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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDKAL1-FARS2 (FusionGDB2 ID:HG54901TG10667)

Fusion Gene Summary for CDKAL1-FARS2

check button Fusion gene summary
Fusion gene informationFusion gene name: CDKAL1-FARS2
Fusion gene ID: hg54901tg10667
HgeneTgene
Gene symbol

CDKAL1

FARS2

Gene ID

54901

10667

Gene nameCDK5 regulatory subunit associated protein 1 like 1phenylalanyl-tRNA synthetase 2, mitochondrial
Synonyms-COXPD14|FARS1|HSPC320|PheRS|SPG77|mtPheRS
Cytomap('CDKAL1')('FARS2')

6p22.3

6p25.1

Type of geneprotein-codingprotein-coding
Descriptionthreonylcarbamoyladenosine tRNA methylthiotransferasetRNA-t(6)A37 methylthiotransferasephenylalanine--tRNA ligase, mitochondrialdJ236A3.1 (phenylalanine-tRNA synthetase)dJ520B18.2 (FARS1 (phenylalanine-tRNA synthetase))mitochondrial PHERSphenylalanine tRNA ligase 2, mitochondrialphenylalanine translasephenylalanine-tRNA synthetase 1 (
Modification date2020032220200313
UniProtAcc

Q5VV42

.
Ensembl transtripts involved in fusion geneENST00000274695, ENST00000378610, 
ENST00000378624, ENST00000476517, 
Fusion gene scores* DoF score37 X 20 X 14=1036015 X 13 X 10=1950
# samples 3921
** MAII scorelog2(39/10360*10)=-4.73140606882431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(21/1950*10)=-3.21501289097085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDKAL1 [Title/Abstract] AND FARS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDKAL1(21065459)-FARS2(5771524), # samples:1
Anticipated loss of major functional domain due to fusion event.CDKAL1-FARS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKAL1-FARS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKAL1-FARS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKAL1-FARS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKAL1-FARS2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFARS2

GO:0006432

phenylalanyl-tRNA aminoacylation

10329163

TgeneFARS2

GO:0008033

tRNA processing

10329163


check buttonFusion gene breakpoints across CDKAL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FARS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-AA68-01ACDKAL1chr6

21065459

+FARS2chr6

5771524

+


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Fusion Gene ORF analysis for CDKAL1-FARS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000274695ENST00000274680CDKAL1chr6

21065459

+FARS2chr6

5771524

+
Frame-shiftENST00000378610ENST00000274680CDKAL1chr6

21065459

+FARS2chr6

5771524

+
Frame-shiftENST00000378624ENST00000274680CDKAL1chr6

21065459

+FARS2chr6

5771524

+
In-frameENST00000274695ENST00000324331CDKAL1chr6

21065459

+FARS2chr6

5771524

+
In-frameENST00000378610ENST00000324331CDKAL1chr6

21065459

+FARS2chr6

5771524

+
In-frameENST00000378624ENST00000324331CDKAL1chr6

21065459

+FARS2chr6

5771524

+
intron-3CDSENST00000476517ENST00000274680CDKAL1chr6

21065459

+FARS2chr6

5771524

+
intron-3CDSENST00000476517ENST00000324331CDKAL1chr6

21065459

+FARS2chr6

5771524

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000274695CDKAL1chr621065459+ENST00000324331FARS2chr65771524+154214031671540458
ENST00000378624CDKAL1chr621065459+ENST00000324331FARS2chr65771524+142912902641427388
ENST00000378610CDKAL1chr621065459+ENST00000324331FARS2chr65771524+13851246101383458

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000274695ENST00000324331CDKAL1chr621065459+FARS2chr65771524+0.25822670.74177337
ENST00000378624ENST00000324331CDKAL1chr621065459+FARS2chr65771524+0.190875320.80912465
ENST00000378610ENST00000324331CDKAL1chr621065459+FARS2chr65771524+0.56369520.4363048

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Fusion Genomic Features for CDKAL1-FARS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDKAL1chr621065459+FARS2chr65771523+9.96E-131
CDKAL1chr621065459+FARS2chr65771523+9.96E-131

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CDKAL1-FARS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:21065459/chr6:5771524)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDKAL1

Q5VV42

.
FUNCTION: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. {ECO:0000250|UniProtKB:Q91WE6}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKAL1chr6:21065459chr6:5771524ENST00000274695+121664_172412580.0DomainMTTase N-terminal
HgeneCDKAL1chr6:21065459chr6:5771524ENST00000378610+101464_172412580.0DomainMTTase N-terminal
HgeneCDKAL1chr6:21065459chr6:5771524ENST00000378624+111464_172342489.0DomainMTTase N-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKAL1chr6:21065459chr6:5771524ENST00000274695+1216200_431412580.0DomainRadical SAM core
HgeneCDKAL1chr6:21065459chr6:5771524ENST00000274695+1216431_493412580.0DomainTRAM
HgeneCDKAL1chr6:21065459chr6:5771524ENST00000378610+1014200_431412580.0DomainRadical SAM core
HgeneCDKAL1chr6:21065459chr6:5771524ENST00000378610+1014431_493412580.0DomainTRAM
HgeneCDKAL1chr6:21065459chr6:5771524ENST00000378624+1114200_431342489.0DomainRadical SAM core
HgeneCDKAL1chr6:21065459chr6:5771524ENST00000378624+1114431_493342489.0DomainTRAM
HgeneCDKAL1chr6:21065459chr6:5771524ENST00000274695+1216556_578412580.0TransmembraneHelical
HgeneCDKAL1chr6:21065459chr6:5771524ENST00000378610+1014556_578412580.0TransmembraneHelical
HgeneCDKAL1chr6:21065459chr6:5771524ENST00000378624+1114556_578342489.0TransmembraneHelical
TgeneFARS2chr6:21065459chr6:5771524ENST0000027468057358_450405452.0DomainFDX-ACB
TgeneFARS2chr6:21065459chr6:5771524ENST0000032433157358_450405452.0DomainFDX-ACB
TgeneFARS2chr6:21065459chr6:5771524ENST0000027468057157_160405452.0RegionNote=Substrate binding
TgeneFARS2chr6:21065459chr6:5771524ENST0000027468057186_188405452.0RegionNote=Substrate binding
TgeneFARS2chr6:21065459chr6:5771524ENST0000027468057193_195405452.0RegionNote=Substrate binding
TgeneFARS2chr6:21065459chr6:5771524ENST0000032433157157_160405452.0RegionNote=Substrate binding
TgeneFARS2chr6:21065459chr6:5771524ENST0000032433157186_188405452.0RegionNote=Substrate binding
TgeneFARS2chr6:21065459chr6:5771524ENST0000032433157193_195405452.0RegionNote=Substrate binding


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Fusion Gene Sequence for CDKAL1-FARS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15331_15331_1_CDKAL1-FARS2_CDKAL1_chr6_21065459_ENST00000274695_FARS2_chr6_5771524_ENST00000324331_length(transcript)=1542nt_BP=1403nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGCACTATTCCAGGCATACAGA
AAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCTAGCTGCTTATGGCTATAAAATTA
CAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAA
AAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCA
TTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAGACTGCTGGGTCAGAAAAAGGATA
ATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAATCATTTCCATCAATACCGGGTGTC
TCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGAACTAGTAGATAGAGCCAAACAAT
CTTTTCAAGAGGGTGTTTGTGAGATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATATTGGCACCAATCTCCCCACACTCC
TGTGGAAACTGGTTGAAGTGATTCCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTATATTTTAGAGCATCTGGAGGAAA
TGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGACAGCGTACTCATGGAAATGAAAA
GAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAACTATTGCTACAGATATTATCTGTG
GTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCCAAGCCTGTTTATTAACCAATTTT
ACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCAGCACAAGTGGACGCACAAGACCAGCCACTGCTACCGCATCACGTAC
CGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCCTTGCAGGAGGCTGCAGTCCAGCTGTTGGGTGTGGAG

>15331_15331_1_CDKAL1-FARS2_CDKAL1_chr6_21065459_ENST00000274695_FARS2_chr6_5771524_ENST00000324331_length(amino acids)=458AA_BP=412
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVDAQDQPLLPHHVPPHGTDSVPERGQAHPPGLAGGCSPA

--------------------------------------------------------------
>15331_15331_2_CDKAL1-FARS2_CDKAL1_chr6_21065459_ENST00000378610_FARS2_chr6_5771524_ENST00000324331_length(transcript)=1385nt_BP=1246nt
GGTAGAGAATATGCCTTCTGCATCCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAG
GCATTTTGTAAGAAAGGATGTTGTCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGA
CAGCACTATTCCAGGCATACAGAAAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCT
AGCTGCTTATGGCTATAAAATTACAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGA
CCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGA
CTACCTTAAGGGACTGAGTATCATTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAG
ACTGCTGGGTCAGAAAAAGGATAATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAAT
CATTTCCATCAATACCGGGTGTCTCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGA
ACTAGTAGATAGAGCCAAACAATCTTTTCAAGAGGGTGTTTGTGAGATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATAT
TGGCACCAATCTCCCCACACTCCTGTGGAAACTGGTTGAAGTGATTCCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTA
TATTTTAGAGCATCTGGAGGAAATGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGA
CAGCGTACTCATGGAAATGAAAAGAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAAC
TATTGCTACAGATATTATCTGTGGTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCC
AAGCCTGTTTATTAACCAATTTTACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCAGCACAAGTGGACGCACAAGACCA
GCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCCTTGCAGGAGGCTG

>15331_15331_2_CDKAL1-FARS2_CDKAL1_chr6_21065459_ENST00000378610_FARS2_chr6_5771524_ENST00000324331_length(amino acids)=458AA_BP=412
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVDAQDQPLLPHHVPPHGTDSVPERGQAHPPGLAGGCSPA

--------------------------------------------------------------
>15331_15331_3_CDKAL1-FARS2_CDKAL1_chr6_21065459_ENST00000378624_FARS2_chr6_5771524_ENST00000324331_length(transcript)=1429nt_BP=1290nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGAAAATGCATCCGATGCAGAT
TTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAA
ATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCATTGGGGTTCAGCAGATAGATCGT
GTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAGACTGCTGGGTCAGAAAAAGGATAATGGAAGGCGGCTTGGGGGAGCA
CGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAATCATTTCCATCAATACCGGGTGTCTCAATGCTTGTACCTACTGCAAA
ACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGAACTAGTAGATAGAGCCAAACAATCTTTTCAAGAGGGTGTTTGTGAG
ATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATATTGGCACCAATCTCCCCACACTCCTGTGGAAACTGGTTGAAGTGATT
CCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTATATTTTAGAGCATCTGGAGGAAATGGCAAAAATCCTTAATCACCCC
AGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGACAGCGTACTCATGGAAATGAAAAGAGAATACTGTGTGGCTGACTTC
AAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAACTATTGCTACAGATATTATCTGTGGTTTTCCTGGAGAAACAGATCAG
GATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCCAAGCCTGTTTATTAACCAATTTTACCCAAGACCAGGAACTCCTGCT
GCAAAAATGGAACAAGTTCCAGCACAAGTGGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTC

>15331_15331_3_CDKAL1-FARS2_CDKAL1_chr6_21065459_ENST00000378624_FARS2_chr6_5771524_ENST00000324331_length(amino acids)=388AA_BP=342
MLSRRYEGEIPKNICKRKKTVHQVTENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQI
DRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGV
CEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVA
DFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVDAQDQPLLPHHVPPHGTD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDKAL1-FARS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDKAL1-FARS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDKAL1-FARS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDKAL1C0011860Diabetes Mellitus, Non-Insulin-Dependent3CTD_human
HgeneCDKAL1C0005910Body Weight2CTD_human
HgeneCDKAL1C0005612Birth Weight1CTD_human
HgeneCDKAL1C0263859Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome1CTD_human
TgeneC0023264Leigh Disease7CLINGEN
TgeneC1838951LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY7CLINGEN
TgeneC1850597Leigh Syndrome Due To Mitochondrial Complex II Deficiency7CLINGEN
TgeneC1850598Leigh Syndrome due to Mitochondrial Complex III Deficiency7CLINGEN
TgeneC1850599Leigh Syndrome due to Mitochondrial Complex IV Deficiency7CLINGEN
TgeneC1850600Leigh Syndrome due to Mitochondrial Complex V Deficiency7CLINGEN
TgeneC2931891Necrotizing encephalopathy, infantile subacute, of Leigh7CLINGEN
TgeneC3554168COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 144CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC4310750SPASTIC PARAPLEGIA 77, AUTOSOMAL RECESSIVE3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT