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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATAD2B-MMP15 (FusionGDB2 ID:HG54454TG4324)

Fusion Gene Summary for ATAD2B-MMP15

check button Fusion gene summary
Fusion gene informationFusion gene name: ATAD2B-MMP15
Fusion gene ID: hg54454tg4324
HgeneTgene
Gene symbol

ATAD2B

MMP15

Gene ID

54454

4324

Gene nameATPase family AAA domain containing 2Bmatrix metallopeptidase 15
Synonyms-MMP-15|MT2-MMP|MT2MMP|MTMMP2|SMCP-2
Cytomap('ATAD2B')('MMP15')

2p24.1-p23.3

16q21

Type of geneprotein-codingprotein-coding
DescriptionATPase family AAA domain-containing protein 2Bmatrix metalloproteinase-15MT-MMP 2matrix metallopeptidase 15 (membrane-inserted)matrix metalloproteinase 15 (membrane-inserted)membrane-type matrix metalloproteinase 2membrane-type-2 matrix metalloproteinase
Modification date2020031320200313
UniProtAcc.

P51511

Ensembl transtripts involved in fusion geneENST00000238789, ENST00000474583, 
Fusion gene scores* DoF score7 X 7 X 4=1961 X 1 X 1=1
# samples 71
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ATAD2B [Title/Abstract] AND MMP15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATAD2B(24056788)-MMP15(58071375), # samples:1
Anticipated loss of major functional domain due to fusion event.ATAD2B-MMP15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATAD2B-MMP15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATAD2B-MMP15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATAD2B-MMP15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATAD2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MMP15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer219NATAD2Bchr2

24056788

-MMP15chr16

58071375

+


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Fusion Gene ORF analysis for ATAD2B-MMP15

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000238789ENST00000219271ATAD2Bchr2

24056788

-MMP15chr16

58071375

+
intron-3CDSENST00000474583ENST00000219271ATAD2Bchr2

24056788

-MMP15chr16

58071375

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000238789ATAD2Bchr224056788-ENST00000219271MMP15chr1658071375+5375207227239191215

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000238789ENST00000219271ATAD2Bchr224056788-MMP15chr1658071375+0.0015320720.99846786

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Fusion Genomic Features for ATAD2B-MMP15


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATAD2Bchr224056788-MMP15chr1658071375+6.12E-050.99993885
ATAD2Bchr224056788-MMP15chr1658071375+6.12E-050.99993885

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATAD2B-MMP15


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:24056788/chr16:58071375)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MMP15

P51511

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. {ECO:0000269|PubMed:9461298}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATAD2Bchr2:24056788chr16:58071375ENST00000238789-1428257_2625761459.0Compositional biasNote=Poly-Glu
HgeneATAD2Bchr2:24056788chr16:58071375ENST00000238789-1428441_4485761459.0Nucleotide bindingATP
TgeneMMP15chr2:24056788chr16:58071375ENST00000219271010331_34054670.0Compositional biasNote=Poly-Pro
TgeneMMP15chr2:24056788chr16:58071375ENST00000219271010109_11654670.0MotifCysteine switch
TgeneMMP15chr2:24056788chr16:58071375ENST00000219271010367_41554670.0RepeatNote=Hemopexin 1
TgeneMMP15chr2:24056788chr16:58071375ENST00000219271010416_46154670.0RepeatNote=Hemopexin 2
TgeneMMP15chr2:24056788chr16:58071375ENST00000219271010463_51154670.0RepeatNote=Hemopexin 3
TgeneMMP15chr2:24056788chr16:58071375ENST00000219271010512_55954670.0RepeatNote=Hemopexin 4
TgeneMMP15chr2:24056788chr16:58071375ENST00000219271010132_62554670.0Topological domainExtracellular
TgeneMMP15chr2:24056788chr16:58071375ENST00000219271010647_66954670.0Topological domainCytoplasmic
TgeneMMP15chr2:24056788chr16:58071375ENST00000219271010626_64654670.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATAD2Bchr2:24056788chr16:58071375ENST00000238789-1428943_9745761459.0Coiled coilOntology_term=ECO:0000255
HgeneATAD2Bchr2:24056788chr16:58071375ENST00000238789-14281247_12505761459.0Compositional biasNote=Poly-Ser
HgeneATAD2Bchr2:24056788chr16:58071375ENST00000238789-1428975_10455761459.0DomainBromo


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Fusion Gene Sequence for ATAD2B-MMP15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7340_7340_1_ATAD2B-MMP15_ATAD2B_chr2_24056788_ENST00000238789_MMP15_chr16_58071375_ENST00000219271_length(transcript)=5375nt_BP=2072nt
CCTGCGGCGCTGGAGCCTTGACGCACGGAGCTCGAGAGCGAGAACGGGAGAGAAAGGGGTAGAAATGGCGGCTCCGCTCGGCTCCCGCTG
AGGAGGGCGAAGCCGGCGGAGTGTCTGTGCTGCCGGTCTGCAGCACCGCCCCCGCTTCCCGCACGCCGCCTGCTCACGCCGACTTCCCTT
CCTCTGCCCGGCTCTCTCTTGTGCTCGTCTGCGCTCCGCACGCTCCGGGCCGGCTCGTCTCTCATTGCCCGGCTCGGCTCCGCTGGCCCT
GACTGACCGGCCGGCGGGCCGGCCTTGCTCGGCTCTCCCGGGCGCGGCGTGGACTCCGTCCCCCTGGCTGGACCATGGTGAACACCCGGA
AGAGCTCTCTCCGCCTTCTCGGGTCCAAGTCTCCTGGTCCCGGGCCTGGGCCTGGGGCCGGAGCAGAGCCTGGGGCGACCGGAGGCAGCA
GCCATTTCATCTCCTCTCGGACCCGCTCCTCCAAGACCCGCGCCGCCAGCTGCCCCGCCGCCAAAGCCGGGGGAAGCGGTGGCGCCGGCG
TCACTCTGGATGAGGCCAGGAAAGTTGAAGTTGATGGTAGTTTAAGTGATAGCCACGTATCTCCTCCAGCCAAACGCACTTTGAAACAAC
CTGATTCTGTTTGCAAAGACAAATCAAAATCACGAAGTACTGGTCAGCGAGAGGAATGGAACTTATCAACTGGACAGGCCAGGTTAACTT
CTCAGCCTGGTGCTACATTACCAAATGGACATAGTGGCTTATCCCTTCGAAGCCATCCCCTTCGAGGGGAAAAGAAGGGAGATGGGGACC
TTTCTTGTATAAATGGTGACATGGAAGTCAGAAAAAGTTGTCGTTCCAGGAAAAACAGATTTGAAAGTGTGAACCAGAGTTTGTTATTTG
ATCAACTAGTAAATAGCACTGCTGAAGCTGTACTACAGGAAATGGACAACATTAACATCCGACAGAATCGTCGATCAGGAGAAGTAGAAC
GACTTCGAATGTGGACAGATACAGAATTTGAAAACATGGATATGTATTCAAGAGTGAAAAGGCGAAGAAAGTCACTAAGAAGAAATAGTT
ATGGGATACAAAATCATCATGAAGTTTCTACTGAGGGTGAAGAAGAAGAATCTCAAGAGGAGGATGGAGATATAGAAGTTGAAGAGGCAG
AAGGAGAAGAAAATGATAGACCATATAATTTGAGACAGAGAAAAACAGTGGATCGATACCAAGCACCTCCAATAGTACCAGCTCATCAAA
AAAAGAGGGAAAACACGCTGTTTGATATTCATAGATCTCCAGCAAGAAGAAGCCATATTAGGAGAAAGAAGCATGCCATTCATAGTAGTG
ACACAACTTCTTCTGATGAGGAACGCTTTGAAAGAAGGAAATCAAAGAGCATGGCAAGAGCAAGAAATAGATGTTTGCCTATGAACTTCA
GAGCAGAGGACTTAGCTAGCGGTATTCTCCGAGAACGAGTGAAAGTGGGTGCAAGCTTGGCTGATGTTGATCCAATGAACATTGATAAAT
CAGTACGGTTTGATAGCATAGGTGGATTGAGCCATCATATTCATGCGCTAAAGGAAATGGTAGTATTCCCACTTTTATATCCAGAAATTT
TTGAAAAGTTTAAAATTCAGCCTCCAAGGGGCTGTTTGTTTTATGGCCCTCCTGGCACAGGTAAAACCTTGGTTGCCAGAGCATTAGCTA
ATGAATGCAGCCAAGGAGACAAAAAAGTGGCTTTTTTTATGCGAAAAGGAGCAGATTGTTTGAGCAAGTGGGTTGGTGAATCTGAAAGGC
AACTTAGGCTTCTTTTTGATCAGGCATATTTGATGAGACCTTCTATAATATTTTTTGATGAAATAGATGGATTAGCTCCAGTTCGCTCTA
GCAGACAAGATCAGATCCACAGCTCTATAGTATCAACCCTCCTTGCTCTTATGGATGGATTAGATAATAGGGGTGAAATTGTTGTTATTG
GTGCTACAAACAGACTTGACTCTATAGATCCTGCACTCAGGAGACCTGGTCGTTTTGACAGAGAATTCCTCTTCAACCTGCCTGATCAAA
AGAACTGGCTGCGGCTTTATGGCTACCTGCCTCAGCCCAGCCGCCATATGTCCACCATGCGTTCCGCCCAGATCTTGGCCTCGGCCCTTG
CAGAGATGCAGCGCTTCTACGGGATCCCAGTCACCGGTGTGCTCGACGAAGAGACCAAGGAGTGGATGAAGCGGCCCCGCTGTGGGGTGC
CAGACCAGTTCGGGGTACGAGTGAAAGCCAACCTGCGGCGGCGTCGGAAGCGCTACGCCCTCACCGGGAGGAAGTGGAACAACCACCATC
TGACCTTTAGCATCCAGAACTACACGGAGAAGTTGGGCTGGTACCACTCGATGGAGGCGGTGCGCAGGGCCTTCCGCGTGTGGGAGCAGG
CCACGCCCCTGGTCTTCCAGGAGGTGCCCTATGAGGACATCCGGCTGCGGCGACAGAAGGAGGCCGACATCATGGTACTCTTTGCCTCTG
GCTTCCACGGCGACAGCTCGCCGTTTGATGGCACCGGTGGCTTTCTGGCCCACGCCTATTTCCCTGGCCCCGGCCTAGGCGGGGACACCC
ATTTTGACGCAGATGAGCCCTGGACCTTCTCCAGCACTGACCTGCATGGAAACAACCTCTTCCTGGTGGCAGTGCATGAGCTGGGCCACG
CGCTGGGGCTGGAGCACTCCAGCAACCCCAATGCCATCATGGCGCCGTTCTACCAGTGGAAGGACGTTGACAACTTCAAGCTGCCCGAGG
ACGATCTCCGTGGCATCCAGCAGCTCTACGGTACCCCAGACGGTCAGCCACAGCCTACCCAGCCTCTCCCCACTGTGACGCCACGGCGGC
CAGGCCGGCCTGACCACCGGCCGCCCCGGCCTCCCCAGCCACCACCCCCAGGTGGGAAGCCAGAGCGGCCCCCAAAGCCGGGCCCCCCAG
TCCAGCCCCGAGCCACAGAGCGGCCCGACCAGTATGGCCCCAACATCTGCGACGGGGACTTTGACACAGTGGCCATGCTTCGCGGGGAGA
TGTTCGTGTTCAAGGGCCGCTGGTTCTGGCGAGTCCGGCACAACCGCGTCCTGGACAACTATCCCATGCCCATCGGGCACTTCTGGCGTG
GTCTGCCCGGTGACATCAGTGCTGCCTACGAGCGCCAAGACGGTCGTTTTGTCTTTTTCAAAGGTGACCGCTACTGGCTCTTTCGAGAAG
CGAACCTGGAGCCCGGCTACCCACAGCCGCTGACCAGCTATGGCCTGGGCATCCCCTATGACCGCATTGACACGGCCATCTGGTGGGAGC
CCACAGGCCACACCTTCTTCTTCCAAGAGGACAGGTACTGGCGCTTCAACGAGGAGACACAGCGTGGAGACCCTGGGTACCCCAAGCCCA
TCAGTGTCTGGCAGGGGATCCCTGCCTCCCCTAAAGGGGCCTTCCTGAGCAATGACGCAGCCTACACCTACTTCTACAAGGGCACCAAAT
ACTGGAAATTCGACAATGAGCGCCTGCGGATGGAGCCCGGCTACCCCAAGTCCATCCTGCGGGACTTCATGGGCTGCCAGGAGCACGTGG
AGCCAGGCCCCCGATGGCCCGACGTGGCCCGGCCGCCCTTCAACCCCCACGGGGGTGCAGAGCCCGGGGCGGACAGCGCAGAGGGCGACG
TGGGGGATGGGGATGGGGACTTTGGGGCCGGGGTCAACAAGGACGGGGGCAGCCGCGTGGTGGTGCAGATGGAGGAGGTGGCACGGACGG
TGAACGTGGTGATGGTGCTGGTGCCACTGCTGCTGCTGCTCTGCGTCCTGGGCCTCACCTACGCGCTGGTGCAGATGCAGCGCAAGGGTG
CGCCACGTGTCCTGCTTTACTGCAAGCGCTCGCTGCAGGAGTGGGTCTGACCACCCAGCGCTCCTGCTAACGGTGCTCAGGGGGCGCCTG
TGGTTCTGAGATGGCTCCCAGGGGCTCCCTCCGCCCCCAGGTAGGGGCCCCTCTCAGCCCTCACACACCCTGTCTGCCCCGCCCTCATTA
TTTATGTCCAGGTGTTTGTTTTGTTTTGTTTTTGGCACCTTACTTGACCATTTGTTTCTGTTTCCCCGACTGGGGCAGGGTGTTTAGAAT
TTTCTAAATGTAGTTCTGCTCCAGACAGGGAATTAGGCCCCCATCATCCTCTGGCTTGGCCACAGCCAGGGGAGCAGAGGGGCAGAGGCC
CACATTGGAAGAGCAGCACCTCCTCAGCCTGAACCCCAGGGCTGTAACTGCCAGGCTCTCTTTGCCCAGTTGGAGACTGTCTGGCCCCCC
TGGTCCCCTCCTTCCCAAGTGAGTCTCTCTGGGCCTTAGGAAGAGCCTTCCACCCAGGGGCAGCCCCAGGCCAAAGGGGACCTGGAAGGG
AGGTGGGCCGTGGCCCTTGAGTCCCCATTGAGGCTTGGTTCCTTCCCAATCCAGTGGACTTCGCAGTCCACTTCTGACAGCCTCAGTGAC
CCTGGCTCCTTGTGCCAGAGAACCCAGCCCACCCCCGGCAGCAGCCCCCAGCTCCCACCTCCCCTTGGGCCCACACCTCCTTCCCTCTCT
GGAGAAAGGGCCCTGGGCCTGCCTCACCACGGACCAAAGGGAGTCTGCCAGGGCCCCTCTCCCCAGGGAAGCAGCAGCCTCGCCCCTGGC
AGAGATGCCTCCCTGAGCTAGAACCCTCTGTTCCTTCCCTGTGCCTCCTCCCTCCCTCTCCGACTCACACCACTAGCCTCAGGGGTCTGA
GCTCCAGCTCCTTTGGGCTTCAGCTGCCAGTGTCCTGAGCCCCAGGGAGAGGGGGCTGGTGGGTGCCTAGGCCTGGGCAGTGGATGGCCG
TGAATGGGTGCCCACAGTGTCAGGCACTGGGCATGAGGGGTTCCTCCCCTCCAGCTCCCTGTGCCCCCAGGGTCCTGGGAGGAGAGACAC
TGGTGGGGATAGGCCAGCCGCGCATCAGACTGTGAACCCCACGAAGGAGCCCATTGTGGCCTAAGAGGCTGCCCTCCTGTGCTCAGCCCT
GAGGACAGATGCCTCCTTCCTCTTTTCCTTCCCAAAGCAAGCAAGAGGCCGTGGCTGCTGTGGGAAATGGTACTGTACAGCTGGCTCTAC
TTCCCCATGGCCCTGAGCGAGTGGAGTCTGCCACCCAGGATCCCCAAGGCACTTGAGGGGGAAGGATTCTGCTGGCCTCTGCGAGTGGTT
TCTTGTGCACTGGCACCAAGTGCGGGTCCGGCAGCTTCTGCCCCCTGCAGAACCGGAGAGCCAGCTAAGGGGTGGGGCTGCGGGGGTTCC

