|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FAM35A-BMPR1A (FusionGDB2 ID:HG54537TG657) |
Fusion Gene Summary for FAM35A-BMPR1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAM35A-BMPR1A | Fusion gene ID: hg54537tg657 | Hgene | Tgene | Gene symbol | FAM35A | BMPR1A | Gene ID | 54537 | 657 |
| Gene name | shieldin complex subunit 2 | bone morphogenetic protein receptor type 1A | |
| Synonyms | FAM35A|FAM35A1|RINN2|bA163M19.1 | 10q23del|ACVRLK3|ALK3|CD292|SKR5 | |
| Cytomap | ('FAM35A')('BMPR1A') 10q23.2 | 10q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | shieldin complex subunit 2RINN1-REV7-interacting novel NHEJ regulator 2family with sequence similarity 35 member Aprotein FAM35Ashield complex subunit 2 | bone morphogenetic protein receptor type-1AALK-3BMP type-1A receptorBMPR-1Aactivin A receptor, type II-like kinase 3activin receptor-like kinase 3bone morphogenetic protein receptor, type IAserine/threonine-protein kinase receptor R5 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000298784, ENST00000298786, | ENST00000298784, ENST00000298786, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 4 X 4 X 2=32 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FAM35A [Title/Abstract] AND BMPR1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FAM35A(88912636)-BMPR1A(88649819), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | FAM35A-BMPR1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FAM35A-BMPR1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FAM35A-BMPR1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FAM35A-BMPR1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FAM35A | GO:0045830 | positive regulation of isotype switching | 29656893 |
| Hgene | FAM35A | GO:2000042 | negative regulation of double-strand break repair via homologous recombination | 29656893 |
| Hgene | FAM35A | GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining | 29656893|29789392 |
| Tgene | BMPR1A | GO:0006468 | protein phosphorylation | 12065756 |
| Tgene | BMPR1A | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 9389648|24904118 |
| Tgene | BMPR1A | GO:0030509 | BMP signaling pathway | 9389648|18436533 |
| Tgene | BMPR1A | GO:0060391 | positive regulation of SMAD protein signal transduction | 9389648 |
| Fusion gene breakpoints across FAM35A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across BMPR1A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A8-A09N-01A | FAM35A | chr10 | 88912636 | + | BMPR1A | chr10 | 88649819 | + |
Top |
Fusion Gene ORF analysis for FAM35A-BMPR1A |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000298784 | ENST00000480152 | FAM35A | chr10 | 88912636 | + | BMPR1A | chr10 | 88649819 | + |
| 5CDS-3UTR | ENST00000298786 | ENST00000480152 | FAM35A | chr10 | 88912636 | + | BMPR1A | chr10 | 88649819 | + |
| In-frame | ENST00000298784 | ENST00000372037 | FAM35A | chr10 | 88912636 | + | BMPR1A | chr10 | 88649819 | + |
| In-frame | ENST00000298786 | ENST00000372037 | FAM35A | chr10 | 88912636 | + | BMPR1A | chr10 | 88649819 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000298784 | FAM35A | chr10 | 88912636 | + | ENST00000372037 | BMPR1A | chr10 | 88649819 | + | 12290 | 1639 | 114 | 3170 | 1018 |
| ENST00000298786 | FAM35A | chr10 | 88912636 | + | ENST00000372037 | BMPR1A | chr10 | 88649819 | + | 12290 | 1639 | 114 | 3170 | 1018 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000298784 | ENST00000372037 | FAM35A | chr10 | 88912636 | + | BMPR1A | chr10 | 88649819 | + | 5.79E-05 | 0.99994206 |
| ENST00000298786 | ENST00000372037 | FAM35A | chr10 | 88912636 | + | BMPR1A | chr10 | 88649819 | + | 5.79E-05 | 0.99994206 |
Top |
Fusion Genomic Features for FAM35A-BMPR1A |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| FAM35A | chr10 | 88912636 | + | BMPR1A | chr10 | 88649818 | + | 8.37E-07 | 0.99999917 |
| FAM35A | chr10 | 88912636 | + | BMPR1A | chr10 | 88649818 | + | 8.37E-07 | 0.99999917 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for FAM35A-BMPR1A |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:88912636/chr10:88649819) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | BMPR1A | chr10:88912636 | chr10:88649819 | ENST00000372037 | 2 | 13 | 204_233 | 22 | 533.0 | Domain | GS | |
