Fusion Gene Studies
in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARL15-ITGA1 (FusionGDB2 ID:HG54622TG3672)

Fusion Gene Summary for ARL15-ITGA1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARL15-ITGA1
Fusion gene ID: hg54622tg3672
HgeneTgene
Gene symbol

ARL15

ITGA1

Gene ID

54622

3672

Gene nameADP ribosylation factor like GTPase 15integrin subunit alpha 1
SynonymsARFRP2CD49a|VLA1
Cytomap('ARL15')('ITGA1')

5q11.2

5q11.2

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor-like protein 15ADP-ribosylation factor-like 15ADP-ribosylation factor-related protein 2ARF-related protein 2integrin alpha-1CD49 antigen-like family member AVLA-1laminin and collagen receptorvery late activation protein 1
Modification date2020031320200313
UniProtAcc.

P56199

Ensembl transtripts involved in fusion geneENST00000504924, ENST00000507646, 
ENST00000502271, ENST00000510591, 
Fusion gene scores* DoF score18 X 13 X 7=16383 X 3 X 2=18
# samples 183
** MAII scorelog2(18/1638*10)=-3.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARL15 [Title/Abstract] AND ITGA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARL15(53409032)-ITGA1(52243175), # samples:2
Anticipated loss of major functional domain due to fusion event.ARL15-ITGA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARL15-ITGA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARL15-ITGA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARL15-ITGA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneITGA1

GO:0032516

positive regulation of phosphoprotein phosphatase activity

15592458


check buttonFusion gene breakpoints across ARL15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ITGA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-HS-A5N8-01AARL15chr5

53409032

-ITGA1chr5

52243175

+


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Fusion Gene ORF analysis for ARL15-ITGA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000504924ENST00000504086ARL15chr5

53409032

-ITGA1chr5

52243175

+
5CDS-intronENST00000507646ENST00000504086ARL15chr5

53409032

-ITGA1chr5

52243175

+
5UTR-3CDSENST00000502271ENST00000282588ARL15chr5

53409032

-ITGA1chr5

52243175

+
5UTR-3CDSENST00000510591ENST00000282588ARL15chr5

53409032

-ITGA1chr5

52243175

+
5UTR-intronENST00000502271ENST00000504086ARL15chr5

53409032

-ITGA1chr5

52243175

+
5UTR-intronENST00000510591ENST00000504086ARL15chr5

53409032

-ITGA1chr5

52243175

+
In-frameENST00000504924ENST00000282588ARL15chr5

53409032

-ITGA1chr5

52243175

+
In-frameENST00000507646ENST00000282588ARL15chr5

53409032

-ITGA1chr5

52243175

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000504924ARL15chr553409032-ENST00000282588ITGA1chr552243175+74775561717238
ENST00000507646ARL15chr553409032-ENST00000282588ITGA1chr552243175+74805591720239

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000504924ENST00000282588ARL15chr553409032-ITGA1chr552243175+0.0013598750.9986401
ENST00000507646ENST00000282588ARL15chr553409032-ITGA1chr552243175+0.0013603490.99863964

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Fusion Genomic Features for ARL15-ITGA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARL15chr553409031-ITGA1chr552243174+0.0001119950.99988794
ARL15chr553409031-ITGA1chr552243174+0.0001119950.99988794

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARL15-ITGA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:53409032/chr5:52243175)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ITGA1

P56199

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. {ECO:0000269|PubMed:15592458}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARL15chr5:53409032chr5:52243175ENST00000504924-45142_145154205.0Nucleotide bindingGTP
HgeneARL15chr5:53409032chr5:52243175ENST00000504924-4539_46154205.0Nucleotide bindingGTP
HgeneARL15chr5:53409032chr5:52243175ENST00000504924-4582_86154205.0Nucleotide bindingGTP
TgeneITGA1chr5:53409032chr5:52243175ENST0000028258826291167_117111261180.0MotifNote=GFFKR motif
TgeneITGA1chr5:53409032chr5:52243175ENST0000028258826291165_117911261180.0Topological domainCytoplasmic
TgeneITGA1chr5:53409032chr5:52243175ENST0000028258826291142_116411261180.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneITGA1chr5:53409032chr5:52243175ENST000002825882629498_50611261180.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA1chr5:53409032chr5:52243175ENST000002825882629580_58811261180.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA1chr5:53409032chr5:52243175ENST000002825882629642_65011261180.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA1chr5:53409032chr5:52243175ENST000002825882629161_36011261180.0DomainVWFA
TgeneITGA1chr5:53409032chr5:52243175ENST000002825882629101_16011261180.0RepeatFG-GAP 2
TgeneITGA1chr5:53409032chr5:52243175ENST00000282588262930_9111261180.0RepeatFG-GAP 1
TgeneITGA1chr5:53409032chr5:52243175ENST000002825882629365_41711261180.0RepeatFG-GAP 3
TgeneITGA1chr5:53409032chr5:52243175ENST000002825882629422_47511261180.0RepeatFG-GAP 4
TgeneITGA1chr5:53409032chr5:52243175ENST000002825882629476_53811261180.0RepeatFG-GAP 5
TgeneITGA1chr5:53409032chr5:52243175ENST000002825882629557_61511261180.0RepeatFG-GAP 6
TgeneITGA1chr5:53409032chr5:52243175ENST000002825882629619_67911261180.0RepeatFG-GAP 7
TgeneITGA1chr5:53409032chr5:52243175ENST00000282588262929_114111261180.0Topological domainExtracellular


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Fusion Gene Sequence for ARL15-ITGA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6562_6562_1_ARL15-ITGA1_ARL15_chr5_53409032_ENST00000504924_ITGA1_chr5_52243175_ENST00000282588_length(transcript)=7477nt_BP=556nt
GTTGCTGGCTTTTTCAGGAGCTGCTCGCTCGCAGCCAGAGACGCTGCTTTTTTTTTCCGGGTTCGGAGCCGTTCCGGATGCTTTAGGCTG
CCGGATGTCTGATCTCCGAATAACTGAGGCGTTTCTGTACATGGATTATCTGTGTTTTAGAGCACTTTGCTGCAAGGGACCACCACCTGC
ACGACCAGAATATGACCTGGTTTGCATAGGCCTCACAGGTTCTGGCAAAACCAGTCTGTTGTCCAAACTCTGCAGTGAAAGCCCCGATAA
CGTCGTGTCGACCACAGGTTTTAGTATTAAAGCAGTGCCATTCCAGAATGCCATCTTGAATGTAAAAGAACTTGGAGGGGCTGATAACAT
CCGGAAATACTGGAGCCGCTACTACCAAGGATCTCAAGGGGTAATATTTGTATTAGACAGTGCCTCTTCAGAGGATGATTTAGAAGCTGC
TAGAAATGAGCTGCACTCAGCTCTTCAGCATCCACAGTTATGCACTTTACCCTTTTTAATATTGGCCAATCATCAAGACAAGCCAGCAGC
TCGCTCAGTACAAGAGCTTGCTATTCAAATATCCAAAGATGGGCTACCGGGCAGAGTGCCATTATGGGTCATCCTGCTGAGTGCTTTTGC
CGGATTGTTGCTGTTAATGCTGCTCATTTTAGCACTGTGGAAGATTGGATTCTTCAAAAGACCACTGAAAAAGAAAATGGAGAAATGAAA
TATTTTATGAAAGAAAATAATAACAATTATTCAATAATCTATCCTCAGGTTTGCCTCAAATATGTGACAAGAAATGTATAATTCATGACA
TAGTCATGTAACTATGTAATCCATCAGGGATTCATTACTTGGAAAATGACAGGTCATGCATTATCCAAAAACAATACCAAAAAGACATAT
TTTATAAAATGACAAAAAATATTTTACATAATTACTCATTTTTGTTGAGTAAGCAAAATTACAAAGTGTTTTTAAAAAAACCTGTACAAA
TATGTTTATGTATTAAATCACCATCCAAAATATTTAAGGAATATATAAAAAGATTTTTATGATCATAGAAACATCTATTTTCAAAACAAT
ATAAATTAAGCTTTTCCCCTTGATTCCTGTTGGATATCCATGTTCAGCATGACAGTCAGCACTCGTAAATGCCAAGAAAAGAATTACCTG
AAAAAGATCATTTCTCCCTATTCAAATGAGAATATTTTCCCTTGGTAGAATCCATATACAATATGGATTGAAAATTAAGTCACCAAGAAT
ACATTTAGCATCTTTGTGTTGGGTTCTATACCTAAAAATTTTCCCTCCCTGCCCAAGGTGATTGGAAAGTACTGCAATTGAGCTAAAATT
TTATCTAGGATGGAAAATCAGGATAGACTCGTTTAAAAACAAGTATATTAAATGGGTTAAATTAAGCTTTTACAGAACATGCTTAATTTT
GATATTGAGCTCTAAATGCAAAACTCTTTTATACTGAAAAAACACTTAAAGTAGTTTTGTGTGGCATCACAGTGATTTGTCATGAAAAGC
CATATATGGGGGACATGCTAAAATGGCTTCTGAATGAAATACGACAGCAGAGAAAGATGCCACTGAAATGCTGAAATTATCTTTGCTGAG
CAGCTTTTGAATGCTAAGGGTTCCAGTATGTGACCCAAAGAAAGAGTTGTCTCAACTCCTTGGTACAGGGTTCATTCAAACCCCCAAGCT
GTGAGAGTGTGTTTATTTTTAATTTTTTAAAAGGTATTTAATTTCCAACCACACTTCTTATTTTTTTGAAAAGACAATTTTCCATTTCAG
TATTACATTTTACCAAGAAGTCACTGCTTTTTAGGTGTGTTGCATCAATATTTAAATAAAATCCCAGAAATGTATTTTAAAGAATTTCAG
GTTTGAAAACTCAAACCAACAGGAAGATATCACACCTTTGTATGTGCTTCTTTGTTCTTGAAGTAGTCATTATGGTTCATTGGAATCTAC
TGTAGCATAAGCTCCTAGGTTGCTCCATTTCTTAGGAAAATAGCAATGAATGAATGTATAGTAGCTGCATGTGTGAACTACTGCTGTAAA
GTTTGCTGACATTTCTGCAACAACATTTCTCCATCTGATTTACCAGAACCTGTAACAAGACCAGAACATGTATTCATCCAGAAACTCCTG
GGCTCTGCTTTGTTCAAAGAGGAGCAAATCCACATAGAAATTAAATGTTATAAATTTATTTTTTTAAACTAATTTCCAAAGAATTTAGCT
GAAGACTCAGAGTCAGCCTACCTCTTGACTCTCCACATCCGCATCTAAGATCCTGAAGGCCAAAGGAATGCGCCTGTGGGATGCCAAAGC
CATCAGTAGCTGGAAGAAAGAATACCTCTTTCTAGAGGTTTGGTGTCCTCTTGCTGGCCTGTCATTATTTGGAAATACGCGCTTTTGGAA
TTTCCTTCATTTTCGCTATTTCCAGGTTCAGAAATCATACCTACCACTTGTTCTTTCTTTGCCCAGTAAAACTCAGGGTTTCTCTTATTC
AGAGTTACCATGTTGCACACCCCCAGTGCTCAGCCTGCCCAGAAGCCCTTCTCTGATCTCAGCAAGATCTTAGTAGTAAAGCTAACGGAT
CCATTGAAATTCATACTCAGCATCTGTGACTACTAGACAAAGCCCATTTACTGAACCATAAGTGTGCACTTTTAAACTAAATTGTTAACT
GAAAGGGAAAAAATAGAAATGAGGGCATTTTGAAGTTTTTAGAAAAGAGAGGAAGAGCTGTTGGCCAGATCAAAGAGATACTTATAAGCC
CGGCACAATTTTTAACATAAGTCATTCCTGGCTATTAAGTAAAATATTTCATGAACCAGAAGTCCTGTTTCTCTAATATTATAATTTGTT
GAGGTTTGTGTGTGTGTGTGTGTGCATGTGCAGACACATGTACACATATAAATTGAATACAAAAATAGCTCTATAACACCAAAAAACAGA
GTTTACAGAAAATAAACACAAAAGCTATATCTGCAAGACAAGTTTGATTCATCTAGTTTCATATAGTTTCATATAGTTTCATTTTTATTA
ATATTTAGGTTTAACTTATAGTTCTGCAATTATTTAAAAAACAAGTACAGAGCGTTTGATTAAAAAAAGTCAACAAATGTTTCAAAACAG
CTTTGTACAAATGTTATAAAACATATTTAATGATTAAGAAATGTACTAGACTCTATCATTTACTTTTAAAACATTTAATTAGAAAAACAG
GTGATATTTAAGACTATTTATAAACTTATTGGCCAAATTGCCAAAAAGTTTCTTTTTCTCTAACTTTGGTATTCTAAATAATTGATTATT
GCTCCCATTGTAAACTGAACCATGTATGCACTCTCTTTTCTGACCAAACTACAATGGTATATTGGTAAATTATTTAACAACACACTGTCC
AGGAGGGAAAAAAAAAACAGTCTCTGATTTGTATCATTTGCCAATTTCCATGGTCCAAATATTCTCTCTCCATTTTCAAACTACCAAAGT
GACCCTAATCAGCTTACAAAATTCCTGGAAATGTATCTGCCACCTCTTACCAACCAGTGTGAGCTGACTTCAGCACACCACTGAGACAGA
TTACACGATAGACAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATATTGATAGAGAACATGTTGTGTCTATATA
CATATCCAATGACACACAGTATAATCATGTTTTAAATTATGCCAAAAGTACTGATTATATCAAGCCCAGTAAACATAATGCTACACAGCA
CCCATTCTTTAATTTTGATTTCTAAAATTATAACCTTCCTTTGATATTAATAAAATGTTATGAACTTGCAGGAGAAGGAAGGAGTTGAAA
GAAGGAAAATATAAAGGGTGATCCACAGTGAAAATCAGACCTACACAAGCCACAAAAAAATTGTCTCATTTTCCCAAGGAATTCAAAGTC
CTGTGATACACATTACAAAAGATGACACTTTGTAAATATTTTGAACTTCTATGATCCAATTTCAACTTCATTGGTCCAATTTGTCAAACT
ATTTTCCTCTGAGCACTAGATTCATGGGCAATTTAATCTCTGAATATTTTCTGTGTCATAAGTGTGCTTGAAAAGAGGCTTGTAGTAAAC
AGATATTTTTACAAAATTTGATGCTTCTGCAACCATAATAATTTTATCTATAAATGCGTATATACATATATATATATATATATATACACA
TACACTCACATGCAGATATTTACATATATAGATATTCTCTTTTCCTTTTATAAAATCAAAGTCTAGGCTCAATTGGAAAATGGAAATATT
TGCACCAAAAGAAAAAAGTGCCATTGTTGTGATCAATGGAGTAAAGCTGGGGTATAGTAGAGGCTGGGGAATCCCTGCCCATGTTCTCTC
CAAGGCCACAGCTTGCACACCGTGAATGGTGGCCCCACTGGCTCCATGGAGTGTGCCTTCACGCGGGGGAATGTCCTTGTCCAACACGCT
GTAATCTACTCCATGGGAACTGACTGTCCTGCTTTTCACAACATTGAGAAACAGGCCCAGAGCCTGTCTCATGTGCCAGGTGCAGTCACA
TTATTGTTAAAATAAAGTGGCTTCTGACAAATCAGTTTTTCAAAATAGCATCCTATGTACTTTTCATTTCTTCCAACAACCCTCAGGCCC
CCTTTTGCCAGTTTTCTCCCCCAGGGGAGATTTTCAAGACTACTGGAGAAAAATCTGTTAATAAAACATTTGCTCTGAGTACCAGCTTCA
GTGACTCAATCATTTATACAGGATTTCAGTGTTTTGTTCTGCAGCGGTGTTCTAAAGGGTTCACATAGTATAATGGAGGAGGGACAAAGC
AGAATATACTTCCAAGCTGGAACATCTTTAAGACATTTACAAACTGTTATGGGACACTATCAGCAACTACGCCTGGGGAAGCTAGCAGGA
TTTAGCTCTTCAATGGCCCTCCAAATGCACCCAACAATCGCCAACCTCACCCATGGAAATCATCTAAAAAATGAAAAGAAGGGCCTTAAA
GTCCTCACATGGATGCTGTATTTATAACTAAAATGTACAGTTTAATTCTAAATAGCAGGCTTTTAAATGCAAACAGCTTCCAGGTGAGTC
CTCTGGCTGCCAATCAGACTGCTGATTCTAAACCATTCTCACACAGAATTTCTGAAACCAACACCAGGTATTAATTGTTAACTGCAGTGA
AAGGAAACCAAGGCACATTACAAAAGGCTAAATGCTGCTGTTTCTAAGTGGAAGCACTGTTGAACAACACTCTTAGGTGGAATAAGAAAA
TTAGGGTTAAACTGTAACATTGTAATCGGACGAACAAATCAGCATCTTTGATCCTCAGGTTAAAATTTAATCTTAAATTTAGAAATTCAA
AGTAACAGCCTTTAACCATTAACCTTGAGGAAAATGTGAAGTAGCATCTGGAGTCTCTTAAGCCCCAGCCCTGTTGTCCCCTACAGCATC
TCCACCCAGGAAGTCCAGTTCCTAACTAATGGGAATGGATCCTTTTCCCATTATAAAGGGCCGATGCTTAACCCTTGAACCCACTACTGT
TCTTATGCCCCAAGATCTGCACCTTACATCAGGCACCCGGGAATGCTTCTCATTGAAATTTTACCATACCAAAAAATATGTAAGGGTGAC
TCATCACTCCTAACTTTGGACTCCTTGCTTTGAGATCGGTATTTTTTTCTCTCTCTTTACATATAGCAAAAGCTTTCCCCAGTAGCTGAT
GAATTTAGAACTTTATACAAGACTCCCTAGCATTTTCCTCCTCCCACAGGCTGGAGAATTTCAGTGCTATGAGACTGGGCAGTAGGAGCC
AGAGCCAATTTGCAGGATCTCTTTTCCTTCTGCCTTCCAGTTGGCTTCTCTTCTCAGCTGCGTGGTGGGGATGATTTGGGGTTTCCTCAG
CAAGGCCATTCTCTGCCTTGTGCCCATAGCAGGGCCTTGGGTGGTGACATGTTATCTTTGTTGGTGAGCAGACACTCAGAGATCCTTTAA
TTATCTGACACACCAGGGAAATCTTGGCAATCAACTAAGGACCTGTGACACTCATAACTATGTTTACATTTGGCTTTAGCATATTTCAGG
TAATATCTTTATGAAAAAAAGATGAAGTATGGAATTGTAGGAACTCTTTTGCAATAGACTGAGATCCAATGTTTAAATCTTTTTATTTCA
GTTTGATCTGTGCCTTTAGATTGGGGACAAAATTTTAAAAACAAATCTTCCAAATGACACCACAATGAAAGCCAGTTGTGGTCTTGAAAA
ATCTCTCTATTGCATTACTTATCCTCACCCTTGTTTTTTAAGAGGTAGAGAGAGATTACTGGGAAGCAGTGAGCCAACATAATTGTCCTT
TCCTCTACAGAATAGCTGTGCAGAAGGGGACCACCACACTTAGGACCAGTGCCAGGTGACAATCTTTCCGTCATGCTGCTGCAGCATTTT
GCACCTTGAGAGACAGGAAAAAAAATGGGGGTGAGGGAGTGGAAGATGATGAAACTATTTCTCTTTTATGTCTACATCCTTACTCCTCAA
AATACTTTAAGCTCACTCAGACCCCATATACCCTGCCCACAATACTAACACATGTACTTTGCATAAGTAAATTGTTGATTAAATAAGAGC
AAAACTATATTCTTATGTGTAGATTAACCAAGGCTAATTTCCTGGAGTTTAATACACTTTGGATTCAAGTAAAAACAATCACTTAATGCA
GCAACATCTCAGACCCTCTTCACTCTAGAACCGTTTTATACAAGAGAACTCAACATTTACTGTTTTATTTCTGATATTGCCTGCCATTAC
TCAGGATGCAAGAGATGCTCTGCATTCCTTATTAGGAAAAATTGGCCTGTAAGGAGAATGGTATACTGCGTATTACTACTGTGAGACTGT
AAAATTGTTAATGGACAGTGTAAAGAATTGTATTCATTTTATTAGCAAGAAAAATATTGCATACAAGAACTACTGCCCTGAAATATCCAT
CACTCCAATGAACTGTTCTGCCTGATCTAACATAAAGTTATATTTCATTGCTCATTTTTTTTTGCCTCACTAAAATGACTAACTTAAGGG
AATGTGCATTTCTACAAGACTTTAATTGGATAAACTCATTAGAAGAAAATGTTTCGATTGCATTCAGGAACAAAGAAGCATAACCTTTGT
TGACTCTTGTAATTTATTATATGCTTCATTTAAACCCATTTTGTAAAGAAATCAGGTAACAGTCATTTAATCTGATATAATTAGAAATAG
CTGAGAGAGTAAAAAAGCATTTTGAATGTCCTATGTATGGCATATCCTGTACACCAATTGAAGGTCAGAGCTTTGGTATTTTTGTATAAT
TCTGTCTTATCTGGTGCATCAGCTGTGTATTTTACGTCAAGGTAAATGAGCATCCTGTTTTATATGTTAAATTTTAAAAATGACTTTTTC

>6562_6562_1_ARL15-ITGA1_ARL15_chr5_53409032_ENST00000504924_ITGA1_chr5_52243175_ENST00000282588_length(amino acids)=238AA_BP=185
LLAFSGAARSQPETLLFFSGFGAVPDALGCRMSDLRITEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDN
VVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLEAARNELHSALQHPQLCTLPFLILANHQDKPAA

--------------------------------------------------------------
>6562_6562_2_ARL15-ITGA1_ARL15_chr5_53409032_ENST00000507646_ITGA1_chr5_52243175_ENST00000282588_length(transcript)=7480nt_BP=559nt
GCTGTTGCTGGCTTTTTCAGGAGCTGCTCGCTCGCAGCCAGAGACGCTGCTTTTTTTTTCCGGGTTCGGAGCCGTTCCGGATGCTTTAGG
CTGCCGGATGTCTGATCTCCGAATAACTGAGGCGTTTCTGTACATGGATTATCTGTGTTTTAGAGCACTTTGCTGCAAGGGACCACCACC
TGCACGACCAGAATATGACCTGGTTTGCATAGGCCTCACAGGTTCTGGCAAAACCAGTCTGTTGTCCAAACTCTGCAGTGAAAGCCCCGA
TAACGTCGTGTCGACCACAGGTTTTAGTATTAAAGCAGTGCCATTCCAGAATGCCATCTTGAATGTAAAAGAACTTGGAGGGGCTGATAA
CATCCGGAAATACTGGAGCCGCTACTACCAAGGATCTCAAGGGGTAATATTTGTATTAGACAGTGCCTCTTCAGAGGATGATTTAGAAGC
TGCTAGAAATGAGCTGCACTCAGCTCTTCAGCATCCACAGTTATGCACTTTACCCTTTTTAATATTGGCCAATCATCAAGACAAGCCAGC
AGCTCGCTCAGTACAAGAGCTTGCTATTCAAATATCCAAAGATGGGCTACCGGGCAGAGTGCCATTATGGGTCATCCTGCTGAGTGCTTT
TGCCGGATTGTTGCTGTTAATGCTGCTCATTTTAGCACTGTGGAAGATTGGATTCTTCAAAAGACCACTGAAAAAGAAAATGGAGAAATG
AAATATTTTATGAAAGAAAATAATAACAATTATTCAATAATCTATCCTCAGGTTTGCCTCAAATATGTGACAAGAAATGTATAATTCATG
ACATAGTCATGTAACTATGTAATCCATCAGGGATTCATTACTTGGAAAATGACAGGTCATGCATTATCCAAAAACAATACCAAAAAGACA
TATTTTATAAAATGACAAAAAATATTTTACATAATTACTCATTTTTGTTGAGTAAGCAAAATTACAAAGTGTTTTTAAAAAAACCTGTAC
AAATATGTTTATGTATTAAATCACCATCCAAAATATTTAAGGAATATATAAAAAGATTTTTATGATCATAGAAACATCTATTTTCAAAAC
AATATAAATTAAGCTTTTCCCCTTGATTCCTGTTGGATATCCATGTTCAGCATGACAGTCAGCACTCGTAAATGCCAAGAAAAGAATTAC
CTGAAAAAGATCATTTCTCCCTATTCAAATGAGAATATTTTCCCTTGGTAGAATCCATATACAATATGGATTGAAAATTAAGTCACCAAG
AATACATTTAGCATCTTTGTGTTGGGTTCTATACCTAAAAATTTTCCCTCCCTGCCCAAGGTGATTGGAAAGTACTGCAATTGAGCTAAA
ATTTTATCTAGGATGGAAAATCAGGATAGACTCGTTTAAAAACAAGTATATTAAATGGGTTAAATTAAGCTTTTACAGAACATGCTTAAT
TTTGATATTGAGCTCTAAATGCAAAACTCTTTTATACTGAAAAAACACTTAAAGTAGTTTTGTGTGGCATCACAGTGATTTGTCATGAAA
AGCCATATATGGGGGACATGCTAAAATGGCTTCTGAATGAAATACGACAGCAGAGAAAGATGCCACTGAAATGCTGAAATTATCTTTGCT
GAGCAGCTTTTGAATGCTAAGGGTTCCAGTATGTGACCCAAAGAAAGAGTTGTCTCAACTCCTTGGTACAGGGTTCATTCAAACCCCCAA
GCTGTGAGAGTGTGTTTATTTTTAATTTTTTAAAAGGTATTTAATTTCCAACCACACTTCTTATTTTTTTGAAAAGACAATTTTCCATTT
CAGTATTACATTTTACCAAGAAGTCACTGCTTTTTAGGTGTGTTGCATCAATATTTAAATAAAATCCCAGAAATGTATTTTAAAGAATTT
CAGGTTTGAAAACTCAAACCAACAGGAAGATATCACACCTTTGTATGTGCTTCTTTGTTCTTGAAGTAGTCATTATGGTTCATTGGAATC
TACTGTAGCATAAGCTCCTAGGTTGCTCCATTTCTTAGGAAAATAGCAATGAATGAATGTATAGTAGCTGCATGTGTGAACTACTGCTGT
AAAGTTTGCTGACATTTCTGCAACAACATTTCTCCATCTGATTTACCAGAACCTGTAACAAGACCAGAACATGTATTCATCCAGAAACTC
CTGGGCTCTGCTTTGTTCAAAGAGGAGCAAATCCACATAGAAATTAAATGTTATAAATTTATTTTTTTAAACTAATTTCCAAAGAATTTA
GCTGAAGACTCAGAGTCAGCCTACCTCTTGACTCTCCACATCCGCATCTAAGATCCTGAAGGCCAAAGGAATGCGCCTGTGGGATGCCAA
AGCCATCAGTAGCTGGAAGAAAGAATACCTCTTTCTAGAGGTTTGGTGTCCTCTTGCTGGCCTGTCATTATTTGGAAATACGCGCTTTTG
GAATTTCCTTCATTTTCGCTATTTCCAGGTTCAGAAATCATACCTACCACTTGTTCTTTCTTTGCCCAGTAAAACTCAGGGTTTCTCTTA
TTCAGAGTTACCATGTTGCACACCCCCAGTGCTCAGCCTGCCCAGAAGCCCTTCTCTGATCTCAGCAAGATCTTAGTAGTAAAGCTAACG
GATCCATTGAAATTCATACTCAGCATCTGTGACTACTAGACAAAGCCCATTTACTGAACCATAAGTGTGCACTTTTAAACTAAATTGTTA
ACTGAAAGGGAAAAAATAGAAATGAGGGCATTTTGAAGTTTTTAGAAAAGAGAGGAAGAGCTGTTGGCCAGATCAAAGAGATACTTATAA
GCCCGGCACAATTTTTAACATAAGTCATTCCTGGCTATTAAGTAAAATATTTCATGAACCAGAAGTCCTGTTTCTCTAATATTATAATTT
GTTGAGGTTTGTGTGTGTGTGTGTGTGCATGTGCAGACACATGTACACATATAAATTGAATACAAAAATAGCTCTATAACACCAAAAAAC
AGAGTTTACAGAAAATAAACACAAAAGCTATATCTGCAAGACAAGTTTGATTCATCTAGTTTCATATAGTTTCATATAGTTTCATTTTTA
TTAATATTTAGGTTTAACTTATAGTTCTGCAATTATTTAAAAAACAAGTACAGAGCGTTTGATTAAAAAAAGTCAACAAATGTTTCAAAA
CAGCTTTGTACAAATGTTATAAAACATATTTAATGATTAAGAAATGTACTAGACTCTATCATTTACTTTTAAAACATTTAATTAGAAAAA
CAGGTGATATTTAAGACTATTTATAAACTTATTGGCCAAATTGCCAAAAAGTTTCTTTTTCTCTAACTTTGGTATTCTAAATAATTGATT
ATTGCTCCCATTGTAAACTGAACCATGTATGCACTCTCTTTTCTGACCAAACTACAATGGTATATTGGTAAATTATTTAACAACACACTG
TCCAGGAGGGAAAAAAAAAACAGTCTCTGATTTGTATCATTTGCCAATTTCCATGGTCCAAATATTCTCTCTCCATTTTCAAACTACCAA
AGTGACCCTAATCAGCTTACAAAATTCCTGGAAATGTATCTGCCACCTCTTACCAACCAGTGTGAGCTGACTTCAGCACACCACTGAGAC
AGATTACACGATAGACAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATATTGATAGAGAACATGTTGTGTCTAT
ATACATATCCAATGACACACAGTATAATCATGTTTTAAATTATGCCAAAAGTACTGATTATATCAAGCCCAGTAAACATAATGCTACACA
GCACCCATTCTTTAATTTTGATTTCTAAAATTATAACCTTCCTTTGATATTAATAAAATGTTATGAACTTGCAGGAGAAGGAAGGAGTTG
AAAGAAGGAAAATATAAAGGGTGATCCACAGTGAAAATCAGACCTACACAAGCCACAAAAAAATTGTCTCATTTTCCCAAGGAATTCAAA
GTCCTGTGATACACATTACAAAAGATGACACTTTGTAAATATTTTGAACTTCTATGATCCAATTTCAACTTCATTGGTCCAATTTGTCAA
ACTATTTTCCTCTGAGCACTAGATTCATGGGCAATTTAATCTCTGAATATTTTCTGTGTCATAAGTGTGCTTGAAAAGAGGCTTGTAGTA
AACAGATATTTTTACAAAATTTGATGCTTCTGCAACCATAATAATTTTATCTATAAATGCGTATATACATATATATATATATATATATAC
ACATACACTCACATGCAGATATTTACATATATAGATATTCTCTTTTCCTTTTATAAAATCAAAGTCTAGGCTCAATTGGAAAATGGAAAT
ATTTGCACCAAAAGAAAAAAGTGCCATTGTTGTGATCAATGGAGTAAAGCTGGGGTATAGTAGAGGCTGGGGAATCCCTGCCCATGTTCT
CTCCAAGGCCACAGCTTGCACACCGTGAATGGTGGCCCCACTGGCTCCATGGAGTGTGCCTTCACGCGGGGGAATGTCCTTGTCCAACAC
GCTGTAATCTACTCCATGGGAACTGACTGTCCTGCTTTTCACAACATTGAGAAACAGGCCCAGAGCCTGTCTCATGTGCCAGGTGCAGTC
ACATTATTGTTAAAATAAAGTGGCTTCTGACAAATCAGTTTTTCAAAATAGCATCCTATGTACTTTTCATTTCTTCCAACAACCCTCAGG
CCCCCTTTTGCCAGTTTTCTCCCCCAGGGGAGATTTTCAAGACTACTGGAGAAAAATCTGTTAATAAAACATTTGCTCTGAGTACCAGCT
TCAGTGACTCAATCATTTATACAGGATTTCAGTGTTTTGTTCTGCAGCGGTGTTCTAAAGGGTTCACATAGTATAATGGAGGAGGGACAA
AGCAGAATATACTTCCAAGCTGGAACATCTTTAAGACATTTACAAACTGTTATGGGACACTATCAGCAACTACGCCTGGGGAAGCTAGCA
GGATTTAGCTCTTCAATGGCCCTCCAAATGCACCCAACAATCGCCAACCTCACCCATGGAAATCATCTAAAAAATGAAAAGAAGGGCCTT
AAAGTCCTCACATGGATGCTGTATTTATAACTAAAATGTACAGTTTAATTCTAAATAGCAGGCTTTTAAATGCAAACAGCTTCCAGGTGA
GTCCTCTGGCTGCCAATCAGACTGCTGATTCTAAACCATTCTCACACAGAATTTCTGAAACCAACACCAGGTATTAATTGTTAACTGCAG
TGAAAGGAAACCAAGGCACATTACAAAAGGCTAAATGCTGCTGTTTCTAAGTGGAAGCACTGTTGAACAACACTCTTAGGTGGAATAAGA
AAATTAGGGTTAAACTGTAACATTGTAATCGGACGAACAAATCAGCATCTTTGATCCTCAGGTTAAAATTTAATCTTAAATTTAGAAATT
CAAAGTAACAGCCTTTAACCATTAACCTTGAGGAAAATGTGAAGTAGCATCTGGAGTCTCTTAAGCCCCAGCCCTGTTGTCCCCTACAGC
ATCTCCACCCAGGAAGTCCAGTTCCTAACTAATGGGAATGGATCCTTTTCCCATTATAAAGGGCCGATGCTTAACCCTTGAACCCACTAC
TGTTCTTATGCCCCAAGATCTGCACCTTACATCAGGCACCCGGGAATGCTTCTCATTGAAATTTTACCATACCAAAAAATATGTAAGGGT
GACTCATCACTCCTAACTTTGGACTCCTTGCTTTGAGATCGGTATTTTTTTCTCTCTCTTTACATATAGCAAAAGCTTTCCCCAGTAGCT
GATGAATTTAGAACTTTATACAAGACTCCCTAGCATTTTCCTCCTCCCACAGGCTGGAGAATTTCAGTGCTATGAGACTGGGCAGTAGGA
GCCAGAGCCAATTTGCAGGATCTCTTTTCCTTCTGCCTTCCAGTTGGCTTCTCTTCTCAGCTGCGTGGTGGGGATGATTTGGGGTTTCCT
CAGCAAGGCCATTCTCTGCCTTGTGCCCATAGCAGGGCCTTGGGTGGTGACATGTTATCTTTGTTGGTGAGCAGACACTCAGAGATCCTT
TAATTATCTGACACACCAGGGAAATCTTGGCAATCAACTAAGGACCTGTGACACTCATAACTATGTTTACATTTGGCTTTAGCATATTTC
AGGTAATATCTTTATGAAAAAAAGATGAAGTATGGAATTGTAGGAACTCTTTTGCAATAGACTGAGATCCAATGTTTAAATCTTTTTATT
TCAGTTTGATCTGTGCCTTTAGATTGGGGACAAAATTTTAAAAACAAATCTTCCAAATGACACCACAATGAAAGCCAGTTGTGGTCTTGA
AAAATCTCTCTATTGCATTACTTATCCTCACCCTTGTTTTTTAAGAGGTAGAGAGAGATTACTGGGAAGCAGTGAGCCAACATAATTGTC
CTTTCCTCTACAGAATAGCTGTGCAGAAGGGGACCACCACACTTAGGACCAGTGCCAGGTGACAATCTTTCCGTCATGCTGCTGCAGCAT
TTTGCACCTTGAGAGACAGGAAAAAAAATGGGGGTGAGGGAGTGGAAGATGATGAAACTATTTCTCTTTTATGTCTACATCCTTACTCCT
CAAAATACTTTAAGCTCACTCAGACCCCATATACCCTGCCCACAATACTAACACATGTACTTTGCATAAGTAAATTGTTGATTAAATAAG
AGCAAAACTATATTCTTATGTGTAGATTAACCAAGGCTAATTTCCTGGAGTTTAATACACTTTGGATTCAAGTAAAAACAATCACTTAAT
GCAGCAACATCTCAGACCCTCTTCACTCTAGAACCGTTTTATACAAGAGAACTCAACATTTACTGTTTTATTTCTGATATTGCCTGCCAT
TACTCAGGATGCAAGAGATGCTCTGCATTCCTTATTAGGAAAAATTGGCCTGTAAGGAGAATGGTATACTGCGTATTACTACTGTGAGAC
TGTAAAATTGTTAATGGACAGTGTAAAGAATTGTATTCATTTTATTAGCAAGAAAAATATTGCATACAAGAACTACTGCCCTGAAATATC
CATCACTCCAATGAACTGTTCTGCCTGATCTAACATAAAGTTATATTTCATTGCTCATTTTTTTTTGCCTCACTAAAATGACTAACTTAA
GGGAATGTGCATTTCTACAAGACTTTAATTGGATAAACTCATTAGAAGAAAATGTTTCGATTGCATTCAGGAACAAAGAAGCATAACCTT
TGTTGACTCTTGTAATTTATTATATGCTTCATTTAAACCCATTTTGTAAAGAAATCAGGTAACAGTCATTTAATCTGATATAATTAGAAA
TAGCTGAGAGAGTAAAAAAGCATTTTGAATGTCCTATGTATGGCATATCCTGTACACCAATTGAAGGTCAGAGCTTTGGTATTTTTGTAT
AATTCTGTCTTATCTGGTGCATCAGCTGTGTATTTTACGTCAAGGTAAATGAGCATCCTGTTTTATATGTTAAATTTTAAAAATGACTTT

>6562_6562_2_ARL15-ITGA1_ARL15_chr5_53409032_ENST00000507646_ITGA1_chr5_52243175_ENST00000282588_length(amino acids)=239AA_BP=186
LLLAFSGAARSQPETLLFFSGFGAVPDALGCRMSDLRITEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPD
NVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLEAARNELHSALQHPQLCTLPFLILANHQDKPA

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Fusion Gene PPI Analysis for ARL15-ITGA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARL15-ITGA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARL15-ITGA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneC0017639Gliosis1CTD_human
TgeneC3887640Astrocytosis1CTD_human