Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:BRWD1-CHMP1A (FusionGDB2 ID:HG54014TG5119)

Fusion Gene Summary for BRWD1-CHMP1A

check button Fusion gene summary
Fusion gene informationFusion gene name: BRWD1-CHMP1A
Fusion gene ID: hg54014tg5119
HgeneTgene
Gene symbol

BRWD1

CHMP1A

Gene ID

54014

5119

Gene namebromodomain and WD repeat domain containing 1charged multivesicular body protein 1A
SynonymsC21orf107|DCAF19|N143|WDR9|WRD9CHMP1|PCH8|PCOLN3|PRSM1|VPS46-1|VPS46A
Cytomap('BRWD1')('CHMP1A')

21q22.2

16q24.3

Type of geneprotein-codingprotein-coding
Descriptionbromodomain and WD repeat-containing protein 1WD repeat protein WDR9-form2WD repeat-containing protein 9transcriptional unit N143charged multivesicular body protein 1acharged multivesicular body protein 1/chromatin modifying protein 1chromatin modifying protein 1Aprocollagen (type III) N-endopeptidaseprotease, metallo, 1, 33kDvacuolar protein sorting-associated protein 46-1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000333229, ENST00000342449, 
ENST00000380800, ENST00000341322, 
ENST00000470108, 
Fusion gene scores* DoF score28 X 28 X 10=784045 X 11 X 21=10395
# samples 3248
** MAII scorelog2(32/7840*10)=-4.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/10395*10)=-4.43671154213721
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRWD1 [Title/Abstract] AND CHMP1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRWD1(40670358)-CHMP1A(89713739), # samples:1
Anticipated loss of major functional domain due to fusion event.BRWD1-CHMP1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRWD1-CHMP1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRWD1-CHMP1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BRWD1-CHMP1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BRWD1-CHMP1A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
BRWD1-CHMP1A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BRWD1-CHMP1A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCHMP1A

GO:0007076

mitotic chromosome condensation

11559747

TgeneCHMP1A

GO:0016192

vesicle-mediated transport

11559748

TgeneCHMP1A

GO:0016458

gene silencing

11559747

TgeneCHMP1A

GO:0045892

negative regulation of transcription, DNA-templated

11559747


check buttonFusion gene breakpoints across BRWD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CHMP1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-IN-8462-11ABRWD1chr21

40670358

-CHMP1Achr16

89713739

-


Top

Fusion Gene ORF analysis for BRWD1-CHMP1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000333229ENST00000547614BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
5CDS-5UTRENST00000342449ENST00000547614BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
5CDS-5UTRENST00000380800ENST00000547614BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
Frame-shiftENST00000333229ENST00000397901BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
Frame-shiftENST00000333229ENST00000535997BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
Frame-shiftENST00000333229ENST00000550102BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
Frame-shiftENST00000342449ENST00000397901BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
Frame-shiftENST00000342449ENST00000535997BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
Frame-shiftENST00000342449ENST00000550102BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
Frame-shiftENST00000380800ENST00000397901BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
Frame-shiftENST00000380800ENST00000535997BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
Frame-shiftENST00000380800ENST00000550102BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
In-frameENST00000333229ENST00000253475BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
In-frameENST00000342449ENST00000253475BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
In-frameENST00000380800ENST00000253475BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
intron-3CDSENST00000341322ENST00000253475BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
intron-3CDSENST00000341322ENST00000397901BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
intron-3CDSENST00000341322ENST00000535997BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
intron-3CDSENST00000341322ENST00000550102BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
intron-3CDSENST00000470108ENST00000253475BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
intron-3CDSENST00000470108ENST00000397901BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
intron-3CDSENST00000470108ENST00000535997BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
intron-3CDSENST00000470108ENST00000550102BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
intron-5UTRENST00000341322ENST00000547614BRWD1chr21

40670358

-CHMP1Achr16

89713739

-
intron-5UTRENST00000470108ENST00000547614BRWD1chr21

40670358

-CHMP1Achr16

89713739

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000333229BRWD1chr2140670358-ENST00000253475CHMP1Achr1689713739-26446772351167310
ENST00000342449BRWD1chr2140670358-ENST00000253475CHMP1Achr1689713739-239542879918279
ENST00000380800BRWD1chr2140670358-ENST00000253475CHMP1Achr1689713739-24154486938310

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000333229ENST00000253475BRWD1chr2140670358-CHMP1Achr1689713739-0.31443390.68556607
ENST00000342449ENST00000253475BRWD1chr2140670358-CHMP1Achr1689713739-0.329835270.6701647
ENST00000380800ENST00000253475BRWD1chr2140670358-CHMP1Achr1689713739-0.328833220.6711668

Top

Fusion Genomic Features for BRWD1-CHMP1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for BRWD1-CHMP1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:40670358/chr16:89713739)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCHMP1Achr21:40670358chr16:89713739ENST0000039790137102_12484197.0Coiled coilOntology_term=ECO:0000255
TgeneCHMP1Achr21:40670358chr16:89713739ENST0000039790137185_19584197.0MotifNote=MIT-interacting motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRWD1chr21:40670358chr16:89713739ENST00000333229-5421539_15481162321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40670358chr16:89713739ENST00000333229-5421687_16921162321.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40670358chr16:89713739ENST00000333229-542661_6681162321.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40670358chr16:89713739ENST00000333229-542821_8241162321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40670358chr16:89713739ENST00000341322-151539_15480121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40670358chr16:89713739ENST00000341322-151687_16920121.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40670358chr16:89713739ENST00000341322-15661_6680121.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40670358chr16:89713739ENST00000341322-15821_8240121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40670358chr16:89713739ENST00000342449-5411539_15481162270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40670358chr16:89713739ENST00000342449-5411687_16921162270.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40670358chr16:89713739ENST00000342449-541661_6681162270.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40670358chr16:89713739ENST00000342449-541821_8241162270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40670358chr16:89713739ENST00000380800-5421539_15481162200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40670358chr16:89713739ENST00000380800-5421687_16921162200.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40670358chr16:89713739ENST00000380800-542661_6681162200.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40670358chr16:89713739ENST00000380800-542821_8241162200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40670358chr16:89713739ENST00000333229-5421177_12471162321.0DomainBromo 1
HgeneBRWD1chr21:40670358chr16:89713739ENST00000333229-5421330_14001162321.0DomainBromo 2
HgeneBRWD1chr21:40670358chr16:89713739ENST00000341322-151177_12470121.0DomainBromo 1
HgeneBRWD1chr21:40670358chr16:89713739ENST00000341322-151330_14000121.0DomainBromo 2
HgeneBRWD1chr21:40670358chr16:89713739ENST00000342449-5411177_12471162270.0DomainBromo 1
HgeneBRWD1chr21:40670358chr16:89713739ENST00000342449-5411330_14001162270.0DomainBromo 2
HgeneBRWD1chr21:40670358chr16:89713739ENST00000380800-5421177_12471162200.0DomainBromo 1
HgeneBRWD1chr21:40670358chr16:89713739ENST00000380800-5421330_14001162200.0DomainBromo 2
HgeneBRWD1chr21:40670358chr16:89713739ENST00000333229-542184_2231162321.0RepeatNote=WD 1
HgeneBRWD1chr21:40670358chr16:89713739ENST00000333229-542226_2651162321.0RepeatNote=WD 2
HgeneBRWD1chr21:40670358chr16:89713739ENST00000333229-542268_3111162321.0RepeatNote=WD 3
HgeneBRWD1chr21:40670358chr16:89713739ENST00000333229-542322_3651162321.0RepeatNote=WD 4
HgeneBRWD1chr21:40670358chr16:89713739ENST00000333229-542366_4051162321.0RepeatNote=WD 5
HgeneBRWD1chr21:40670358chr16:89713739ENST00000333229-542424_4631162321.0RepeatNote=WD 6
HgeneBRWD1chr21:40670358chr16:89713739ENST00000333229-542466_5061162321.0RepeatNote=WD 7
HgeneBRWD1chr21:40670358chr16:89713739ENST00000333229-542514_5531162321.0RepeatNote=WD 8
HgeneBRWD1chr21:40670358chr16:89713739ENST00000341322-15184_2230121.0RepeatNote=WD 1
HgeneBRWD1chr21:40670358chr16:89713739ENST00000341322-15226_2650121.0RepeatNote=WD 2
HgeneBRWD1chr21:40670358chr16:89713739ENST00000341322-15268_3110121.0RepeatNote=WD 3
HgeneBRWD1chr21:40670358chr16:89713739ENST00000341322-15322_3650121.0RepeatNote=WD 4
HgeneBRWD1chr21:40670358chr16:89713739ENST00000341322-15366_4050121.0RepeatNote=WD 5
HgeneBRWD1chr21:40670358chr16:89713739ENST00000341322-15424_4630121.0RepeatNote=WD 6
HgeneBRWD1chr21:40670358chr16:89713739ENST00000341322-15466_5060121.0RepeatNote=WD 7
HgeneBRWD1chr21:40670358chr16:89713739ENST00000341322-15514_5530121.0RepeatNote=WD 8
HgeneBRWD1chr21:40670358chr16:89713739ENST00000342449-541184_2231162270.0RepeatNote=WD 1
HgeneBRWD1chr21:40670358chr16:89713739ENST00000342449-541226_2651162270.0RepeatNote=WD 2
HgeneBRWD1chr21:40670358chr16:89713739ENST00000342449-541268_3111162270.0RepeatNote=WD 3
HgeneBRWD1chr21:40670358chr16:89713739ENST00000342449-541322_3651162270.0RepeatNote=WD 4
HgeneBRWD1chr21:40670358chr16:89713739ENST00000342449-541366_4051162270.0RepeatNote=WD 5
HgeneBRWD1chr21:40670358chr16:89713739ENST00000342449-541424_4631162270.0RepeatNote=WD 6
HgeneBRWD1chr21:40670358chr16:89713739ENST00000342449-541466_5061162270.0RepeatNote=WD 7
HgeneBRWD1chr21:40670358chr16:89713739ENST00000342449-541514_5531162270.0RepeatNote=WD 8
HgeneBRWD1chr21:40670358chr16:89713739ENST00000380800-542184_2231162200.0RepeatNote=WD 1
HgeneBRWD1chr21:40670358chr16:89713739ENST00000380800-542226_2651162200.0RepeatNote=WD 2
HgeneBRWD1chr21:40670358chr16:89713739ENST00000380800-542268_3111162200.0RepeatNote=WD 3
HgeneBRWD1chr21:40670358chr16:89713739ENST00000380800-542322_3651162200.0RepeatNote=WD 4
HgeneBRWD1chr21:40670358chr16:89713739ENST00000380800-542366_4051162200.0RepeatNote=WD 5
HgeneBRWD1chr21:40670358chr16:89713739ENST00000380800-542424_4631162200.0RepeatNote=WD 6
HgeneBRWD1chr21:40670358chr16:89713739ENST00000380800-542466_5061162200.0RepeatNote=WD 7
HgeneBRWD1chr21:40670358chr16:89713739ENST00000380800-542514_5531162200.0RepeatNote=WD 8
TgeneCHMP1Achr21:40670358chr16:89713739ENST00000397901375_4784197.0Coiled coilOntology_term=ECO:0000255


Top

Fusion Gene Sequence for BRWD1-CHMP1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10340_10340_1_BRWD1-CHMP1A_BRWD1_chr21_40670358_ENST00000333229_CHMP1A_chr16_89713739_ENST00000253475_length(transcript)=2644nt_BP=677nt
AGGTCTTTGCCTCCGCGTCACTTTCTCCTCATCGAGTCCCCGGAGGCAGAGAGCTGAGCGAGGTTCGCCTCCCCGGGCGGGACACGAGCT
CCGGTCCTCTCTTGGCGCAAACCCCCGCCCCCCGCGGAGGGACTACTTTTCGTCTCCCGCGGAGGAACTACTTCCTCCCCCGCGGAGGCG
TCGGTCCAGGCGGCGCGCACGGTATGGCGGCGGCGGCGGCGGCGGCGGCGCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCG
GCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCGCGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGT
GCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCGGCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGA
GCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAACGAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAA
GCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCTATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCAC
TTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGGTGACCAAGAATATGGCCCAGGTGACCAAAGCCCTGGACAAGG
CCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGACGTCCATACATCGGTGA
TGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGATCGCCGAGGAGAATGGCC
TGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCAGGAGGACCAGCTGTCAC
GGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGTGCACCGCCTCTGCCCCGTGATGTGCTGGAAGGCTCCTGTCCTCTCCC
CACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCGGCAGCCACTCTGCGTCTCTCACCTGCCAGGCCTGCGTGGCCTTAGGG
TTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCTGTGTCCTGGTGTTGAGTTTCTGCAAATTTCTGGGGGTGATTTCTGTGACTCTGGGC
CCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGACTTTCACCCAGCACTGTGGGGGCCTTCAGACTCTGGGGCAGCAGACATGCTGCTTCC
CATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGCCAAACAACTCCCTGAGGCCTCTCCGCACCACCTCAGCGGGCAGGAGGTCCCACCAT
GTGGACAGACATAGCCCAAGGAGGCACCACAGGTCTATGTGTGCTGGGGGATGTCAGGTGCCACCCAACGCTGTCCTGGTGGTATTTACA
ATGACATCCTCCTCCTCCATCACTCCAGGGGTGGTGTCTCGGCCGCCCCTACCAGCTGGCTGAGCCCCCTGGCCTCCTGCGCTCCCTCAC
TTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGGGACAGAACCGTCACTCAGATCCACATTCAAGTGTGCCCACCCTGCAGTCTTCATCC
TCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGCCACATGTGCTGTGCTGTTTGTCTCCTCGACAGGGAGCCTGTCCACCAGCAGGCTGC
GGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTTGGGCAGCCTGGTTCTCCCGGAGGACCTTTCCTTGGGGCCCTGCTTCATGACGATGC
TGCCTGTGTCACCCTCTACCATCTGTAAACAACTGGGTGCCTTCCCCGACCACACCCCAATGCCTTCCCAGCTTGGAAGCCAAGGCAGCT
GATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTGGGCTGGGGTTGGGGCTGCTGTGAGGAAAACCTGCCATTGTGGCCCTGGAGAGTCAC
CAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTGAGAGAGGCTTTGGGCACAGCCTGCTGTCTTTTCCATTTCCTAAAGTTTACTTCATT
GTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTGCCAAAGTAGAAAAGGCAGGTGGTGGGCGGCTGGCAGGGAGTGCGGGTCCCCGCCCC
TCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCCCACCCCGTGCAGCCCATGCTGAGGCTGCAGTGGTGTCGTGGGTGTTACGTGCAGGA
ACGTGGAGACCCTGACGTGGGCTCACTGCGTTTGGTTTTCTTTTCAGAACTTGGGAGCCCCCAGGGAGGGGCTAGTGTTGGTAGGTCCTA
GACGTGGTTCCCTCCAGCCTCCCCAAAATCAACCCTGGTGTTGAGAGAACGTCCTTCTGTCCATCGTGGGTAACAGCCTTGGGGAGGGTG
CAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCTGCCTCAGTCCTGTCCCCTTGGGCACTGAGGAGAGGGGCCCATTCACCTTTCTCCTA

>10340_10340_1_BRWD1-CHMP1A_BRWD1_chr21_40670358_ENST00000333229_CHMP1A_chr16_89713739_ENST00000253475_length(amino acids)=310AA_BP=147
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKGDQEYGPGDQSPGQGPEHHGPAEGLLSDGQVRA
AGAEPGRPYIGDGGLHELGHHPDHAAGAGGQPHHADRRGEWPGGAGPAQPAARGRLCRGRELCAQPGGPAVTEVGRLEELAVPRRCAPPL

--------------------------------------------------------------
>10340_10340_2_BRWD1-CHMP1A_BRWD1_chr21_40670358_ENST00000342449_CHMP1A_chr16_89713739_ENST00000253475_length(transcript)=2395nt_BP=428nt
CGCCAGCCCGGTCAGGCCTCGGCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCGCGCCCGGCCATGGCGGAGCC
GTCGTCCGCCCGACGCCCGGTGCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCGGCGGGCCCGTGTCGGAGAGC
GGCCCAGGTGCTGGTGCAGGAGCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAACGAGCACAACAGGAGCTACGA
GGAGTTGGTCTTGTCCAATAAGCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCTATGTTGGATAAAGAAATTCC
ACCCAGTATTTCAAGAGTCACTTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGGTGACCAAGAATATGGCCCAGG
TGACCAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACC
TGGACGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCATGC
AGATCGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCA
GCCAGGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGTGCACCGCCTCTGCCCCGTGATGTGCT
GGAAGGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCGGCAGCCACTCTGCGTCTCTCACCTGC
CAGGCCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCTGTGTCCTGGTGTTGAGTTTCTGCAAATTTCTGGGG
GTGATTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGACTTTCACCCAGCACTGTGGGGGCCTTCAGACTCTGG
GGCAGCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGCCAAACAACTCCCTGAGGCCTCTCCGCACCACCTCA
GCGGGCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGTCTATGTGTGCTGGGGGATGTCAGGTGCCACCCAAC
GCTGTCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGGTGTCTCGGCCGCCCCTACCAGCTGGCTGAGCCCCC
TGGCCTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGGGACAGAACCGTCACTCAGATCCACATTCAAGTGTG
CCCACCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGCCACATGTGCTGTGCTGTTTGTCTCCTCGACAGGGA
GCCTGTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTTGGGCAGCCTGGTTCTCCCGGAGGACCTTTCCTTGG
GGCCCTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACTGGGTGCCTTCCCCGACCACACCCCAATGCCTTCCC
AGCTTGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTGGGCTGGGGTTGGGGCTGCTGTGAGGAAAACCTGCC
ATTGTGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTGAGAGAGGCTTTGGGCACAGCCTGCTGTCTTTTCCA
TTTCCTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTGCCAAAGTAGAAAAGGCAGGTGGTGGGCGGCTGGCA
GGGAGTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCCCACCCCGTGCAGCCCATGCTGAGGCTGCAGTGGTG
TCGTGGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTGGTTTTCTTTTCAGAACTTGGGAGCCCCCAGGGAGG
GGCTAGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACCCTGGTGTTGAGAGAACGTCCTTCTGTCCATCGTGG
GTAACAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCTGCCTCAGTCCTGTCCCCTTGGGCACTGAGGAGAGG

>10340_10340_2_BRWD1-CHMP1A_BRWD1_chr21_40670358_ENST00000342449_CHMP1A_chr16_89713739_ENST00000253475_length(amino acids)=279AA_BP=116
MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLD
KEIPPSISRVTSLLGAGRQSLLRTAKGDQEYGPGDQSPGQGPEHHGPAEGLLSDGQVRAAGAEPGRPYIGDGGLHELGHHPDHAAGAGGQ
PHHADRRGEWPGGAGPAQPAARGRLCRGRELCAQPGGPAVTEVGRLEELAVPRRCAPPLPRDVLEGSCPLPTASCLCADPAGLRPAATLR

--------------------------------------------------------------
>10340_10340_3_BRWD1-CHMP1A_BRWD1_chr21_40670358_ENST00000380800_CHMP1A_chr16_89713739_ENST00000253475_length(transcript)=2415nt_BP=448nt
GCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCGGCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCG
CGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGTGCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCG
GCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGAGCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAAC
GAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAAGCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCT
ATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCACTTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGGT
GACCAAGAATATGGCCCAGGTGACCAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTT
CGAGCAGCAGGTGCAGAACCTGGACGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCA
GGTGGACAGCCTCATCATGCAGATCGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGT
GGGCGAGAGCTCTGTGCGCAGCCAGGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGTGCACCG
CCTCTGCCCCGTGATGTGCTGGAAGGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCGGCAGCC
ACTCTGCGTCTCTCACCTGCCAGGCCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCTGTGTCCTGGTGTTGA
GTTTCTGCAAATTTCTGGGGGTGATTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGACTTTCACCCAGCACTG
TGGGGGCCTTCAGACTCTGGGGCAGCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGCCAAACAACTCCCTGA
GGCCTCTCCGCACCACCTCAGCGGGCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGTCTATGTGTGCTGGGG
GATGTCAGGTGCCACCCAACGCTGTCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGGTGTCTCGGCCGCCCC
TACCAGCTGGCTGAGCCCCCTGGCCTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGGGACAGAACCGTCACT
CAGATCCACATTCAAGTGTGCCCACCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGCCACATGTGCTGTGCT
GTTTGTCTCCTCGACAGGGAGCCTGTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTTGGGCAGCCTGGTTCT
CCCGGAGGACCTTTCCTTGGGGCCCTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACTGGGTGCCTTCCCCGA
CCACACCCCAATGCCTTCCCAGCTTGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTGGGCTGGGGTTGGGGC
TGCTGTGAGGAAAACCTGCCATTGTGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTGAGAGAGGCTTTGGGC
ACAGCCTGCTGTCTTTTCCATTTCCTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTGCCAAAGTAGAAAAGG
CAGGTGGTGGGCGGCTGGCAGGGAGTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCCCACCCCGTGCAGCCC
ATGCTGAGGCTGCAGTGGTGTCGTGGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTGGTTTTCTTTTCAGAA
CTTGGGAGCCCCCAGGGAGGGGCTAGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACCCTGGTGTTGAGAGAA
CGTCCTTCTGTCCATCGTGGGTAACAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCTGCCTCAGTCCTGTCC

>10340_10340_3_BRWD1-CHMP1A_BRWD1_chr21_40670358_ENST00000380800_CHMP1A_chr16_89713739_ENST00000253475_length(amino acids)=310AA_BP=147
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKGDQEYGPGDQSPGQGPEHHGPAEGLLSDGQVRA
AGAEPGRPYIGDGGLHELGHHPDHAAGAGGQPHHADRRGEWPGGAGPAQPAARGRLCRGRELCAQPGGPAVTEVGRLEELAVPRRCAPPL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for BRWD1-CHMP1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for BRWD1-CHMP1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for BRWD1-CHMP1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRWD1C0028960Oligospermia1CTD_human
TgeneC0266468Congenital pontocerebellar hypoplasia1GENOMICS_ENGLAND
TgeneC3554209Congenital pontocerebellar hypoplasia type 81CTD_human;GENOMICS_ENGLAND;ORPHANET