>7340_7340_1_ATAD2B-MMP15_ATAD2B_chr2_24056788_ENST00000238789_MMP15_chr16_58071375_ENST00000219271_length(amino acids)=1215AA_BP=600
MTGRRAGLARLSRARRGLRPPGWTMVNTRKSSLRLLGSKSPGPGPGPGAGAEPGATGGSSHFISSRTRSSKTRAASCPAAKAGGSGGAGV
TLDEARKVEVDGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRSTGQREEWNLSTGQARLTSQPGATLPNGHSGLSLRSHPLRGEKKGDGDL
SCINGDMEVRKSCRSRKNRFESVNQSLLFDQLVNSTAEAVLQEMDNINIRQNRRSGEVERLRMWTDTEFENMDMYSRVKRRRKSLRRNSY
GIQNHHEVSTEGEEEESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRYQAPPIVPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSD
TTSSDEERFERRKSKSMARARNRCLPMNFRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIF
EKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSS
RQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKNWLRLYGYLPQPSRHMSTMRSAQILASALA
EMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQA
TPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHA
LGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPV
QPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREA
NLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKY
WKFDNERLRMEPGYPKSILRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGDFGAGVNKDGGSRVVVQMEEVARTV

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Fusion Gene PPI Analysis for ATAD2B-MMP15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATAD2B-MMP15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATAD2B-MMP15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0000786Spontaneous abortion1CTD_human
TgeneC0000822Abortion, Tubal1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC3830362Early Pregnancy Loss1CTD_human
TgeneC4552766Miscarriage1CTD_human