| Tgene | BMPR1A | chr10:88912636 | chr10:88649819 | ENST00000372037 | 2 | 13 | 234_525 | 22 | 533.0 | Domain | Protein kinase | |
| Tgene | BMPR1A | chr10:88912636 | chr10:88649819 | ENST00000372037 | 2 | 13 | 240_248 | 22 | 533.0 | Nucleotide binding | ATP | |
| Tgene | BMPR1A | chr10:88912636 | chr10:88649819 | ENST00000372037 | 2 | 13 | 177_532 | 22 | 533.0 | Topological domain | Cytoplasmic | |
| Tgene | BMPR1A | chr10:88912636 | chr10:88649819 | ENST00000372037 | 2 | 13 | 24_152 | 22 | 533.0 | Topological domain | Extracellular | |
| Tgene | BMPR1A | chr10:88912636 | chr10:88649819 | ENST00000372037 | 2 | 13 | 153_176 | 22 | 533.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for FAM35A-BMPR1A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >29013_29013_1_FAM35A-BMPR1A_FAM35A_chr10_88912636_ENST00000298784_BMPR1A_chr10_88649819_ENST00000372037_length(transcript)=12290nt_BP=1639nt ACGGGCGGCCGGATTTGCCCGGAGGCCGCACCCGCCTCCGGCGGGGCTCTCAGTGAAAAATGTACTCTGACCTGAATCCTGAATTTTCCT TGATGGTCAAAAGATTAAGAAATCATGAGTGGAGGATCTCAAGTCCACATTTTTTGGGGTGCTCCAATTGCTCCACTGAAAATCACAGTA TCAGAAGACACAGCTTCTTTAATGTCTGTTGCTGACCCCTGGAAAAAAATTCAGCTTTTATACAGTCAACATTCTTTATATCTGAAGGAT GAAAAACAGCACAAAAATCTTGAAAACTATAAAGTCCCAGAATCTATTGGTTCTCCAGATCTTAGTGGTCATTTCTTAGCAAACTGTATG AATAGACATGTTCATGTGAAAGATGACTTTGTACGTTCTGTTTCTGAAACACAGAATATAGAATCCCAGAAGATTCACTCCTCTAGACTG AGTGATATAACTAGCTCTAATATGCAAATATGTGGATTTAAAAGCACAGTTCCGCATTTCACCGAAGAAGAAAAGTATCAAAAGCTTCTC AGTGAAAATAAAATTAGAGATGAACAGCCTAAACATCAGCCAGATATATGTGGTAAGAACTTTAACACAAATTTGTTTCAGTTGGGCCAT AAATGTGCAGCTGTGTTGGATTTGGTTTGTAGTACTGAAAAAATTAATATAGGGCCTGAAGTGGTACAAAGAGAGTGTGTGCCAACAGAA TATCATGAAATACAAAACCAGTGTTTGGGATTATTTTCCTCGAACGCAGTAGATAAGTCAAGGTCTGAAGCAGCAGTTAGGAAGGTCTCA GACCTTAAAATATCAACTGATACAGAATTTCTCAGTATAATTACCTCCAGCCAGGTTGCTTTTTTAGCTCAAAAGAAAGATAAAAGGCGG AGTCCTGTAAATAAAGGGAATGTAAACATGGAGACTGAACCAAAGGCAAGTTACGGGGAGATAAGAATACCTGAAGAGAATTCGATTCAG CTTGATGGTTTTACAGAAGCATATGAAAGTGGACAAAACCAAGCATATTCCCTTGAACTTTTTAGTCCTGTTTGTCCTAAAACAGAAAAT AGCCGCATTCACATAAACTCTGATAAAGGTCTTGAAGAACATACAGGATCTCAAGAACTTTTCAGTTCTGAAGATGAACTGCCACCAAAT GAGATACGTATTGAGTTGTGTAGCTCAGGAATACTGTGTTCCCAACTAAATACCTTCCACAAAAGTGCTATTAAAAGAAGCTGTACCTCT GAAGATAAAGTGGGCCAGTCTGAAGCTCTATCTAGAGTCCTTCAAGTAGCTAAGAAAATGAAGTTGATTTCTAATGGAGGAGATTCTGCT GTAGAAATGGATCGGAGAAATGTGTCTGAATTTAAGAGTATTAAAAAAACATCATTAATAAAAAACTGTGATTCTAAAAGCCAGAAGTAT AATTGTTTAGTCATGGTGCTATCTCCATGCCATGTGAAGGAAATAAACATAAAATTCGGACCAAATTCTGGCTCTAAAGTGCCTTTAGCA ACAGTTACAGTAATTGATCAATCAGAAACTAAGAAGAAGGTTTTTCTGTGGAGGACTGCAGCATTTTGGGCATTTACAGTGTTTCTTGGA GATATAATTTTACTCACAGGACAGAATCTGGATAGTATGCTTCATGGCACTGGGATGAAATCAGACTCCGACCAGAAAAAGTCAGAAAAT GGAGTAACCTTAGCACCAGAGGATACCTTGCCTTTTTTAAAGTGCTATTGCTCAGGGCACTGTCCAGATGATGCTATTAATAACACATGC ATAACTAATGGACATTGCTTTGCCATCATAGAAGAAGATGACCAGGGAGAAACCACATTAGCTTCAGGGTGTATGAAATATGAAGGATCT GATTTTCAGTGCAAAGATTCTCCAAAAGCCCAGCTACGCCGGACAATAGAATGTTGTCGGACCAATTTATGTAACCAGTATTTGCAACCC ACACTGCCCCCTGTTGTCATAGGTCCGTTTTTTGATGGCAGCATTCGATGGCTGGTTTTGCTCATTTCTATGGCTGTCTGCATAATTGCT ATGATCATCTTCTCCAGCTGCTTTTGTTACAAACATTATTGCAAGAGCATCTCAAGCAGACGTCGTTACAATCGTGATTTGGAACAGGAT GAAGCATTTATTCCAGTTGGAGAATCACTAAAAGACCTTATTGACCAGTCACAAAGTTCTGGTAGTGGGTCTGGACTACCTTTATTGGTT CAGCGAACTATTGCCAAACAGATTCAGATGGTCCGGCAAGTTGGTAAAGGCCGATATGGAGAAGTATGGATGGGCAAATGGCGTGGCGAA AAAGTGGCGGTGAAAGTATTCTTTACCACTGAAGAAGCCAGCTGGTTTCGAGAAACAGAAATCTACCAAACTGTGCTAATGCGCCATGAA AACATACTTGGTTTCATAGCGGCAGACATTAAAGGTACAGGTTCCTGGACTCAGCTCTATTTGATTACTGATTACCATGAAAATGGATCT CTCTATGACTTCCTGAAATGTGCTACACTGGACACCAGAGCCCTGCTTAAATTGGCTTATTCAGCTGCCTGTGGTCTGTGCCACCTGCAC ACAGAAATTTATGGCACCCAAGGAAAGCCCGCAATTGCTCATCGAGACCTAAAGAGCAAAAACATCCTCATCAAGAAAAATGGGAGTTGC TGCATTGCTGACCTGGGCCTTGCTGTTAAATTCAACAGTGACACAAATGAAGTTGATGTGCCCTTGAATACCAGGGTGGGCACCAAACGC TACATGGCTCCCGAAGTGCTGGACGAAAGCCTGAACAAAAACCACTTCCAGCCCTACATCATGGCTGACATCTACAGCTTCGGCCTAATC ATTTGGGAGATGGCTCGTCGTTGTATCACAGGAGGGATCGTGGAAGAATACCAATTGCCATATTACAACATGGTACCGAGTGATCCGTCA TACGAAGATATGCGTGAGGTTGTGTGTGTCAAACGTTTGCGGCCAATTGTGTCTAATCGGTGGAACAGTGATGAATGTCTACGAGCAGTT TTGAAGCTAATGTCAGAATGCTGGGCCCACAATCCAGCCTCCAGACTCACAGCATTGAGAATTAAGAAGACGCTTGCCAAGATGGTTGAA TCCCAAGATGTAAAAATCTGATGGTTAAACCATCGGAGGAGAAACTCTAGACTGCAAGAACTGTTTTTACCCATGGCATGGGTGGAATTA GAGTGGAATAAGGATGTTAACTTGGTTCTCAGACTCTTTCTTCACTACGTGTTCACAGGCTGCTAATATTAAACCTTTCAGTACTCTTAT TAGGATACAAGCTGGGAACTTCTAAACACTTCATTCTTTATATATGGACAGCTTTATTTTAAATGTGGTTTTTGATGCCTTTTTTTAAGT GGGTTTTTATGAACTGCATCAAGACTTCAATCCTGATTAGTGTCTCCAGTCAAGCTCTGGGTACTGAATTGCCTGTTCATAAAACGGTGC TTTCTGTGAAAGCCTTAAGAAGATAAATGAGCGCAGCAGAGATGGAGAAATAGACTTTGCCTTTTACCTGAGACTTTCAGTTCGTTTGTA TTCTACCTTTGTAAAACAGCCTATAGATGATGATGTGTTTGGGATACTGCTTATTTTATGATAGTTTGTCCTGTGTCCTTAGTGATGTGT GTGTGTCTCCATGCACATGCACGCCGGGATTCCTCTGCTGCCATTTGAATTAGAAGAAAATAATTTATATGCATGCACAGGAAGATATTG GTGGCCGGTGGTTTTGTGCTTTAAAAATGCAATATCTGACCAAGATTCGCCAATCTCATACAAGCCATTTACTTTGCAAGTGAGATAGCT TCCCCACCAGCTTTATTTTTTAACATGAAAGCTGATGCCAAGGCCAAAAGAAGTTTAAAGCATCTGTAAATTTGGACTGTTTTCCTTCAA CCACCATTTTTTTTGTGGTTATTATTTTTGTCACGGAAAGCATCCTCTCCAAAGTTGGAGCTTCTATTGCCATGAACCATGCTTACAAAG AAAGCACTTCTTATTGAAGTGAATTCCTGCATTTGATAGCAATGTAAGTGCCTATAACCATGTTCTATATTCTTTATTCTCAGTAACTTT TAAAAGGGAAGTTATTTATATTTTGTGTATAATGTGCTTTATTTGCAAATCACCCACTCCTTTACAACCATACTTTATATATGTACATAC ATTCATACTGTAGAAACCAGCTCATGTGTACCTCATATCCCATCCTTAAGAGAAGAAATGTTATAAAGTAGAACTAAATATAAATTTTCA GAATTAATGCATTCAAAGTAATATATCAAATCCAGGACTTTGTTAACTTCAGGTAAAAACTTCATTAGGGTAATATCATCTCAATTTTTT CAAATGAAAGGATTCTCTAATTAGAAATTTATATGTCAGAGCTGTTATAAATTTATCAACTGTCAAATATGTTCTGGACAGCTAAATCAT TTGAGATTTTTGGTTTTTTGATTTCTATTCCCTAACTTGTGAAGACAATGAAAAATCAGGCAGAAATATTTAGTATCTAGTCAGTATCTG TAGCTACACTGTATAACTGTTCTTCAATAAAATGGTTCATATTTTATAGATGCCTTGTTATCTCAAGAAATCTGATTTACATAAACTTAT ACTTCTTTAATGCTTTTTAAATATTTATTCTGAGCAAACAATTCATGAGTACATCAAGTGAGATAGTTTTATTTGATTATAACATAAAAT AAATGTGATTATATCACATCATCATCAAAAAGGTTTAAATTAAATGGGAGGAAATCAGCATATGTCCACCCATTACCAAAATTTGACTAT CATTTAAGGTTAAAACTTACAAATTTGTCTGCACATCAAATTTCACAAATTTGAAAATTGCCTTAACCATTTTGATTAATAAGTTTCATC TGCCATAATTAAAGTCTGAAGTGTTCATCAAGATAAGTAAATTTGCATATGGATAATACCCAATAACTTGTTTTTTCAGAATTTTTCACC ATATGTATACTGAGAAATACAAATATTTTAATCTGCGTTGCCGTATGATATGATTGCACTTAGAACACCCAATTTACTTAAATCTTGGTT TACTTTTGACTTGATACCATAATCTTTAAAATCATTTGTCATCTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCT GGACTGCGGACTGCAGTGGCGCAATCTCGGCTCACTGCAAGCTCCGCTTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAG CTGGGACTACAGGCGCCCGCCACCGCGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTAGCCAGGATGGTCTC AATCTCCTGACCTCATGATCCACCTGCCTCGGCCTCCCAAAGTTCATTTGTCATCTTAATAAAAATATAAAGACAGGCAAAGTTTATTGG AAATGTTCAAATGGTGTGTGGAAGCAAAAAATTACAGCCAGTATATGAGACCACTATTATGGTTTTTTAAAATTAACTTGGTCTAGTAAA AGTGATATCAAGAGTTAATCTTAGAAACTTGCTCAGTAAAAACATTTTCTAGTATAACATGTTCTTTAAAAAGCAAATGCTGCCGTCTTT GGAATCTTAATCTAAAAATGTGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCGGGTGGATCACAAGGT CAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAAAAAACTCAGCCAGGCGTGGTGGCGGGTGCCTGT AATCCCAGCTACTCGGGAGGCTGAAGCAGGAGAATTGCTTAAAATCAGAAGGTGGAGGTTGCAGTGAGCTGAGATCGTGTCACTGCACTC CAGCCTGGGCAAAAGAGCGAAACTCCATCTCAAATAAACAAACAAATAAATAACAAAAAACAAAAATGTTGCATTAAACTTAGTTCTTGT CTCTCCTTTCCACTCTTATTCTTAAATCTGAAGCTCATCGACTAAGTGAAATATTTAAAGAATATGATAGGCCAGCAAGAAGAAGTATTA TGTAGTACCATAGTTAGTAAATTCGTAAAACCTTGGAAGCCATTATTTGGTCCCACTTGCAATTTAGTGTTTTTGAAGTGTGTAGCTTCA TTCAGATAGCTCTTTAAATAATTAAAATATAAAAGCAAACAACCCAAACTACCTGACTATAAACAGGAAAAGTTAACCCTCAAAGAGAGT TCTTGTGAATTCTCTTTATGCTGGCAAATAGCTCTAGGATTAAAGGCACATTAGGGTTTCCTTCAGTTTGTTTATTCTAAGCTTTTACTG TGCTTTTTACTGAACAAGTTTCTGATGTATAAAACTTGCATCTGATTTCTTTGGAAATATTTTCACAAAAGTTATTTTAATCAGTATTTT TACATTGCCTTTCCAGTGTCCAGAAGTGTTTCTAAACTTAGAAAGTGACCTATAGTTTTTTAAAATTATGTTTTCCTAGAACGTGCCAAA TTTTGATTTACTCTAACAATCAGTACTTTTCTTCAGATGCTTTGTTCTGTTTAGAACAAAAATGCACTATAGTTTTTAAAGAATCATGCA TCTTTGGGTTGGCCCAGGATCAAATTTGATATTGAATAATTTATTCCAGGGCAGCTTTCATAAACATACTTCATAGATGTTGTTTTGAAA TGTTTCTAAATATCTAAAATCATTTCAACAGCAGAAATGATTTTTATTTTAACAAAAGATTATGATAGCCCTTGTAGTGTTTAAAAGTGG TCATATTTATTACTGACTTTGAGTCAGGTGTTAAAATAGCAGTGCCACAGCTCGTCTCTTGCCTTAGTGTGCTGCTGTGAGAGTCACAGT GGAAACTGCAGGGAGGAGGTGTGTTCCTAAGAACCAAAATCCAGCACAGCATCCTGTGAAGCCACGTGTAATGATGGTCCCATAAGGAAA GTATGTGAATATGGCTCTTGTAAAGGATTAACTATTGTAATTTTAGCTTATGCTCTGTATTCTGTTTTCTATGGAATTATTTAAGCCCTT TTAGTGACCTTTGTCCTGGCCCATTTAAAAACTAAAATGTAGTATATATTGTATAAAATGGAAATATCATTATTGCTTCATTAGGGGAAA CTGTACATAGGCATTGAAAGAAGGGTAAAAGCAAGCAGTTTTATCAGGCAGTTGTAAAACACCAAAAATATAGATTCGTCTTTGACGTGT AACACACTAAATGTATTTTGTACAGCATCTGGTTTAAAAGGTGCCTTAAGAGTTTACCATTACTTGCTTTGTTCTATATACAGATTATGT CCAATGTATCATTTTGAAGTAAATAACCTTATTTTAGTATACTTTAGTGATGTGTTTTGTGATGCTACACTCAGACGGTATTGTGCATCA GAAGTCATCTGTTGAGATTTTTGTAATGATTAAGTTAGTGTATATACATATGTTCCTGAGATGTACACTTCAACTACCAGAAACCCAGTA TGGAGCACAGGTAGGTACACGCTTGCCCTGTGGAGATAGAGAACTTCTAAACCTATCACGGTGCAGGGGTTTTTCCTTTAAAAAACAAGA CAAAACATTGTTTTCTTTTTCCTTTTTTTTTTTTTTTTTTTGAGACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCACGAT CTCAGCTCACTGCAACCTTTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAATAGCTGGAACTACAGGTGTTTGCCACCA TGCCTGGCTAATTTTTTGTATTTTTAATAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGGCCCAC TTGCCTTGGCCTCCCAAAGTGCTGAGCTTACAGGCATGAGCCACCATGCCTGGCCAAAACATTGTTTTCTGATTATGGAAATGTACTCAT GGCAGAAAATTTGGGAAACAACAGCAAATAATAAAGCAAATAAAAATCACTCAAAATTCTATTGCCAGACATTATCACTATATACATTTG AGTGTTTCTTTTCAATCTTTTTTTTTGAGAGAGTCTTGCTCTGTCACTCAGGGTGGAGTGCAGTAGCGCGATCTCGGCTCAGTGCAACCT CTGCCCCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCCGGGATTACAGGTGTGCACCACCACGCCCGGCTAATTTTTGT ATTTTAGTAGAGATGCGGTTTCACCATGTTGGCCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCTGCCTACCTCAGCCTCCCAAAG TGCTGGGATTACAGGAGTGAGCCACTGCACCCGGCCTTATTCTTTTTTATGTTGCATTTTTTGTAATATTAGGATCCTAGTATGCCATTA AATAGCCATTGAGAACTTTTTTTTTAATGACTGCACAATATTTGACTAAGAAGATGGAGTAATTTCTGTGCTCAATCCCCTATTGAATAT TTGGATTATTTTCATTGTTTTGAAAAATAGATATTAAGCATCCTTATACATAAATCTTTATTTTCTTATATTACATTTCTGAAAATGAGA CTAGTGGATATGAACTTTTAAAAGATCCTTTAAGATGGAAAAACTAAGGTTCTTGGAAAACATTGCCATATTGCTACTCACAAAGCTTTT CATTTTCATTCCTGCTAGCAGTTCATGAGCTTAGAGCGATGGGATGCATTTACCTGGCCTTAAGATGCTCCTGCTGCAATGGGAAGTGAA GCCTTGGATAGCTTTCCTCCTCCTGTGCAATACTTTCTTGTCATTTTCCCACCTGCACTGAGTCCCACCGCCAGTCAGGGCTGTTTTCAG GTGTATGTGAATTCATCCCAGCAGTGTGCCTTCTGCTGCCTTTTCCTAGGGAACTGAACATGTTAAATCACAGACGCGATGTGGCACTGA TTATTGTTCCTCAAAAGAAATGCGTGTCTGAAGATAGCCTCTTACAGATTCCTCACGGGAGTCTCTGTTCAGTGTCATTGTAAGTTTCTC AGAATAATCGCAGGCGCTCTGATGCAGCCTGGTAAAGAAGACTCAGTGATTTCTGGGAACTGCAAATGCTTGCCAGCTTTCCTTCTGTCT GTGGAAACACTGAATAAATGTATTCATTTCTCCTTTCCAGCAATCTGTTAGTCTCACTGCTCCATTCCAAGGTTTCTTTAATATTATTAA CAGAGCAGACATTAAGAAACAGAATTGTCTAATCCTTGTTCTTCCAAAATAGGTTTAATCCTTGTAGATAGTTTCAAGCAGACAGTAAGT CAGTTACTAAGTTTTCACTTGGAGAAACATTTGCTGATAGTAGTAGCATATTGACCATTTCTGACATGTCATCCTTATATCAAGTTAGGT GCACGCTCCTACACAGCCTTGGCTCAGCGCTTGGAGCATACAGTCTTGACTGGGTGGACATAAACCGCTGAAAGTGGCCAGCAGTGAGCA GAGGCCACCTACTATCAGCGGCACTGCTGCAGGCATGGAGACTTAAATGTGTGAGTGCTGGTATAAGCAGAAGTGGGAGAGTCACCTCGA TGCTGGGATCCAGATGGCGGCTTATTTCAAGTGCAGTGGCACATACAAAAAATATTTTTGGAAGGGAGCAAGGACTAGGGCTGAAAGGTT CATTCATAATCTTTTTTTCTTTTTTTTTTTAGGTGGAGTCTCGCTCTGTCACCCAGGCTGGAGCGCAATGGGGTGATCCCAGCTCACTGC AACCTCCACCTCCCGGGTTAAAGCAATTCTCCTGCCTCAGCCACCTGAGAAGTTGGGATTACAGGCGTGCACCACCACACTCAGCTAATT TTGTATTTTTAGTAGAGACGGGGTTTACCATGTGGGCCAGGCTGGTCTCGAACTCCCAACCTCAGGTGATCTGCCCACCTTGGCCTTCCA GAGTGCTGGGATTATAGGCGTGAGCCACTGCGCCCAGCCCATAATCTCCTTTTGACATAGGAATTGTTAATTCACATATTCCATCAACCT ATTGCTCCTCTGAATCTTAGCAGCTTCTTGGTCTTTGTTCAAATGAAATCTAAGTCAATTCCATATCTCTCAATGTCGCTACATCCACCT CAGTGCTTATATCCTAATTTTGTCTTTTTTAGAGACAGTCTTGCACTGTCACCCAGGCTAGTGTGCAGTGGCTGTTCACAGGCATAATCA TAACGCACTGTAGCCTCAAACTCCTGATCTCAAGCCATCCTCCCACCTCAGCCTCCTGAGTAGCTGGGACCATGCCACCATGCCTGGCTC ACATTCTAAACATTATGCAGGAAGCTCAAAGTGAAAATCAATATGGAATGTTTATATTGAAAATATTTTTGGCTGGGTGCAGTGGCTAAT GCCTCTAATCCCAGCACTCTGGGAGGCTGAGGCGGGCAGACCACCTGAGGTCAGGAGCAGCCTGGCCAACATATAGTGAAACCCTGTCTC TAAGGTACAAAAATTAGCTGGGTGTGGTGGTACTCGCCTGTAGTCCCAGCTCCTTGGGAAGCTGAGGCAGGAGAATCACTTGAACCCAGG AGGCGGAGGTTGCAGTGAGCTGAGATCGCACCACTGCATTCCAGGCTGGGCAACAGAGCAAGACTCCGTCTCTCAAAAAAAAAAAAAGAA AAAAAAATATATATATATATATACACACACACACACACACATATATATATATATATTCAAGCAATGTGAAGAAAATATTGGGCCCCCTTG TTTTTCTTTAATGGAAGAGCCATTTTTAAAAGCCAGTTTAGAATCCAGATGATGACATCTGTTGCTCTACTGTATGACTGAAATGCAGGT CAGTGTTGAAAAACATAAAAAATTGGAAGTCTCCACTGAAAGACCTACACTGCTGTGGGAGGGATTTTAATCAAGACATTTCAAAAGCAA TTTTTATTACTTGATCCTGTCCTCATACTTGGCTAGGAGTTCAGCTGGAGATAGAATCTAACTCTGAAGATGATACTCCATGATCTTCTA GCATCCCTTGTCACCAGTGAGAAGTCTGATGTGGATCTAATAAGTGACATGTTATACAGGTTAACTTATTTTCAAGAAATAGAATTTTCT TTTTATTATTGATGTTGGAAGTTGAAACTGGCCATATCTAAATATATTCATTCTGTTTCTTAGTACTAATGGGATCTTTTCTTAGACCTG GGAAATTTTCTCCCATTATTTCTTTTGTTTCTTCCCTTTTTTCTTTCTTTTCCTTTTCTCTTTCTAGAACTTTCTAGAACAAATCTCAGG TCCCCTAGATGTTTCTTCCATAATTGTTACTATGCTTCTCATATGTTTCATCCTACCTTCTACTTTTGTCAGCCCATCTGAGTTTATTTC AACAGCCAAATGTTTTATTTTGAAATGATTCCAGGCTTCCATTAAAGTTTCATCAATAGTATAAGGACTGCCATTTACCCTTCACCCAGA TTCATAAACTGCTAACATTGCACAATTGCTTTGTCATTCTGTGTGTGTGTGTACAGGAATCACAGAGACTCATCTTGTAATGTTTGTAAT GTCCATGTATCGTGTATGCACACATTTTTTTCTGACCTATTAGAAGCAAATTACAGAGCTAATACCCCTTTATCCCTAAATACTTCAGGG ATGTTCTATTACTTAACCAATTATGTACAATTATCAGAACCAGGAAAGTTCACATTGATACAATAGCAATGACCAACAATACCATAATCT ATAGACCTTACTGAAGTTTTGCTAATTGTTATTTTGGTGTGGTTGGGTTTTTTGTTTGTTTGAGATAGGGTCTCACTCTGTCACCCAGGC TGGAGTACAGTGGCACAGTCATAGCTCACTTCAACCTCAAACTTTGGGCCTCAAGCGATCCTCCCGCCTCAGCCTCCCAAAGGGCTATGA TTACAGGCATGAGCCACCATGCTGGCCTCATTTCCCCTTTCCTTCTCAAAAGGATTCTGGCTTTCCCTACTGCATTCATCCACGTCCACT ACCCGCTCCAAGAGAGCTGAGTAATTGTCAAGCCAGGTTTGGGGAGCTTTCTTGATGGAGGGGATGGAAGGAGGGTGGTGCTCAGGCTAC AGCAGGGAGAGCTTTTCTGTTTTTGAGCTAAAGACATAACAGGGTGCAGAGGCTGAGAAAAGGAGAGTTCTAAGCAACATGTCACGAGCT >29013_29013_1_FAM35A-BMPR1A_FAM35A_chr10_88912636_ENST00000298784_BMPR1A_chr10_88649819_ENST00000372037_length(amino acids)=1018AA_BP=508 MSGGSQVHIFWGAPIAPLKITVSEDTASLMSVADPWKKIQLLYSQHSLYLKDEKQHKNLENYKVPESIGSPDLSGHFLANCMNRHVHVKD DFVRSVSETQNIESQKIHSSRLSDITSSNMQICGFKSTVPHFTEEEKYQKLLSENKIRDEQPKHQPDICGKNFNTNLFQLGHKCAAVLDL VCSTEKINIGPEVVQRECVPTEYHEIQNQCLGLFSSNAVDKSRSEAAVRKVSDLKISTDTEFLSIITSSQVAFLAQKKDKRRSPVNKGNV NMETEPKASYGEIRIPEENSIQLDGFTEAYESGQNQAYSLELFSPVCPKTENSRIHINSDKGLEEHTGSQELFSSEDELPPNEIRIELCS SGILCSQLNTFHKSAIKRSCTSEDKVGQSEALSRVLQVAKKMKLISNGGDSAVEMDRRNVSEFKSIKKTSLIKNCDSKSQKYNCLVMVLS PCHVKEINIKFGPNSGSKVPLATVTVIDQSETKKKVFLWRTAAFWAFTVFLGDIILLTGQNLDSMLHGTGMKSDSDQKKSENGVTLAPED TLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIG PFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQI QMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCA TLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLD ESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECW -------------------------------------------------------------- >29013_29013_2_FAM35A-BMPR1A_FAM35A_chr10_88912636_ENST00000298786_BMPR1A_chr10_88649819_ENST00000372037_length(transcript)=12290nt_BP=1639nt ACGGGCGGCCGGATTTGCCCGGAGGCCGCACCCGCCTCCGGCGGGGCTCTCAGTGAAAAATGTACTCTGACCTGAATCCTGAATTTTCCT TGATGGTCAAAAGATTAAGAAATCATGAGTGGAGGATCTCAAGTCCACATTTTTTGGGGTGCTCCAATTGCTCCACTGAAAATCACAGTA TCAGAAGACACAGCTTCTTTAATGTCTGTTGCTGACCCCTGGAAAAAAATTCAGCTTTTATACAGTCAACATTCTTTATATCTGAAGGAT GAAAAACAGCACAAAAATCTTGAAAACTATAAAGTCCCAGAATCTATTGGTTCTCCAGATCTTAGTGGTCATTTCTTAGCAAACTGTATG AATAGACATGTTCATGTGAAAGATGACTTTGTACGTTCTGTTTCTGAAACACAGAATATAGAATCCCAGAAGATTCACTCCTCTAGACTG AGTGATATAACTAGCTCTAATATGCAAATATGTGGATTTAAAAGCACAGTTCCGCATTTCACCGAAGAAGAAAAGTATCAAAAGCTTCTC AGTGAAAATAAAATTAGAGATGAACAGCCTAAACATCAGCCAGATATATGTGGTAAGAACTTTAACACAAATTTGTTTCAGTTGGGCCAT AAATGTGCAGCTGTGTTGGATTTGGTTTGTAGTACTGAAAAAATTAATATAGGGCCTGAAGTGGTACAAAGAGAGTGTGTGCCAACAGAA TATCATGAAATACAAAACCAGTGTTTGGGATTATTTTCCTCGAACGCAGTAGATAAGTCAAGGTCTGAAGCAGCAGTTAGGAAGGTCTCA GACCTTAAAATATCAACTGATACAGAATTTCTCAGTATAATTACCTCCAGCCAGGTTGCTTTTTTAGCTCAAAAGAAAGATAAAAGGCGG AGTCCTGTAAATAAAGGGAATGTAAACATGGAGACTGAACCAAAGGCAAGTTACGGGGAGATAAGAATACCTGAAGAGAATTCGATTCAG CTTGATGGTTTTACAGAAGCATATGAAAGTGGACAAAACCAAGCATATTCCCTTGAACTTTTTAGTCCTGTTTGTCCTAAAACAGAAAAT AGCCGCATTCACATAAACTCTGATAAAGGTCTTGAAGAACATACAGGATCTCAAGAACTTTTCAGTTCTGAAGATGAACTGCCACCAAAT GAGATACGTATTGAGTTGTGTAGCTCAGGAATACTGTGTTCCCAACTAAATACCTTCCACAAAAGTGCTATTAAAAGAAGCTGTACCTCT GAAGATAAAGTGGGCCAGTCTGAAGCTCTATCTAGAGTCCTTCAAGTAGCTAAGAAAATGAAGTTGATTTCTAATGGAGGAGATTCTGCT GTAGAAATGGATCGGAGAAATGTGTCTGAATTTAAGAGTATTAAAAAAACATCATTAATAAAAAACTGTGATTCTAAAAGCCAGAAGTAT AATTGTTTAGTCATGGTGCTATCTCCATGCCATGTGAAGGAAATAAACATAAAATTCGGACCAAATTCTGGCTCTAAAGTGCCTTTAGCA ACAGTTACAGTAATTGATCAATCAGAAACTAAGAAGAAGGTTTTTCTGTGGAGGACTGCAGCATTTTGGGCATTTACAGTGTTTCTTGGA GATATAATTTTACTCACAGGACAGAATCTGGATAGTATGCTTCATGGCACTGGGATGAAATCAGACTCCGACCAGAAAAAGTCAGAAAAT GGAGTAACCTTAGCACCAGAGGATACCTTGCCTTTTTTAAAGTGCTATTGCTCAGGGCACTGTCCAGATGATGCTATTAATAACACATGC ATAACTAATGGACATTGCTTTGCCATCATAGAAGAAGATGACCAGGGAGAAACCACATTAGCTTCAGGGTGTATGAAATATGAAGGATCT GATTTTCAGTGCAAAGATTCTCCAAAAGCCCAGCTACGCCGGACAATAGAATGTTGTCGGACCAATTTATGTAACCAGTATTTGCAACCC ACACTGCCCCCTGTTGTCATAGGTCCGTTTTTTGATGGCAGCATTCGATGGCTGGTTTTGCTCATTTCTATGGCTGTCTGCATAATTGCT ATGATCATCTTCTCCAGCTGCTTTTGTTACAAACATTATTGCAAGAGCATCTCAAGCAGACGTCGTTACAATCGTGATTTGGAACAGGAT GAAGCATTTATTCCAGTTGGAGAATCACTAAAAGACCTTATTGACCAGTCACAAAGTTCTGGTAGTGGGTCTGGACTACCTTTATTGGTT CAGCGAACTATTGCCAAACAGATTCAGATGGTCCGGCAAGTTGGTAAAGGCCGATATGGAGAAGTATGGATGGGCAAATGGCGTGGCGAA AAAGTGGCGGTGAAAGTATTCTTTACCACTGAAGAAGCCAGCTGGTTTCGAGAAACAGAAATCTACCAAACTGTGCTAATGCGCCATGAA AACATACTTGGTTTCATAGCGGCAGACATTAAAGGTACAGGTTCCTGGACTCAGCTCTATTTGATTACTGATTACCATGAAAATGGATCT CTCTATGACTTCCTGAAATGTGCTACACTGGACACCAGAGCCCTGCTTAAATTGGCTTATTCAGCTGCCTGTGGTCTGTGCCACCTGCAC ACAGAAATTTATGGCACCCAAGGAAAGCCCGCAATTGCTCATCGAGACCTAAAGAGCAAAAACATCCTCATCAAGAAAAATGGGAGTTGC TGCATTGCTGACCTGGGCCTTGCTGTTAAATTCAACAGTGACACAAATGAAGTTGATGTGCCCTTGAATACCAGGGTGGGCACCAAACGC TACATGGCTCCCGAAGTGCTGGACGAAAGCCTGAACAAAAACCACTTCCAGCCCTACATCATGGCTGACATCTACAGCTTCGGCCTAATC ATTTGGGAGATGGCTCGTCGTTGTATCACAGGAGGGATCGTGGAAGAATACCAATTGCCATATTACAACATGGTACCGAGTGATCCGTCA TACGAAGATATGCGTGAGGTTGTGTGTGTCAAACGTTTGCGGCCAATTGTGTCTAATCGGTGGAACAGTGATGAATGTCTACGAGCAGTT TTGAAGCTAATGTCAGAATGCTGGGCCCACAATCCAGCCTCCAGACTCACAGCATTGAGAATTAAGAAGACGCTTGCCAAGATGGTTGAA TCCCAAGATGTAAAAATCTGATGGTTAAACCATCGGAGGAGAAACTCTAGACTGCAAGAACTGTTTTTACCCATGGCATGGGTGGAATTA GAGTGGAATAAGGATGTTAACTTGGTTCTCAGACTCTTTCTTCACTACGTGTTCACAGGCTGCTAATATTAAACCTTTCAGTACTCTTAT TAGGATACAAGCTGGGAACTTCTAAACACTTCATTCTTTATATATGGACAGCTTTATTTTAAATGTGGTTTTTGATGCCTTTTTTTAAGT GGGTTTTTATGAACTGCATCAAGACTTCAATCCTGATTAGTGTCTCCAGTCAAGCTCTGGGTACTGAATTGCCTGTTCATAAAACGGTGC TTTCTGTGAAAGCCTTAAGAAGATAAATGAGCGCAGCAGAGATGGAGAAATAGACTTTGCCTTTTACCTGAGACTTTCAGTTCGTTTGTA TTCTACCTTTGTAAAACAGCCTATAGATGATGATGTGTTTGGGATACTGCTTATTTTATGATAGTTTGTCCTGTGTCCTTAGTGATGTGT GTGTGTCTCCATGCACATGCACGCCGGGATTCCTCTGCTGCCATTTGAATTAGAAGAAAATAATTTATATGCATGCACAGGAAGATATTG GTGGCCGGTGGTTTTGTGCTTTAAAAATGCAATATCTGACCAAGATTCGCCAATCTCATACAAGCCATTTACTTTGCAAGTGAGATAGCT TCCCCACCAGCTTTATTTTTTAACATGAAAGCTGATGCCAAGGCCAAAAGAAGTTTAAAGCATCTGTAAATTTGGACTGTTTTCCTTCAA CCACCATTTTTTTTGTGGTTATTATTTTTGTCACGGAAAGCATCCTCTCCAAAGTTGGAGCTTCTATTGCCATGAACCATGCTTACAAAG AAAGCACTTCTTATTGAAGTGAATTCCTGCATTTGATAGCAATGTAAGTGCCTATAACCATGTTCTATATTCTTTATTCTCAGTAACTTT TAAAAGGGAAGTTATTTATATTTTGTGTATAATGTGCTTTATTTGCAAATCACCCACTCCTTTACAACCATACTTTATATATGTACATAC ATTCATACTGTAGAAACCAGCTCATGTGTACCTCATATCCCATCCTTAAGAGAAGAAATGTTATAAAGTAGAACTAAATATAAATTTTCA GAATTAATGCATTCAAAGTAATATATCAAATCCAGGACTTTGTTAACTTCAGGTAAAAACTTCATTAGGGTAATATCATCTCAATTTTTT CAAATGAAAGGATTCTCTAATTAGAAATTTATATGTCAGAGCTGTTATAAATTTATCAACTGTCAAATATGTTCTGGACAGCTAAATCAT TTGAGATTTTTGGTTTTTTGATTTCTATTCCCTAACTTGTGAAGACAATGAAAAATCAGGCAGAAATATTTAGTATCTAGTCAGTATCTG TAGCTACACTGTATAACTGTTCTTCAATAAAATGGTTCATATTTTATAGATGCCTTGTTATCTCAAGAAATCTGATTTACATAAACTTAT ACTTCTTTAATGCTTTTTAAATATTTATTCTGAGCAAACAATTCATGAGTACATCAAGTGAGATAGTTTTATTTGATTATAACATAAAAT AAATGTGATTATATCACATCATCATCAAAAAGGTTTAAATTAAATGGGAGGAAATCAGCATATGTCCACCCATTACCAAAATTTGACTAT CATTTAAGGTTAAAACTTACAAATTTGTCTGCACATCAAATTTCACAAATTTGAAAATTGCCTTAACCATTTTGATTAATAAGTTTCATC TGCCATAATTAAAGTCTGAAGTGTTCATCAAGATAAGTAAATTTGCATATGGATAATACCCAATAACTTGTTTTTTCAGAATTTTTCACC ATATGTATACTGAGAAATACAAATATTTTAATCTGCGTTGCCGTATGATATGATTGCACTTAGAACACCCAATTTACTTAAATCTTGGTT TACTTTTGACTTGATACCATAATCTTTAAAATCATTTGTCATCTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCT GGACTGCGGACTGCAGTGGCGCAATCTCGGCTCACTGCAAGCTCCGCTTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAG CTGGGACTACAGGCGCCCGCCACCGCGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTAGCCAGGATGGTCTC AATCTCCTGACCTCATGATCCACCTGCCTCGGCCTCCCAAAGTTCATTTGTCATCTTAATAAAAATATAAAGACAGGCAAAGTTTATTGG AAATGTTCAAATGGTGTGTGGAAGCAAAAAATTACAGCCAGTATATGAGACCACTATTATGGTTTTTTAAAATTAACTTGGTCTAGTAAA AGTGATATCAAGAGTTAATCTTAGAAACTTGCTCAGTAAAAACATTTTCTAGTATAACATGTTCTTTAAAAAGCAAATGCTGCCGTCTTT GGAATCTTAATCTAAAAATGTGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCGGGTGGATCACAAGGT CAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAAAAAACTCAGCCAGGCGTGGTGGCGGGTGCCTGT AATCCCAGCTACTCGGGAGGCTGAAGCAGGAGAATTGCTTAAAATCAGAAGGTGGAGGTTGCAGTGAGCTGAGATCGTGTCACTGCACTC CAGCCTGGGCAAAAGAGCGAAACTCCATCTCAAATAAACAAACAAATAAATAACAAAAAACAAAAATGTTGCATTAAACTTAGTTCTTGT CTCTCCTTTCCACTCTTATTCTTAAATCTGAAGCTCATCGACTAAGTGAAATATTTAAAGAATATGATAGGCCAGCAAGAAGAAGTATTA TGTAGTACCATAGTTAGTAAATTCGTAAAACCTTGGAAGCCATTATTTGGTCCCACTTGCAATTTAGTGTTTTTGAAGTGTGTAGCTTCA TTCAGATAGCTCTTTAAATAATTAAAATATAAAAGCAAACAACCCAAACTACCTGACTATAAACAGGAAAAGTTAACCCTCAAAGAGAGT TCTTGTGAATTCTCTTTATGCTGGCAAATAGCTCTAGGATTAAAGGCACATTAGGGTTTCCTTCAGTTTGTTTATTCTAAGCTTTTACTG TGCTTTTTACTGAACAAGTTTCTGATGTATAAAACTTGCATCTGATTTCTTTGGAAATATTTTCACAAAAGTTATTTTAATCAGTATTTT TACATTGCCTTTCCAGTGTCCAGAAGTGTTTCTAAACTTAGAAAGTGACCTATAGTTTTTTAAAATTATGTTTTCCTAGAACGTGCCAAA TTTTGATTTACTCTAACAATCAGTACTTTTCTTCAGATGCTTTGTTCTGTTTAGAACAAAAATGCACTATAGTTTTTAAAGAATCATGCA TCTTTGGGTTGGCCCAGGATCAAATTTGATATTGAATAATTTATTCCAGGGCAGCTTTCATAAACATACTTCATAGATGTTGTTTTGAAA TGTTTCTAAATATCTAAAATCATTTCAACAGCAGAAATGATTTTTATTTTAACAAAAGATTATGATAGCCCTTGTAGTGTTTAAAAGTGG TCATATTTATTACTGACTTTGAGTCAGGTGTTAAAATAGCAGTGCCACAGCTCGTCTCTTGCCTTAGTGTGCTGCTGTGAGAGTCACAGT GGAAACTGCAGGGAGGAGGTGTGTTCCTAAGAACCAAAATCCAGCACAGCATCCTGTGAAGCCACGTGTAATGATGGTCCCATAAGGAAA GTATGTGAATATGGCTCTTGTAAAGGATTAACTATTGTAATTTTAGCTTATGCTCTGTATTCTGTTTTCTATGGAATTATTTAAGCCCTT TTAGTGACCTTTGTCCTGGCCCATTTAAAAACTAAAATGTAGTATATATTGTATAAAATGGAAATATCATTATTGCTTCATTAGGGGAAA CTGTACATAGGCATTGAAAGAAGGGTAAAAGCAAGCAGTTTTATCAGGCAGTTGTAAAACACCAAAAATATAGATTCGTCTTTGACGTGT AACACACTAAATGTATTTTGTACAGCATCTGGTTTAAAAGGTGCCTTAAGAGTTTACCATTACTTGCTTTGTTCTATATACAGATTATGT CCAATGTATCATTTTGAAGTAAATAACCTTATTTTAGTATACTTTAGTGATGTGTTTTGTGATGCTACACTCAGACGGTATTGTGCATCA GAAGTCATCTGTTGAGATTTTTGTAATGATTAAGTTAGTGTATATACATATGTTCCTGAGATGTACACTTCAACTACCAGAAACCCAGTA TGGAGCACAGGTAGGTACACGCTTGCCCTGTGGAGATAGAGAACTTCTAAACCTATCACGGTGCAGGGGTTTTTCCTTTAAAAAACAAGA CAAAACATTGTTTTCTTTTTCCTTTTTTTTTTTTTTTTTTTGAGACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCACGAT CTCAGCTCACTGCAACCTTTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAATAGCTGGAACTACAGGTGTTTGCCACCA TGCCTGGCTAATTTTTTGTATTTTTAATAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGGCCCAC TTGCCTTGGCCTCCCAAAGTGCTGAGCTTACAGGCATGAGCCACCATGCCTGGCCAAAACATTGTTTTCTGATTATGGAAATGTACTCAT GGCAGAAAATTTGGGAAACAACAGCAAATAATAAAGCAAATAAAAATCACTCAAAATTCTATTGCCAGACATTATCACTATATACATTTG AGTGTTTCTTTTCAATCTTTTTTTTTGAGAGAGTCTTGCTCTGTCACTCAGGGTGGAGTGCAGTAGCGCGATCTCGGCTCAGTGCAACCT CTGCCCCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCCGGGATTACAGGTGTGCACCACCACGCCCGGCTAATTTTTGT ATTTTAGTAGAGATGCGGTTTCACCATGTTGGCCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCTGCCTACCTCAGCCTCCCAAAG TGCTGGGATTACAGGAGTGAGCCACTGCACCCGGCCTTATTCTTTTTTATGTTGCATTTTTTGTAATATTAGGATCCTAGTATGCCATTA AATAGCCATTGAGAACTTTTTTTTTAATGACTGCACAATATTTGACTAAGAAGATGGAGTAATTTCTGTGCTCAATCCCCTATTGAATAT TTGGATTATTTTCATTGTTTTGAAAAATAGATATTAAGCATCCTTATACATAAATCTTTATTTTCTTATATTACATTTCTGAAAATGAGA CTAGTGGATATGAACTTTTAAAAGATCCTTTAAGATGGAAAAACTAAGGTTCTTGGAAAACATTGCCATATTGCTACTCACAAAGCTTTT CATTTTCATTCCTGCTAGCAGTTCATGAGCTTAGAGCGATGGGATGCATTTACCTGGCCTTAAGATGCTCCTGCTGCAATGGGAAGTGAA GCCTTGGATAGCTTTCCTCCTCCTGTGCAATACTTTCTTGTCATTTTCCCACCTGCACTGAGTCCCACCGCCAGTCAGGGCTGTTTTCAG GTGTATGTGAATTCATCCCAGCAGTGTGCCTTCTGCTGCCTTTTCCTAGGGAACTGAACATGTTAAATCACAGACGCGATGTGGCACTGA TTATTGTTCCTCAAAAGAAATGCGTGTCTGAAGATAGCCTCTTACAGATTCCTCACGGGAGTCTCTGTTCAGTGTCATTGTAAGTTTCTC AGAATAATCGCAGGCGCTCTGATGCAGCCTGGTAAAGAAGACTCAGTGATTTCTGGGAACTGCAAATGCTTGCCAGCTTTCCTTCTGTCT GTGGAAACACTGAATAAATGTATTCATTTCTCCTTTCCAGCAATCTGTTAGTCTCACTGCTCCATTCCAAGGTTTCTTTAATATTATTAA CAGAGCAGACATTAAGAAACAGAATTGTCTAATCCTTGTTCTTCCAAAATAGGTTTAATCCTTGTAGATAGTTTCAAGCAGACAGTAAGT CAGTTACTAAGTTTTCACTTGGAGAAACATTTGCTGATAGTAGTAGCATATTGACCATTTCTGACATGTCATCCTTATATCAAGTTAGGT GCACGCTCCTACACAGCCTTGGCTCAGCGCTTGGAGCATACAGTCTTGACTGGGTGGACATAAACCGCTGAAAGTGGCCAGCAGTGAGCA GAGGCCACCTACTATCAGCGGCACTGCTGCAGGCATGGAGACTTAAATGTGTGAGTGCTGGTATAAGCAGAAGTGGGAGAGTCACCTCGA TGCTGGGATCCAGATGGCGGCTTATTTCAAGTGCAGTGGCACATACAAAAAATATTTTTGGAAGGGAGCAAGGACTAGGGCTGAAAGGTT CATTCATAATCTTTTTTTCTTTTTTTTTTTAGGTGGAGTCTCGCTCTGTCACCCAGGCTGGAGCGCAATGGGGTGATCCCAGCTCACTGC AACCTCCACCTCCCGGGTTAAAGCAATTCTCCTGCCTCAGCCACCTGAGAAGTTGGGATTACAGGCGTGCACCACCACACTCAGCTAATT TTGTATTTTTAGTAGAGACGGGGTTTACCATGTGGGCCAGGCTGGTCTCGAACTCCCAACCTCAGGTGATCTGCCCACCTTGGCCTTCCA GAGTGCTGGGATTATAGGCGTGAGCCACTGCGCCCAGCCCATAATCTCCTTTTGACATAGGAATTGTTAATTCACATATTCCATCAACCT ATTGCTCCTCTGAATCTTAGCAGCTTCTTGGTCTTTGTTCAAATGAAATCTAAGTCAATTCCATATCTCTCAATGTCGCTACATCCACCT CAGTGCTTATATCCTAATTTTGTCTTTTTTAGAGACAGTCTTGCACTGTCACCCAGGCTAGTGTGCAGTGGCTGTTCACAGGCATAATCA TAACGCACTGTAGCCTCAAACTCCTGATCTCAAGCCATCCTCCCACCTCAGCCTCCTGAGTAGCTGGGACCATGCCACCATGCCTGGCTC ACATTCTAAACATTATGCAGGAAGCTCAAAGTGAAAATCAATATGGAATGTTTATATTGAAAATATTTTTGGCTGGGTGCAGTGGCTAAT GCCTCTAATCCCAGCACTCTGGGAGGCTGAGGCGGGCAGACCACCTGAGGTCAGGAGCAGCCTGGCCAACATATAGTGAAACCCTGTCTC TAAGGTACAAAAATTAGCTGGGTGTGGTGGTACTCGCCTGTAGTCCCAGCTCCTTGGGAAGCTGAGGCAGGAGAATCACTTGAACCCAGG AGGCGGAGGTTGCAGTGAGCTGAGATCGCACCACTGCATTCCAGGCTGGGCAACAGAGCAAGACTCCGTCTCTCAAAAAAAAAAAAAGAA AAAAAAATATATATATATATATACACACACACACACACACATATATATATATATATTCAAGCAATGTGAAGAAAATATTGGGCCCCCTTG TTTTTCTTTAATGGAAGAGCCATTTTTAAAAGCCAGTTTAGAATCCAGATGATGACATCTGTTGCTCTACTGTATGACTGAAATGCAGGT CAGTGTTGAAAAACATAAAAAATTGGAAGTCTCCACTGAAAGACCTACACTGCTGTGGGAGGGATTTTAATCAAGACATTTCAAAAGCAA TTTTTATTACTTGATCCTGTCCTCATACTTGGCTAGGAGTTCAGCTGGAGATAGAATCTAACTCTGAAGATGATACTCCATGATCTTCTA GCATCCCTTGTCACCAGTGAGAAGTCTGATGTGGATCTAATAAGTGACATGTTATACAGGTTAACTTATTTTCAAGAAATAGAATTTTCT TTTTATTATTGATGTTGGAAGTTGAAACTGGCCATATCTAAATATATTCATTCTGTTTCTTAGTACTAATGGGATCTTTTCTTAGACCTG GGAAATTTTCTCCCATTATTTCTTTTGTTTCTTCCCTTTTTTCTTTCTTTTCCTTTTCTCTTTCTAGAACTTTCTAGAACAAATCTCAGG TCCCCTAGATGTTTCTTCCATAATTGTTACTATGCTTCTCATATGTTTCATCCTACCTTCTACTTTTGTCAGCCCATCTGAGTTTATTTC AACAGCCAAATGTTTTATTTTGAAATGATTCCAGGCTTCCATTAAAGTTTCATCAATAGTATAAGGACTGCCATTTACCCTTCACCCAGA TTCATAAACTGCTAACATTGCACAATTGCTTTGTCATTCTGTGTGTGTGTGTACAGGAATCACAGAGACTCATCTTGTAATGTTTGTAAT GTCCATGTATCGTGTATGCACACATTTTTTTCTGACCTATTAGAAGCAAATTACAGAGCTAATACCCCTTTATCCCTAAATACTTCAGGG ATGTTCTATTACTTAACCAATTATGTACAATTATCAGAACCAGGAAAGTTCACATTGATACAATAGCAATGACCAACAATACCATAATCT ATAGACCTTACTGAAGTTTTGCTAATTGTTATTTTGGTGTGGTTGGGTTTTTTGTTTGTTTGAGATAGGGTCTCACTCTGTCACCCAGGC TGGAGTACAGTGGCACAGTCATAGCTCACTTCAACCTCAAACTTTGGGCCTCAAGCGATCCTCCCGCCTCAGCCTCCCAAAGGGCTATGA TTACAGGCATGAGCCACCATGCTGGCCTCATTTCCCCTTTCCTTCTCAAAAGGATTCTGGCTTTCCCTACTGCATTCATCCACGTCCACT ACCCGCTCCAAGAGAGCTGAGTAATTGTCAAGCCAGGTTTGGGGAGCTTTCTTGATGGAGGGGATGGAAGGAGGGTGGTGCTCAGGCTAC AGCAGGGAGAGCTTTTCTGTTTTTGAGCTAAAGACATAACAGGGTGCAGAGGCTGAGAAAAGGAGAGTTCTAAGCAACATGTCACGAGCT >29013_29013_2_FAM35A-BMPR1A_FAM35A_chr10_88912636_ENST00000298786_BMPR1A_chr10_88649819_ENST00000372037_length(amino acids)=1018AA_BP=508 MSGGSQVHIFWGAPIAPLKITVSEDTASLMSVADPWKKIQLLYSQHSLYLKDEKQHKNLENYKVPESIGSPDLSGHFLANCMNRHVHVKD DFVRSVSETQNIESQKIHSSRLSDITSSNMQICGFKSTVPHFTEEEKYQKLLSENKIRDEQPKHQPDICGKNFNTNLFQLGHKCAAVLDL VCSTEKINIGPEVVQRECVPTEYHEIQNQCLGLFSSNAVDKSRSEAAVRKVSDLKISTDTEFLSIITSSQVAFLAQKKDKRRSPVNKGNV NMETEPKASYGEIRIPEENSIQLDGFTEAYESGQNQAYSLELFSPVCPKTENSRIHINSDKGLEEHTGSQELFSSEDELPPNEIRIELCS SGILCSQLNTFHKSAIKRSCTSEDKVGQSEALSRVLQVAKKMKLISNGGDSAVEMDRRNVSEFKSIKKTSLIKNCDSKSQKYNCLVMVLS PCHVKEINIKFGPNSGSKVPLATVTVIDQSETKKKVFLWRTAAFWAFTVFLGDIILLTGQNLDSMLHGTGMKSDSDQKKSENGVTLAPED TLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIG PFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQI QMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCA TLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLD ESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECW -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for FAM35A-BMPR1A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for FAM35A-BMPR1A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for FAM35A-BMPR1A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C0345893 | Juvenile polyposis syndrome | 12 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
| Tgene | C1832940 | JUVENILE POLYPOSIS OF STOMACH | 5 | CLINGEN;CTD_human;ORPHANET | |
| Tgene | C1868081 | Juvenile Polyposis Coli | 5 | CLINGEN;CTD_human;ORPHANET | |
| Tgene | C0015393 | Eye Abnormalities | 1 | CTD_human | |
| Tgene | C0376634 | Craniofacial Abnormalities | 1 | CTD_human | |
| Tgene | C1720887 | Female Urogenital Diseases | 1 | CTD_human | |
| Tgene | C1832587 | POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 | 1 | ORPHANET | |
| Tgene | C1864730 | Polyposis Syndrome, Hereditary Mixed, 2 | 1 | CTD_human;GENOMICS_ENGLAND | |
| Tgene | C2677290 | COLORECTAL CANCER, SUSCEPTIBILITY TO, 4 | 1 | ORPHANET | |
| Tgene | C2677291 | COLORECTAL CANCER, SUSCEPTIBILITY TO, ON CHROMOSOME 15 | 1 | ORPHANET | |
| Tgene | C3896578 | Familial Colorectal Cancer Type X | 1 | ORPHANET |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies