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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BTBD1-CSTF3 (FusionGDB2 ID:HG53339TG1479)

Fusion Gene Summary for BTBD1-CSTF3

check button Fusion gene summary
Fusion gene informationFusion gene name: BTBD1-CSTF3
Fusion gene ID: hg53339tg1479
HgeneTgene
Gene symbol

BTBD1

CSTF3

Gene ID

53339

1479

Gene nameBTB domain containing 1cleavage stimulation factor subunit 3
SynonymsC15orf1|NS5ATP8CSTF-77
Cytomap('BTBD1')('CSTF3')

15q25.2

11p13

Type of geneprotein-codingprotein-coding
DescriptionBTB/POZ domain-containing protein 1BTB (POZ) domain containing 1HCV NS5A-transactivated protein 8hepatitis C virus NS5A-transactivated protein 8cleavage stimulation factor subunit 3CF-1 77 kDa subunitCSTF 77 kDa subunitcleavage stimulation factor 77 kDa subunitcleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDcleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
Modification date2020032720200313
UniProtAcc.

Q12996

Ensembl transtripts involved in fusion geneENST00000261721, ENST00000379403, 
ENST00000560015, 
Fusion gene scores* DoF score11 X 9 X 9=8917 X 4 X 6=168
# samples 138
** MAII scorelog2(13/891*10)=-2.77691380849347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BTBD1 [Title/Abstract] AND CSTF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBTBD1(83725140)-CSTF3(33163532), # samples:1
Anticipated loss of major functional domain due to fusion event.BTBD1-CSTF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD1-CSTF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD1-CSTF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD1-CSTF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across BTBD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CSTF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AX-A3FSBTBD1chr15

83725140

-CSTF3chr11

33163532

-


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Fusion Gene ORF analysis for BTBD1-CSTF3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000261721ENST00000431742BTBD1chr15

83725140

-CSTF3chr11

33163532

-
5CDS-5UTRENST00000261721ENST00000438862BTBD1chr15

83725140

-CSTF3chr11

33163532

-
5CDS-5UTRENST00000261721ENST00000526480BTBD1chr15

83725140

-CSTF3chr11

33163532

-
5CDS-5UTRENST00000379403ENST00000431742BTBD1chr15

83725140

-CSTF3chr11

33163532

-
5CDS-5UTRENST00000379403ENST00000438862BTBD1chr15

83725140

-CSTF3chr11

33163532

-
5CDS-5UTRENST00000379403ENST00000526480BTBD1chr15

83725140

-CSTF3chr11

33163532

-
In-frameENST00000261721ENST00000323959BTBD1chr15

83725140

-CSTF3chr11

33163532

-
In-frameENST00000261721ENST00000524827BTBD1chr15

83725140

-CSTF3chr11

33163532

-
In-frameENST00000379403ENST00000323959BTBD1chr15

83725140

-CSTF3chr11

33163532

-
In-frameENST00000379403ENST00000524827BTBD1chr15

83725140

-CSTF3chr11

33163532

-
intron-3CDSENST00000560015ENST00000323959BTBD1chr15

83725140

-CSTF3chr11

33163532

-
intron-3CDSENST00000560015ENST00000524827BTBD1chr15

83725140

-CSTF3chr11

33163532

-
intron-5UTRENST00000560015ENST00000431742BTBD1chr15

83725140

-CSTF3chr11

33163532

-
intron-5UTRENST00000560015ENST00000438862BTBD1chr15

83725140

-CSTF3chr11

33163532

-
intron-5UTRENST00000560015ENST00000526480BTBD1chr15

83725140

-CSTF3chr11

33163532

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000261721BTBD1chr1583725140-ENST00000323959CSTF3chr1133163532-33917612032887894
ENST00000261721BTBD1chr1583725140-ENST00000524827CSTF3chr1133163532-11967612031195331
ENST00000379403BTBD1chr1583725140-ENST00000323959CSTF3chr1133163532-318855802684894
ENST00000379403BTBD1chr1583725140-ENST00000524827CSTF3chr1133163532-9935580992330

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261721ENST00000323959BTBD1chr1583725140-CSTF3chr1133163532-0.0007187850.9992812
ENST00000261721ENST00000524827BTBD1chr1583725140-CSTF3chr1133163532-0.0018577250.99814224
ENST00000379403ENST00000323959BTBD1chr1583725140-CSTF3chr1133163532-0.0007715220.9992285
ENST00000379403ENST00000524827BTBD1chr1583725140-CSTF3chr1133163532-0.0013919310.99860805

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Fusion Genomic Features for BTBD1-CSTF3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BTBD1-CSTF3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:83725140/chr11:33163532)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CSTF3

Q12996

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBTBD1chr15:83725140chr11:33163532ENST00000261721-2825_31186483.0Compositional biasPoly-Pro
HgeneBTBD1chr15:83725140chr11:33163532ENST00000379403-2725_31186337.3333333333333Compositional biasPoly-Pro
HgeneBTBD1chr15:83725140chr11:33163532ENST00000261721-2869_145186483.0DomainBTB
HgeneBTBD1chr15:83725140chr11:33163532ENST00000379403-2769_145186337.3333333333333DomainBTB
TgeneCSTF3chr15:83725140chr11:33163532ENST00000323959021559_6269718.0Compositional biasNote=Pro-rich
TgeneCSTF3chr15:83725140chr11:33163532ENST0000043174202559_626945.0Compositional biasNote=Pro-rich
TgeneCSTF3chr15:83725140chr11:33163532ENST0000043886203559_6269104.0Compositional biasNote=Pro-rich
TgeneCSTF3chr15:83725140chr11:33163532ENST00000323959021117_1529718.0RepeatNote=HAT 3
TgeneCSTF3chr15:83725140chr11:33163532ENST00000323959021163_1969718.0RepeatNote=HAT 4
TgeneCSTF3chr15:83725140chr11:33163532ENST00000323959021221_2619718.0RepeatNote=HAT 5
TgeneCSTF3chr15:83725140chr11:33163532ENST00000323959021271_3039718.0RepeatNote=HAT 6
TgeneCSTF3chr15:83725140chr11:33163532ENST00000323959021319_3529718.0RepeatNote=HAT 7
TgeneCSTF3chr15:83725140chr11:33163532ENST00000323959021354_3879718.0RepeatNote=HAT 8
TgeneCSTF3chr15:83725140chr11:33163532ENST00000323959021458_4949718.0RepeatNote=HAT 9
TgeneCSTF3chr15:83725140chr11:33163532ENST0000032395902145_779718.0RepeatNote=HAT 1
TgeneCSTF3chr15:83725140chr11:33163532ENST0000032395902179_1109718.0RepeatNote=HAT 2
TgeneCSTF3chr15:83725140chr11:33163532ENST0000043174202117_152945.0RepeatNote=HAT 3
TgeneCSTF3chr15:83725140chr11:33163532ENST0000043174202163_196945.0RepeatNote=HAT 4
TgeneCSTF3chr15:83725140chr11:33163532ENST0000043174202221_261945.0RepeatNote=HAT 5
TgeneCSTF3chr15:83725140chr11:33163532ENST0000043174202271_303945.0RepeatNote=HAT 6
TgeneCSTF3chr15:83725140chr11:33163532ENST0000043174202319_352945.0RepeatNote=HAT 7
TgeneCSTF3chr15:83725140chr11:33163532ENST0000043174202354_387945.0RepeatNote=HAT 8
TgeneCSTF3chr15:83725140chr11:33163532ENST0000043174202458_494945.0RepeatNote=HAT 9
TgeneCSTF3chr15:83725140chr11:33163532ENST000004317420245_77945.0RepeatNote=HAT 1
TgeneCSTF3chr15:83725140chr11:33163532ENST000004317420279_110945.0RepeatNote=HAT 2
TgeneCSTF3chr15:83725140chr11:33163532ENST0000043886203117_1529104.0RepeatNote=HAT 3
TgeneCSTF3chr15:83725140chr11:33163532ENST0000043886203163_1969104.0RepeatNote=HAT 4
TgeneCSTF3chr15:83725140chr11:33163532ENST0000043886203221_2619104.0RepeatNote=HAT 5
TgeneCSTF3chr15:83725140chr11:33163532ENST0000043886203271_3039104.0RepeatNote=HAT 6
TgeneCSTF3chr15:83725140chr11:33163532ENST0000043886203319_3529104.0RepeatNote=HAT 7
TgeneCSTF3chr15:83725140chr11:33163532ENST0000043886203354_3879104.0RepeatNote=HAT 8
TgeneCSTF3chr15:83725140chr11:33163532ENST0000043886203458_4949104.0RepeatNote=HAT 9
TgeneCSTF3chr15:83725140chr11:33163532ENST000004388620345_779104.0RepeatNote=HAT 1
TgeneCSTF3chr15:83725140chr11:33163532ENST000004388620379_1109104.0RepeatNote=HAT 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBTBD1chr15:83725140chr11:33163532ENST00000261721-28184_284186483.0DomainBACK
HgeneBTBD1chr15:83725140chr11:33163532ENST00000379403-27184_284186337.3333333333333DomainBACK


