intron-3CDSENST00000414196ENST00000402357PI4KAchr22

21147481

-FAM19A5chr22

49103529

+
intron-3UTRENST00000414196ENST00000406880PI4KAchr22

21147481

-FAM19A5chr22

49103529

+
intron-3UTRENST00000414196ENST00000473898PI4KAchr22

21147481

-FAM19A5chr22

49103529

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000572273PI4KAchr2221147481-ENST00000402357FAM19A5chr2249103529+34982385572456799
ENST00000572273PI4KAchr2221147481-ENST00000358295FAM19A5chr2249103529+46072385572456799

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000572273ENST00000402357PI4KAchr2221147481-FAM19A5chr2249103529+0.0058211950.9941788
ENST00000572273ENST00000358295PI4KAchr2221147481-FAM19A5chr2249103529+0.002915580.99708444

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Fusion Genomic Features for PI4KA-FAM19A5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PI4KAchr2221147480-FAM19A5chr2249103528+1.79E-050.9999821
PI4KAchr2221147480-FAM19A5chr2249103528+1.79E-050.9999821

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PI4KA-FAM19A5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:21147481/chr22:49103529)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePI4KAchr22:21147481chr22:49103529ENST00000414196-1231530_17180855.0DomainPIK helical
HgenePI4KAchr22:21147481chr22:49103529ENST00000414196-1231846_20790855.0DomainPI3K/PI4K
HgenePI4KAchr22:21147481chr22:49103529ENST00000572273-19551530_17187182045.0DomainPIK helical
HgenePI4KAchr22:21147481chr22:49103529ENST00000572273-19551846_20797182045.0DomainPI3K/PI4K


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Fusion Gene Sequence for PI4KA-FAM19A5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>65067_65067_1_PI4KA-FAM19A5_PI4KA_chr22_21147481_ENST00000572273_FAM19A5_chr22_49103529_ENST00000358295_length(transcript)=4607nt_BP=2385nt
GGGCGCTCGCGGGCCAGGAGCGGGGAGCCGGCGGGCAGCGCCGCGGCTCGTGAGGTGATGGCGGCGGCCCCGGCCCGGGGAGGCGGAGGC
GGAGGCGGAGGCGGCGGCGGCTGCTCCGGCTCCGGCTCCAGCGCCTCGCGGGGCTTCTATTTCAACACGGTCCTGTCACTGGCCCGCTCC
CTGGCGGTGCAGAGACCAGCATCCTTGGAGAAGGTCCAAAAGCTTCTTTGCATGTGTCCAGTGGATTTCCATGGGATCTTCCAGTTAGAT
GAAAGACGGAGAGATGCAGTGATTGCATTGGGCATTTTTCTGATTGAATCTGATCTTCAGCACAAAGATTGTGTGGTTCCTTACCTTCTT
CGACTTCTCAAAGGTCTTCCAAAAGTGTATTGGGTAGAAGAAAGCACAGCTCGGAAAGGCAGAGGTGCCCTCCCGGTTGCAGAGAGCTTC
AGCTTCTGCTTGGTAACTCTGCTGTCTGATGTGGCCTATAGGGATCCTTCACTTAGGGATGAGATTTTAGAGGTGCTTTTGCAGGTTTTG
CATGTCCTCTTGGGGATGTGCCAGGCCTTGGAGATTCAAGACAAAGAATACCTTTGCAAGTATGCTATCCCATGCCTGATAGGAATCTCG
CGAGCATTTGGGCGTTACAGCAACATGGAAGAGTCTCTCCTCTCAAAGCTCTTTCCCAAAATCCCTCCTCATTCCCTCCGTGTCCTGGAA
GAGCTTGAAGGTGTTCGAAGGCGTTCCTTTAATGACTTCCGCTCCATCCTCCCCAGCAATCTGCTGACTGTCTGTCAGGAGGGTACCCTG
AAGAGGAAAACCAGCAGTGTGTCCAGCATCTCTCAGGTCAGCCCTGAACGCGGCATGCCCCCTCCCAGTTCCCCTGGAGGATCTGCCTTT
CACTACTTTGAAGCCTCCTGCTTGCCCGATGGGACTGCCCTAGAGCCTGAGTACTACTTTTCAACCATCAGCTCCAGCTTCTCAGTCTCT
CCCCTTTTCAACGGTGTCACATATAAGGAGTTTAACATTCCATTGGAAATGCTTCGGGAACTCTTAAACCTGGTGAAGAAGATCGTTGAG
GAGGCTGTTCTCAAATCTTTGGATGCCATTGTAGCCAGTGTGATGGAGGCCAACCCCAGTGCTGATCTCTACTACACTTCCTTCAGTGAC
CCTCTCTACCTGACCATGTTCAAGATGCTGCGTGACACTCTGTACTACATGAAGGACCTCCCGACCTCTTTTGTGAAGGAGATCCATGAT
TTTGTGCTGGAGCAGTTCAACACGAGCCAGGGGGAGCTCCAGAAGATTCTACATGACGCAGACCGGATCCACAATGAGCTGAGCCCCCTC
AAACTGCGCTGTCAGGCGAATGCTGCCTGTGTGGACCTCATGGTGTGGGCTGTGAAGGACGAGCAGGGTGCAGAAAACCTTTGCATCAAG
CTATCTGAGAAGCTGCAGTCCAAGACGTCCAGCAAAGTCATTATTGCTCACTTGCCCCTGCTGATCTGCTGTCTGCAGGGTTTGGGCCGC
CTGTGCGAGAGGTTCCCGGTGGTGGTGCACTCTGTGACACCGTCCTTGCGAGACTTCCTGGTCATCCCGTCCCCAGTTCTGGTGAAGCTC
TACAAGTACCACAGTCAGTACCACACAGTTGCTGGCAATGATATAAAAATCAGTGTGACCAATGAGCATTCCGAGTCAACCCTGAACGTC
ATGTCGGGTAAGAAGAGCCAGCCCTCCATGTACGAGCAGCTCCGAGACATCGCTATTGACAACATCTGCAGGTGCCTGAAGGCTGGATTG
ACGGTGGACCCAGTGATTGTGGAGGCGTTCTTGGCCAGCCTGTCCAACCGGCTCTACATCTCTCAGGAGAGCGACAAGGACGCTCACTTG
ATTCCCGACCACACAATCCGAGCCTTGGGACACATTGCGGTGGCCTTGAGGGACACCCCGAAGGTCATGGAGCCCATTCTGCAGATCCTA
CAGCAGAAATTCTGCCAGCCACCCTCCCCCCTCGATGTGCTGATTATTGACCAGCTGGGCTGCCTGGTTATCACCGGAAATCAATACATC
TATCAGGAAGTGTGGAACCTCTTCCAGCAGATCAGTGTGAAGGCCAGCTCCGTTGTATACTCAGCCACCAAAGATTACAAGGACCACGGC
TATAGGCATTGCTCCCTGGCAGTGATTAATGCCCTGGCCAACATCGCGGCCAACATCCAAGACGAGCACCTGGTGGATGAGCTGCTCATG
AACCTGTTGGAGTTGTTTGTGCAGCTGGGGCTGGAGGGGAAGCGAGCCAGCGAGAGGGCAAGCGAGAAGGGCCCTGCCCTAAAGGCTTCT
AGCAGTGCAGGGAACTTGGGAGTACTCATTCCTGTAATAGCTGTGCAAGAATCATCAAGACCAAGCAGTGGTGTGACATGCTTCCGTGTC
TGGAGGGGGAAGGCTGCGACTTGTTAATCAACCGGTCAGGCTGGACGTGCACGCAGCCCGGCGGGAGGATAAAGACCACCACGGTCTCCT
GACAAACACAGCCCCTGAGGGGCCCCGGGAGTGGCCTTGGCTCCCTGGAGAGCCCACGTCTCAGCCACAGTTCTCCACTCGCCTCGGACT
TCACCCGTTCTCTGCCGCCCGCCCACTCCGTTTCCCTGTGGTCCGTGAAGGACGGCCTCAGGCCTTGGCATCCTGAGCTTCGGTCTGTCC
AGCCGACCCGAGGAGGCCGGACTCAGACACATAGGCGGGGGGCGGCACCTGGCATCAGCAATACGCAGTCTGTGGGAGCCCGGCCGCGCC
CAGCCCCCGCCGACCGTGGCGTTGGCCCTGCTGTCCTCAGAGGAGGAGGAGGAGGAGGCAGCTCCGGCAGCCACAGAAGGCTGCAGCCCA
GCCCGCCTGAGACACGACGCCTGCCCCAGGGGACTGTCAGGCACAGAAGCGGCCTCCTCCCGTGCCCCAGACTGTCCGAATTGCTTTTAT
TTTCTTATACTTTCAGTATACTCCATAGACCAAAGAGCAAAATCTATCTGAACCTGGACGCACCCTCACTGTCAGGGTCCCTGGGGTCGC
TTGTGCGGGCGGGAGGGCAATGGTGGCAGAGACATGCTGGTGGCCCCGGCGGAGCGGAGAGGGCGGCCGTGGTGGAGGCCTCCACCCCAG
GAGCACCCCGCGCACCCTCGGAGGACGGGCTTCGGCTGCGCGGAGGCCGTGGCACACCTGCGGGAGGCAGCGACGGCCCCCACGCAGACG
CCGGGAACGCAGGCCGCTTTATTCCTCTGTACTTAGATCAACTTGACCGTACTAAAATCCCTTTCTGTTTTAACCAGTTAAACATGCCTC
TTCTACAGCTCCATTTTTGATAGTTGGATAATCCAGTATCTGCCAAGAGCATGTTGGGTCTCCCGTGACTGCTGCCTCATCGATACCCCA
TTTAGCTCCAGAAAGCAAAGAAAACTCGAGTAACACTTGTTTGAAAGAGATCATTAAATGTATTTTGCAAAGCCTAAAGTTATATATTTA
ACAGTTTTTATATGTTGTATATTTGTAGAAAATCCTATTTAACAATTAACGTGGCAGTCCCGGCCGTCCTGAGAGTCGGGCCGAGCCCCG
TGTGTTTCTGAAGACTCTGGGGGTGGGACACGGCGGGGAGGTGGTGCCCCGCGGACCCCGGGGTGCCAGGCACGGAAGGCGGGACTCTGG
GAGAAGCGTGCGGAGGACCGTGGCGTCGGCGTCCCGGATGTGTCGGTCGTGCCCGGGGAGGCCGGGTTCCCCTCGCTGCGGGCCAGGCTT
GGCTCCTGATTCCCTCTCTGGTCCCTGTATTGGTCAACACTTGAGCGTACAATATCTTGAACATGCTTCTTCCAATGGGTTTTGTTTCCC
ATTTCCTGCCCCTTTCGCCACTCACGGACCTTGAGGCCAGTTGACGGCCCTTCTCCCCACGCCTGTGTCCCCGCGTTCTGAGAAGTCCTC
TGTCTTCGTGTCACTAGGTCCAGAAAGTCGCGCCGGGCAGAGGCGCAGGCGGGGCCGGCAGGGCCGAGGAATAAGCGACAATTCTGGTTT
TTCTCCCCTGGCCGTCGTTCGCCAGCCTCCTTCATTTTCCTGAGTTCCCGCTGAAGTATATACTACCTATGAGTCCAATTAACATGAGTA
TTATGCTAGTTCTATCCTACTAAAAAAAACGTAAAAAAATAACTATATAGAAGCTGTTCCAGCAACCATAGACTGAAGATACGAAAGAAA
ATCCATTTATTTAAGACCTGTTCCGGTATCCATGAGGACATAATTTACCTTTCAGTCACCACAAATTTATAGGCATTTGTATCCTGGACT
AAAAGAAGGGGCTGAGGTTGGGTTTGTCATCACAGAGGGGGTGGGCCTGGAAAGGGTCCTTCCCAAGCTGCCCCGGCTCCGGCGGCCCGG
GCCGGCAGCCTCTGCCAGCCAGCGTCCTCACGGCCTCCCCCTCGCCTGTTTCTTTTGAAAGCAAGTGTAGACACCTTCGAGGGCAGAGAT
CGGGAGATTTAAGATGTTACAGCATATTTTTTTTTCTTGTTTTACAGTATTCAATTTTGTGTTGATTCAGCTAAATTATGAAAAATAAAG

>65067_65067_1_PI4KA-FAM19A5_PI4KA_chr22_21147481_ENST00000572273_FAM19A5_chr22_49103529_ENST00000358295_length(amino acids)=799AA_BP=776
MAAAPARGGGGGGGGGGGCSGSGSSASRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDL
QHKDCVVPYLLRLLKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQDKEYLC
KYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGM
PPPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANP
SADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHDADRIHNELSPLKLRCQANAACVDLMVWAVK
DEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISV
TNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDT
PKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANI

--------------------------------------------------------------
>65067_65067_2_PI4KA-FAM19A5_PI4KA_chr22_21147481_ENST00000572273_FAM19A5_chr22_49103529_ENST00000402357_length(transcript)=3498nt_BP=2385nt
GGGCGCTCGCGGGCCAGGAGCGGGGAGCCGGCGGGCAGCGCCGCGGCTCGTGAGGTGATGGCGGCGGCCCCGGCCCGGGGAGGCGGAGGC
GGAGGCGGAGGCGGCGGCGGCTGCTCCGGCTCCGGCTCCAGCGCCTCGCGGGGCTTCTATTTCAACACGGTCCTGTCACTGGCCCGCTCC
CTGGCGGTGCAGAGACCAGCATCCTTGGAGAAGGTCCAAAAGCTTCTTTGCATGTGTCCAGTGGATTTCCATGGGATCTTCCAGTTAGAT
GAAAGACGGAGAGATGCAGTGATTGCATTGGGCATTTTTCTGATTGAATCTGATCTTCAGCACAAAGATTGTGTGGTTCCTTACCTTCTT
CGACTTCTCAAAGGTCTTCCAAAAGTGTATTGGGTAGAAGAAAGCACAGCTCGGAAAGGCAGAGGTGCCCTCCCGGTTGCAGAGAGCTTC
AGCTTCTGCTTGGTAACTCTGCTGTCTGATGTGGCCTATAGGGATCCTTCACTTAGGGATGAGATTTTAGAGGTGCTTTTGCAGGTTTTG
CATGTCCTCTTGGGGATGTGCCAGGCCTTGGAGATTCAAGACAAAGAATACCTTTGCAAGTATGCTATCCCATGCCTGATAGGAATCTCG
CGAGCATTTGGGCGTTACAGCAACATGGAAGAGTCTCTCCTCTCAAAGCTCTTTCCCAAAATCCCTCCTCATTCCCTCCGTGTCCTGGAA
GAGCTTGAAGGTGTTCGAAGGCGTTCCTTTAATGACTTCCGCTCCATCCTCCCCAGCAATCTGCTGACTGTCTGTCAGGAGGGTACCCTG
AAGAGGAAAACCAGCAGTGTGTCCAGCATCTCTCAGGTCAGCCCTGAACGCGGCATGCCCCCTCCCAGTTCCCCTGGAGGATCTGCCTTT
CACTACTTTGAAGCCTCCTGCTTGCCCGATGGGACTGCCCTAGAGCCTGAGTACTACTTTTCAACCATCAGCTCCAGCTTCTCAGTCTCT
CCCCTTTTCAACGGTGTCACATATAAGGAGTTTAACATTCCATTGGAAATGCTTCGGGAACTCTTAAACCTGGTGAAGAAGATCGTTGAG
GAGGCTGTTCTCAAATCTTTGGATGCCATTGTAGCCAGTGTGATGGAGGCCAACCCCAGTGCTGATCTCTACTACACTTCCTTCAGTGAC
CCTCTCTACCTGACCATGTTCAAGATGCTGCGTGACACTCTGTACTACATGAAGGACCTCCCGACCTCTTTTGTGAAGGAGATCCATGAT
TTTGTGCTGGAGCAGTTCAACACGAGCCAGGGGGAGCTCCAGAAGATTCTACATGACGCAGACCGGATCCACAATGAGCTGAGCCCCCTC
AAACTGCGCTGTCAGGCGAATGCTGCCTGTGTGGACCTCATGGTGTGGGCTGTGAAGGACGAGCAGGGTGCAGAAAACCTTTGCATCAAG
CTATCTGAGAAGCTGCAGTCCAAGACGTCCAGCAAAGTCATTATTGCTCACTTGCCCCTGCTGATCTGCTGTCTGCAGGGTTTGGGCCGC
CTGTGCGAGAGGTTCCCGGTGGTGGTGCACTCTGTGACACCGTCCTTGCGAGACTTCCTGGTCATCCCGTCCCCAGTTCTGGTGAAGCTC
TACAAGTACCACAGTCAGTACCACACAGTTGCTGGCAATGATATAAAAATCAGTGTGACCAATGAGCATTCCGAGTCAACCCTGAACGTC
ATGTCGGGTAAGAAGAGCCAGCCCTCCATGTACGAGCAGCTCCGAGACATCGCTATTGACAACATCTGCAGGTGCCTGAAGGCTGGATTG
ACGGTGGACCCAGTGATTGTGGAGGCGTTCTTGGCCAGCCTGTCCAACCGGCTCTACATCTCTCAGGAGAGCGACAAGGACGCTCACTTG
ATTCCCGACCACACAATCCGAGCCTTGGGACACATTGCGGTGGCCTTGAGGGACACCCCGAAGGTCATGGAGCCCATTCTGCAGATCCTA
CAGCAGAAATTCTGCCAGCCACCCTCCCCCCTCGATGTGCTGATTATTGACCAGCTGGGCTGCCTGGTTATCACCGGAAATCAATACATC
TATCAGGAAGTGTGGAACCTCTTCCAGCAGATCAGTGTGAAGGCCAGCTCCGTTGTATACTCAGCCACCAAAGATTACAAGGACCACGGC
TATAGGCATTGCTCCCTGGCAGTGATTAATGCCCTGGCCAACATCGCGGCCAACATCCAAGACGAGCACCTGGTGGATGAGCTGCTCATG
AACCTGTTGGAGTTGTTTGTGCAGCTGGGGCTGGAGGGGAAGCGAGCCAGCGAGAGGGCAAGCGAGAAGGGCCCTGCCCTAAAGGCTTCT
AGCAGTGCAGGGAACTTGGGAGTACTCATTCCTGTAATAGCTGTGCAAGAATCATCAAGACCAAGCAGTGGTGTGACATGCTTCCGTGTC
TGGAGGGGGAAGGCTGCGACTTGTTAATCAACCGGTCAGGCTGGACGTGCACGCAGCCCGGCGGGAGGATAAAGACCACCACGGTCTCCT
GACAAACACAGCCCCTGAGGGGCCCCGGGAGTGGCCTTGGCTCCCTGGAGAGCCCACGTCTCAGCCACAGTTCTCCACTCGCCTCGGACT
TCACCCGTTCTCTGCCGCCCGCCCACTCCGTTTCCCTGTGGTCCGTGAAGGACGGCCTCAGGCCTTGGCATCCTGAGCTTCGGTCTGTCC
AGCCGACCCGAGGAGGCCGGACTCAGACACATAGGCGGGGGGCGGCACCTGGCATCAGCAATACGCAGTCTGTGGGAGCCCGGCCGCGCC
CAGCCCCCGCCGACCGTGGCGTTGGCCCTGCTGTCCTCAGAGGAGGAGGAGGAGGAGGCAGCTCCGGCAGCCACAGAAGGCTGCAGCCCA
GCCCGCCTGAGACACGACGCCTGCCCCAGGGGACTGTCAGGCACAGAAGCGGCCTCCTCCCGTGCCCCAGACTGTCCGAATTGCTTTTAT
TTTCTTATACTTTCAGTATACTCCATAGACCAAAGAGCAAAATCTATCTGAACCTGGACGCACCCTCACTGTCAGGGTCCCTGGGGTCGC
TTGTGCGGGCGGGAGGGCAATGGTGGCAGAGACATGCTGGTGGCCCCGGCGGAGCGGAGAGGGCGGCCGTGGTGGAGGCCTCCACCCCAG
GAGCACCCCGCGCACCCTCGGAGGACGGGCTTCGGCTGCGCGGAGGCCGTGGCACACCTGCGGGAGGCAGCGACGGCCCCCACGCAGACG
CCGGGAACGCAGGCCGCTTTATTCCTCTGTACTTAGATCAACTTGACCGTACTAAAATCCCTTTCTGTTTTAACCAGTTAAACATGCCTC
TTCTACAGCTCCATTTTTGATAGTTGGATAATCCAGTATCTGCCAAGAGCATGTTGGGTCTCCCGTGACTGCTGCCTCATCGATACCCCA

>65067_65067_2_PI4KA-FAM19A5_PI4KA_chr22_21147481_ENST00000572273_FAM19A5_chr22_49103529_ENST00000402357_length(amino acids)=799AA_BP=776
MAAAPARGGGGGGGGGGGCSGSGSSASRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDL
QHKDCVVPYLLRLLKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQDKEYLC
KYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGM
PPPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANP
SADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHDADRIHNELSPLKLRCQANAACVDLMVWAVK
DEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISV
TNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDT
PKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANI

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Fusion Gene PPI Analysis for PI4KA-FAM19A5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PI4KA-FAM19A5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PI4KA-FAM19A5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePI4KAC0036341Schizophrenia4PSYGENET
HgenePI4KAC1845668Perisylvian syndrome1ORPHANET
HgenePI4KAC4225295POLYMICROGYRIA, PERISYLVIAN, WITH CEREBELLAR HYPOPLASIA AND ARTHROGRYPOSIS1GENOMICS_ENGLAND;UNIPROT