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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGEF38-GSTCD (FusionGDB2 ID:HG54848TG79807)

Fusion Gene Summary for ARHGEF38-GSTCD

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF38-GSTCD
Fusion gene ID: hg54848tg79807
HgeneTgene
Gene symbol

ARHGEF38

GSTCD

Gene ID

54848

79807

Gene nameRho guanine nucleotide exchange factor 38glutathione S-transferase C-terminal domain containing
Synonyms--
Cytomap('ARHGEF38')('GSTCD')

4q24

4q24

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 38Rho guanine nucleotide exchange factor (GEF) 38glutathione S-transferase C-terminal domain-containing protein
Modification date2020031320200313
UniProtAcc

Q9NXL2

Q8NEC7

Ensembl transtripts involved in fusion geneENST00000508036, ENST00000420470, 
ENST00000265154, 
Fusion gene scores* DoF score6 X 5 X 3=906 X 6 X 4=144
# samples 69
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/144*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGEF38 [Title/Abstract] AND GSTCD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF38(106575326)-GSTCD(106647735), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-G9-7525ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+


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Fusion Gene ORF analysis for ARHGEF38-GSTCD

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000508036ENST00000360505ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
3UTR-3UTRENST00000508036ENST00000394728ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
3UTR-3UTRENST00000508036ENST00000394730ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
3UTR-3UTRENST00000508036ENST00000507281ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
3UTR-3UTRENST00000508036ENST00000515255ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
3UTR-3UTRENST00000508036ENST00000515279ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
5CDS-3UTRENST00000420470ENST00000360505ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
5CDS-3UTRENST00000420470ENST00000394728ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
5CDS-3UTRENST00000420470ENST00000394730ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
5CDS-3UTRENST00000420470ENST00000507281ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
5CDS-3UTRENST00000420470ENST00000515255ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
5CDS-3UTRENST00000420470ENST00000515279ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
intron-3UTRENST00000265154ENST00000360505ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
intron-3UTRENST00000265154ENST00000394728ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
intron-3UTRENST00000265154ENST00000394730ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
intron-3UTRENST00000265154ENST00000507281ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
intron-3UTRENST00000265154ENST00000515255ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+
intron-3UTRENST00000265154ENST00000515279ARHGEF38chr4

106575326

+GSTCDchr4

106647735

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARHGEF38-GSTCD


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGEF38chr4106575326+GSTCDchr4106647735+0.99992427.58E-05
ARHGEF38chr4106575326+GSTCDchr4106647735+0.99992427.58E-05


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGEF38-GSTCD


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:106575326/:106647735)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGEF38

Q9NXL2

GSTCD

Q8NEC7

FUNCTION: May act as a guanine-nucleotide releasing factor. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARHGEF38-GSTCD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARHGEF38-GSTCD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGEF38-GSTCD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGEF38-GSTCD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human