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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:BCOR-L3MBTL2 (FusionGDB2 ID:HG54880TG83746)

Fusion Gene Summary for BCOR-L3MBTL2

check button Fusion gene summary
Fusion gene informationFusion gene name: BCOR-L3MBTL2
Fusion gene ID: hg54880tg83746
HgeneTgene
Gene symbol

BCOR

L3MBTL2

Gene ID

54880

83746

Gene nameBCL6 corepressorL3MBTL histone methyl-lysine binding protein 2
SynonymsANOP2|MAA2|MCOPS2H-l(3)mbt-l|L3MBT
Cytomap('BCOR')('L3MBTL2')

Xp11.4

22q13.2

Type of geneprotein-codingprotein-coding
DescriptionBCL-6 corepressorBCL-6 coreceptorBCL-6 interacting corepressorBCL6 interacting corepressorlethal(3)malignant brain tumor-like protein 2H-l(3)mbt-like protein 2L(3)mbt-like protein 2L3MBTL2, polycomb repressive complex 1 subunitl(3)mbt-like 2
Modification date2020032820200313
UniProtAcc

Q6W2J9

Q969R5

Ensembl transtripts involved in fusion geneENST00000342274, ENST00000378444, 
ENST00000378455, ENST00000397354, 
ENST00000378463, 
Fusion gene scores* DoF score11 X 15 X 7=11553 X 8 X 4=96
# samples 127
** MAII scorelog2(12/1155*10)=-3.2667865406949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BCOR [Title/Abstract] AND L3MBTL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBCOR(39931602)-L3MBTL2(41605700), # samples:3
Anticipated loss of major functional domain due to fusion event.BCOR-L3MBTL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BCOR-L3MBTL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BCOR-L3MBTL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BCOR-L3MBTL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BCOR-L3MBTL2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
BCOR-L3MBTL2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
BCOR-L3MBTL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BCOR-L3MBTL2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
BCOR-L3MBTL2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBCOR

GO:0035518

histone H2A monoubiquitination

16943429

HgeneBCOR

GO:0045892

negative regulation of transcription, DNA-templated

10898795


check buttonFusion gene breakpoints across BCOR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across L3MBTL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-6404-01ABCORchrX

39931601

-L3MBTL2chr22

41605699

+
ChimerDB4LGGTCGA-DU-6404-01ABCORchrX

39931602

-L3MBTL2chr22

41601255

+
ChimerDB4LGGTCGA-DU-6404-01ABCORchrX

39931602

-L3MBTL2chr22

41605700

+
ChimerDB4LGGTCGA-DU-6404-02BBCORchrX

39931602

-L3MBTL2chr22

41605700

+
ChimerDB4LGGTCGA-DU-6404BCORchrX

39931602

-L3MBTL2chr22

41601255

+
ChimerDB4LGGTCGA-DU-6404BCORchrX

39931602

-L3MBTL2chr22

41605700

+


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Fusion Gene ORF analysis for BCOR-L3MBTL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000342274ENST00000489136BCORchrX

39931601

-L3MBTL2chr22

41605699

+
5CDS-3UTRENST00000342274ENST00000489136BCORchrX

39931602

-L3MBTL2chr22

41605700

+
5CDS-3UTRENST00000378444ENST00000489136BCORchrX

39931601

-L3MBTL2chr22

41605699

+
5CDS-3UTRENST00000378444ENST00000489136BCORchrX

39931602

-L3MBTL2chr22

41605700

+
5CDS-3UTRENST00000378455ENST00000489136BCORchrX

39931601

-L3MBTL2chr22

41605699

+
5CDS-3UTRENST00000378455ENST00000489136BCORchrX

39931602

-L3MBTL2chr22

41605700

+
5CDS-3UTRENST00000397354ENST00000489136BCORchrX

39931601

-L3MBTL2chr22

41605699

+
5CDS-3UTRENST00000397354ENST00000489136BCORchrX

39931602

-L3MBTL2chr22

41605700

+
5CDS-5UTRENST00000342274ENST00000216237BCORchrX

39931602

-L3MBTL2chr22

41601255

+
5CDS-5UTRENST00000378444ENST00000216237BCORchrX

39931602

-L3MBTL2chr22

41601255

+
5CDS-5UTRENST00000378455ENST00000216237BCORchrX

39931602

-L3MBTL2chr22

41601255

+
5CDS-5UTRENST00000397354ENST00000216237BCORchrX

39931602

-L3MBTL2chr22

41601255

+
5CDS-intronENST00000342274ENST00000489136BCORchrX

39931602

-L3MBTL2chr22

41601255

+
5CDS-intronENST00000378444ENST00000489136BCORchrX

39931602

-L3MBTL2chr22

41601255

+
5CDS-intronENST00000378455ENST00000489136BCORchrX

39931602

-L3MBTL2chr22

41601255

+
5CDS-intronENST00000397354ENST00000489136BCORchrX

39931602

-L3MBTL2chr22

41601255

+
Frame-shiftENST00000342274ENST00000216237BCORchrX

39931601

-L3MBTL2chr22

41605699

+
Frame-shiftENST00000342274ENST00000216237BCORchrX

39931602

-L3MBTL2chr22

41605700

+
Frame-shiftENST00000378455ENST00000216237BCORchrX

39931601

-L3MBTL2chr22

41605699

+
Frame-shiftENST00000378455ENST00000216237BCORchrX

39931602

-L3MBTL2chr22

41605700

+
In-frameENST00000378444ENST00000216237BCORchrX

39931601

-L3MBTL2chr22

41605699

+
In-frameENST00000378444ENST00000216237BCORchrX

39931602

-L3MBTL2chr22

41605700

+
In-frameENST00000397354ENST00000216237BCORchrX

39931601

-L3MBTL2chr22

41605699

+
In-frameENST00000397354ENST00000216237BCORchrX

39931602

-L3MBTL2chr22

41605700

+
intron-3CDSENST00000378463ENST00000216237BCORchrX

39931601

-L3MBTL2chr22

41605699

+
intron-3CDSENST00000378463ENST00000216237BCORchrX

39931602

-L3MBTL2chr22

41605700

+
intron-3UTRENST00000378463ENST00000489136BCORchrX

39931601

-L3MBTL2chr22

41605699

+
intron-3UTRENST00000378463ENST00000489136BCORchrX

39931602

-L3MBTL2chr22

41605700

+
intron-5UTRENST00000378463ENST00000216237BCORchrX

39931602

-L3MBTL2chr22

41601255

+
intron-intronENST00000378463ENST00000489136BCORchrX

39931602

-L3MBTL2chr22

41601255

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397354BCORchrX39931602-ENST00000216237L3MBTL2chr2241605700+6340322622953191696
ENST00000378444BCORchrX39931602-ENST00000216237L3MBTL2chr2241605700+6340322622953191696
ENST00000397354BCORchrX39931601-ENST00000216237L3MBTL2chr2241605699+6340322622953191696
ENST00000378444BCORchrX39931601-ENST00000216237L3MBTL2chr2241605699+6340322622953191696

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397354ENST00000216237BCORchrX39931602-L3MBTL2chr2241605700+0.0008087880.9991912
ENST00000378444ENST00000216237BCORchrX39931602-L3MBTL2chr2241605700+0.0008087880.9991912
ENST00000397354ENST00000216237BCORchrX39931601-L3MBTL2chr2241605699+0.0008087880.9991912
ENST00000378444ENST00000216237BCORchrX39931601-L3MBTL2chr2241605699+0.0008087880.9991912

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Fusion Genomic Features for BCOR-L3MBTL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BCORchrX39931601-L3MBTL2chr2241605699+1.17E-081
BCORchrX39931601-L3MBTL2chr2241605699+1.17E-081
BCORchrX39931601-L3MBTL2chr2241605699+1.17E-081
BCORchrX39931601-L3MBTL2chr2241605699+1.17E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BCOR-L3MBTL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:39931602/chr22:41605700)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCOR

Q6W2J9

L3MBTL2

Q969R5

FUNCTION: Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}.FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. {ECO:0000269|PubMed:19233876}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBCORchrX:39931601chr22:41605699ENST00000342274-415634_7119991722.0Compositional biasNote=Pro-rich
HgeneBCORchrX:39931601chr22:41605699ENST00000378444-415634_7119991756.0Compositional biasNote=Pro-rich
HgeneBCORchrX:39931601chr22:41605699ENST00000378455-414634_7119991704.0Compositional biasNote=Pro-rich
HgeneBCORchrX:39931601chr22:41605699ENST00000397354-415634_7119991722.0Compositional biasNote=Pro-rich
HgeneBCORchrX:39931602chr22:41605700ENST00000342274-415634_7119991722.0Compositional biasNote=Pro-rich
HgeneBCORchrX:39931602chr22:41605700ENST00000378444-415634_7119991756.0Compositional biasNote=Pro-rich
HgeneBCORchrX:39931602chr22:41605700ENST00000378455-414634_7119991704.0Compositional biasNote=Pro-rich
HgeneBCORchrX:39931602chr22:41605700ENST00000397354-415634_7119991722.0Compositional biasNote=Pro-rich
TgeneL3MBTL2chrX:39931601chr22:41605699ENST0000021623701717_208706.0Compositional biasNote=Poly-Glu
TgeneL3MBTL2chrX:39931601chr22:41605699ENST00000216237017620_6248706.0Compositional biasNote=Poly-Lys
TgeneL3MBTL2chrX:39931602chr22:41605700ENST0000021623701717_208706.0Compositional biasNote=Poly-Glu
TgeneL3MBTL2chrX:39931602chr22:41605700ENST00000216237017620_6248706.0Compositional biasNote=Poly-Lys
TgeneL3MBTL2chrX:39931601chr22:41605699ENST00000216237017179_2838706.0RepeatNote=MBT 1
TgeneL3MBTL2chrX:39931601chr22:41605699ENST00000216237017291_3918706.0RepeatNote=MBT 2
TgeneL3MBTL2chrX:39931601chr22:41605699ENST00000216237017397_5008706.0RepeatNote=MBT 3
TgeneL3MBTL2chrX:39931601chr22:41605699ENST00000216237017508_6048706.0RepeatNote=MBT 4
TgeneL3MBTL2chrX:39931602chr22:41605700ENST00000216237017179_2838706.0RepeatNote=MBT 1
TgeneL3MBTL2chrX:39931602chr22:41605700ENST00000216237017291_3918706.0RepeatNote=MBT 2
TgeneL3MBTL2chrX:39931602chr22:41605700ENST00000216237017397_5008706.0RepeatNote=MBT 3
TgeneL3MBTL2chrX:39931602chr22:41605700ENST00000216237017508_6048706.0RepeatNote=MBT 4
TgeneL3MBTL2chrX:39931601chr22:41605699ENST0000021623701781_1168706.0Zinc fingerFCS-type
TgeneL3MBTL2chrX:39931602chr22:41605700ENST0000021623701781_1168706.0Zinc fingerFCS-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBCORchrX:39931601chr22:41605699ENST00000342274-4151625_16319991722.0Compositional biasNote=Poly-Asp
HgeneBCORchrX:39931601chr22:41605699ENST00000378444-4151625_16319991756.0Compositional biasNote=Poly-Asp
HgeneBCORchrX:39931601chr22:41605699ENST00000378455-4141625_16319991704.0Compositional biasNote=Poly-Asp
HgeneBCORchrX:39931601chr22:41605699ENST00000397354-4151625_16319991722.0Compositional biasNote=Poly-Asp
HgeneBCORchrX:39931602chr22:41605700ENST00000342274-4151625_16319991722.0Compositional biasNote=Poly-Asp
HgeneBCORchrX:39931602chr22:41605700ENST00000378444-4151625_16319991756.0Compositional biasNote=Poly-Asp
HgeneBCORchrX:39931602chr22:41605700ENST00000378455-4141625_16319991704.0Compositional biasNote=Poly-Asp
HgeneBCORchrX:39931602chr22:41605700ENST00000397354-4151625_16319991722.0Compositional biasNote=Poly-Asp
HgeneBCORchrX:39931601chr22:41605699ENST00000342274-4151462_14959991722.0RepeatNote=ANK 1
HgeneBCORchrX:39931601chr22:41605699ENST00000342274-4151496_15259991722.0RepeatNote=ANK 2
HgeneBCORchrX:39931601chr22:41605699ENST00000342274-4151529_15589991722.0RepeatNote=ANK 3
HgeneBCORchrX:39931601chr22:41605699ENST00000378444-4151462_14959991756.0RepeatNote=ANK 1
HgeneBCORchrX:39931601chr22:41605699ENST00000378444-4151496_15259991756.0RepeatNote=ANK 2
HgeneBCORchrX:39931601chr22:41605699ENST00000378444-4151529_15589991756.0RepeatNote=ANK 3
HgeneBCORchrX:39931601chr22:41605699ENST00000378455-4141462_14959991704.0RepeatNote=ANK 1
HgeneBCORchrX:39931601chr22:41605699ENST00000378455-4141496_15259991704.0RepeatNote=ANK 2
HgeneBCORchrX:39931601chr22:41605699ENST00000378455-4141529_15589991704.0RepeatNote=ANK 3
HgeneBCORchrX:39931601chr22:41605699ENST00000397354-4151462_14959991722.0RepeatNote=ANK 1
HgeneBCORchrX:39931601chr22:41605699ENST00000397354-4151496_15259991722.0RepeatNote=ANK 2
HgeneBCORchrX:39931601chr22:41605699ENST00000397354-4151529_15589991722.0RepeatNote=ANK 3
HgeneBCORchrX:39931602chr22:41605700ENST00000342274-4151462_14959991722.0RepeatNote=ANK 1
HgeneBCORchrX:39931602chr22:41605700ENST00000342274-4151496_15259991722.0RepeatNote=ANK 2
HgeneBCORchrX:39931602chr22:41605700ENST00000342274-4151529_15589991722.0RepeatNote=ANK 3
HgeneBCORchrX:39931602chr22:41605700ENST00000378444-4151462_14959991756.0RepeatNote=ANK 1
HgeneBCORchrX:39931602chr22:41605700ENST00000378444-4151496_15259991756.0RepeatNote=ANK 2
HgeneBCORchrX:39931602chr22:41605700ENST00000378444-4151529_15589991756.0RepeatNote=ANK 3
HgeneBCORchrX:39931602chr22:41605700ENST00000378455-4141462_14959991704.0RepeatNote=ANK 1
HgeneBCORchrX:39931602chr22:41605700ENST00000378455-4141496_15259991704.0RepeatNote=ANK 2
HgeneBCORchrX:39931602chr22:41605700ENST00000378455-4141529_15589991704.0RepeatNote=ANK 3
HgeneBCORchrX:39931602chr22:41605700ENST00000397354-4151462_14959991722.0RepeatNote=ANK 1
HgeneBCORchrX:39931602chr22:41605700ENST00000397354-4151496_15259991722.0RepeatNote=ANK 2
HgeneBCORchrX:39931602chr22:41605700ENST00000397354-4151529_15589991722.0RepeatNote=ANK 3


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Fusion Gene Sequence for BCOR-L3MBTL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9494_9494_1_BCOR-L3MBTL2_BCOR_chrX_39931601_ENST00000378444_L3MBTL2_chr22_41605699_ENST00000216237_length(transcript)=6340nt_BP=3226nt
GCTCGCCGCGCTTCTCCGGCCCGGCTCCTTCTCCGCTCGTTAACGTCGCCAACCCCCCCCACCCCTCATATCTCTCTCCACCCACCCAAC
CGCCCCCCGCTCCTTCTCGCCGCCTCGAGTCCGCTTGGGGGAAAACTTCAAAGAGCCGGATCGCAGGCTCCCTGCCTACTCCCCCACCGG
GGATTTCAGACTAGACGCTTGAAGCAAAGCTGCCATCCCAGAAGACGACATGCTCTCAGCAACCCCCCTGTATGGGAACGTTCACAGCTG
GATGAACAGCGAGAGGGTCCGCATGTGTGGGGCGAGCGAAGACAGGAAAATCCTTGTAAATGATGGTGACGCTTCAAAAGCCAGACTGGA
ACTGAGGGAAGAGAATCCCTTGAACCACAACGTGGTGGATGCGAGCACGGCCCATAGGATCGATGGCCTGGCAGCACTGAGCATGGACCG
CACTGGCCTGATCCGGGAAGGGCTGCGGGTCCCGGGAAACATCGTCTATTCTAGCTTGTGTGGACTGGGCTCAGAGAAAGGTCGGGAGGC
TGCCACAAGCACTCTAGGTGGCCTTGGGTTTTCTTCGGAAAGAAATCCAGAGATGCAGTTCAAACCGAATACACCCGAGACAGTGGAGGC
TTCTGCCGTCTCTGGAAAACCCCCAAATGGCTTCAGTGCTATATACAAAACACCGCCTGGAATACAAAAAAGTGCTGTAGCCACAGCAGA
AGCGCTGGGCTTGGACAGGCCTGCCAGCGACAAACAGAGCCCTCTCAACATCAATGGTGCTAGTTATCTGCGGCTGCCCTGGGTCAATCC
TTACATGGAGGGTGCCACGCCAGCCATCTACCCTTTCCTCGACTCGCCAAATAAGTATTCACTGAACATGTACAAGGCCTTGCTACCTCA
GCAGTCCTACAGCTTGGCCCAGCCGCTGTATTCTCCAGTCTGCACCAATGGGGAGCGCTTTCTCTACCTGCCGCCACCTCACTACGTCGG
TCCCCACATCCCATCGTCCTTGGCATCACCCATGAGGCTCTCGACACCTTCGGCCTCCCCAGCCATCCCGCCTCTCGTCCATTGCGCAGA
CAAAAGCCTCCCGTGGAAGATGGGCGTCAGCCCTGGGAATCCTGTTGATTCCCACGCCTATCCTCACATCCAGAACAGTAAGCAGCCCAG
GGTTCCCTCTGCCAAGGCGGTCACCAGTGGCCTGCCGGGGGACACAGCTCTCCTGTTGCCCCCCTCGCCTCGGCCGTCACCCCGAGTCCA
CCTTCCCACCCAGCCTGCTGCAGACACCTACTCGGAGTTCCACAAGCACTATGCCAGGATCTCCACCTCTCCTTCAGTTGCCCTGTCAAA
GCCATACATGACAGTTAGCAGCGAGTTCCCCGCGGCCAGGCTCTCCAATGGCAAGTATCCCAAGGCTCCGGAAGGGGGCGAAGGTGCCCA
GCCAGTGCCCGGGCATGCCCGGAAGACAGCGGTTCAAGACAGAAAAGATGGCAGCTCACCTCCTCTGTTGGAGAAGCAGACCGTTACCAA
AGACGTCACAGATAAGCCACTAGACTTGTCTTCTAAAGTGGTGGATGTAGATGCTTCCAAAGCTGACCACATGAAAAAGATGGCTCCCAC
GGTCCTGGTTCACAGCAGGGCTGGAAGTGGCTTAGTGCTCTCCGGAAGTGAGATTCCGAAAGAAACACTATCTCCTCCAGGAAATGGTTG
TGCTATCTATAGATCTGAAATCATCAGCACTGCTCCCTCATCCTGGGTGGTGCCCGGGCCAAGTCCTAACGAAGAGAACAATGGCAAAAG
CATGTCGCTGAAAAACAAGGCATTGGACTGGGCGATACCACAGCAGCGGAGTTCATCATGCCCGCGCATGGGCGGCACCGATGCTGTCAT
CACTAACGTTTCAGGGTCAGTGTCGAGTGCAGGCCGCCCAGCCTCCGCATCACCCGCCCCCAATGCCAATGCAGATGGCACCAAAACCAG
CAGGAGCTCTGTAGAAACCACACCATCCGTTATTCAGCACGTGGGCCAGCCCCCGGCCACTCCTGCCAAGCACAGTAGCAGCACCAGCAG
CAAGGGCGCCAAAGCCAGCAACCCAGAACCGAGTTTCAAAGCAAACGAGAACGGCCTTCCACCAAGCTCTATATTTCTGTCTCCAAATGA
GGCATTCAGGTCCCCACCAATTCCCTACCCCAGGAGTTACCTCCCTTACCCAGCCCCTGAGGGCATTGCTGTAAGTCCCCTCTCCTTACA
TGGCAAAGGACCTGTCTACCCTCACCCAGTTTTGTTACCCAATGGCAGTCTGTTTCCTGGGCACCTTGCCCCAAAGCCTGGGCTGCCCTA
TGGGCTTCCCACCGGCCGTCCAGAGTTTGTGACCTACCAAGATGCCCTGGGGTTGGGCATGGTGCATCCCATGTTGATACCACACACGCC
CATAGAGATTACTAAAGAGGAGAAACCAGAGAGGAGATCCCGGTCCCATGAGAGAGCCCGTTACGAGGACCCAACCCTCCGGAATCGGTT
TTCCGAGATTTTGGAAACTAGCAGCACCAAGTTACATCCAGATGTCCCCACCGACAAGAACCTAAAGCCGAACCCCAACTGGAATCAAGG
GAAGACTGTTGTCAAAAGCGACAAGCTTGTCTACGTAGACCTTCTCCGAGAAGAACCAGATGCTAAAACTGACACAAACGTGTCCAAACC
CAGCTTTGCAGCAGAGAGTGTTGGCCAGAGCGCTGAGCCCCCCAAGCCCTCAGTTGAGCCGGCCCTGCAGCAGCACCGTGATTTCATCGC
CCTGAGAGAGGAGTTGGGGCGCATCAGTGACTTCCACGAAACTTATACTTTCAAACAGCCAGTCTTCACCGTAAGCAAGGACAGTGTTCT
GGCAGGTACCAACAAAGAGAACCTAGGGTTGCCAGTCTCGACTCCATTCCTGGAGCCACCTCTGGGGAGCGATGGCCCTGCTGTAACTTT
TGGTAAAACCCAAGAGGATCCCAAACCATTTTGTGTGGGCAGTGCCCCACCAAGTGTGGATGTGACCCCCACCTATACCAAAGATGGAGC
TGATGAGGCTGAATCAAATGATGGCAAAGTTCTGAAACCGAAGCCATCTAAGCTGGCAAAGAGAATCGCCAACTCAGCGGGTTACGTGGG
TGACCGATTCAAATGTGTCACTACCGAACTGTATGCAGATTCCAGTCAGCTCAGCCGGGAGCAACGGGCATTGCAGGAGACCCCATCTTC
AGAACCAATGGAGGAAGAGGAAGATGACGACTTGGAGCTGTTTGGTGGCTATGATAGTTTCCGGAGTTATAACAGCAGTGTGGGCAGTGA
GAGCAGCTCCTATCTGGAGGAGTCAAGTGAAGCAGAAAATGAGGATCGGGAAGCAGGGGAACTGCCGACCTCCCCGCTGCATTTGCTCAG
CCCTGGGACTCCTCGCTCCTTGGATGGCAGTGGTTCTGAGCCAGCTGTCTGTGAGATGTGTGGTATCGTGGGTACAAGGGAAGCCTTCTT
CTCCAAGACCAAGAGGTTCTGCAGCGTCTCCTGCTCCAGGAGCTACTCCTCCAACTCCAAGAAAGCCAGTATCTTGGCTAGGTTACAGGG
AAAACCACCGACCAAAAAAGCCAAAGTCCTGCACAAGGCTGCCTGGTCTGCCAAAATTGGAGCCTTCCTCCACTCTCAAGGGACAGGACA
GCTGGCAGATGGGACACCAACAGGACAAGACGCTCTGGTCTTGGGCTTCGACTGGGGGAAGTTCCTGAAGGATCACAGTTACAAGGCTGC
TCCCGTCAGCTGTTTCAAGCACGTCCCACTCTATGACCAGTGGGAGGATGTGATGAAAGGGATGAAGGTGGAGGTGCTCAACAGTGATGC
TGTGCTCCCCAGCCGGGTGTACTGGATCGCCTCTGTCATCCAGACAGCAGGGTATCGGGTGCTGCTTCGGTATGAAGGCTTTGAAAATGA
CGCCAGCCATGACTTCTGGTGCAACCTGGGAACAGTGGATGTCCACCCCATTGGCTGGTGTGCCATCAACAGCAAGATCCTAGTGCCCCC
ACGGACCATCCATGCCAAGTTCACCGACTGGAAGGGCTACCTCATGAAACGGCTGGTGGGCTCCAGGACGCTTCCCGTGGATTTCCACAT
CAAGATGGTGGAGAGCATGAAGTACCCCTTTAGGCAGGGCATGCGGCTGGAAGTGGTGGACAAGTCCCAGGTGTCACGCACTCGCATGGC
TGTGGTGGACACAGTAATCGGGGGTCGCCTACGGCTCCTCTACGAGGATGGTGACAGTGACGACGACTTCTGGTGCCACATGTGGAGCCC
CCTGATCCACCCAGTGGGTTGGTCACGACGTGTGGGCCACGGCATCAAGATGTCAGAGAGGCGAAGTGACATGGCCCATCACCCCACCTT
CCGGAAGATCTACTGTGATGCCGTTCCTTACCTCTTCAAGAAGGTACGAGCAGTCTACACAGAAGGCGGTTGGTTTGAGGAAGGGATGAA
GCTGGAGGCCATTGACCCCCTGAATCTGGGCAACATCTGCGTGGCAACTGTCTGTAAGGTTCTCCTGGATGGATACCTGATGATCTGTGT
GGACGGGGGGCCCTCCACAGATGGCTTGGACTGGTTCTGCTACCATGCCTCTTCCCACGCCATCTTCCCGGCCACCTTCTGTCAGAAGAA
TGACATTGAGCTCACACCGCCAAAAGGTTATGAGGCACAGACTTTCAACTGGGAGAACTACTTGGAGAAGACCAAGTCGAAAGCCGCTCC
ATCGAGACTCTTTAACATGGATTGCCCAAACCATGGCTTCAAGGTGGGCATGAAGCTGGAGGCCGTGGACCTGATGGAGCCCCGGCTCAT
CTGTGTGGCCACGGTGAAACGAGTGGTGCATCGGCTCCTCAGCATCCACTTTGACGGCTGGGACAGCGAGTACGACCAGTGGGTGGACTG
CGAGTCCCCAGACATCTACCCCGTCGGCTGGTGTGAGCTCACCGGCTACCAGCTCCAGCCTCCTGTGGCCGCAGAACCGGCCACACCGCT
GAAGGCCAAAGAGGCCACAAAGAAGAAAAAGAAACAGTTTGGGAAGAAAAGGAAAAGAATCCCGCCCACTAAGACGCGACCCCTCAGACA
GGGGTCCAAGAAGCCCCTGCTGGAGGACGACCCTCAGGGTGCCAGGAAGATCTCGTCGGAGCCTGTTCCTGGCGAGATCATTGCTGTGCG
TGTGAAGGAAGAGCATCTAGACGTGGCCTCGCCCGACAAGGCTTCAAGTCCAGAGCTGCCTGTCTCCGTCGAGAACATCAAGCAGGAAAC
AGACGACTGAGCCTTCCTGCCTCCAGCCTGGCTTCTAGCTGGAAGCCAGCCCAGCGTTTCTCTACCACCACCACCATGCCTCCACCTGAC
TTTGGCTTGGAGACTGATCCTCTCTGTGTAAATTCTGCCCGGTGCTGTGAAGGCTGGACGGTGGAGGACCTGCTGGGGTCTCCTGGGACC
CGCCTGTTGCTTCTGCCCTCCCCTGTGGAAAGGTCTATATGACGGGCCGCCTGAGGCCCCAGAACTCGTCTGTGAACCACCTTTTCCAGC
CAGAGTTCCCAAAGCTGGAACGCTAGCTGCCTGCTCTTCCTTAAGATGGCCTCCCCCCGACCCGCCACGGCCCTCAGTTGCCAGGGATGG
GGCCACCACTGTCACACTGTGGAATACAAGACAGTGAACTCTGTCTGCCTGAACGAGCCATGTAAATTAAGTTCTAGAGCAGCTCTCTGA
GCAGGATAAGGTCCCCTGACAGTGAGTTGTGTGGTGGGGGCAGCCTCTGCCTCAAAAATTCACCAAGCAGAATGCCTCTCAGCCTCATGT
GTTGGTCCTCTGCTCCTCCTAGCTCCCCAGGGATGTTGGGGACCCAGCTTGTCTCGGCAGCTAAGAAGCAGTGACCAGGATGTGGATTTT
GGCGACCTGTGTGGTGGCCTTGAGCTGCTTTCTGTGTTTGTGAGGACTGACTCCCATTTCCTAAAGGAAATGCCCCCGGGGAGGACATTG
GGAGGAAGATGGCCTGAGTGTGCACTTTGGCTCTGCTACCTGCTCCTGAAGCCCCGCTAAAAATAATTCATCCAAGATTCCTTTGTAGTT
AAAGGGTCCAGTTCTGACTGGAGCCTCTAGAGAGCTGGGCTTGTATGTTCTTTTGGCCTTTTGTTCCTACCTAAATGAAGAAACCATGCC
TGGAGGGGCCGTGAACACAGAACCCTCAAGACAAGGATGACAGAGCTGGAGGACACATCTAGCTGCCATTGCAACCTCACTGGGCTCCCC

>9494_9494_1_BCOR-L3MBTL2_BCOR_chrX_39931601_ENST00000378444_L3MBTL2_chr22_41605699_ENST00000216237_length(amino acids)=1696AA_BP=999
MLSATPLYGNVHSWMNSERVRMCGASEDRKILVNDGDASKARLELREENPLNHNVVDASTAHRIDGLAALSMDRTGLIREGLRVPGNIVY
SSLCGLGSEKGREAATSTLGGLGFSSERNPEMQFKPNTPETVEASAVSGKPPNGFSAIYKTPPGIQKSAVATAEALGLDRPASDKQSPLN
INGASYLRLPWVNPYMEGATPAIYPFLDSPNKYSLNMYKALLPQQSYSLAQPLYSPVCTNGERFLYLPPPHYVGPHIPSSLASPMRLSTP
SASPAIPPLVHCADKSLPWKMGVSPGNPVDSHAYPHIQNSKQPRVPSAKAVTSGLPGDTALLLPPSPRPSPRVHLPTQPAADTYSEFHKH
YARISTSPSVALSKPYMTVSSEFPAARLSNGKYPKAPEGGEGAQPVPGHARKTAVQDRKDGSSPPLLEKQTVTKDVTDKPLDLSSKVVDV
DASKADHMKKMAPTVLVHSRAGSGLVLSGSEIPKETLSPPGNGCAIYRSEIISTAPSSWVVPGPSPNEENNGKSMSLKNKALDWAIPQQR
SSSCPRMGGTDAVITNVSGSVSSAGRPASASPAPNANADGTKTSRSSVETTPSVIQHVGQPPATPAKHSSSTSSKGAKASNPEPSFKANE
NGLPPSSIFLSPNEAFRSPPIPYPRSYLPYPAPEGIAVSPLSLHGKGPVYPHPVLLPNGSLFPGHLAPKPGLPYGLPTGRPEFVTYQDAL
GLGMVHPMLIPHTPIEITKEEKPERRSRSHERARYEDPTLRNRFSEILETSSTKLHPDVPTDKNLKPNPNWNQGKTVVKSDKLVYVDLLR
EEPDAKTDTNVSKPSFAAESVGQSAEPPKPSVEPALQQHRDFIALREELGRISDFHETYTFKQPVFTVSKDSVLAGTNKENLGLPVSTPF
LEPPLGSDGPAVTFGKTQEDPKPFCVGSAPPSVDVTPTYTKDGADEAESNDGKVLKPKPSKLAKRIANSAGYVGDRFKCVTTELYADSSQ
LSREQRALQETPSSEPMEEEEDDDLELFGGYDSFRSYNSSVGSESSSYLEESSEAENEDREAGELPTSPLHLLSPGTPRSLDGSGSEPAV
CEMCGIVGTREAFFSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTKKAKVLHKAAWSAKIGAFLHSQGTGQLADGTPTGQDALVLGF
DWGKFLKDHSYKAAPVSCFKHVPLYDQWEDVMKGMKVEVLNSDAVLPSRVYWIASVIQTAGYRVLLRYEGFENDASHDFWCNLGTVDVHP
IGWCAINSKILVPPRTIHAKFTDWKGYLMKRLVGSRTLPVDFHIKMVESMKYPFRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYED
GDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRSDMAHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGNICVAT
VCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATFCQKNDIELTPPKGYEAQTFNWENYLEKTKSKAAPSRLFNMDCPNHGFKVG
MKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPPVAAEPATPLKAKEATKKKKKQFGKK

