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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARL15-CDC42SE2 (FusionGDB2 ID:HG54622TG56990)

Fusion Gene Summary for ARL15-CDC42SE2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARL15-CDC42SE2
Fusion gene ID: hg54622tg56990
HgeneTgene
Gene symbol

ARL15

CDC42SE2

Gene ID

54622

56990

Gene nameADP ribosylation factor like GTPase 15CDC42 small effector 2
SynonymsARFRP2SPEC2
Cytomap('ARL15')('CDC42SE2')

5q11.2

5q31.1

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor-like protein 15ADP-ribosylation factor-like 15ADP-ribosylation factor-related protein 2ARF-related protein 2CDC42 small effector protein 2non-kinase Cdc42 effector protein SPEC2small effector of CDC42 protein 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000504924, ENST00000507646, 
ENST00000502271, ENST00000510591, 
Fusion gene scores* DoF score18 X 13 X 7=16388 X 9 X 3=216
# samples 1810
** MAII scorelog2(18/1638*10)=-3.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/216*10)=-1.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARL15 [Title/Abstract] AND CDC42SE2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARL15(53409032)-CDC42SE2(130721236), # samples:1
Anticipated loss of major functional domain due to fusion event.ARL15-CDC42SE2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARL15-CDC42SE2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCDC42SE2

GO:0009966

regulation of signal transduction

10816584


check buttonFusion gene breakpoints across ARL15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CDC42SE2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A134-01AARL15chr5

53409032

-CDC42SE2chr5

130721236

+


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Fusion Gene ORF analysis for ARL15-CDC42SE2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000504924ENST00000360515ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5CDS-5UTRENST00000504924ENST00000503291ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5CDS-5UTRENST00000504924ENST00000505065ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5CDS-5UTRENST00000507646ENST00000360515ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5CDS-5UTRENST00000507646ENST00000503291ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5CDS-5UTRENST00000507646ENST00000505065ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5CDS-intronENST00000504924ENST00000504701ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5CDS-intronENST00000507646ENST00000504701ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5UTR-3CDSENST00000502271ENST00000395246ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5UTR-3CDSENST00000510591ENST00000395246ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5UTR-5UTRENST00000502271ENST00000360515ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5UTR-5UTRENST00000502271ENST00000503291ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5UTR-5UTRENST00000502271ENST00000505065ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5UTR-5UTRENST00000510591ENST00000360515ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5UTR-5UTRENST00000510591ENST00000503291ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5UTR-5UTRENST00000510591ENST00000505065ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5UTR-intronENST00000502271ENST00000504701ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
5UTR-intronENST00000510591ENST00000504701ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
In-frameENST00000504924ENST00000395246ARL15chr5

53409032

-CDC42SE2chr5

130721236

+
In-frameENST00000507646ENST00000395246ARL15chr5

53409032

-CDC42SE2chr5

130721236

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000504924ARL15chr553409032-ENST00000395246CDC42SE2chr5130721236+35445561756251
ENST00000507646ARL15chr553409032-ENST00000395246CDC42SE2chr5130721236+35475591759252

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000504924ENST00000395246ARL15chr553409032-CDC42SE2chr5130721236+0.0004822850.9995177
ENST00000507646ENST00000395246ARL15chr553409032-CDC42SE2chr5130721236+0.000482940.9995171

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Fusion Genomic Features for ARL15-CDC42SE2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARL15chr553409031-CDC42SE2chr5130721235+5.22E-060.99999475
ARL15chr553409031-CDC42SE2chr5130721235+5.22E-060.99999475

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARL15-CDC42SE2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:53409032/chr5:130721236)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARL15chr5:53409032chr5:130721236ENST00000504924-45142_145154205.0Nucleotide bindingGTP
HgeneARL15chr5:53409032chr5:130721236ENST00000504924-4539_46154205.0Nucleotide bindingGTP
HgeneARL15chr5:53409032chr5:130721236ENST00000504924-4582_86154205.0Nucleotide bindingGTP
TgeneCDC42SE2chr5:53409032chr5:130721236ENST000003605152620_2318978.6666666666666Compositional biasNote=Poly-Arg
TgeneCDC42SE2chr5:53409032chr5:130721236ENST000003952461520_2318955.6666666666666Compositional biasNote=Poly-Arg
TgeneCDC42SE2chr5:53409032chr5:130721236ENST000005050652520_231885.0Compositional biasNote=Poly-Arg
TgeneCDC42SE2chr5:53409032chr5:130721236ENST000003605152629_4218978.6666666666666DomainCRIB
TgeneCDC42SE2chr5:53409032chr5:130721236ENST000003952461529_4218955.6666666666666DomainCRIB
TgeneCDC42SE2chr5:53409032chr5:130721236ENST000005050652529_421885.0DomainCRIB

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARL15-CDC42SE2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6560_6560_1_ARL15-CDC42SE2_ARL15_chr5_53409032_ENST00000504924_CDC42SE2_chr5_130721236_ENST00000395246_length(transcript)=3544nt_BP=556nt
GTTGCTGGCTTTTTCAGGAGCTGCTCGCTCGCAGCCAGAGACGCTGCTTTTTTTTTCCGGGTTCGGAGCCGTTCCGGATGCTTTAGGCTG
CCGGATGTCTGATCTCCGAATAACTGAGGCGTTTCTGTACATGGATTATCTGTGTTTTAGAGCACTTTGCTGCAAGGGACCACCACCTGC
ACGACCAGAATATGACCTGGTTTGCATAGGCCTCACAGGTTCTGGCAAAACCAGTCTGTTGTCCAAACTCTGCAGTGAAAGCCCCGATAA
CGTCGTGTCGACCACAGGTTTTAGTATTAAAGCAGTGCCATTCCAGAATGCCATCTTGAATGTAAAAGAACTTGGAGGGGCTGATAACAT
CCGGAAATACTGGAGCCGCTACTACCAAGGATCTCAAGGGGTAATATTTGTATTAGACAGTGCCTCTTCAGAGGATGATTTAGAAGCTGC
TAGAAATGAGCTGCACTCAGCTCTTCAGCATCCACAGTTATGCACTTTACCCTTTTTAATATTGGCCAATCATCAAGACAAGCCAGCAGC
TCGCTCAGTACAAGAGAAAAGGCGACGGCGGATTGACAGAAGTATGATTGGAGAGCCCACAAACTTTGTGCATACAGCTCATGTTGGATC
AGGAGACCTGTTCAGTGGAATGAATTCAGTTAGCTCCATTCAGAACCAAATGCAGTCCAAGGGAGGTTATGGAGGTGGAATGCCTGCCAA
TGTCCAGATGCAGCTCGTGGATACGAAGGCGGGATAGCCCTGGTCCTTTCTCCAAAGTGTGATGGCACCTTGTCCACCCTGTCGTGATTA
TTCCAGTGAGATGTTACTGTTCTGCTCTGAAGAAGATACTGTCAGACGAATCCTGCATTTCCTTCAGCTGGCATGCATGCCTTTGGACTC
ATGGACAGAGTTCTTTGGATTGTCACTGAATTTTCAATGTTTAATCAGTATGGATCTGATCTTCGCATGATCTTTTTTGTGAATGCTAAC
ACCATTTTGCAGTTTTTTTTTTCTATTTTAAACATTTTTCTTTTCACTGCCGACCCCCTGCCTTACGATTTTATTGGAAAGCAAGGACCT
GCTATTATTTGTTAATTTGCCATCATTTATGTATATTTTGGAAGGTATGAGACCCACAAGCACAATGATCATTTTTATTTGTTTGTTTGT
TTGAAACTTCAGCAGAATAGATATCTGCATGCTTTATGAAGTTGTTGCTTCGGTAAGAGCCCATGGGATGCCAGAAATTAACATTTCTTT
GCTGCCATGGGCTGATGATGCTGCTATTAGATAAAGTTTAGCTGTGGCACCAAGTCACATCATTTTCATAGAAAAAGATTACTTGTAGCT
TATTTTAGAAGTATGACCTTTTGGTCTGTTTGATTGATTGATTAGAATTGCAATAAAAGAAAAGCTTGCATTCATAAGGCATTCATTCTG
TTGTAAATGTTCAATATATTTATTTTGAGAGCAAGGACCTGTGGTTGTAAACAGGTGTGGTTACAGGTGTGGTTATGTATCTGAGTGTTG
CGGTCATACTCTCCTCCAGTCCAATCCTGAGCATCTTCATCTTATTAATTAGCTGTTCGTTTCTTTGTGCACTCATTCTTTTATTTTTAC
TTCTTTTTAATGTTATGGTATCCAGTTGTTTCCAGTAGCAGTTTCTTGAACTTCTGGCCTGTACTACTAACTGCAGACCTCCAGAGTCAC
TGGCCTTTCTGTGCTCTACATATTATTTTAGGGGCCACATCAGTTGCCAAGAGCAACATACATACCGACCTGGCTGAATTATTGCCAGTG
AAAACAACCTGTACGAAGCCTTTGCTCAGGTTCTAAAATATGTTTGTCCTTGCACGAATTTTGTATATTTCAAATATTTCTGTAAAGGTT
TCTTCTTTTCTGTTAGAGTGTGGTGTTAAGCCAGAGTCAGTGGTTTGTGTTCTCATTAAAATGTTTGTTTAAATCCTATGTCCAATTCAA
GCCTATCTAACTACATTTGGTAGGATTAACATTTCATATAACAAATGGGGCTTAATTAAAAACTTTAACTTGGAATAAAGGAACAGGGAT
CACTTTATCTTCTGCCTTCATTTACCTTAGTCCAAGATTCTTGCAAAACAGGCAACTGAACAAACATTAGGTTTATGTAGGTAAAATGTG
AAAGCATTTCTCCTCCACTTTTTAAAATTTAATTTACCCAGTACAGCGGGGCACCAGATTACTTGATCTTTGTATTTTGCAGTTTTGAGC
CTTTGTGTCAATCCCAAGCACAGAGAGGATCTGCCAAGGAAAAACATTTGCATCTTCGGAGTAGACATTTTGCAGTTTGTTTAATAACAA
CTTCTAAAGTAAGTTGAATTCATCCATTGTCACTGATTCACCAAGTGGATGTTGCATTGTGGAATTTGCCTGAGTACTGTTGTCATTCTG
CTCAGCCAGGCACGGTCAGTTTCTTGGCCAGGGACATTGCTATGTGCTGTGTGCAAGCTCTTTAGAAGAGAGATTGGATTTTCTTGGCAT
TATCAGCACTCATGCTATTTAGTCTACTTCTATTTTGACTGACTCTTTAAATTAGTACAATTTTTCTACTTGTCATATAACTCCTGGAAC
AATAGTACGGGAAGCCGTGATCCTTTTCCCTGACTCATGATTTTAGTCTTTTTCCAAATCGCTGTTTTTTTTTTTTTTTTTTTTTTTTTT
GCTGCTCCAACGACCAGCATGTGTTGGAGCAGATCTCCATGGTAAGCCAAAAGTGGACTTGTCAGCCTATAACTACTCTGCAGCTGCCAC
TAACTCTACAGGCACAGTAACTACACTTTATACAGGAGCACATGCCAAAGTGCCTGGGAGGTGCCAATAAAATCAAGAAATAAGAAAACT
ACAAAAAAAGATACGGTATTAACCTTGGACATAATTTTTTTTAGGGAGGCAGCTTTCCCACTTTTATAAAGGGGGTTGTAAATCTCAAGA
GGTCATTTGTTCCCCATAGCAGCATATCTCATTTTTAAATTGAAGCGAATTAAATAGGATTTTACTACTCAACATTCATTATACTGTTAA
TCTTTGCTGAAATATATGCTAACAAATGTTAAGCAAGGGAAACTGAAGACTTAGTCATGTGGATTGTTAGCAGTGATCTGCATTCTGTAA
AAGAGGTACTTTCCCATGATGTAGGCATGAAGTGGTGCCAGTAAGCGTAGAGCGGAAATGTTGACTTTAGTTAACATTGGGTTTAGCATT
TCCAGTGCAGCATTATCAGTGGGCCTTTAAAAATACTTCGTAAGTACATTAGCTTTCACTTTGTTGTTAAATTATAGCAGACTCATTATA
GAGAACAAGTTTGCCTTGATTTTGTTTAAAATGACTTCTGCTAAGCACCCAGAAGATAAAATTGACATATTTTTATAATATAAGCATACT
TTTTTTGTACATTGTGTTCATTCTTGAATAAAATGAGTTCTGTGTTGGCTTGTAGATACTAAAAAGAAAGTATTGATTTTGATTCAATAA

>6560_6560_1_ARL15-CDC42SE2_ARL15_chr5_53409032_ENST00000504924_CDC42SE2_chr5_130721236_ENST00000395246_length(amino acids)=251AA_BP=185
LLAFSGAARSQPETLLFFSGFGAVPDALGCRMSDLRITEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDN
VVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLEAARNELHSALQHPQLCTLPFLILANHQDKPAA

--------------------------------------------------------------
>6560_6560_2_ARL15-CDC42SE2_ARL15_chr5_53409032_ENST00000507646_CDC42SE2_chr5_130721236_ENST00000395246_length(transcript)=3547nt_BP=559nt
GCTGTTGCTGGCTTTTTCAGGAGCTGCTCGCTCGCAGCCAGAGACGCTGCTTTTTTTTTCCGGGTTCGGAGCCGTTCCGGATGCTTTAGG
CTGCCGGATGTCTGATCTCCGAATAACTGAGGCGTTTCTGTACATGGATTATCTGTGTTTTAGAGCACTTTGCTGCAAGGGACCACCACC
TGCACGACCAGAATATGACCTGGTTTGCATAGGCCTCACAGGTTCTGGCAAAACCAGTCTGTTGTCCAAACTCTGCAGTGAAAGCCCCGA
TAACGTCGTGTCGACCACAGGTTTTAGTATTAAAGCAGTGCCATTCCAGAATGCCATCTTGAATGTAAAAGAACTTGGAGGGGCTGATAA
CATCCGGAAATACTGGAGCCGCTACTACCAAGGATCTCAAGGGGTAATATTTGTATTAGACAGTGCCTCTTCAGAGGATGATTTAGAAGC
TGCTAGAAATGAGCTGCACTCAGCTCTTCAGCATCCACAGTTATGCACTTTACCCTTTTTAATATTGGCCAATCATCAAGACAAGCCAGC
AGCTCGCTCAGTACAAGAGAAAAGGCGACGGCGGATTGACAGAAGTATGATTGGAGAGCCCACAAACTTTGTGCATACAGCTCATGTTGG
ATCAGGAGACCTGTTCAGTGGAATGAATTCAGTTAGCTCCATTCAGAACCAAATGCAGTCCAAGGGAGGTTATGGAGGTGGAATGCCTGC
CAATGTCCAGATGCAGCTCGTGGATACGAAGGCGGGATAGCCCTGGTCCTTTCTCCAAAGTGTGATGGCACCTTGTCCACCCTGTCGTGA
TTATTCCAGTGAGATGTTACTGTTCTGCTCTGAAGAAGATACTGTCAGACGAATCCTGCATTTCCTTCAGCTGGCATGCATGCCTTTGGA
CTCATGGACAGAGTTCTTTGGATTGTCACTGAATTTTCAATGTTTAATCAGTATGGATCTGATCTTCGCATGATCTTTTTTGTGAATGCT
AACACCATTTTGCAGTTTTTTTTTTCTATTTTAAACATTTTTCTTTTCACTGCCGACCCCCTGCCTTACGATTTTATTGGAAAGCAAGGA
CCTGCTATTATTTGTTAATTTGCCATCATTTATGTATATTTTGGAAGGTATGAGACCCACAAGCACAATGATCATTTTTATTTGTTTGTT
TGTTTGAAACTTCAGCAGAATAGATATCTGCATGCTTTATGAAGTTGTTGCTTCGGTAAGAGCCCATGGGATGCCAGAAATTAACATTTC
TTTGCTGCCATGGGCTGATGATGCTGCTATTAGATAAAGTTTAGCTGTGGCACCAAGTCACATCATTTTCATAGAAAAAGATTACTTGTA
GCTTATTTTAGAAGTATGACCTTTTGGTCTGTTTGATTGATTGATTAGAATTGCAATAAAAGAAAAGCTTGCATTCATAAGGCATTCATT
CTGTTGTAAATGTTCAATATATTTATTTTGAGAGCAAGGACCTGTGGTTGTAAACAGGTGTGGTTACAGGTGTGGTTATGTATCTGAGTG
TTGCGGTCATACTCTCCTCCAGTCCAATCCTGAGCATCTTCATCTTATTAATTAGCTGTTCGTTTCTTTGTGCACTCATTCTTTTATTTT
TACTTCTTTTTAATGTTATGGTATCCAGTTGTTTCCAGTAGCAGTTTCTTGAACTTCTGGCCTGTACTACTAACTGCAGACCTCCAGAGT
CACTGGCCTTTCTGTGCTCTACATATTATTTTAGGGGCCACATCAGTTGCCAAGAGCAACATACATACCGACCTGGCTGAATTATTGCCA
GTGAAAACAACCTGTACGAAGCCTTTGCTCAGGTTCTAAAATATGTTTGTCCTTGCACGAATTTTGTATATTTCAAATATTTCTGTAAAG
GTTTCTTCTTTTCTGTTAGAGTGTGGTGTTAAGCCAGAGTCAGTGGTTTGTGTTCTCATTAAAATGTTTGTTTAAATCCTATGTCCAATT
CAAGCCTATCTAACTACATTTGGTAGGATTAACATTTCATATAACAAATGGGGCTTAATTAAAAACTTTAACTTGGAATAAAGGAACAGG
GATCACTTTATCTTCTGCCTTCATTTACCTTAGTCCAAGATTCTTGCAAAACAGGCAACTGAACAAACATTAGGTTTATGTAGGTAAAAT
GTGAAAGCATTTCTCCTCCACTTTTTAAAATTTAATTTACCCAGTACAGCGGGGCACCAGATTACTTGATCTTTGTATTTTGCAGTTTTG
AGCCTTTGTGTCAATCCCAAGCACAGAGAGGATCTGCCAAGGAAAAACATTTGCATCTTCGGAGTAGACATTTTGCAGTTTGTTTAATAA
CAACTTCTAAAGTAAGTTGAATTCATCCATTGTCACTGATTCACCAAGTGGATGTTGCATTGTGGAATTTGCCTGAGTACTGTTGTCATT
CTGCTCAGCCAGGCACGGTCAGTTTCTTGGCCAGGGACATTGCTATGTGCTGTGTGCAAGCTCTTTAGAAGAGAGATTGGATTTTCTTGG
CATTATCAGCACTCATGCTATTTAGTCTACTTCTATTTTGACTGACTCTTTAAATTAGTACAATTTTTCTACTTGTCATATAACTCCTGG
AACAATAGTACGGGAAGCCGTGATCCTTTTCCCTGACTCATGATTTTAGTCTTTTTCCAAATCGCTGTTTTTTTTTTTTTTTTTTTTTTT
TTTGCTGCTCCAACGACCAGCATGTGTTGGAGCAGATCTCCATGGTAAGCCAAAAGTGGACTTGTCAGCCTATAACTACTCTGCAGCTGC
CACTAACTCTACAGGCACAGTAACTACACTTTATACAGGAGCACATGCCAAAGTGCCTGGGAGGTGCCAATAAAATCAAGAAATAAGAAA
ACTACAAAAAAAGATACGGTATTAACCTTGGACATAATTTTTTTTAGGGAGGCAGCTTTCCCACTTTTATAAAGGGGGTTGTAAATCTCA
AGAGGTCATTTGTTCCCCATAGCAGCATATCTCATTTTTAAATTGAAGCGAATTAAATAGGATTTTACTACTCAACATTCATTATACTGT
TAATCTTTGCTGAAATATATGCTAACAAATGTTAAGCAAGGGAAACTGAAGACTTAGTCATGTGGATTGTTAGCAGTGATCTGCATTCTG
TAAAAGAGGTACTTTCCCATGATGTAGGCATGAAGTGGTGCCAGTAAGCGTAGAGCGGAAATGTTGACTTTAGTTAACATTGGGTTTAGC
ATTTCCAGTGCAGCATTATCAGTGGGCCTTTAAAAATACTTCGTAAGTACATTAGCTTTCACTTTGTTGTTAAATTATAGCAGACTCATT
ATAGAGAACAAGTTTGCCTTGATTTTGTTTAAAATGACTTCTGCTAAGCACCCAGAAGATAAAATTGACATATTTTTATAATATAAGCAT
ACTTTTTTTGTACATTGTGTTCATTCTTGAATAAAATGAGTTCTGTGTTGGCTTGTAGATACTAAAAAGAAAGTATTGATTTTGATTCAA

>6560_6560_2_ARL15-CDC42SE2_ARL15_chr5_53409032_ENST00000507646_CDC42SE2_chr5_130721236_ENST00000395246_length(amino acids)=252AA_BP=186
LLLAFSGAARSQPETLLFFSGFGAVPDALGCRMSDLRITEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPD
NVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLEAARNELHSALQHPQLCTLPFLILANHQDKPA

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Fusion Gene PPI Analysis for ARL15-CDC42SE2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARL15-CDC42SE2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARL15-CDC42SE2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0036341Schizophrenia2PSYGENET