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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ACP2-CD74 (FusionGDB2 ID:HG53TG972) |
Fusion Gene Summary for ACP2-CD74 |
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Fusion gene information | Fusion gene name: ACP2-CD74 | Fusion gene ID: hg53tg972 | Hgene | Tgene | Gene symbol | ACP2 | CD74 | Gene ID | 53 | 972 |
Gene name | acid phosphatase 2, lysosomal | CD74 molecule | |
Synonyms | LAP | DHLAG|HLADG|II|Ia-GAMMA|p33 | |
Cytomap | ('ACP2')('CD74') 11p11.2|11p12-p11 | 5q33.1 | |
Type of gene | protein-coding | protein-coding | |
Description | lysosomal acid phosphatase | HLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P11117 | P04233 | |
Ensembl transtripts involved in fusion gene | ENST00000529444, ENST00000256997, ENST00000444355, ENST00000525230, ENST00000527256, ENST00000529788, ENST00000530453, ENST00000533929, ENST00000537863, | ||
Fusion gene scores | * DoF score | 5 X 6 X 4=120 | 31 X 31 X 11=10571 |
# samples | 5 | 39 | |
** MAII score | log2(5/120*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(39/10571*10)=-4.76049392566144 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACP2 [Title/Abstract] AND CD74 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ACP2(47261044)-CD74(149792295), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | ACP2-CD74 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ACP2-CD74 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ACP2-CD74 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. ACP2-CD74 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CD74 | GO:0001516 | prostaglandin biosynthetic process | 12782713 |
Tgene | CD74 | GO:0001934 | positive regulation of protein phosphorylation | 24942581 |
Tgene | CD74 | GO:0002792 | negative regulation of peptide secretion | 19849849 |
Tgene | CD74 | GO:0033674 | positive regulation of kinase activity | 24942581 |
Tgene | CD74 | GO:0043066 | negative regulation of apoptotic process | 12782713 |
Tgene | CD74 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 24942581 |
Tgene | CD74 | GO:0043410 | positive regulation of MAPK cascade | 24942581 |
Tgene | CD74 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 17045821 |
Tgene | CD74 | GO:0045657 | positive regulation of monocyte differentiation | 24942581 |
Tgene | CD74 | GO:0045893 | positive regulation of transcription, DNA-templated | 24942581 |
Tgene | CD74 | GO:0046598 | positive regulation of viral entry into host cell | 24942581 |
Tgene | CD74 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 17045821 |
Tgene | CD74 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 17045821|24942581 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | CESC | TCGA-IR-A3LH-01A | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
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Fusion Gene ORF analysis for ACP2-CD74 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000529444 | ENST00000009530 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
Frame-shift | ENST00000529444 | ENST00000353334 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
Frame-shift | ENST00000529444 | ENST00000377795 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
Frame-shift | ENST00000529444 | ENST00000524315 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000256997 | ENST00000009530 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000256997 | ENST00000353334 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000256997 | ENST00000377795 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000256997 | ENST00000524315 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000444355 | ENST00000009530 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000444355 | ENST00000353334 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000444355 | ENST00000377795 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000444355 | ENST00000524315 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000525230 | ENST00000009530 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000525230 | ENST00000353334 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000525230 | ENST00000377795 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000525230 | ENST00000524315 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000527256 | ENST00000009530 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000527256 | ENST00000353334 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000527256 | ENST00000377795 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000527256 | ENST00000524315 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000529788 | ENST00000009530 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000529788 | ENST00000353334 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000529788 | ENST00000377795 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000529788 | ENST00000524315 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000530453 | ENST00000009530 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000530453 | ENST00000353334 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000530453 | ENST00000377795 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000530453 | ENST00000524315 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000533929 | ENST00000009530 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000533929 | ENST00000353334 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000533929 | ENST00000377795 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000533929 | ENST00000524315 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000537863 | ENST00000009530 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000537863 | ENST00000353334 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000537863 | ENST00000377795 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
intron-3CDS | ENST00000537863 | ENST00000524315 | ACP2 | chr11 | 47261044 | - | CD74 | chr5 | 149792295 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ACP2-CD74 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ACP2-CD74 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:47261044/:149792295) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ACP2 | CD74 |
FUNCTION: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.; FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. {ECO:0000269|PubMed:1448172}.; FUNCTION: [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed:32855215). {ECO:0000250|UniProtKB:P04441, ECO:0000269|PubMed:32855215}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ACP2-CD74 |
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Fusion Gene PPI Analysis for ACP2-CD74 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ACP2-CD74 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ACP2-CD74 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human | |
Tgene | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human | |
Tgene | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human | |
Tgene | C0162557 | Liver Failure, Acute | 1 | CTD_human | |
Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |