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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDKAL1-ASH1L (FusionGDB2 ID:HG54901TG55870)

Fusion Gene Summary for CDKAL1-ASH1L

check button Fusion gene summary
Fusion gene informationFusion gene name: CDKAL1-ASH1L
Fusion gene ID: hg54901tg55870
HgeneTgene
Gene symbol

CDKAL1

ASH1L

Gene ID

54901

55870

Gene nameCDK5 regulatory subunit associated protein 1 like 1ASH1 like histone lysine methyltransferase
Synonyms-ASH1|ASH1L1|KMT2H|MRD52
Cytomap('CDKAL1')('ASH1L')

6p22.3

1q22

Type of geneprotein-codingprotein-coding
Descriptionthreonylcarbamoyladenosine tRNA methylthiotransferasetRNA-t(6)A37 methylthiotransferasehistone-lysine N-methyltransferase ASH1LASH1-like proteinabsent small and homeotic disks protein 1 homologash1 (absent, small, or homeotic)-likelysine N-methyltransferase 2Hprobable histone-lysine N-methyltransferase ASH1L
Modification date2020032220200313
UniProtAcc

Q5VV42

.
Ensembl transtripts involved in fusion geneENST00000274695, ENST00000378610, 
ENST00000378624, ENST00000476517, 
Fusion gene scores* DoF score37 X 20 X 14=1036017 X 13 X 7=1547
# samples 3918
** MAII scorelog2(39/10360*10)=-4.73140606882431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1547*10)=-3.10340438511936
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDKAL1 [Title/Abstract] AND ASH1L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDKAL1(20846409)-ASH1L(155349907), # samples:4
Anticipated loss of major functional domain due to fusion event.CDKAL1-ASH1L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKAL1-ASH1L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKAL1-ASH1L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKAL1-ASH1L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneASH1L

GO:0097676

histone H3-K36 dimethylation

26002201


check buttonFusion gene breakpoints across CDKAL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ASH1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-33-4587-01ACDKAL1chr6

20846409

-ASH1Lchr1

155349907

-
ChimerDB4LUSCTCGA-33-4587-01ACDKAL1chr6

20846409

+ASH1Lchr1

155349907

-
ChimerDB4LUSCTCGA-33-4587CDKAL1chr6

20846409

+ASH1Lchr1

155349907

-


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Fusion Gene ORF analysis for CDKAL1-ASH1L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000274695ENST00000548830CDKAL1chr6

20846409

+ASH1Lchr1

155349907

-
5CDS-intronENST00000378610ENST00000548830CDKAL1chr6

20846409

+ASH1Lchr1

155349907

-
5CDS-intronENST00000378624ENST00000548830CDKAL1chr6

20846409

+ASH1Lchr1

155349907

-
In-frameENST00000274695ENST00000368346CDKAL1chr6

20846409

+ASH1Lchr1

155349907

-
In-frameENST00000274695ENST00000392403CDKAL1chr6

20846409

+ASH1Lchr1

155349907

-
In-frameENST00000378610ENST00000368346CDKAL1chr6

20846409

+ASH1Lchr1

155349907

-
In-frameENST00000378610ENST00000392403CDKAL1chr6

20846409

+ASH1Lchr1

155349907

-
In-frameENST00000378624ENST00000368346CDKAL1chr6

20846409

+ASH1Lchr1

155349907

-
In-frameENST00000378624ENST00000392403CDKAL1chr6

20846409

+ASH1Lchr1

155349907

-
intron-3CDSENST00000476517ENST00000368346CDKAL1chr6

20846409

+ASH1Lchr1

155349907

-
intron-3CDSENST00000476517ENST00000392403CDKAL1chr6

20846409

+ASH1Lchr1

155349907

-
intron-intronENST00000476517ENST00000548830CDKAL1chr6

20846409

+ASH1Lchr1

155349907

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000274695CDKAL1chr620846409+ENST00000368346ASH1Lchr1155349907-60939091671000277
ENST00000274695CDKAL1chr620846409+ENST00000392403ASH1Lchr1155349907-530690916737001177
ENST00000378624CDKAL1chr620846409+ENST00000368346ASH1Lchr1155349907-5980796264887207
ENST00000378624CDKAL1chr620846409+ENST00000392403ASH1Lchr1155349907-519379626435871107
ENST00000378610CDKAL1chr620846409+ENST00000368346ASH1Lchr1155349907-593675210843277
ENST00000378610CDKAL1chr620846409+ENST00000392403ASH1Lchr1155349907-51497521035431177

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000274695ENST00000368346CDKAL1chr620846409+ASH1Lchr1155349907-0.0006171390.99938285
ENST00000274695ENST00000392403CDKAL1chr620846409+ASH1Lchr1155349907-7.74E-050.99992263
ENST00000378624ENST00000368346CDKAL1chr620846409+ASH1Lchr1155349907-0.0011737280.9988262
ENST00000378624ENST00000392403CDKAL1chr620846409+ASH1Lchr1155349907-8.65E-050.99991345
ENST00000378610ENST00000368346CDKAL1chr620846409+ASH1Lchr1155349907-0.0006287140.99937135
ENST00000378610ENST00000392403CDKAL1chr620846409+ASH1Lchr1155349907-6.81E-050.99993193

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Fusion Genomic Features for CDKAL1-ASH1L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CDKAL1-ASH1L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:20846409/chr1:155349907)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDKAL1

Q5VV42

.
FUNCTION: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. {ECO:0000250|UniProtKB:Q91WE6}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKAL1chr6:20846409chr1:155349907ENST00000274695+91664_172247580.0DomainMTTase N-terminal
HgeneCDKAL1chr6:20846409chr1:155349907ENST00000378610+71464_172247580.0DomainMTTase N-terminal
HgeneCDKAL1chr6:20846409chr1:155349907ENST00000378624+81464_172177489.0DomainMTTase N-terminal
TgeneASH1Lchr6:20846409chr1:155349907ENST000003683460281380_142402970.0Compositional biasNote=Pro-rich
TgeneASH1Lchr6:20846409chr1:155349907ENST000003683460281580_179102970.0Compositional biasNote=Ser-rich
TgeneASH1Lchr6:20846409chr1:155349907ENST000003683460281347_135902970.0DNA bindingNote=A.T hook 2
TgeneASH1Lchr6:20846409chr1:155349907ENST000003683460281847_185902970.0DNA bindingNote=A.T hook 3
TgeneASH1Lchr6:20846409chr1:155349907ENST00000368346028887_89902970.0DNA bindingNote=A.T hook 1
TgeneASH1Lchr6:20846409chr1:155349907ENST000003683460282091_214202970.0DomainAWS
TgeneASH1Lchr6:20846409chr1:155349907ENST000003683460282145_226102970.0DomainSET
TgeneASH1Lchr6:20846409chr1:155349907ENST000003683460282269_228502970.0DomainPost-SET
TgeneASH1Lchr6:20846409chr1:155349907ENST000003683460282463_253302970.0DomainBromo
TgeneASH1Lchr6:20846409chr1:155349907ENST000003683460282661_279802970.0DomainBAH
TgeneASH1Lchr6:20846409chr1:155349907ENST000003924036282091_214220342965.0DomainAWS
TgeneASH1Lchr6:20846409chr1:155349907ENST000003924036282145_226120342965.0DomainSET
TgeneASH1Lchr6:20846409chr1:155349907ENST000003924036282269_228520342965.0DomainPost-SET
TgeneASH1Lchr6:20846409chr1:155349907ENST000003924036282463_253320342965.0DomainBromo
TgeneASH1Lchr6:20846409chr1:155349907ENST000003924036282661_279820342965.0DomainBAH
TgeneASH1Lchr6:20846409chr1:155349907ENST000003683460282069_228802970.0RegionNote=Catalytic domain
TgeneASH1Lchr6:20846409chr1:155349907ENST000003924036282069_228820342965.0RegionNote=Catalytic domain
TgeneASH1Lchr6:20846409chr1:155349907ENST000003683460282585_263102970.0Zinc fingerNote=PHD-type
TgeneASH1Lchr6:20846409chr1:155349907ENST000003924036282585_263120342965.0Zinc fingerNote=PHD-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKAL1chr6:20846409chr1:155349907ENST00000274695+916200_431247580.0DomainRadical SAM core
HgeneCDKAL1chr6:20846409chr1:155349907ENST00000274695+916431_493247580.0DomainTRAM
HgeneCDKAL1chr6:20846409chr1:155349907ENST00000378610+714200_431247580.0DomainRadical SAM core
HgeneCDKAL1chr6:20846409chr1:155349907ENST00000378610+714431_493247580.0DomainTRAM
HgeneCDKAL1chr6:20846409chr1:155349907ENST00000378624+814200_431177489.0DomainRadical SAM core
HgeneCDKAL1chr6:20846409chr1:155349907ENST00000378624+814431_493177489.0DomainTRAM
HgeneCDKAL1chr6:20846409chr1:155349907ENST00000274695+916556_578247580.0TransmembraneHelical
HgeneCDKAL1chr6:20846409chr1:155349907ENST00000378610+714556_578247580.0TransmembraneHelical
HgeneCDKAL1chr6:20846409chr1:155349907ENST00000378624+814556_578177489.0TransmembraneHelical
TgeneASH1Lchr6:20846409chr1:155349907ENST000003924036281380_142420342965.0Compositional biasNote=Pro-rich
TgeneASH1Lchr6:20846409chr1:155349907ENST000003924036281580_179120342965.0Compositional biasNote=Ser-rich
TgeneASH1Lchr6:20846409chr1:155349907ENST000003924036281347_135920342965.0DNA bindingNote=A.T hook 2
TgeneASH1Lchr6:20846409chr1:155349907ENST000003924036281847_185920342965.0DNA bindingNote=A.T hook 3
TgeneASH1Lchr6:20846409chr1:155349907ENST00000392403628887_89920342965.0DNA bindingNote=A.T hook 1


