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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CASZ1-ALG14 (FusionGDB2 ID:HG54897TG199857) |
Fusion Gene Summary for CASZ1-ALG14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CASZ1-ALG14 | Fusion gene ID: hg54897tg199857 | Hgene | Tgene | Gene symbol | CASZ1 | ALG14 | Gene ID | 54897 | 199857 |
| Gene name | castor zinc finger 1 | ALG14 UDP-N-acetylglucosaminyltransferase subunit | |
| Synonyms | CAS11|CST|SRG|ZNF693|dJ734G22.1 | CMS15 | |
| Cytomap | ('CASZ1')('ALG14') 1p36.22 | 1p21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein castor homolog 1castor homolog 1, zinc fingercastor-related proteinsurvival-relatedzinc finger protein 693 | UDP-N-acetylglucosamine transferase subunit ALG14 homolog | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q96F25 | |
| Ensembl transtripts involved in fusion gene | ENST00000344008, ENST00000377022, ENST00000478728, | ||
| Fusion gene scores | * DoF score | 23 X 19 X 12=5244 | 7 X 7 X 5=245 |
| # samples | 30 | 10 | |
| ** MAII score | log2(30/5244*10)=-4.12763327972587 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/245*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CASZ1 [Title/Abstract] AND ALG14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CASZ1(10753931)-ALG14(95530573), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | CASZ1-ALG14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CASZ1-ALG14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CASZ1 | GO:0045893 | positive regulation of transcription, DNA-templated | 27693370 |
| Fusion gene breakpoints across CASZ1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ALG14 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | UCEC | TCGA-AX-A3G4-01A | CASZ1 | chr1 | 10753931 | - | ALG14 | chr1 | 95530573 | - |
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Fusion Gene ORF analysis for CASZ1-ALG14 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000344008 | ENST00000495856 | CASZ1 | chr1 | 10753931 | - | ALG14 | chr1 | 95530573 | - |
| 5CDS-5UTR | ENST00000377022 | ENST00000495856 | CASZ1 | chr1 | 10753931 | - | ALG14 | chr1 | 95530573 | - |
| 5UTR-3CDS | ENST00000478728 | ENST00000370205 | CASZ1 | chr1 | 10753931 | - | ALG14 | chr1 | 95530573 | - |
| 5UTR-5UTR | ENST00000478728 | ENST00000495856 | CASZ1 | chr1 | 10753931 | - | ALG14 | chr1 | 95530573 | - |
| In-frame | ENST00000344008 | ENST00000370205 | CASZ1 | chr1 | 10753931 | - | ALG14 | chr1 | 95530573 | - |
| In-frame | ENST00000377022 | ENST00000370205 | CASZ1 | chr1 | 10753931 | - | ALG14 | chr1 | 95530573 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000377022 | CASZ1 | chr1 | 10753931 | - | ENST00000370205 | ALG14 | chr1 | 95530573 | - | 9518 | 334 | 285 | 848 | 187 |
| ENST00000344008 | CASZ1 | chr1 | 10753931 | - | ENST00000370205 | ALG14 | chr1 | 95530573 | - | 9520 | 336 | 287 | 850 | 187 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000377022 | ENST00000370205 | CASZ1 | chr1 | 10753931 | - | ALG14 | chr1 | 95530573 | - | 0.007265879 | 0.9927341 |
| ENST00000344008 | ENST00000370205 | CASZ1 | chr1 | 10753931 | - | ALG14 | chr1 | 95530573 | - | 0.007243934 | 0.99275607 |
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Fusion Genomic Features for CASZ1-ALG14 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for CASZ1-ALG14 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:10753931/chr1:95530573) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | ALG14 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER. {ECO:0000269|PubMed:16100110}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000344008 | - | 4 | 16 | 1080_1143 | 5 | 1167.0 | Compositional bias | Note=Pro-rich |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000344008 | - | 4 | 16 | 1635_1670 | 5 | 1167.0 | Compositional bias | Note=Ala-rich |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000344008 | - | 4 | 16 | 1672_1729 | 5 | 1167.0 | Compositional bias | Note=Glu-rich |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000344008 | - | 4 | 16 | 1691_1718 | 5 | 1167.0 | Compositional bias | Note=Asp-rich |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000344008 | - | 4 | 16 | 384_417 | 5 | 1167.0 | Compositional bias | Note=Pro-rich |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000377022 | - | 4 | 21 | 1080_1143 | 5 | 1760.0 | Compositional bias | Note=Pro-rich |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000377022 | - | 4 | 21 | 1635_1670 | 5 | 1760.0 | Compositional bias | Note=Ala-rich |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000377022 | - | 4 | 21 | 1672_1729 | 5 | 1760.0 | Compositional bias | Note=Glu-rich |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000377022 | - | 4 | 21 | 1691_1718 | 5 | 1760.0 | Compositional bias | Note=Asp-rich |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000377022 | - | 4 | 21 | 384_417 | 5 | 1760.0 | Compositional bias | Note=Pro-rich |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000344008 | - | 4 | 16 | 1031_1055 | 5 | 1167.0 | Zinc finger | C2H2-type 4 |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000344008 | - | 4 | 16 | 1300_1324 | 5 | 1167.0 | Zinc finger | C2H2-type 5 |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000344008 | - | 4 | 16 | 1457_1481 | 5 | 1167.0 | Zinc finger | C2H2-type 6 |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000344008 | - | 4 | 16 | 1515_1537 | 5 | 1167.0 | Zinc finger | C2H2-type 7 |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000344008 | - | 4 | 16 | 1571_1595 | 5 | 1167.0 | Zinc finger | C2H2-type 8 |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000344008 | - | 4 | 16 | 551_575 | 5 | 1167.0 | Zinc finger | C2H2-type 1 |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000344008 | - | 4 | 16 | 610_634 | 5 | 1167.0 | Zinc finger | C2H2-type 2 |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000344008 | - | 4 | 16 | 668_692 | 5 | 1167.0 | Zinc finger | C2H2-type 3 |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000377022 | - | 4 | 21 | 1031_1055 | 5 | 1760.0 | Zinc finger | C2H2-type 4 |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000377022 | - | 4 | 21 | 1300_1324 | 5 | 1760.0 | Zinc finger | C2H2-type 5 |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000377022 | - | 4 | 21 | 1457_1481 | 5 | 1760.0 | Zinc finger | C2H2-type 6 |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000377022 | - | 4 | 21 | 1515_1537 | 5 | 1760.0 | Zinc finger | C2H2-type 7 |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000377022 | - | 4 | 21 | 1571_1595 | 5 | 1760.0 | Zinc finger | C2H2-type 8 |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000377022 | - | 4 | 21 | 551_575 | 5 | 1760.0 | Zinc finger | C2H2-type 1 |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000377022 | - | 4 | 21 | 610_634 | 5 | 1760.0 | Zinc finger | C2H2-type 2 |
| Hgene | CASZ1 | chr1:10753931 | chr1:95530573 | ENST00000377022 | - | 4 | 21 | 668_692 | 5 | 1760.0 | Zinc finger | C2H2-type 3 |
| Tgene | ALG14 | chr1:10753931 | chr1:95530573 | ENST00000370205 | 0 | 4 | 1_3 | 45 | 217.0 | Topological domain | Lumenal | |
| Tgene | ALG14 | chr1:10753931 | chr1:95530573 | ENST00000370205 | 0 | 4 | 25_216 | 45 | 217.0 | Topological domain | Cytoplasmic | |
