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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CDKAL1-KCNMB2 (FusionGDB2 ID:HG54901TG10242) |
Fusion Gene Summary for CDKAL1-KCNMB2 |
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Fusion gene information | Fusion gene name: CDKAL1-KCNMB2 | Fusion gene ID: hg54901tg10242 | Hgene | Tgene | Gene symbol | CDKAL1 | KCNMB2 | Gene ID | 54901 | 10242 |
Gene name | CDK5 regulatory subunit associated protein 1 like 1 | potassium calcium-activated channel subfamily M regulatory beta subunit 2 | |
Synonyms | - | - | |
Cytomap | ('CDKAL1')('KCNMB2') 6p22.3 | 3q26.32 | |
Type of gene | protein-coding | protein-coding | |
Description | threonylcarbamoyladenosine tRNA methylthiotransferasetRNA-t(6)A37 methylthiotransferase | calcium-activated potassium channel subunit beta-2BK channel beta subunit 2BK channel subunit beta-2MaxiK channel beta 2 subunitMaxiK channel beta-subunit 2big potassium channel beta subunit 2charybdotoxin receptor subunit beta-2hCG1646471hbeta2k | |
Modification date | 20200322 | 20200313 | |
UniProtAcc | Q5VV42 | Q9Y691 | |
Ensembl transtripts involved in fusion gene | ENST00000274695, ENST00000378610, ENST00000378624, ENST00000476517, | ||
Fusion gene scores | * DoF score | 37 X 20 X 14=10360 | 5 X 3 X 5=75 |
# samples | 39 | 5 | |
** MAII score | log2(39/10360*10)=-4.73140606882431 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CDKAL1 [Title/Abstract] AND KCNMB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CDKAL1(20649608)-KCNMB2(178525131), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | KCNMB2 | GO:0001508 | action potential | 10692449 |
Tgene | KCNMB2 | GO:0005513 | detection of calcium ion | 10692449 |
Tgene | KCNMB2 | GO:0006813 | potassium ion transport | 10692449 |
Tgene | KCNMB2 | GO:0019228 | neuronal action potential | 10692449 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | HNSC | TCGA-BA-A4II-01A | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
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Fusion Gene ORF analysis for CDKAL1-KCNMB2 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000274695 | ENST00000470361 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
5CDS-3UTR | ENST00000378610 | ENST00000470361 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
5CDS-3UTR | ENST00000378624 | ENST00000470361 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
5CDS-5UTR | ENST00000274695 | ENST00000358316 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
5CDS-5UTR | ENST00000274695 | ENST00000420517 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
5CDS-5UTR | ENST00000274695 | ENST00000432997 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
5CDS-5UTR | ENST00000274695 | ENST00000452583 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
5CDS-5UTR | ENST00000378610 | ENST00000358316 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
5CDS-5UTR | ENST00000378610 | ENST00000420517 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
5CDS-5UTR | ENST00000378610 | ENST00000432997 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
5CDS-5UTR | ENST00000378610 | ENST00000452583 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
5CDS-5UTR | ENST00000378624 | ENST00000358316 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
5CDS-5UTR | ENST00000378624 | ENST00000420517 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
5CDS-5UTR | ENST00000378624 | ENST00000432997 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
5CDS-5UTR | ENST00000378624 | ENST00000452583 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
intron-3UTR | ENST00000476517 | ENST00000470361 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
intron-5UTR | ENST00000476517 | ENST00000358316 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
intron-5UTR | ENST00000476517 | ENST00000420517 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
intron-5UTR | ENST00000476517 | ENST00000432997 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
intron-5UTR | ENST00000476517 | ENST00000452583 | CDKAL1 | chr6 | 20649608 | - | KCNMB2 | chr3 | 178525131 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CDKAL1-KCNMB2 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CDKAL1-KCNMB2 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:20649608/:178525131) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CDKAL1 | KCNMB2 |
FUNCTION: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. {ECO:0000250|UniProtKB:Q91WE6}. | FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. {ECO:0000269|PubMed:10097176, ECO:0000269|PubMed:10377337}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CDKAL1-KCNMB2 |
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Fusion Gene PPI Analysis for CDKAL1-KCNMB2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CDKAL1-KCNMB2 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CDKAL1-KCNMB2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CDKAL1 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 3 | CTD_human |
Hgene | CDKAL1 | C0005910 | Body Weight | 2 | CTD_human |
Hgene | CDKAL1 | C0005612 | Birth Weight | 1 | CTD_human |
Hgene | CDKAL1 | C0263859 | Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome | 1 | CTD_human |