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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APTX-NSUN3 (FusionGDB2 ID:HG54840TG63899)

Fusion Gene Summary for APTX-NSUN3

check button Fusion gene summary
Fusion gene informationFusion gene name: APTX-NSUN3
Fusion gene ID: hg54840tg63899
HgeneTgene
Gene symbol

APTX

NSUN3

Gene ID

54840

63899

Gene nameaprataxinNOP2/Sun RNA methyltransferase 3
SynonymsAOA|AOA1|AXA1|EAOH|EOAHA|FHA-HITMST077|MSTP077
Cytomap('APTX')('NSUN3')

9p21.1

3q11.2

Type of geneprotein-codingprotein-coding
Descriptionaprataxinforkhead-associated domain histidine triad-like proteintRNA (cytosine(34)-C(5))-methyltransferase, mitochondrialNOL1/NOP2/Sun domain family member 3NOP2/Sun RNA methyltransferase family member 3putative methyltransferase NSUN3
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000309615, ENST00000379813, 
ENST00000379817, ENST00000379819, 
ENST00000379825, ENST00000397172, 
ENST00000436040, ENST00000463596, 
ENST00000468275, ENST00000473270, 
ENST00000476858, 
Fusion gene scores* DoF score10 X 9 X 6=5403 X 3 X 3=27
# samples 123
** MAII scorelog2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: APTX [Title/Abstract] AND NSUN3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPTX(32988081)-NSUN3(93802951), # samples:1
Anticipated loss of major functional domain due to fusion event.APTX-NSUN3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APTX-NSUN3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APTX-NSUN3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APTX-NSUN3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APTX-NSUN3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPTX

GO:0000012

single strand break repair

17519253

HgeneAPTX

GO:0042542

response to hydrogen peroxide

15044383

TgeneNSUN3

GO:0002127

tRNA wobble base cytosine methylation

27214402|27356879|27497299


check buttonFusion gene breakpoints across APTX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NSUN3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8058-01AAPTXchr9

32988081

-NSUN3chr3

93802951

+


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Fusion Gene ORF analysis for APTX-NSUN3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000309615ENST00000485793APTXchr9

32988081

-NSUN3chr3

93802951

+
5CDS-intronENST00000379813ENST00000485793APTXchr9

32988081

-NSUN3chr3

93802951

+
5CDS-intronENST00000379817ENST00000485793APTXchr9

32988081

-NSUN3chr3

93802951

+
5CDS-intronENST00000379819ENST00000485793APTXchr9

32988081

-NSUN3chr3

93802951

+
5CDS-intronENST00000379825ENST00000485793APTXchr9

32988081

-NSUN3chr3

93802951

+
5CDS-intronENST00000397172ENST00000485793APTXchr9

32988081

-NSUN3chr3

93802951

+
5CDS-intronENST00000436040ENST00000485793APTXchr9

32988081

-NSUN3chr3

93802951

+
5CDS-intronENST00000463596ENST00000485793APTXchr9

32988081

-NSUN3chr3

93802951

+
5CDS-intronENST00000468275ENST00000485793APTXchr9

32988081

-NSUN3chr3

93802951

+
Frame-shiftENST00000309615ENST00000314622APTXchr9

32988081

-NSUN3chr3

93802951

+
Frame-shiftENST00000379817ENST00000314622APTXchr9

32988081

-NSUN3chr3

93802951

+
Frame-shiftENST00000379819ENST00000314622APTXchr9

32988081

-NSUN3chr3

93802951

+
Frame-shiftENST00000379825ENST00000314622APTXchr9

32988081

-NSUN3chr3

93802951

+
Frame-shiftENST00000397172ENST00000314622APTXchr9

32988081

-NSUN3chr3

93802951

+
Frame-shiftENST00000436040ENST00000314622APTXchr9

32988081

-NSUN3chr3

93802951

+
Frame-shiftENST00000463596ENST00000314622APTXchr9

32988081

-NSUN3chr3

93802951

+
Frame-shiftENST00000468275ENST00000314622APTXchr9

32988081

-NSUN3chr3

93802951

+
In-frameENST00000379813ENST00000314622APTXchr9

32988081

-NSUN3chr3

93802951

+
intron-3CDSENST00000473270ENST00000314622APTXchr9

32988081

-NSUN3chr3

93802951

+
intron-3CDSENST00000476858ENST00000314622APTXchr9

32988081

-NSUN3chr3

93802951

+
intron-intronENST00000473270ENST00000485793APTXchr9

32988081

-NSUN3chr3

93802951

+
intron-intronENST00000476858ENST00000485793APTXchr9

32988081

-NSUN3chr3

93802951

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000379813APTXchr932988081-ENST00000314622NSUN3chr393802951+31902342741134286