--------------------------------------------------------------
>9494_9494_2_BCOR-L3MBTL2_BCOR_chrX_39931601_ENST00000397354_L3MBTL2_chr22_41605699_ENST00000216237_length(transcript)=6340nt_BP=3226nt
GCTCGCCGCGCTTCTCCGGCCCGGCTCCTTCTCCGCTCGTTAACGTCGCCAACCCCCCCCACCCCTCATATCTCTCTCCACCCACCCAAC
CGCCCCCCGCTCCTTCTCGCCGCCTCGAGTCCGCTTGGGGGAAAACTTCAAAGAGCCGGATCGCAGGCTCCCTGCCTACTCCCCCACCGG
GGATTTCAGACTAGACGCTTGAAGCAAAGCTGCCATCCCAGAAGACGACATGCTCTCAGCAACCCCCCTGTATGGGAACGTTCACAGCTG
GATGAACAGCGAGAGGGTCCGCATGTGTGGGGCGAGCGAAGACAGGAAAATCCTTGTAAATGATGGTGACGCTTCAAAAGCCAGACTGGA
ACTGAGGGAAGAGAATCCCTTGAACCACAACGTGGTGGATGCGAGCACGGCCCATAGGATCGATGGCCTGGCAGCACTGAGCATGGACCG
CACTGGCCTGATCCGGGAAGGGCTGCGGGTCCCGGGAAACATCGTCTATTCTAGCTTGTGTGGACTGGGCTCAGAGAAAGGTCGGGAGGC
TGCCACAAGCACTCTAGGTGGCCTTGGGTTTTCTTCGGAAAGAAATCCAGAGATGCAGTTCAAACCGAATACACCCGAGACAGTGGAGGC
TTCTGCCGTCTCTGGAAAACCCCCAAATGGCTTCAGTGCTATATACAAAACACCGCCTGGAATACAAAAAAGTGCTGTAGCCACAGCAGA
AGCGCTGGGCTTGGACAGGCCTGCCAGCGACAAACAGAGCCCTCTCAACATCAATGGTGCTAGTTATCTGCGGCTGCCCTGGGTCAATCC
TTACATGGAGGGTGCCACGCCAGCCATCTACCCTTTCCTCGACTCGCCAAATAAGTATTCACTGAACATGTACAAGGCCTTGCTACCTCA
GCAGTCCTACAGCTTGGCCCAGCCGCTGTATTCTCCAGTCTGCACCAATGGGGAGCGCTTTCTCTACCTGCCGCCACCTCACTACGTCGG
TCCCCACATCCCATCGTCCTTGGCATCACCCATGAGGCTCTCGACACCTTCGGCCTCCCCAGCCATCCCGCCTCTCGTCCATTGCGCAGA
CAAAAGCCTCCCGTGGAAGATGGGCGTCAGCCCTGGGAATCCTGTTGATTCCCACGCCTATCCTCACATCCAGAACAGTAAGCAGCCCAG
GGTTCCCTCTGCCAAGGCGGTCACCAGTGGCCTGCCGGGGGACACAGCTCTCCTGTTGCCCCCCTCGCCTCGGCCGTCACCCCGAGTCCA
CCTTCCCACCCAGCCTGCTGCAGACACCTACTCGGAGTTCCACAAGCACTATGCCAGGATCTCCACCTCTCCTTCAGTTGCCCTGTCAAA
GCCATACATGACAGTTAGCAGCGAGTTCCCCGCGGCCAGGCTCTCCAATGGCAAGTATCCCAAGGCTCCGGAAGGGGGCGAAGGTGCCCA
GCCAGTGCCCGGGCATGCCCGGAAGACAGCGGTTCAAGACAGAAAAGATGGCAGCTCACCTCCTCTGTTGGAGAAGCAGACCGTTACCAA
AGACGTCACAGATAAGCCACTAGACTTGTCTTCTAAAGTGGTGGATGTAGATGCTTCCAAAGCTGACCACATGAAAAAGATGGCTCCCAC
GGTCCTGGTTCACAGCAGGGCTGGAAGTGGCTTAGTGCTCTCCGGAAGTGAGATTCCGAAAGAAACACTATCTCCTCCAGGAAATGGTTG
TGCTATCTATAGATCTGAAATCATCAGCACTGCTCCCTCATCCTGGGTGGTGCCCGGGCCAAGTCCTAACGAAGAGAACAATGGCAAAAG
CATGTCGCTGAAAAACAAGGCATTGGACTGGGCGATACCACAGCAGCGGAGTTCATCATGCCCGCGCATGGGCGGCACCGATGCTGTCAT
CACTAACGTTTCAGGGTCAGTGTCGAGTGCAGGCCGCCCAGCCTCCGCATCACCCGCCCCCAATGCCAATGCAGATGGCACCAAAACCAG
CAGGAGCTCTGTAGAAACCACACCATCCGTTATTCAGCACGTGGGCCAGCCCCCGGCCACTCCTGCCAAGCACAGTAGCAGCACCAGCAG
CAAGGGCGCCAAAGCCAGCAACCCAGAACCGAGTTTCAAAGCAAACGAGAACGGCCTTCCACCAAGCTCTATATTTCTGTCTCCAAATGA
GGCATTCAGGTCCCCACCAATTCCCTACCCCAGGAGTTACCTCCCTTACCCAGCCCCTGAGGGCATTGCTGTAAGTCCCCTCTCCTTACA
TGGCAAAGGACCTGTCTACCCTCACCCAGTTTTGTTACCCAATGGCAGTCTGTTTCCTGGGCACCTTGCCCCAAAGCCTGGGCTGCCCTA
TGGGCTTCCCACCGGCCGTCCAGAGTTTGTGACCTACCAAGATGCCCTGGGGTTGGGCATGGTGCATCCCATGTTGATACCACACACGCC
CATAGAGATTACTAAAGAGGAGAAACCAGAGAGGAGATCCCGGTCCCATGAGAGAGCCCGTTACGAGGACCCAACCCTCCGGAATCGGTT
TTCCGAGATTTTGGAAACTAGCAGCACCAAGTTACATCCAGATGTCCCCACCGACAAGAACCTAAAGCCGAACCCCAACTGGAATCAAGG
GAAGACTGTTGTCAAAAGCGACAAGCTTGTCTACGTAGACCTTCTCCGAGAAGAACCAGATGCTAAAACTGACACAAACGTGTCCAAACC
CAGCTTTGCAGCAGAGAGTGTTGGCCAGAGCGCTGAGCCCCCCAAGCCCTCAGTTGAGCCGGCCCTGCAGCAGCACCGTGATTTCATCGC
CCTGAGAGAGGAGTTGGGGCGCATCAGTGACTTCCACGAAACTTATACTTTCAAACAGCCAGTCTTCACCGTAAGCAAGGACAGTGTTCT
GGCAGGTACCAACAAAGAGAACCTAGGGTTGCCAGTCTCGACTCCATTCCTGGAGCCACCTCTGGGGAGCGATGGCCCTGCTGTAACTTT
TGGTAAAACCCAAGAGGATCCCAAACCATTTTGTGTGGGCAGTGCCCCACCAAGTGTGGATGTGACCCCCACCTATACCAAAGATGGAGC
TGATGAGGCTGAATCAAATGATGGCAAAGTTCTGAAACCGAAGCCATCTAAGCTGGCAAAGAGAATCGCCAACTCAGCGGGTTACGTGGG
TGACCGATTCAAATGTGTCACTACCGAACTGTATGCAGATTCCAGTCAGCTCAGCCGGGAGCAACGGGCATTGCAGGAGACCCCATCTTC
AGAACCAATGGAGGAAGAGGAAGATGACGACTTGGAGCTGTTTGGTGGCTATGATAGTTTCCGGAGTTATAACAGCAGTGTGGGCAGTGA
GAGCAGCTCCTATCTGGAGGAGTCAAGTGAAGCAGAAAATGAGGATCGGGAAGCAGGGGAACTGCCGACCTCCCCGCTGCATTTGCTCAG
CCCTGGGACTCCTCGCTCCTTGGATGGCAGTGGTTCTGAGCCAGCTGTCTGTGAGATGTGTGGTATCGTGGGTACAAGGGAAGCCTTCTT
CTCCAAGACCAAGAGGTTCTGCAGCGTCTCCTGCTCCAGGAGCTACTCCTCCAACTCCAAGAAAGCCAGTATCTTGGCTAGGTTACAGGG
AAAACCACCGACCAAAAAAGCCAAAGTCCTGCACAAGGCTGCCTGGTCTGCCAAAATTGGAGCCTTCCTCCACTCTCAAGGGACAGGACA
GCTGGCAGATGGGACACCAACAGGACAAGACGCTCTGGTCTTGGGCTTCGACTGGGGGAAGTTCCTGAAGGATCACAGTTACAAGGCTGC
TCCCGTCAGCTGTTTCAAGCACGTCCCACTCTATGACCAGTGGGAGGATGTGATGAAAGGGATGAAGGTGGAGGTGCTCAACAGTGATGC
TGTGCTCCCCAGCCGGGTGTACTGGATCGCCTCTGTCATCCAGACAGCAGGGTATCGGGTGCTGCTTCGGTATGAAGGCTTTGAAAATGA
CGCCAGCCATGACTTCTGGTGCAACCTGGGAACAGTGGATGTCCACCCCATTGGCTGGTGTGCCATCAACAGCAAGATCCTAGTGCCCCC
ACGGACCATCCATGCCAAGTTCACCGACTGGAAGGGCTACCTCATGAAACGGCTGGTGGGCTCCAGGACGCTTCCCGTGGATTTCCACAT
CAAGATGGTGGAGAGCATGAAGTACCCCTTTAGGCAGGGCATGCGGCTGGAAGTGGTGGACAAGTCCCAGGTGTCACGCACTCGCATGGC
TGTGGTGGACACAGTAATCGGGGGTCGCCTACGGCTCCTCTACGAGGATGGTGACAGTGACGACGACTTCTGGTGCCACATGTGGAGCCC
CCTGATCCACCCAGTGGGTTGGTCACGACGTGTGGGCCACGGCATCAAGATGTCAGAGAGGCGAAGTGACATGGCCCATCACCCCACCTT
CCGGAAGATCTACTGTGATGCCGTTCCTTACCTCTTCAAGAAGGTACGAGCAGTCTACACAGAAGGCGGTTGGTTTGAGGAAGGGATGAA
GCTGGAGGCCATTGACCCCCTGAATCTGGGCAACATCTGCGTGGCAACTGTCTGTAAGGTTCTCCTGGATGGATACCTGATGATCTGTGT
GGACGGGGGGCCCTCCACAGATGGCTTGGACTGGTTCTGCTACCATGCCTCTTCCCACGCCATCTTCCCGGCCACCTTCTGTCAGAAGAA
TGACATTGAGCTCACACCGCCAAAAGGTTATGAGGCACAGACTTTCAACTGGGAGAACTACTTGGAGAAGACCAAGTCGAAAGCCGCTCC
ATCGAGACTCTTTAACATGGATTGCCCAAACCATGGCTTCAAGGTGGGCATGAAGCTGGAGGCCGTGGACCTGATGGAGCCCCGGCTCAT
CTGTGTGGCCACGGTGAAACGAGTGGTGCATCGGCTCCTCAGCATCCACTTTGACGGCTGGGACAGCGAGTACGACCAGTGGGTGGACTG
CGAGTCCCCAGACATCTACCCCGTCGGCTGGTGTGAGCTCACCGGCTACCAGCTCCAGCCTCCTGTGGCCGCAGAACCGGCCACACCGCT
GAAGGCCAAAGAGGCCACAAAGAAGAAAAAGAAACAGTTTGGGAAGAAAAGGAAAAGAATCCCGCCCACTAAGACGCGACCCCTCAGACA
GGGGTCCAAGAAGCCCCTGCTGGAGGACGACCCTCAGGGTGCCAGGAAGATCTCGTCGGAGCCTGTTCCTGGCGAGATCATTGCTGTGCG
TGTGAAGGAAGAGCATCTAGACGTGGCCTCGCCCGACAAGGCTTCAAGTCCAGAGCTGCCTGTCTCCGTCGAGAACATCAAGCAGGAAAC
AGACGACTGAGCCTTCCTGCCTCCAGCCTGGCTTCTAGCTGGAAGCCAGCCCAGCGTTTCTCTACCACCACCACCATGCCTCCACCTGAC
TTTGGCTTGGAGACTGATCCTCTCTGTGTAAATTCTGCCCGGTGCTGTGAAGGCTGGACGGTGGAGGACCTGCTGGGGTCTCCTGGGACC
CGCCTGTTGCTTCTGCCCTCCCCTGTGGAAAGGTCTATATGACGGGCCGCCTGAGGCCCCAGAACTCGTCTGTGAACCACCTTTTCCAGC
CAGAGTTCCCAAAGCTGGAACGCTAGCTGCCTGCTCTTCCTTAAGATGGCCTCCCCCCGACCCGCCACGGCCCTCAGTTGCCAGGGATGG
GGCCACCACTGTCACACTGTGGAATACAAGACAGTGAACTCTGTCTGCCTGAACGAGCCATGTAAATTAAGTTCTAGAGCAGCTCTCTGA
GCAGGATAAGGTCCCCTGACAGTGAGTTGTGTGGTGGGGGCAGCCTCTGCCTCAAAAATTCACCAAGCAGAATGCCTCTCAGCCTCATGT
GTTGGTCCTCTGCTCCTCCTAGCTCCCCAGGGATGTTGGGGACCCAGCTTGTCTCGGCAGCTAAGAAGCAGTGACCAGGATGTGGATTTT
GGCGACCTGTGTGGTGGCCTTGAGCTGCTTTCTGTGTTTGTGAGGACTGACTCCCATTTCCTAAAGGAAATGCCCCCGGGGAGGACATTG
GGAGGAAGATGGCCTGAGTGTGCACTTTGGCTCTGCTACCTGCTCCTGAAGCCCCGCTAAAAATAATTCATCCAAGATTCCTTTGTAGTT
AAAGGGTCCAGTTCTGACTGGAGCCTCTAGAGAGCTGGGCTTGTATGTTCTTTTGGCCTTTTGTTCCTACCTAAATGAAGAAACCATGCC
TGGAGGGGCCGTGAACACAGAACCCTCAAGACAAGGATGACAGAGCTGGAGGACACATCTAGCTGCCATTGCAACCTCACTGGGCTCCCC

>9494_9494_2_BCOR-L3MBTL2_BCOR_chrX_39931601_ENST00000397354_L3MBTL2_chr22_41605699_ENST00000216237_length(amino acids)=1696AA_BP=999
MLSATPLYGNVHSWMNSERVRMCGASEDRKILVNDGDASKARLELREENPLNHNVVDASTAHRIDGLAALSMDRTGLIREGLRVPGNIVY
SSLCGLGSEKGREAATSTLGGLGFSSERNPEMQFKPNTPETVEASAVSGKPPNGFSAIYKTPPGIQKSAVATAEALGLDRPASDKQSPLN
INGASYLRLPWVNPYMEGATPAIYPFLDSPNKYSLNMYKALLPQQSYSLAQPLYSPVCTNGERFLYLPPPHYVGPHIPSSLASPMRLSTP
SASPAIPPLVHCADKSLPWKMGVSPGNPVDSHAYPHIQNSKQPRVPSAKAVTSGLPGDTALLLPPSPRPSPRVHLPTQPAADTYSEFHKH
YARISTSPSVALSKPYMTVSSEFPAARLSNGKYPKAPEGGEGAQPVPGHARKTAVQDRKDGSSPPLLEKQTVTKDVTDKPLDLSSKVVDV
DASKADHMKKMAPTVLVHSRAGSGLVLSGSEIPKETLSPPGNGCAIYRSEIISTAPSSWVVPGPSPNEENNGKSMSLKNKALDWAIPQQR
SSSCPRMGGTDAVITNVSGSVSSAGRPASASPAPNANADGTKTSRSSVETTPSVIQHVGQPPATPAKHSSSTSSKGAKASNPEPSFKANE
NGLPPSSIFLSPNEAFRSPPIPYPRSYLPYPAPEGIAVSPLSLHGKGPVYPHPVLLPNGSLFPGHLAPKPGLPYGLPTGRPEFVTYQDAL
GLGMVHPMLIPHTPIEITKEEKPERRSRSHERARYEDPTLRNRFSEILETSSTKLHPDVPTDKNLKPNPNWNQGKTVVKSDKLVYVDLLR
EEPDAKTDTNVSKPSFAAESVGQSAEPPKPSVEPALQQHRDFIALREELGRISDFHETYTFKQPVFTVSKDSVLAGTNKENLGLPVSTPF
LEPPLGSDGPAVTFGKTQEDPKPFCVGSAPPSVDVTPTYTKDGADEAESNDGKVLKPKPSKLAKRIANSAGYVGDRFKCVTTELYADSSQ
LSREQRALQETPSSEPMEEEEDDDLELFGGYDSFRSYNSSVGSESSSYLEESSEAENEDREAGELPTSPLHLLSPGTPRSLDGSGSEPAV
CEMCGIVGTREAFFSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTKKAKVLHKAAWSAKIGAFLHSQGTGQLADGTPTGQDALVLGF
DWGKFLKDHSYKAAPVSCFKHVPLYDQWEDVMKGMKVEVLNSDAVLPSRVYWIASVIQTAGYRVLLRYEGFENDASHDFWCNLGTVDVHP
IGWCAINSKILVPPRTIHAKFTDWKGYLMKRLVGSRTLPVDFHIKMVESMKYPFRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYED
GDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRSDMAHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGNICVAT
VCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATFCQKNDIELTPPKGYEAQTFNWENYLEKTKSKAAPSRLFNMDCPNHGFKVG
MKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPPVAAEPATPLKAKEATKKKKKQFGKK

--------------------------------------------------------------
>9494_9494_3_BCOR-L3MBTL2_BCOR_chrX_39931602_ENST00000378444_L3MBTL2_chr22_41605700_ENST00000216237_length(transcript)=6340nt_BP=3226nt
GCTCGCCGCGCTTCTCCGGCCCGGCTCCTTCTCCGCTCGTTAACGTCGCCAACCCCCCCCACCCCTCATATCTCTCTCCACCCACCCAAC
CGCCCCCCGCTCCTTCTCGCCGCCTCGAGTCCGCTTGGGGGAAAACTTCAAAGAGCCGGATCGCAGGCTCCCTGCCTACTCCCCCACCGG
GGATTTCAGACTAGACGCTTGAAGCAAAGCTGCCATCCCAGAAGACGACATGCTCTCAGCAACCCCCCTGTATGGGAACGTTCACAGCTG
GATGAACAGCGAGAGGGTCCGCATGTGTGGGGCGAGCGAAGACAGGAAAATCCTTGTAAATGATGGTGACGCTTCAAAAGCCAGACTGGA
ACTGAGGGAAGAGAATCCCTTGAACCACAACGTGGTGGATGCGAGCACGGCCCATAGGATCGATGGCCTGGCAGCACTGAGCATGGACCG
CACTGGCCTGATCCGGGAAGGGCTGCGGGTCCCGGGAAACATCGTCTATTCTAGCTTGTGTGGACTGGGCTCAGAGAAAGGTCGGGAGGC
TGCCACAAGCACTCTAGGTGGCCTTGGGTTTTCTTCGGAAAGAAATCCAGAGATGCAGTTCAAACCGAATACACCCGAGACAGTGGAGGC
TTCTGCCGTCTCTGGAAAACCCCCAAATGGCTTCAGTGCTATATACAAAACACCGCCTGGAATACAAAAAAGTGCTGTAGCCACAGCAGA
AGCGCTGGGCTTGGACAGGCCTGCCAGCGACAAACAGAGCCCTCTCAACATCAATGGTGCTAGTTATCTGCGGCTGCCCTGGGTCAATCC
TTACATGGAGGGTGCCACGCCAGCCATCTACCCTTTCCTCGACTCGCCAAATAAGTATTCACTGAACATGTACAAGGCCTTGCTACCTCA
GCAGTCCTACAGCTTGGCCCAGCCGCTGTATTCTCCAGTCTGCACCAATGGGGAGCGCTTTCTCTACCTGCCGCCACCTCACTACGTCGG
TCCCCACATCCCATCGTCCTTGGCATCACCCATGAGGCTCTCGACACCTTCGGCCTCCCCAGCCATCCCGCCTCTCGTCCATTGCGCAGA
CAAAAGCCTCCCGTGGAAGATGGGCGTCAGCCCTGGGAATCCTGTTGATTCCCACGCCTATCCTCACATCCAGAACAGTAAGCAGCCCAG
GGTTCCCTCTGCCAAGGCGGTCACCAGTGGCCTGCCGGGGGACACAGCTCTCCTGTTGCCCCCCTCGCCTCGGCCGTCACCCCGAGTCCA
CCTTCCCACCCAGCCTGCTGCAGACACCTACTCGGAGTTCCACAAGCACTATGCCAGGATCTCCACCTCTCCTTCAGTTGCCCTGTCAAA
GCCATACATGACAGTTAGCAGCGAGTTCCCCGCGGCCAGGCTCTCCAATGGCAAGTATCCCAAGGCTCCGGAAGGGGGCGAAGGTGCCCA
GCCAGTGCCCGGGCATGCCCGGAAGACAGCGGTTCAAGACAGAAAAGATGGCAGCTCACCTCCTCTGTTGGAGAAGCAGACCGTTACCAA
AGACGTCACAGATAAGCCACTAGACTTGTCTTCTAAAGTGGTGGATGTAGATGCTTCCAAAGCTGACCACATGAAAAAGATGGCTCCCAC
GGTCCTGGTTCACAGCAGGGCTGGAAGTGGCTTAGTGCTCTCCGGAAGTGAGATTCCGAAAGAAACACTATCTCCTCCAGGAAATGGTTG
TGCTATCTATAGATCTGAAATCATCAGCACTGCTCCCTCATCCTGGGTGGTGCCCGGGCCAAGTCCTAACGAAGAGAACAATGGCAAAAG
CATGTCGCTGAAAAACAAGGCATTGGACTGGGCGATACCACAGCAGCGGAGTTCATCATGCCCGCGCATGGGCGGCACCGATGCTGTCAT
CACTAACGTTTCAGGGTCAGTGTCGAGTGCAGGCCGCCCAGCCTCCGCATCACCCGCCCCCAATGCCAATGCAGATGGCACCAAAACCAG
CAGGAGCTCTGTAGAAACCACACCATCCGTTATTCAGCACGTGGGCCAGCCCCCGGCCACTCCTGCCAAGCACAGTAGCAGCACCAGCAG
CAAGGGCGCCAAAGCCAGCAACCCAGAACCGAGTTTCAAAGCAAACGAGAACGGCCTTCCACCAAGCTCTATATTTCTGTCTCCAAATGA
GGCATTCAGGTCCCCACCAATTCCCTACCCCAGGAGTTACCTCCCTTACCCAGCCCCTGAGGGCATTGCTGTAAGTCCCCTCTCCTTACA
TGGCAAAGGACCTGTCTACCCTCACCCAGTTTTGTTACCCAATGGCAGTCTGTTTCCTGGGCACCTTGCCCCAAAGCCTGGGCTGCCCTA
TGGGCTTCCCACCGGCCGTCCAGAGTTTGTGACCTACCAAGATGCCCTGGGGTTGGGCATGGTGCATCCCATGTTGATACCACACACGCC
CATAGAGATTACTAAAGAGGAGAAACCAGAGAGGAGATCCCGGTCCCATGAGAGAGCCCGTTACGAGGACCCAACCCTCCGGAATCGGTT
TTCCGAGATTTTGGAAACTAGCAGCACCAAGTTACATCCAGATGTCCCCACCGACAAGAACCTAAAGCCGAACCCCAACTGGAATCAAGG
GAAGACTGTTGTCAAAAGCGACAAGCTTGTCTACGTAGACCTTCTCCGAGAAGAACCAGATGCTAAAACTGACACAAACGTGTCCAAACC
CAGCTTTGCAGCAGAGAGTGTTGGCCAGAGCGCTGAGCCCCCCAAGCCCTCAGTTGAGCCGGCCCTGCAGCAGCACCGTGATTTCATCGC
CCTGAGAGAGGAGTTGGGGCGCATCAGTGACTTCCACGAAACTTATACTTTCAAACAGCCAGTCTTCACCGTAAGCAAGGACAGTGTTCT
GGCAGGTACCAACAAAGAGAACCTAGGGTTGCCAGTCTCGACTCCATTCCTGGAGCCACCTCTGGGGAGCGATGGCCCTGCTGTAACTTT
TGGTAAAACCCAAGAGGATCCCAAACCATTTTGTGTGGGCAGTGCCCCACCAAGTGTGGATGTGACCCCCACCTATACCAAAGATGGAGC
TGATGAGGCTGAATCAAATGATGGCAAAGTTCTGAAACCGAAGCCATCTAAGCTGGCAAAGAGAATCGCCAACTCAGCGGGTTACGTGGG
TGACCGATTCAAATGTGTCACTACCGAACTGTATGCAGATTCCAGTCAGCTCAGCCGGGAGCAACGGGCATTGCAGGAGACCCCATCTTC
AGAACCAATGGAGGAAGAGGAAGATGACGACTTGGAGCTGTTTGGTGGCTATGATAGTTTCCGGAGTTATAACAGCAGTGTGGGCAGTGA
GAGCAGCTCCTATCTGGAGGAGTCAAGTGAAGCAGAAAATGAGGATCGGGAAGCAGGGGAACTGCCGACCTCCCCGCTGCATTTGCTCAG
CCCTGGGACTCCTCGCTCCTTGGATGGCAGTGGTTCTGAGCCAGCTGTCTGTGAGATGTGTGGTATCGTGGGTACAAGGGAAGCCTTCTT
CTCCAAGACCAAGAGGTTCTGCAGCGTCTCCTGCTCCAGGAGCTACTCCTCCAACTCCAAGAAAGCCAGTATCTTGGCTAGGTTACAGGG
AAAACCACCGACCAAAAAAGCCAAAGTCCTGCACAAGGCTGCCTGGTCTGCCAAAATTGGAGCCTTCCTCCACTCTCAAGGGACAGGACA
GCTGGCAGATGGGACACCAACAGGACAAGACGCTCTGGTCTTGGGCTTCGACTGGGGGAAGTTCCTGAAGGATCACAGTTACAAGGCTGC
TCCCGTCAGCTGTTTCAAGCACGTCCCACTCTATGACCAGTGGGAGGATGTGATGAAAGGGATGAAGGTGGAGGTGCTCAACAGTGATGC
TGTGCTCCCCAGCCGGGTGTACTGGATCGCCTCTGTCATCCAGACAGCAGGGTATCGGGTGCTGCTTCGGTATGAAGGCTTTGAAAATGA
CGCCAGCCATGACTTCTGGTGCAACCTGGGAACAGTGGATGTCCACCCCATTGGCTGGTGTGCCATCAACAGCAAGATCCTAGTGCCCCC
ACGGACCATCCATGCCAAGTTCACCGACTGGAAGGGCTACCTCATGAAACGGCTGGTGGGCTCCAGGACGCTTCCCGTGGATTTCCACAT
CAAGATGGTGGAGAGCATGAAGTACCCCTTTAGGCAGGGCATGCGGCTGGAAGTGGTGGACAAGTCCCAGGTGTCACGCACTCGCATGGC
TGTGGTGGACACAGTAATCGGGGGTCGCCTACGGCTCCTCTACGAGGATGGTGACAGTGACGACGACTTCTGGTGCCACATGTGGAGCCC
CCTGATCCACCCAGTGGGTTGGTCACGACGTGTGGGCCACGGCATCAAGATGTCAGAGAGGCGAAGTGACATGGCCCATCACCCCACCTT
CCGGAAGATCTACTGTGATGCCGTTCCTTACCTCTTCAAGAAGGTACGAGCAGTCTACACAGAAGGCGGTTGGTTTGAGGAAGGGATGAA
GCTGGAGGCCATTGACCCCCTGAATCTGGGCAACATCTGCGTGGCAACTGTCTGTAAGGTTCTCCTGGATGGATACCTGATGATCTGTGT
GGACGGGGGGCCCTCCACAGATGGCTTGGACTGGTTCTGCTACCATGCCTCTTCCCACGCCATCTTCCCGGCCACCTTCTGTCAGAAGAA
TGACATTGAGCTCACACCGCCAAAAGGTTATGAGGCACAGACTTTCAACTGGGAGAACTACTTGGAGAAGACCAAGTCGAAAGCCGCTCC
ATCGAGACTCTTTAACATGGATTGCCCAAACCATGGCTTCAAGGTGGGCATGAAGCTGGAGGCCGTGGACCTGATGGAGCCCCGGCTCAT
CTGTGTGGCCACGGTGAAACGAGTGGTGCATCGGCTCCTCAGCATCCACTTTGACGGCTGGGACAGCGAGTACGACCAGTGGGTGGACTG
CGAGTCCCCAGACATCTACCCCGTCGGCTGGTGTGAGCTCACCGGCTACCAGCTCCAGCCTCCTGTGGCCGCAGAACCGGCCACACCGCT
GAAGGCCAAAGAGGCCACAAAGAAGAAAAAGAAACAGTTTGGGAAGAAAAGGAAAAGAATCCCGCCCACTAAGACGCGACCCCTCAGACA
GGGGTCCAAGAAGCCCCTGCTGGAGGACGACCCTCAGGGTGCCAGGAAGATCTCGTCGGAGCCTGTTCCTGGCGAGATCATTGCTGTGCG
TGTGAAGGAAGAGCATCTAGACGTGGCCTCGCCCGACAAGGCTTCAAGTCCAGAGCTGCCTGTCTCCGTCGAGAACATCAAGCAGGAAAC
AGACGACTGAGCCTTCCTGCCTCCAGCCTGGCTTCTAGCTGGAAGCCAGCCCAGCGTTTCTCTACCACCACCACCATGCCTCCACCTGAC
TTTGGCTTGGAGACTGATCCTCTCTGTGTAAATTCTGCCCGGTGCTGTGAAGGCTGGACGGTGGAGGACCTGCTGGGGTCTCCTGGGACC
CGCCTGTTGCTTCTGCCCTCCCCTGTGGAAAGGTCTATATGACGGGCCGCCTGAGGCCCCAGAACTCGTCTGTGAACCACCTTTTCCAGC
CAGAGTTCCCAAAGCTGGAACGCTAGCTGCCTGCTCTTCCTTAAGATGGCCTCCCCCCGACCCGCCACGGCCCTCAGTTGCCAGGGATGG
GGCCACCACTGTCACACTGTGGAATACAAGACAGTGAACTCTGTCTGCCTGAACGAGCCATGTAAATTAAGTTCTAGAGCAGCTCTCTGA
GCAGGATAAGGTCCCCTGACAGTGAGTTGTGTGGTGGGGGCAGCCTCTGCCTCAAAAATTCACCAAGCAGAATGCCTCTCAGCCTCATGT
GTTGGTCCTCTGCTCCTCCTAGCTCCCCAGGGATGTTGGGGACCCAGCTTGTCTCGGCAGCTAAGAAGCAGTGACCAGGATGTGGATTTT
GGCGACCTGTGTGGTGGCCTTGAGCTGCTTTCTGTGTTTGTGAGGACTGACTCCCATTTCCTAAAGGAAATGCCCCCGGGGAGGACATTG
GGAGGAAGATGGCCTGAGTGTGCACTTTGGCTCTGCTACCTGCTCCTGAAGCCCCGCTAAAAATAATTCATCCAAGATTCCTTTGTAGTT
AAAGGGTCCAGTTCTGACTGGAGCCTCTAGAGAGCTGGGCTTGTATGTTCTTTTGGCCTTTTGTTCCTACCTAAATGAAGAAACCATGCC
TGGAGGGGCCGTGAACACAGAACCCTCAAGACAAGGATGACAGAGCTGGAGGACACATCTAGCTGCCATTGCAACCTCACTGGGCTCCCC

>9494_9494_3_BCOR-L3MBTL2_BCOR_chrX_39931602_ENST00000378444_L3MBTL2_chr22_41605700_ENST00000216237_length(amino acids)=1696AA_BP=999
MLSATPLYGNVHSWMNSERVRMCGASEDRKILVNDGDASKARLELREENPLNHNVVDASTAHRIDGLAALSMDRTGLIREGLRVPGNIVY
SSLCGLGSEKGREAATSTLGGLGFSSERNPEMQFKPNTPETVEASAVSGKPPNGFSAIYKTPPGIQKSAVATAEALGLDRPASDKQSPLN
INGASYLRLPWVNPYMEGATPAIYPFLDSPNKYSLNMYKALLPQQSYSLAQPLYSPVCTNGERFLYLPPPHYVGPHIPSSLASPMRLSTP
SASPAIPPLVHCADKSLPWKMGVSPGNPVDSHAYPHIQNSKQPRVPSAKAVTSGLPGDTALLLPPSPRPSPRVHLPTQPAADTYSEFHKH
YARISTSPSVALSKPYMTVSSEFPAARLSNGKYPKAPEGGEGAQPVPGHARKTAVQDRKDGSSPPLLEKQTVTKDVTDKPLDLSSKVVDV
DASKADHMKKMAPTVLVHSRAGSGLVLSGSEIPKETLSPPGNGCAIYRSEIISTAPSSWVVPGPSPNEENNGKSMSLKNKALDWAIPQQR
SSSCPRMGGTDAVITNVSGSVSSAGRPASASPAPNANADGTKTSRSSVETTPSVIQHVGQPPATPAKHSSSTSSKGAKASNPEPSFKANE
NGLPPSSIFLSPNEAFRSPPIPYPRSYLPYPAPEGIAVSPLSLHGKGPVYPHPVLLPNGSLFPGHLAPKPGLPYGLPTGRPEFVTYQDAL
GLGMVHPMLIPHTPIEITKEEKPERRSRSHERARYEDPTLRNRFSEILETSSTKLHPDVPTDKNLKPNPNWNQGKTVVKSDKLVYVDLLR
EEPDAKTDTNVSKPSFAAESVGQSAEPPKPSVEPALQQHRDFIALREELGRISDFHETYTFKQPVFTVSKDSVLAGTNKENLGLPVSTPF
LEPPLGSDGPAVTFGKTQEDPKPFCVGSAPPSVDVTPTYTKDGADEAESNDGKVLKPKPSKLAKRIANSAGYVGDRFKCVTTELYADSSQ
LSREQRALQETPSSEPMEEEEDDDLELFGGYDSFRSYNSSVGSESSSYLEESSEAENEDREAGELPTSPLHLLSPGTPRSLDGSGSEPAV
CEMCGIVGTREAFFSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTKKAKVLHKAAWSAKIGAFLHSQGTGQLADGTPTGQDALVLGF
DWGKFLKDHSYKAAPVSCFKHVPLYDQWEDVMKGMKVEVLNSDAVLPSRVYWIASVIQTAGYRVLLRYEGFENDASHDFWCNLGTVDVHP
IGWCAINSKILVPPRTIHAKFTDWKGYLMKRLVGSRTLPVDFHIKMVESMKYPFRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYED
GDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRSDMAHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGNICVAT
VCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATFCQKNDIELTPPKGYEAQTFNWENYLEKTKSKAAPSRLFNMDCPNHGFKVG
MKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPPVAAEPATPLKAKEATKKKKKQFGKK

--------------------------------------------------------------
>9494_9494_4_BCOR-L3MBTL2_BCOR_chrX_39931602_ENST00000397354_L3MBTL2_chr22_41605700_ENST00000216237_length(transcript)=6340nt_BP=3226nt
GCTCGCCGCGCTTCTCCGGCCCGGCTCCTTCTCCGCTCGTTAACGTCGCCAACCCCCCCCACCCCTCATATCTCTCTCCACCCACCCAAC
CGCCCCCCGCTCCTTCTCGCCGCCTCGAGTCCGCTTGGGGGAAAACTTCAAAGAGCCGGATCGCAGGCTCCCTGCCTACTCCCCCACCGG
GGATTTCAGACTAGACGCTTGAAGCAAAGCTGCCATCCCAGAAGACGACATGCTCTCAGCAACCCCCCTGTATGGGAACGTTCACAGCTG
GATGAACAGCGAGAGGGTCCGCATGTGTGGGGCGAGCGAAGACAGGAAAATCCTTGTAAATGATGGTGACGCTTCAAAAGCCAGACTGGA
ACTGAGGGAAGAGAATCCCTTGAACCACAACGTGGTGGATGCGAGCACGGCCCATAGGATCGATGGCCTGGCAGCACTGAGCATGGACCG
CACTGGCCTGATCCGGGAAGGGCTGCGGGTCCCGGGAAACATCGTCTATTCTAGCTTGTGTGGACTGGGCTCAGAGAAAGGTCGGGAGGC
TGCCACAAGCACTCTAGGTGGCCTTGGGTTTTCTTCGGAAAGAAATCCAGAGATGCAGTTCAAACCGAATACACCCGAGACAGTGGAGGC
TTCTGCCGTCTCTGGAAAACCCCCAAATGGCTTCAGTGCTATATACAAAACACCGCCTGGAATACAAAAAAGTGCTGTAGCCACAGCAGA
AGCGCTGGGCTTGGACAGGCCTGCCAGCGACAAACAGAGCCCTCTCAACATCAATGGTGCTAGTTATCTGCGGCTGCCCTGGGTCAATCC
TTACATGGAGGGTGCCACGCCAGCCATCTACCCTTTCCTCGACTCGCCAAATAAGTATTCACTGAACATGTACAAGGCCTTGCTACCTCA
GCAGTCCTACAGCTTGGCCCAGCCGCTGTATTCTCCAGTCTGCACCAATGGGGAGCGCTTTCTCTACCTGCCGCCACCTCACTACGTCGG
TCCCCACATCCCATCGTCCTTGGCATCACCCATGAGGCTCTCGACACCTTCGGCCTCCCCAGCCATCCCGCCTCTCGTCCATTGCGCAGA
CAAAAGCCTCCCGTGGAAGATGGGCGTCAGCCCTGGGAATCCTGTTGATTCCCACGCCTATCCTCACATCCAGAACAGTAAGCAGCCCAG
GGTTCCCTCTGCCAAGGCGGTCACCAGTGGCCTGCCGGGGGACACAGCTCTCCTGTTGCCCCCCTCGCCTCGGCCGTCACCCCGAGTCCA
CCTTCCCACCCAGCCTGCTGCAGACACCTACTCGGAGTTCCACAAGCACTATGCCAGGATCTCCACCTCTCCTTCAGTTGCCCTGTCAAA
GCCATACATGACAGTTAGCAGCGAGTTCCCCGCGGCCAGGCTCTCCAATGGCAAGTATCCCAAGGCTCCGGAAGGGGGCGAAGGTGCCCA
GCCAGTGCCCGGGCATGCCCGGAAGACAGCGGTTCAAGACAGAAAAGATGGCAGCTCACCTCCTCTGTTGGAGAAGCAGACCGTTACCAA
AGACGTCACAGATAAGCCACTAGACTTGTCTTCTAAAGTGGTGGATGTAGATGCTTCCAAAGCTGACCACATGAAAAAGATGGCTCCCAC
GGTCCTGGTTCACAGCAGGGCTGGAAGTGGCTTAGTGCTCTCCGGAAGTGAGATTCCGAAAGAAACACTATCTCCTCCAGGAAATGGTTG
TGCTATCTATAGATCTGAAATCATCAGCACTGCTCCCTCATCCTGGGTGGTGCCCGGGCCAAGTCCTAACGAAGAGAACAATGGCAAAAG
CATGTCGCTGAAAAACAAGGCATTGGACTGGGCGATACCACAGCAGCGGAGTTCATCATGCCCGCGCATGGGCGGCACCGATGCTGTCAT
CACTAACGTTTCAGGGTCAGTGTCGAGTGCAGGCCGCCCAGCCTCCGCATCACCCGCCCCCAATGCCAATGCAGATGGCACCAAAACCAG
CAGGAGCTCTGTAGAAACCACACCATCCGTTATTCAGCACGTGGGCCAGCCCCCGGCCACTCCTGCCAAGCACAGTAGCAGCACCAGCAG
CAAGGGCGCCAAAGCCAGCAACCCAGAACCGAGTTTCAAAGCAAACGAGAACGGCCTTCCACCAAGCTCTATATTTCTGTCTCCAAATGA
GGCATTCAGGTCCCCACCAATTCCCTACCCCAGGAGTTACCTCCCTTACCCAGCCCCTGAGGGCATTGCTGTAAGTCCCCTCTCCTTACA
TGGCAAAGGACCTGTCTACCCTCACCCAGTTTTGTTACCCAATGGCAGTCTGTTTCCTGGGCACCTTGCCCCAAAGCCTGGGCTGCCCTA
TGGGCTTCCCACCGGCCGTCCAGAGTTTGTGACCTACCAAGATGCCCTGGGGTTGGGCATGGTGCATCCCATGTTGATACCACACACGCC
CATAGAGATTACTAAAGAGGAGAAACCAGAGAGGAGATCCCGGTCCCATGAGAGAGCCCGTTACGAGGACCCAACCCTCCGGAATCGGTT
TTCCGAGATTTTGGAAACTAGCAGCACCAAGTTACATCCAGATGTCCCCACCGACAAGAACCTAAAGCCGAACCCCAACTGGAATCAAGG
GAAGACTGTTGTCAAAAGCGACAAGCTTGTCTACGTAGACCTTCTCCGAGAAGAACCAGATGCTAAAACTGACACAAACGTGTCCAAACC
CAGCTTTGCAGCAGAGAGTGTTGGCCAGAGCGCTGAGCCCCCCAAGCCCTCAGTTGAGCCGGCCCTGCAGCAGCACCGTGATTTCATCGC
CCTGAGAGAGGAGTTGGGGCGCATCAGTGACTTCCACGAAACTTATACTTTCAAACAGCCAGTCTTCACCGTAAGCAAGGACAGTGTTCT
GGCAGGTACCAACAAAGAGAACCTAGGGTTGCCAGTCTCGACTCCATTCCTGGAGCCACCTCTGGGGAGCGATGGCCCTGCTGTAACTTT
TGGTAAAACCCAAGAGGATCCCAAACCATTTTGTGTGGGCAGTGCCCCACCAAGTGTGGATGTGACCCCCACCTATACCAAAGATGGAGC
TGATGAGGCTGAATCAAATGATGGCAAAGTTCTGAAACCGAAGCCATCTAAGCTGGCAAAGAGAATCGCCAACTCAGCGGGTTACGTGGG
TGACCGATTCAAATGTGTCACTACCGAACTGTATGCAGATTCCAGTCAGCTCAGCCGGGAGCAACGGGCATTGCAGGAGACCCCATCTTC
AGAACCAATGGAGGAAGAGGAAGATGACGACTTGGAGCTGTTTGGTGGCTATGATAGTTTCCGGAGTTATAACAGCAGTGTGGGCAGTGA
GAGCAGCTCCTATCTGGAGGAGTCAAGTGAAGCAGAAAATGAGGATCGGGAAGCAGGGGAACTGCCGACCTCCCCGCTGCATTTGCTCAG
CCCTGGGACTCCTCGCTCCTTGGATGGCAGTGGTTCTGAGCCAGCTGTCTGTGAGATGTGTGGTATCGTGGGTACAAGGGAAGCCTTCTT
CTCCAAGACCAAGAGGTTCTGCAGCGTCTCCTGCTCCAGGAGCTACTCCTCCAACTCCAAGAAAGCCAGTATCTTGGCTAGGTTACAGGG
AAAACCACCGACCAAAAAAGCCAAAGTCCTGCACAAGGCTGCCTGGTCTGCCAAAATTGGAGCCTTCCTCCACTCTCAAGGGACAGGACA
GCTGGCAGATGGGACACCAACAGGACAAGACGCTCTGGTCTTGGGCTTCGACTGGGGGAAGTTCCTGAAGGATCACAGTTACAAGGCTGC
TCCCGTCAGCTGTTTCAAGCACGTCCCACTCTATGACCAGTGGGAGGATGTGATGAAAGGGATGAAGGTGGAGGTGCTCAACAGTGATGC
TGTGCTCCCCAGCCGGGTGTACTGGATCGCCTCTGTCATCCAGACAGCAGGGTATCGGGTGCTGCTTCGGTATGAAGGCTTTGAAAATGA
CGCCAGCCATGACTTCTGGTGCAACCTGGGAACAGTGGATGTCCACCCCATTGGCTGGTGTGCCATCAACAGCAAGATCCTAGTGCCCCC
ACGGACCATCCATGCCAAGTTCACCGACTGGAAGGGCTACCTCATGAAACGGCTGGTGGGCTCCAGGACGCTTCCCGTGGATTTCCACAT
CAAGATGGTGGAGAGCATGAAGTACCCCTTTAGGCAGGGCATGCGGCTGGAAGTGGTGGACAAGTCCCAGGTGTCACGCACTCGCATGGC
TGTGGTGGACACAGTAATCGGGGGTCGCCTACGGCTCCTCTACGAGGATGGTGACAGTGACGACGACTTCTGGTGCCACATGTGGAGCCC
CCTGATCCACCCAGTGGGTTGGTCACGACGTGTGGGCCACGGCATCAAGATGTCAGAGAGGCGAAGTGACATGGCCCATCACCCCACCTT
CCGGAAGATCTACTGTGATGCCGTTCCTTACCTCTTCAAGAAGGTACGAGCAGTCTACACAGAAGGCGGTTGGTTTGAGGAAGGGATGAA
GCTGGAGGCCATTGACCCCCTGAATCTGGGCAACATCTGCGTGGCAACTGTCTGTAAGGTTCTCCTGGATGGATACCTGATGATCTGTGT
GGACGGGGGGCCCTCCACAGATGGCTTGGACTGGTTCTGCTACCATGCCTCTTCCCACGCCATCTTCCCGGCCACCTTCTGTCAGAAGAA
TGACATTGAGCTCACACCGCCAAAAGGTTATGAGGCACAGACTTTCAACTGGGAGAACTACTTGGAGAAGACCAAGTCGAAAGCCGCTCC
ATCGAGACTCTTTAACATGGATTGCCCAAACCATGGCTTCAAGGTGGGCATGAAGCTGGAGGCCGTGGACCTGATGGAGCCCCGGCTCAT
CTGTGTGGCCACGGTGAAACGAGTGGTGCATCGGCTCCTCAGCATCCACTTTGACGGCTGGGACAGCGAGTACGACCAGTGGGTGGACTG
CGAGTCCCCAGACATCTACCCCGTCGGCTGGTGTGAGCTCACCGGCTACCAGCTCCAGCCTCCTGTGGCCGCAGAACCGGCCACACCGCT
GAAGGCCAAAGAGGCCACAAAGAAGAAAAAGAAACAGTTTGGGAAGAAAAGGAAAAGAATCCCGCCCACTAAGACGCGACCCCTCAGACA
GGGGTCCAAGAAGCCCCTGCTGGAGGACGACCCTCAGGGTGCCAGGAAGATCTCGTCGGAGCCTGTTCCTGGCGAGATCATTGCTGTGCG
TGTGAAGGAAGAGCATCTAGACGTGGCCTCGCCCGACAAGGCTTCAAGTCCAGAGCTGCCTGTCTCCGTCGAGAACATCAAGCAGGAAAC
AGACGACTGAGCCTTCCTGCCTCCAGCCTGGCTTCTAGCTGGAAGCCAGCCCAGCGTTTCTCTACCACCACCACCATGCCTCCACCTGAC
TTTGGCTTGGAGACTGATCCTCTCTGTGTAAATTCTGCCCGGTGCTGTGAAGGCTGGACGGTGGAGGACCTGCTGGGGTCTCCTGGGACC
CGCCTGTTGCTTCTGCCCTCCCCTGTGGAAAGGTCTATATGACGGGCCGCCTGAGGCCCCAGAACTCGTCTGTGAACCACCTTTTCCAGC
CAGAGTTCCCAAAGCTGGAACGCTAGCTGCCTGCTCTTCCTTAAGATGGCCTCCCCCCGACCCGCCACGGCCCTCAGTTGCCAGGGATGG
GGCCACCACTGTCACACTGTGGAATACAAGACAGTGAACTCTGTCTGCCTGAACGAGCCATGTAAATTAAGTTCTAGAGCAGCTCTCTGA
GCAGGATAAGGTCCCCTGACAGTGAGTTGTGTGGTGGGGGCAGCCTCTGCCTCAAAAATTCACCAAGCAGAATGCCTCTCAGCCTCATGT
GTTGGTCCTCTGCTCCTCCTAGCTCCCCAGGGATGTTGGGGACCCAGCTTGTCTCGGCAGCTAAGAAGCAGTGACCAGGATGTGGATTTT
GGCGACCTGTGTGGTGGCCTTGAGCTGCTTTCTGTGTTTGTGAGGACTGACTCCCATTTCCTAAAGGAAATGCCCCCGGGGAGGACATTG
GGAGGAAGATGGCCTGAGTGTGCACTTTGGCTCTGCTACCTGCTCCTGAAGCCCCGCTAAAAATAATTCATCCAAGATTCCTTTGTAGTT
AAAGGGTCCAGTTCTGACTGGAGCCTCTAGAGAGCTGGGCTTGTATGTTCTTTTGGCCTTTTGTTCCTACCTAAATGAAGAAACCATGCC
TGGAGGGGCCGTGAACACAGAACCCTCAAGACAAGGATGACAGAGCTGGAGGACACATCTAGCTGCCATTGCAACCTCACTGGGCTCCCC

>9494_9494_4_BCOR-L3MBTL2_BCOR_chrX_39931602_ENST00000397354_L3MBTL2_chr22_41605700_ENST00000216237_length(amino acids)=1696AA_BP=999
MLSATPLYGNVHSWMNSERVRMCGASEDRKILVNDGDASKARLELREENPLNHNVVDASTAHRIDGLAALSMDRTGLIREGLRVPGNIVY
SSLCGLGSEKGREAATSTLGGLGFSSERNPEMQFKPNTPETVEASAVSGKPPNGFSAIYKTPPGIQKSAVATAEALGLDRPASDKQSPLN
INGASYLRLPWVNPYMEGATPAIYPFLDSPNKYSLNMYKALLPQQSYSLAQPLYSPVCTNGERFLYLPPPHYVGPHIPSSLASPMRLSTP
SASPAIPPLVHCADKSLPWKMGVSPGNPVDSHAYPHIQNSKQPRVPSAKAVTSGLPGDTALLLPPSPRPSPRVHLPTQPAADTYSEFHKH
YARISTSPSVALSKPYMTVSSEFPAARLSNGKYPKAPEGGEGAQPVPGHARKTAVQDRKDGSSPPLLEKQTVTKDVTDKPLDLSSKVVDV
DASKADHMKKMAPTVLVHSRAGSGLVLSGSEIPKETLSPPGNGCAIYRSEIISTAPSSWVVPGPSPNEENNGKSMSLKNKALDWAIPQQR
SSSCPRMGGTDAVITNVSGSVSSAGRPASASPAPNANADGTKTSRSSVETTPSVIQHVGQPPATPAKHSSSTSSKGAKASNPEPSFKANE
NGLPPSSIFLSPNEAFRSPPIPYPRSYLPYPAPEGIAVSPLSLHGKGPVYPHPVLLPNGSLFPGHLAPKPGLPYGLPTGRPEFVTYQDAL
GLGMVHPMLIPHTPIEITKEEKPERRSRSHERARYEDPTLRNRFSEILETSSTKLHPDVPTDKNLKPNPNWNQGKTVVKSDKLVYVDLLR
EEPDAKTDTNVSKPSFAAESVGQSAEPPKPSVEPALQQHRDFIALREELGRISDFHETYTFKQPVFTVSKDSVLAGTNKENLGLPVSTPF
LEPPLGSDGPAVTFGKTQEDPKPFCVGSAPPSVDVTPTYTKDGADEAESNDGKVLKPKPSKLAKRIANSAGYVGDRFKCVTTELYADSSQ
LSREQRALQETPSSEPMEEEEDDDLELFGGYDSFRSYNSSVGSESSSYLEESSEAENEDREAGELPTSPLHLLSPGTPRSLDGSGSEPAV
CEMCGIVGTREAFFSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTKKAKVLHKAAWSAKIGAFLHSQGTGQLADGTPTGQDALVLGF
DWGKFLKDHSYKAAPVSCFKHVPLYDQWEDVMKGMKVEVLNSDAVLPSRVYWIASVIQTAGYRVLLRYEGFENDASHDFWCNLGTVDVHP
IGWCAINSKILVPPRTIHAKFTDWKGYLMKRLVGSRTLPVDFHIKMVESMKYPFRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYED
GDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRSDMAHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGNICVAT
VCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATFCQKNDIELTPPKGYEAQTFNWENYLEKTKSKAAPSRLFNMDCPNHGFKVG
MKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPPVAAEPATPLKAKEATKKKKKQFGKK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BCOR-L3MBTL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneBCORchrX:39931601chr22:41605699ENST00000342274-415498_514999.01722.0BCL6
HgeneBCORchrX:39931601chr22:41605699ENST00000378444-415498_514999.01756.0BCL6
HgeneBCORchrX:39931601chr22:41605699ENST00000378455-414498_514999.01704.0BCL6
HgeneBCORchrX:39931601chr22:41605699ENST00000397354-415498_514999.01722.0BCL6
HgeneBCORchrX:39931602chr22:41605700ENST00000342274-415498_514999.01722.0BCL6
HgeneBCORchrX:39931602chr22:41605700ENST00000378444-415498_514999.01756.0BCL6
HgeneBCORchrX:39931602chr22:41605700ENST00000378455-414498_514999.01704.0BCL6
HgeneBCORchrX:39931602chr22:41605700ENST00000397354-415498_514999.01722.0BCL6


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BCOR-L3MBTL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BCOR-L3MBTL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBCORC1846265Microphthalmia, syndromic 24CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneBCORC0023487Acute Promyelocytic Leukemia2ORPHANET
HgeneBCORC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneBCORC0022665Kidney Neoplasm1CTD_human
HgeneBCORC0027708Nephroblastoma1CTD_human
HgeneBCORC0029463Osteosarcoma1CTD_human
HgeneBCORC0206651Clear Cell Sarcoma of Soft Tissue1CTD_human
HgeneBCORC0206656Embryonal Rhabdomyosarcoma1CTD_human
HgeneBCORC0334488Clear cell sarcoma of kidney1ORPHANET
HgeneBCORC0740457Malignant neoplasm of kidney1CTD_human
HgeneBCORC0796016Microphthalmia, syndromic 11CTD_human;ORPHANET
HgeneBCORC2930471Bilateral Wilms Tumor1CTD_human
TgeneC0025149Medulloblastoma1CTD_human
TgeneC0205833Medullomyoblastoma1CTD_human
TgeneC0278510Childhood Medulloblastoma1CTD_human
TgeneC0278876Adult Medulloblastoma1CTD_human
TgeneC0751291Desmoplastic Medulloblastoma1CTD_human
TgeneC1275668Melanotic medulloblastoma1CTD_human