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Fusion Gene Sequence for BTBD1-CSTF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10440_10440_1_BTBD1-CSTF3_BTBD1_chr15_83725140_ENST00000261721_CSTF3_chr11_33163532_ENST00000323959_length(transcript)=3391nt_BP=761nt
AGTCCTGTTACACCTCCCGCGGCCGCGCACAGCGGCAACCCGGGCGTGCGGGGGCGCGCGCGGTCAGGGAGGGGCCTGCGGAGGCGCGAG
GCCCCCGGAAGCGCCTTTCCCGGAAGGCAGGGAGGCAGCGCCGGCCTCCGGAGGCGGCCTGGGCGATGGCGGCGGAGTTTTGTCCATAAC
GTGGGCAACCGCGCAGCTGGAGGATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCG
CGGGGCCGCCGCCGCCGCCCTCACCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGG
CGTCGCTGAAGGAGCGCTTCGCCTTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCG
CCGCTGGGGGCCCGCAGCGCATCCCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGG
CCACCACGTCGGCCGAGATCGAGCTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAA
TTGGTCCAGAAACAGTTATGACCACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCA
AACATCTTAGGGCAGATAATGCCTTTATGTTACTTACTCAGGCAGCTGAGTATGTCCCAGAGAAGGTGAAGAAAGCGGAAAAGAAATTAG
AAGAGAATCCATATGACCTTGATGCTTGGAGCATTCTCATTCGAGAGGCACAGAATCAACCTATAGACAAAGCACGGAAGACTTATGAAC
GCCTTGTTGCCCAGTTCCCCAGTTCTGGCAGATTCTGGAAACTGTACATTGAAGCAGAGATTAAAGCTAAAAATTATGACAAGGTTGAAA
AGCTATTTCAGAGATGCCTTATGAAGGTTTTGCACATTGATTTATGGAAGTGTTATCTTTCATATGTCCGAGAAACCAAGGGTAAACTAC
CAAGTTACAAAGAAAAAATGGCTCAAGCATATGACTTTGCACTGGATAAAATTGGAATGGAAATTATGTCCTATCAGATTTGGGTGGATT
ACATCAATTTCCTAAAAGGCGTGGAAGCTGTAGGATCTTATGCAGAAAATCAAAGAATAACAGCTGTCCGAAGAGTTTATCAACGAGGTT
GTGTTAATCCGATGATCAACATTGAACAGCTCTGGAGAGACTATAACAAGTATGAAGAGGGTATCAATATTCATTTAGCTAAAAAAATGA
TTGAAGATCGGAGTAGAGATTATATGAATGCTAGACGTGTAGCAAAGGAATATGAGACAGTAATGAAAGGCTTGGACCGTAATGCTCCCT
CGGTGCCTCCTCAGAATACTCCTCAAGAAGCTCAACAAGTAGATATGTGGAAGAAATATATACAGTGGGAAAAGAGCAACCCTCTTCGTA
CAGAGGATCAGACCCTTATAACAAAAAGAGTTATGTTTGCTTATGAACAGTGCCTGCTTGTGCTGGGCCATCACCCTGATATTTGGTATG
AAGCTGCCCAGTATCTTGAGCAGTCAAGTAAACTGCTCGCAGAAAAGGGAGATATGAATAATGCCAAATTATTTAGTGATGAAGCTGCTA
ATATATATGAAAGAGCCATAAGCACTTTATTGAAGAAGAATATGCTTCTTTATTTTGCATATGCAGATTATGAAGAGAGTCGCATGAAGT
ATGAAAAGGTTCACAGTATATATAACAGACTTCTGGCAATTGAGGATATTGACCCTACCTTGGTATATATCCAATATATGAAATTTGCAC
GGAGAGCAGAAGGCATCAAATCTGGAAGAATGATATTTAAAAAAGCAAGAGAAGATACCAGAACCCGCCACCATGTCTATGTTACTGCAG
CACTCATGGAATATTACTGTAGTAAGGACAAATCTGTTGCCTTTAAGATTTTTGAGCTGGGGCTAAAAAAATATGGAGACATTCCAGAGT
ATGTCCTGGCCTATATTGACTATCTTTCTCACCTCAATGAGGACAATAATACCCGAGTTTTGTTTGAACGAGTTTTAACATCTGGAAGCC
TTCCTCCTGAGAAGTCTGGAGAAATCTGGGCCCGATTTCTAGCATTTGAAAGTAATATTGGTGATCTAGCTAGTATACTCAAAGTGGAGA
AAAGACGGTTTACAGCATTCAAAGAAGAGTATGAAGGGAAAGAAACGGCTTTACTAGTAGATAGATACAAGTTCATGGATTTATATCCTT
GCTCTGCAAGTGAATTAAAAGCACTTGGTTATAAGGATGTCTCCCGTGCTAAGCTAGCAGCTATAATTCCGGACCCAGTTGTAGCTCCTT
CTATAGTGCCTGTTCTGAAAGATGAAGTGGATAGAAAACCAGAATACCCTAAACCAGACACTCAGCAGATGATTCCATTTCAGCCACGAC
ATTTAGCACCTCCAGGTTTACACCCTGTACCTGGTGGAGTGTTCCCAGTCCCTCCTGCAGCTGTTGTTTTAATGAAACTTCTCCCTCCTC
CTATCTGTTTCCAGGGTCCTTTTGTACAAGTGGATGAACTGATGGAAATTTTCCGAAGATGCAAGATACCAAATACTGTTGAGGAAGCTG
TGAGGATCATTACTGGTGGGGCCCCAGAGCTAGCTGTAGAAGGCAACGGCCCCGTGGAAAGTAATGCAGTACTCACCAAGGCCGTCAAAA
GGCCCAACGAGGATTCAGATGAAGATGAAGAAAAGGGAGCCGTTGTCCCCCCTGTTCATGACATTTACAGAGCACGGCAGCAGAAGCGGA
TTCGGTAGGGTTTTAAACGCCTCTGCAGAAAACTCCTGTCCAGGATTCCTTTTGCCTCAAGTGGTATGTTTAAAAGAGACAACGCTTTGT
TACAAGGTTCTTGGAAACAAAGTTGTATTGTCATTGGTGCCTCTATCACATGGTTCTTGAGAAAAAACAAACCAACCTGTGTGAATTTTA
GAATACGGAACAGACCTATGCTCTAAGCAAAATTAGGTTTTCAAAAATGTGAGAACAGTACAAAGTGGCAGAACCACATTTTGTTCCCTC
TTCAAGGGTGTCTTGTATGTGCCGCTTGAAGATTTGTGAGTTTTTCAACAGTTTTATTTTAAAAACTGGATGGCTTATGATTGTAAAGCA
TTTTATCACATTTTCTGAAAACAATTGTTCTTGGTTTGCTTATGTAGAGTCCTGCCTTATTGTTTGTTTTTATTTATGGCAGAATGTATG

>10440_10440_1_BTBD1-CSTF3_BTBD1_chr15_83725140_ENST00000261721_CSTF3_chr11_33163532_ENST00000323959_length(amino acids)=894AA_BP=185
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLM
KVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINI
EQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEKSNPLRTEDQTLIT
KRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKVHSIY
NRLLAIEDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDTRTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPEYVLAYIDY
LSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLASILKVEKRRFTAFKEEYEGKETALLVDRYKFMDLYPCSASELKA
LGYKDVSRAKLAAIIPDPVVAPSIVPVLKDEVDRKPEYPKPDTQQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVVLMKLLPPPICFQGPF

--------------------------------------------------------------
>10440_10440_2_BTBD1-CSTF3_BTBD1_chr15_83725140_ENST00000261721_CSTF3_chr11_33163532_ENST00000524827_length(transcript)=1196nt_BP=761nt
AGTCCTGTTACACCTCCCGCGGCCGCGCACAGCGGCAACCCGGGCGTGCGGGGGCGCGCGCGGTCAGGGAGGGGCCTGCGGAGGCGCGAG
GCCCCCGGAAGCGCCTTTCCCGGAAGGCAGGGAGGCAGCGCCGGCCTCCGGAGGCGGCCTGGGCGATGGCGGCGGAGTTTTGTCCATAAC
GTGGGCAACCGCGCAGCTGGAGGATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCG
CGGGGCCGCCGCCGCCGCCCTCACCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGG
CGTCGCTGAAGGAGCGCTTCGCCTTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCG
CCGCTGGGGGCCCGCAGCGCATCCCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGG
CCACCACGTCGGCCGAGATCGAGCTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAA
TTGGTCCAGAAACAGTTATGACCACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCA
AACATCTTAGGGCAGATAATGCCTTTATGTTACTTACTCAGGCAGCTGAGTATGTCCCAGAGAAGGTGAAGAAAGCGGAAAAGAAATTAG
AAGAGAATCCATATGACCTTGATGCTTGGAGCATTCTCATTCGAGAGGCACAGAATCAACCTATAGACAAAGCACGGAAGACTTATGAAC
GCCTTGTTGCCCAGTTCCCCAGTTCTGGCAGATTCTGGAAACTGTACATTGAAGCAGAGATTAAAGCTAAAAATTATGACAAGGTTGAAA
AGCTATTTCAGAGATGCCTTATGAAGGTTTTGCACATTGATTTATGGAAGTGTTATCTTTCATATGTCCGAGAAACCAAGGGTAAACTAC
CAAGTTACAAAGAAAAAATGGCTCAAGCATATGACTTTGCACTGGATAAAATTGGAATGGAAATTATGTCCTATCAGATTTGGGTGGATT

>10440_10440_2_BTBD1-CSTF3_BTBD1_chr15_83725140_ENST00000261721_CSTF3_chr11_33163532_ENST00000524827_length(amino acids)=331AA_BP=185
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLM

--------------------------------------------------------------
>10440_10440_3_BTBD1-CSTF3_BTBD1_chr15_83725140_ENST00000379403_CSTF3_chr11_33163532_ENST00000323959_length(transcript)=3188nt_BP=558nt
ATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCGCGGGGCCGCCGCCGCCGCCCTCA
CCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGGCGTCGCTGAAGGAGCGCTTCGCC
TTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCGCCGCTGGGGGCCCGCAGCGCATC
CCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGGCCACCACGTCGGCCGAGATCGAG
CTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAATTGGTCCAGAAACAGTTATGACC
ACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCAAACATCTTAGGGCAGATAATGCC
TTTATGTTACTTACTCAGGCAGCTGAGTATGTCCCAGAGAAGGTGAAGAAAGCGGAAAAGAAATTAGAAGAGAATCCATATGACCTTGAT
GCTTGGAGCATTCTCATTCGAGAGGCACAGAATCAACCTATAGACAAAGCACGGAAGACTTATGAACGCCTTGTTGCCCAGTTCCCCAGT
TCTGGCAGATTCTGGAAACTGTACATTGAAGCAGAGATTAAAGCTAAAAATTATGACAAGGTTGAAAAGCTATTTCAGAGATGCCTTATG
AAGGTTTTGCACATTGATTTATGGAAGTGTTATCTTTCATATGTCCGAGAAACCAAGGGTAAACTACCAAGTTACAAAGAAAAAATGGCT
CAAGCATATGACTTTGCACTGGATAAAATTGGAATGGAAATTATGTCCTATCAGATTTGGGTGGATTACATCAATTTCCTAAAAGGCGTG
GAAGCTGTAGGATCTTATGCAGAAAATCAAAGAATAACAGCTGTCCGAAGAGTTTATCAACGAGGTTGTGTTAATCCGATGATCAACATT
GAACAGCTCTGGAGAGACTATAACAAGTATGAAGAGGGTATCAATATTCATTTAGCTAAAAAAATGATTGAAGATCGGAGTAGAGATTAT
ATGAATGCTAGACGTGTAGCAAAGGAATATGAGACAGTAATGAAAGGCTTGGACCGTAATGCTCCCTCGGTGCCTCCTCAGAATACTCCT
CAAGAAGCTCAACAAGTAGATATGTGGAAGAAATATATACAGTGGGAAAAGAGCAACCCTCTTCGTACAGAGGATCAGACCCTTATAACA
AAAAGAGTTATGTTTGCTTATGAACAGTGCCTGCTTGTGCTGGGCCATCACCCTGATATTTGGTATGAAGCTGCCCAGTATCTTGAGCAG
TCAAGTAAACTGCTCGCAGAAAAGGGAGATATGAATAATGCCAAATTATTTAGTGATGAAGCTGCTAATATATATGAAAGAGCCATAAGC
ACTTTATTGAAGAAGAATATGCTTCTTTATTTTGCATATGCAGATTATGAAGAGAGTCGCATGAAGTATGAAAAGGTTCACAGTATATAT
AACAGACTTCTGGCAATTGAGGATATTGACCCTACCTTGGTATATATCCAATATATGAAATTTGCACGGAGAGCAGAAGGCATCAAATCT
GGAAGAATGATATTTAAAAAAGCAAGAGAAGATACCAGAACCCGCCACCATGTCTATGTTACTGCAGCACTCATGGAATATTACTGTAGT
AAGGACAAATCTGTTGCCTTTAAGATTTTTGAGCTGGGGCTAAAAAAATATGGAGACATTCCAGAGTATGTCCTGGCCTATATTGACTAT
CTTTCTCACCTCAATGAGGACAATAATACCCGAGTTTTGTTTGAACGAGTTTTAACATCTGGAAGCCTTCCTCCTGAGAAGTCTGGAGAA
ATCTGGGCCCGATTTCTAGCATTTGAAAGTAATATTGGTGATCTAGCTAGTATACTCAAAGTGGAGAAAAGACGGTTTACAGCATTCAAA
GAAGAGTATGAAGGGAAAGAAACGGCTTTACTAGTAGATAGATACAAGTTCATGGATTTATATCCTTGCTCTGCAAGTGAATTAAAAGCA
CTTGGTTATAAGGATGTCTCCCGTGCTAAGCTAGCAGCTATAATTCCGGACCCAGTTGTAGCTCCTTCTATAGTGCCTGTTCTGAAAGAT
GAAGTGGATAGAAAACCAGAATACCCTAAACCAGACACTCAGCAGATGATTCCATTTCAGCCACGACATTTAGCACCTCCAGGTTTACAC
CCTGTACCTGGTGGAGTGTTCCCAGTCCCTCCTGCAGCTGTTGTTTTAATGAAACTTCTCCCTCCTCCTATCTGTTTCCAGGGTCCTTTT
GTACAAGTGGATGAACTGATGGAAATTTTCCGAAGATGCAAGATACCAAATACTGTTGAGGAAGCTGTGAGGATCATTACTGGTGGGGCC
CCAGAGCTAGCTGTAGAAGGCAACGGCCCCGTGGAAAGTAATGCAGTACTCACCAAGGCCGTCAAAAGGCCCAACGAGGATTCAGATGAA
GATGAAGAAAAGGGAGCCGTTGTCCCCCCTGTTCATGACATTTACAGAGCACGGCAGCAGAAGCGGATTCGGTAGGGTTTTAAACGCCTC
TGCAGAAAACTCCTGTCCAGGATTCCTTTTGCCTCAAGTGGTATGTTTAAAAGAGACAACGCTTTGTTACAAGGTTCTTGGAAACAAAGT
TGTATTGTCATTGGTGCCTCTATCACATGGTTCTTGAGAAAAAACAAACCAACCTGTGTGAATTTTAGAATACGGAACAGACCTATGCTC
TAAGCAAAATTAGGTTTTCAAAAATGTGAGAACAGTACAAAGTGGCAGAACCACATTTTGTTCCCTCTTCAAGGGTGTCTTGTATGTGCC
GCTTGAAGATTTGTGAGTTTTTCAACAGTTTTATTTTAAAAACTGGATGGCTTATGATTGTAAAGCATTTTATCACATTTTCTGAAAACA
ATTGTTCTTGGTTTGCTTATGTAGAGTCCTGCCTTATTGTTTGTTTTTATTTATGGCAGAATGTATGAAATCCGTTTTGTAGTTTCAAAT

>10440_10440_3_BTBD1-CSTF3_BTBD1_chr15_83725140_ENST00000379403_CSTF3_chr11_33163532_ENST00000323959_length(amino acids)=894AA_BP=185
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLM
KVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINI
EQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEKSNPLRTEDQTLIT
KRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKVHSIY
NRLLAIEDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDTRTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPEYVLAYIDY
LSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLASILKVEKRRFTAFKEEYEGKETALLVDRYKFMDLYPCSASELKA
LGYKDVSRAKLAAIIPDPVVAPSIVPVLKDEVDRKPEYPKPDTQQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVVLMKLLPPPICFQGPF

--------------------------------------------------------------
>10440_10440_4_BTBD1-CSTF3_BTBD1_chr15_83725140_ENST00000379403_CSTF3_chr11_33163532_ENST00000524827_length(transcript)=993nt_BP=558nt
ATGGCCTCACTCGGGCCTGCCGCAGCTGGGGAGCAGGCGTCGGGGGCTGAGGCGGAGCCGGGCCCCGCGGGGCCGCCGCCGCCGCCCTCA
CCGTCCTCTCTGGGGCCCCTGCTCCCCCTGCAGCGGGAACCTCTCTACAACTGGCAGGCGACCAAGGCGTCGCTGAAGGAGCGCTTCGCC
TTCCTCTTCAACTCGGAGCTGCTGAGCGATGTGCGCTTCGTACTGGGCAAGGGTCGCGGCGCCGCCGCCGCTGGGGGCCCGCAGCGCATC
CCCGCCCACCGCTTCGTGCTGGCGGCCGGCAGCGCCGTCTTTGACGCCATGTTCAACGGCGGCATGGCCACCACGTCGGCCGAGATCGAG
CTGCCGGACGTGGAGCCCGCAGCCTTCCTGGCGCTGCTGAGATTTCTATATTCAGATGAAGTTCAAATTGGTCCAGAAACAGTTATGACC
ACTCTTTATACTGCCAAGAAATACGCAGTCCCAGCCTTGGAAGCACACTGTGTAGAATTTCTCACCAAACATCTTAGGGCAGATAATGCC
TTTATGTTACTTACTCAGGCAGCTGAGTATGTCCCAGAGAAGGTGAAGAAAGCGGAAAAGAAATTAGAAGAGAATCCATATGACCTTGAT
GCTTGGAGCATTCTCATTCGAGAGGCACAGAATCAACCTATAGACAAAGCACGGAAGACTTATGAACGCCTTGTTGCCCAGTTCCCCAGT
TCTGGCAGATTCTGGAAACTGTACATTGAAGCAGAGATTAAAGCTAAAAATTATGACAAGGTTGAAAAGCTATTTCAGAGATGCCTTATG
AAGGTTTTGCACATTGATTTATGGAAGTGTTATCTTTCATATGTCCGAGAAACCAAGGGTAAACTACCAAGTTACAAAGAAAAAATGGCT
CAAGCATATGACTTTGCACTGGATAAAATTGGAATGGAAATTATGTCCTATCAGATTTGGGTGGATTACATCAATTTCCTAAAAGGCGTG

>10440_10440_4_BTBD1-CSTF3_BTBD1_chr15_83725140_ENST00000379403_CSTF3_chr11_33163532_ENST00000524827_length(amino acids)=330AA_BP=185
MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRI
PAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
FMLLTQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BTBD1-CSTF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BTBD1-CSTF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BTBD1-CSTF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBTBD1C0520757Delayed Emergence from Anesthesia1CTD_human
HgeneBTBD1C4042763Postoperative Residual Curarization1CTD_human