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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CSNK1G1-MESP1 (FusionGDB2 ID:HG53944TG55897)

Fusion Gene Summary for CSNK1G1-MESP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CSNK1G1-MESP1
Fusion gene ID: hg53944tg55897
HgeneTgene
Gene symbol

CSNK1G1

MESP1

Gene ID

53944

55897

Gene namecasein kinase 1 gamma 1mesoderm posterior bHLH transcription factor 1
SynonymsCK1gamma1bHLHc5
Cytomap('CSNK1G1')('MESP1')

15q22.31

15q26.1

Type of geneprotein-codingprotein-coding
Descriptioncasein kinase I isoform gamma-1mesoderm posterior protein 1class C basic helix-loop-helix protein 5mesoderm posterior 1 homologmesoderm posterior basic helix-loop-helix transcription factor 1
Modification date2020031320200313
UniProtAcc

Q9HCP0

.
Ensembl transtripts involved in fusion geneENST00000303032, ENST00000303052, 
ENST00000607537, 
Fusion gene scores* DoF score14 X 11 X 7=10784 X 2 X 3=24
# samples 156
** MAII scorelog2(15/1078*10)=-2.84532277225662
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/24*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CSNK1G1 [Title/Abstract] AND MESP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCSNK1G1(64592518)-MESP1(90293458), # samples:1
Anticipated loss of major functional domain due to fusion event.CSNK1G1-MESP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CSNK1G1-MESP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCSNK1G1

GO:0018105

peptidyl-serine phosphorylation

25500533

TgeneMESP1

GO:0045944

positive regulation of transcription by RNA polymerase II

18297060


check buttonFusion gene breakpoints across CSNK1G1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MESP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-WE-A8ZM-06ACSNK1G1chr15

64592518

-MESP1chr15

90293458

-


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Fusion Gene ORF analysis for CSNK1G1-MESP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000303032ENST00000559894CSNK1G1chr15

64592518

-MESP1chr15

90293458

-
5CDS-5UTRENST00000303052ENST00000559894CSNK1G1chr15

64592518

-MESP1chr15

90293458

-
5CDS-5UTRENST00000607537ENST00000559894CSNK1G1chr15

64592518

-MESP1chr15

90293458

-
In-frameENST00000303032ENST00000300057CSNK1G1chr15

64592518

-MESP1chr15

90293458

-
In-frameENST00000303052ENST00000300057CSNK1G1chr15

64592518

-MESP1chr15

90293458

-
In-frameENST00000607537ENST00000300057CSNK1G1chr15

64592518

-MESP1chr15

90293458

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000303052CSNK1G1chr1564592518-ENST00000300057MESP1chr1590293458-2172605809339156
ENST00000607537CSNK1G1chr1564592518-ENST00000300057MESP1chr1590293458-2158591795325156
ENST00000303032CSNK1G1chr1564592518-ENST00000300057MESP1chr1590293458-2228661865395156

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000303052ENST00000300057CSNK1G1chr1564592518-MESP1chr1590293458-0.88368540.116314575
ENST00000607537ENST00000300057CSNK1G1chr1564592518-MESP1chr1590293458-0.67702950.3229705
ENST00000303032ENST00000300057CSNK1G1chr1564592518-MESP1chr1590293458-0.75106510.24893495

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Fusion Genomic Features for CSNK1G1-MESP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CSNK1G1-MESP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:64592518/chr15:90293458)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSNK1G1

Q9HCP0

.
FUNCTION: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN. {ECO:0000250, ECO:0000269|PubMed:21680713}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCSNK1G1chr15:64592518chr15:90293458ENST00000303032-21150_5860394.0Nucleotide bindingATP
HgeneCSNK1G1chr15:64592518chr15:90293458ENST00000303052-21250_5860423.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCSNK1G1chr15:64592518chr15:90293458ENST00000303032-21144_31560394.0DomainProtein kinase
HgeneCSNK1G1chr15:64592518chr15:90293458ENST00000303052-21244_31560423.0DomainProtein kinase
TgeneMESP1chr15:64592518chr15:90293458ENST000003000570282_136241269.0DomainbHLH
TgeneMESP1chr15:64592518chr15:90293458ENST0000030005702163_167241269.0MotifNote=CPLCP
TgeneMESP1chr15:64592518chr15:90293458ENST0000030005702182_185241269.0RegionNote=2 X 2 AA tandem repeats of G-Q
TgeneMESP1chr15:64592518chr15:90293458ENST0000030005702182_183241269.0Repeat1
TgeneMESP1chr15:64592518chr15:90293458ENST0000030005702184_185241269.0Repeat2