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379813ENST00000314622APTXchr932988081-NSUN3chr393802951+0.073552040.9264479

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Fusion Genomic Features for APTX-NSUN3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
APTXchr932988080-NSUN3chr393802950+0.0003532260.9996468
APTXchr932988080-NSUN3chr393802950+0.0003532260.9996468

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for APTX-NSUN3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:32988081/chr3:93802951)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNSUN3chr9:32988081chr3:93802951ENST0000031462216139_14540341.0RegionS-adenosyl-L-methionine binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPTXchr9:32988081chr3:93802951ENST00000309615-38182_28774307.0DomainHIT
HgeneAPTXchr9:32988081chr3:93802951ENST00000309615-3838_8774307.0DomainNote=FHA-like
HgeneAPTXchr9:32988081chr3:93802951ENST00000379813-38182_28760343.0DomainHIT
HgeneAPTXchr9:32988081chr3:93802951ENST00000379813-3838_8760343.0DomainNote=FHA-like
HgeneAPTXchr9:32988081chr3:93802951ENST00000379817-27182_28761343.0DomainHIT
HgeneAPTXchr9:32988081chr3:93802951ENST00000379817-2738_8761343.0DomainNote=FHA-like
HgeneAPTXchr9:32988081chr3:93802951ENST00000379819-38182_28775357.0DomainHIT
HgeneAPTXchr9:32988081chr3:93802951ENST00000379819-3838_8775357.0DomainNote=FHA-like
HgeneAPTXchr9:32988081chr3:93802951ENST00000379825-38182_28775307.0DomainHIT
HgeneAPTXchr9:32988081chr3:93802951ENST00000379825-3838_8775307.0DomainNote=FHA-like
HgeneAPTXchr9:32988081chr3:93802951ENST00000397172-38182_28775285.0DomainHIT
HgeneAPTXchr9:32988081chr3:93802951ENST00000397172-3838_8775285.0DomainNote=FHA-like
HgeneAPTXchr9:32988081chr3:93802951ENST00000436040-26182_28760445.0DomainHIT
HgeneAPTXchr9:32988081chr3:93802951ENST00000436040-2638_8760445.0DomainNote=FHA-like
HgeneAPTXchr9:32988081chr3:93802951ENST00000463596-38182_28761343.0DomainHIT
HgeneAPTXchr9:32988081chr3:93802951ENST00000463596-3838_8761343.0DomainNote=FHA-like
HgeneAPTXchr9:32988081chr3:93802951ENST00000468275-38182_28761343.0DomainHIT
HgeneAPTXchr9:32988081chr3:93802951ENST00000468275-3838_8761343.0DomainNote=FHA-like
HgeneAPTXchr9:32988081chr3:93802951ENST00000476858-17182_2870303.0DomainHIT
HgeneAPTXchr9:32988081chr3:93802951ENST00000476858-1738_870303.0DomainNote=FHA-like
HgeneAPTXchr9:32988081chr3:93802951ENST00000309615-38126_13174307.0MotifNuclear localization signal
HgeneAPTXchr9:32988081chr3:93802951ENST00000309615-38272_27674307.0MotifHistidine triad motif
HgeneAPTXchr9:32988081chr3:93802951ENST00000379813-38126_13160343.0MotifNuclear localization signal
HgeneAPTXchr9:32988081chr3:93802951ENST00000379813-38272_27660343.0MotifHistidine triad motif
HgeneAPTXchr9:32988081chr3:93802951ENST00000379817-27126_13161343.0MotifNuclear localization signal
HgeneAPTXchr9:32988081chr3:93802951ENST00000379817-27272_27661343.0MotifHistidine triad motif
HgeneAPTXchr9:32988081chr3:93802951ENST00000379819-38126_13175357.0MotifNuclear localization signal
HgeneAPTXchr9:32988081chr3:93802951ENST00000379819-38272_27675357.0MotifHistidine triad motif
HgeneAPTXchr9:32988081chr3:93802951ENST00000379825-38126_13175307.0MotifNuclear localization signal
HgeneAPTXchr9:32988081chr3:93802951ENST00000379825-38272_27675307.0MotifHistidine triad motif
HgeneAPTXchr9:32988081chr3:93802951ENST00000397172-38126_13175285.0MotifNuclear localization signal
HgeneAPTXchr9:32988081chr3:93802951ENST00000397172-38272_27675285.0MotifHistidine triad motif
HgeneAPTXchr9:32988081chr3:93802951ENST00000436040-26126_13160445.0MotifNuclear localization signal
HgeneAPTXchr9:32988081chr3:93802951ENST00000436040-26272_27660445.0MotifHistidine triad motif
HgeneAPTXchr9:32988081chr3:93802951ENST00000463596-38126_13161343.0MotifNuclear localization signal
HgeneAPTXchr9:32988081chr3:93802951ENST00000463596-38272_27661343.0MotifHistidine triad motif
HgeneAPTXchr9:32988081chr3:93802951ENST00000468275-38126_13161343.0MotifNuclear localization signal
HgeneAPTXchr9:32988081chr3:93802951ENST00000468275-38272_27661343.0MotifHistidine triad motif
HgeneAPTXchr9:32988081chr3:93802951ENST00000476858-17126_1310303.0MotifNuclear localization signal
HgeneAPTXchr9:32988081chr3:93802951ENST00000476858-17272_2760303.0MotifHistidine triad motif
HgeneAPTXchr9:32988081chr3:93802951ENST00000309615-38331_35374307.0Zinc fingerC2H2-type
HgeneAPTXchr9:32988081chr3:93802951ENST00000379813-38331_35360343.0Zinc fingerC2H2-type
HgeneAPTXchr9:32988081chr3:93802951ENST00000379817-27331_35361343.0Zinc fingerC2H2-type
HgeneAPTXchr9:32988081chr3:93802951ENST00000379819-38331_35375357.0Zinc fingerC2H2-type
HgeneAPTXchr9:32988081chr3:93802951ENST00000379825-38331_35375307.0Zinc fingerC2H2-type
HgeneAPTXchr9:32988081chr3:93802951ENST00000397172-38331_35375285.0Zinc fingerC2H2-type
HgeneAPTXchr9:32988081chr3:93802951ENST00000436040-26331_35360445.0Zinc fingerC2H2-type
HgeneAPTXchr9:32988081chr3:93802951ENST00000463596-38331_35361343.0Zinc fingerC2H2-type
HgeneAPTXchr9:32988081chr3:93802951ENST00000468275-38331_35361343.0Zinc fingerC2H2-type
HgeneAPTXchr9:32988081chr3:93802951ENST00000476858-17331_3530303.0Zinc fingerC2H2-type


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Fusion Gene Sequence for APTX-NSUN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5723_5723_1_APTX-NSUN3_APTX_chr9_32988081_ENST00000379813_NSUN3_chr3_93802951_ENST00000314622_length(transcript)=3190nt_BP=234nt
GGTGAGGCACAGATGAGTAACGTGAATTTGTCCGTCTCCGACTTCTGGAGAGTGATGATGCGGGTGTGCTGGTTGGTGAGACAGGACAGC
CGGCACCAGCGAATCAGACTTCCACATTTGGAAGCAGTTGTGATTGGGCGTGGCCCAGAGACCAAGATCACTGATAAGAAATGTTCTCGA
CAGCAAGTACAGTTGAAAGCAGAGTGTAACAAGGGATATGTCAAGGTAAAGCAGGGAGATACTAACATCTCCATCATGCTGGCAATATGC
TGTCCTGCTTAACCGATTCAATTATCCTTTTGAACTGGAAAAGGATTTACATTTGAAGGGCTATCACACACTCTCTCAGGGATCTTTACC
CAACTATCCTAAATCAGTGAAGTGTTACCTTAGCAGAACTCCGGGCCGAATCCCTTCAGAAAGACACCAAATTGGAAACCTGAAAAAATA
TTATCTCCTAAATGCTGCTTCTCTTCTCCCAGTGTTGGCTCTGGAATTAAGGGATGGGGAGAAGGTTCTGGATCTCTGTGCTGCTCCTGG
AGGGAAATCAATAGCTCTGCTGCAGTGTGCTTGTCCAGGTTATCTTCATTGTAATGAATATGATAGTCTGAGATTGAGGTGGCTAAGGCA
GACGTTGGAATCTTTCATCCCACAGCCTTTGATAAATGTAATTAAAGTGTCTGAATTGGATGGCAGAAAAATGGGAGATGCCCAGCCTGA
AATGTTTGACAAGGTGTTAGTGGATGCTCCGTGTTCAAATGATCGAAGCTGGTTGTTTTCTTCTGACTCTCAGAAGGCATCCTGTAGGAT
AAGTCAAAGGAGGAATTTGCCTCTTCTACAGATAGAGCTGTTAAGGTCTGCAATTAAGGCCTTACGTCCTGGAGGGATACTTGTATACTC
TACATGCACGCTTTCCAAGGCAGAAAATCAAGATGTGATCAGTGAAATTTTAAACTCCCACGGTAACATCATGCCTATGGACATTAAAGG
AATAGCAAGGACTTGCTCCCACGACTTCACATTTGCTCCCACTGGCCAGGAATGTGGGCTCTTAGTGATTCCAGATAAGGGCAAAGCCTG
GGGCCCAATGTATGTAGCCAAATTGAAGAAATCATGGAGCACAGGAAAATGGTGACATGAATTTGTAAACTGTGTTTATGTGTTATTATA
TTTATATTTCTGAACTCAGTACATGTTAATATTTAAATAATTATGCAGTAACTTTCTCTGGGTCTGTTTGGAATCCTATTTAGTTAATAC
TTTAGCATCTTAGAATCTAGGCTTGAGAATTGTTCAGGTGTATTTTTTTCCTAGAAATATATCTGTAACAATGATTTAAGGTGGTGCAGA
TGGTGTTTGTTCTATATTATAAATCTGCTGTCTTTGCTTGGCATTTTATAGTTAAATTAATTAGAATATGTGGTTTTATGCATAACGTGT
