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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FAM105A-DNAH5 (FusionGDB2 ID:HG54491TG1767) |
Fusion Gene Summary for FAM105A-DNAH5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAM105A-DNAH5 | Fusion gene ID: hg54491tg1767 | Hgene | Tgene | Gene symbol | FAM105A | DNAH5 | Gene ID | 54491 | 1767 |
| Gene name | OTU deubiquitinase with linear linkage specificity like | dynein axonemal heavy chain 5 | |
| Synonyms | FAM105A|NET20 | CILD3|DNAHC5|HL1|KTGNR|PCD | |
| Cytomap | ('FAM105A')('DNAH5') 5p15.2 | 5p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inactive ubiquitin thioesterase OTULINLfamily with sequence similarity 105 member Ainactive ubiquitin thioesterase FAM105Aprotein FAM105A | dynein heavy chain 5, axonemalaxonemal beta dynein heavy chain 5ciliary dynein heavy chain 5dynein, axonemal, heavy polypeptide 5 | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000274217, ENST00000506258, | ||
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 9 X 7 X 6=378 |
| # samples | 5 | 8 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/378*10)=-2.24031432933371 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FAM105A [Title/Abstract] AND DNAH5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FAM105A(14602441)-DNAH5(13917365), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | FAM105A-DNAH5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FAM105A-DNAH5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FAM105A-DNAH5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FAM105A-DNAH5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FAM105A | GO:0016579 | protein deubiquitination | 31056421 |
| Fusion gene breakpoints across FAM105A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across DNAH5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LIHC | TCGA-DD-AAVV-01A | FAM105A | chr5 | 14602441 | - | DNAH5 | chr5 | 13917365 | - |
| ChimerDB4 | LIHC | TCGA-DD-AAVV-01A | FAM105A | chr5 | 14602441 | + | DNAH5 | chr5 | 13917365 | - |
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Fusion Gene ORF analysis for FAM105A-DNAH5 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000274217 | ENST00000504001 | FAM105A | chr5 | 14602441 | + | DNAH5 | chr5 | 13917365 | - |
| In-frame | ENST00000274217 | ENST00000265104 | FAM105A | chr5 | 14602441 | + | DNAH5 | chr5 | 13917365 | - |
| intron-3CDS | ENST00000506258 | ENST00000265104 | FAM105A | chr5 | 14602441 | + | DNAH5 | chr5 | 13917365 | - |
| intron-intron | ENST00000506258 | ENST00000504001 | FAM105A | chr5 | 14602441 | + | DNAH5 | chr5 | 13917365 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000274217 | FAM105A | chr5 | 14602441 | + | ENST00000265104 | DNAH5 | chr5 | 13917365 | - | 15171 | 618 | 72 | 13517 | 4481 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000274217 | ENST00000265104 | FAM105A | chr5 | 14602441 | + | DNAH5 | chr5 | 13917365 | - | 0.00021873 | 0.9997813 |
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Fusion Genomic Features for FAM105A-DNAH5 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for FAM105A-DNAH5 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:14602441/chr5:13917365) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FAM105A | chr5:14602441 | chr5:13917365 | ENST00000274217 | + | 5 | 8 | 1_83 | 166 | 357.0 | Region | Required for membrane binding |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 1435_1465 | 325 | 4625.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 3195_3302 | 325 | 4625.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 3426_3491 | 325 | 4625.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 3732_3817 | 325 | 4625.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 4392_4420 | 325 | 4625.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 740_825 | 325 | 4625.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 1980_1987 | 325 | 4625.0 | Nucleotide binding | ATP | |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 2262_2269 | 325 | 4625.0 | Nucleotide binding | ATP | |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 1942_2164 | 325 | 4625.0 | Region | AAA 1 | |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 2224_2443 | 325 | 4625.0 | Region | AAA 2 | |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 2550_2803 | 325 | 4625.0 | Region | AAA 3 | |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 2916_3170 | 325 | 4625.0 | Region | AAA 4 | |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 3185_3482 | 325 | 4625.0 | Region | Stalk | |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 3567_3797 | 325 | 4625.0 | Region | AAA 5 | |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 4012_4226 | 325 | 4625.0 | Region | AAA 6 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FAM105A | chr5:14602441 | chr5:13917365 | ENST00000274217 | + | 5 | 8 | 128_356 | 166 | 357.0 | Domain | OTU |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 284_305 | 325 | 4625.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | DNAH5 | chr5:14602441 | chr5:13917365 | ENST00000265104 | 6 | 79 | 1_1941 | 325 | 4625.0 | Region | Stem |
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Fusion Gene Sequence for FAM105A-DNAH5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >28313_28313_1_FAM105A-DNAH5_FAM105A_chr5_14602441_ENST00000274217_DNAH5_chr5_13917365_ENST00000265104_length(transcript)=15171nt_BP=618nt CCCGCCCTCCCCAGCCCGCCTCAGGGAAGCGAGCCCGGGCGCCGGCGGGCGGCCGTCGCGTCTGACAGACCACTGCAGACCACGGGCCGA GGCCCAGCGCCCGTCCGCAGCGCGGCCGGCATGGCGGCGACAAGGAGCCCCACGCGGGCAAGGGAGCGGGAGCGGTCTGGCGCTCCCGCC GCAGGAAGTGACCAAGTTCACTCCTGGATGCTAGCTACAAGCCAAGCCTTAGACACTGTCTGGAGAATGGCAAAAGGCTTTGTGATGTTG GCAGTTTCATTTCTGGTGGCTGCCATCTGCTACTTCCGGAGGCTACATTTATATTCAGGGCACAAGCTGAAATGGTGGATTGGATATCTG CAGAGAAAATTCAAAAGGAACCTCAGTGTGGAGGCAGAGGTTGATTTACTCAGTTATTGTGCAAGAGAATGGAAAGGAGAGACACCCCGT AACAAGCTGATGAGGAAGGCTTATGAGGAGCTATTTTGGCGGCATCACATTAAATGTGTTCGACAAGTAAGGAGAGATAACTATGATGCT CTCAGATCAGTGTTATTTCAGATATTCAGCCAGGGCATCTCTTTTCCATCATGGATGAAAGAAAAGGACATTGTTAAGACTTGGCGGGAG ATGGATATTCGAATCACTGATGCAACTAATGAAGCAAAGGACAATGTGAAATACTTGTATACACTTGAAAAATGTTGTGACCCTTTGTAC AGCAGTGATCCCCTATCCATGATGGATGCTATTCCTACACTTATAAATGCAATTAAAATGATCTATAGTATCTCTCATTACTATAATACC TCTGAGAAGATCACATCTCTGTTTGTAAAGGTGACAAATCAGATTATATCTGCATGTAAAGCCTATATTACCAATAATGGAACCGCTTCC ATCTGGAACCAGCCACAGGATGTTGTTGAAGAAAAAATACTATCTGCGATTAAACTGAAACAGGAATACCAGCTCTGCTTTCACAAGACA AAACAAAAGCTTAAACAAAATCCAAATGCAAAACAATTTGATTTTAGCGAGATGTATATTTTTGGAAAATTCGAAACTTTTCACCGACGC CTTGCCAAGATAATAGACATCTTTACAACCCTCAAGACGTATTCAGTCCTGCAAGATTCCACAATTGAAGGGCTGGAAGACATGGCCACT AAATACCAGGGCATTGTGGCAACCATAAAGAAAAAGGAATACAATTTCCTAGACCAGCGGAAAATGGATTTTGACCAAGATTACGAAGAG TTTTGCAAGCAGACTAATGACCTTCATAACGAGTTGCGGAAGTTCATGGATGTTACATTTGCAAAGATTCAAAACACAAATCAAGCTCTA AGAATGTTGAAGAAATTTGAAAGATTGAATATACCTAATCTTGGTATTGATGACAAATATCAACTTATCCTTGAGAACTATGGGGCTGAC ATTGATATGATTTCAAAGCTGTATACAAAGCAGAAATACGATCCTCCTCTGGCTCGAAACCAGCCTCCCATCGCTGGAAAGATTTTGTGG GCCCGCCAGCTCTTCCATAGGATTCAGCAGCCCATGCAGCTTTTCCAGCAGCACCCAGCTGTGCTAAGCACGGCAGAAGCCAAACCTATA ATTCGCAGTTACAACAGGATGGCCAAGGTCCTCCTGGAGTTTGAGGTCCTCTTCCACAGGGCGTGGCTTCGGCAAATTGAAGAAATTCAT GTAGGTCTTGAGGCTTCATTATTGGTGAAGGCTCCAGGCACAGGGGAATTGTTTGTAAACTTTGACCCTCAGATATTAATCTTATTTAGA GAAACAGAGTGCATGGCCCAGATGGGTCTGGAAGTCTCTCCACTGGCAACTTCCCTCTTCCAGAAACGAGATAGATACAAAAGGAACTTC AGTAACATGAAGATGATGCTAGCTGAATATCAGAGAGTGAAGTCAAAAATACCTGCTGCCATTGAGCAATTGATTGTCCCTCACTTGGCC AAAGTGGATGAAGCTCTCCAACCTGGCTTGGCTGCACTGACCTGGACATCACTGAATATTGAGGCTTATTTAGAAAACACTTTTGCAAAG ATCAAGGACCTGGAGTTGCTGCTTGACAGGGTCAATGATTTGATTGAGTTCCGCATTGATGCCATTCTAGAAGAAATGAGCAGCACGCCT CTTTGTCAGCTTCCCCAGGAGGAGCCACTAACCTGTGAAGAGTTTCTCCAAATGACAAAGGATCTTTGTGTAAATGGTGCACAAATACTA CATTTTAAAAGCTCATTAGTGGAGGAGGCAGTCAATGAGCTTGTAAATATGTTGCTGGATGTGGAAGTTTTATCTGAAGAAGAAAGTGAA AAAATATCCAATGAGAATAGTGTTAATTACAAAAATGAAAGTTCAGCAAAAAGAGAAGAAGGAAATTTTGACACCTTGACATCATCTATT AATGCCAGGGCCAATGCCCTGCTTTTGACGACAGTCACGAGGAAAAAGAAAGAAACTGAGATGTTAGGGGAAGAAGCCCGCGAGTTACTC TCTCATTTCAACCATCAGAACATGGATGCTCTTCTGAAAGTTACAAGGAATACACTAGAGGCCATTCGCAAACGTATTCATTCCTCTCAC ACAATTAACTTCCGGGACAGTAACAGTGCCTCTAACATGAAGCAGAACAGTTTGCCCATTTTCCGGGCAAGCGTCACTCTGGCCATTCCC AACATCGTCATGGCCCCTGCCCTGGAAGATGTACAGCAGACCCTGAACAAAGCCGTGGAGTGCATCATCAGTGTCCCTAAGGGGGTCAGA CAGTGGAGCAGTGAACTGTTGTCCAAGAAAAAGATACAAGAAAGAAAAATGGCTGCTTTGCAGAGTAATGAAGACAGTGATTCTGATGTT GAAATGGGAGAAAATGAACTTCAAGATACCTTGGAGATAGCATCTGTAAATTTACCCATTCCCGTGCAAACCAAGAACTATTATAAGAAT GTTTCTGAAAACAAAGAGATTGTAAAATTAGTTTCTGTGCTTAGCACAATTATCAACTCCACCAAAAAGGAAGTTATTACATCCATGGAT TGCTTCAAACGCTACAATCACATTTGGCAAAAGGGAAAAGAAGAAGCCATTAAGACATTTATTACACAGAGCCCCTTGCTTTCTGAATTT GAGTCCCAGATTCTCTATTTCCAAAACCTAGAGCAGGAAATTAATGCTGAGCCTGAATATGTCTGTGTGGGTTCCATTGCTCTGTACACA GCTGACTTGAAGTTCGCCCTGACTGCTGAGACAAAGGCCTGGATGGTTGTCATTGGACGCCACTGTAACAAAAAATACCGGAGTGAGATG GAAAACATTTTTATGCTTATTGAAGAATTCAATAAGAAACTAAATCGTCCAATTAAGGACCTAGATGATATTCGGATTGCAATGGCAGCG CTGAAAGAAATAAGGGAGGAGCAAATCTCCATTGACTTTCAAGTAGGACCTATTGAGGAATCTTATGCCCTGCTTAACAGATATGGACTT CTGATAGCAAGGGAAGAGATAGACAAAGTTGATACACTGCACTATGCTTGGGAGAAGCTGCTGGCACGTGCTGGCGAAGTCCAGAATAAA TTAGTCTCACTGCAGCCCAGTTTCAAGAAAGAGCTTATTAGTGCTGTGGAGGTATTCCTCCAAGATTGTCACCAGTTTTATCTGGACTAT GATTTGAATGGTCCAATGGCTAGCGGCTTGAAGCCCCAGGAAGCCAGTGACAGGCTTATCATGTTTCAGAATCAATTTGATAATATCTAT CGGAAATACATCACATATACTGGAGGAGAGGAGCTTTTTGGCCTGCCAGCTACACAGTATCCTCAGCTTCTTGAAATAAAGAAGCAACTA AATCTTCTACAGAAAATATATACTCTGTACAACAGTGTCATAGAAACTGTAAATAGCTATTATGATATTCTTTGGTCAGAGGTGAATATT GAAAAAATTAACAATGAACTCTTAGAATTCCAGAACAGATGTCGAAAGCTTCCCCGGGCCTTGAAGGACTGGCAGGCTTTTTTGGACCTG AAGAAGATCATTGATGATTTCAGCGAGTGTTGCCCGCTGCTGGAATACATGGCCAGTAAAGCCATGATGGAGCGGCACTGGGAAAGGATA ACCACCCTCACCGGGCACAGTCTGGATGTGGGGAATGAAAGCTTTAAGTTAAGAAATATCATGGAGGCACCTCTTCTGAAATATAAAGAG GAAATAGAGGACATCTGTATCAGTGCGGTGAAAGAGAGAGACATTGAGCAAAAGCTGAAGCAAGTGATTAATGAATGGGACAATAAAACA TTCACCTTCGGCAGCTTTAAAACCCGTGGAGAGCTCCTCTTGAGAGGAGACAGTACCTCGGAAATCATCGCCAACATGGAGGACAGCTTG ATGTTGCTGGGATCCCTACTGAGCAACAGGTACAATATGCCATTCAAAGCCCAGATTCAAAAATGGGTGCAGTACCTTTCCAACTCAACA GACATCATCGAGAGCTGGATGACGGTGCAAAACCTGTGGATTTATTTAGAAGCTGTCTTTGTGGGAGGAGACATTGCCAAGCAGCTGCCC AAGGAAGCCAAGCGGTTTTCTAACATAGATAAATCTTGGGTGAAGATCATGACTCGGGCACATGAAGTGCCCAGTGTAGTCCAGTGCTGT GTTGGAGATGAGACCCTGGGGCAGCTGTTACCACACTTGCTGGACCAGTTGGAAATATGCCAGAAATCCCTTACTGGGTACTTGGAGAAA AAACGACTGTGCTTTCCTCGGTTTTTCTTCGTCTCAGATCCTGCCCTTCTAGAGATTCTGGGGCAGGCGTCGGACTCCCACACTATACAG GCCCATTTGCTGAATGTGTTTGACAACATTAAATCTGTCAAGTTCCACGAAAAGATCTATGATCGAATTCTGTCAATTTCCTCTCAAGAG GGTGAGACGATTGAATTGGATAAACCTGTCATGGCAGAGGGCAATGTGGAAGTTTGGCTTAATTCTCTTTTGGAAGAATCTCAGTCCTCA TTGCATCTTGTGATTCGCCAGGCAGCCGCAAATATTCAAGAAACAGGTTTCCAACTAACTGAATTTCTTTCATCCTTCCCTGCTCAGGTT GGATTATTAGGAATTCAGATGATATGGACACGGGATTCAGAAGAAGCCCTTAGAAATGCCAAGTTTGATAAAAAAATCATGCAGAAAACT AATCAGGCTTTCCTGGAGCTACTCAATACATTGATAGACGTCACCACGAGGGATCTGAGTTCCACGGAACGAGTGAAATACGAGACTCTG ATTACTATTCATGTGCACCAAAGGGATATCTTTGATGACCTGTGTCATATGCATATCAAGAGTCCCATGGACTTTGAGTGGCTGAAACAG TGCAGATTTTACTTTAACGAAGATTCTGACAAGATGATGATTCACATCACAGATGTGGCGTTCATATACCAGAATGAATTTTTAGGCTGC ACTGACAGGCTTGTAATAACTCCACTTACAGACAGATGTTACATCACGCTGGCTCAAGCTCTGGGAATGAGCATGGGGGGAGCCCCTGCT GGACCTGCAGGCACAGGCAAAACAGAAACCACTAAAGACATGGGACGATGCCTCGGGAAATACGTCGTGGTTTTCAATTGTTCAGACCAG ATGGATTTCCGAGGACTTGGACGGATTTTTAAGGGACTGGCACAGTCTGGATCCTGGGGTTGTTTTGATGAATTTAACCGTATTGATCTA CCAGTTCTCTCGGTTGCAGCCCAGCAAATTTCCATTATTCTGACATGTAAAAAGGAGCACAAAAAGTCTTTTATCTTTACTGATGGAGAT AATGTGACTATGAACCCTGAATTTGGGCTTTTCTTAACCATGAATCCTGGCTATGCCGGACGGCAGGAACTCCCTGAAAACTTGAAGATT AATTTCCGCTCAGTGGCCATGATGGTGCCTGACCGTCAGATTATCATAAGGGTGAAGTTGGCTAGTTGTGGCTTCATTGACAACGTTGTT TTGGCCAGGAAGTTTTTCACGCTCTACAAACTGTGTGAGGAGCAGCTTTCTAAGCAGGTTCATTATGACTTTGGCCTGCGTAACATTCTG TCAGTTCTTCGGACCTTGGGAGCAGCAAAAAGAGCCAATCCAATGGATACGGAGTCCACGATTGTCATGCGTGTACTACGGGACATGAAT CTTTCTAAACTGATTGATGAGGATGAACCCTTGTTTTTGAGTTTGATTGAAGATCTCTTTCCAAATATTCTTCTGGACAAGGCAGGTTAC CCTGAACTGGAAGCAGCAATTAGTAGACAGGTTGAAGAAGCTGGTTTAATCAACCATCCTCCTTGGAAACTGAAGGTCATCCAGCTATTC GAAACGCAGAGAGTGCGACATGGGATGATGACTCTGGGGCCCAGTGGGGCTGGGAAGACCACCTGCATCCACACCTTGATGAGAGCCATG ACAGATTGTGGAAAACCACATCGGGAAATGAGGATGAATCCCAAAGCGATTACTGCCCCACAGATGTTTGGTCGGCTGGACGTTGCCACA AATGACTGGACTGATGGGATATTTTCTACGCTTTGGAGGAAAACATTAAGAGCAAAGAAAGGGGAACATATCTGGATAATTCTTGATGGT CCAGTAGATGCCATCTGGATTGAAAATCTGAATTCTGTTTTGGATGATAACAAAACTCTAACCCTTGCCAATGGTGATCGGATTCCCATG GCTCCAAACTGCAAGATCATTTTCGAGCCTCATAACATTGACAATGCTTCTCCTGCCACCGTCTCAAGAAATGGAATGGTTTTCATGAGC TCTTCTATCCTTGATTGGAGTCCTATTCTTGAGGGTTTTCTTAAGAAACGCTCACCTCAAGAAGCAGAAATTCTTCGTCAGCTGTACACC GAGTCTTTCCCAGACTTGTATCGCTTCTGTATCCAGAACTTAGAATACAAGATGGAGGTGCTGGAGGCCTTTGTCATCACACAGAGCATT AACATGCTTCAAGGCCTGATTCCTCTGAAGGAGCAAGGCGGGGAGGTGAGCCAGGCTCACCTGGGGCGGCTGTTCGTGTTCGCGCTGCTG TGGAGCGCGGGGGCGGCGCTGGAGCTGGACGGACGGCGCCGCCTGGAGCTCTGGCTGCGCTCTCGGCCCACAGGGACGCTGGAGCTGCCG CCGCCAGCGGGGCCCGGGGACACCGCCTTCGACTACTATGTGGCGCCCGATGGTACATGGACGCACTGGAACACGCGTACCCAGGAATAC CTGTATCCGTCTGATACCACCCCAGAGTATGGTTCTATTCTGGTGCCAAATGTTGACAATGTGAGGACTGACTTTCTAATTCAAACCATT GCTAAACAGGGCAAGGCTGTGCTATTAATTGGTGAACAAGGAACAGCCAAAACAGTAATAATTAAAGGATTTATGTCAAAATATGATCCT GAATGTCACATGATCAAGAGTCTGAATTTTTCTTCTGCAACCACCCCACTGATGTTCCAGAGGACGATAGAGAGCTATGTGGATAAACGA ATGGGTACAACATATGGCCCTCCTGCGGGAAAGAAGATGACTGTTTTTATTGATGATGTGAATATGCCAATAATCAATGAGTGGGGAGAT CAGGTTACGAATGAGATAGTGCGACAGCTGATGGAACAAAATGGATTCTATAATCTAGAGAAGCCTGGGGAGTTCACCAGCATCGTGGAC ATCCAGTTTTTGGCAGCCATGATCCATCCTGGTGGTGGACGCAATGACATACCCCAAAGACTCAAGAGGCAGTTCTCTATATTTAATTGC ACGTTGCCCTCTGAAGCTTCTGTGGACAAGATCTTTGGTGTGATTGGGGTAGGCCACTACTGTACTCAGAGGGGTTTCTCAGAAGAAGTG AGAGATTCTGTGACAAAATTGGTGCCTCTGACACGCCGACTATGGCAGATGACCAAGATTAAAATGCTTCCTACCCCTGCAAAATTCCAT TATGTGTTTAACCTACGAGATCTTTCTCGGGTCTGGCAGGGAATGCTGAACACTACTTCAGAGGTCATCAAGGAACCAAATGATCTGTTA AAGCTGTGGAAGCATGAGTGTAAACGTGTTATAGCTGACCGTTTCACAGTGTCCAGTGATGTGACCTGGTTTGATAAGGCTTTAGTAAGT TTGGTAGAGGAGGAGTTTGGTGAAGAGAAAAAACTCTTGGTGGATTGTGGAATTGACACATATTTTGTGGATTTCTTGAGAGATGCACCT GAAGCTGCAGGTGAAACATCTGAAGAGGCTGATGCTGAAACACCTAAAATTTATGAGCCAATTGAATCTTTTAGTCACCTAAAAGAGCGT CTGAATATGTTCCTGCAGCTCTATAATGAGAGCATCCGTGGCGCCGGCATGGACATGGTGTTCTTTGCAGATGCCATGGTTCACTTAGTC AAGATCTCTCGTGTCATTCGTACTCCTCAGGGAAATGCCCTCCTGGTCGGGGTGGGCGGATCAGGAAAGCAGAGCCTGACGAGGTTGGCT TCATTCATTGCTGGCTACGTTTCCTTCCAGATCACTCTGACGAGATCCTACAACACATCAAATCTGATGGAAGATCTGAAGGTTTTGTAT CGAACAGCTGGTCAGCAAGGCAAAGGAATCACTTTTATTTTCACAGACAATGAGATTAAAGATGAGTCATTTTTGGAATATATGAACAAT GTTTTATCATCAGGTGAGGTCTCTAACCTATTTGCTCGAGATGAAATTGATGAAATTAATAGCGACCTGGCATCAGTCATGAAAAAAGAA TTCCCCAGGTGCCTTCCTACCAATGAGAACCTGCACGACTACTTCATGAGTCGGGTCCGACAGAACCTTCATATTGTGCTCTGCTTCTCG CCAGTGGGGGAGAAATTTCGAAACAGAGCTTTGAAGTTCCCTGCCCTAATTTCAGGATGCACAATTGACTGGTTCAGCCGATGGCCCAAA GATGCTTTAGTTGCTGTGTCTGAACACTTCCTCACTTCCTATGATATTGACTGCAGTTTGGAAATCAAGAAGGAGGTGGTCCAATGCATG GGCTCCTTCCAGGATGGGGTGGCTGAGAAGTGTGTTGATTATTTTCAGAGATTCCGACGTTCTACCCACGTGACGCCCAAATCATACCTC TCCTTTATTCAGGGCTATAAGTTCATATATGGAGAAAAGCATGTGGAGGTGCGGACCCTGGCCAACAGAATGAATACTGGATTGGAAAAG CTCAAAGAAGCTTCAGAGTCTGTTGCAGCCTTGAGTAAAGAACTGGAAGCGAAAGAAAAGGAGCTACAAGTGGCCAACGATAAAGCCGAC ATGGTCTTAAAAGAAGTGACAATGAAAGCACAGGCTGCTGAAAAGGTCAAGGCTGAGGTACAGAAGGTGAAGGACAGGGCCCAGGCCATT GTGGACAGCATCTCTAAAGACAAAGCCATTGCTGAAGAAAAACTGGAAGCAGCAAAACCAGCTTTAGAAGAGGCAGAAGCTGCATTGCAG ACCATCAGGCCTTCGGACATCGCCACTGTTCGCACGTTGGGCCGCCCCCCTCACCTCATCATGCGGATCATGGATTGCGTACTGCTGCTG TTTCAAAGGAAAGTCAGTGCTGTGAAAATTGACCTGGAAAAAAGCTGTACCATGCCCTCCTGGCAGGAATCCTTAAAATTGATGACTGCA GGGAACTTTTTACAGAACTTACAGCAATTCCCAAAAGACACAATCAATGAAGAGGTGATAGAATTTTTGAGTCCTTACTTTGAAATGCCT GACTATAACATCGAAACTGCTAAACGCGTATGTGGAAATGTAGCTGGTCTTTGTTCCTGGACGAAAGCTATGGCTTCCTTCTTTTCTATA AACAAAGAAGTACTGCCTCTGAAGGCCAACTTGGTGGTGCAAGAGAATCGCCATCTCCTGGCCATGCAGGATCTGCAGAAAGCCCAGGCC GAGTTGGATGACAAGCAGGCGGAACTTGACGTGGTGCAGGCTGAGTATGAACAGGCCATGACTGAAAAGCAGACCTTGCTTGAAGATGCA GAGCGATGCAGACACAAGATGCAGACAGCTTCCACGCTCATCAGTGGCTTGGCAGGTGAAAAAGAAAGATGGACAGAGCAAAGCCAAGAG TTTGCTGCACAAACTAAAAGACTTGTAGGGGATGTACTGTTGGCTACAGCTTTTCTATCTTATTCTGGTCCATTTAACCAAGAGTTTCGT GATCTTCTGTTAAATGACTGGCGGAAGGAAATGAAAGCCCGGAAAATTCCATTTGGAAAGAACCTAAATCTCAGTGAGATGTTGATTGAT GCTCCTACTATTAGTGAATGGAACCTCCAAGGTCTGCCAAATGATGACTTGTCCATTCAAAATGGAATTATTGTCACGAAGGCATCTCGT TACCCTTTGTTAATTGATCCACAGACTCAAGGCAAGATCTGGATTAAAAATAAAGAAAGCCGAAATGAACTCCAGATCACGTCTTTAAAT CACAAGTACTTCAGAAACCACCTGGAAGACAGCCTTTCTCTTGGAAGGCCTTTGCTTATTGAAGATGTTGGAGAGGAACTAGATCCAGCA CTAGATAATGTTTTGGAAAGAAACTTCATTAAAACTGGGTCTACCTTTAAGGTGAAAGTTGGTGACAAGGAAGTAGATGTGTTGGATGGC TTTAGACTCTACATTACCACCAAATTGCCTAACCCAGCCTACACCCCTGAGATAAGTGCCCGTACCTCCATCATTGACTTCACTGTCACC ATGAAAGGTCTAGAAGATCAGTTACTGGGGAGGGTCATTCTCACAGAGAAGCAGGAATTGGAGAAAGAAAGAACTCATCTGATGGAAGAT GTAACTGCAAACAAAAGAAGGATGAAGGAACTAGAAGATAACTTGCTTTACCGCCTGACAAGTACCCAGGGGTCCCTGGTAGAAGATGAA AGTCTCATTGTCGTGCTGAGTAACACAAAAAGGACAGCCGAGGAGGTGACACAGAAGCTAGAAATTTCTGCTGAGACAGAAGTTCAAATT AACTCAGCCCGGGAGGAATACAGACCTGTGGCTACGCGGGGCAGCATCCTCTACTTCCTCATTACTGAGATGCGCTTGGTTAATGAGATG TATCAGACTTCGCTTCGCCAGTTTCTGGGCTTATTTGACCTTTCCTTAGCCAGGTCTGTCAAGAGCCCGATTACAAGCAAGAGGATTGCT AATATCATCGAGCACATGACCTACGAGGTTTATAAGTATGCTGCCCGAGGGCTGTACGAGGAGCACAAATTCCTGTTCACCTTGTTGCTT ACCCTAAAGATTGACATCCAGAGGAACCGAGTCAAGCATGAAGAGTTTCTCACTCTTATTAAAGGAGGTGCCTCATTAGACCTTAAAGCT TGTCCTCCAAAACCATCAAAATGGATCCTGGACATAACATGGCTGAATTTGGTGGAACTTAGCAAACTCAGACAGTTTTCAGATGTCCTT GACCAGATATCGAGAAATGAGAAAATGTGGAAAATTTGGTTTGATAAGGAAAACCCGGAGGAGGAACCTCTTCCAAATGCCTATGATAAA TCTCTTGACTGCTTCAGACGTCTTCTCCTTATTAGATCCTGGTGTCCTGACAGAACCATCGCCCAGGCCCGCAAGTACATCGTGGACTCC ATGGGAGAAAAATATGCCGAAGGTGTTATTTTAGACTTGGAGAAGACGTGGGAGGAATCTGATCCACGGACGCCACTCATCTGTCTCCTG TCTATGGGCTCAGACCCCACAGATTCCATCATTGCCTTGGGGAAGAGATTAAAAATAGAAACCCGTTATGTGTCCATGGGCCAGGGCCAG GAAGTCCATGCTCGGAAGCTCTTGCAGCAGACCATGGCGAACGGAGGATGGGCACTTCTGCAGAACTGCCATCTGGGACTTGATTTCATG GATGAGCTGATGGACATAATCATAGAAACTGAGCTTGTACATGATGCGTTCCGCCTCTGGATGACCACCGAGGCTCATAAGCAGTTTCCC ATTACACTCCTTCAGATGTCCATTAAATTTGCCAACGATCCTCCACAAGGACTCCGGGCAGGACTGAAAAGAACATATAGTGGTGTCAGC CAAGACCTGCTGGACGTGAGCTCTGGGTCCCAGTGGAAGCCCATGCTGTACGCAGTGGCTTTCCTGCACTCCACTGTCCAGGAGAGGCGC AAGTTCGGTGCCCTGGGGTGGAATATCCCCTACGAATTTAACCAAGCGGACTTTAATGCCACTGTGCAGTTCATCCAAAACCACTTGGAT GACATGGATGTCAAAAAGGGTGTCTCCTGGACCACCATCCGCTACATGATAGGAGAGATTCAATATGGAGGCAGAGTCACTGACGACTAT GATAAGAGATTGTTGAACACATTTGCTAAGGTTTGGTTCAGTGAAAATATGTTTGGACCAGATTTCAGTTTTTACCAAGGATACAATATT CCAAAATGCAGCACAGTGGATAACTATCTTCAGTATATCCAGAGTTTGCCTGCCTATGACAGCCCTGAGGTGTTTGGGCTGCACCCCAAT GCTGACATCACCTACCAGAGCAAGCTGGCCAAGGACGTGCTGGACACCATCCTAGGCATCCAACCCAAGGACACCTCTGGTGGAGGGGAT GAGACCCGGGAGGCGGTGGTGGCCCGGCTGGCTGATGATATGCTGGAGAAGCTGCCCCCAGACTATGTCCCCTTTGAAGTAAAAGAGAGG CTGCAGAAGATGGGGCCATTCCAGCCTATGAACATTTTCCTCAGGCAGGAAATAGACAGAATGCAAAGGGTACTCAGCCTTGTCCGCAGC ACCCTCACTGAGCTGAAACTTGCTATTGATGGCACCATCATCATGAGCGAAAATCTGCGAGATGCATTGGATTGCATGTTTGATGCTAGA ATCCCTGCTTGGTGGAAAAAAGCTTCTTGGATTTCTAGTACACTGGGTTTCTGGTTTACTGAACTTATAGAAAGAAACAGCCAGTTTACC TCGTGGGTTTTCAATGGCCGACCTCACTGCTTTTGGATGACGGGTTTTTTTAACCCCCAGGGATTTTTAACTGCAATGCGACAGGAAATA ACTCGGGCCAACAAAGGCTGGGCTCTGGACAATATGGTGCTTTGCAATGAAGTCACCAAATGGATGAAGGACGACATTTCTGCCCCTCCC ACAGAGGGTGTCTATGTCTATGGCTTATATCTTGAAGGTGCTGGCTGGGACAAGAGGAACATGAAACTCATTGAATCAAAGCCAAAAGTG CTCTTTGAGTTGATGCCTGTCATAAGGATTTATGCAGAAAACAATACTTTACGAGATCCTCGGTTTTACTCCTGTCCCATCTATAAGAAG CCAGTTCGAACGGACTTGAACTACATTGCCGCTGTGGATCTCAGGACAGCCCAGACCCCTGAACACTGGGTGCTCCGTGGGGTTGCCCTT CTGTGTGATGTCAAGTAACATGTGGGGAGTGTCCCCACCCAATGCTTTGGAAAATGCAAGATCTAAATTATTGTAACCTTTATTTCTGTA TGACTGCTGGACAGTGTATGTTAGGTCGTTTATGCAATTAATGAGCTGCATAGGTTTTCCCCACTCCTTAATTGGATGCTTATATTTTAC TTGTTTCATCATTAGTGACCAATGTCTGAGTTTGTTGAAAATGTTATTTAGTGATATAAAAGTAAATTTACAGCATCCTAATGAAGTGTG GCCCTCAAATCCACAGTAGTATATTTTCTTCTTACTTCGCTCCGAAGACTGACTAGGGTAAGCAGACAGTATTTCTCTGGGAGGAATTAT TCTTCTGTTAACGTGGCCTGGTAACAGCCAAGTTCTTGAAGGTAACAGGGCAAGTCTGTGCTGATTTTGCTTCTATTGCCTTTCGTATTT AGGTCAAGTTAAGAGACTTATTTTCAGGGTTTCAAGCAGCCAATTAAAAATACCTTTTAAAAAATAGAAGGAAATAGAAGAATGGATTAA GAATGTAAATAGAAAATTTATGTAAACATAGAGAATAAACGTAGAACAATGCTTAAGCCTACTTATAATTAATAATGAAATACTAATTGA TAATTCTTATAATAAAAATTAAAGCTAAAAGTAAATGATAGCATGCTCTCAGTAAAACTGATCCACTCACAAATTGCTGGAGCAATGTAA ATCAACCCAACCTTTTTGTAAAATGATTAAATACAGAAAGAGCCATAAAAATATTCACACCCTTGGATCTTTGTTTTCTCTACATCAAGG AAACAATTTAAAAGACTGAAAACAGTCTATATAAAATTGCATTTAATAACAGAAAAAAATGGAAAAATCATAAATATTCAATAGTCAGGC TATGGTTAAGGAAATTAAGAGATATTTGGCAACCATAAAAAACAATTTTGAAGATTCCATAATATGAAATGGTAGACCCAGACTGTTAAG TGAAAGATTTAGTTTACAAAATATTGAGCACACTGTGATTATAACAGCAAATATATTTGCATGTGGACAAAGATTAGATGGCAAGATAGA AAAATAAGAACAGATGTGATAGCAAGAATTATAGTTGGCTTGAAAAAATGTGATGATCAGGAGAAAAAATAAAAAAAGGGTAGAAATATT AGACGGTGCGTAGGGACTTTCTATGGACTTTTATTAATTAGGAAACATTATCAAAGGAACTTTTCACGTATTTTTCTTTAAATTCTGGTT AGATGTTATTAATAATTCTTCATCTAACCTACTGACTAGAAAATATAGTCAGTACTAAATTAGAATTGTGGTTTATAAACTTTTGGTTAG CTCTGGATCTGTATAACTGCATTTTTTTGGATAAACAGTTTTTGGTAGGTGGATACCGGGAGACAAGTGTGGGTCCCTCTCACTGGGCTT CATTCTGTGGACCAGGATCATTATTTCATGCTCATGATCATGAGAGTTAGGACTGAGTGGCTCCTGTGACTCCCACCATCTTAGATGATA CTGTTTTCTTGTGAGTTCTTTCTTTTGGTGTGGATTAGTATATCAGTTGATTTGTGTGAATTGTGGTGAAACAATCATTTCATTTTGAAA >28313_28313_1_FAM105A-DNAH5_FAM105A_chr5_14602441_ENST00000274217_DNAH5_chr5_13917365_ENST00000265104_length(amino acids)=4481AA_BP=182 MQTTGRGPAPVRSAAGMAATRSPTRARERERSGAPAAGSDQVHSWMLATSQALDTVWRMAKGFVMLAVSFLVAAICYFRRLHLYSGHKLK WWIGYLQRKFKRNLSVEAEVDLLSYCAREWKGETPRNKLMRKAYEELFWRHHIKCVRQVRRDNYDALRSVLFQIFSQGISFPSWMKEKDI VKTWREMDIRITDATNEAKDNVKYLYTLEKCCDPLYSSDPLSMMDAIPTLINAIKMIYSISHYYNTSEKITSLFVKVTNQIISACKAYIT NNGTASIWNQPQDVVEEKILSAIKLKQEYQLCFHKTKQKLKQNPNAKQFDFSEMYIFGKFETFHRRLAKIIDIFTTLKTYSVLQDSTIEG LEDMATKYQGIVATIKKKEYNFLDQRKMDFDQDYEEFCKQTNDLHNELRKFMDVTFAKIQNTNQALRMLKKFERLNIPNLGIDDKYQLIL ENYGADIDMISKLYTKQKYDPPLARNQPPIAGKILWARQLFHRIQQPMQLFQQHPAVLSTAEAKPIIRSYNRMAKVLLEFEVLFHRAWLR QIEEIHVGLEASLLVKAPGTGELFVNFDPQILILFRETECMAQMGLEVSPLATSLFQKRDRYKRNFSNMKMMLAEYQRVKSKIPAAIEQL IVPHLAKVDEALQPGLAALTWTSLNIEAYLENTFAKIKDLELLLDRVNDLIEFRIDAILEEMSSTPLCQLPQEEPLTCEEFLQMTKDLCV NGAQILHFKSSLVEEAVNELVNMLLDVEVLSEEESEKISNENSVNYKNESSAKREEGNFDTLTSSINARANALLLTTVTRKKKETEMLGE EARELLSHFNHQNMDALLKVTRNTLEAIRKRIHSSHTINFRDSNSASNMKQNSLPIFRASVTLAIPNIVMAPALEDVQQTLNKAVECIIS VPKGVRQWSSELLSKKKIQERKMAALQSNEDSDSDVEMGENELQDTLEIASVNLPIPVQTKNYYKNVSENKEIVKLVSVLSTIINSTKKE VITSMDCFKRYNHIWQKGKEEAIKTFITQSPLLSEFESQILYFQNLEQEINAEPEYVCVGSIALYTADLKFALTAETKAWMVVIGRHCNK KYRSEMENIFMLIEEFNKKLNRPIKDLDDIRIAMAALKEIREEQISIDFQVGPIEESYALLNRYGLLIAREEIDKVDTLHYAWEKLLARA GEVQNKLVSLQPSFKKELISAVEVFLQDCHQFYLDYDLNGPMASGLKPQEASDRLIMFQNQFDNIYRKYITYTGGEELFGLPATQYPQLL EIKKQLNLLQKIYTLYNSVIETVNSYYDILWSEVNIEKINNELLEFQNRCRKLPRALKDWQAFLDLKKIIDDFSECCPLLEYMASKAMME RHWERITTLTGHSLDVGNESFKLRNIMEAPLLKYKEEIEDICISAVKERDIEQKLKQVINEWDNKTFTFGSFKTRGELLLRGDSTSEIIA NMEDSLMLLGSLLSNRYNMPFKAQIQKWVQYLSNSTDIIESWMTVQNLWIYLEAVFVGGDIAKQLPKEAKRFSNIDKSWVKIMTRAHEVP SVVQCCVGDETLGQLLPHLLDQLEICQKSLTGYLEKKRLCFPRFFFVSDPALLEILGQASDSHTIQAHLLNVFDNIKSVKFHEKIYDRIL SISSQEGETIELDKPVMAEGNVEVWLNSLLEESQSSLHLVIRQAAANIQETGFQLTEFLSSFPAQVGLLGIQMIWTRDSEEALRNAKFDK KIMQKTNQAFLELLNTLIDVTTRDLSSTERVKYETLITIHVHQRDIFDDLCHMHIKSPMDFEWLKQCRFYFNEDSDKMMIHITDVAFIYQ NEFLGCTDRLVITPLTDRCYITLAQALGMSMGGAPAGPAGTGKTETTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDE FNRIDLPVLSVAAQQISIILTCKKEHKKSFIFTDGDNVTMNPEFGLFLTMNPGYAGRQELPENLKINFRSVAMMVPDRQIIIRVKLASCG FIDNVVLARKFFTLYKLCEEQLSKQVHYDFGLRNILSVLRTLGAAKRANPMDTESTIVMRVLRDMNLSKLIDEDEPLFLSLIEDLFPNIL LDKAGYPELEAAISRQVEEAGLINHPPWKLKVIQLFETQRVRHGMMTLGPSGAGKTTCIHTLMRAMTDCGKPHREMRMNPKAITAPQMFG RLDVATNDWTDGIFSTLWRKTLRAKKGEHIWIILDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPNCKIIFEPHNIDNASPATVSRN GMVFMSSSILDWSPILEGFLKKRSPQEAEILRQLYTESFPDLYRFCIQNLEYKMEVLEAFVITQSINMLQGLIPLKEQGGEVSQAHLGRL FVFALLWSAGAALELDGRRRLELWLRSRPTGTLELPPPAGPGDTAFDYYVAPDGTWTHWNTRTQEYLYPSDTTPEYGSILVPNVDNVRTD FLIQTIAKQGKAVLLIGEQGTAKTVIIKGFMSKYDPECHMIKSLNFSSATTPLMFQRTIESYVDKRMGTTYGPPAGKKMTVFIDDVNMPI INEWGDQVTNEIVRQLMEQNGFYNLEKPGEFTSIVDIQFLAAMIHPGGGRNDIPQRLKRQFSIFNCTLPSEASVDKIFGVIGVGHYCTQR GFSEEVRDSVTKLVPLTRRLWQMTKIKMLPTPAKFHYVFNLRDLSRVWQGMLNTTSEVIKEPNDLLKLWKHECKRVIADRFTVSSDVTWF DKALVSLVEEEFGEEKKLLVDCGIDTYFVDFLRDAPEAAGETSEEADAETPKIYEPIESFSHLKERLNMFLQLYNESIRGAGMDMVFFAD AMVHLVKISRVIRTPQGNALLVGVGGSGKQSLTRLASFIAGYVSFQITLTRSYNTSNLMEDLKVLYRTAGQQGKGITFIFTDNEIKDESF LEYMNNVLSSGEVSNLFARDEIDEINSDLASVMKKEFPRCLPTNENLHDYFMSRVRQNLHIVLCFSPVGEKFRNRALKFPALISGCTIDW FSRWPKDALVAVSEHFLTSYDIDCSLEIKKEVVQCMGSFQDGVAEKCVDYFQRFRRSTHVTPKSYLSFIQGYKFIYGEKHVEVRTLANRM NTGLEKLKEASESVAALSKELEAKEKELQVANDKADMVLKEVTMKAQAAEKVKAEVQKVKDRAQAIVDSISKDKAIAEEKLEAAKPALEE AEAALQTIRPSDIATVRTLGRPPHLIMRIMDCVLLLFQRKVSAVKIDLEKSCTMPSWQESLKLMTAGNFLQNLQQFPKDTINEEVIEFLS PYFEMPDYNIETAKRVCGNVAGLCSWTKAMASFFSINKEVLPLKANLVVQENRHLLAMQDLQKAQAELDDKQAELDVVQAEYEQAMTEKQ TLLEDAERCRHKMQTASTLISGLAGEKERWTEQSQEFAAQTKRLVGDVLLATAFLSYSGPFNQEFRDLLLNDWRKEMKARKIPFGKNLNL SEMLIDAPTISEWNLQGLPNDDLSIQNGIIVTKASRYPLLIDPQTQGKIWIKNKESRNELQITSLNHKYFRNHLEDSLSLGRPLLIEDVG EELDPALDNVLERNFIKTGSTFKVKVGDKEVDVLDGFRLYITTKLPNPAYTPEISARTSIIDFTVTMKGLEDQLLGRVILTEKQELEKER THLMEDVTANKRRMKELEDNLLYRLTSTQGSLVEDESLIVVLSNTKRTAEEVTQKLEISAETEVQINSAREEYRPVATRGSILYFLITEM RLVNEMYQTSLRQFLGLFDLSLARSVKSPITSKRIANIIEHMTYEVYKYAARGLYEEHKFLFTLLLTLKIDIQRNRVKHEEFLTLIKGGA SLDLKACPPKPSKWILDITWLNLVELSKLRQFSDVLDQISRNEKMWKIWFDKENPEEEPLPNAYDKSLDCFRRLLLIRSWCPDRTIAQAR KYIVDSMGEKYAEGVILDLEKTWEESDPRTPLICLLSMGSDPTDSIIALGKRLKIETRYVSMGQGQEVHARKLLQQTMANGGWALLQNCH LGLDFMDELMDIIIETELVHDAFRLWMTTEAHKQFPITLLQMSIKFANDPPQGLRAGLKRTYSGVSQDLLDVSSGSQWKPMLYAVAFLHS TVQERRKFGALGWNIPYEFNQADFNATVQFIQNHLDDMDVKKGVSWTTIRYMIGEIQYGGRVTDDYDKRLLNTFAKVWFSENMFGPDFSF YQGYNIPKCSTVDNYLQYIQSLPAYDSPEVFGLHPNADITYQSKLAKDVLDTILGIQPKDTSGGGDETREAVVARLADDMLEKLPPDYVP FEVKERLQKMGPFQPMNIFLRQEIDRMQRVLSLVRSTLTELKLAIDGTIIMSENLRDALDCMFDARIPAWWKKASWISSTLGFWFTELIE RNSQFTSWVFNGRPHCFWMTGFFNPQGFLTAMRQEITRANKGWALDNMVLCNEVTKWMKDDISAPPTEGVYVYGLYLEGAGWDKRNMKLI -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for FAM105A-DNAH5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FAM105A-DNAH5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FAM105A-DNAH5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C1837618 | CILIARY DYSKINESIA, PRIMARY, 3 | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
| Tgene | C0004096 | Asthma | 1 | CTD_human |
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