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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRWD1-EZR (FusionGDB2 ID:HG54014TG7430)

Fusion Gene Summary for BRWD1-EZR

check button Fusion gene summary
Fusion gene informationFusion gene name: BRWD1-EZR
Fusion gene ID: hg54014tg7430
HgeneTgene
Gene symbol

BRWD1

EZR

Gene ID

54014

7430

Gene namebromodomain and WD repeat domain containing 1ezrin
SynonymsC21orf107|DCAF19|N143|WDR9|WRD9CVIL|CVL|HEL-S-105|VIL2
Cytomap('BRWD1')('EZR')

21q22.2

6q25.3

Type of geneprotein-codingprotein-coding
Descriptionbromodomain and WD repeat-containing protein 1WD repeat protein WDR9-form2WD repeat-containing protein 9transcriptional unit N143ezrincytovillin 2epididymis secretory protein Li 105p81villin 2 (ezrin)
Modification date2020031320200322
UniProtAcc.

P15311

Ensembl transtripts involved in fusion geneENST00000333229, ENST00000342449, 
ENST00000380800, ENST00000341322, 
ENST00000470108, 
Fusion gene scores* DoF score28 X 28 X 10=784025 X 24 X 6=3600
# samples 3227
** MAII scorelog2(32/7840*10)=-4.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/3600*10)=-3.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRWD1 [Title/Abstract] AND EZR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRWD1(40622722)-EZR(159192439), # samples:1
Anticipated loss of major functional domain due to fusion event.BRWD1-EZR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRWD1-EZR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRWD1-EZR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BRWD1-EZR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEZR

GO:0048015

phosphatidylinositol-mediated signaling

25591774

TgeneEZR

GO:0051017

actin filament bundle assembly

10793131


check buttonFusion gene breakpoints across BRWD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across EZR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8078-01ABRWD1chr21

40622722

-EZRchr6

159192439

-


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Fusion Gene ORF analysis for BRWD1-EZR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000333229ENST00000476189BRWD1chr21

40622722

-EZRchr6

159192439

-
5CDS-intronENST00000342449ENST00000476189BRWD1chr21

40622722

-EZRchr6

159192439

-
5CDS-intronENST00000380800ENST00000476189BRWD1chr21

40622722

-EZRchr6

159192439

-
In-frameENST00000333229ENST00000337147BRWD1chr21

40622722

-EZRchr6

159192439

-
In-frameENST00000333229ENST00000367075BRWD1chr21

40622722

-EZRchr6

159192439

-
In-frameENST00000333229ENST00000392177BRWD1chr21

40622722

-EZRchr6

159192439

-
In-frameENST00000342449ENST00000337147BRWD1chr21

40622722

-EZRchr6

159192439

-
In-frameENST00000342449ENST00000367075BRWD1chr21

40622722

-EZRchr6

159192439

-
In-frameENST00000342449ENST00000392177BRWD1chr21

40622722

-EZRchr6

159192439

-
In-frameENST00000380800ENST00000337147BRWD1chr21

40622722

-EZRchr6

159192439

-
In-frameENST00000380800ENST00000367075BRWD1chr21

40622722

-EZRchr6

159192439

-
In-frameENST00000380800ENST00000392177BRWD1chr21

40622722

-EZRchr6

159192439

-
intron-3CDSENST00000341322ENST00000337147BRWD1chr21

40622722

-EZRchr6

159192439

-
intron-3CDSENST00000341322ENST00000367075BRWD1chr21

40622722

-EZRchr6

159192439

-
intron-3CDSENST00000341322ENST00000392177BRWD1chr21

40622722

-EZRchr6

159192439

-
intron-3CDSENST00000470108ENST00000337147BRWD1chr21

40622722

-EZRchr6

159192439

-
intron-3CDSENST00000470108ENST00000367075BRWD1chr21

40622722

-EZRchr6

159192439

-
intron-3CDSENST00000470108ENST00000392177BRWD1chr21

40622722

-EZRchr6

159192439

-
intron-intronENST00000341322ENST00000476189BRWD1chr21

40622722

-EZRchr6

159192439

-
intron-intronENST00000470108ENST00000476189BRWD1chr21

40622722

-EZRchr6

159192439

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000333229BRWD1chr2140622722-ENST00000337147EZRchr6159192439-4816267723536421135
ENST00000333229BRWD1chr2140622722-ENST00000367075EZRchr6159192439-4809267723536421135
ENST00000333229BRWD1chr2140622722-ENST00000392177EZRchr6159192439-3661267723536421135
ENST00000342449BRWD1chr2140622722-ENST00000337147EZRchr6159192439-456724287933931104
ENST00000342449BRWD1chr2140622722-ENST00000367075EZRchr6159192439-456024287933931104
ENST00000342449BRWD1chr2140622722-ENST00000392177EZRchr6159192439-341224287933931104
ENST00000380800BRWD1chr2140622722-ENST00000337147EZRchr6159192439-45872448634131135
ENST00000380800BRWD1chr2140622722-ENST00000367075EZRchr6159192439-45802448634131135
ENST00000380800BRWD1chr2140622722-ENST00000392177EZRchr6159192439-34322448634131135

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000333229ENST00000337147BRWD1chr2140622722-EZRchr6159192439-0.0019525680.9980475
ENST00000333229ENST00000367075BRWD1chr2140622722-EZRchr6159192439-0.0019123170.9980877
ENST00000333229ENST00000392177BRWD1chr2140622722-EZRchr6159192439-0.0042061480.9957938
ENST00000342449ENST00000337147BRWD1chr2140622722-EZRchr6159192439-0.0016088330.9983911
ENST00000342449ENST00000367075BRWD1chr2140622722-EZRchr6159192439-0.0015734710.99842656
ENST00000342449ENST00000392177BRWD1chr2140622722-EZRchr6159192439-0.0035736170.9964264
ENST00000380800ENST00000337147BRWD1chr2140622722-EZRchr6159192439-0.0016138760.99838614
ENST00000380800ENST00000367075BRWD1chr2140622722-EZRchr6159192439-0.0015776860.99842227
ENST00000380800ENST00000392177BRWD1chr2140622722-EZRchr6159192439-0.003497810.99650216

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Fusion Genomic Features for BRWD1-EZR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BRWD1-EZR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:40622722/chr6:159192439)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EZR

P15311

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRWD1chr21:40622722chr6:159192439ENST00000333229-2042661_6687832321.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40622722chr6:159192439ENST00000342449-2041661_6687832270.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40622722chr6:159192439ENST00000380800-2042661_6687832200.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40622722chr6:159192439ENST00000333229-2042184_2237832321.0RepeatNote=WD 1
HgeneBRWD1chr21:40622722chr6:159192439ENST00000333229-2042226_2657832321.0RepeatNote=WD 2
HgeneBRWD1chr21:40622722chr6:159192439ENST00000333229-2042268_3117832321.0RepeatNote=WD 3
HgeneBRWD1chr21:40622722chr6:159192439ENST00000333229-2042322_3657832321.0RepeatNote=WD 4
HgeneBRWD1chr21:40622722chr6:159192439ENST00000333229-2042366_4057832321.0RepeatNote=WD 5
HgeneBRWD1chr21:40622722chr6:159192439ENST00000333229-2042424_4637832321.0RepeatNote=WD 6
HgeneBRWD1chr21:40622722chr6:159192439ENST00000333229-2042466_5067832321.0RepeatNote=WD 7
HgeneBRWD1chr21:40622722chr6:159192439ENST00000333229-2042514_5537832321.0RepeatNote=WD 8
HgeneBRWD1chr21:40622722chr6:159192439ENST00000342449-2041184_2237832270.0RepeatNote=WD 1
HgeneBRWD1chr21:40622722chr6:159192439ENST00000342449-2041226_2657832270.0RepeatNote=WD 2
HgeneBRWD1chr21:40622722chr6:159192439ENST00000342449-2041268_3117832270.0RepeatNote=WD 3
HgeneBRWD1chr21:40622722chr6:159192439ENST00000342449-2041322_3657832270.0RepeatNote=WD 4
HgeneBRWD1chr21:40622722chr6:159192439ENST00000342449-2041366_4057832270.0RepeatNote=WD 5
HgeneBRWD1chr21:40622722chr6:159192439ENST00000342449-2041424_4637832270.0RepeatNote=WD 6
HgeneBRWD1chr21:40622722chr6:159192439ENST00000342449-2041466_5067832270.0RepeatNote=WD 7
HgeneBRWD1chr21:40622722chr6:159192439ENST00000342449-2041514_5537832270.0RepeatNote=WD 8
HgeneBRWD1chr21:40622722chr6:159192439ENST00000380800-2042184_2237832200.0RepeatNote=WD 1
HgeneBRWD1chr21:40622722chr6:159192439ENST00000380800-2042226_2657832200.0RepeatNote=WD 2
HgeneBRWD1chr21:40622722chr6:159192439ENST00000380800-2042268_3117832200.0RepeatNote=WD 3
HgeneBRWD1chr21:40622722chr6:159192439ENST00000380800-2042322_3657832200.0RepeatNote=WD 4
HgeneBRWD1chr21:40622722chr6:159192439ENST00000380800-2042366_4057832200.0RepeatNote=WD 5
HgeneBRWD1chr21:40622722chr6:159192439ENST00000380800-2042424_4637832200.0RepeatNote=WD 6
HgeneBRWD1chr21:40622722chr6:159192439ENST00000380800-2042466_5067832200.0RepeatNote=WD 7
HgeneBRWD1chr21:40622722chr6:159192439ENST00000380800-2042514_5537832200.0RepeatNote=WD 8

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRWD1chr21:40622722chr6:159192439ENST00000333229-20421539_15487832321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40622722chr6:159192439ENST00000333229-20421687_16927832321.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40622722chr6:159192439ENST00000333229-2042821_8247832321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40622722chr6:159192439ENST00000341322-151539_15480121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40622722chr6:159192439ENST00000341322-151687_16920121.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40622722chr6:159192439ENST00000341322-15661_6680121.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40622722chr6:159192439ENST00000341322-15821_8240121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40622722chr6:159192439ENST00000342449-20411539_15487832270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40622722chr6:159192439ENST00000342449-20411687_16927832270.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40622722chr6:159192439ENST00000342449-2041821_8247832270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40622722chr6:159192439ENST00000380800-20421539_15487832200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40622722chr6:159192439ENST00000380800-20421687_16927832200.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40622722chr6:159192439ENST00000380800-2042821_8247832200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40622722chr6:159192439ENST00000333229-20421177_12477832321.0DomainBromo 1
HgeneBRWD1chr21:40622722chr6:159192439ENST00000333229-20421330_14007832321.0DomainBromo 2
HgeneBRWD1chr21:40622722chr6:159192439ENST00000341322-151177_12470121.0DomainBromo 1
HgeneBRWD1chr21:40622722chr6:159192439ENST00000341322-151330_14000121.0DomainBromo 2
HgeneBRWD1chr21:40622722chr6:159192439ENST00000342449-20411177_12477832270.0DomainBromo 1
HgeneBRWD1chr21:40622722chr6:159192439ENST00000342449-20411330_14007832270.0DomainBromo 2
HgeneBRWD1chr21:40622722chr6:159192439ENST00000380800-20421177_12477832200.0DomainBromo 1
HgeneBRWD1chr21:40622722chr6:159192439ENST00000380800-20421330_14007832200.0DomainBromo 2
HgeneBRWD1chr21:40622722chr6:159192439ENST00000341322-15184_2230121.0RepeatNote=WD 1
HgeneBRWD1chr21:40622722chr6:159192439ENST00000341322-15226_2650121.0RepeatNote=WD 2
HgeneBRWD1chr21:40622722chr6:159192439ENST00000341322-15268_3110121.0RepeatNote=WD 3
HgeneBRWD1chr21:40622722chr6:159192439ENST00000341322-15322_3650121.0RepeatNote=WD 4
HgeneBRWD1chr21:40622722chr6:159192439ENST00000341322-15366_4050121.0RepeatNote=WD 5
HgeneBRWD1chr21:40622722chr6:159192439ENST00000341322-15424_4630121.0RepeatNote=WD 6
HgeneBRWD1chr21:40622722chr6:159192439ENST00000341322-15466_5060121.0RepeatNote=WD 7
HgeneBRWD1chr21:40622722chr6:159192439ENST00000341322-15514_5530121.0RepeatNote=WD 8
TgeneEZRchr21:40622722chr6:159192439ENST000003371476132_295265587.0DomainFERM
TgeneEZRchr21:40622722chr6:159192439ENST000003670757142_295265587.0DomainFERM
TgeneEZRchr21:40622722chr6:159192439ENST00000337147613115_120265587.0Motif[IL]-x-C-x-x-[DE] motif
TgeneEZRchr21:40622722chr6:159192439ENST00000367075714115_120265587.0Motif[IL]-x-C-x-x-[DE] motif


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Fusion Gene Sequence for BRWD1-EZR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10344_10344_1_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000333229_EZR_chr6_159192439_ENST00000337147_length(transcript)=4816nt_BP=2677nt
AGGTCTTTGCCTCCGCGTCACTTTCTCCTCATCGAGTCCCCGGAGGCAGAGAGCTGAGCGAGGTTCGCCTCCCCGGGCGGGACACGAGCT
CCGGTCCTCTCTTGGCGCAAACCCCCGCCCCCCGCGGAGGGACTACTTTTCGTCTCCCGCGGAGGAACTACTTCCTCCCCCGCGGAGGCG
TCGGTCCAGGCGGCGCGCACGGTATGGCGGCGGCGGCGGCGGCGGCGGCGCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCG
GCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCGCGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGT
GCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCGGCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGA
GCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAACGAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAA
GCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCTATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCAC
TTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGACTGCAGGCACACAGTTTGGAAGGGCTCTGCCTTTGCTGCTCT
TCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCAAATCTTGTGGAGATACATCGAGGAAAACAACTCACAGGGTG
TTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAAATGCACAGAAGGATTCTCGGACATCTATCTGCTGTTTACTG
TGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGACTGTTTGGTAAAGATTTGGTCAACACATAATGGCCGCTTGTT
ATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAACTATGAGAATACAATGATTGCTGCGGGGAGCTGTGATAAAAT
TATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAAGGACACACAGGATCAATTACATCTTTACAGTTTAGCCCGAT
GGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACAGTTTGCTTTTGGCAATGGGATTTAGAATCCTTAAAATTTAG
CCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATGCTTTGTTCTTCTTTTAGTGTTGGTGGTATGTTTTTAGCCAC
AGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCACCCGAAAAAATCGCAGAACTTGAAAGCCACACTGATAAAGT
AGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGCAGAGATGGAACAGCACGGATTTGGAGATTTGAGCAGTTAGA
ATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTATCTTCCGAAGAGGAAAGGTTTATGAAACCTAAAGTAACAAT
GATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGATCATGTCCTCAAAGTGTGGAATTCTTACACTGGACAACTGCT
TCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACATCCCTTTGATTCCAGAATTATGTTATCTGCAGGACATGATGG
CAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTATTTTAATATGATTGAAGGACAAGGACATGGAGCTGTGTTTGA
CTGTAAGTTTTCACAGGATGGACAGCATTTTGCCTGTACAGATTCTCATGGGCACCTTCTGATATTTGGTTTTGGATGCAGCAAACCATA
TGAAAAGATTCCTGATCAGATGTTCTTCCATACTGACTATCGACCACTTATTAGAGATTCTAATAATTATGTCTTAGATGAGCAAACTCA
GCAGGCTCCTCATCTTATGCCTCCACCATTCTTGGTAGATGTAGATGGAAATCCTCATCCAACCAAGTATCAGAGATTAGTACCAGGCCG
AGAAAATTCTGCAGATGAACATTTGATTCCACAGCTGGGCTATGTGGCAACAAGTGATGGAGAGGTGATTGAACAAATTATAAGCCTGCA
AACCAATGATAATGATGAACGCAGCCCAGAATCGAGTATTCTTGATGGAATGATAAGACAGTTGCAGCAGCAGCAAGATCAGAGAATGGG
AGCAGATCAGGATACTATTCCAAGAGGACTTTCAAATGGTGAAGAAACACCCCGGAGAGGTTTTAGAAGGCTGAGCTTAGACATTCAGTC
CCCTCCAAATATTGGTCTGCGTCGTAGTGGACAAGTTGAAGGTGTTCGTCAGATGCATCAAAACGCTCCACGCAGTCAGATTGCTACAGA
ACGTGACCTGCAGGCTTGGAAACGAAGAGTGGTTGTACCAGAGGTACCACTAGGCATATTTAGGAAGCTGGAAGACTTCCGATTAGAGAA
AGGTGAAGAGGAAAGAAATCTTTATATAATAGGAAGAAAAAGAAAGACTCTTCAGCTCTCACATAAGGACTTTGTGTTTTATGCCCCACG
TCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGGGCAACCATGAGTTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCA
GCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAGCGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGT
GGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTGCGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAG
AGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGGAAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCG
TATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGATCAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGA
ATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAAGAGTGGCAGCACAGGGCCAAAGAAGCCCA
GGATGACCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGATGACAGCACCCCCGCCCCCACCACCCCCCGTGTACGAGCCGGTGAGCTA
CCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTACAGCGCGGAGCTGTCTAGTGAGGGCATCCGGGATGACCGCAA
TGAGGAGAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGGCAGCTGCTGACGCTGAGCAGCGAGCTGTCCCAGGCCCGAGA
TGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGGCAAGGCCGGGACAAGTACAAGACGCTGCGGCAGATCCGGCA
GGGCAACACCAAGCAGCGCATCGACGAGTTCGAGGCCCTGTAACAGCCAGGCCAGGACCAAGGGCAGAGGGGTGCTCATAGCGGGCGCTG
CCAGCCCCGCCACGCTTGTGTCTTTAGTGCTCCAAGTCTAGGAACTCCCTCAGATCCCAGTTCCTTTAGAAAGCAGTTACCCAACAGAAA
CATTCTGGGCTGGGAACCAGGGAGGCGCCCTGGTTTGTTTTCCCCAGTTGTAATAGTGCCAAGCAGGCCTGATTCTCGCGATTATTCTCG
AATCACCTCCTGTGTTGTGCTGGGAGCAGGACTGATTGAATTACGGAAAATGCCTGTAAAGTCTGAGTAAGAAACTTCATGCTGGCCTGT
GTGATACAAGAGTCAGCATCATTAAAGGAAACGTGGCAGGACTTCCATCTGTGCCATACTTGTTCTGTATTCGAAATGAGCTCAAATTGA
TTTTTTAATTTCTATGAAGGATCCATCTTTGTATATTTACATGCTTAGAGGGGTGAAAATTATTTTGGAAATTGAGTCTGAAGCACTCTC
GCACACACAGTGATTCCCTCCTCCCGTCACTCCACGCAGCTGGCAGAGAGCACAGTGATCACCAGCGTGAGTGGTGGAGGAGGACACTTG
GATTTTTTTTTTTGTTTTTTTTTTTTTTGCTTAACAGTTTTAGAATACATTGTACTTATACACCTTATTAATGATCAGCTATATACTATT
TATATACAAGTGATAATACAGATTTGTAACATTAGTTTTAAAAAGGGAAAGTTTTGTTCTGTATATTTTGTTACCTTTTACAGAATAAAA
GAATTACATATGAAAAACCCTCTAAACCATGGCACTTGATGTGATGTGGCAGGAGGGCAGTGGTGGAGCTGGACCTGCCTGCTGCAGTCA
CGTGTAAACAGGATTATTATTAGTGTTTTATGCATGTAATGGACTATGCACACTTTTAATTTTGTCAGATTCACACATGCCACTATGAGC
TTTCAGACTCCAGCTGTGAAGAGACTCTGTTTGCTTGTGTTTGTTTGTTTGCAGTCTCTCTCTGCCATGGCCTTGGCAGGCTGCTGGAAG
GCAGCTTGTGGAGGCCGTTGGTTCCGCCCACTCATTCCTTCTCGTGCACTGCTTTCTCCTTCACAGCTAAGATGCCATGTGCAGGTGGAT

>10344_10344_1_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000333229_EZR_chr6_159192439_ENST00000337147_length(amino acids)=1135AA_BP=814
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN
MIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNP
HPTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRMGADQDTIPRGLSNGEETPR
RGFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQ
LSHKDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRL
QDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDE
VEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQL

--------------------------------------------------------------
>10344_10344_2_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000333229_EZR_chr6_159192439_ENST00000367075_length(transcript)=4809nt_BP=2677nt
AGGTCTTTGCCTCCGCGTCACTTTCTCCTCATCGAGTCCCCGGAGGCAGAGAGCTGAGCGAGGTTCGCCTCCCCGGGCGGGACACGAGCT
CCGGTCCTCTCTTGGCGCAAACCCCCGCCCCCCGCGGAGGGACTACTTTTCGTCTCCCGCGGAGGAACTACTTCCTCCCCCGCGGAGGCG
TCGGTCCAGGCGGCGCGCACGGTATGGCGGCGGCGGCGGCGGCGGCGGCGCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCG
GCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCGCGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGT
GCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCGGCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGA
GCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAACGAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAA
GCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCTATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCAC
TTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGACTGCAGGCACACAGTTTGGAAGGGCTCTGCCTTTGCTGCTCT
TCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCAAATCTTGTGGAGATACATCGAGGAAAACAACTCACAGGGTG
TTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAAATGCACAGAAGGATTCTCGGACATCTATCTGCTGTTTACTG
TGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGACTGTTTGGTAAAGATTTGGTCAACACATAATGGCCGCTTGTT
ATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAACTATGAGAATACAATGATTGCTGCGGGGAGCTGTGATAAAAT
TATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAAGGACACACAGGATCAATTACATCTTTACAGTTTAGCCCGAT
GGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACAGTTTGCTTTTGGCAATGGGATTTAGAATCCTTAAAATTTAG
CCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATGCTTTGTTCTTCTTTTAGTGTTGGTGGTATGTTTTTAGCCAC
AGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCACCCGAAAAAATCGCAGAACTTGAAAGCCACACTGATAAAGT
AGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGCAGAGATGGAACAGCACGGATTTGGAGATTTGAGCAGTTAGA
ATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTATCTTCCGAAGAGGAAAGGTTTATGAAACCTAAAGTAACAAT
GATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGATCATGTCCTCAAAGTGTGGAATTCTTACACTGGACAACTGCT
TCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACATCCCTTTGATTCCAGAATTATGTTATCTGCAGGACATGATGG
CAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTATTTTAATATGATTGAAGGACAAGGACATGGAGCTGTGTTTGA
CTGTAAGTTTTCACAGGATGGACAGCATTTTGCCTGTACAGATTCTCATGGGCACCTTCTGATATTTGGTTTTGGATGCAGCAAACCATA
TGAAAAGATTCCTGATCAGATGTTCTTCCATACTGACTATCGACCACTTATTAGAGATTCTAATAATTATGTCTTAGATGAGCAAACTCA
GCAGGCTCCTCATCTTATGCCTCCACCATTCTTGGTAGATGTAGATGGAAATCCTCATCCAACCAAGTATCAGAGATTAGTACCAGGCCG
AGAAAATTCTGCAGATGAACATTTGATTCCACAGCTGGGCTATGTGGCAACAAGTGATGGAGAGGTGATTGAACAAATTATAAGCCTGCA
AACCAATGATAATGATGAACGCAGCCCAGAATCGAGTATTCTTGATGGAATGATAAGACAGTTGCAGCAGCAGCAAGATCAGAGAATGGG
AGCAGATCAGGATACTATTCCAAGAGGACTTTCAAATGGTGAAGAAACACCCCGGAGAGGTTTTAGAAGGCTGAGCTTAGACATTCAGTC
CCCTCCAAATATTGGTCTGCGTCGTAGTGGACAAGTTGAAGGTGTTCGTCAGATGCATCAAAACGCTCCACGCAGTCAGATTGCTACAGA
ACGTGACCTGCAGGCTTGGAAACGAAGAGTGGTTGTACCAGAGGTACCACTAGGCATATTTAGGAAGCTGGAAGACTTCCGATTAGAGAA
AGGTGAAGAGGAAAGAAATCTTTATATAATAGGAAGAAAAAGAAAGACTCTTCAGCTCTCACATAAGGACTTTGTGTTTTATGCCCCACG
TCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGGGCAACCATGAGTTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCA
GCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAGCGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGT
GGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTGCGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAG
AGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGGAAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCG
TATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGATCAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGA
ATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAAGAGTGGCAGCACAGGGCCAAAGAAGCCCA
GGATGACCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGATGACAGCACCCCCGCCCCCACCACCCCCCGTGTACGAGCCGGTGAGCTA
CCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTACAGCGCGGAGCTGTCTAGTGAGGGCATCCGGGATGACCGCAA
TGAGGAGAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGGCAGCTGCTGACGCTGAGCAGCGAGCTGTCCCAGGCCCGAGA
TGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGGCAAGGCCGGGACAAGTACAAGACGCTGCGGCAGATCCGGCA
GGGCAACACCAAGCAGCGCATCGACGAGTTCGAGGCCCTGTAACAGCCAGGCCAGGACCAAGGGCAGAGGGGTGCTCATAGCGGGCGCTG
CCAGCCCCGCCACGCTTGTGTCTTTAGTGCTCCAAGTCTAGGAACTCCCTCAGATCCCAGTTCCTTTAGAAAGCAGTTACCCAACAGAAA
CATTCTGGGCTGGGAACCAGGGAGGCGCCCTGGTTTGTTTTCCCCAGTTGTAATAGTGCCAAGCAGGCCTGATTCTCGCGATTATTCTCG
AATCACCTCCTGTGTTGTGCTGGGAGCAGGACTGATTGAATTACGGAAAATGCCTGTAAAGTCTGAGTAAGAAACTTCATGCTGGCCTGT
GTGATACAAGAGTCAGCATCATTAAAGGAAACGTGGCAGGACTTCCATCTGTGCCATACTTGTTCTGTATTCGAAATGAGCTCAAATTGA
TTTTTTAATTTCTATGAAGGATCCATCTTTGTATATTTACATGCTTAGAGGGGTGAAAATTATTTTGGAAATTGAGTCTGAAGCACTCTC
GCACACACAGTGATTCCCTCCTCCCGTCACTCCACGCAGCTGGCAGAGAGCACAGTGATCACCAGCGTGAGTGGTGGAGGAGGACACTTG
GATTTTTTTTTTTGTTTTTTTTTTTTTTGCTTAACAGTTTTAGAATACATTGTACTTATACACCTTATTAATGATCAGCTATATACTATT
TATATACAAGTGATAATACAGATTTGTAACATTAGTTTTAAAAAGGGAAAGTTTTGTTCTGTATATTTTGTTACCTTTTACAGAATAAAA
GAATTACATATGAAAAACCCTCTAAACCATGGCACTTGATGTGATGTGGCAGGAGGGCAGTGGTGGAGCTGGACCTGCCTGCTGCAGTCA
CGTGTAAACAGGATTATTATTAGTGTTTTATGCATGTAATGGACTATGCACACTTTTAATTTTGTCAGATTCACACATGCCACTATGAGC
TTTCAGACTCCAGCTGTGAAGAGACTCTGTTTGCTTGTGTTTGTTTGTTTGCAGTCTCTCTCTGCCATGGCCTTGGCAGGCTGCTGGAAG
GCAGCTTGTGGAGGCCGTTGGTTCCGCCCACTCATTCCTTCTCGTGCACTGCTTTCTCCTTCACAGCTAAGATGCCATGTGCAGGTGGAT

>10344_10344_2_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000333229_EZR_chr6_159192439_ENST00000367075_length(amino acids)=1135AA_BP=814
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN
MIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNP
HPTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRMGADQDTIPRGLSNGEETPR
RGFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQ
LSHKDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRL
QDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDE
VEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQL

--------------------------------------------------------------
>10344_10344_3_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000333229_EZR_chr6_159192439_ENST00000392177_length(transcript)=3661nt_BP=2677nt
AGGTCTTTGCCTCCGCGTCACTTTCTCCTCATCGAGTCCCCGGAGGCAGAGAGCTGAGCGAGGTTCGCCTCCCCGGGCGGGACACGAGCT
CCGGTCCTCTCTTGGCGCAAACCCCCGCCCCCCGCGGAGGGACTACTTTTCGTCTCCCGCGGAGGAACTACTTCCTCCCCCGCGGAGGCG
TCGGTCCAGGCGGCGCGCACGGTATGGCGGCGGCGGCGGCGGCGGCGGCGCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCG
GCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCGCGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGT
GCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCGGCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGA
GCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAACGAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAA
GCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCTATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCAC
TTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGACTGCAGGCACACAGTTTGGAAGGGCTCTGCCTTTGCTGCTCT
TCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCAAATCTTGTGGAGATACATCGAGGAAAACAACTCACAGGGTG
TTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAAATGCACAGAAGGATTCTCGGACATCTATCTGCTGTTTACTG
TGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGACTGTTTGGTAAAGATTTGGTCAACACATAATGGCCGCTTGTT
ATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAACTATGAGAATACAATGATTGCTGCGGGGAGCTGTGATAAAAT
TATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAAGGACACACAGGATCAATTACATCTTTACAGTTTAGCCCGAT
GGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACAGTTTGCTTTTGGCAATGGGATTTAGAATCCTTAAAATTTAG
CCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATGCTTTGTTCTTCTTTTAGTGTTGGTGGTATGTTTTTAGCCAC
AGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCACCCGAAAAAATCGCAGAACTTGAAAGCCACACTGATAAAGT
AGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGCAGAGATGGAACAGCACGGATTTGGAGATTTGAGCAGTTAGA
ATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTATCTTCCGAAGAGGAAAGGTTTATGAAACCTAAAGTAACAAT
GATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGATCATGTCCTCAAAGTGTGGAATTCTTACACTGGACAACTGCT
TCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACATCCCTTTGATTCCAGAATTATGTTATCTGCAGGACATGATGG
CAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTATTTTAATATGATTGAAGGACAAGGACATGGAGCTGTGTTTGA
CTGTAAGTTTTCACAGGATGGACAGCATTTTGCCTGTACAGATTCTCATGGGCACCTTCTGATATTTGGTTTTGGATGCAGCAAACCATA
TGAAAAGATTCCTGATCAGATGTTCTTCCATACTGACTATCGACCACTTATTAGAGATTCTAATAATTATGTCTTAGATGAGCAAACTCA
GCAGGCTCCTCATCTTATGCCTCCACCATTCTTGGTAGATGTAGATGGAAATCCTCATCCAACCAAGTATCAGAGATTAGTACCAGGCCG
AGAAAATTCTGCAGATGAACATTTGATTCCACAGCTGGGCTATGTGGCAACAAGTGATGGAGAGGTGATTGAACAAATTATAAGCCTGCA
AACCAATGATAATGATGAACGCAGCCCAGAATCGAGTATTCTTGATGGAATGATAAGACAGTTGCAGCAGCAGCAAGATCAGAGAATGGG
AGCAGATCAGGATACTATTCCAAGAGGACTTTCAAATGGTGAAGAAACACCCCGGAGAGGTTTTAGAAGGCTGAGCTTAGACATTCAGTC
CCCTCCAAATATTGGTCTGCGTCGTAGTGGACAAGTTGAAGGTGTTCGTCAGATGCATCAAAACGCTCCACGCAGTCAGATTGCTACAGA
ACGTGACCTGCAGGCTTGGAAACGAAGAGTGGTTGTACCAGAGGTACCACTAGGCATATTTAGGAAGCTGGAAGACTTCCGATTAGAGAA
AGGTGAAGAGGAAAGAAATCTTTATATAATAGGAAGAAAAAGAAAGACTCTTCAGCTCTCACATAAGGACTTTGTGTTTTATGCCCCACG
TCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGGGCAACCATGAGTTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCA
GCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAGCGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGT
GGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTGCGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAG
AGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGGAAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCG
TATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGATCAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGA
ATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAAGAGTGGCAGCACAGGGCCAAAGAAGCCCA
GGATGACCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGATGACAGCACCCCCGCCCCCACCACCCCCCGTGTACGAGCCGGTGAGCTA
CCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTACAGCGCGGAGCTGTCTAGTGAGGGCATCCGGGATGACCGCAA
TGAGGAGAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGGCAGCTGCTGACGCTGAGCAGCGAGCTGTCCCAGGCCCGAGA
TGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGGCAAGGCCGGGACAAGTACAAGACGCTGCGGCAGATCCGGCA

>10344_10344_3_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000333229_EZR_chr6_159192439_ENST00000392177_length(amino acids)=1135AA_BP=814
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN
MIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNP
HPTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRMGADQDTIPRGLSNGEETPR
RGFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQ
LSHKDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRL
QDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDE
VEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQL

--------------------------------------------------------------
>10344_10344_4_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000342449_EZR_chr6_159192439_ENST00000337147_length(transcript)=4567nt_BP=2428nt
CGCCAGCCCGGTCAGGCCTCGGCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCGCGCCCGGCCATGGCGGAGCC
GTCGTCCGCCCGACGCCCGGTGCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCGGCGGGCCCGTGTCGGAGAGC
GGCCCAGGTGCTGGTGCAGGAGCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAACGAGCACAACAGGAGCTACGA
GGAGTTGGTCTTGTCCAATAAGCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCTATGTTGGATAAAGAAATTCC
ACCCAGTATTTCAAGAGTCACTTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGACTGCAGGCACACAGTTTGGAA
GGGCTCTGCCTTTGCTGCTCTTCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCAAATCTTGTGGAGATACATCG
AGGAAAACAACTCACAGGGTGTTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAAATGCACAGAAGGATTCTCGG
ACATCTATCTGCTGTTTACTGTGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGACTGTTTGGTAAAGATTTGGTC
AACACATAATGGCCGCTTGTTATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAACTATGAGAATACAATGATTGC
TGCGGGGAGCTGTGATAAAATTATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAAGGACACACAGGATCAATTAC
ATCTTTACAGTTTAGCCCGATGGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACAGTTTGCTTTTGGCAATGGGA
TTTAGAATCCTTAAAATTTAGCCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATGCTTTGTTCTTCTTTTAGTGT
TGGTGGTATGTTTTTAGCCACAGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCACCCGAAAAAATCGCAGAACT
TGAAAGCCACACTGATAAAGTAGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGCAGAGATGGAACAGCACGGAT
TTGGAGATTTGAGCAGTTAGAATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTATCTTCCGAAGAGGAAAGGTT
TATGAAACCTAAAGTAACAATGATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGATCATGTCCTCAAAGTGTGGAA
TTCTTACACTGGACAACTGCTTCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACATCCCTTTGATTCCAGAATTAT
GTTATCTGCAGGACATGATGGCAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTATTTTAATATGATTGAAGGACA
AGGACATGGAGCTGTGTTTGACTGTAAGTTTTCACAGGATGGACAGCATTTTGCCTGTACAGATTCTCATGGGCACCTTCTGATATTTGG
TTTTGGATGCAGCAAACCATATGAAAAGATTCCTGATCAGATGTTCTTCCATACTGACTATCGACCACTTATTAGAGATTCTAATAATTA
TGTCTTAGATGAGCAAACTCAGCAGGCTCCTCATCTTATGCCTCCACCATTCTTGGTAGATGTAGATGGAAATCCTCATCCAACCAAGTA
TCAGAGATTAGTACCAGGCCGAGAAAATTCTGCAGATGAACATTTGATTCCACAGCTGGGCTATGTGGCAACAAGTGATGGAGAGGTGAT
TGAACAAATTATAAGCCTGCAAACCAATGATAATGATGAACGCAGCCCAGAATCGAGTATTCTTGATGGAATGATAAGACAGTTGCAGCA
GCAGCAAGATCAGAGAATGGGAGCAGATCAGGATACTATTCCAAGAGGACTTTCAAATGGTGAAGAAACACCCCGGAGAGGTTTTAGAAG
GCTGAGCTTAGACATTCAGTCCCCTCCAAATATTGGTCTGCGTCGTAGTGGACAAGTTGAAGGTGTTCGTCAGATGCATCAAAACGCTCC
ACGCAGTCAGATTGCTACAGAACGTGACCTGCAGGCTTGGAAACGAAGAGTGGTTGTACCAGAGGTACCACTAGGCATATTTAGGAAGCT
GGAAGACTTCCGATTAGAGAAAGGTGAAGAGGAAAGAAATCTTTATATAATAGGAAGAAAAAGAAAGACTCTTCAGCTCTCACATAAGGA
CTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGGGCAACCATGAGTTGTATATGCGCCGCAGGAA
GCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAGCGGCAACAGCTGGAAACAGA
GAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTGCGGCTGCAGGACTATGAGGA
GAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGGAAGCGGGCACAGGAGGAGGC
CGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGATCAGATAAAGAGCCAGGAGCA
GCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAAGAGTGGCA
GCACAGGGCCAAAGAAGCCCAGGATGACCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGATGACAGCACCCCCGCCCCCACCACCCCC
CGTGTACGAGCCGGTGAGCTACCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTACAGCGCGGAGCTGTCTAGTGA
GGGCATCCGGGATGACCGCAATGAGGAGAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGGCAGCTGCTGACGCTGAGCAG
CGAGCTGTCCCAGGCCCGAGATGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGGCAAGGCCGGGACAAGTACAA
GACGCTGCGGCAGATCCGGCAGGGCAACACCAAGCAGCGCATCGACGAGTTCGAGGCCCTGTAACAGCCAGGCCAGGACCAAGGGCAGAG
GGGTGCTCATAGCGGGCGCTGCCAGCCCCGCCACGCTTGTGTCTTTAGTGCTCCAAGTCTAGGAACTCCCTCAGATCCCAGTTCCTTTAG
AAAGCAGTTACCCAACAGAAACATTCTGGGCTGGGAACCAGGGAGGCGCCCTGGTTTGTTTTCCCCAGTTGTAATAGTGCCAAGCAGGCC
TGATTCTCGCGATTATTCTCGAATCACCTCCTGTGTTGTGCTGGGAGCAGGACTGATTGAATTACGGAAAATGCCTGTAAAGTCTGAGTA
AGAAACTTCATGCTGGCCTGTGTGATACAAGAGTCAGCATCATTAAAGGAAACGTGGCAGGACTTCCATCTGTGCCATACTTGTTCTGTA
TTCGAAATGAGCTCAAATTGATTTTTTAATTTCTATGAAGGATCCATCTTTGTATATTTACATGCTTAGAGGGGTGAAAATTATTTTGGA
AATTGAGTCTGAAGCACTCTCGCACACACAGTGATTCCCTCCTCCCGTCACTCCACGCAGCTGGCAGAGAGCACAGTGATCACCAGCGTG
AGTGGTGGAGGAGGACACTTGGATTTTTTTTTTTGTTTTTTTTTTTTTTGCTTAACAGTTTTAGAATACATTGTACTTATACACCTTATT
AATGATCAGCTATATACTATTTATATACAAGTGATAATACAGATTTGTAACATTAGTTTTAAAAAGGGAAAGTTTTGTTCTGTATATTTT
GTTACCTTTTACAGAATAAAAGAATTACATATGAAAAACCCTCTAAACCATGGCACTTGATGTGATGTGGCAGGAGGGCAGTGGTGGAGC
TGGACCTGCCTGCTGCAGTCACGTGTAAACAGGATTATTATTAGTGTTTTATGCATGTAATGGACTATGCACACTTTTAATTTTGTCAGA
TTCACACATGCCACTATGAGCTTTCAGACTCCAGCTGTGAAGAGACTCTGTTTGCTTGTGTTTGTTTGTTTGCAGTCTCTCTCTGCCATG
GCCTTGGCAGGCTGCTGGAAGGCAGCTTGTGGAGGCCGTTGGTTCCGCCCACTCATTCCTTCTCGTGCACTGCTTTCTCCTTCACAGCTA

>10344_10344_4_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000342449_EZR_chr6_159192439_ENST00000337147_length(amino acids)=1104AA_BP=783
MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLD
KEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR
RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHT
GSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK
IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVL
KVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHL
LIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKYQRLVPGRENSADEHLIPQLGYVATSD
GEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMH
QNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQLSHKDFVFYAPRLRINKRILQLCMGNHELYM
RRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRA
QEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPP
PPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGR

--------------------------------------------------------------
>10344_10344_5_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000342449_EZR_chr6_159192439_ENST00000367075_length(transcript)=4560nt_BP=2428nt
CGCCAGCCCGGTCAGGCCTCGGCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCGCGCCCGGCCATGGCGGAGCC
GTCGTCCGCCCGACGCCCGGTGCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCGGCGGGCCCGTGTCGGAGAGC
GGCCCAGGTGCTGGTGCAGGAGCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAACGAGCACAACAGGAGCTACGA
GGAGTTGGTCTTGTCCAATAAGCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCTATGTTGGATAAAGAAATTCC
ACCCAGTATTTCAAGAGTCACTTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGACTGCAGGCACACAGTTTGGAA
GGGCTCTGCCTTTGCTGCTCTTCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCAAATCTTGTGGAGATACATCG
AGGAAAACAACTCACAGGGTGTTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAAATGCACAGAAGGATTCTCGG
ACATCTATCTGCTGTTTACTGTGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGACTGTTTGGTAAAGATTTGGTC
AACACATAATGGCCGCTTGTTATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAACTATGAGAATACAATGATTGC
TGCGGGGAGCTGTGATAAAATTATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAAGGACACACAGGATCAATTAC
ATCTTTACAGTTTAGCCCGATGGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACAGTTTGCTTTTGGCAATGGGA
TTTAGAATCCTTAAAATTTAGCCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATGCTTTGTTCTTCTTTTAGTGT
TGGTGGTATGTTTTTAGCCACAGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCACCCGAAAAAATCGCAGAACT
TGAAAGCCACACTGATAAAGTAGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGCAGAGATGGAACAGCACGGAT
TTGGAGATTTGAGCAGTTAGAATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTATCTTCCGAAGAGGAAAGGTT
TATGAAACCTAAAGTAACAATGATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGATCATGTCCTCAAAGTGTGGAA
TTCTTACACTGGACAACTGCTTCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACATCCCTTTGATTCCAGAATTAT
GTTATCTGCAGGACATGATGGCAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTATTTTAATATGATTGAAGGACA
AGGACATGGAGCTGTGTTTGACTGTAAGTTTTCACAGGATGGACAGCATTTTGCCTGTACAGATTCTCATGGGCACCTTCTGATATTTGG
TTTTGGATGCAGCAAACCATATGAAAAGATTCCTGATCAGATGTTCTTCCATACTGACTATCGACCACTTATTAGAGATTCTAATAATTA
TGTCTTAGATGAGCAAACTCAGCAGGCTCCTCATCTTATGCCTCCACCATTCTTGGTAGATGTAGATGGAAATCCTCATCCAACCAAGTA
TCAGAGATTAGTACCAGGCCGAGAAAATTCTGCAGATGAACATTTGATTCCACAGCTGGGCTATGTGGCAACAAGTGATGGAGAGGTGAT
TGAACAAATTATAAGCCTGCAAACCAATGATAATGATGAACGCAGCCCAGAATCGAGTATTCTTGATGGAATGATAAGACAGTTGCAGCA
GCAGCAAGATCAGAGAATGGGAGCAGATCAGGATACTATTCCAAGAGGACTTTCAAATGGTGAAGAAACACCCCGGAGAGGTTTTAGAAG
GCTGAGCTTAGACATTCAGTCCCCTCCAAATATTGGTCTGCGTCGTAGTGGACAAGTTGAAGGTGTTCGTCAGATGCATCAAAACGCTCC
ACGCAGTCAGATTGCTACAGAACGTGACCTGCAGGCTTGGAAACGAAGAGTGGTTGTACCAGAGGTACCACTAGGCATATTTAGGAAGCT
GGAAGACTTCCGATTAGAGAAAGGTGAAGAGGAAAGAAATCTTTATATAATAGGAAGAAAAAGAAAGACTCTTCAGCTCTCACATAAGGA
CTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGGGCAACCATGAGTTGTATATGCGCCGCAGGAA
GCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAGCGGCAACAGCTGGAAACAGA
GAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTGCGGCTGCAGGACTATGAGGA
GAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGGAAGCGGGCACAGGAGGAGGC
CGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGATCAGATAAAGAGCCAGGAGCA
GCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAAGAGTGGCA
GCACAGGGCCAAAGAAGCCCAGGATGACCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGATGACAGCACCCCCGCCCCCACCACCCCC
CGTGTACGAGCCGGTGAGCTACCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTACAGCGCGGAGCTGTCTAGTGA
GGGCATCCGGGATGACCGCAATGAGGAGAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGGCAGCTGCTGACGCTGAGCAG
CGAGCTGTCCCAGGCCCGAGATGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGGCAAGGCCGGGACAAGTACAA
GACGCTGCGGCAGATCCGGCAGGGCAACACCAAGCAGCGCATCGACGAGTTCGAGGCCCTGTAACAGCCAGGCCAGGACCAAGGGCAGAG
GGGTGCTCATAGCGGGCGCTGCCAGCCCCGCCACGCTTGTGTCTTTAGTGCTCCAAGTCTAGGAACTCCCTCAGATCCCAGTTCCTTTAG
AAAGCAGTTACCCAACAGAAACATTCTGGGCTGGGAACCAGGGAGGCGCCCTGGTTTGTTTTCCCCAGTTGTAATAGTGCCAAGCAGGCC
TGATTCTCGCGATTATTCTCGAATCACCTCCTGTGTTGTGCTGGGAGCAGGACTGATTGAATTACGGAAAATGCCTGTAAAGTCTGAGTA
AGAAACTTCATGCTGGCCTGTGTGATACAAGAGTCAGCATCATTAAAGGAAACGTGGCAGGACTTCCATCTGTGCCATACTTGTTCTGTA
TTCGAAATGAGCTCAAATTGATTTTTTAATTTCTATGAAGGATCCATCTTTGTATATTTACATGCTTAGAGGGGTGAAAATTATTTTGGA
AATTGAGTCTGAAGCACTCTCGCACACACAGTGATTCCCTCCTCCCGTCACTCCACGCAGCTGGCAGAGAGCACAGTGATCACCAGCGTG
AGTGGTGGAGGAGGACACTTGGATTTTTTTTTTTGTTTTTTTTTTTTTTGCTTAACAGTTTTAGAATACATTGTACTTATACACCTTATT
AATGATCAGCTATATACTATTTATATACAAGTGATAATACAGATTTGTAACATTAGTTTTAAAAAGGGAAAGTTTTGTTCTGTATATTTT
GTTACCTTTTACAGAATAAAAGAATTACATATGAAAAACCCTCTAAACCATGGCACTTGATGTGATGTGGCAGGAGGGCAGTGGTGGAGC
TGGACCTGCCTGCTGCAGTCACGTGTAAACAGGATTATTATTAGTGTTTTATGCATGTAATGGACTATGCACACTTTTAATTTTGTCAGA
TTCACACATGCCACTATGAGCTTTCAGACTCCAGCTGTGAAGAGACTCTGTTTGCTTGTGTTTGTTTGTTTGCAGTCTCTCTCTGCCATG
GCCTTGGCAGGCTGCTGGAAGGCAGCTTGTGGAGGCCGTTGGTTCCGCCCACTCATTCCTTCTCGTGCACTGCTTTCTCCTTCACAGCTA

>10344_10344_5_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000342449_EZR_chr6_159192439_ENST00000367075_length(amino acids)=1104AA_BP=783
MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLD
KEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR
RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHT
GSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK
IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVL
KVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHL
LIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKYQRLVPGRENSADEHLIPQLGYVATSD
GEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMH
QNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQLSHKDFVFYAPRLRINKRILQLCMGNHELYM
RRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRA
QEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPP
PPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGR

--------------------------------------------------------------
>10344_10344_6_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000342449_EZR_chr6_159192439_ENST00000392177_length(transcript)=3412nt_BP=2428nt
CGCCAGCCCGGTCAGGCCTCGGCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCGCGCCCGGCCATGGCGGAGCC
GTCGTCCGCCCGACGCCCGGTGCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCGGCGGGCCCGTGTCGGAGAGC
GGCCCAGGTGCTGGTGCAGGAGCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAACGAGCACAACAGGAGCTACGA
GGAGTTGGTCTTGTCCAATAAGCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCTATGTTGGATAAAGAAATTCC
ACCCAGTATTTCAAGAGTCACTTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGACTGCAGGCACACAGTTTGGAA
GGGCTCTGCCTTTGCTGCTCTTCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCAAATCTTGTGGAGATACATCG
AGGAAAACAACTCACAGGGTGTTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAAATGCACAGAAGGATTCTCGG
ACATCTATCTGCTGTTTACTGTGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGACTGTTTGGTAAAGATTTGGTC
AACACATAATGGCCGCTTGTTATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAACTATGAGAATACAATGATTGC
TGCGGGGAGCTGTGATAAAATTATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAAGGACACACAGGATCAATTAC
ATCTTTACAGTTTAGCCCGATGGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACAGTTTGCTTTTGGCAATGGGA
TTTAGAATCCTTAAAATTTAGCCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATGCTTTGTTCTTCTTTTAGTGT
TGGTGGTATGTTTTTAGCCACAGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCACCCGAAAAAATCGCAGAACT
TGAAAGCCACACTGATAAAGTAGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGCAGAGATGGAACAGCACGGAT
TTGGAGATTTGAGCAGTTAGAATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTATCTTCCGAAGAGGAAAGGTT
TATGAAACCTAAAGTAACAATGATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGATCATGTCCTCAAAGTGTGGAA
TTCTTACACTGGACAACTGCTTCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACATCCCTTTGATTCCAGAATTAT
GTTATCTGCAGGACATGATGGCAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTATTTTAATATGATTGAAGGACA
AGGACATGGAGCTGTGTTTGACTGTAAGTTTTCACAGGATGGACAGCATTTTGCCTGTACAGATTCTCATGGGCACCTTCTGATATTTGG
TTTTGGATGCAGCAAACCATATGAAAAGATTCCTGATCAGATGTTCTTCCATACTGACTATCGACCACTTATTAGAGATTCTAATAATTA
TGTCTTAGATGAGCAAACTCAGCAGGCTCCTCATCTTATGCCTCCACCATTCTTGGTAGATGTAGATGGAAATCCTCATCCAACCAAGTA
TCAGAGATTAGTACCAGGCCGAGAAAATTCTGCAGATGAACATTTGATTCCACAGCTGGGCTATGTGGCAACAAGTGATGGAGAGGTGAT
TGAACAAATTATAAGCCTGCAAACCAATGATAATGATGAACGCAGCCCAGAATCGAGTATTCTTGATGGAATGATAAGACAGTTGCAGCA
GCAGCAAGATCAGAGAATGGGAGCAGATCAGGATACTATTCCAAGAGGACTTTCAAATGGTGAAGAAACACCCCGGAGAGGTTTTAGAAG
GCTGAGCTTAGACATTCAGTCCCCTCCAAATATTGGTCTGCGTCGTAGTGGACAAGTTGAAGGTGTTCGTCAGATGCATCAAAACGCTCC
ACGCAGTCAGATTGCTACAGAACGTGACCTGCAGGCTTGGAAACGAAGAGTGGTTGTACCAGAGGTACCACTAGGCATATTTAGGAAGCT
GGAAGACTTCCGATTAGAGAAAGGTGAAGAGGAAAGAAATCTTTATATAATAGGAAGAAAAAGAAAGACTCTTCAGCTCTCACATAAGGA
CTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGGGCAACCATGAGTTGTATATGCGCCGCAGGAA
GCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAGCGGCAACAGCTGGAAACAGA
GAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTGCGGCTGCAGGACTATGAGGA
GAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGGAAGCGGGCACAGGAGGAGGC
CGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGATCAGATAAAGAGCCAGGAGCA
GCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAAGAGTGGCA
GCACAGGGCCAAAGAAGCCCAGGATGACCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGATGACAGCACCCCCGCCCCCACCACCCCC
CGTGTACGAGCCGGTGAGCTACCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTACAGCGCGGAGCTGTCTAGTGA
GGGCATCCGGGATGACCGCAATGAGGAGAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGGCAGCTGCTGACGCTGAGCAG
CGAGCTGTCCCAGGCCCGAGATGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGGCAAGGCCGGGACAAGTACAA

>10344_10344_6_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000342449_EZR_chr6_159192439_ENST00000392177_length(amino acids)=1104AA_BP=783
MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLD
KEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR
RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHT
GSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK
IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVL
KVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHL
LIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKYQRLVPGRENSADEHLIPQLGYVATSD
GEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMH
QNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQLSHKDFVFYAPRLRINKRILQLCMGNHELYM
RRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRA
QEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPP
PPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGR

--------------------------------------------------------------
>10344_10344_7_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000380800_EZR_chr6_159192439_ENST00000337147_length(transcript)=4587nt_BP=2448nt
GCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCGGCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCG
CGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGTGCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCG
GCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGAGCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAAC
GAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAAGCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCT
ATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCACTTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGAC
TGCAGGCACACAGTTTGGAAGGGCTCTGCCTTTGCTGCTCTTCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCA
AATCTTGTGGAGATACATCGAGGAAAACAACTCACAGGGTGTTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAA
ATGCACAGAAGGATTCTCGGACATCTATCTGCTGTTTACTGTGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGAC
TGTTTGGTAAAGATTTGGTCAACACATAATGGCCGCTTGTTATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAAC
TATGAGAATACAATGATTGCTGCGGGGAGCTGTGATAAAATTATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAA
GGACACACAGGATCAATTACATCTTTACAGTTTAGCCCGATGGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACA
GTTTGCTTTTGGCAATGGGATTTAGAATCCTTAAAATTTAGCCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATG
CTTTGTTCTTCTTTTAGTGTTGGTGGTATGTTTTTAGCCACAGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCA
CCCGAAAAAATCGCAGAACTTGAAAGCCACACTGATAAAGTAGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGC
AGAGATGGAACAGCACGGATTTGGAGATTTGAGCAGTTAGAATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTA
TCTTCCGAAGAGGAAAGGTTTATGAAACCTAAAGTAACAATGATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGAT
CATGTCCTCAAAGTGTGGAATTCTTACACTGGACAACTGCTTCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACAT
CCCTTTGATTCCAGAATTATGTTATCTGCAGGACATGATGGCAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTAT
TTTAATATGATTGAAGGACAAGGACATGGAGCTGTGTTTGACTGTAAGTTTTCACAGGATGGACAGCATTTTGCCTGTACAGATTCTCAT
GGGCACCTTCTGATATTTGGTTTTGGATGCAGCAAACCATATGAAAAGATTCCTGATCAGATGTTCTTCCATACTGACTATCGACCACTT
ATTAGAGATTCTAATAATTATGTCTTAGATGAGCAAACTCAGCAGGCTCCTCATCTTATGCCTCCACCATTCTTGGTAGATGTAGATGGA
AATCCTCATCCAACCAAGTATCAGAGATTAGTACCAGGCCGAGAAAATTCTGCAGATGAACATTTGATTCCACAGCTGGGCTATGTGGCA
ACAAGTGATGGAGAGGTGATTGAACAAATTATAAGCCTGCAAACCAATGATAATGATGAACGCAGCCCAGAATCGAGTATTCTTGATGGA
ATGATAAGACAGTTGCAGCAGCAGCAAGATCAGAGAATGGGAGCAGATCAGGATACTATTCCAAGAGGACTTTCAAATGGTGAAGAAACA
CCCCGGAGAGGTTTTAGAAGGCTGAGCTTAGACATTCAGTCCCCTCCAAATATTGGTCTGCGTCGTAGTGGACAAGTTGAAGGTGTTCGT
CAGATGCATCAAAACGCTCCACGCAGTCAGATTGCTACAGAACGTGACCTGCAGGCTTGGAAACGAAGAGTGGTTGTACCAGAGGTACCA
CTAGGCATATTTAGGAAGCTGGAAGACTTCCGATTAGAGAAAGGTGAAGAGGAAAGAAATCTTTATATAATAGGAAGAAAAAGAAAGACT
CTTCAGCTCTCACATAAGGACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGGGCAACCATGAG
TTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAG
CGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTG
CGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGG
AAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGAT
CAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAG
GATGAAGTTGAAGAGTGGCAGCACAGGGCCAAAGAAGCCCAGGATGACCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGATGACAGCA
CCCCCGCCCCCACCACCCCCCGTGTACGAGCCGGTGAGCTACCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTAC
AGCGCGGAGCTGTCTAGTGAGGGCATCCGGGATGACCGCAATGAGGAGAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGG
CAGCTGCTGACGCTGAGCAGCGAGCTGTCCCAGGCCCGAGATGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGG
CAAGGCCGGGACAAGTACAAGACGCTGCGGCAGATCCGGCAGGGCAACACCAAGCAGCGCATCGACGAGTTCGAGGCCCTGTAACAGCCA
GGCCAGGACCAAGGGCAGAGGGGTGCTCATAGCGGGCGCTGCCAGCCCCGCCACGCTTGTGTCTTTAGTGCTCCAAGTCTAGGAACTCCC
TCAGATCCCAGTTCCTTTAGAAAGCAGTTACCCAACAGAAACATTCTGGGCTGGGAACCAGGGAGGCGCCCTGGTTTGTTTTCCCCAGTT
GTAATAGTGCCAAGCAGGCCTGATTCTCGCGATTATTCTCGAATCACCTCCTGTGTTGTGCTGGGAGCAGGACTGATTGAATTACGGAAA
ATGCCTGTAAAGTCTGAGTAAGAAACTTCATGCTGGCCTGTGTGATACAAGAGTCAGCATCATTAAAGGAAACGTGGCAGGACTTCCATC
TGTGCCATACTTGTTCTGTATTCGAAATGAGCTCAAATTGATTTTTTAATTTCTATGAAGGATCCATCTTTGTATATTTACATGCTTAGA
GGGGTGAAAATTATTTTGGAAATTGAGTCTGAAGCACTCTCGCACACACAGTGATTCCCTCCTCCCGTCACTCCACGCAGCTGGCAGAGA
GCACAGTGATCACCAGCGTGAGTGGTGGAGGAGGACACTTGGATTTTTTTTTTTGTTTTTTTTTTTTTTGCTTAACAGTTTTAGAATACA
TTGTACTTATACACCTTATTAATGATCAGCTATATACTATTTATATACAAGTGATAATACAGATTTGTAACATTAGTTTTAAAAAGGGAA
AGTTTTGTTCTGTATATTTTGTTACCTTTTACAGAATAAAAGAATTACATATGAAAAACCCTCTAAACCATGGCACTTGATGTGATGTGG
CAGGAGGGCAGTGGTGGAGCTGGACCTGCCTGCTGCAGTCACGTGTAAACAGGATTATTATTAGTGTTTTATGCATGTAATGGACTATGC
ACACTTTTAATTTTGTCAGATTCACACATGCCACTATGAGCTTTCAGACTCCAGCTGTGAAGAGACTCTGTTTGCTTGTGTTTGTTTGTT
TGCAGTCTCTCTCTGCCATGGCCTTGGCAGGCTGCTGGAAGGCAGCTTGTGGAGGCCGTTGGTTCCGCCCACTCATTCCTTCTCGTGCAC

>10344_10344_7_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000380800_EZR_chr6_159192439_ENST00000337147_length(amino acids)=1135AA_BP=814
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN
MIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNP
HPTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRMGADQDTIPRGLSNGEETPR
RGFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQ
LSHKDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRL
QDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDE
VEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQL

--------------------------------------------------------------
>10344_10344_8_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000380800_EZR_chr6_159192439_ENST00000367075_length(transcript)=4580nt_BP=2448nt
GCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCGGCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCG
CGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGTGCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCG
GCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGAGCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAAC
GAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAAGCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCT
ATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCACTTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGAC
TGCAGGCACACAGTTTGGAAGGGCTCTGCCTTTGCTGCTCTTCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCA
AATCTTGTGGAGATACATCGAGGAAAACAACTCACAGGGTGTTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAA
ATGCACAGAAGGATTCTCGGACATCTATCTGCTGTTTACTGTGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGAC
TGTTTGGTAAAGATTTGGTCAACACATAATGGCCGCTTGTTATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAAC
TATGAGAATACAATGATTGCTGCGGGGAGCTGTGATAAAATTATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAA
GGACACACAGGATCAATTACATCTTTACAGTTTAGCCCGATGGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACA
GTTTGCTTTTGGCAATGGGATTTAGAATCCTTAAAATTTAGCCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATG
CTTTGTTCTTCTTTTAGTGTTGGTGGTATGTTTTTAGCCACAGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCA
CCCGAAAAAATCGCAGAACTTGAAAGCCACACTGATAAAGTAGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGC
AGAGATGGAACAGCACGGATTTGGAGATTTGAGCAGTTAGAATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTA
TCTTCCGAAGAGGAAAGGTTTATGAAACCTAAAGTAACAATGATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGAT
CATGTCCTCAAAGTGTGGAATTCTTACACTGGACAACTGCTTCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACAT
CCCTTTGATTCCAGAATTATGTTATCTGCAGGACATGATGGCAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTAT
TTTAATATGATTGAAGGACAAGGACATGGAGCTGTGTTTGACTGTAAGTTTTCACAGGATGGACAGCATTTTGCCTGTACAGATTCTCAT
GGGCACCTTCTGATATTTGGTTTTGGATGCAGCAAACCATATGAAAAGATTCCTGATCAGATGTTCTTCCATACTGACTATCGACCACTT
ATTAGAGATTCTAATAATTATGTCTTAGATGAGCAAACTCAGCAGGCTCCTCATCTTATGCCTCCACCATTCTTGGTAGATGTAGATGGA
AATCCTCATCCAACCAAGTATCAGAGATTAGTACCAGGCCGAGAAAATTCTGCAGATGAACATTTGATTCCACAGCTGGGCTATGTGGCA
ACAAGTGATGGAGAGGTGATTGAACAAATTATAAGCCTGCAAACCAATGATAATGATGAACGCAGCCCAGAATCGAGTATTCTTGATGGA
ATGATAAGACAGTTGCAGCAGCAGCAAGATCAGAGAATGGGAGCAGATCAGGATACTATTCCAAGAGGACTTTCAAATGGTGAAGAAACA
CCCCGGAGAGGTTTTAGAAGGCTGAGCTTAGACATTCAGTCCCCTCCAAATATTGGTCTGCGTCGTAGTGGACAAGTTGAAGGTGTTCGT
CAGATGCATCAAAACGCTCCACGCAGTCAGATTGCTACAGAACGTGACCTGCAGGCTTGGAAACGAAGAGTGGTTGTACCAGAGGTACCA
CTAGGCATATTTAGGAAGCTGGAAGACTTCCGATTAGAGAAAGGTGAAGAGGAAAGAAATCTTTATATAATAGGAAGAAAAAGAAAGACT
CTTCAGCTCTCACATAAGGACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGGGCAACCATGAG
TTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAG
CGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTG
CGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGG
AAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGAT
CAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAG
GATGAAGTTGAAGAGTGGCAGCACAGGGCCAAAGAAGCCCAGGATGACCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGATGACAGCA
CCCCCGCCCCCACCACCCCCCGTGTACGAGCCGGTGAGCTACCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTAC
AGCGCGGAGCTGTCTAGTGAGGGCATCCGGGATGACCGCAATGAGGAGAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGG
CAGCTGCTGACGCTGAGCAGCGAGCTGTCCCAGGCCCGAGATGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGG
CAAGGCCGGGACAAGTACAAGACGCTGCGGCAGATCCGGCAGGGCAACACCAAGCAGCGCATCGACGAGTTCGAGGCCCTGTAACAGCCA
GGCCAGGACCAAGGGCAGAGGGGTGCTCATAGCGGGCGCTGCCAGCCCCGCCACGCTTGTGTCTTTAGTGCTCCAAGTCTAGGAACTCCC
TCAGATCCCAGTTCCTTTAGAAAGCAGTTACCCAACAGAAACATTCTGGGCTGGGAACCAGGGAGGCGCCCTGGTTTGTTTTCCCCAGTT
GTAATAGTGCCAAGCAGGCCTGATTCTCGCGATTATTCTCGAATCACCTCCTGTGTTGTGCTGGGAGCAGGACTGATTGAATTACGGAAA
ATGCCTGTAAAGTCTGAGTAAGAAACTTCATGCTGGCCTGTGTGATACAAGAGTCAGCATCATTAAAGGAAACGTGGCAGGACTTCCATC
TGTGCCATACTTGTTCTGTATTCGAAATGAGCTCAAATTGATTTTTTAATTTCTATGAAGGATCCATCTTTGTATATTTACATGCTTAGA
GGGGTGAAAATTATTTTGGAAATTGAGTCTGAAGCACTCTCGCACACACAGTGATTCCCTCCTCCCGTCACTCCACGCAGCTGGCAGAGA
GCACAGTGATCACCAGCGTGAGTGGTGGAGGAGGACACTTGGATTTTTTTTTTTGTTTTTTTTTTTTTTGCTTAACAGTTTTAGAATACA
TTGTACTTATACACCTTATTAATGATCAGCTATATACTATTTATATACAAGTGATAATACAGATTTGTAACATTAGTTTTAAAAAGGGAA
AGTTTTGTTCTGTATATTTTGTTACCTTTTACAGAATAAAAGAATTACATATGAAAAACCCTCTAAACCATGGCACTTGATGTGATGTGG
CAGGAGGGCAGTGGTGGAGCTGGACCTGCCTGCTGCAGTCACGTGTAAACAGGATTATTATTAGTGTTTTATGCATGTAATGGACTATGC
ACACTTTTAATTTTGTCAGATTCACACATGCCACTATGAGCTTTCAGACTCCAGCTGTGAAGAGACTCTGTTTGCTTGTGTTTGTTTGTT
TGCAGTCTCTCTCTGCCATGGCCTTGGCAGGCTGCTGGAAGGCAGCTTGTGGAGGCCGTTGGTTCCGCCCACTCATTCCTTCTCGTGCAC

>10344_10344_8_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000380800_EZR_chr6_159192439_ENST00000367075_length(amino acids)=1135AA_BP=814
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN
MIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNP
HPTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRMGADQDTIPRGLSNGEETPR
RGFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQ
LSHKDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRL
QDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDE
VEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQL

--------------------------------------------------------------
>10344_10344_9_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000380800_EZR_chr6_159192439_ENST00000392177_length(transcript)=3432nt_BP=2448nt
GCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCGGCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCG
CGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGTGCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCG
GCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGAGCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAAC
GAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAAGCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCT
ATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCACTTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGAC
TGCAGGCACACAGTTTGGAAGGGCTCTGCCTTTGCTGCTCTTCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCA
AATCTTGTGGAGATACATCGAGGAAAACAACTCACAGGGTGTTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAA
ATGCACAGAAGGATTCTCGGACATCTATCTGCTGTTTACTGTGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGAC
TGTTTGGTAAAGATTTGGTCAACACATAATGGCCGCTTGTTATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAAC
TATGAGAATACAATGATTGCTGCGGGGAGCTGTGATAAAATTATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAA
GGACACACAGGATCAATTACATCTTTACAGTTTAGCCCGATGGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACA
GTTTGCTTTTGGCAATGGGATTTAGAATCCTTAAAATTTAGCCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATG
CTTTGTTCTTCTTTTAGTGTTGGTGGTATGTTTTTAGCCACAGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCA
CCCGAAAAAATCGCAGAACTTGAAAGCCACACTGATAAAGTAGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGC
AGAGATGGAACAGCACGGATTTGGAGATTTGAGCAGTTAGAATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTA
TCTTCCGAAGAGGAAAGGTTTATGAAACCTAAAGTAACAATGATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGAT
CATGTCCTCAAAGTGTGGAATTCTTACACTGGACAACTGCTTCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACAT
CCCTTTGATTCCAGAATTATGTTATCTGCAGGACATGATGGCAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTAT
TTTAATATGATTGAAGGACAAGGACATGGAGCTGTGTTTGACTGTAAGTTTTCACAGGATGGACAGCATTTTGCCTGTACAGATTCTCAT
GGGCACCTTCTGATATTTGGTTTTGGATGCAGCAAACCATATGAAAAGATTCCTGATCAGATGTTCTTCCATACTGACTATCGACCACTT
ATTAGAGATTCTAATAATTATGTCTTAGATGAGCAAACTCAGCAGGCTCCTCATCTTATGCCTCCACCATTCTTGGTAGATGTAGATGGA
AATCCTCATCCAACCAAGTATCAGAGATTAGTACCAGGCCGAGAAAATTCTGCAGATGAACATTTGATTCCACAGCTGGGCTATGTGGCA
ACAAGTGATGGAGAGGTGATTGAACAAATTATAAGCCTGCAAACCAATGATAATGATGAACGCAGCCCAGAATCGAGTATTCTTGATGGA
ATGATAAGACAGTTGCAGCAGCAGCAAGATCAGAGAATGGGAGCAGATCAGGATACTATTCCAAGAGGACTTTCAAATGGTGAAGAAACA
CCCCGGAGAGGTTTTAGAAGGCTGAGCTTAGACATTCAGTCCCCTCCAAATATTGGTCTGCGTCGTAGTGGACAAGTTGAAGGTGTTCGT
CAGATGCATCAAAACGCTCCACGCAGTCAGATTGCTACAGAACGTGACCTGCAGGCTTGGAAACGAAGAGTGGTTGTACCAGAGGTACCA
CTAGGCATATTTAGGAAGCTGGAAGACTTCCGATTAGAGAAAGGTGAAGAGGAAAGAAATCTTTATATAATAGGAAGAAAAAGAAAGACT
CTTCAGCTCTCACATAAGGACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGGGCAACCATGAG
TTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAG
CGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTG
CGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGG
AAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGAT
CAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAG
GATGAAGTTGAAGAGTGGCAGCACAGGGCCAAAGAAGCCCAGGATGACCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGATGACAGCA
CCCCCGCCCCCACCACCCCCCGTGTACGAGCCGGTGAGCTACCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTAC
AGCGCGGAGCTGTCTAGTGAGGGCATCCGGGATGACCGCAATGAGGAGAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGG
CAGCTGCTGACGCTGAGCAGCGAGCTGTCCCAGGCCCGAGATGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGG
CAAGGCCGGGACAAGTACAAGACGCTGCGGCAGATCCGGCAGGGCAACACCAAGCAGCGCATCGACGAGTTCGAGGCCCTGTAACAGCCA

>10344_10344_9_BRWD1-EZR_BRWD1_chr21_40622722_ENST00000380800_EZR_chr6_159192439_ENST00000392177_length(amino acids)=1135AA_BP=814
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN
MIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNP
HPTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRMGADQDTIPRGLSNGEETPR
RGFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQ
LSHKDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRL
QDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDE
VEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for BRWD1-EZR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneEZRchr21:40622722chr6:159192439ENST00000337147613244_586265.0587.0SCYL3
TgeneEZRchr21:40622722chr6:159192439ENST00000367075714244_586265.0587.0SCYL3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRWD1-EZR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRWD1-EZR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRWD1C0028960Oligospermia1CTD_human
TgeneC0033578Prostatic Neoplasms3CTD_human
TgeneC0376358Malignant neoplasm of prostate3CTD_human
TgeneC0007097Carcinoma1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0024667Animal Mammary Neoplasms1CTD_human
TgeneC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneC0027627Neoplasm Metastasis1CTD_human
TgeneC0029408Degenerative polyarthritis1CTD_human
TgeneC0086743Osteoarthrosis Deformans1CTD_human
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC1257925Mammary Carcinoma, Animal1CTD_human