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Fusion Gene Sequence for CSNK1G1-MESP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19853_19853_1_CSNK1G1-MESP1_CSNK1G1_chr15_64592518_ENST00000303032_MESP1_chr15_90293458_ENST00000300057_length(transcript)=2228nt_BP=661nt
CTGCCCAAAGTTTGTCCTATTAGGCCCGCCAGGGTACTCTGCGACTCCGGGACGAGGGCGGGGCCGCGCTAGTGGTTCCGGTTCGGCTCC
AGCCGCCCCTCGGCTCCTCGCCTTCCCCCTCCCGTCCGCCTTCTCCCCTCCCTCCCGCTCCTGGGAAAGAGAGAAACCACCGCTGCGGGT
GGGTAGAGAAGCACTTGGCGCCTCGGGGAGGGGACCGCGCCCGCCTCATTTGCGCCTTGCAGCACTGCTGGACCAGGTTACAAGATGTTC
ACCTAAGATTGAGACCTAGTGACTACATTTCCTACGGGAACAAATAAATGGTTTTTCATCTCCCGGAGATACATTACAAACAAATATGGT
GCTAAAAGAACTCCTTACCTTTCTCTGACTACAATTTATTTGGACATACTTTTGTATTGAAGAGAGGTATACATACTGAAGCTACTTGCT
GTACTATAGGAGACTCTGTCCTGTAGGATCATGGACCATCCTAGTAGGGAAAAGGATGAAAGACAACGGACAACTAAACCCATGGCACAA
AGGAGTGCACACTGCTCTCGACCATCTGGCTCCTCATCGTCCTCTGGGGTTCTTATGGTGGGACCCAACTTCAGGGTTGGCAAGAAGATA
GGATGTGGGAACTTCGGAGAGCTCAGATTAGCTCCTTCCGGGCGACGTGCTGGCTCTGTTGGAGACCTGGATGCCCCTCTCGCCTCTGGA
GTGGCTGCCTGAGGAGCCCAAGTGACAAGGGACAACTGACGCCGTCTCTGTGAGCACCGAGGCTTTTTGGCCTCAGCACCTTCGAAGTGG
TTCCTTGGCAGACTGCCTTTCCTGGAAGAGGGCACGGGCGATCCCGACGGGGGCATTCCTGCGGGTGAGAGCCGTCCCCACCGCGGCGGC
CCTTCTCAGCCCCTCCCTCCATGGAGGGACCCATAGGGCTAGACACTTTGAGGCAAGCAGGAGGCTCTGCCTAATGTGAATTTATTTATT
TGTGAATAAACTGTACTGGTGTCAGTTGGCAATTTCTTCTTCCTACCCGTGGACACAGAGCTCCCTCTCTCCCTCCAAAGAAGAGCATGG
GAGAGGTGGGAGGGGTTCTTGCAATCTTTAGCCCCCCGACCCCCACAGGCCCAGACCCCTTTGGCCTTACCCCCAGCCCTGGCTCAGCAT
CTAGTCCAGATGGGTCAGCCTGGAATGGGTGGGGAGGGACGTCCTGTGAGAAGGCAGCGGCAAGTAGAATCTGCTCATCTTTTCTTTGAA
CCTGGTGGGGAACTGGTTAAAACCAAAATATCTGTGTAGAAATACAACTCCATTATTGAGTATTTATTGTATGTACATCAGGTACCTATT
ATACTCAAGTAACCATTTTACAGAAGGATGAGGATCAGCGCTCAAGCCCAGGTAGGCCTCCAGAGTCCCAGCGCTCAGCTCTTGTGGGAT
TTTGCCAGCTCCATACATGTTGGGGCCTGAGGGATAACAGCTCCAAGGGGTTATTTTCTTGCATCCTGTGGTCTTATTCTCCATGCACGG
GAGCATCCTGGCCTTGGAACTCCCCCACCCTCCGCCGGCATTTTCCCATCTGCCTTTTCTCTGGTTTCCCCACCTTGTGGCTTAGAGACA
TAAATAATGGTGTGGCGGTCCTGAGTTTATATAACCATGACCTCCTACAGGCCTAGATGGGGTGAGATGAGGGGCCCATGGGGTTGCATC
GGAATCCACACAGGCAGTTGCGTGCCTGTCTGCATTGGCTGGATTCACATCAGGGAGCAAGAAACGGGAGGCTTGAGCCCAGAAAGTGTG
TCCTCATCCAGCCAGGGTGTCTGGGCAACAGTCATGATTAGAGGGTGCGGTGGGGAGAAGGGATGTGTAGCCTCTCTGCCAAGCGTCCTT
TACCCTCTATGGATAGATACCCAGTTCTCCCCTCCTCTCCTTCAAGTGTCTGAAACACAGGCTTCAGTGTCTGTTTTTATAAGAGCTTTA
TTAGGATACAATTCACATACCATAAAATTCACTCTTTTAACAACTGAATGGCTTTAGTACATCCACAGAGTTGTGCAAGCATTGCCACTA
ATTTTAGAACGTTTTCACCCCCCAAAAGAAACCGTATACCTGTTAACATCACTCCTCACTATTCCCTACTCCCAGTCCCTGGCACTCACT

>19853_19853_1_CSNK1G1-MESP1_CSNK1G1_chr15_64592518_ENST00000303032_MESP1_chr15_90293458_ENST00000300057_length(amino acids)=156AA_BP=0
MPPSGSPVPSSRKGSLPRNHFEGAEAKKPRCSQRRRQLSLVTWAPQAATPEARGASRSPTEPARRPEGANLSSPKFPHPIFLPTLKLGPT

--------------------------------------------------------------
>19853_19853_2_CSNK1G1-MESP1_CSNK1G1_chr15_64592518_ENST00000303052_MESP1_chr15_90293458_ENST00000300057_length(transcript)=2172nt_BP=605nt
GGCGGGGCCGCGCTAGTGGTTCCGGTTCGGCTCCAGCCGCCCCTCGGCTCCTCGCCTTCCCCCTCCCGTCCGCCTTCTCCCCTCCCTCCC
GCTCCTGGGAAAGAGAGAAACCACCGCTGCGGGTGGGTAGAGAAGCACTTGGCGCCTCGGGGAGGGGACCGCGCCCGCCTCATTTGCGCC
TTGCAGCACTGCTGGACCAGGTTACAAGATGTTCACCTAAGATTGAGACCTAGTGACTACATTTCCTACGGGAACAAATAAATGGTTTTT
CATCTCCCGGAGATACATTACAAACAAATATGGTGCTAAAAGAACTCCTTACCTTTCTCTGACTACAATTTATTTGGACATACTTTTGTA
TTGAAGAGAGGTATACATACTGAAGCTACTTGCTGTACTATAGGAGACTCTGTCCTGTAGGATCATGGACCATCCTAGTAGGGAAAAGGA
TGAAAGACAACGGACAACTAAACCCATGGCACAAAGGAGTGCACACTGCTCTCGACCATCTGGCTCCTCATCGTCCTCTGGGGTTCTTAT
GGTGGGACCCAACTTCAGGGTTGGCAAGAAGATAGGATGTGGGAACTTCGGAGAGCTCAGATTAGCTCCTTCCGGGCGACGTGCTGGCTC
TGTTGGAGACCTGGATGCCCCTCTCGCCTCTGGAGTGGCTGCCTGAGGAGCCCAAGTGACAAGGGACAACTGACGCCGTCTCTGTGAGCA
CCGAGGCTTTTTGGCCTCAGCACCTTCGAAGTGGTTCCTTGGCAGACTGCCTTTCCTGGAAGAGGGCACGGGCGATCCCGACGGGGGCAT
TCCTGCGGGTGAGAGCCGTCCCCACCGCGGCGGCCCTTCTCAGCCCCTCCCTCCATGGAGGGACCCATAGGGCTAGACACTTTGAGGCAA
GCAGGAGGCTCTGCCTAATGTGAATTTATTTATTTGTGAATAAACTGTACTGGTGTCAGTTGGCAATTTCTTCTTCCTACCCGTGGACAC