| Tgene | ALG14 | chr1:10753931 | chr1:95530573 | ENST00000370205 | 0 | 4 | 4_24 | 45 | 217.0 | Transmembrane | Helical |
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Fusion Gene Sequence for CASZ1-ALG14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >13274_13274_1_CASZ1-ALG14_CASZ1_chr1_10753931_ENST00000344008_ALG14_chr1_95530573_ENST00000370205_length(transcript)=9520nt_BP=336nt GCATGCGCGCCCGCGGCGCTCCATCCCAAACACACACACATTTTTCCCCCGGACTTGGAAAGTCACCCAAAGCCGCCCCAAGTGCAGGCA AACAGACCTTGCTGACTGAAGGCAAAGACTCCTCCATCCCACCTGCCCTCCCAGCTGCCACGGCCATCGACCCCTCCTTTACAAGGGGCT CCTGCAACTCCCCAGCAGCACGTGTTGGAATGGACTTCGGACCCTGGCCTCTTGGGATGCAAAGGATGAAGTGACACCCCCAGCTACATC CGAGGAGGTTCTAGGACCTGCTACGAGAGTTTGGGACCAAGGAGAAGAGAATGGATCTTGGAACAGGTGGGCATACCACTGAGATCCTGA GGCTGCTTGGGAGCTTGTCCAATGCCTACTCACCTAGACATTATGTCATTGCTGACACTGATGAAATGAGTGCCAATAAAATAAATTCTT TTGAACTAGATCGAGCTGATAGAGACCCTAGTAACATGTATACCAAATACTACATTCACCGAATTCCAAGAAGCCGGGAGGTTCAGCAGT CCTGGCCCTCCACCGTTTTCACCACCTTGCACTCCATGTGGCTCTCCTTTCCCCTAATTCACAGGGTGAAGCCAGATTTGGTGTTGTGTA ACGGACCAGGAACATGTGTTCCTATCTGTGTATCTGCCCTTCTCCTTGGGATACTAGGAATAAAGAAAGTGATCATTGTCTACGTTGAAA GCATCTGCCGTGTAGAAACGTTATCCATGTCCGGAAAGATTCTGTTTCATCTCTCAGATTACTTCATTGTTCAGTGGCCGGCTCTGAAAG AAAAGTATCCCAAATCGGTGTACCTTGGGCGAATTGTTTGACAAATGGCAACTGACTTCTTTAGAATTTTGCAGTTAACAGTAGTATGTA CTCAAATTGGGGGGAAAAAAACCCTACATGTTTCTTGTAAAGGCGTCTGACAGTCCTGAGAATTATTGATGGTAAGGAATAAAAAATGTA CAGATGACTCAGTGAAGAAACTGAGGCTTCTCTTATGAAACAAACATTGATAAACGTAACTACTAAATGTTTATGCCTCTGTAAACCAAA TTTCTTTTCTAGATAAAAATATGTATTACTACCTGCAAATTTTCTTCTGGCTGTTTTAGTAGTATTTTTTTTACAGAACTAAATATAGAG TTTGTATGATTAGTAATATTTCCTGTCCTACAGCTTTTTTTTTTTTTTTTTTTTTTTGTAAAGTATTCTGCATTGTAAAAGAAGAGAGAA AAAAAGTATTTCTGAGTTTTGGTTCAGATACAAAAGGCTTTATTTCCTGTATGGAAACAGTGATGTCCCCAGTGAATCCTTTCAGCATAA AGGAAGCAGTTATATTAAATTGGCTTCATGACAATTTGCACTCCACAAGCCTCCAGAACCTTGAGCATAAACCAGTATCATTTTTTGTAC TTCAGTCTTGCTTTTTGAGTAGTTGGCCTTAATACAGAGTATCTTTTAAAATCTCTTGTTTAGGCCGGCATGACGGCTCACACCTGTAAT CCCAGCACCTTGGGAGGCTAAGGCGGGTGGATCACTGGAGGTCAGGAGTTTGACACCAGCCTGACCAACATGGTGAAACCTTGTCTCTAC TAAAAATACAAAAATTAGTCAGGCGTGGTGGCACATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGG GAGGCAGAGGCTGCAGTGAGCCGAGATTGCACCATTGCACTCCATCCAGCCTGGGTGACAAGAGTGAAACTTCGTCTCAAAAAAAAAAAA AAAAAACAAAACTCAATGATGTAGGGACTGTTATTATTCCCATTTTACAGATGACTTGTCCAAGATCACATGAGTAGTAAGTAGCAAAGC CAGAATTCAAGTTCAGGTAAACCTGACTTCTTAGTGGGGCCAGTTTCACGGGTGTGTGGCCTGTGCAGTCACACAGAGTTCTGCACTGAA GAGGGCCTCCACTTGGTTTAATGTTCTGCTGTGACTCTCTTGAACTTCTGAATATTTTTTTAAACAATGAACTTATATTTTAGACCCTCT GAATTCTTTCGCTGGTCCTGCTTGAGACTGTGTTTCTAGTGGTGCCATGTCTACTGGAATAGAAGTACAATAGTTAGTGCAGTGCCTGGC CCAGGAGCTCCTCAAAAACAGGAATTCCATTTCCTTCCCTCTAACCTCTGCTTCTTTAACAAAGCAGCCAAAAAAAAAAAAAACAAAACA AAATAAAAAACAGAAAAGAGAAGATTCTCTCCTGTAGTATATATAGGTTTTTTCCTCTTAAATCTTTTGCTTTATAAGTATGATATAAAT CTAATAAATAGTGATTAGTGAAGTGATTGAATTTTTGTGAAAAGAGACATGATTATCCACGATCATGTAAGATTAAAATCCTGAGGCTGA TCCAGCCTTTTTTCTTTTTTTTTTTTTTAAAAAAAAAAAGCAAAAAAAACAAAAAAACTGTCTTCTCTGAATCATGTAACAGGCGCATCT GTCAGCCGGACATCTTCCTAGGTTTTTGGCTGGAGAAATGTGTAGCCGAAGGTGTCTCAGAATGGTGAGAACACTTTGCTGTCTGGATTT AGTGGGCCTGGGGCAGCCAAATGATAGTTCATTGTGCTTTGATTTTAATCCTCAAATCTCAGTCACTGGTTGCTTCCCTGGAGTATCAGA GCGTATTAGTATCATACAACCAGGGGCTGAGGTGAAATAAGCCTTGACTGTTCTAGAAAGAAAGTGATTTTTTCAGGGACAACAGCATCT GCATTTTATTGCTGTTTAAGGCTTTCTCTGCTCTGTACTTTGTTCCCTGAGTGGCACTAGGTAAATGAATGGTAAGGGAAAGTGAACTGC GTTTAGTGAATGCCTCTCTGTGCTGTGGGGCAGCTTCCCTGGGCCCCCACAGGTAATCCTGCTGCAGAGGCTTCTGTCAGGTCAGAGCTT AACAAAGATCAGACCAGAGAGAATTGTAGAAAAGATGCTATAATTTTTTCCAGAAACATATGTCCCAGATGTTTTGCAGAGCCTTAACTT AAGACAGTGGTTAGCCTGGAATGTCAGAGAAAGAATGTGTATGTGTTATATCACCAAAAGTTTAGAAATGTTATATCTTTCATAGGTTCA GGCTGCTGTGTACTCATTCAGAGCCAGGCTGAGACATGTGTTATTGCATCTTCCTGATCATTCAGATTACTCTGGTAAACAAGTGCATGC TCTGCTGTGTGTTACTGTTATGGCTAATTTGAGTCCTCAAGGTCCCATTAGCAGAGGGGGCTGGTGGCACAATTTCCCTGCTGTGCATTT CTGTGACATTCAGAAAGATAGTGCGCCAGTCCCAACTCAAACTGAAGAAGATGAGTAGCTAGCTTGTCCCTTCCAGTTTCTCTTAGAACA CTCTGAATGCAACTTTTACTGTAGGAGACTGTTCATGAAAAAATTAATTGAATCAGTCTTCAAATGAGAGGCAGGGAAACCACACATCCT GCCCACACCTACTTCCCTGGAAGATTTCTATCTACAGTCCAGCTATCCTAAAAGGTCTCAGTAGCTTGCCAGGTCAGAATGTCTAACTGT TTCAAAAAGGATGCCCAAAAATCATGACAGGAAACTTTAGCCTGGAACGAAGAGTGCTATGAAACCGTGTCAACAAGAGGAGTGGTGACA ATTGTGAGTTGAATAGCAAGATGTCCTTGCTAGGAAGGAGATGACCCAAGCTTCCCCTTATAAAAGCAACTTGGAACACATCATTCTACC TTTCAAAGATACATGGTAAGTTAAAATTGAGAAACGTACCCCTTTACTATACAGTTCCTTGGGTTGAATGAGTGCTTTTTTTTTTTTCTG AAAAGCCCCATCCCCCAAAAGGCATTTGATAGCAATGTATTAAGCACCTTTTACCAACAATAAGAACATCATTGTAAGTGTTAAAGAAAA TTGTCCTTCTCCCTACAGGTCAGCGTTTGAGCCTCACGGGGTTTCTTCCCATGACTTCAGCCCTGGCGCACAATGAGCAGACACCCAAAT CTTGTCCGCCTTCAACATTCTTTTGTTAGGGCCCATCCCTCTAGCACTCTAAAAACAAATCATCTACAACTGTGTTCCTGCTGCCCACTC ATTTTAAACATGAATTTGACATAGCTCCTCCTTTTCGCACTGGAGTAGTTAACTAATGCTAGCCCACTAGCTTCTATCATGTCCCTCAAG CAACAAACTTTGGGATCATTTTTGCTTTTTCACTCTTTCTTTACCCAATTATAATTGGTTGCCTTTTTTGTTTCATTATCCCCAGAATTT TCTCGTCTTCCTCTTCTCTCCTTGAAATTACTTTTACTGTTCCTCTCCTTTGTCATCACCTATTGATTCTGCCTTTGACTTAGTTCATAT CTACCCTTTCCTTTTCAGTCCCATAGTTACAACCTAAGCCAGCTCTTCAACAAAAATTTCTTGCTTGATGAGCAAGTTTTATTGAGGAAC TGAGGAAACACCTGTGGAAGGAACAAATGAATGATTTTGTTAATTACTTATGTTTGTCTTCAGAGACTTCCCCTCATGCTAGTTCTGTAT ACTTGTTTCACTTTTTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTTCGAGACAGTCTCGCTCCATCGCCCAGGCTGGAGTGCAGTGGTGC AATCTCACCTTACTGGCTCACTGTAACCTCTGCCTCCTGGCTTCAAGCGATTCTTGTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGC ATGCACCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTTACCATGTTGGCCAGGCTGATCTTGAACTCCCAACCTCA GGTGATCCACCCATCTTGGCCTCCCAAAGTGCTGGAATTACAGGTGTAAGCCACACGTCCGGCCCTTGTTCCACTTTTTATAATATTTAC ACCACAGAGAGGTTAAGTAATTTATTAAAGATTATAGAACTAGAAAGTGACAAAGCTCAGATTTGAACCAAGGCATTCTAGCTCCAGCCA GGCTTACCTTAATAGCTACGTTAGGTGTTTTTTTTTTTTTTTAAAGAAAAAAGAAAAAATGTCCTCAAAAGGAAATAAATGGGGTAACAG GGTACTATGACGGAGTAGAAGGTAGTTGGTGTTCTAGATAGGGAAATCAGGAAAGGCCTTTCTAAGAAAGTGGTATTTTACCTGAGTTCC AAAGGATAATGCCTTAAATATTTGTCCTCCTTCTACTTCACTCCCAACTTAGATTTTGCCCCACCCACAAAGTCTTTGTCTTCATTTAGC TTGAGCAAATTCTCTAAATAACTCTGTGACATAGCCACCCATACCAAAGGTTAGTGCTGAGTTATATACCATCGAATTGCAGTCCTTGTT CTTAGAAACACCTGTGGAAGGAATAATGAATGCTATTGCTGATTATTTATGTTTGTCTTCAGGGACTGTACCTCATTCTAGTTTTGTATC CTTGTTCCACTTTTGATAGTATTTACACCACAGCTCTGTACAAAACATAGGCACTAATTAAATACATAAATTATTTGGCCAGGCATGGTG GCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGTATCACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAAGATGGTGAA ACCCCATCTCTACTAAAAATACAAAAAATTTGCCGGCGTGGTGGCGGGCGCCTGTAATTCCAGCTACTTGGGAGGCTGAGGCAAATAATT GCTTGAACCAGGGAGGTGGAGGTTGCAGTGAACTGAGATGGCACCACTGCACTCCAGCCTGGGGGACAGAGCGAGACTCCACCTCAAAAA AAAAAAAAGAAAAAAATTATAGCTTCAGACTTGTCTAGGCTCACTTCAGTTATATTTTATCTAGACCAGTGCTTCACAAACGTTTTGATC TCAGGACCTCATTATACTAAAAAATTATTGAAAACTGGCTGGGCACAGTGTTTCACACTTGTAATCCCAGCACTTTGGGAGGCCGAGGTG GATGGATCACCTGAGCCCAGGAGTTTGAGATCAGCCTGGGCAACACAGTAAAACCCCATCTCTACAAAAAAAATACAAAAATTAGCCAGG CATGGTGATGCACACCTATAGTTCCAGCTACTTGGGAGGCTGAGGTGGTAGGATCACTTGAGCCTGGGAGGTGGAGGTTGCAGTGAGCCG AGATCATGGCACTGCACTCCAGCCTGGGTGACAGAGTGAGACCCTGCCTCAGAAAAAAAAAAAATATATCCCAATGAGCTTTTGTTTGTG TGAGCTATATTTGTCAATATTTACCATTGTAGAAACTAGACAAAAATTTTAAACGCAAGAATATAAAAGGACATATTCCACTGGCTGTCA GAACAATATCATCACACATCTTGTAGCATCTGGAAAACTATACCATCATAAGAATGACAAGGAAAAGGCAAATAACATCTTAATATTACT ATGAAAATAGTTTTGACCTCATAAACCCCTAAAAACGTCTTGAAGACTCCCCAGGACCTTGGACCACATTTTAAGAACTGCTGCTTTACA TAATGTCACATCAGCGAATTCATCTCTTCTTTTTTTAAAATAAGAGGCAGGGTTTCACTATGTTGTCCAGACTGGTCTCAAACTCCTGGT CTCAAGGAATCCTCCTATCTTGGCCTTCCAAAGTGCTGGAATCACAGGCATGCGGCACTGCGCCCGGCCTATCTCCTCTTTAGTCAGTCA GTGATCTGTGTATTAGTTTTATCGCTGTGTAAAAAATTGCCACACATATATTGGCTTAAAACAATACATTATCTCTGTAGGTTAGAAATC CAGGCAAAGAAGGTTTTCTGCTCAAGATCTCAAAAGGCTGAAATCAAGATGATGGCCAAGGCTGAGTTCTGATCTGCAACTCTGAATCCT TTTCAGATACCTTCAGATGGTTGTTGGCAGAATTCAGTTCCTTGCAGTTGTAGGATTTGTGGTGGCCTGCTTCCTATCTTTTAAGGACTC ACATGACTGAGTCAGTGTAATCTCCCTTTTGATTAATTCAAGGTCAACTGATTAGGATCATAATTACGTCCCTTTTGCCATGTTAATGTA ACATAATCAGAGGAATGACATGTCATGATATTCACAGATCCCACCCATACTAACGGATAGTAGATTATCCAGGGCATGTAAATCAGGGGG TGGAATATTAGGGGACATCTTTTTTTTTTTTCTTTAAGACGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCTGTGGTGCAATCTCAACT CACTGCAACCTCTACCTCCCTGGTTCAAGCGATTCTCGTGCCTCAGCCGCCTGACTAGCTGGGATTTCAGGAGTGCACCACCAGCCCGGC TAACTTTTGTATTTTTAGCAGAGATGGGGTTTCACCATGTTGGCCGGGCTGGTCTCGAACTCCTGGGCTCAAGTGATCCGCCCACCTCGG CTTCCCAAAGTGCTGGAATTACAGGCGTCAGCCACCATGCCCGTTCTGGGGGCCATCTGAGACTTCTGCCAACCACAATCAGCTAGATGT TTTTTGTTTTGTTTTGAAAAAATAATAATAATAACCTTTCACTTGGGCCACCAAACTCCTACCTTAGTATCCAAGTTCTCTAATTTTTTT TTAATATGGGAAATCCACATCTCCCAAACTCTATCCCTTTTCTGGCAAGTTACTTGACCTTTCTGTAAAATAAGCATAATGTACCTGCGT TAGAGTTGTAGGGAGCACTAAACATTCAGATGATGTATGTACAGTGTTTAGCACAGAGCCTGCTAAATAGTAAGCCCTCAAGCCCTCAGT CACATTTGTCTCCATCAGTGGTAGCTCCCCTGGTGTGTTAAGGAGGCTCTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGT CTCGCTCTGTTGCCCAGGCTGAAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTGTCCTGCCTCA GCCTCCCGAGTAGCTGGGATTACAGGCGCCTGTCACCACGCCCGGCTAATTTTTTTTTTGTTTGTTTTTTTTGTATTTTTAGTAGAGACA GGGTTTCACTGTGTTAGCCAGGATGGTCTCCATCTCCTCACCTCGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGT GAGCCACTGCGCCCGGCCAGGAGGCTCTTTTTAAACTAAGGGCAGCAACCCCCTAGGGTGGCTATAGTCCAAGAAAACCCAGAAAATACA TGCTGCCAAGGATTTGGAGAAATTGGAGCCCTCCTACATTGCTGGTAGGAATGTAGAATGGTGCAGCAGCTGTGGAAAACAGTTCAGCAG TTTCACAAAAATCAAACATAGGGTTATCATATGACCCAGAAATTCTACCCATAGGTGTATACCCTGGAGAATTAAAAACATGTATTTACA CAAAAACTTATATGTTCGCAGCAGCGTTATTCATAATAACCCGAAAGTAGAAACAACCCAAATGCTCTACTAATGAACAGATAAACAAAA TGTGGTATATCCATATAGTGGAATATTACTCGATCACACAAAGGAATGAAGTACTAATACATGCTACAGTGTGGATGAACCTTGTAAACA GTAGGCTAAGTTACAGAAGCCAGCCACAAAAGACAACAAATGCATGATTCTATTCATATGAAATGTCCAGAGTAGGCAAGTCCATAGACA GAAAGTAGCTTAGTGGTTTCCAGGGGCAGTGAGAAGGGGAAATGGAGGGCAACTCCTAATGGGTATGAGGCTTCTTTTGGAGGTGATGAA AATGTTCTGGAATTCGACAGTGGTGATGGTTGTACATCTCTGTGAATATACTAAAAGCCACTGAATTGTATACTGGGTGAATTTTATGGT ATCTGTAGACATTCCAATTGACAGTCACATCTTAGTATAGACTTTGAGTCATCTCACTGGAGGCACTAGACATGCAAGAGGAGAAGTCTC CAGATTATTCCAGCCCTGCCATTTGAGTCACTCCAGGCTTTCTGGTCTTCCCAGCTGAGGCTCAGACACCTTGGAAGAGAGAAAAGCTCT CCCTTCTGTGCCCTGTGATTTGCTGATCCACAGAGTTCATAGGCATGATTAAATGGTAGTAGTTTTCCACCACGAAGTTTTGGAATAATT TGTCACAAAGCAATAGGTAATTAGAAAAATAACCTTTCAGAAGGAGACAGTTTCTCCAAAGCTTGGGTACTTTCGCTTAATATTAAAAGA GGAAGAAATTTTTTGCCTGCCAGGCAAAAGGCAGAAGATGTATTTCTACACCATGGATAGGAAAATGATTTTTTTTCCTCCTTTCTCCTT GGCCTGCATGCAGCAGTGAAAAAGAAACCAATGGATTCTTTTAAATCTTTAACCATATGCAGATGAATAAGCACATGGTTGGACTTGATT >13274_13274_1_CASZ1-ALG14_CASZ1_chr1_10753931_ENST00000344008_ALG14_chr1_95530573_ENST00000370205_length(amino acids)=187AA_BP=16 MLREFGTKEKRMDLGTGGHTTEILRLLGSLSNAYSPRHYVIADTDEMSANKINSFELDRADRDPSNMYTKYYIHRIPRSREVQQSWPSTV FTTLHSMWLSFPLIHRVKPDLVLCNGPGTCVPICVSALLLGILGIKKVIIVYVESICRVETLSMSGKILFHLSDYFIVQWPALKEKYPKS -------------------------------------------------------------- >13274_13274_2_CASZ1-ALG14_CASZ1_chr1_10753931_ENST00000377022_ALG14_chr1_95530573_ENST00000370205_length(transcript)=9518nt_BP=334nt ATGCGCGCCCGCGGCGCTCCATCCCAAACACACACACATTTTTCCCCCGGACTTGGAAAGTCACCCAAAGCCGCCCCAAGTGCAGGCAAA CAGACCTTGCTGACTGAAGGCAAAGACTCCTCCATCCCACCTGCCCTCCCAGCTGCCACGGCCATCGACCCCTCCTTTACAAGGGGCTCC TGCAACTCCCCAGCAGCACGTGTTGGAATGGACTTCGGACCCTGGCCTCTTGGGATGCAAAGGATGAAGTGACACCCCCAGCTACATCCG AGGAGGTTCTAGGACCTGCTACGAGAGTTTGGGACCAAGGAGAAGAGAATGGATCTTGGAACAGGTGGGCATACCACTGAGATCCTGAGG CTGCTTGGGAGCTTGTCCAATGCCTACTCACCTAGACATTATGTCATTGCTGACACTGATGAAATGAGTGCCAATAAAATAAATTCTTTT GAACTAGATCGAGCTGATAGAGACCCTAGTAACATGTATACCAAATACTACATTCACCGAATTCCAAGAAGCCGGGAGGTTCAGCAGTCC TGGCCCTCCACCGTTTTCACCACCTTGCACTCCATGTGGCTCTCCTTTCCCCTAATTCACAGGGTGAAGCCAGATTTGGTGTTGTGTAAC GGACCAGGAACATGTGTTCCTATCTGTGTATCTGCCCTTCTCCTTGGGATACTAGGAATAAAGAAAGTGATCATTGTCTACGTTGAAAGC ATCTGCCGTGTAGAAACGTTATCCATGTCCGGAAAGATTCTGTTTCATCTCTCAGATTACTTCATTGTTCAGTGGCCGGCTCTGAAAGAA AAGTATCCCAAATCGGTGTACCTTGGGCGAATTGTTTGACAAATGGCAACTGACTTCTTTAGAATTTTGCAGTTAACAGTAGTATGTACT CAAATTGGGGGGAAAAAAACCCTACATGTTTCTTGTAAAGGCGTCTGACAGTCCTGAGAATTATTGATGGTAAGGAATAAAAAATGTACA GATGACTCAGTGAAGAAACTGAGGCTTCTCTTATGAAACAAACATTGATAAACGTAACTACTAAATGTTTATGCCTCTGTAAACCAAATT TCTTTTCTAGATAAAAATATGTATTACTACCTGCAAATTTTCTTCTGGCTGTTTTAGTAGTATTTTTTTTACAGAACTAAATATAGAGTT TGTATGATTAGTAATATTTCCTGTCCTACAGCTTTTTTTTTTTTTTTTTTTTTTTGTAAAGTATTCTGCATTGTAAAAGAAGAGAGAAAA AAAGTATTTCTGAGTTTTGGTTCAGATACAAAAGGCTTTATTTCCTGTATGGAAACAGTGATGTCCCCAGTGAATCCTTTCAGCATAAAG GAAGCAGTTATATTAAATTGGCTTCATGACAATTTGCACTCCACAAGCCTCCAGAACCTTGAGCATAAACCAGTATCATTTTTTGTACTT CAGTCTTGCTTTTTGAGTAGTTGGCCTTAATACAGAGTATCTTTTAAAATCTCTTGTTTAGGCCGGCATGACGGCTCACACCTGTAATCC CAGCACCTTGGGAGGCTAAGGCGGGTGGATCACTGGAGGTCAGGAGTTTGACACCAGCCTGACCAACATGGTGAAACCTTGTCTCTACTA AAAATACAAAAATTAGTCAGGCGTGGTGGCACATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGA GGCAGAGGCTGCAGTGAGCCGAGATTGCACCATTGCACTCCATCCAGCCTGGGTGACAAGAGTGAAACTTCGTCTCAAAAAAAAAAAAAA AAAACAAAACTCAATGATGTAGGGACTGTTATTATTCCCATTTTACAGATGACTTGTCCAAGATCACATGAGTAGTAAGTAGCAAAGCCA GAATTCAAGTTCAGGTAAACCTGACTTCTTAGTGGGGCCAGTTTCACGGGTGTGTGGCCTGTGCAGTCACACAGAGTTCTGCACTGAAGA GGGCCTCCACTTGGTTTAATGTTCTGCTGTGACTCTCTTGAACTTCTGAATATTTTTTTAAACAATGAACTTATATTTTAGACCCTCTGA ATTCTTTCGCTGGTCCTGCTTGAGACTGTGTTTCTAGTGGTGCCATGTCTACTGGAATAGAAGTACAATAGTTAGTGCAGTGCCTGGCCC AGGAGCTCCTCAAAAACAGGAATTCCATTTCCTTCCCTCTAACCTCTGCTTCTTTAACAAAGCAGCCAAAAAAAAAAAAAACAAAACAAA ATAAAAAACAGAAAAGAGAAGATTCTCTCCTGTAGTATATATAGGTTTTTTCCTCTTAAATCTTTTGCTTTATAAGTATGATATAAATCT AATAAATAGTGATTAGTGAAGTGATTGAATTTTTGTGAAAAGAGACATGATTATCCACGATCATGTAAGATTAAAATCCTGAGGCTGATC CAGCCTTTTTTCTTTTTTTTTTTTTTAAAAAAAAAAAGCAAAAAAAACAAAAAAACTGTCTTCTCTGAATCATGTAACAGGCGCATCTGT CAGCCGGACATCTTCCTAGGTTTTTGGCTGGAGAAATGTGTAGCCGAAGGTGTCTCAGAATGGTGAGAACACTTTGCTGTCTGGATTTAG TGGGCCTGGGGCAGCCAAATGATAGTTCATTGTGCTTTGATTTTAATCCTCAAATCTCAGTCACTGGTTGCTTCCCTGGAGTATCAGAGC GTATTAGTATCATACAACCAGGGGCTGAGGTGAAATAAGCCTTGACTGTTCTAGAAAGAAAGTGATTTTTTCAGGGACAACAGCATCTGC ATTTTATTGCTGTTTAAGGCTTTCTCTGCTCTGTACTTTGTTCCCTGAGTGGCACTAGGTAAATGAATGGTAAGGGAAAGTGAACTGCGT TTAGTGAATGCCTCTCTGTGCTGTGGGGCAGCTTCCCTGGGCCCCCACAGGTAATCCTGCTGCAGAGGCTTCTGTCAGGTCAGAGCTTAA CAAAGATCAGACCAGAGAGAATTGTAGAAAAGATGCTATAATTTTTTCCAGAAACATATGTCCCAGATGTTTTGCAGAGCCTTAACTTAA GACAGTGGTTAGCCTGGAATGTCAGAGAAAGAATGTGTATGTGTTATATCACCAAAAGTTTAGAAATGTTATATCTTTCATAGGTTCAGG CTGCTGTGTACTCATTCAGAGCCAGGCTGAGACATGTGTTATTGCATCTTCCTGATCATTCAGATTACTCTGGTAAACAAGTGCATGCTC TGCTGTGTGTTACTGTTATGGCTAATTTGAGTCCTCAAGGTCCCATTAGCAGAGGGGGCTGGTGGCACAATTTCCCTGCTGTGCATTTCT GTGACATTCAGAAAGATAGTGCGCCAGTCCCAACTCAAACTGAAGAAGATGAGTAGCTAGCTTGTCCCTTCCAGTTTCTCTTAGAACACT CTGAATGCAACTTTTACTGTAGGAGACTGTTCATGAAAAAATTAATTGAATCAGTCTTCAAATGAGAGGCAGGGAAACCACACATCCTGC CCACACCTACTTCCCTGGAAGATTTCTATCTACAGTCCAGCTATCCTAAAAGGTCTCAGTAGCTTGCCAGGTCAGAATGTCTAACTGTTT CAAAAAGGATGCCCAAAAATCATGACAGGAAACTTTAGCCTGGAACGAAGAGTGCTATGAAACCGTGTCAACAAGAGGAGTGGTGACAAT TGTGAGTTGAATAGCAAGATGTCCTTGCTAGGAAGGAGATGACCCAAGCTTCCCCTTATAAAAGCAACTTGGAACACATCATTCTACCTT TCAAAGATACATGGTAAGTTAAAATTGAGAAACGTACCCCTTTACTATACAGTTCCTTGGGTTGAATGAGTGCTTTTTTTTTTTTCTGAA AAGCCCCATCCCCCAAAAGGCATTTGATAGCAATGTATTAAGCACCTTTTACCAACAATAAGAACATCATTGTAAGTGTTAAAGAAAATT GTCCTTCTCCCTACAGGTCAGCGTTTGAGCCTCACGGGGTTTCTTCCCATGACTTCAGCCCTGGCGCACAATGAGCAGACACCCAAATCT TGTCCGCCTTCAACATTCTTTTGTTAGGGCCCATCCCTCTAGCACTCTAAAAACAAATCATCTACAACTGTGTTCCTGCTGCCCACTCAT TTTAAACATGAATTTGACATAGCTCCTCCTTTTCGCACTGGAGTAGTTAACTAATGCTAGCCCACTAGCTTCTATCATGTCCCTCAAGCA ACAAACTTTGGGATCATTTTTGCTTTTTCACTCTTTCTTTACCCAATTATAATTGGTTGCCTTTTTTGTTTCATTATCCCCAGAATTTTC TCGTCTTCCTCTTCTCTCCTTGAAATTACTTTTACTGTTCCTCTCCTTTGTCATCACCTATTGATTCTGCCTTTGACTTAGTTCATATCT ACCCTTTCCTTTTCAGTCCCATAGTTACAACCTAAGCCAGCTCTTCAACAAAAATTTCTTGCTTGATGAGCAAGTTTTATTGAGGAACTG AGGAAACACCTGTGGAAGGAACAAATGAATGATTTTGTTAATTACTTATGTTTGTCTTCAGAGACTTCCCCTCATGCTAGTTCTGTATAC TTGTTTCACTTTTTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTTCGAGACAGTCTCGCTCCATCGCCCAGGCTGGAGTGCAGTGGTGCAA TCTCACCTTACTGGCTCACTGTAACCTCTGCCTCCTGGCTTCAAGCGATTCTTGTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCAT GCACCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTTACCATGTTGGCCAGGCTGATCTTGAACTCCCAACCTCAGG TGATCCACCCATCTTGGCCTCCCAAAGTGCTGGAATTACAGGTGTAAGCCACACGTCCGGCCCTTGTTCCACTTTTTATAATATTTACAC CACAGAGAGGTTAAGTAATTTATTAAAGATTATAGAACTAGAAAGTGACAAAGCTCAGATTTGAACCAAGGCATTCTAGCTCCAGCCAGG CTTACCTTAATAGCTACGTTAGGTGTTTTTTTTTTTTTTTAAAGAAAAAAGAAAAAATGTCCTCAAAAGGAAATAAATGGGGTAACAGGG TACTATGACGGAGTAGAAGGTAGTTGGTGTTCTAGATAGGGAAATCAGGAAAGGCCTTTCTAAGAAAGTGGTATTTTACCTGAGTTCCAA AGGATAATGCCTTAAATATTTGTCCTCCTTCTACTTCACTCCCAACTTAGATTTTGCCCCACCCACAAAGTCTTTGTCTTCATTTAGCTT GAGCAAATTCTCTAAATAACTCTGTGACATAGCCACCCATACCAAAGGTTAGTGCTGAGTTATATACCATCGAATTGCAGTCCTTGTTCT TAGAAACACCTGTGGAAGGAATAATGAATGCTATTGCTGATTATTTATGTTTGTCTTCAGGGACTGTACCTCATTCTAGTTTTGTATCCT TGTTCCACTTTTGATAGTATTTACACCACAGCTCTGTACAAAACATAGGCACTAATTAAATACATAAATTATTTGGCCAGGCATGGTGGC TCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGTATCACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAAGATGGTGAAAC CCCATCTCTACTAAAAATACAAAAAATTTGCCGGCGTGGTGGCGGGCGCCTGTAATTCCAGCTACTTGGGAGGCTGAGGCAAATAATTGC TTGAACCAGGGAGGTGGAGGTTGCAGTGAACTGAGATGGCACCACTGCACTCCAGCCTGGGGGACAGAGCGAGACTCCACCTCAAAAAAA AAAAAAGAAAAAAATTATAGCTTCAGACTTGTCTAGGCTCACTTCAGTTATATTTTATCTAGACCAGTGCTTCACAAACGTTTTGATCTC AGGACCTCATTATACTAAAAAATTATTGAAAACTGGCTGGGCACAGTGTTTCACACTTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGA TGGATCACCTGAGCCCAGGAGTTTGAGATCAGCCTGGGCAACACAGTAAAACCCCATCTCTACAAAAAAAATACAAAAATTAGCCAGGCA TGGTGATGCACACCTATAGTTCCAGCTACTTGGGAGGCTGAGGTGGTAGGATCACTTGAGCCTGGGAGGTGGAGGTTGCAGTGAGCCGAG ATCATGGCACTGCACTCCAGCCTGGGTGACAGAGTGAGACCCTGCCTCAGAAAAAAAAAAAATATATCCCAATGAGCTTTTGTTTGTGTG AGCTATATTTGTCAATATTTACCATTGTAGAAACTAGACAAAAATTTTAAACGCAAGAATATAAAAGGACATATTCCACTGGCTGTCAGA ACAATATCATCACACATCTTGTAGCATCTGGAAAACTATACCATCATAAGAATGACAAGGAAAAGGCAAATAACATCTTAATATTACTAT GAAAATAGTTTTGACCTCATAAACCCCTAAAAACGTCTTGAAGACTCCCCAGGACCTTGGACCACATTTTAAGAACTGCTGCTTTACATA ATGTCACATCAGCGAATTCATCTCTTCTTTTTTTAAAATAAGAGGCAGGGTTTCACTATGTTGTCCAGACTGGTCTCAAACTCCTGGTCT CAAGGAATCCTCCTATCTTGGCCTTCCAAAGTGCTGGAATCACAGGCATGCGGCACTGCGCCCGGCCTATCTCCTCTTTAGTCAGTCAGT GATCTGTGTATTAGTTTTATCGCTGTGTAAAAAATTGCCACACATATATTGGCTTAAAACAATACATTATCTCTGTAGGTTAGAAATCCA GGCAAAGAAGGTTTTCTGCTCAAGATCTCAAAAGGCTGAAATCAAGATGATGGCCAAGGCTGAGTTCTGATCTGCAACTCTGAATCCTTT TCAGATACCTTCAGATGGTTGTTGGCAGAATTCAGTTCCTTGCAGTTGTAGGATTTGTGGTGGCCTGCTTCCTATCTTTTAAGGACTCAC ATGACTGAGTCAGTGTAATCTCCCTTTTGATTAATTCAAGGTCAACTGATTAGGATCATAATTACGTCCCTTTTGCCATGTTAATGTAAC ATAATCAGAGGAATGACATGTCATGATATTCACAGATCCCACCCATACTAACGGATAGTAGATTATCCAGGGCATGTAAATCAGGGGGTG GAATATTAGGGGACATCTTTTTTTTTTTTCTTTAAGACGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCTGTGGTGCAATCTCAACTCA CTGCAACCTCTACCTCCCTGGTTCAAGCGATTCTCGTGCCTCAGCCGCCTGACTAGCTGGGATTTCAGGAGTGCACCACCAGCCCGGCTA ACTTTTGTATTTTTAGCAGAGATGGGGTTTCACCATGTTGGCCGGGCTGGTCTCGAACTCCTGGGCTCAAGTGATCCGCCCACCTCGGCT TCCCAAAGTGCTGGAATTACAGGCGTCAGCCACCATGCCCGTTCTGGGGGCCATCTGAGACTTCTGCCAACCACAATCAGCTAGATGTTT TTTGTTTTGTTTTGAAAAAATAATAATAATAACCTTTCACTTGGGCCACCAAACTCCTACCTTAGTATCCAAGTTCTCTAATTTTTTTTT AATATGGGAAATCCACATCTCCCAAACTCTATCCCTTTTCTGGCAAGTTACTTGACCTTTCTGTAAAATAAGCATAATGTACCTGCGTTA GAGTTGTAGGGAGCACTAAACATTCAGATGATGTATGTACAGTGTTTAGCACAGAGCCTGCTAAATAGTAAGCCCTCAAGCCCTCAGTCA CATTTGTCTCCATCAGTGGTAGCTCCCCTGGTGTGTTAAGGAGGCTCTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCT CGCTCTGTTGCCCAGGCTGAAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTGTCCTGCCTCAGC CTCCCGAGTAGCTGGGATTACAGGCGCCTGTCACCACGCCCGGCTAATTTTTTTTTTGTTTGTTTTTTTTGTATTTTTAGTAGAGACAGG GTTTCACTGTGTTAGCCAGGATGGTCTCCATCTCCTCACCTCGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGA GCCACTGCGCCCGGCCAGGAGGCTCTTTTTAAACTAAGGGCAGCAACCCCCTAGGGTGGCTATAGTCCAAGAAAACCCAGAAAATACATG CTGCCAAGGATTTGGAGAAATTGGAGCCCTCCTACATTGCTGGTAGGAATGTAGAATGGTGCAGCAGCTGTGGAAAACAGTTCAGCAGTT TCACAAAAATCAAACATAGGGTTATCATATGACCCAGAAATTCTACCCATAGGTGTATACCCTGGAGAATTAAAAACATGTATTTACACA AAAACTTATATGTTCGCAGCAGCGTTATTCATAATAACCCGAAAGTAGAAACAACCCAAATGCTCTACTAATGAACAGATAAACAAAATG TGGTATATCCATATAGTGGAATATTACTCGATCACACAAAGGAATGAAGTACTAATACATGCTACAGTGTGGATGAACCTTGTAAACAGT AGGCTAAGTTACAGAAGCCAGCCACAAAAGACAACAAATGCATGATTCTATTCATATGAAATGTCCAGAGTAGGCAAGTCCATAGACAGA AAGTAGCTTAGTGGTTTCCAGGGGCAGTGAGAAGGGGAAATGGAGGGCAACTCCTAATGGGTATGAGGCTTCTTTTGGAGGTGATGAAAA TGTTCTGGAATTCGACAGTGGTGATGGTTGTACATCTCTGTGAATATACTAAAAGCCACTGAATTGTATACTGGGTGAATTTTATGGTAT CTGTAGACATTCCAATTGACAGTCACATCTTAGTATAGACTTTGAGTCATCTCACTGGAGGCACTAGACATGCAAGAGGAGAAGTCTCCA GATTATTCCAGCCCTGCCATTTGAGTCACTCCAGGCTTTCTGGTCTTCCCAGCTGAGGCTCAGACACCTTGGAAGAGAGAAAAGCTCTCC CTTCTGTGCCCTGTGATTTGCTGATCCACAGAGTTCATAGGCATGATTAAATGGTAGTAGTTTTCCACCACGAAGTTTTGGAATAATTTG TCACAAAGCAATAGGTAATTAGAAAAATAACCTTTCAGAAGGAGACAGTTTCTCCAAAGCTTGGGTACTTTCGCTTAATATTAAAAGAGG AAGAAATTTTTTGCCTGCCAGGCAAAAGGCAGAAGATGTATTTCTACACCATGGATAGGAAAATGATTTTTTTTCCTCCTTTCTCCTTGG CCTGCATGCAGCAGTGAAAAAGAAACCAATGGATTCTTTTAAATCTTTAACCATATGCAGATGAATAAGCACATGGTTGGACTTGATTCC >13274_13274_2_CASZ1-ALG14_CASZ1_chr1_10753931_ENST00000377022_ALG14_chr1_95530573_ENST00000370205_length(amino acids)=187AA_BP=16 MLREFGTKEKRMDLGTGGHTTEILRLLGSLSNAYSPRHYVIADTDEMSANKINSFELDRADRDPSNMYTKYYIHRIPRSREVQQSWPSTV FTTLHSMWLSFPLIHRVKPDLVLCNGPGTCVPICVSALLLGILGIKKVIIVYVESICRVETLSMSGKILFHLSDYFIVQWPALKEKYPKS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CASZ1-ALG14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CASZ1-ALG14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CASZ1-ALG14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CASZ1 | C0004238 | Atrial Fibrillation | 2 | CTD_human |
| Hgene | CASZ1 | C0235480 | Paroxysmal atrial fibrillation | 2 | CTD_human |
| Hgene | CASZ1 | C2585653 | Persistent atrial fibrillation | 2 | CTD_human |
| Hgene | CASZ1 | C3468561 | familial atrial fibrillation | 2 | CTD_human |
| Hgene | CASZ1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | CASZ1 | C0038454 | Cerebrovascular accident | 1 | CTD_human |
| Hgene | CASZ1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| Hgene | CASZ1 | C0751956 | Acute Cerebrovascular Accidents | 1 | CTD_human |
| Tgene | C4015596 | MYASTHENIC SYNDROME, CONGENITAL, 15 | 3 | GENOMICS_ENGLAND;UNIPROT | |
| Tgene | C0751882 | Myasthenic Syndromes, Congenital | 1 | CTD_human;GENOMICS_ENGLAND | |
| Tgene | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
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