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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRWD1-DSCAM (FusionGDB2 ID:HG54014TG1826)

Fusion Gene Summary for BRWD1-DSCAM

check button Fusion gene summary
Fusion gene informationFusion gene name: BRWD1-DSCAM
Fusion gene ID: hg54014tg1826
HgeneTgene
Gene symbol

BRWD1

DSCAM

Gene ID

54014

1826

Gene namebromodomain and WD repeat domain containing 1DS cell adhesion molecule
SynonymsC21orf107|DCAF19|N143|WDR9|WRD9CHD2|CHD2-42|CHD2-52
Cytomap('BRWD1')('DSCAM')

21q22.2

21q22.2

Type of geneprotein-codingprotein-coding
Descriptionbromodomain and WD repeat-containing protein 1WD repeat protein WDR9-form2WD repeat-containing protein 9transcriptional unit N143Down syndrome cell adhesion molecule
Modification date2020031320200313
UniProtAcc.

O60469

Ensembl transtripts involved in fusion geneENST00000333229, ENST00000342449, 
ENST00000380800, ENST00000341322, 
ENST00000470108, 
Fusion gene scores* DoF score28 X 28 X 10=784013 X 11 X 6=858
# samples 3215
** MAII scorelog2(32/7840*10)=-4.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/858*10)=-2.51601514700366
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRWD1 [Title/Abstract] AND DSCAM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRWD1(40641825)-DSCAM(41385313), # samples:2
Anticipated loss of major functional domain due to fusion event.BRWD1-DSCAM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRWD1-DSCAM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDSCAM

GO:0042327

positive regulation of phosphorylation

19196994

TgeneDSCAM

GO:0048842

positive regulation of axon extension involved in axon guidance

18585357


check buttonFusion gene breakpoints across BRWD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DSCAM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A1LG-01ABRWD1chr21

40636385

-DSCAMchr21

41607576

+
ChimerDB4OVTCGA-24-2289-01ABRWD1chr21

40641825

-DSCAMchr21

41385313

-
ChimerDB4OVTCGA-24-2289BRWD1chr21

40641824

-DSCAMchr21

41385313

-


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Fusion Gene ORF analysis for BRWD1-DSCAM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000333229ENST00000400454BRWD1chr21

40636385

-DSCAMchr21

41607576

+
5CDS-intronENST00000342449ENST00000400454BRWD1chr21

40636385

-DSCAMchr21

41607576

+
5CDS-intronENST00000380800ENST00000400454BRWD1chr21

40636385

-DSCAMchr21

41607576

+
In-frameENST00000333229ENST00000400454BRWD1chr21

40641825

-DSCAMchr21

41385313

-
In-frameENST00000333229ENST00000400454BRWD1chr21

40641824

-DSCAMchr21

41385313

-
In-frameENST00000342449ENST00000400454BRWD1chr21

40641825

-DSCAMchr21

41385313

-
In-frameENST00000342449ENST00000400454BRWD1chr21

40641824

-DSCAMchr21

41385313

-
In-frameENST00000380800ENST00000400454BRWD1chr21

40641825

-DSCAMchr21

41385313

-
In-frameENST00000380800ENST00000400454BRWD1chr21

40641824

-DSCAMchr21

41385313

-
intron-3CDSENST00000341322ENST00000400454BRWD1chr21

40641825

-DSCAMchr21

41385313

-
intron-3CDSENST00000341322ENST00000400454BRWD1chr21

40641824

-DSCAMchr21

41385313

-
intron-3CDSENST00000470108ENST00000400454BRWD1chr21

40641825

-DSCAMchr21

41385313

-
intron-3CDSENST00000470108ENST00000400454BRWD1chr21

40641824

-DSCAMchr21

41385313

-
intron-intronENST00000341322ENST00000400454BRWD1chr21

40636385

-DSCAMchr21

41607576

+
intron-intronENST00000470108ENST00000400454BRWD1chr21

40636385

-DSCAMchr21

41607576

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000333229BRWD1chr2140641825-ENST00000400454DSCAMchr2141385313-424618582351905556
ENST00000342449BRWD1chr2140641825-ENST00000400454DSCAMchr2141385313-39971609791656525
ENST00000380800BRWD1chr2140641825-ENST00000400454DSCAMchr2141385313-4017162961676556
ENST00000333229BRWD1chr2140641824-ENST00000400454DSCAMchr2141385313-424618582351905556
ENST00000342449BRWD1chr2140641824-ENST00000400454DSCAMchr2141385313-39971609791656525
ENST00000380800BRWD1chr2140641824-ENST00000400454DSCAMchr2141385313-4017162961676556

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000333229ENST00000400454BRWD1chr2140641825-DSCAMchr2141385313-0.0083493650.99165064
ENST00000342449ENST00000400454BRWD1chr2140641825-DSCAMchr2141385313-0.0076808410.99231917
ENST00000380800ENST00000400454BRWD1chr2140641825-DSCAMchr2141385313-0.0076418450.99235815
ENST00000333229ENST00000400454BRWD1chr2140641824-DSCAMchr2141385313-0.0083493650.99165064
ENST00000342449ENST00000400454BRWD1chr2140641824-DSCAMchr2141385313-0.0076808410.99231917
ENST00000380800ENST00000400454BRWD1chr2140641824-DSCAMchr2141385313-0.0076418450.99235815

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Fusion Genomic Features for BRWD1-DSCAM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BRWD1-DSCAM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:40641825/chr21:41385313)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DSCAM

O60469

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (By similarity). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). {ECO:0000250|UniProtKB:F1NY98, ECO:0000250|UniProtKB:Q9ERC8, ECO:0000269|PubMed:10925149, ECO:0000269|PubMed:15169762, ECO:0000269|PubMed:18585357, ECO:0000269|PubMed:19196994}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542184_2235102321.0RepeatNote=WD 1
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542226_2655102321.0RepeatNote=WD 2
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542268_3115102321.0RepeatNote=WD 3
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542322_3655102321.0RepeatNote=WD 4
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542366_4055102321.0RepeatNote=WD 5
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542424_4635102321.0RepeatNote=WD 6
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542466_5065102321.0RepeatNote=WD 7
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541184_2235102270.0RepeatNote=WD 1
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541226_2655102270.0RepeatNote=WD 2
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541268_3115102270.0RepeatNote=WD 3
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541322_3655102270.0RepeatNote=WD 4
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541366_4055102270.0RepeatNote=WD 5
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541424_4635102270.0RepeatNote=WD 6
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541466_5065102270.0RepeatNote=WD 7
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542184_2235102200.0RepeatNote=WD 1
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542226_2655102200.0RepeatNote=WD 2
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542268_3115102200.0RepeatNote=WD 3
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542322_3655102200.0RepeatNote=WD 4
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542366_4055102200.0RepeatNote=WD 5
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542424_4635102200.0RepeatNote=WD 6
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542466_5065102200.0RepeatNote=WD 7
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542184_2235102321.0RepeatNote=WD 1
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542226_2655102321.0RepeatNote=WD 2
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542268_3115102321.0RepeatNote=WD 3
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542322_3655102321.0RepeatNote=WD 4
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542366_4055102321.0RepeatNote=WD 5
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542424_4635102321.0RepeatNote=WD 6
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542466_5065102321.0RepeatNote=WD 7
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541184_2235102270.0RepeatNote=WD 1
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541226_2655102270.0RepeatNote=WD 2
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541268_3115102270.0RepeatNote=WD 3
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541322_3655102270.0RepeatNote=WD 4
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541366_4055102270.0RepeatNote=WD 5
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541424_4635102270.0RepeatNote=WD 6
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541466_5065102270.0RepeatNote=WD 7
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542184_2235102200.0RepeatNote=WD 1
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542226_2655102200.0RepeatNote=WD 2
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542268_3115102200.0RepeatNote=WD 3
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542322_3655102200.0RepeatNote=WD 4
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542366_4055102200.0RepeatNote=WD 5
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542424_4635102200.0RepeatNote=WD 6
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542466_5065102200.0RepeatNote=WD 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-15421539_15485102321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-15421687_16925102321.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542661_6685102321.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542821_8245102321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-151539_15480121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-151687_16920121.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15661_6680121.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15821_8240121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-15411539_15485102270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-15411687_16925102270.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541661_6685102270.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541821_8245102270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-15421539_15485102200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-15421687_16925102200.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542661_6685102200.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542821_8245102200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-15421539_15485102321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-15421687_16925102321.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542661_6685102321.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542821_8245102321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-151539_15480121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-151687_16920121.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15661_6680121.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15821_8240121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-15411539_15485102270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-15411687_16925102270.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541661_6685102270.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541821_8245102270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-15421539_15485102200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-15421687_16925102200.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542661_6685102200.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542821_8245102200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-15421177_12475102321.0DomainBromo 1
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-15421330_14005102321.0DomainBromo 2
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-151177_12470121.0DomainBromo 1
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-151330_14000121.0DomainBromo 2
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-15411177_12475102270.0DomainBromo 1
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-15411330_14005102270.0DomainBromo 2
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-15421177_12475102200.0DomainBromo 1
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-15421330_14005102200.0DomainBromo 2
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-15421177_12475102321.0DomainBromo 1
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-15421330_14005102321.0DomainBromo 2
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-151177_12470121.0DomainBromo 1
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-151330_14000121.0DomainBromo 2
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-15411177_12475102270.0DomainBromo 1
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-15411330_14005102270.0DomainBromo 2
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-15421177_12475102200.0DomainBromo 1
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-15421330_14005102200.0DomainBromo 2
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542514_5535102321.0RepeatNote=WD 8
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15184_2230121.0RepeatNote=WD 1
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15226_2650121.0RepeatNote=WD 2
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15268_3110121.0RepeatNote=WD 3
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15322_3650121.0RepeatNote=WD 4
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15366_4050121.0RepeatNote=WD 5
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15424_4630121.0RepeatNote=WD 6
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15466_5060121.0RepeatNote=WD 7
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15514_5530121.0RepeatNote=WD 8
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541514_5535102270.0RepeatNote=WD 8
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542514_5535102200.0RepeatNote=WD 8
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542514_5535102321.0RepeatNote=WD 8
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15184_2230121.0RepeatNote=WD 1
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15226_2650121.0RepeatNote=WD 2
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15268_3110121.0RepeatNote=WD 3
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15322_3650121.0RepeatNote=WD 4
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15366_4050121.0RepeatNote=WD 5
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15424_4630121.0RepeatNote=WD 6
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15466_5060121.0RepeatNote=WD 7
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15514_5530121.0RepeatNote=WD 8
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541514_5535102270.0RepeatNote=WD 8
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542514_5535102200.0RepeatNote=WD 8
TgeneDSCAMchr21:40641824chr21:41385313ENST0000040045431331091_118718952013.0DomainFibronectin type-III 3
TgeneDSCAMchr21:40641824chr21:41385313ENST0000040045431331191_128518952013.0DomainFibronectin type-III 4
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133125_21618952013.0DomainNote=Ig-like C2-type 2
TgeneDSCAMchr21:40641824chr21:41385313ENST0000040045431331285_137718952013.0DomainNote=Ig-like C2-type 10
TgeneDSCAMchr21:40641824chr21:41385313ENST0000040045431331379_147318952013.0DomainFibronectin type-III 5
TgeneDSCAMchr21:40641824chr21:41385313ENST0000040045431331474_157518952013.0DomainFibronectin type-III 6
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133225_30518952013.0DomainNote=Ig-like C2-type 3
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133313_40118952013.0DomainNote=Ig-like C2-type 4
TgeneDSCAMchr21:40641824chr21:41385313ENST00000400454313339_12918952013.0DomainNote=Ig-like C2-type 1
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133407_50018952013.0DomainNote=Ig-like C2-type 5
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133504_59218952013.0DomainNote=Ig-like C2-type 6
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133596_68518952013.0DomainNote=Ig-like C2-type 7
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133690_78318952013.0DomainNote=Ig-like C2-type 8
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133787_88318952013.0DomainNote=Ig-like C2-type 9
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133885_98218952013.0DomainFibronectin type-III 1
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133987_108618952013.0DomainFibronectin type-III 2
TgeneDSCAMchr21:40641825chr21:41385313ENST0000040045431331091_118718952013.0DomainFibronectin type-III 3
TgeneDSCAMchr21:40641825chr21:41385313ENST0000040045431331191_128518952013.0DomainFibronectin type-III 4
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133125_21618952013.0DomainNote=Ig-like C2-type 2
TgeneDSCAMchr21:40641825chr21:41385313ENST0000040045431331285_137718952013.0DomainNote=Ig-like C2-type 10
TgeneDSCAMchr21:40641825chr21:41385313ENST0000040045431331379_147318952013.0DomainFibronectin type-III 5
TgeneDSCAMchr21:40641825chr21:41385313ENST0000040045431331474_157518952013.0DomainFibronectin type-III 6
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133225_30518952013.0DomainNote=Ig-like C2-type 3
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133313_40118952013.0DomainNote=Ig-like C2-type 4
TgeneDSCAMchr21:40641825chr21:41385313ENST00000400454313339_12918952013.0DomainNote=Ig-like C2-type 1
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133407_50018952013.0DomainNote=Ig-like C2-type 5
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133504_59218952013.0DomainNote=Ig-like C2-type 6
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133596_68518952013.0DomainNote=Ig-like C2-type 7
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133690_78318952013.0DomainNote=Ig-like C2-type 8
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133787_88318952013.0DomainNote=Ig-like C2-type 9
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133885_98218952013.0DomainFibronectin type-III 1
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133987_108618952013.0DomainFibronectin type-III 2
TgeneDSCAMchr21:40641824chr21:41385313ENST0000040045431331617_201218952013.0RegionRequired for netrin-mediated axon repulsion of neuronal growth cones
TgeneDSCAMchr21:40641825chr21:41385313ENST0000040045431331617_201218952013.0RegionRequired for netrin-mediated axon repulsion of neuronal growth cones
TgeneDSCAMchr21:40641824chr21:41385313ENST00000400454313318_159518952013.0Topological domainExtracellular
TgeneDSCAMchr21:40641825chr21:41385313ENST00000400454313318_159518952013.0Topological domainExtracellular
TgeneDSCAMchr21:40641824chr21:41385313ENST0000040045431331596_161618952013.0TransmembraneHelical
TgeneDSCAMchr21:40641825chr21:41385313ENST0000040045431331596_161618952013.0TransmembraneHelical


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Fusion Gene Sequence for BRWD1-DSCAM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10342_10342_1_BRWD1-DSCAM_BRWD1_chr21_40641824_ENST00000333229_DSCAM_chr21_41385313_ENST00000400454_length(transcript)=4246nt_BP=1858nt
AGGTCTTTGCCTCCGCGTCACTTTCTCCTCATCGAGTCCCCGGAGGCAGAGAGCTGAGCGAGGTTCGCCTCCCCGGGCGGGACACGAGCT
CCGGTCCTCTCTTGGCGCAAACCCCCGCCCCCCGCGGAGGGACTACTTTTCGTCTCCCGCGGAGGAACTACTTCCTCCCCCGCGGAGGCG
TCGGTCCAGGCGGCGCGCACGGTATGGCGGCGGCGGCGGCGGCGGCGGCGCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCG
GCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCGCGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGT
GCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCGGCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGA
GCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAACGAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAA
GCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCTATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCAC
TTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGACTGCAGGCACACAGTTTGGAAGGGCTCTGCCTTTGCTGCTCT
TCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCAAATCTTGTGGAGATACATCGAGGAAAACAACTCACAGGGTG
TTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAAATGCACAGAAGGATTCTCGGACATCTATCTGCTGTTTACTG
TGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGACTGTTTGGTAAAGATTTGGTCAACACATAATGGCCGCTTGTT
ATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAACTATGAGAATACAATGATTGCTGCGGGGAGCTGTGATAAAAT
TATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAAGGACACACAGGATCAATTACATCTTTACAGTTTAGCCCGAT
GGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACAGTTTGCTTTTGGCAATGGGATTTAGAATCCTTAAAATTTAG
CCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATGCTTTGTTCTTCTTTTAGTGTTGGTGGTATGTTTTTAGCCAC
AGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCACCCGAAAAAATCGCAGAACTTGAAAGCCACACTGATAAAGT
AGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGCAGAGATGGAACAGCACGGATTTGGAGATTTGAGCAGTTAGA
ATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTATCTTCCGAAGAGGAAAGGTTTATGAAACCTAAAGTAACAAT
GATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGATCATGTCCTCAAAGTGTGGAATTCTTACACTGGACAACTGCT
TCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACATCCCTTTGATTCCAGAATTATGTTATCTGCAGGACATGATGG
CAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTATTTTAATATGGTGACCTCATACATTTGCCTCCATACCTTAGA
ATGGACTTTTTGTTAAACCGAGGTGGTCCAGGCACCAGCAGGGACCTGAGCTTAGGACAAGCATGCTTGGAACCTCAGAAAAGCCGGACC
CTGAAGCGCCCCACGGTCCTGGAGCCCATCCCGATGGAAGCCGCCTCCTCCGCCTCCTCCACGAGAGAAGGACAGTCGTGGCAGCCGGGG
GCCGTGGCCACATTACCTCAGCGGGAGGGAGCAGAGCTGGGACAGGCAGCTAAAATGAGCAGCTCCCAAGAATCACTGCTCGACTCCCGG
GGCCATTTGAAAGGAAACAATCCTTACGCAAAATCTTACACCCTGGTATAACAGACAGCATGACTGGACAGCGGTTGTAAATACAATTCA
AACAATTCAATCAAAGCTACCTTTTTTTTACGGAATTCCAATATTTATAATTAAAGAAAATTGCCAAAATATATTAAAAAAAAAAAAGAG
AAAATACTGAAACCACAGACAGTGCAAAGACTCTCCTGCTTTTTTTCTGTCTGAGTGTGAGCTCCATCCGCCTGGGCATCTGATTTTTTG
GGAAAGAAGTCCAGTTTTATGATCTTCACAGGCTATTGCATTTTTACTGATTTTCTACAAAAGTGCATGGGGGGGATTAATTAAACCTTC
TGACTGGAAGTTCTATCACACAAGAGGCAAGAAAGAAAACAGGGTGGGTGGGAAATCAGCCTATTTGTGAATTTAAAAGGAACACCGATT
TGCGGGCAGGGGAAAACTTCAGTCACGTTTGCACACCTTTCTTTCCCATTAGAAACCGGGTTCTCAATTTGGTCTTCTTTTGTTGTTAAT
TAGGATGAGTGCCGTCAGTGAAGGGGTGGGGGGAATCAATTTGGTTTTCTCTCTTGTTTCTTTTTTAATTTAATGAGACACTCTTTGCAT
TTTGTCTAAGCGAAATAAAAAAGAAAAGGTTGTCTGCCTTTATTTCCATGTCTGCTTCTCTCGTCTTCTGCCAGTGGCCTGGTCCTCCTT
CCCATTGACACTTCTGTTTGGAAACACCAGGCCTGAACCCAGAGCCCAATTCAATAAACCAGAGTCGATACTAACACCCTGAACTCCTCA
GGAATCTCCAGGAAGCACAAAGAAGGTGCAGCTCCTGCTCTCAAGCTGGAGAGGACAAAATGCAGGCTGGTCTCCACCGCAACCAGAGGC
CAGCCCAAGTATTCGAAGCCCGTCGCAAAGCTCTGCCCCTTGCCTGCCCATGGCCAGAGTTCAACTGACTGTGGCCTATGGGCCAAATCC
AGCCTCCTGCTGTTTTTTAAATAAAGTTTTATTGAAACAAGGCCACATGCACTATTTGCTATTGTCTATGGCTGCTTTCATGGCACAATG
GTAGAGCTGAATAGTTGCAGCAGAGATGGTATAGCCCATGAAGCCTAAAATATTTATTACCTGGCCCATTACAGGAAACATTTGCCAGAC
CCGTGCTCTGGAGTCTGAAATGTAGCCCCAGCTTGCGTGACAAGGGGCAAGATCGTGCATCTTACCCTCCATGACTTTTCCTATCTCCAC
TATGCCTGGTATGCAAATTTGTGATAGACCATCTTAATAAACATTGCCTGAATCCTCTGTAACCAGAGGAAAGTGATGTTCCTCTAAAAT
CTAAGTTTTTACTTTCCTTTCCCTCACTTTATCTCCCATGTGGCTCATCCTAAGAGAGAATTTACTCATAAATAGTCGGAACTGCATTCT
TTATCCCACAACCCTCACAGGGTTTGCTTTATGAAAGAGGATGTAATCCTCCCCTGGCTGCAACACTCCATTCCAGGCTCACTTCCATAA
AATGGAAAGATAAACAGGTCTTTGTGTCAGAGATTTGGCATTAACCAGAAAACATGATCAAATATCCACAGCTGCTCAGTCTCCCAGGCT
GAAGATTCTCTACAGGCTTCCATTAAGGCCACCAACATAGACTGGTGCCAGTTATTACCATCTTGGGAACATATTCAGAAATGTCTTTCC
TTCCCTCCCTCCCTCCTTCTTTCCCATCCTTTCTTCCTTCTATTTATTTTCCAGGCAGGCCCATTTGTCTGCTTAGATTCAGTGACACAG
AATGGGTCCAGGACCATGTCAAGACCACCTGCTGATGCTAGTGTTAGATGACTCCAGGAATGTGAGGTGTGCATCCATGGTTTCAGAATG
TAATCCGTGTTGACGTGTACTGTTTGCATACTCTCAGACTGTTTTTTTTTTATGCAAAAGAAATGTTACTTTCTGGGGGAAAAAATTAAA
AGTCTATCTTTCATCAACCTAAAACTTCTATATCCCCCAAACATAGAAGTTTACCTTTTTAACATTTTTCTCTCAACCTGTACAAAAATA

>10342_10342_1_BRWD1-DSCAM_BRWD1_chr21_40641824_ENST00000333229_DSCAM_chr21_41385313_ENST00000400454_length(amino acids)=556AA_BP=541
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN

--------------------------------------------------------------
>10342_10342_2_BRWD1-DSCAM_BRWD1_chr21_40641824_ENST00000342449_DSCAM_chr21_41385313_ENST00000400454_length(transcript)=3997nt_BP=1609nt
CGCCAGCCCGGTCAGGCCTCGGCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCGCGCCCGGCCATGGCGGAGCC
GTCGTCCGCCCGACGCCCGGTGCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCGGCGGGCCCGTGTCGGAGAGC
GGCCCAGGTGCTGGTGCAGGAGCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAACGAGCACAACAGGAGCTACGA
GGAGTTGGTCTTGTCCAATAAGCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCTATGTTGGATAAAGAAATTCC
ACCCAGTATTTCAAGAGTCACTTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGACTGCAGGCACACAGTTTGGAA
GGGCTCTGCCTTTGCTGCTCTTCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCAAATCTTGTGGAGATACATCG
AGGAAAACAACTCACAGGGTGTTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAAATGCACAGAAGGATTCTCGG
ACATCTATCTGCTGTTTACTGTGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGACTGTTTGGTAAAGATTTGGTC
AACACATAATGGCCGCTTGTTATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAACTATGAGAATACAATGATTGC
TGCGGGGAGCTGTGATAAAATTATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAAGGACACACAGGATCAATTAC
ATCTTTACAGTTTAGCCCGATGGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACAGTTTGCTTTTGGCAATGGGA
TTTAGAATCCTTAAAATTTAGCCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATGCTTTGTTCTTCTTTTAGTGT
TGGTGGTATGTTTTTAGCCACAGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCACCCGAAAAAATCGCAGAACT
TGAAAGCCACACTGATAAAGTAGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGCAGAGATGGAACAGCACGGAT
TTGGAGATTTGAGCAGTTAGAATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTATCTTCCGAAGAGGAAAGGTT
TATGAAACCTAAAGTAACAATGATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGATCATGTCCTCAAAGTGTGGAA
TTCTTACACTGGACAACTGCTTCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACATCCCTTTGATTCCAGAATTAT
GTTATCTGCAGGACATGATGGCAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTATTTTAATATGGTGACCTCATA
CATTTGCCTCCATACCTTAGAATGGACTTTTTGTTAAACCGAGGTGGTCCAGGCACCAGCAGGGACCTGAGCTTAGGACAAGCATGCTTG
GAACCTCAGAAAAGCCGGACCCTGAAGCGCCCCACGGTCCTGGAGCCCATCCCGATGGAAGCCGCCTCCTCCGCCTCCTCCACGAGAGAA
GGACAGTCGTGGCAGCCGGGGGCCGTGGCCACATTACCTCAGCGGGAGGGAGCAGAGCTGGGACAGGCAGCTAAAATGAGCAGCTCCCAA
GAATCACTGCTCGACTCCCGGGGCCATTTGAAAGGAAACAATCCTTACGCAAAATCTTACACCCTGGTATAACAGACAGCATGACTGGAC
AGCGGTTGTAAATACAATTCAAACAATTCAATCAAAGCTACCTTTTTTTTACGGAATTCCAATATTTATAATTAAAGAAAATTGCCAAAA
TATATTAAAAAAAAAAAAGAGAAAATACTGAAACCACAGACAGTGCAAAGACTCTCCTGCTTTTTTTCTGTCTGAGTGTGAGCTCCATCC
GCCTGGGCATCTGATTTTTTGGGAAAGAAGTCCAGTTTTATGATCTTCACAGGCTATTGCATTTTTACTGATTTTCTACAAAAGTGCATG
GGGGGGATTAATTAAACCTTCTGACTGGAAGTTCTATCACACAAGAGGCAAGAAAGAAAACAGGGTGGGTGGGAAATCAGCCTATTTGTG
AATTTAAAAGGAACACCGATTTGCGGGCAGGGGAAAACTTCAGTCACGTTTGCACACCTTTCTTTCCCATTAGAAACCGGGTTCTCAATT
TGGTCTTCTTTTGTTGTTAATTAGGATGAGTGCCGTCAGTGAAGGGGTGGGGGGAATCAATTTGGTTTTCTCTCTTGTTTCTTTTTTAAT
TTAATGAGACACTCTTTGCATTTTGTCTAAGCGAAATAAAAAAGAAAAGGTTGTCTGCCTTTATTTCCATGTCTGCTTCTCTCGTCTTCT
GCCAGTGGCCTGGTCCTCCTTCCCATTGACACTTCTGTTTGGAAACACCAGGCCTGAACCCAGAGCCCAATTCAATAAACCAGAGTCGAT
ACTAACACCCTGAACTCCTCAGGAATCTCCAGGAAGCACAAAGAAGGTGCAGCTCCTGCTCTCAAGCTGGAGAGGACAAAATGCAGGCTG
GTCTCCACCGCAACCAGAGGCCAGCCCAAGTATTCGAAGCCCGTCGCAAAGCTCTGCCCCTTGCCTGCCCATGGCCAGAGTTCAACTGAC
TGTGGCCTATGGGCCAAATCCAGCCTCCTGCTGTTTTTTAAATAAAGTTTTATTGAAACAAGGCCACATGCACTATTTGCTATTGTCTAT
GGCTGCTTTCATGGCACAATGGTAGAGCTGAATAGTTGCAGCAGAGATGGTATAGCCCATGAAGCCTAAAATATTTATTACCTGGCCCAT
TACAGGAAACATTTGCCAGACCCGTGCTCTGGAGTCTGAAATGTAGCCCCAGCTTGCGTGACAAGGGGCAAGATCGTGCATCTTACCCTC
CATGACTTTTCCTATCTCCACTATGCCTGGTATGCAAATTTGTGATAGACCATCTTAATAAACATTGCCTGAATCCTCTGTAACCAGAGG
AAAGTGATGTTCCTCTAAAATCTAAGTTTTTACTTTCCTTTCCCTCACTTTATCTCCCATGTGGCTCATCCTAAGAGAGAATTTACTCAT
AAATAGTCGGAACTGCATTCTTTATCCCACAACCCTCACAGGGTTTGCTTTATGAAAGAGGATGTAATCCTCCCCTGGCTGCAACACTCC
ATTCCAGGCTCACTTCCATAAAATGGAAAGATAAACAGGTCTTTGTGTCAGAGATTTGGCATTAACCAGAAAACATGATCAAATATCCAC
AGCTGCTCAGTCTCCCAGGCTGAAGATTCTCTACAGGCTTCCATTAAGGCCACCAACATAGACTGGTGCCAGTTATTACCATCTTGGGAA
CATATTCAGAAATGTCTTTCCTTCCCTCCCTCCCTCCTTCTTTCCCATCCTTTCTTCCTTCTATTTATTTTCCAGGCAGGCCCATTTGTC
TGCTTAGATTCAGTGACACAGAATGGGTCCAGGACCATGTCAAGACCACCTGCTGATGCTAGTGTTAGATGACTCCAGGAATGTGAGGTG
TGCATCCATGGTTTCAGAATGTAATCCGTGTTGACGTGTACTGTTTGCATACTCTCAGACTGTTTTTTTTTTATGCAAAAGAAATGTTAC
TTTCTGGGGGAAAAAATTAAAAGTCTATCTTTCATCAACCTAAAACTTCTATATCCCCCAAACATAGAAGTTTACCTTTTTAACATTTTT

>10342_10342_2_BRWD1-DSCAM_BRWD1_chr21_40641824_ENST00000342449_DSCAM_chr21_41385313_ENST00000400454_length(amino acids)=525AA_BP=510
MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLD
KEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR
RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHT
GSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK
IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVL

--------------------------------------------------------------
>10342_10342_3_BRWD1-DSCAM_BRWD1_chr21_40641824_ENST00000380800_DSCAM_chr21_41385313_ENST00000400454_length(transcript)=4017nt_BP=1629nt
GCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCGGCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCG
CGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGTGCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCG
GCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGAGCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAAC
GAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAAGCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCT
ATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCACTTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGAC
TGCAGGCACACAGTTTGGAAGGGCTCTGCCTTTGCTGCTCTTCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCA
AATCTTGTGGAGATACATCGAGGAAAACAACTCACAGGGTGTTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAA
ATGCACAGAAGGATTCTCGGACATCTATCTGCTGTTTACTGTGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGAC
TGTTTGGTAAAGATTTGGTCAACACATAATGGCCGCTTGTTATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAAC
TATGAGAATACAATGATTGCTGCGGGGAGCTGTGATAAAATTATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAA
GGACACACAGGATCAATTACATCTTTACAGTTTAGCCCGATGGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACA
GTTTGCTTTTGGCAATGGGATTTAGAATCCTTAAAATTTAGCCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATG
CTTTGTTCTTCTTTTAGTGTTGGTGGTATGTTTTTAGCCACAGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCA
CCCGAAAAAATCGCAGAACTTGAAAGCCACACTGATAAAGTAGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGC
AGAGATGGAACAGCACGGATTTGGAGATTTGAGCAGTTAGAATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTA
TCTTCCGAAGAGGAAAGGTTTATGAAACCTAAAGTAACAATGATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGAT
CATGTCCTCAAAGTGTGGAATTCTTACACTGGACAACTGCTTCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACAT
CCCTTTGATTCCAGAATTATGTTATCTGCAGGACATGATGGCAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTAT
TTTAATATGGTGACCTCATACATTTGCCTCCATACCTTAGAATGGACTTTTTGTTAAACCGAGGTGGTCCAGGCACCAGCAGGGACCTGA
GCTTAGGACAAGCATGCTTGGAACCTCAGAAAAGCCGGACCCTGAAGCGCCCCACGGTCCTGGAGCCCATCCCGATGGAAGCCGCCTCCT
CCGCCTCCTCCACGAGAGAAGGACAGTCGTGGCAGCCGGGGGCCGTGGCCACATTACCTCAGCGGGAGGGAGCAGAGCTGGGACAGGCAG
CTAAAATGAGCAGCTCCCAAGAATCACTGCTCGACTCCCGGGGCCATTTGAAAGGAAACAATCCTTACGCAAAATCTTACACCCTGGTAT
AACAGACAGCATGACTGGACAGCGGTTGTAAATACAATTCAAACAATTCAATCAAAGCTACCTTTTTTTTACGGAATTCCAATATTTATA
ATTAAAGAAAATTGCCAAAATATATTAAAAAAAAAAAAGAGAAAATACTGAAACCACAGACAGTGCAAAGACTCTCCTGCTTTTTTTCTG
TCTGAGTGTGAGCTCCATCCGCCTGGGCATCTGATTTTTTGGGAAAGAAGTCCAGTTTTATGATCTTCACAGGCTATTGCATTTTTACTG
ATTTTCTACAAAAGTGCATGGGGGGGATTAATTAAACCTTCTGACTGGAAGTTCTATCACACAAGAGGCAAGAAAGAAAACAGGGTGGGT
GGGAAATCAGCCTATTTGTGAATTTAAAAGGAACACCGATTTGCGGGCAGGGGAAAACTTCAGTCACGTTTGCACACCTTTCTTTCCCAT
TAGAAACCGGGTTCTCAATTTGGTCTTCTTTTGTTGTTAATTAGGATGAGTGCCGTCAGTGAAGGGGTGGGGGGAATCAATTTGGTTTTC
TCTCTTGTTTCTTTTTTAATTTAATGAGACACTCTTTGCATTTTGTCTAAGCGAAATAAAAAAGAAAAGGTTGTCTGCCTTTATTTCCAT
GTCTGCTTCTCTCGTCTTCTGCCAGTGGCCTGGTCCTCCTTCCCATTGACACTTCTGTTTGGAAACACCAGGCCTGAACCCAGAGCCCAA
TTCAATAAACCAGAGTCGATACTAACACCCTGAACTCCTCAGGAATCTCCAGGAAGCACAAAGAAGGTGCAGCTCCTGCTCTCAAGCTGG
AGAGGACAAAATGCAGGCTGGTCTCCACCGCAACCAGAGGCCAGCCCAAGTATTCGAAGCCCGTCGCAAAGCTCTGCCCCTTGCCTGCCC
ATGGCCAGAGTTCAACTGACTGTGGCCTATGGGCCAAATCCAGCCTCCTGCTGTTTTTTAAATAAAGTTTTATTGAAACAAGGCCACATG
CACTATTTGCTATTGTCTATGGCTGCTTTCATGGCACAATGGTAGAGCTGAATAGTTGCAGCAGAGATGGTATAGCCCATGAAGCCTAAA
ATATTTATTACCTGGCCCATTACAGGAAACATTTGCCAGACCCGTGCTCTGGAGTCTGAAATGTAGCCCCAGCTTGCGTGACAAGGGGCA
AGATCGTGCATCTTACCCTCCATGACTTTTCCTATCTCCACTATGCCTGGTATGCAAATTTGTGATAGACCATCTTAATAAACATTGCCT
GAATCCTCTGTAACCAGAGGAAAGTGATGTTCCTCTAAAATCTAAGTTTTTACTTTCCTTTCCCTCACTTTATCTCCCATGTGGCTCATC
CTAAGAGAGAATTTACTCATAAATAGTCGGAACTGCATTCTTTATCCCACAACCCTCACAGGGTTTGCTTTATGAAAGAGGATGTAATCC
TCCCCTGGCTGCAACACTCCATTCCAGGCTCACTTCCATAAAATGGAAAGATAAACAGGTCTTTGTGTCAGAGATTTGGCATTAACCAGA
AAACATGATCAAATATCCACAGCTGCTCAGTCTCCCAGGCTGAAGATTCTCTACAGGCTTCCATTAAGGCCACCAACATAGACTGGTGCC
AGTTATTACCATCTTGGGAACATATTCAGAAATGTCTTTCCTTCCCTCCCTCCCTCCTTCTTTCCCATCCTTTCTTCCTTCTATTTATTT
TCCAGGCAGGCCCATTTGTCTGCTTAGATTCAGTGACACAGAATGGGTCCAGGACCATGTCAAGACCACCTGCTGATGCTAGTGTTAGAT
GACTCCAGGAATGTGAGGTGTGCATCCATGGTTTCAGAATGTAATCCGTGTTGACGTGTACTGTTTGCATACTCTCAGACTGTTTTTTTT
TTATGCAAAAGAAATGTTACTTTCTGGGGGAAAAAATTAAAAGTCTATCTTTCATCAACCTAAAACTTCTATATCCCCCAAACATAGAAG

>10342_10342_3_BRWD1-DSCAM_BRWD1_chr21_40641824_ENST00000380800_DSCAM_chr21_41385313_ENST00000400454_length(amino acids)=556AA_BP=541
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN

--------------------------------------------------------------
>10342_10342_4_BRWD1-DSCAM_BRWD1_chr21_40641825_ENST00000333229_DSCAM_chr21_41385313_ENST00000400454_length(transcript)=4246nt_BP=1858nt
AGGTCTTTGCCTCCGCGTCACTTTCTCCTCATCGAGTCCCCGGAGGCAGAGAGCTGAGCGAGGTTCGCCTCCCCGGGCGGGACACGAGCT
CCGGTCCTCTCTTGGCGCAAACCCCCGCCCCCCGCGGAGGGACTACTTTTCGTCTCCCGCGGAGGAACTACTTCCTCCCCCGCGGAGGCG
TCGGTCCAGGCGGCGCGCACGGTATGGCGGCGGCGGCGGCGGCGGCGGCGCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCG
GCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCGCGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGT
GCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCGGCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGA
GCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAACGAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAA
GCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCTATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCAC
TTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGACTGCAGGCACACAGTTTGGAAGGGCTCTGCCTTTGCTGCTCT
TCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCAAATCTTGTGGAGATACATCGAGGAAAACAACTCACAGGGTG
TTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAAATGCACAGAAGGATTCTCGGACATCTATCTGCTGTTTACTG
TGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGACTGTTTGGTAAAGATTTGGTCAACACATAATGGCCGCTTGTT
ATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAACTATGAGAATACAATGATTGCTGCGGGGAGCTGTGATAAAAT
TATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAAGGACACACAGGATCAATTACATCTTTACAGTTTAGCCCGAT
GGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACAGTTTGCTTTTGGCAATGGGATTTAGAATCCTTAAAATTTAG
CCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATGCTTTGTTCTTCTTTTAGTGTTGGTGGTATGTTTTTAGCCAC
AGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCACCCGAAAAAATCGCAGAACTTGAAAGCCACACTGATAAAGT
AGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGCAGAGATGGAACAGCACGGATTTGGAGATTTGAGCAGTTAGA
ATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTATCTTCCGAAGAGGAAAGGTTTATGAAACCTAAAGTAACAAT
GATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGATCATGTCCTCAAAGTGTGGAATTCTTACACTGGACAACTGCT
TCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACATCCCTTTGATTCCAGAATTATGTTATCTGCAGGACATGATGG
CAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTATTTTAATATGGTGACCTCATACATTTGCCTCCATACCTTAGA
ATGGACTTTTTGTTAAACCGAGGTGGTCCAGGCACCAGCAGGGACCTGAGCTTAGGACAAGCATGCTTGGAACCTCAGAAAAGCCGGACC
CTGAAGCGCCCCACGGTCCTGGAGCCCATCCCGATGGAAGCCGCCTCCTCCGCCTCCTCCACGAGAGAAGGACAGTCGTGGCAGCCGGGG
GCCGTGGCCACATTACCTCAGCGGGAGGGAGCAGAGCTGGGACAGGCAGCTAAAATGAGCAGCTCCCAAGAATCACTGCTCGACTCCCGG
GGCCATTTGAAAGGAAACAATCCTTACGCAAAATCTTACACCCTGGTATAACAGACAGCATGACTGGACAGCGGTTGTAAATACAATTCA
AACAATTCAATCAAAGCTACCTTTTTTTTACGGAATTCCAATATTTATAATTAAAGAAAATTGCCAAAATATATTAAAAAAAAAAAAGAG
AAAATACTGAAACCACAGACAGTGCAAAGACTCTCCTGCTTTTTTTCTGTCTGAGTGTGAGCTCCATCCGCCTGGGCATCTGATTTTTTG
GGAAAGAAGTCCAGTTTTATGATCTTCACAGGCTATTGCATTTTTACTGATTTTCTACAAAAGTGCATGGGGGGGATTAATTAAACCTTC
TGACTGGAAGTTCTATCACACAAGAGGCAAGAAAGAAAACAGGGTGGGTGGGAAATCAGCCTATTTGTGAATTTAAAAGGAACACCGATT
TGCGGGCAGGGGAAAACTTCAGTCACGTTTGCACACCTTTCTTTCCCATTAGAAACCGGGTTCTCAATTTGGTCTTCTTTTGTTGTTAAT
TAGGATGAGTGCCGTCAGTGAAGGGGTGGGGGGAATCAATTTGGTTTTCTCTCTTGTTTCTTTTTTAATTTAATGAGACACTCTTTGCAT
TTTGTCTAAGCGAAATAAAAAAGAAAAGGTTGTCTGCCTTTATTTCCATGTCTGCTTCTCTCGTCTTCTGCCAGTGGCCTGGTCCTCCTT
CCCATTGACACTTCTGTTTGGAAACACCAGGCCTGAACCCAGAGCCCAATTCAATAAACCAGAGTCGATACTAACACCCTGAACTCCTCA
GGAATCTCCAGGAAGCACAAAGAAGGTGCAGCTCCTGCTCTCAAGCTGGAGAGGACAAAATGCAGGCTGGTCTCCACCGCAACCAGAGGC
CAGCCCAAGTATTCGAAGCCCGTCGCAAAGCTCTGCCCCTTGCCTGCCCATGGCCAGAGTTCAACTGACTGTGGCCTATGGGCCAAATCC
AGCCTCCTGCTGTTTTTTAAATAAAGTTTTATTGAAACAAGGCCACATGCACTATTTGCTATTGTCTATGGCTGCTTTCATGGCACAATG
GTAGAGCTGAATAGTTGCAGCAGAGATGGTATAGCCCATGAAGCCTAAAATATTTATTACCTGGCCCATTACAGGAAACATTTGCCAGAC
CCGTGCTCTGGAGTCTGAAATGTAGCCCCAGCTTGCGTGACAAGGGGCAAGATCGTGCATCTTACCCTCCATGACTTTTCCTATCTCCAC
TATGCCTGGTATGCAAATTTGTGATAGACCATCTTAATAAACATTGCCTGAATCCTCTGTAACCAGAGGAAAGTGATGTTCCTCTAAAAT
CTAAGTTTTTACTTTCCTTTCCCTCACTTTATCTCCCATGTGGCTCATCCTAAGAGAGAATTTACTCATAAATAGTCGGAACTGCATTCT
TTATCCCACAACCCTCACAGGGTTTGCTTTATGAAAGAGGATGTAATCCTCCCCTGGCTGCAACACTCCATTCCAGGCTCACTTCCATAA
AATGGAAAGATAAACAGGTCTTTGTGTCAGAGATTTGGCATTAACCAGAAAACATGATCAAATATCCACAGCTGCTCAGTCTCCCAGGCT
GAAGATTCTCTACAGGCTTCCATTAAGGCCACCAACATAGACTGGTGCCAGTTATTACCATCTTGGGAACATATTCAGAAATGTCTTTCC
TTCCCTCCCTCCCTCCTTCTTTCCCATCCTTTCTTCCTTCTATTTATTTTCCAGGCAGGCCCATTTGTCTGCTTAGATTCAGTGACACAG
AATGGGTCCAGGACCATGTCAAGACCACCTGCTGATGCTAGTGTTAGATGACTCCAGGAATGTGAGGTGTGCATCCATGGTTTCAGAATG
TAATCCGTGTTGACGTGTACTGTTTGCATACTCTCAGACTGTTTTTTTTTTATGCAAAAGAAATGTTACTTTCTGGGGGAAAAAATTAAA
AGTCTATCTTTCATCAACCTAAAACTTCTATATCCCCCAAACATAGAAGTTTACCTTTTTAACATTTTTCTCTCAACCTGTACAAAAATA

>10342_10342_4_BRWD1-DSCAM_BRWD1_chr21_40641825_ENST00000333229_DSCAM_chr21_41385313_ENST00000400454_length(amino acids)=556AA_BP=541
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN

--------------------------------------------------------------
>10342_10342_5_BRWD1-DSCAM_BRWD1_chr21_40641825_ENST00000342449_DSCAM_chr21_41385313_ENST00000400454_length(transcript)=3997nt_BP=1609nt
CGCCAGCCCGGTCAGGCCTCGGCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCGCGCCCGGCCATGGCGGAGCC
GTCGTCCGCCCGACGCCCGGTGCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCGGCGGGCCCGTGTCGGAGAGC
GGCCCAGGTGCTGGTGCAGGAGCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAACGAGCACAACAGGAGCTACGA
GGAGTTGGTCTTGTCCAATAAGCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCTATGTTGGATAAAGAAATTCC
ACCCAGTATTTCAAGAGTCACTTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGACTGCAGGCACACAGTTTGGAA
GGGCTCTGCCTTTGCTGCTCTTCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCAAATCTTGTGGAGATACATCG
AGGAAAACAACTCACAGGGTGTTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAAATGCACAGAAGGATTCTCGG
ACATCTATCTGCTGTTTACTGTGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGACTGTTTGGTAAAGATTTGGTC
AACACATAATGGCCGCTTGTTATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAACTATGAGAATACAATGATTGC
TGCGGGGAGCTGTGATAAAATTATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAAGGACACACAGGATCAATTAC
ATCTTTACAGTTTAGCCCGATGGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACAGTTTGCTTTTGGCAATGGGA
TTTAGAATCCTTAAAATTTAGCCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATGCTTTGTTCTTCTTTTAGTGT
TGGTGGTATGTTTTTAGCCACAGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCACCCGAAAAAATCGCAGAACT
TGAAAGCCACACTGATAAAGTAGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGCAGAGATGGAACAGCACGGAT
TTGGAGATTTGAGCAGTTAGAATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTATCTTCCGAAGAGGAAAGGTT
TATGAAACCTAAAGTAACAATGATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGATCATGTCCTCAAAGTGTGGAA
TTCTTACACTGGACAACTGCTTCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACATCCCTTTGATTCCAGAATTAT
GTTATCTGCAGGACATGATGGCAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTATTTTAATATGGTGACCTCATA
CATTTGCCTCCATACCTTAGAATGGACTTTTTGTTAAACCGAGGTGGTCCAGGCACCAGCAGGGACCTGAGCTTAGGACAAGCATGCTTG
GAACCTCAGAAAAGCCGGACCCTGAAGCGCCCCACGGTCCTGGAGCCCATCCCGATGGAAGCCGCCTCCTCCGCCTCCTCCACGAGAGAA
GGACAGTCGTGGCAGCCGGGGGCCGTGGCCACATTACCTCAGCGGGAGGGAGCAGAGCTGGGACAGGCAGCTAAAATGAGCAGCTCCCAA
GAATCACTGCTCGACTCCCGGGGCCATTTGAAAGGAAACAATCCTTACGCAAAATCTTACACCCTGGTATAACAGACAGCATGACTGGAC
AGCGGTTGTAAATACAATTCAAACAATTCAATCAAAGCTACCTTTTTTTTACGGAATTCCAATATTTATAATTAAAGAAAATTGCCAAAA
TATATTAAAAAAAAAAAAGAGAAAATACTGAAACCACAGACAGTGCAAAGACTCTCCTGCTTTTTTTCTGTCTGAGTGTGAGCTCCATCC
GCCTGGGCATCTGATTTTTTGGGAAAGAAGTCCAGTTTTATGATCTTCACAGGCTATTGCATTTTTACTGATTTTCTACAAAAGTGCATG
GGGGGGATTAATTAAACCTTCTGACTGGAAGTTCTATCACACAAGAGGCAAGAAAGAAAACAGGGTGGGTGGGAAATCAGCCTATTTGTG
AATTTAAAAGGAACACCGATTTGCGGGCAGGGGAAAACTTCAGTCACGTTTGCACACCTTTCTTTCCCATTAGAAACCGGGTTCTCAATT
TGGTCTTCTTTTGTTGTTAATTAGGATGAGTGCCGTCAGTGAAGGGGTGGGGGGAATCAATTTGGTTTTCTCTCTTGTTTCTTTTTTAAT
TTAATGAGACACTCTTTGCATTTTGTCTAAGCGAAATAAAAAAGAAAAGGTTGTCTGCCTTTATTTCCATGTCTGCTTCTCTCGTCTTCT
GCCAGTGGCCTGGTCCTCCTTCCCATTGACACTTCTGTTTGGAAACACCAGGCCTGAACCCAGAGCCCAATTCAATAAACCAGAGTCGAT
ACTAACACCCTGAACTCCTCAGGAATCTCCAGGAAGCACAAAGAAGGTGCAGCTCCTGCTCTCAAGCTGGAGAGGACAAAATGCAGGCTG
GTCTCCACCGCAACCAGAGGCCAGCCCAAGTATTCGAAGCCCGTCGCAAAGCTCTGCCCCTTGCCTGCCCATGGCCAGAGTTCAACTGAC
TGTGGCCTATGGGCCAAATCCAGCCTCCTGCTGTTTTTTAAATAAAGTTTTATTGAAACAAGGCCACATGCACTATTTGCTATTGTCTAT
GGCTGCTTTCATGGCACAATGGTAGAGCTGAATAGTTGCAGCAGAGATGGTATAGCCCATGAAGCCTAAAATATTTATTACCTGGCCCAT
TACAGGAAACATTTGCCAGACCCGTGCTCTGGAGTCTGAAATGTAGCCCCAGCTTGCGTGACAAGGGGCAAGATCGTGCATCTTACCCTC
CATGACTTTTCCTATCTCCACTATGCCTGGTATGCAAATTTGTGATAGACCATCTTAATAAACATTGCCTGAATCCTCTGTAACCAGAGG
AAAGTGATGTTCCTCTAAAATCTAAGTTTTTACTTTCCTTTCCCTCACTTTATCTCCCATGTGGCTCATCCTAAGAGAGAATTTACTCAT
AAATAGTCGGAACTGCATTCTTTATCCCACAACCCTCACAGGGTTTGCTTTATGAAAGAGGATGTAATCCTCCCCTGGCTGCAACACTCC
ATTCCAGGCTCACTTCCATAAAATGGAAAGATAAACAGGTCTTTGTGTCAGAGATTTGGCATTAACCAGAAAACATGATCAAATATCCAC
AGCTGCTCAGTCTCCCAGGCTGAAGATTCTCTACAGGCTTCCATTAAGGCCACCAACATAGACTGGTGCCAGTTATTACCATCTTGGGAA
CATATTCAGAAATGTCTTTCCTTCCCTCCCTCCCTCCTTCTTTCCCATCCTTTCTTCCTTCTATTTATTTTCCAGGCAGGCCCATTTGTC
TGCTTAGATTCAGTGACACAGAATGGGTCCAGGACCATGTCAAGACCACCTGCTGATGCTAGTGTTAGATGACTCCAGGAATGTGAGGTG
TGCATCCATGGTTTCAGAATGTAATCCGTGTTGACGTGTACTGTTTGCATACTCTCAGACTGTTTTTTTTTTATGCAAAAGAAATGTTAC
TTTCTGGGGGAAAAAATTAAAAGTCTATCTTTCATCAACCTAAAACTTCTATATCCCCCAAACATAGAAGTTTACCTTTTTAACATTTTT

>10342_10342_5_BRWD1-DSCAM_BRWD1_chr21_40641825_ENST00000342449_DSCAM_chr21_41385313_ENST00000400454_length(amino acids)=525AA_BP=510
MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLD
KEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR
RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHT
GSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK
IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVL

--------------------------------------------------------------
>10342_10342_6_BRWD1-DSCAM_BRWD1_chr21_40641825_ENST00000380800_DSCAM_chr21_41385313_ENST00000400454_length(transcript)=4017nt_BP=1629nt
GCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCGGCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCG
CGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGTGCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCG
GCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGAGCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAAC
GAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAAGCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCT
ATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCACTTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGAC
TGCAGGCACACAGTTTGGAAGGGCTCTGCCTTTGCTGCTCTTCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCA
AATCTTGTGGAGATACATCGAGGAAAACAACTCACAGGGTGTTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAA
ATGCACAGAAGGATTCTCGGACATCTATCTGCTGTTTACTGTGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGAC
TGTTTGGTAAAGATTTGGTCAACACATAATGGCCGCTTGTTATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAAC
TATGAGAATACAATGATTGCTGCGGGGAGCTGTGATAAAATTATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAA
GGACACACAGGATCAATTACATCTTTACAGTTTAGCCCGATGGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACA
GTTTGCTTTTGGCAATGGGATTTAGAATCCTTAAAATTTAGCCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATG
CTTTGTTCTTCTTTTAGTGTTGGTGGTATGTTTTTAGCCACAGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCA
CCCGAAAAAATCGCAGAACTTGAAAGCCACACTGATAAAGTAGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGC
AGAGATGGAACAGCACGGATTTGGAGATTTGAGCAGTTAGAATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTA
TCTTCCGAAGAGGAAAGGTTTATGAAACCTAAAGTAACAATGATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGAT
CATGTCCTCAAAGTGTGGAATTCTTACACTGGACAACTGCTTCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACAT
CCCTTTGATTCCAGAATTATGTTATCTGCAGGACATGATGGCAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTAT
TTTAATATGGTGACCTCATACATTTGCCTCCATACCTTAGAATGGACTTTTTGTTAAACCGAGGTGGTCCAGGCACCAGCAGGGACCTGA
GCTTAGGACAAGCATGCTTGGAACCTCAGAAAAGCCGGACCCTGAAGCGCCCCACGGTCCTGGAGCCCATCCCGATGGAAGCCGCCTCCT
CCGCCTCCTCCACGAGAGAAGGACAGTCGTGGCAGCCGGGGGCCGTGGCCACATTACCTCAGCGGGAGGGAGCAGAGCTGGGACAGGCAG
CTAAAATGAGCAGCTCCCAAGAATCACTGCTCGACTCCCGGGGCCATTTGAAAGGAAACAATCCTTACGCAAAATCTTACACCCTGGTAT
AACAGACAGCATGACTGGACAGCGGTTGTAAATACAATTCAAACAATTCAATCAAAGCTACCTTTTTTTTACGGAATTCCAATATTTATA
ATTAAAGAAAATTGCCAAAATATATTAAAAAAAAAAAAGAGAAAATACTGAAACCACAGACAGTGCAAAGACTCTCCTGCTTTTTTTCTG
TCTGAGTGTGAGCTCCATCCGCCTGGGCATCTGATTTTTTGGGAAAGAAGTCCAGTTTTATGATCTTCACAGGCTATTGCATTTTTACTG
ATTTTCTACAAAAGTGCATGGGGGGGATTAATTAAACCTTCTGACTGGAAGTTCTATCACACAAGAGGCAAGAAAGAAAACAGGGTGGGT
GGGAAATCAGCCTATTTGTGAATTTAAAAGGAACACCGATTTGCGGGCAGGGGAAAACTTCAGTCACGTTTGCACACCTTTCTTTCCCAT
TAGAAACCGGGTTCTCAATTTGGTCTTCTTTTGTTGTTAATTAGGATGAGTGCCGTCAGTGAAGGGGTGGGGGGAATCAATTTGGTTTTC
TCTCTTGTTTCTTTTTTAATTTAATGAGACACTCTTTGCATTTTGTCTAAGCGAAATAAAAAAGAAAAGGTTGTCTGCCTTTATTTCCAT
GTCTGCTTCTCTCGTCTTCTGCCAGTGGCCTGGTCCTCCTTCCCATTGACACTTCTGTTTGGAAACACCAGGCCTGAACCCAGAGCCCAA
TTCAATAAACCAGAGTCGATACTAACACCCTGAACTCCTCAGGAATCTCCAGGAAGCACAAAGAAGGTGCAGCTCCTGCTCTCAAGCTGG
AGAGGACAAAATGCAGGCTGGTCTCCACCGCAACCAGAGGCCAGCCCAAGTATTCGAAGCCCGTCGCAAAGCTCTGCCCCTTGCCTGCCC
ATGGCCAGAGTTCAACTGACTGTGGCCTATGGGCCAAATCCAGCCTCCTGCTGTTTTTTAAATAAAGTTTTATTGAAACAAGGCCACATG
CACTATTTGCTATTGTCTATGGCTGCTTTCATGGCACAATGGTAGAGCTGAATAGTTGCAGCAGAGATGGTATAGCCCATGAAGCCTAAA
ATATTTATTACCTGGCCCATTACAGGAAACATTTGCCAGACCCGTGCTCTGGAGTCTGAAATGTAGCCCCAGCTTGCGTGACAAGGGGCA
AGATCGTGCATCTTACCCTCCATGACTTTTCCTATCTCCACTATGCCTGGTATGCAAATTTGTGATAGACCATCTTAATAAACATTGCCT
GAATCCTCTGTAACCAGAGGAAAGTGATGTTCCTCTAAAATCTAAGTTTTTACTTTCCTTTCCCTCACTTTATCTCCCATGTGGCTCATC
CTAAGAGAGAATTTACTCATAAATAGTCGGAACTGCATTCTTTATCCCACAACCCTCACAGGGTTTGCTTTATGAAAGAGGATGTAATCC
TCCCCTGGCTGCAACACTCCATTCCAGGCTCACTTCCATAAAATGGAAAGATAAACAGGTCTTTGTGTCAGAGATTTGGCATTAACCAGA
AAACATGATCAAATATCCACAGCTGCTCAGTCTCCCAGGCTGAAGATTCTCTACAGGCTTCCATTAAGGCCACCAACATAGACTGGTGCC
AGTTATTACCATCTTGGGAACATATTCAGAAATGTCTTTCCTTCCCTCCCTCCCTCCTTCTTTCCCATCCTTTCTTCCTTCTATTTATTT
TCCAGGCAGGCCCATTTGTCTGCTTAGATTCAGTGACACAGAATGGGTCCAGGACCATGTCAAGACCACCTGCTGATGCTAGTGTTAGAT
GACTCCAGGAATGTGAGGTGTGCATCCATGGTTTCAGAATGTAATCCGTGTTGACGTGTACTGTTTGCATACTCTCAGACTGTTTTTTTT
TTATGCAAAAGAAATGTTACTTTCTGGGGGAAAAAATTAAAAGTCTATCTTTCATCAACCTAAAACTTCTATATCCCCCAAACATAGAAG

>10342_10342_6_BRWD1-DSCAM_BRWD1_chr21_40641825_ENST00000380800_DSCAM_chr21_41385313_ENST00000400454_length(amino acids)=556AA_BP=541
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN

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Fusion Gene PPI Analysis for BRWD1-DSCAM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRWD1-DSCAM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRWD1-DSCAM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRWD1C0028960Oligospermia1CTD_human
TgeneC0005586Bipolar Disorder1PSYGENET
TgeneC0013146Drug abuse1CTD_human
TgeneC0013170Drug habituation1CTD_human
TgeneC0013222Drug Use Disorders1CTD_human
TgeneC0019209Hepatomegaly1CTD_human
TgeneC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneC0038580Substance Dependence1CTD_human
TgeneC0038586Substance Use Disorders1CTD_human
TgeneC0236969Substance-Related Disorders1CTD_human
TgeneC0740858Substance abuse problem1CTD_human
TgeneC1510472Drug Dependence1CTD_human
TgeneC1535926Neurodevelopmental Disorders1CTD_human
TgeneC4316881Prescription Drug Abuse1CTD_human