TTAGTTCTGTATTCTTTCTATGATAGTGCTTTGAACCTTCAAAAATTCACATTTTCCAGCGCTCCGACCATTTTCCCGCTTATCAAATGT
ACAAATTTGTTCAAGGTTTTTTTTTCCCCCCAACTTTTGTAACTGATTGTCTCAGAACTGATTGGTATTCTGAGACTAACTTTTTAAGCA
GCACTATTTCTAGTTCTGGCAAAATAGTTTTTTTATTTGCAATGTTGTTTTCTGTTAAAGACTATATTATGTTTACTGCAAAGGTCAGTG
ACTCTACTGACACCAGCTTTATTTCCCCCACTTTTTTTGCATTCACAAATACAAATTGAAAGGGTAAATTATATTGAAAGGCCTTTAGAA
CAGCAGATTCACATGCACATGTTTGACTTTCGACATTCAGCTTATAGAATTATGGAGTCTATCCAGCAGGCTATAAAGCAAGTACTTGAG
ACAAAACCGGAATGATTAATAACTGCAATCACTGAACTATATTTGGAGAGTTTTGTTACATAATTGCAGTCATAATGAGCACTACAGAAT
CTGATTATCTTACATTCACAATCTGGAGGGGCTTTTTATTTCACTTTGTTATAAAATGTTCTCTGAGAATATGATGCCACATATTAATGC
ACAAGAGGGAGATGCCTAATGAGAGTGGACTGTGTGATTACCAGAACCCAGTGCCATTTACTAAGTGGCTCTCCATGTTTACATAAATCC
TGGGAATACTGTATACATTTCTTCTTATGTACTTAGGGTTTTAGCTTCAGTCAGCATCACACTTTTTCTCCAGAAATTACTTCACTTAGA
GTACAAACATATTTTTCCAACTATTAAGAAAAATTATGCAGCACATCTCAAAAAATAGCATCTCTTTGGAAAATAGCCTTTAAAAAAAAA
CAACTTTATCTGATTATAGAAATACAAAATTCTGCTAAAGCTGAATACTTTTGAATTGTTCATTATGTTCTGTGCCTTTAAACTAGAGAC
TATTTGCTTATTAATATTTTTTGTTTTGCAAGCATATGTAACCCGGTTTATATCATCAGGAAGTCTTAGGAAGAATTTTTTTTTCTGTAC
CTTCAGTCTGTTAATCATTTGTTTTCCTTTATGTCCAATTGATATGTTTAAAGTAAAGCTAAAGTCCAGGCACGGTGGCTTATGCCTGTA
ATCCCAGCACTTTGTCAGGCCGAGGCAGGGGGCATCTCCTGAGGTCAGAAGTTCGAGACTAGCCTGCCCAACATGGTAAAACCCCGACTC
TACTAAAAATGCAAAAAAATTAGACAGGCATGGTGGCTGGCACCAGCAATCCCAGCTACTTAGGAGGCTGAGGCAGGAGAATCACTTGAA
CCCAGGAGGCAGAGGTTGCAGTTAGCCAAGATCTCGCCATTGCACTCCAGCCTGGGCGACAAGAGTGAAACCCCGTAGCAAAAAAATAAT
AATAATAGTAATTAAATAAAAATAAAGTAACGCTAGAACTGTTGGACCAAATCAAGTATATGGGTAAATACAGAAGAATAATGATGGTGG
AAAAGATGTTTTCTTTTTTAAGTTATCATTATTAGTTTGTTTTTTTTATCTTCAGACACTATAGGTTTTAAAAATAGGTTTCTTTTATGT
AGGTTAATCACAGAGTAAATCTGCACACTGTACTTTGTTAAATGTCGGTATTTTCCCAGTATAATGCGATGAAGCTTAATCTGAATACTT