AGAGCTCCCTCTCTCCCTCCAAAGAAGAGCATGGGAGAGGTGGGAGGGGTTCTTGCAATCTTTAGCCCCCCGACCCCCACAGGCCCAGAC
CCCTTTGGCCTTACCCCCAGCCCTGGCTCAGCATCTAGTCCAGATGGGTCAGCCTGGAATGGGTGGGGAGGGACGTCCTGTGAGAAGGCA
GCGGCAAGTAGAATCTGCTCATCTTTTCTTTGAACCTGGTGGGGAACTGGTTAAAACCAAAATATCTGTGTAGAAATACAACTCCATTAT
TGAGTATTTATTGTATGTACATCAGGTACCTATTATACTCAAGTAACCATTTTACAGAAGGATGAGGATCAGCGCTCAAGCCCAGGTAGG
CCTCCAGAGTCCCAGCGCTCAGCTCTTGTGGGATTTTGCCAGCTCCATACATGTTGGGGCCTGAGGGATAACAGCTCCAAGGGGTTATTT
TCTTGCATCCTGTGGTCTTATTCTCCATGCACGGGAGCATCCTGGCCTTGGAACTCCCCCACCCTCCGCCGGCATTTTCCCATCTGCCTT
TTCTCTGGTTTCCCCACCTTGTGGCTTAGAGACATAAATAATGGTGTGGCGGTCCTGAGTTTATATAACCATGACCTCCTACAGGCCTAG
ATGGGGTGAGATGAGGGGCCCATGGGGTTGCATCGGAATCCACACAGGCAGTTGCGTGCCTGTCTGCATTGGCTGGATTCACATCAGGGA
GCAAGAAACGGGAGGCTTGAGCCCAGAAAGTGTGTCCTCATCCAGCCAGGGTGTCTGGGCAACAGTCATGATTAGAGGGTGCGGTGGGGA
GAAGGGATGTGTAGCCTCTCTGCCAAGCGTCCTTTACCCTCTATGGATAGATACCCAGTTCTCCCCTCCTCTCCTTCAAGTGTCTGAAAC
ACAGGCTTCAGTGTCTGTTTTTATAAGAGCTTTATTAGGATACAATTCACATACCATAAAATTCACTCTTTTAACAACTGAATGGCTTTA
GTACATCCACAGAGTTGTGCAAGCATTGCCACTAATTTTAGAACGTTTTCACCCCCCAAAAGAAACCGTATACCTGTTAACATCACTCCT
CACTATTCCCTACTCCCAGTCCCTGGCACTCACTCTTCTAGTCTCTGTCTCTATAGGTTTGCTTTTTCAGGACATTTCATATAAAAGGAA

>19853_19853_2_CSNK1G1-MESP1_CSNK1G1_chr15_64592518_ENST00000303052_MESP1_chr15_90293458_ENST00000300057_length(amino acids)=156AA_BP=0
MPPSGSPVPSSRKGSLPRNHFEGAEAKKPRCSQRRRQLSLVTWAPQAATPEARGASRSPTEPARRPEGANLSSPKFPHPIFLPTLKLGPT

