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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACP1-SH3YL1 (FusionGDB2 ID:HG52TG26751)

Fusion Gene Summary for ACP1-SH3YL1

check button Fusion gene summary
Fusion gene informationFusion gene name: ACP1-SH3YL1
Fusion gene ID: hg52tg26751
HgeneTgene
Gene symbol

ACP1

SH3YL1

Gene ID

52

26751

Gene nameacid phosphatase 1SH3 and SYLF domain containing 1
SynonymsHAAP|LMW-PTP|LMWPTPRAY
Cytomap('ACP1')('SH3YL1')

2p25.3

2p25.3

Type of geneprotein-codingprotein-coding
Descriptionlow molecular weight phosphotyrosine protein phosphataseLMW-PTPaseacid phosphatase 1, solubleacid phosphatase of erythrocyteadipocyte acid phosphatasecytoplasmic phosphotyrosyl protein phosphataselow molecular weight cytosolic acid phosphataseproteSH3 domain-containing YSC84-like protein 1SH3 domain containing, Ysc84-like 1
Modification date2020031320200313
UniProtAcc

P24666

.
Ensembl transtripts involved in fusion geneENST00000484464, ENST00000272065, 
ENST00000407983, ENST00000272067, 
ENST00000405233, ENST00000439645, 
ENST00000484464, ENST00000272065, 
ENST00000272067, ENST00000405233, 
ENST00000407983, ENST00000439645, 
Fusion gene scores* DoF score4 X 4 X 3=4810 X 5 X 4=200
# samples 410
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/200*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACP1 [Title/Abstract] AND SH3YL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACP1(272150)-SH3YL1(230044), # samples:1
Anticipated loss of major functional domain due to fusion event.ACP1-SH3YL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACP1-SH3YL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACP1-SH3YL1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ACP1-SH3YL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SH3YL1-ACP1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SH3YL1-ACP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ACP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SH3YL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4H2ACP1chr2

272150

+SH3YL1chr2

230044

-


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Fusion Gene ORF analysis for ACP1-SH3YL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000484464ENST00000356150ACP1chr2

272150

+SH3YL1chr2

230044

-
3UTR-3CDSENST00000484464ENST00000403658ACP1chr2

272150

+SH3YL1chr2

230044

-
3UTR-3CDSENST00000484464ENST00000403712ACP1chr2

272150

+SH3YL1chr2

230044

-
3UTR-3CDSENST00000484464ENST00000405430ACP1chr2

272150

+SH3YL1chr2

230044

-
3UTR-5UTRENST00000484464ENST00000468321ACP1chr2

272150

+SH3YL1chr2

230044

-
3UTR-intronENST00000484464ENST00000402632ACP1chr2

272150

+SH3YL1chr2

230044

-
3UTR-intronENST00000484464ENST00000403657ACP1chr2

272150

+SH3YL1chr2

230044

-
3UTR-intronENST00000484464ENST00000415006ACP1chr2

272150

+SH3YL1chr2

230044

-
5CDS-5UTRENST00000272065ENST00000468321ACP1chr2

272150

+SH3YL1chr2

230044

-
5CDS-5UTRENST00000407983ENST00000468321ACP1chr2

272150

+SH3YL1chr2

230044

-
5CDS-intronENST00000272065ENST00000402632ACP1chr2

272150

+SH3YL1chr2

230044

-
5CDS-intronENST00000272065ENST00000403657ACP1chr2

272150

+SH3YL1chr2

230044

-
5CDS-intronENST00000272065ENST00000415006ACP1chr2

272150

+SH3YL1chr2

230044

-
5CDS-intronENST00000407983ENST00000402632ACP1chr2

272150

+SH3YL1chr2

230044

-
5CDS-intronENST00000407983ENST00000403657ACP1chr2

272150

+SH3YL1chr2

230044

-
5CDS-intronENST00000407983ENST00000415006ACP1chr2

272150

+SH3YL1chr2

230044

-
Frame-shiftENST00000407983ENST00000356150ACP1chr2

272150

+SH3YL1chr2

230044

-
Frame-shiftENST00000407983ENST00000403658ACP1chr2

272150

+SH3YL1chr2

230044

-
Frame-shiftENST00000407983ENST00000403712ACP1chr2

272150

+SH3YL1chr2

230044

-
Frame-shiftENST00000407983ENST00000405430ACP1chr2

272150

+SH3YL1chr2

230044

-
In-frameENST00000272065ENST00000356150ACP1chr2

272150

+SH3YL1chr2

230044

-
In-frameENST00000272065ENST00000403658ACP1chr2

272150

+SH3YL1chr2

230044

-
In-frameENST00000272065ENST00000403712ACP1chr2

272150

+SH3YL1chr2

230044

-
In-frameENST00000272065ENST00000405430ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-3CDSENST00000272067ENST00000356150ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-3CDSENST00000272067ENST00000403658ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-3CDSENST00000272067ENST00000403712ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-3CDSENST00000272067ENST00000405430ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-3CDSENST00000405233ENST00000356150ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-3CDSENST00000405233ENST00000403658ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-3CDSENST00000405233ENST00000403712ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-3CDSENST00000405233ENST00000405430ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-3CDSENST00000439645ENST00000356150ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-3CDSENST00000439645ENST00000403658ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-3CDSENST00000439645ENST00000403712ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-3CDSENST00000439645ENST00000405430ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-5UTRENST00000272067ENST00000468321ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-5UTRENST00000405233ENST00000468321ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-5UTRENST00000439645ENST00000468321ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-intronENST00000272067ENST00000402632ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-intronENST00000272067ENST00000403657ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-intronENST00000272067ENST00000415006ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-intronENST00000405233ENST00000402632ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-intronENST00000405233ENST00000403657ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-intronENST00000405233ENST00000415006ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-intronENST00000439645ENST00000402632ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-intronENST00000439645ENST00000403657ACP1chr2

272150

+SH3YL1chr2

230044

-
intron-intronENST00000439645ENST00000415006ACP1chr2

272150

+SH3YL1chr2

230044

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ACP1-SH3YL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ACP1-SH3YL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:272150/chr2:230044)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACP1

P24666

.
FUNCTION: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSH3YL1chr2:272150chr2:230044ENST00000356150610283_342234343.0DomainSH3
TgeneSH3YL1chr2:272150chr2:230044ENST0000040263207283_3420945.3333333333334DomainSH3
TgeneSH3YL1chr2:272150chr2:230044ENST00000403657912283_342138228.0DomainSH3
TgeneSH3YL1chr2:272150chr2:230044ENST00000403658811283_342138228.0DomainSH3
TgeneSH3YL1chr2:272150chr2:230044ENST0000040371269283_342234324.0DomainSH3
TgeneSH3YL1chr2:272150chr2:230044ENST00000405430812283_342234343.0DomainSH3
TgeneSH3YL1chr2:272150chr2:230044ENST0000041500637283_342138247.0DomainSH3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ACP1-SH3YL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ACP1-SH3YL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACP1-SH3YL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneACP1P24666DB00173AdenineSmall moleculeApproved|Nutraceutical

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Related Diseases for ACP1-SH3YL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACP1C0036341Schizophrenia1PSYGENET
HgeneACP1C0041696Unipolar Depression1PSYGENET
HgeneACP1C1269683Major Depressive Disorder1PSYGENET