>5723_5723_1_APTX-NSUN3_APTX_chr9_32988081_ENST00000379813_NSUN3_chr3_93802951_ENST00000314622_length(amino acids)=286AA_BP=
MLNRFNYPFELEKDLHLKGYHTLSQGSLPNYPKSVKCYLSRTPGRIPSERHQIGNLKKYYLLNAASLLPVLALELRDGEKVLDLCAAPGG
KSIALLQCACPGYLHCNEYDSLRLRWLRQTLESFIPQPLINVIKVSELDGRKMGDAQPEMFDKVLVDAPCSNDRSWLFSSDSQKASCRIS
QRRNLPLLQIELLRSAIKALRPGGILVYSTCTLSKAENQDVISEILNSHGNIMPMDIKGIARTCSHDFTFAPTGQECGLLVIPDKGKAWG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for APTX-NSUN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAPTXchr9:32988081chr3:93802951ENST00000309615-38207_21174.0307.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000309615-38269_27074.0307.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000379813-38207_21160.0343.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000379813-38269_27060.0343.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000379817-27207_21161.333333333333336343.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000379817-27269_27061.333333333333336343.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000379819-38207_21175.33333333333333357.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000379819-38269_27075.33333333333333357.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000379825-38207_21175.33333333333333307.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000379825-38269_27075.33333333333333307.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000397172-38207_21175.33333333333333285.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000397172-38269_27075.33333333333333285.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000436040-26207_21160.0445.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000436040-26269_27060.0445.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000463596-38207_21161.333333333333336343.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000463596-38269_27061.333333333333336343.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000468275-38207_21161.333333333333336343.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000468275-38269_27061.333333333333336343.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000476858-17207_2110303.0DNA substrate
HgeneAPTXchr9:32988081chr3:93802951ENST00000476858-17269_2700303.0DNA substrate


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APTX-NSUN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APTX-NSUN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPTXC1859598ATAXIA, EARLY-ONSET, WITH OCULOMOTOR APRAXIA AND HYPOALBUMINEMIA11CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneAPTXC0013421Dystonia1GENOMICS_ENGLAND
HgeneAPTXC0598589Inherited neuropathies1GENOMICS_ENGLAND
HgeneAPTXC1853761SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 11GENOMICS_ENGLAND