--------------------------------------------------------------
>19853_19853_3_CSNK1G1-MESP1_CSNK1G1_chr15_64592518_ENST00000607537_MESP1_chr15_90293458_ENST00000300057_length(transcript)=2158nt_BP=591nt
AGTGGTTCCGGTTCGGCTCCAGCCGCCCCTCGGCTCCTCGCCTTCCCCCTCCCGTCCGCCTTCTCCCCTCCCTCCCGCTCCTGGGAAAGA
GAGAAACCACCGCTGCGGGTGGGTAGAGAAGCACTTGGCGCCTCGGGGAGGGGACCGCGCCCGCCTCATTTGCGCCTTGCAGCACTGCTG
GACCAGGTTACAAGATGTTCACCTAAGATTGAGACCTAGTGACTACATTTCCTACGGGAACAAATAAATGGTTTTTCATCTCCCGGAGAT
ACATTACAAACAAATATGGTGCTAAAAGAACTCCTTACCTTTCTCTGACTACAATTTATTTGGACATACTTTTGTATTGAAGAGAGGTAT
ACATACTGAAGCTACTTGCTGTACTATAGGAGACTCTGTCCTGTAGGATCATGGACCATCCTAGTAGGGAAAAGGATGAAAGACAACGGA
CAACTAAACCCATGGCACAAAGGAGTGCACACTGCTCTCGACCATCTGGCTCCTCATCGTCCTCTGGGGTTCTTATGGTGGGACCCAACT
TCAGGGTTGGCAAGAAGATAGGATGTGGGAACTTCGGAGAGCTCAGATTAGCTCCTTCCGGGCGACGTGCTGGCTCTGTTGGAGACCTGG
ATGCCCCTCTCGCCTCTGGAGTGGCTGCCTGAGGAGCCCAAGTGACAAGGGACAACTGACGCCGTCTCTGTGAGCACCGAGGCTTTTTGG
CCTCAGCACCTTCGAAGTGGTTCCTTGGCAGACTGCCTTTCCTGGAAGAGGGCACGGGCGATCCCGACGGGGGCATTCCTGCGGGTGAGA
GCCGTCCCCACCGCGGCGGCCCTTCTCAGCCCCTCCCTCCATGGAGGGACCCATAGGGCTAGACACTTTGAGGCAAGCAGGAGGCTCTGC
CTAATGTGAATTTATTTATTTGTGAATAAACTGTACTGGTGTCAGTTGGCAATTTCTTCTTCCTACCCGTGGACACAGAGCTCCCTCTCT
CCCTCCAAAGAAGAGCATGGGAGAGGTGGGAGGGGTTCTTGCAATCTTTAGCCCCCCGACCCCCACAGGCCCAGACCCCTTTGGCCTTAC
CCCCAGCCCTGGCTCAGCATCTAGTCCAGATGGGTCAGCCTGGAATGGGTGGGGAGGGACGTCCTGTGAGAAGGCAGCGGCAAGTAGAAT
CTGCTCATCTTTTCTTTGAACCTGGTGGGGAACTGGTTAAAACCAAAATATCTGTGTAGAAATACAACTCCATTATTGAGTATTTATTGT
ATGTACATCAGGTACCTATTATACTCAAGTAACCATTTTACAGAAGGATGAGGATCAGCGCTCAAGCCCAGGTAGGCCTCCAGAGTCCCA
GCGCTCAGCTCTTGTGGGATTTTGCCAGCTCCATACATGTTGGGGCCTGAGGGATAACAGCTCCAAGGGGTTATTTTCTTGCATCCTGTG
GTCTTATTCTCCATGCACGGGAGCATCCTGGCCTTGGAACTCCCCCACCCTCCGCCGGCATTTTCCCATCTGCCTTTTCTCTGGTTTCCC
CACCTTGTGGCTTAGAGACATAAATAATGGTGTGGCGGTCCTGAGTTTATATAACCATGACCTCCTACAGGCCTAGATGGGGTGAGATGA
GGGGCCCATGGGGTTGCATCGGAATCCACACAGGCAGTTGCGTGCCTGTCTGCATTGGCTGGATTCACATCAGGGAGCAAGAAACGGGAG
GCTTGAGCCCAGAAAGTGTGTCCTCATCCAGCCAGGGTGTCTGGGCAACAGTCATGATTAGAGGGTGCGGTGGGGAGAAGGGATGTGTAG
CCTCTCTGCCAAGCGTCCTTTACCCTCTATGGATAGATACCCAGTTCTCCCCTCCTCTCCTTCAAGTGTCTGAAACACAGGCTTCAGTGT
CTGTTTTTATAAGAGCTTTATTAGGATACAATTCACATACCATAAAATTCACTCTTTTAACAACTGAATGGCTTTAGTACATCCACAGAG
TTGTGCAAGCATTGCCACTAATTTTAGAACGTTTTCACCCCCCAAAAGAAACCGTATACCTGTTAACATCACTCCTCACTATTCCCTACT

>19853_19853_3_CSNK1G1-MESP1_CSNK1G1_chr15_64592518_ENST00000607537_MESP1_chr15_90293458_ENST00000300057_length(amino acids)=156AA_BP=0
MPPSGSPVPSSRKGSLPRNHFEGAEAKKPRCSQRRRQLSLVTWAPQAATPEARGASRSPTEPARRPEGANLSSPKFPHPIFLPTLKLGPT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CSNK1G1-MESP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CSNK1G1-MESP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CSNK1G1-MESP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource