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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DNAJB12-NEK5 (FusionGDB2 ID:HG54788TG341676) |
Fusion Gene Summary for DNAJB12-NEK5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DNAJB12-NEK5 | Fusion gene ID: hg54788tg341676 | Hgene | Tgene | Gene symbol | DNAJB12 | NEK5 | Gene ID | 54788 | 341676 |
| Gene name | DnaJ heat shock protein family (Hsp40) member B12 | NIMA related kinase 5 | |
| Synonyms | DJ10 | - | |
| Cytomap | ('DNAJB12')('NEK5') 10q22.1 | 13q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dnaJ homolog subfamily B member 12DnaJ (Hsp40) homolog, subfamily B, member 12 | serine/threonine-protein kinase Nek5NIMA (never in mitosis gene a)-related kinase 5nimA-related protein kinase 5 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9NXW2 | Q6P3R8 | |
| Ensembl transtripts involved in fusion gene | ENST00000338820, ENST00000394903, ENST00000444643, ENST00000461919, | ||
| Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 3 X 3 X 3=27 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DNAJB12 [Title/Abstract] AND NEK5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DNAJB12(74114523)-NEK5(52650279), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | DNAJB12-NEK5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DNAJB12-NEK5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DNAJB12 | GO:0034622 | cellular protein-containing complex assembly | 27916661 |
| Hgene | DNAJB12 | GO:0036503 | ERAD pathway | 21148293|21150129 |
| Hgene | DNAJB12 | GO:0051085 | chaperone cofactor-dependent protein refolding | 27916661 |
| Hgene | DNAJB12 | GO:0071218 | cellular response to misfolded protein | 21148293|21150129 |
| Fusion gene breakpoints across DNAJB12 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across NEK5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-8284-01A | DNAJB12 | chr10 | 74114523 | - | NEK5 | chr13 | 52650279 | - |
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Fusion Gene ORF analysis for DNAJB12-NEK5 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000338820 | ENST00000529080 | DNAJB12 | chr10 | 74114523 | - | NEK5 | chr13 | 52650279 | - |
| 5CDS-intron | ENST00000394903 | ENST00000529080 | DNAJB12 | chr10 | 74114523 | - | NEK5 | chr13 | 52650279 | - |
| 5CDS-intron | ENST00000444643 | ENST00000529080 | DNAJB12 | chr10 | 74114523 | - | NEK5 | chr13 | 52650279 | - |
| In-frame | ENST00000338820 | ENST00000355568 | DNAJB12 | chr10 | 74114523 | - | NEK5 | chr13 | 52650279 | - |
| In-frame | ENST00000394903 | ENST00000355568 | DNAJB12 | chr10 | 74114523 | - | NEK5 | chr13 | 52650279 | - |
| In-frame | ENST00000444643 | ENST00000355568 | DNAJB12 | chr10 | 74114523 | - | NEK5 | chr13 | 52650279 | - |
| intron-3CDS | ENST00000461919 | ENST00000355568 | DNAJB12 | chr10 | 74114523 | - | NEK5 | chr13 | 52650279 | - |
| intron-intron | ENST00000461919 | ENST00000529080 | DNAJB12 | chr10 | 74114523 | - | NEK5 | chr13 | 52650279 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000394903 | DNAJB12 | chr10 | 74114523 | - | ENST00000355568 | NEK5 | chr13 | 52650279 | - | 1516 | 385 | 241 | 864 | 207 |
| ENST00000338820 | DNAJB12 | chr10 | 74114523 | - | ENST00000355568 | NEK5 | chr13 | 52650279 | - | 1516 | 385 | 241 | 864 | 207 |
| ENST00000444643 | DNAJB12 | chr10 | 74114523 | - | ENST00000355568 | NEK5 | chr13 | 52650279 | - | 1597 | 466 | 322 | 945 | 207 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000394903 | ENST00000355568 | DNAJB12 | chr10 | 74114523 | - | NEK5 | chr13 | 52650279 | - | 0.001476182 | 0.9985239 |
| ENST00000338820 | ENST00000355568 | DNAJB12 | chr10 | 74114523 | - | NEK5 | chr13 | 52650279 | - | 0.001476182 | 0.9985239 |
| ENST00000444643 | ENST00000355568 | DNAJB12 | chr10 | 74114523 | - | NEK5 | chr13 | 52650279 | - | 0.00126943 | 0.9987306 |
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Fusion Genomic Features for DNAJB12-NEK5 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for DNAJB12-NEK5 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:74114523/chr13:52650279) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DNAJB12 | NEK5 |
| FUNCTION: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:21150129, PubMed:21148293). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). {ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744). {ECO:0000269|PubMed:21673190, ECO:0000269|PubMed:24675744}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DNAJB12 | chr10:74114523 | chr13:52650279 | ENST00000444643 | - | 1 | 9 | 112_176 | 44 | 807.6666666666666 | Domain | J |
| Hgene | DNAJB12 | chr10:74114523 | chr13:52650279 | ENST00000444643 | - | 1 | 9 | 1_243 | 44 | 807.6666666666666 | Topological domain | Cytoplasmic |
| Hgene | DNAJB12 | chr10:74114523 | chr13:52650279 | ENST00000444643 | - | 1 | 9 | 265_375 | 44 | 807.6666666666666 | Topological domain | Lumenal |
| Hgene | DNAJB12 | chr10:74114523 | chr13:52650279 | ENST00000444643 | - | 1 | 9 | 244_264 | 44 | 807.6666666666666 | Transmembrane | Helical |
| Tgene | NEK5 | chr10:74114523 | chr13:52650279 | ENST00000355568 | 17 | 22 | 4_259 | 549 | 709.0 | Domain | Protein kinase | |
| Tgene | NEK5 | chr10:74114523 | chr13:52650279 | ENST00000355568 | 17 | 22 | 10_18 | 549 | 709.0 | Nucleotide binding | ATP |
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Fusion Gene Sequence for DNAJB12-NEK5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >23407_23407_1_DNAJB12-NEK5_DNAJB12_chr10_74114523_ENST00000338820_NEK5_chr13_52650279_ENST00000355568_length(transcript)=1516nt_BP=385nt GTTGGCGCATACTCAACTCTAAGACCTCCGGAACATGGAATCTGGGCGTGCACCATTATTGACACCTACACCAGCCGTCCCTTTCTTAGA AGACATACGGTAGCACTTCCACCCTCGCTCAAAACTCGGGAAAGGAGGGGCGGAGGGTGGATGTCATCACTCCGCGCCCGGCTGCCCGCG ACGCGCCGGCGGGTGGCGCAGCCCTTCGCTCGCCCGGCCTCCCCCTCCCTGGTTCCGCGTTCTGGTTCCGCCATGGAATCCAACAAGGAT GAAGCTGAGCGCTGTATCAGCATCGCCCTCAAGGCCATCCAGAGCAACCAGCCCGACCGGGCGCTCCGCTTCCTGGAGAAGGCACAGCGG CTGTATCCGACGCCGCGAGTTCGCGGACATTGAAAAAGACTTGAAACAAATGAGGCTTCAGAACACAAAGGAAAGTAAAAATCCAGAACA GAAATATAAAGCTAAGAAGGGGGTAAAATTTGAAATTAATTTAGACAAATGTATTTCTGATGAAAACATCCTCCAAGAGGAAGAGGCAAT GGATATACCAAATGAAACTTTGACCTTTGAGGATGGCATGAAGTTTAAGGAATATGAATGTGTAAAGGAGCATGGAGATTATACAGACAA AGCATTTGAAAAACTTCACTGCCCAGAAGCAGGGTTTTCCACGCAGACTGTAGCTGCTGTGGGAAACAGGAGGCAGTGGGATGGAGGAGC GCCTCAGACTCTGCTGCAGATGATGGCAGTGGCCGACATCACCTCCACCTGCCCCACGGGGCCTGACAGTGAGTCTGTGCTTAGCGTCAG TCGTCAGGAAGGGAAGACCAAGGACCCGTACAGCCCAGTGCTCATCCTGATGTGATAGTCTACTTCTCACTATACACCCTATAGATCTTG TATCAGACACTTTCAAATATGTTGTTTTGATATCTCCCTATGCCTAAAGAGACTTGCCTGCTAATTATCCTGGACAAATGACCACTCTAG ACATGCACATATAAAGGAGGAAAAATCCAGGATGCCACCTTCCTCAGAGTGAGGGAAAATGCGTGAGGAAGGACAGCTGACTTGATTTAC CTTCCAAGGCCAGCTCAACAACTTTTTTTGCGATTTCATAGGGTCATTTTTTTTTTTTTAATTTTTATTTTTTATTGATCATTCTTGGGT GTTTCTCGCAGAGGGGGATTTGGCAGGGTCATAGGACAATAGTGGAGGGAAGGTCAGCAGATAAACAAGTGAACAAAGGTCTCTGGTTTT TCTAGGCAGAGGACCCTGTGGCCTTCCGCAGTGTTTGTGTCCCTGGGTACTTGAGATTAGGGAGTGGTGATGATTCTTAACGAGCATGCT GCCTTCAAGCATCTGTTTAACAAAGCACATCTTGCACTGCCCTTAATCCATTCATCTCTGAGTGGACACAGCACATGTTTCAGAGAGCAC >23407_23407_1_DNAJB12-NEK5_DNAJB12_chr10_74114523_ENST00000338820_NEK5_chr13_52650279_ENST00000355568_length(amino acids)=207AA_BP=46 MVPPWNPTRMKLSAVSASPSRPSRATSPTGRSASWRRHSGCIRRREFADIEKDLKQMRLQNTKESKNPEQKYKAKKGVKFEINLDKCISD ENILQEEEAMDIPNETLTFEDGMKFKEYECVKEHGDYTDKAFEKLHCPEAGFSTQTVAAVGNRRQWDGGAPQTLLQMMAVADITSTCPTG -------------------------------------------------------------- >23407_23407_2_DNAJB12-NEK5_DNAJB12_chr10_74114523_ENST00000394903_NEK5_chr13_52650279_ENST00000355568_length(transcript)=1516nt_BP=385nt GTTGGCGCATACTCAACTCTAAGACCTCCGGAACATGGAATCTGGGCGTGCACCATTATTGACACCTACACCAGCCGTCCCTTTCTTAGA AGACATACGGTAGCACTTCCACCCTCGCTCAAAACTCGGGAAAGGAGGGGCGGAGGGTGGATGTCATCACTCCGCGCCCGGCTGCCCGCG ACGCGCCGGCGGGTGGCGCAGCCCTTCGCTCGCCCGGCCTCCCCCTCCCTGGTTCCGCGTTCTGGTTCCGCCATGGAATCCAACAAGGAT GAAGCTGAGCGCTGTATCAGCATCGCCCTCAAGGCCATCCAGAGCAACCAGCCCGACCGGGCGCTCCGCTTCCTGGAGAAGGCACAGCGG CTGTATCCGACGCCGCGAGTTCGCGGACATTGAAAAAGACTTGAAACAAATGAGGCTTCAGAACACAAAGGAAAGTAAAAATCCAGAACA GAAATATAAAGCTAAGAAGGGGGTAAAATTTGAAATTAATTTAGACAAATGTATTTCTGATGAAAACATCCTCCAAGAGGAAGAGGCAAT GGATATACCAAATGAAACTTTGACCTTTGAGGATGGCATGAAGTTTAAGGAATATGAATGTGTAAAGGAGCATGGAGATTATACAGACAA AGCATTTGAAAAACTTCACTGCCCAGAAGCAGGGTTTTCCACGCAGACTGTAGCTGCTGTGGGAAACAGGAGGCAGTGGGATGGAGGAGC GCCTCAGACTCTGCTGCAGATGATGGCAGTGGCCGACATCACCTCCACCTGCCCCACGGGGCCTGACAGTGAGTCTGTGCTTAGCGTCAG TCGTCAGGAAGGGAAGACCAAGGACCCGTACAGCCCAGTGCTCATCCTGATGTGATAGTCTACTTCTCACTATACACCCTATAGATCTTG TATCAGACACTTTCAAATATGTTGTTTTGATATCTCCCTATGCCTAAAGAGACTTGCCTGCTAATTATCCTGGACAAATGACCACTCTAG ACATGCACATATAAAGGAGGAAAAATCCAGGATGCCACCTTCCTCAGAGTGAGGGAAAATGCGTGAGGAAGGACAGCTGACTTGATTTAC CTTCCAAGGCCAGCTCAACAACTTTTTTTGCGATTTCATAGGGTCATTTTTTTTTTTTTAATTTTTATTTTTTATTGATCATTCTTGGGT GTTTCTCGCAGAGGGGGATTTGGCAGGGTCATAGGACAATAGTGGAGGGAAGGTCAGCAGATAAACAAGTGAACAAAGGTCTCTGGTTTT TCTAGGCAGAGGACCCTGTGGCCTTCCGCAGTGTTTGTGTCCCTGGGTACTTGAGATTAGGGAGTGGTGATGATTCTTAACGAGCATGCT GCCTTCAAGCATCTGTTTAACAAAGCACATCTTGCACTGCCCTTAATCCATTCATCTCTGAGTGGACACAGCACATGTTTCAGAGAGCAC >23407_23407_2_DNAJB12-NEK5_DNAJB12_chr10_74114523_ENST00000394903_NEK5_chr13_52650279_ENST00000355568_length(amino acids)=207AA_BP=46 MVPPWNPTRMKLSAVSASPSRPSRATSPTGRSASWRRHSGCIRRREFADIEKDLKQMRLQNTKESKNPEQKYKAKKGVKFEINLDKCISD ENILQEEEAMDIPNETLTFEDGMKFKEYECVKEHGDYTDKAFEKLHCPEAGFSTQTVAAVGNRRQWDGGAPQTLLQMMAVADITSTCPTG -------------------------------------------------------------- >23407_23407_3_DNAJB12-NEK5_DNAJB12_chr10_74114523_ENST00000444643_NEK5_chr13_52650279_ENST00000355568_length(transcript)=1597nt_BP=466nt ACTCCGAAGGCCCCAGTCTCATCCCGACGGCTACCACGTGACCTTCCTGAGCTTGGGTTTCCTCCTCCGGAAGATTAGAGGGTTGGCGCA TACTCAACTCTAAGACCTCCGGAACATGGAATCTGGGCGTGCACCATTATTGACACCTACACCAGCCGTCCCTTTCTTAGAAGACATACG GTAGCACTTCCACCCTCGCTCAAAACTCGGGAAAGGAGGGGCGGAGGGTGGATGTCATCACTCCGCGCCCGGCTGCCCGCGACGCGCCGG CGGGTGGCGCAGCCCTTCGCTCGCCCGGCCTCCCCCTCCCTGGTTCCGCGTTCTGGTTCCGCCATGGAATCCAACAAGGATGAAGCTGAG CGCTGTATCAGCATCGCCCTCAAGGCCATCCAGAGCAACCAGCCCGACCGGGCGCTCCGCTTCCTGGAGAAGGCACAGCGGCTGTATCCG ACGCCGCGAGTTCGCGGACATTGAAAAAGACTTGAAACAAATGAGGCTTCAGAACACAAAGGAAAGTAAAAATCCAGAACAGAAATATAA AGCTAAGAAGGGGGTAAAATTTGAAATTAATTTAGACAAATGTATTTCTGATGAAAACATCCTCCAAGAGGAAGAGGCAATGGATATACC AAATGAAACTTTGACCTTTGAGGATGGCATGAAGTTTAAGGAATATGAATGTGTAAAGGAGCATGGAGATTATACAGACAAAGCATTTGA AAAACTTCACTGCCCAGAAGCAGGGTTTTCCACGCAGACTGTAGCTGCTGTGGGAAACAGGAGGCAGTGGGATGGAGGAGCGCCTCAGAC TCTGCTGCAGATGATGGCAGTGGCCGACATCACCTCCACCTGCCCCACGGGGCCTGACAGTGAGTCTGTGCTTAGCGTCAGTCGTCAGGA AGGGAAGACCAAGGACCCGTACAGCCCAGTGCTCATCCTGATGTGATAGTCTACTTCTCACTATACACCCTATAGATCTTGTATCAGACA CTTTCAAATATGTTGTTTTGATATCTCCCTATGCCTAAAGAGACTTGCCTGCTAATTATCCTGGACAAATGACCACTCTAGACATGCACA TATAAAGGAGGAAAAATCCAGGATGCCACCTTCCTCAGAGTGAGGGAAAATGCGTGAGGAAGGACAGCTGACTTGATTTACCTTCCAAGG CCAGCTCAACAACTTTTTTTGCGATTTCATAGGGTCATTTTTTTTTTTTTAATTTTTATTTTTTATTGATCATTCTTGGGTGTTTCTCGC AGAGGGGGATTTGGCAGGGTCATAGGACAATAGTGGAGGGAAGGTCAGCAGATAAACAAGTGAACAAAGGTCTCTGGTTTTTCTAGGCAG AGGACCCTGTGGCCTTCCGCAGTGTTTGTGTCCCTGGGTACTTGAGATTAGGGAGTGGTGATGATTCTTAACGAGCATGCTGCCTTCAAG CATCTGTTTAACAAAGCACATCTTGCACTGCCCTTAATCCATTCATCTCTGAGTGGACACAGCACATGTTTCAGAGAGCACAGGGTTGGG >23407_23407_3_DNAJB12-NEK5_DNAJB12_chr10_74114523_ENST00000444643_NEK5_chr13_52650279_ENST00000355568_length(amino acids)=207AA_BP=46 MVPPWNPTRMKLSAVSASPSRPSRATSPTGRSASWRRHSGCIRRREFADIEKDLKQMRLQNTKESKNPEQKYKAKKGVKFEINLDKCISD ENILQEEEAMDIPNETLTFEDGMKFKEYECVKEHGDYTDKAFEKLHCPEAGFSTQTVAAVGNRRQWDGGAPQTLLQMMAVADITSTCPTG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for DNAJB12-NEK5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DNAJB12-NEK5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | NEK5 | Q6P3R8 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for DNAJB12-NEK5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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