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Fusion Gene Sequence for CDKAL1-ASH1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15322_15322_1_CDKAL1-ASH1L_CDKAL1_chr6_20846409_ENST00000274695_ASH1L_chr1_155349907_ENST00000368346_length(transcript)=6093nt_BP=909nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGCACTATTCCAGGCATACAGA
AAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCTAGCTGCTTATGGCTATAAAATTA
CAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAA
AAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCA
TTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAGACTGCTGGGTCAGAAAAAGGATA
ATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAATCATTTCCATCAATACCGGGTGTC
TCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGAACTAGTAGATAGAGCCAAACAAT
CTTTTCAAGCCATTGATGTGACCTACTTGCTGGAGGAAGGATCAGGCAGGAAACTGCGAAGGCGTACTTTGTTTATCCCAGAAAACAGCT
TTCGAAAGTGACCCTCAAAGAATGAGAACCTCAAGCATCTGGGATCCAGTGGAGCTAATCAGTCCTGCCTCCTGCTCTCTGGGTATAGAC
AGGGGTGGGAAGGGTCCATCTGGGCAAGGGGAATGGGGCCATGTTGTTGACATTAGGTACTTAATAAGCCTTGGAGCTAGTGGAGAGGGA
GAGGAAAGGGTTCTGTCCAAGACAGTTCAGGTTAATTAATTTTCTTCTCCATTGCTTCACCTTAAGGGTTAATAATGTAGAGAGGAGGGA
GGACCACATTGATGACCAGAACCTACTGGTACTTTATAGCATTTGCCCCACCCCACAGCTTAGGTTTTTCTGTCATCCTCAGATCCCACA
GGCATTGCGAAGAAGCTGCTTCCTATACCCAGGTATAACTCAAAATCCAAAGGGATAGGGCCAGGATCCCTATTCCTACCCCATCTATTC
TCTGTTGGCTCCAAGAGCTACCCCAGAGACCTTAAACAGAAACAGTAGCTGAGGCTTCTTCCTAGATACCTGACTAGGGAAGTTTGTCTC
TCCTTTCTTGCCCAACCAGGTCAAAGTAAAATGTGAGTTGACAGCTCAAAGCACTTGTAACTGCTGCCCCCTCCCTACCTCTACTCCCCA
AAATGGAATCATGGGATAGGGAAGGCCCCCATGGGGTCAGAAGGGCACGGTAGTTCTTGCAATTATTTTTGTTTTACCCTTCATAACCTG
TCAAACATATTTTTTTCTAATGAGAAAGCCAGGCCCCCGCCAGCACACATGCTGTTTTTAATGCGCTGTAGTTCTTGTGTGTCTGCTGTG
CTGTGCAAATGGAGATTCAGTTCAAAATAAAATCATTTAAAAACCTACATAAAAAGAACTCTAAACCCACCCCTGCAACAAAAGTCACTA
CATAAACTGTTCAGCAGTATTCACCTATCAGAGTATTTGTTGTGAGTATAGATTATCAATTGAAAACACTACTCTTGTTTTCTTAATTGT
ACAGTTTTCAATGTCCCTTTCTTAAAGAGACAGTATATTTCTCTTCACCCCTAGCCCATCTTCCCTCACCCTCCTGAATGACATCAGGAG
GTATATCCAGGGTGTCTCCTTCCTTCCTACTCTCTTGACCAGAAGTTAACAGACTATACTGTCTCTTTAAAAATAAAATTTAAAAAGCTT
TGTTGTCTTTTCAGACATACATATGCATATATGTTTTAGATGTTCTTATAAGAGAAAAGATGGTTTTTAAATGTGCCAAGTTGTGTGTGT
GTGTGTATATATATGTGTGTATGTGTGTGTATATATATATGTGTGTGTGTATATATATACACACACACACACACACCTGCTGTGTGATTG
GTAAGCAATACAATAGTAAACATGTCCCCATTACTTTTTTCTAATATTGGACCAATGCTGTCCTAATTGTACATTTCCCCTTATGGTGAC
GATGCTCTGACTCGTTTAGGTAGACACATTGACCACCTTCCATTCCATTAAATATTTTTTCCTTTTTCCCCTTTCTGTGTCATTCTTGAG
GAAAAAACAAAAGAGAGAGGGGATGCCAATGATCCCCTTGAGCAGAGAAAAAGCAAAATAAATATTTTATTAAAGAAAAAAGAGAATTAA
GAAAATAGTTTGGAGTATTTTCTTACTGTAGAGAAGCACTGTACATTACTAAGAGACCTGGGTATAAGATACTCACATGTGGAGCTGGAA
AAATCGCATGTCCAAGCCCGTTTGAGTGGTTTCTTTTGTTTTTCATTGCAGGGAGTGGGTGGGAGGGAGGTGGGACTAGGGGCACTTTGG
GGGTCTCCTTTTAGTCAAAAGCGAGAAAATGACAAGAAAGAGATTAAAATTCAATGTTTCCTTTATAGTGTTAAACACTAAAATTTTAAA
AAAGATGAAAAAGAAAAAAAAACTTTGTAAAATGCGAGAACAGAAGCAAAAGACACTACGCTCTGTCATTTTATCTTTCTTTTGTTGAAA
GACTAAAAAAAAACTGAAATGTTTTTTAGACAATCAAATGTTAGGTAAGTGCAAAAACTTGTTTTTTCTTACTGGTGTAGAAATTAATGC
CTTTTTTTATTTTTCAGTTATTTTATAATAACGAAATAAAAAGAACCCCCCAGCTGCCAGGCGGGTTTTGGTGTTTGAAATGCGGGGCAA
AGCACTACATCACTGCAAATAGATACAGAGTTAGTCTGCATGTCTGTAGGCTGTGTGATTGCGGAAAATATAAATGCTGCTAATATATTT
CCTTTTTACAAAAGCATATCTAAATAGATGATTGTTTTGATGTTAATCTTTGTAAATTATGTATTACCAATTTTAACATTGGATGTAATT
GCATACAAAGCTTGCATCTCAATCCTTGAAAGTCTAGTATTAAATGGAAAAAACTTTTCCTAAATCATCCTGGAAGTCTGAGCGCTCAAA
GCCACCCCTAAAAGACTTGGGCCAGGAGGATGATGCTCTACCCTTGATTGAAGAGGTTCTAGCCAGTCAAGAGCAAGCAGCCAATGAGAT
ACCCAGCCTGGAGGAGCCAGAACGGGAAGGGGCCACTGCTAACGTCAGTGAGGGTGAAAAAAAAACAGAGGAAAGTAGTCAAGAACCCCA
GTCAACCTGTACCCCTGAGGAACGACGGCATAACCAACGGGAACGACTCAACCAGATCTTGCTCAATCTCCTTGAAAAAATCCCTGGAAA
AAATGCCTCATTACGTCCCAGACAACTACAAGAGGAATGGAGGACGGGAGACCCAAAGGAGTAAAGGAGCAAGATGTGTACATCTGTGAT
TATCGGCTTGACAAGTCAGCACACCTGTTTTACAAGATCCACCGGAACCGCTATCCTGTCTGCACCAAACCCTATGCTTTTGATCACTTC
CCCAAGAAGCTCACTCCCAAAAAAGATTTCTCGAGAGGAACGGTTTGCCTTTGGTCACCATTATTTCCGTCCCCACGAAACACACCACTC
TCCATCCCGTCGGTTCTATCATAATGAACTATTTCGGGTGCCACTCTATGAGATCATTCCCTTGGAGGCTGTAGTGGGGACCTGCTGTGT
GTTGGACCTTTATACGTATTGTAAAGGTGACTGTGTGTATCTGATGAGGGATAGTCGGCGCACCCCTGATGGCCACCCGGTCCGTCAGTC
CTATCGACTGTTATCTCACATTAACCGAGATAAACTTGACATCTTTCGCATTGAGAAGCTTTGGAAGAATGAAAAGAGGTTCCCATGATC
CCTCGGCCCCACTATGCCCAACCTGGCTGTGTCTACTTCATCTGTTTGCTCCGAGATGACTTGCTGCTTCGTCAGGGTATGGCAGCACTG
TGATTGTATGGGAGTGAACTCAGATGTGGAGCACTACCTTTGTGAGCAGTGTGACCCAAGGCCTGTGGACAGGAAGTACTATGGGCGTAA
ATCCCCAGTTGGGAGAGATGTTTGTCGTCTACGAAAGGCCTATTACAATGCCCGGCATGAGGCATCAGCCCAGATTGATGAGATTGTGGG
AGAGACAGCAAGTGAGGCAGACAGCAGTGAGACCTCAGTCTCTGAAAAGGAGAATGGGCATGAGAAGGACGACGATGTTATTCGCTGTAT
CTGTGGCCTCTACAAGGATGAAGGTCTCATGATCCAGTGTGACAAGTGCATGGAATGCTGATTATTATGAGAAGATCTCTGATCCCCTAG
ATCTTATCACCATAGAGAAGCAGATCCTCACTGGTTACTATAAGACAGTGGAAGCTTTTGATGCTGACATGCTCAAAGTCTTTCGGAATG
CTGAGATTCTTCCCGGCAAGCACTGGCAGCTCCACTTTTGAACCTTCCCCCAAAGAAAAAATGTCTTCATGACCCAGTTCTCTGCCCTGC
AGACAGCTCGATCTGTTCGAACAAGACGGTTGGCAGCTGCAGAGGAAAATATTGAAGTGGCTCGGGCAGCCCGCCTAGCCCAGATCTTCA
AAGAAATTTGTGATGGTATCATCTCTTATAAAGGAACTTTGTGTTAAAGCATCATGTATTCTTGGTCCGAAACTGGGAGAAGATTCGTCA
AAAACAGGAGGAAGTAAAGCACACCAGTGATAATATTCACTCAGCATCATTATATACCCGTTGGAATGGGATCTGCCGAGATGATGGGAA
TATCAAGTCTGAGAGGCCATCTCTCTGAGGAACCCAGTGAAAATATCAACACCCCAACTAGATTGACCCCCCAATTACAGATGAAGCCAA
TGTCCAATCGTGAAAGCAACTTTGTAAGTGTGGCTTTGAGAAATGTCGAGGAATCATCGGAGGCAAGAGTCAGCGTGTGAATGGACTCAC
CAGCAGCAAAAACAGCCAGCCCATGGCCACACACAAAAAATCTGGACGGTCAAAAGAGAAGAGAAAGTCTAAGCACAAGCTGAAGAAAAG
GGTCTGTTAATGGAGTATACCGGATTGGACTCTATGCTCTTAAAGACATGCCAGCTGGGACTGAACTCACTTATGATTATAACTTTCATT
CCTTCAATGTGGAAAAACAGGAACAGGATGATTGAGCAGTATCATAATCACAGTGACCACTACTGCCTGAACCTGGATAGTGGGATGGTG
ATTGACAGTTACCGCATGGGAAATGAGGCCCGATTCATCAACCATAGCTGTGACCCAAATTGTGAAATGCAGAAATGAATGATCTTTGCT
GAGTGTTCCCCCAACACTTGCCCATGTGGCGAGCAATGCTGTAACCAGAGGATACAGAGGCATGAATGGGTGCAATGTCTAGAACGATTT
CGAGCTGAGGAAAAAGGTTGGGGAATCAGAACCAAAGAGCCCCTAAAAGCTGGGCAGTTCATCATTGAATACCTAGGGGAGGTCGTCAGT
GAACAGGAGTTCAGATGTCTACGTTGATGTCAAACCCCTTTCTGGTTACGAAGCTACCACCTGTAACTGTAAGAAGCCAGATGATGACAC
CAGGAAGGGCTGTGTTGATGACTGCCTCAATAGCTATACAAAAAGCCAGATGTCCCACTATATAAGAAAATTCGTTCAAGAAAGTATCTA

>15322_15322_1_CDKAL1-ASH1L_CDKAL1_chr6_20846409_ENST00000274695_ASH1L_chr1_155349907_ENST00000368346_length(amino acids)=277AA_BP=
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQAIDVTYLLEEGSGRKLRRRTLFI

--------------------------------------------------------------
>15322_15322_2_CDKAL1-ASH1L_CDKAL1_chr6_20846409_ENST00000274695_ASH1L_chr1_155349907_ENST00000392403_length(transcript)=5306nt_BP=909nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGCACTATTCCAGGCATACAGA
AAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCTAGCTGCTTATGGCTATAAAATTA
CAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAA
AAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCA
TTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAGACTGCTGGGTCAGAAAAAGGATA
ATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAATCATTTCCATCAATACCGGGTGTC
TCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGAACTAGTAGATAGAGCCAAACAAT
CTTTTCAAGGAAAGTATCTAAGACAAAAGAGAATTGACTTCCAGCTTCCTTATGATATCCTTTGGCAGTGGAAACACAATCAGCTATACA
AAAAGCCAGATGTCCCACTATATAAGAAAATTCGTTCAAATGTCTACGTTGATGTCAAACCCCTTTCTGGTTACGAAGCTACCACCTGTA
ACTGTAAGAAGCCAGATGATGACACCAGGAAGGGCTGTGTTGATGACTGCCTCAATAGAATGATCTTTGCTGAGTGTTCCCCCAACACTT
GCCCATGTGGCGAGCAATGCTGTAACCAGAGGATACAGAGGCATGAATGGGTGCAATGTCTAGAACGATTTCGAGCTGAGGAAAAAGGTT
GGGGAATCAGAACCAAAGAGCCCCTAAAAGCTGGGCAGTTCATCATTGAATACCTAGGGGAGGTCGTCAGTGAACAGGAGTTCAGGAACA
GGATGATTGAGCAGTATCATAATCACAGTGACCACTACTGCCTGAACCTGGATAGTGGGATGGTGATTGACAGTTACCGCATGGGAAATG
AGGCCCGATTCATCAACCATAGCTGTGACCCAAATTGTGAAATGCAGAAATGGTCTGTTAATGGAGTATACCGGATTGGACTCTATGCTC
TTAAAGACATGCCAGCTGGGACTGAACTCACTTATGATTATAACTTTCATTCCTTCAATGTGGAAAAACAGCAACTTTGTAAGTGTGGCT
TTGAGAAATGTCGAGGAATCATCGGAGGCAAGAGTCAGCGTGTGAATGGACTCACCAGCAGCAAAAACAGCCAGCCCATGGCCACACACA
AAAAATCTGGACGGTCAAAAGAGAAGAGAAAGTCTAAGCACAAGCTGAAGAAAAGGAGAGGCCATCTCTCTGAGGAACCCAGTGAAAATA
TCAACACCCCAACTAGATTGACCCCCCAATTACAGATGAAGCCAATGTCCAATCGTGAAAGGAACTTTGTGTTAAAGCATCATGTATTCT
TGGTCCGAAACTGGGAGAAGATTCGTCAAAAACAGGAGGAAGTAAAGCACACCAGTGATAATATTCACTCAGCATCATTATATACCCGTT
GGAATGGGATCTGCCGAGATGATGGGAATATCAAGTCTGATGTCTTCATGACCCAGTTCTCTGCCCTGCAGACAGCTCGATCTGTTCGAA
CAAGACGGTTGGCAGCTGCAGAGGAAAATATTGAAGTGGCTCGGGCAGCCCGCCTAGCCCAGATCTTCAAAGAAATTTGTGATGGTATCA
TCTCTTATAAAGATTCTTCCCGGCAAGCACTGGCAGCTCCACTTTTGAACCTTCCCCCAAAGAAAAAGAATGCTGATTATTATGAGAAGA
TCTCTGATCCCCTAGATCTTATCACCATAGAGAAGCAGATCCTCACTGGTTACTATAAGACAGTGGAAGCTTTTGATGCTGACATGCTCA
AAGTCTTTCGGAATGCTGAGAAGTACTATGGGCGTAAATCCCCAGTTGGGAGAGATGTTTGTCGTCTACGAAAGGCCTATTACAATGCCC
GGCATGAGGCATCAGCCCAGATTGATGAGATTGTGGGAGAGACAGCAAGTGAGGCAGACAGCAGTGAGACCTCAGTCTCTGAAAAGGAGA
ATGGGCATGAGAAGGACGACGATGTTATTCGCTGTATCTGTGGCCTCTACAAGGATGAAGGTCTCATGATCCAGTGTGACAAGTGCATGG
TATGGCAGCACTGTGATTGTATGGGAGTGAACTCAGATGTGGAGCACTACCTTTGTGAGCAGTGTGACCCAAGGCCTGTGGACAGGGAGG
TTCCCATGATCCCTCGGCCCCACTATGCCCAACCTGGCTGTGTCTACTTCATCTGTTTGCTCCGAGATGACTTGCTGCTTCGTCAGGGTG
ACTGTGTGTATCTGATGAGGGATAGTCGGCGCACCCCTGATGGCCACCCGGTCCGTCAGTCCTATCGACTGTTATCTCACATTAACCGAG
ATAAACTTGACATCTTTCGCATTGAGAAGCTTTGGAAGAATGAAAAAGAGGAACGGTTTGCCTTTGGTCACCATTATTTCCGTCCCCACG
AAACACACCACTCTCCATCCCGTCGGTTCTATCATAATGAACTATTTCGGGTGCCACTCTATGAGATCATTCCCTTGGAGGCTGTAGTGG
GGACCTGCTGTGTGTTGGACCTTTATACGTATTGTAAAGGGAGACCCAAAGGAGTAAAGGAGCAAGATGTGTACATCTGTGATTATCGGC
TTGACAAGTCAGCACACCTGTTTTACAAGATCCACCGGAACCGCTATCCTGTCTGCACCAAACCCTATGCTTTTGATCACTTCCCCAAGA
AGCTCACTCCCAAAAAAGATTTCTCGCCTCATTACGTCCCAGACAACTACAAGAGGAATGGAGGACGATCATCCTGGAAGTCTGAGCGCT
CAAAGCCACCCCTAAAAGACTTGGGCCAGGAGGATGATGCTCTACCCTTGATTGAAGAGGTTCTAGCCAGTCAAGAGCAAGCAGCCAATG
AGATACCCAGCCTGGAGGAGCCAGAACGGGAAGGGGCCACTGCTAACGTCAGTGAGGGTGAAAAAAAAACAGAGGAAAGTAGTCAAGAAC
CCCAGTCAACCTGTACCCCTGAGGAACGACGGCATAACCAACGGGAACGACTCAACCAGATCTTGCTCAATCTCCTTGAAAAAATCCCTG
GAAAAAATGCCATTGATGTGACCTACTTGCTGGAGGAAGGATCAGGCAGGAAACTGCGAAGGCGTACTTTGTTTATCCCAGAAAACAGCT
TTCGAAAGTGACCCTCAAAGAATGAGAACCTCAAGCATCTGGGATCCAGTGGAGCTAATCAGTCCTGCCTCCTGCTCTCTGGGTATAGAC
AGGGGTGGGAAGGGTCCATCTGGGCAAGGGGAATGGGGCCATGTTGTTGACATTAGGTACTTAATAAGCCTTGGAGCTAGTGGAGAGGGA
GAGGAAAGGGTTCTGTCCAAGACAGTTCAGGTTAATTAATTTTCTTCTCCATTGCTTCACCTTAAGGGTTAATAATGTAGAGAGGAGGGA
GGACCACATTGATGACCAGAACCTACTGGTACTTTATAGCATTTGCCCCACCCCACAGCTTAGGTTTTTCTGTCATCCTCAGATCCCACA
GGCATTGCGAAGAAGCTGCTTCCTATACCCAGGTATAACTCAAAATCCAAAGGGATAGGGCCAGGATCCCTATTCCTACCCCATCTATTC
TCTGTTGGCTCCAAGAGCTACCCCAGAGACCTTAAACAGAAACAGTAGCTGAGGCTTCTTCCTAGATACCTGACTAGGGAAGTTTGTCTC
TCCTTTCTTGCCCAACCAGGTCAAAGTAAAATGTGAGTTGACAGCTCAAAGCACTTGTAACTGCTGCCCCCTCCCTACCTCTACTCCCCA
AAATGGAATCATGGGATAGGGAAGGCCCCCATGGGGTCAGAAGGGCACGGTAGTTCTTGCAATTATTTTTGTTTTACCCTTCATAACCTG
TCAAACATATTTTTTTCTAATGAGAAAGCCAGGCCCCCGCCAGCACACATGCTGTTTTTAATGCGCTGTAGTTCTTGTGTGTCTGCTGTG
CTGTGCAAATGGAGATTCAGTTCAAAATAAAATCATTTAAAAACCTACATAAAAAGAACTCTAAACCCACCCCTGCAACAAAAGTCACTA
CATAAACTGTTCAGCAGTATTCACCTATCAGAGTATTTGTTGTGAGTATAGATTATCAATTGAAAACACTACTCTTGTTTTCTTAATTGT
ACAGTTTTCAATGTCCCTTTCTTAAAGAGACAGTATATTTCTCTTCACCCCTAGCCCATCTTCCCTCACCCTCCTGAATGACATCAGGAG
GTATATCCAGGGTGTCTCCTTCCTTCCTACTCTCTTGACCAGAAGTTAACAGACTATACTGTCTCTTTAAAAATAAAATTTAAAAAGCTT
TGTTGTCTTTTCAGACATACATATGCATATATGTTTTAGATGTTCTTATAAGAGAAAAGATGGTTTTTAAATGTGCCAAGTTGTGTGTGT
GTGTGTATATATATGTGTGTATGTGTGTGTATATATATATGTGTGTGTGTATATATATACACACACACACACACACCTGCTGTGTGATTG
GTAAGCAATACAATAGTAAACATGTCCCCATTACTTTTTTCTAATATTGGACCAATGCTGTCCTAATTGTACATTTCCCCTTATGGTGAC
GATGCTCTGACTCGTTTAGGTAGACACATTGACCACCTTCCATTCCATTAAATATTTTTTCCTTTTTCCCCTTTCTGTGTCATTCTTGAG

>15322_15322_2_CDKAL1-ASH1L_CDKAL1_chr6_20846409_ENST00000274695_ASH1L_chr1_155349907_ENST00000392403_length(amino acids)=1177AA_BP=247
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQGKYLRQKRIDFQLPYDILWQWKH
NQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRA
EEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRI
GLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSKNSQPMATHKKSGRSKEKRKSKHKLKKRRGHLSEE
PSENINTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKHTSDNIHSASLYTRWNGICRDDGNIKSDVFMTQFSALQTA
RSVRTRRLAAAEENIEVARAARLAQIFKEICDGIISYKDSSRQALAAPLLNLPPKKKNADYYEKISDPLDLITIEKQILTGYYKTVEAFD
ADMLKVFRNAEKYYGRKSPVGRDVCRLRKAYYNARHEASAQIDEIVGETASEADSSETSVSEKENGHEKDDDVIRCICGLYKDEGLMIQC
DKCMVWQHCDCMGVNSDVEHYLCEQCDPRPVDREVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLS
HINRDKLDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGVKEQDVYI
CDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHFPKKLTPKKDFSPHYVPDNYKRNGGRSSWKSERSKPPLKDLGQEDDALPLIEEVLASQE
QAANEIPSLEEPEREGATANVSEGEKKTEESSQEPQSTCTPEERRHNQRERLNQILLNLLEKIPGKNAIDVTYLLEEGSGRKLRRRTLFI

--------------------------------------------------------------
>15322_15322_3_CDKAL1-ASH1L_CDKAL1_chr6_20846409_ENST00000378610_ASH1L_chr1_155349907_ENST00000368346_length(transcript)=5936nt_BP=752nt
GGTAGAGAATATGCCTTCTGCATCCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAG
GCATTTTGTAAGAAAGGATGTTGTCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGA
CAGCACTATTCCAGGCATACAGAAAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCT
AGCTGCTTATGGCTATAAAATTACAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGA
CCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGA
CTACCTTAAGGGACTGAGTATCATTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAG
ACTGCTGGGTCAGAAAAAGGATAATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAAT
CATTTCCATCAATACCGGGTGTCTCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGA
ACTAGTAGATAGAGCCAAACAATCTTTTCAAGCCATTGATGTGACCTACTTGCTGGAGGAAGGATCAGGCAGGAAACTGCGAAGGCGTAC
TTTGTTTATCCCAGAAAACAGCTTTCGAAAGTGACCCTCAAAGAATGAGAACCTCAAGCATCTGGGATCCAGTGGAGCTAATCAGTCCTG
CCTCCTGCTCTCTGGGTATAGACAGGGGTGGGAAGGGTCCATCTGGGCAAGGGGAATGGGGCCATGTTGTTGACATTAGGTACTTAATAA
GCCTTGGAGCTAGTGGAGAGGGAGAGGAAAGGGTTCTGTCCAAGACAGTTCAGGTTAATTAATTTTCTTCTCCATTGCTTCACCTTAAGG
GTTAATAATGTAGAGAGGAGGGAGGACCACATTGATGACCAGAACCTACTGGTACTTTATAGCATTTGCCCCACCCCACAGCTTAGGTTT
TTCTGTCATCCTCAGATCCCACAGGCATTGCGAAGAAGCTGCTTCCTATACCCAGGTATAACTCAAAATCCAAAGGGATAGGGCCAGGAT
CCCTATTCCTACCCCATCTATTCTCTGTTGGCTCCAAGAGCTACCCCAGAGACCTTAAACAGAAACAGTAGCTGAGGCTTCTTCCTAGAT
ACCTGACTAGGGAAGTTTGTCTCTCCTTTCTTGCCCAACCAGGTCAAAGTAAAATGTGAGTTGACAGCTCAAAGCACTTGTAACTGCTGC
CCCCTCCCTACCTCTACTCCCCAAAATGGAATCATGGGATAGGGAAGGCCCCCATGGGGTCAGAAGGGCACGGTAGTTCTTGCAATTATT
TTTGTTTTACCCTTCATAACCTGTCAAACATATTTTTTTCTAATGAGAAAGCCAGGCCCCCGCCAGCACACATGCTGTTTTTAATGCGCT
GTAGTTCTTGTGTGTCTGCTGTGCTGTGCAAATGGAGATTCAGTTCAAAATAAAATCATTTAAAAACCTACATAAAAAGAACTCTAAACC
CACCCCTGCAACAAAAGTCACTACATAAACTGTTCAGCAGTATTCACCTATCAGAGTATTTGTTGTGAGTATAGATTATCAATTGAAAAC
ACTACTCTTGTTTTCTTAATTGTACAGTTTTCAATGTCCCTTTCTTAAAGAGACAGTATATTTCTCTTCACCCCTAGCCCATCTTCCCTC
ACCCTCCTGAATGACATCAGGAGGTATATCCAGGGTGTCTCCTTCCTTCCTACTCTCTTGACCAGAAGTTAACAGACTATACTGTCTCTT
TAAAAATAAAATTTAAAAAGCTTTGTTGTCTTTTCAGACATACATATGCATATATGTTTTAGATGTTCTTATAAGAGAAAAGATGGTTTT
TAAATGTGCCAAGTTGTGTGTGTGTGTGTATATATATGTGTGTATGTGTGTGTATATATATATGTGTGTGTGTATATATATACACACACA
CACACACACCTGCTGTGTGATTGGTAAGCAATACAATAGTAAACATGTCCCCATTACTTTTTTCTAATATTGGACCAATGCTGTCCTAAT
TGTACATTTCCCCTTATGGTGACGATGCTCTGACTCGTTTAGGTAGACACATTGACCACCTTCCATTCCATTAAATATTTTTTCCTTTTT
CCCCTTTCTGTGTCATTCTTGAGGAAAAAACAAAAGAGAGAGGGGATGCCAATGATCCCCTTGAGCAGAGAAAAAGCAAAATAAATATTT
TATTAAAGAAAAAAGAGAATTAAGAAAATAGTTTGGAGTATTTTCTTACTGTAGAGAAGCACTGTACATTACTAAGAGACCTGGGTATAA
GATACTCACATGTGGAGCTGGAAAAATCGCATGTCCAAGCCCGTTTGAGTGGTTTCTTTTGTTTTTCATTGCAGGGAGTGGGTGGGAGGG
AGGTGGGACTAGGGGCACTTTGGGGGTCTCCTTTTAGTCAAAAGCGAGAAAATGACAAGAAAGAGATTAAAATTCAATGTTTCCTTTATA
GTGTTAAACACTAAAATTTTAAAAAAGATGAAAAAGAAAAAAAAACTTTGTAAAATGCGAGAACAGAAGCAAAAGACACTACGCTCTGTC
ATTTTATCTTTCTTTTGTTGAAAGACTAAAAAAAAACTGAAATGTTTTTTAGACAATCAAATGTTAGGTAAGTGCAAAAACTTGTTTTTT
CTTACTGGTGTAGAAATTAATGCCTTTTTTTATTTTTCAGTTATTTTATAATAACGAAATAAAAAGAACCCCCCAGCTGCCAGGCGGGTT
TTGGTGTTTGAAATGCGGGGCAAAGCACTACATCACTGCAAATAGATACAGAGTTAGTCTGCATGTCTGTAGGCTGTGTGATTGCGGAAA
ATATAAATGCTGCTAATATATTTCCTTTTTACAAAAGCATATCTAAATAGATGATTGTTTTGATGTTAATCTTTGTAAATTATGTATTAC
CAATTTTAACATTGGATGTAATTGCATACAAAGCTTGCATCTCAATCCTTGAAAGTCTAGTATTAAATGGAAAAAACTTTTCCTAAATCA
TCCTGGAAGTCTGAGCGCTCAAAGCCACCCCTAAAAGACTTGGGCCAGGAGGATGATGCTCTACCCTTGATTGAAGAGGTTCTAGCCAGT
CAAGAGCAAGCAGCCAATGAGATACCCAGCCTGGAGGAGCCAGAACGGGAAGGGGCCACTGCTAACGTCAGTGAGGGTGAAAAAAAAACA
GAGGAAAGTAGTCAAGAACCCCAGTCAACCTGTACCCCTGAGGAACGACGGCATAACCAACGGGAACGACTCAACCAGATCTTGCTCAAT
CTCCTTGAAAAAATCCCTGGAAAAAATGCCTCATTACGTCCCAGACAACTACAAGAGGAATGGAGGACGGGAGACCCAAAGGAGTAAAGG
AGCAAGATGTGTACATCTGTGATTATCGGCTTGACAAGTCAGCACACCTGTTTTACAAGATCCACCGGAACCGCTATCCTGTCTGCACCA
AACCCTATGCTTTTGATCACTTCCCCAAGAAGCTCACTCCCAAAAAAGATTTCTCGAGAGGAACGGTTTGCCTTTGGTCACCATTATTTC
CGTCCCCACGAAACACACCACTCTCCATCCCGTCGGTTCTATCATAATGAACTATTTCGGGTGCCACTCTATGAGATCATTCCCTTGGAG
GCTGTAGTGGGGACCTGCTGTGTGTTGGACCTTTATACGTATTGTAAAGGTGACTGTGTGTATCTGATGAGGGATAGTCGGCGCACCCCT
GATGGCCACCCGGTCCGTCAGTCCTATCGACTGTTATCTCACATTAACCGAGATAAACTTGACATCTTTCGCATTGAGAAGCTTTGGAAG
AATGAAAAGAGGTTCCCATGATCCCTCGGCCCCACTATGCCCAACCTGGCTGTGTCTACTTCATCTGTTTGCTCCGAGATGACTTGCTGC
TTCGTCAGGGTATGGCAGCACTGTGATTGTATGGGAGTGAACTCAGATGTGGAGCACTACCTTTGTGAGCAGTGTGACCCAAGGCCTGTG
GACAGGAAGTACTATGGGCGTAAATCCCCAGTTGGGAGAGATGTTTGTCGTCTACGAAAGGCCTATTACAATGCCCGGCATGAGGCATCA
GCCCAGATTGATGAGATTGTGGGAGAGACAGCAAGTGAGGCAGACAGCAGTGAGACCTCAGTCTCTGAAAAGGAGAATGGGCATGAGAAG
GACGACGATGTTATTCGCTGTATCTGTGGCCTCTACAAGGATGAAGGTCTCATGATCCAGTGTGACAAGTGCATGGAATGCTGATTATTA
TGAGAAGATCTCTGATCCCCTAGATCTTATCACCATAGAGAAGCAGATCCTCACTGGTTACTATAAGACAGTGGAAGCTTTTGATGCTGA
CATGCTCAAAGTCTTTCGGAATGCTGAGATTCTTCCCGGCAAGCACTGGCAGCTCCACTTTTGAACCTTCCCCCAAAGAAAAAATGTCTT
CATGACCCAGTTCTCTGCCCTGCAGACAGCTCGATCTGTTCGAACAAGACGGTTGGCAGCTGCAGAGGAAAATATTGAAGTGGCTCGGGC
AGCCCGCCTAGCCCAGATCTTCAAAGAAATTTGTGATGGTATCATCTCTTATAAAGGAACTTTGTGTTAAAGCATCATGTATTCTTGGTC
CGAAACTGGGAGAAGATTCGTCAAAAACAGGAGGAAGTAAAGCACACCAGTGATAATATTCACTCAGCATCATTATATACCCGTTGGAAT
GGGATCTGCCGAGATGATGGGAATATCAAGTCTGAGAGGCCATCTCTCTGAGGAACCCAGTGAAAATATCAACACCCCAACTAGATTGAC
CCCCCAATTACAGATGAAGCCAATGTCCAATCGTGAAAGCAACTTTGTAAGTGTGGCTTTGAGAAATGTCGAGGAATCATCGGAGGCAAG
AGTCAGCGTGTGAATGGACTCACCAGCAGCAAAAACAGCCAGCCCATGGCCACACACAAAAAATCTGGACGGTCAAAAGAGAAGAGAAAG
TCTAAGCACAAGCTGAAGAAAAGGGTCTGTTAATGGAGTATACCGGATTGGACTCTATGCTCTTAAAGACATGCCAGCTGGGACTGAACT
CACTTATGATTATAACTTTCATTCCTTCAATGTGGAAAAACAGGAACAGGATGATTGAGCAGTATCATAATCACAGTGACCACTACTGCC
TGAACCTGGATAGTGGGATGGTGATTGACAGTTACCGCATGGGAAATGAGGCCCGATTCATCAACCATAGCTGTGACCCAAATTGTGAAA
TGCAGAAATGAATGATCTTTGCTGAGTGTTCCCCCAACACTTGCCCATGTGGCGAGCAATGCTGTAACCAGAGGATACAGAGGCATGAAT
GGGTGCAATGTCTAGAACGATTTCGAGCTGAGGAAAAAGGTTGGGGAATCAGAACCAAAGAGCCCCTAAAAGCTGGGCAGTTCATCATTG
AATACCTAGGGGAGGTCGTCAGTGAACAGGAGTTCAGATGTCTACGTTGATGTCAAACCCCTTTCTGGTTACGAAGCTACCACCTGTAAC
TGTAAGAAGCCAGATGATGACACCAGGAAGGGCTGTGTTGATGACTGCCTCAATAGCTATACAAAAAGCCAGATGTCCCACTATATAAGA

>15322_15322_3_CDKAL1-ASH1L_CDKAL1_chr6_20846409_ENST00000378610_ASH1L_chr1_155349907_ENST00000368346_length(amino acids)=277AA_BP=
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQAIDVTYLLEEGSGRKLRRRTLFI

--------------------------------------------------------------
>15322_15322_4_CDKAL1-ASH1L_CDKAL1_chr6_20846409_ENST00000378610_ASH1L_chr1_155349907_ENST00000392403_length(transcript)=5149nt_BP=752nt
GGTAGAGAATATGCCTTCTGCATCCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAG
GCATTTTGTAAGAAAGGATGTTGTCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGA
CAGCACTATTCCAGGCATACAGAAAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCT
AGCTGCTTATGGCTATAAAATTACAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGA
CCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGA
CTACCTTAAGGGACTGAGTATCATTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAG
ACTGCTGGGTCAGAAAAAGGATAATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAAT
CATTTCCATCAATACCGGGTGTCTCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGA
ACTAGTAGATAGAGCCAAACAATCTTTTCAAGGAAAGTATCTAAGACAAAAGAGAATTGACTTCCAGCTTCCTTATGATATCCTTTGGCA
GTGGAAACACAATCAGCTATACAAAAAGCCAGATGTCCCACTATATAAGAAAATTCGTTCAAATGTCTACGTTGATGTCAAACCCCTTTC
TGGTTACGAAGCTACCACCTGTAACTGTAAGAAGCCAGATGATGACACCAGGAAGGGCTGTGTTGATGACTGCCTCAATAGAATGATCTT
TGCTGAGTGTTCCCCCAACACTTGCCCATGTGGCGAGCAATGCTGTAACCAGAGGATACAGAGGCATGAATGGGTGCAATGTCTAGAACG
ATTTCGAGCTGAGGAAAAAGGTTGGGGAATCAGAACCAAAGAGCCCCTAAAAGCTGGGCAGTTCATCATTGAATACCTAGGGGAGGTCGT
CAGTGAACAGGAGTTCAGGAACAGGATGATTGAGCAGTATCATAATCACAGTGACCACTACTGCCTGAACCTGGATAGTGGGATGGTGAT
TGACAGTTACCGCATGGGAAATGAGGCCCGATTCATCAACCATAGCTGTGACCCAAATTGTGAAATGCAGAAATGGTCTGTTAATGGAGT
ATACCGGATTGGACTCTATGCTCTTAAAGACATGCCAGCTGGGACTGAACTCACTTATGATTATAACTTTCATTCCTTCAATGTGGAAAA
ACAGCAACTTTGTAAGTGTGGCTTTGAGAAATGTCGAGGAATCATCGGAGGCAAGAGTCAGCGTGTGAATGGACTCACCAGCAGCAAAAA
CAGCCAGCCCATGGCCACACACAAAAAATCTGGACGGTCAAAAGAGAAGAGAAAGTCTAAGCACAAGCTGAAGAAAAGGAGAGGCCATCT
CTCTGAGGAACCCAGTGAAAATATCAACACCCCAACTAGATTGACCCCCCAATTACAGATGAAGCCAATGTCCAATCGTGAAAGGAACTT
TGTGTTAAAGCATCATGTATTCTTGGTCCGAAACTGGGAGAAGATTCGTCAAAAACAGGAGGAAGTAAAGCACACCAGTGATAATATTCA
CTCAGCATCATTATATACCCGTTGGAATGGGATCTGCCGAGATGATGGGAATATCAAGTCTGATGTCTTCATGACCCAGTTCTCTGCCCT
GCAGACAGCTCGATCTGTTCGAACAAGACGGTTGGCAGCTGCAGAGGAAAATATTGAAGTGGCTCGGGCAGCCCGCCTAGCCCAGATCTT
CAAAGAAATTTGTGATGGTATCATCTCTTATAAAGATTCTTCCCGGCAAGCACTGGCAGCTCCACTTTTGAACCTTCCCCCAAAGAAAAA
GAATGCTGATTATTATGAGAAGATCTCTGATCCCCTAGATCTTATCACCATAGAGAAGCAGATCCTCACTGGTTACTATAAGACAGTGGA
AGCTTTTGATGCTGACATGCTCAAAGTCTTTCGGAATGCTGAGAAGTACTATGGGCGTAAATCCCCAGTTGGGAGAGATGTTTGTCGTCT
ACGAAAGGCCTATTACAATGCCCGGCATGAGGCATCAGCCCAGATTGATGAGATTGTGGGAGAGACAGCAAGTGAGGCAGACAGCAGTGA
GACCTCAGTCTCTGAAAAGGAGAATGGGCATGAGAAGGACGACGATGTTATTCGCTGTATCTGTGGCCTCTACAAGGATGAAGGTCTCAT
GATCCAGTGTGACAAGTGCATGGTATGGCAGCACTGTGATTGTATGGGAGTGAACTCAGATGTGGAGCACTACCTTTGTGAGCAGTGTGA
CCCAAGGCCTGTGGACAGGGAGGTTCCCATGATCCCTCGGCCCCACTATGCCCAACCTGGCTGTGTCTACTTCATCTGTTTGCTCCGAGA
TGACTTGCTGCTTCGTCAGGGTGACTGTGTGTATCTGATGAGGGATAGTCGGCGCACCCCTGATGGCCACCCGGTCCGTCAGTCCTATCG
ACTGTTATCTCACATTAACCGAGATAAACTTGACATCTTTCGCATTGAGAAGCTTTGGAAGAATGAAAAAGAGGAACGGTTTGCCTTTGG
TCACCATTATTTCCGTCCCCACGAAACACACCACTCTCCATCCCGTCGGTTCTATCATAATGAACTATTTCGGGTGCCACTCTATGAGAT
CATTCCCTTGGAGGCTGTAGTGGGGACCTGCTGTGTGTTGGACCTTTATACGTATTGTAAAGGGAGACCCAAAGGAGTAAAGGAGCAAGA
TGTGTACATCTGTGATTATCGGCTTGACAAGTCAGCACACCTGTTTTACAAGATCCACCGGAACCGCTATCCTGTCTGCACCAAACCCTA
TGCTTTTGATCACTTCCCCAAGAAGCTCACTCCCAAAAAAGATTTCTCGCCTCATTACGTCCCAGACAACTACAAGAGGAATGGAGGACG
ATCATCCTGGAAGTCTGAGCGCTCAAAGCCACCCCTAAAAGACTTGGGCCAGGAGGATGATGCTCTACCCTTGATTGAAGAGGTTCTAGC
CAGTCAAGAGCAAGCAGCCAATGAGATACCCAGCCTGGAGGAGCCAGAACGGGAAGGGGCCACTGCTAACGTCAGTGAGGGTGAAAAAAA
AACAGAGGAAAGTAGTCAAGAACCCCAGTCAACCTGTACCCCTGAGGAACGACGGCATAACCAACGGGAACGACTCAACCAGATCTTGCT
CAATCTCCTTGAAAAAATCCCTGGAAAAAATGCCATTGATGTGACCTACTTGCTGGAGGAAGGATCAGGCAGGAAACTGCGAAGGCGTAC
TTTGTTTATCCCAGAAAACAGCTTTCGAAAGTGACCCTCAAAGAATGAGAACCTCAAGCATCTGGGATCCAGTGGAGCTAATCAGTCCTG
CCTCCTGCTCTCTGGGTATAGACAGGGGTGGGAAGGGTCCATCTGGGCAAGGGGAATGGGGCCATGTTGTTGACATTAGGTACTTAATAA
GCCTTGGAGCTAGTGGAGAGGGAGAGGAAAGGGTTCTGTCCAAGACAGTTCAGGTTAATTAATTTTCTTCTCCATTGCTTCACCTTAAGG
GTTAATAATGTAGAGAGGAGGGAGGACCACATTGATGACCAGAACCTACTGGTACTTTATAGCATTTGCCCCACCCCACAGCTTAGGTTT
TTCTGTCATCCTCAGATCCCACAGGCATTGCGAAGAAGCTGCTTCCTATACCCAGGTATAACTCAAAATCCAAAGGGATAGGGCCAGGAT
CCCTATTCCTACCCCATCTATTCTCTGTTGGCTCCAAGAGCTACCCCAGAGACCTTAAACAGAAACAGTAGCTGAGGCTTCTTCCTAGAT
ACCTGACTAGGGAAGTTTGTCTCTCCTTTCTTGCCCAACCAGGTCAAAGTAAAATGTGAGTTGACAGCTCAAAGCACTTGTAACTGCTGC
CCCCTCCCTACCTCTACTCCCCAAAATGGAATCATGGGATAGGGAAGGCCCCCATGGGGTCAGAAGGGCACGGTAGTTCTTGCAATTATT
TTTGTTTTACCCTTCATAACCTGTCAAACATATTTTTTTCTAATGAGAAAGCCAGGCCCCCGCCAGCACACATGCTGTTTTTAATGCGCT
GTAGTTCTTGTGTGTCTGCTGTGCTGTGCAAATGGAGATTCAGTTCAAAATAAAATCATTTAAAAACCTACATAAAAAGAACTCTAAACC
CACCCCTGCAACAAAAGTCACTACATAAACTGTTCAGCAGTATTCACCTATCAGAGTATTTGTTGTGAGTATAGATTATCAATTGAAAAC
ACTACTCTTGTTTTCTTAATTGTACAGTTTTCAATGTCCCTTTCTTAAAGAGACAGTATATTTCTCTTCACCCCTAGCCCATCTTCCCTC
ACCCTCCTGAATGACATCAGGAGGTATATCCAGGGTGTCTCCTTCCTTCCTACTCTCTTGACCAGAAGTTAACAGACTATACTGTCTCTT
TAAAAATAAAATTTAAAAAGCTTTGTTGTCTTTTCAGACATACATATGCATATATGTTTTAGATGTTCTTATAAGAGAAAAGATGGTTTT
TAAATGTGCCAAGTTGTGTGTGTGTGTGTATATATATGTGTGTATGTGTGTGTATATATATATGTGTGTGTGTATATATATACACACACA
CACACACACCTGCTGTGTGATTGGTAAGCAATACAATAGTAAACATGTCCCCATTACTTTTTTCTAATATTGGACCAATGCTGTCCTAAT
TGTACATTTCCCCTTATGGTGACGATGCTCTGACTCGTTTAGGTAGACACATTGACCACCTTCCATTCCATTAAATATTTTTTCCTTTTT
CCCCTTTCTGTGTCATTCTTGAGGAAAAAACAAAAGAGAGAGGGGATGCCAATGATCCCCTTGAGCAGAGAAAAAGCAAAATAAATATTT

>15322_15322_4_CDKAL1-ASH1L_CDKAL1_chr6_20846409_ENST00000378610_ASH1L_chr1_155349907_ENST00000392403_length(amino acids)=1177AA_BP=247
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQGKYLRQKRIDFQLPYDILWQWKH
NQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRA
EEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRI
GLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSKNSQPMATHKKSGRSKEKRKSKHKLKKRRGHLSEE
PSENINTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKHTSDNIHSASLYTRWNGICRDDGNIKSDVFMTQFSALQTA
RSVRTRRLAAAEENIEVARAARLAQIFKEICDGIISYKDSSRQALAAPLLNLPPKKKNADYYEKISDPLDLITIEKQILTGYYKTVEAFD
ADMLKVFRNAEKYYGRKSPVGRDVCRLRKAYYNARHEASAQIDEIVGETASEADSSETSVSEKENGHEKDDDVIRCICGLYKDEGLMIQC
DKCMVWQHCDCMGVNSDVEHYLCEQCDPRPVDREVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLS
HINRDKLDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGVKEQDVYI
CDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHFPKKLTPKKDFSPHYVPDNYKRNGGRSSWKSERSKPPLKDLGQEDDALPLIEEVLASQE
QAANEIPSLEEPEREGATANVSEGEKKTEESSQEPQSTCTPEERRHNQRERLNQILLNLLEKIPGKNAIDVTYLLEEGSGRKLRRRTLFI

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>15322_15322_5_CDKAL1-ASH1L_CDKAL1_chr6_20846409_ENST00000378624_ASH1L_chr1_155349907_ENST00000368346_length(transcript)=5980nt_BP=796nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGAAAATGCATCCGATGCAGAT
TTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAA
ATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCATTGGGGTTCAGCAGATAGATCGT
GTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAGACTGCTGGGTCAGAAAAAGGATAATGGAAGGCGGCTTGGGGGAGCA
CGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAATCATTTCCATCAATACCGGGTGTCTCAATGCTTGTACCTACTGCAAA
ACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGAACTAGTAGATAGAGCCAAACAATCTTTTCAAGCCATTGATGTGACC
TACTTGCTGGAGGAAGGATCAGGCAGGAAACTGCGAAGGCGTACTTTGTTTATCCCAGAAAACAGCTTTCGAAAGTGACCCTCAAAGAAT
GAGAACCTCAAGCATCTGGGATCCAGTGGAGCTAATCAGTCCTGCCTCCTGCTCTCTGGGTATAGACAGGGGTGGGAAGGGTCCATCTGG
GCAAGGGGAATGGGGCCATGTTGTTGACATTAGGTACTTAATAAGCCTTGGAGCTAGTGGAGAGGGAGAGGAAAGGGTTCTGTCCAAGAC
AGTTCAGGTTAATTAATTTTCTTCTCCATTGCTTCACCTTAAGGGTTAATAATGTAGAGAGGAGGGAGGACCACATTGATGACCAGAACC
TACTGGTACTTTATAGCATTTGCCCCACCCCACAGCTTAGGTTTTTCTGTCATCCTCAGATCCCACAGGCATTGCGAAGAAGCTGCTTCC
TATACCCAGGTATAACTCAAAATCCAAAGGGATAGGGCCAGGATCCCTATTCCTACCCCATCTATTCTCTGTTGGCTCCAAGAGCTACCC
CAGAGACCTTAAACAGAAACAGTAGCTGAGGCTTCTTCCTAGATACCTGACTAGGGAAGTTTGTCTCTCCTTTCTTGCCCAACCAGGTCA
AAGTAAAATGTGAGTTGACAGCTCAAAGCACTTGTAACTGCTGCCCCCTCCCTACCTCTACTCCCCAAAATGGAATCATGGGATAGGGAA
GGCCCCCATGGGGTCAGAAGGGCACGGTAGTTCTTGCAATTATTTTTGTTTTACCCTTCATAACCTGTCAAACATATTTTTTTCTAATGA
GAAAGCCAGGCCCCCGCCAGCACACATGCTGTTTTTAATGCGCTGTAGTTCTTGTGTGTCTGCTGTGCTGTGCAAATGGAGATTCAGTTC
AAAATAAAATCATTTAAAAACCTACATAAAAAGAACTCTAAACCCACCCCTGCAACAAAAGTCACTACATAAACTGTTCAGCAGTATTCA
CCTATCAGAGTATTTGTTGTGAGTATAGATTATCAATTGAAAACACTACTCTTGTTTTCTTAATTGTACAGTTTTCAATGTCCCTTTCTT
AAAGAGACAGTATATTTCTCTTCACCCCTAGCCCATCTTCCCTCACCCTCCTGAATGACATCAGGAGGTATATCCAGGGTGTCTCCTTCC
TTCCTACTCTCTTGACCAGAAGTTAACAGACTATACTGTCTCTTTAAAAATAAAATTTAAAAAGCTTTGTTGTCTTTTCAGACATACATA
TGCATATATGTTTTAGATGTTCTTATAAGAGAAAAGATGGTTTTTAAATGTGCCAAGTTGTGTGTGTGTGTGTATATATATGTGTGTATG
TGTGTGTATATATATATGTGTGTGTGTATATATATACACACACACACACACACCTGCTGTGTGATTGGTAAGCAATACAATAGTAAACAT
GTCCCCATTACTTTTTTCTAATATTGGACCAATGCTGTCCTAATTGTACATTTCCCCTTATGGTGACGATGCTCTGACTCGTTTAGGTAG
ACACATTGACCACCTTCCATTCCATTAAATATTTTTTCCTTTTTCCCCTTTCTGTGTCATTCTTGAGGAAAAAACAAAAGAGAGAGGGGA
TGCCAATGATCCCCTTGAGCAGAGAAAAAGCAAAATAAATATTTTATTAAAGAAAAAAGAGAATTAAGAAAATAGTTTGGAGTATTTTCT
TACTGTAGAGAAGCACTGTACATTACTAAGAGACCTGGGTATAAGATACTCACATGTGGAGCTGGAAAAATCGCATGTCCAAGCCCGTTT
GAGTGGTTTCTTTTGTTTTTCATTGCAGGGAGTGGGTGGGAGGGAGGTGGGACTAGGGGCACTTTGGGGGTCTCCTTTTAGTCAAAAGCG
AGAAAATGACAAGAAAGAGATTAAAATTCAATGTTTCCTTTATAGTGTTAAACACTAAAATTTTAAAAAAGATGAAAAAGAAAAAAAAAC
TTTGTAAAATGCGAGAACAGAAGCAAAAGACACTACGCTCTGTCATTTTATCTTTCTTTTGTTGAAAGACTAAAAAAAAACTGAAATGTT
TTTTAGACAATCAAATGTTAGGTAAGTGCAAAAACTTGTTTTTTCTTACTGGTGTAGAAATTAATGCCTTTTTTTATTTTTCAGTTATTT
TATAATAACGAAATAAAAAGAACCCCCCAGCTGCCAGGCGGGTTTTGGTGTTTGAAATGCGGGGCAAAGCACTACATCACTGCAAATAGA
TACAGAGTTAGTCTGCATGTCTGTAGGCTGTGTGATTGCGGAAAATATAAATGCTGCTAATATATTTCCTTTTTACAAAAGCATATCTAA
ATAGATGATTGTTTTGATGTTAATCTTTGTAAATTATGTATTACCAATTTTAACATTGGATGTAATTGCATACAAAGCTTGCATCTCAAT
CCTTGAAAGTCTAGTATTAAATGGAAAAAACTTTTCCTAAATCATCCTGGAAGTCTGAGCGCTCAAAGCCACCCCTAAAAGACTTGGGCC
AGGAGGATGATGCTCTACCCTTGATTGAAGAGGTTCTAGCCAGTCAAGAGCAAGCAGCCAATGAGATACCCAGCCTGGAGGAGCCAGAAC
GGGAAGGGGCCACTGCTAACGTCAGTGAGGGTGAAAAAAAAACAGAGGAAAGTAGTCAAGAACCCCAGTCAACCTGTACCCCTGAGGAAC
GACGGCATAACCAACGGGAACGACTCAACCAGATCTTGCTCAATCTCCTTGAAAAAATCCCTGGAAAAAATGCCTCATTACGTCCCAGAC
AACTACAAGAGGAATGGAGGACGGGAGACCCAAAGGAGTAAAGGAGCAAGATGTGTACATCTGTGATTATCGGCTTGACAAGTCAGCACA
CCTGTTTTACAAGATCCACCGGAACCGCTATCCTGTCTGCACCAAACCCTATGCTTTTGATCACTTCCCCAAGAAGCTCACTCCCAAAAA
AGATTTCTCGAGAGGAACGGTTTGCCTTTGGTCACCATTATTTCCGTCCCCACGAAACACACCACTCTCCATCCCGTCGGTTCTATCATA
ATGAACTATTTCGGGTGCCACTCTATGAGATCATTCCCTTGGAGGCTGTAGTGGGGACCTGCTGTGTGTTGGACCTTTATACGTATTGTA
AAGGTGACTGTGTGTATCTGATGAGGGATAGTCGGCGCACCCCTGATGGCCACCCGGTCCGTCAGTCCTATCGACTGTTATCTCACATTA
ACCGAGATAAACTTGACATCTTTCGCATTGAGAAGCTTTGGAAGAATGAAAAGAGGTTCCCATGATCCCTCGGCCCCACTATGCCCAACC
TGGCTGTGTCTACTTCATCTGTTTGCTCCGAGATGACTTGCTGCTTCGTCAGGGTATGGCAGCACTGTGATTGTATGGGAGTGAACTCAG
ATGTGGAGCACTACCTTTGTGAGCAGTGTGACCCAAGGCCTGTGGACAGGAAGTACTATGGGCGTAAATCCCCAGTTGGGAGAGATGTTT
GTCGTCTACGAAAGGCCTATTACAATGCCCGGCATGAGGCATCAGCCCAGATTGATGAGATTGTGGGAGAGACAGCAAGTGAGGCAGACA
GCAGTGAGACCTCAGTCTCTGAAAAGGAGAATGGGCATGAGAAGGACGACGATGTTATTCGCTGTATCTGTGGCCTCTACAAGGATGAAG
GTCTCATGATCCAGTGTGACAAGTGCATGGAATGCTGATTATTATGAGAAGATCTCTGATCCCCTAGATCTTATCACCATAGAGAAGCAG
ATCCTCACTGGTTACTATAAGACAGTGGAAGCTTTTGATGCTGACATGCTCAAAGTCTTTCGGAATGCTGAGATTCTTCCCGGCAAGCAC
TGGCAGCTCCACTTTTGAACCTTCCCCCAAAGAAAAAATGTCTTCATGACCCAGTTCTCTGCCCTGCAGACAGCTCGATCTGTTCGAACA
AGACGGTTGGCAGCTGCAGAGGAAAATATTGAAGTGGCTCGGGCAGCCCGCCTAGCCCAGATCTTCAAAGAAATTTGTGATGGTATCATC
TCTTATAAAGGAACTTTGTGTTAAAGCATCATGTATTCTTGGTCCGAAACTGGGAGAAGATTCGTCAAAAACAGGAGGAAGTAAAGCACA
CCAGTGATAATATTCACTCAGCATCATTATATACCCGTTGGAATGGGATCTGCCGAGATGATGGGAATATCAAGTCTGAGAGGCCATCTC
TCTGAGGAACCCAGTGAAAATATCAACACCCCAACTAGATTGACCCCCCAATTACAGATGAAGCCAATGTCCAATCGTGAAAGCAACTTT
GTAAGTGTGGCTTTGAGAAATGTCGAGGAATCATCGGAGGCAAGAGTCAGCGTGTGAATGGACTCACCAGCAGCAAAAACAGCCAGCCCA
TGGCCACACACAAAAAATCTGGACGGTCAAAAGAGAAGAGAAAGTCTAAGCACAAGCTGAAGAAAAGGGTCTGTTAATGGAGTATACCGG
ATTGGACTCTATGCTCTTAAAGACATGCCAGCTGGGACTGAACTCACTTATGATTATAACTTTCATTCCTTCAATGTGGAAAAACAGGAA
CAGGATGATTGAGCAGTATCATAATCACAGTGACCACTACTGCCTGAACCTGGATAGTGGGATGGTGATTGACAGTTACCGCATGGGAAA
TGAGGCCCGATTCATCAACCATAGCTGTGACCCAAATTGTGAAATGCAGAAATGAATGATCTTTGCTGAGTGTTCCCCCAACACTTGCCC
ATGTGGCGAGCAATGCTGTAACCAGAGGATACAGAGGCATGAATGGGTGCAATGTCTAGAACGATTTCGAGCTGAGGAAAAAGGTTGGGG
AATCAGAACCAAAGAGCCCCTAAAAGCTGGGCAGTTCATCATTGAATACCTAGGGGAGGTCGTCAGTGAACAGGAGTTCAGATGTCTACG
TTGATGTCAAACCCCTTTCTGGTTACGAAGCTACCACCTGTAACTGTAAGAAGCCAGATGATGACACCAGGAAGGGCTGTGTTGATGACT
GCCTCAATAGCTATACAAAAAGCCAGATGTCCCACTATATAAGAAAATTCGTTCAAGAAAGTATCTAAGACAAAAGAGAATTGACTTCCA

>15322_15322_5_CDKAL1-ASH1L_CDKAL1_chr6_20846409_ENST00000378624_ASH1L_chr1_155349907_ENST00000368346_length(amino acids)=207AA_BP=
MLSRRYEGEIPKNICKRKKTVHQVTENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQI
DRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQAID

--------------------------------------------------------------
>15322_15322_6_CDKAL1-ASH1L_CDKAL1_chr6_20846409_ENST00000378624_ASH1L_chr1_155349907_ENST00000392403_length(transcript)=5193nt_BP=796nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGAAAATGCATCCGATGCAGAT
TTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAA
ATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCATTGGGGTTCAGCAGATAGATCGT
GTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAGACTGCTGGGTCAGAAAAAGGATAATGGAAGGCGGCTTGGGGGAGCA
CGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAATCATTTCCATCAATACCGGGTGTCTCAATGCTTGTACCTACTGCAAA
ACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGAACTAGTAGATAGAGCCAAACAATCTTTTCAAGGAAAGTATCTAAGA
CAAAAGAGAATTGACTTCCAGCTTCCTTATGATATCCTTTGGCAGTGGAAACACAATCAGCTATACAAAAAGCCAGATGTCCCACTATAT
AAGAAAATTCGTTCAAATGTCTACGTTGATGTCAAACCCCTTTCTGGTTACGAAGCTACCACCTGTAACTGTAAGAAGCCAGATGATGAC
ACCAGGAAGGGCTGTGTTGATGACTGCCTCAATAGAATGATCTTTGCTGAGTGTTCCCCCAACACTTGCCCATGTGGCGAGCAATGCTGT
AACCAGAGGATACAGAGGCATGAATGGGTGCAATGTCTAGAACGATTTCGAGCTGAGGAAAAAGGTTGGGGAATCAGAACCAAAGAGCCC
CTAAAAGCTGGGCAGTTCATCATTGAATACCTAGGGGAGGTCGTCAGTGAACAGGAGTTCAGGAACAGGATGATTGAGCAGTATCATAAT
CACAGTGACCACTACTGCCTGAACCTGGATAGTGGGATGGTGATTGACAGTTACCGCATGGGAAATGAGGCCCGATTCATCAACCATAGC
TGTGACCCAAATTGTGAAATGCAGAAATGGTCTGTTAATGGAGTATACCGGATTGGACTCTATGCTCTTAAAGACATGCCAGCTGGGACT
GAACTCACTTATGATTATAACTTTCATTCCTTCAATGTGGAAAAACAGCAACTTTGTAAGTGTGGCTTTGAGAAATGTCGAGGAATCATC
GGAGGCAAGAGTCAGCGTGTGAATGGACTCACCAGCAGCAAAAACAGCCAGCCCATGGCCACACACAAAAAATCTGGACGGTCAAAAGAG
AAGAGAAAGTCTAAGCACAAGCTGAAGAAAAGGAGAGGCCATCTCTCTGAGGAACCCAGTGAAAATATCAACACCCCAACTAGATTGACC
CCCCAATTACAGATGAAGCCAATGTCCAATCGTGAAAGGAACTTTGTGTTAAAGCATCATGTATTCTTGGTCCGAAACTGGGAGAAGATT
CGTCAAAAACAGGAGGAAGTAAAGCACACCAGTGATAATATTCACTCAGCATCATTATATACCCGTTGGAATGGGATCTGCCGAGATGAT
GGGAATATCAAGTCTGATGTCTTCATGACCCAGTTCTCTGCCCTGCAGACAGCTCGATCTGTTCGAACAAGACGGTTGGCAGCTGCAGAG
GAAAATATTGAAGTGGCTCGGGCAGCCCGCCTAGCCCAGATCTTCAAAGAAATTTGTGATGGTATCATCTCTTATAAAGATTCTTCCCGG
CAAGCACTGGCAGCTCCACTTTTGAACCTTCCCCCAAAGAAAAAGAATGCTGATTATTATGAGAAGATCTCTGATCCCCTAGATCTTATC
ACCATAGAGAAGCAGATCCTCACTGGTTACTATAAGACAGTGGAAGCTTTTGATGCTGACATGCTCAAAGTCTTTCGGAATGCTGAGAAG
TACTATGGGCGTAAATCCCCAGTTGGGAGAGATGTTTGTCGTCTACGAAAGGCCTATTACAATGCCCGGCATGAGGCATCAGCCCAGATT
GATGAGATTGTGGGAGAGACAGCAAGTGAGGCAGACAGCAGTGAGACCTCAGTCTCTGAAAAGGAGAATGGGCATGAGAAGGACGACGAT
GTTATTCGCTGTATCTGTGGCCTCTACAAGGATGAAGGTCTCATGATCCAGTGTGACAAGTGCATGGTATGGCAGCACTGTGATTGTATG
GGAGTGAACTCAGATGTGGAGCACTACCTTTGTGAGCAGTGTGACCCAAGGCCTGTGGACAGGGAGGTTCCCATGATCCCTCGGCCCCAC
TATGCCCAACCTGGCTGTGTCTACTTCATCTGTTTGCTCCGAGATGACTTGCTGCTTCGTCAGGGTGACTGTGTGTATCTGATGAGGGAT
AGTCGGCGCACCCCTGATGGCCACCCGGTCCGTCAGTCCTATCGACTGTTATCTCACATTAACCGAGATAAACTTGACATCTTTCGCATT
GAGAAGCTTTGGAAGAATGAAAAAGAGGAACGGTTTGCCTTTGGTCACCATTATTTCCGTCCCCACGAAACACACCACTCTCCATCCCGT
CGGTTCTATCATAATGAACTATTTCGGGTGCCACTCTATGAGATCATTCCCTTGGAGGCTGTAGTGGGGACCTGCTGTGTGTTGGACCTT
TATACGTATTGTAAAGGGAGACCCAAAGGAGTAAAGGAGCAAGATGTGTACATCTGTGATTATCGGCTTGACAAGTCAGCACACCTGTTT
TACAAGATCCACCGGAACCGCTATCCTGTCTGCACCAAACCCTATGCTTTTGATCACTTCCCCAAGAAGCTCACTCCCAAAAAAGATTTC
TCGCCTCATTACGTCCCAGACAACTACAAGAGGAATGGAGGACGATCATCCTGGAAGTCTGAGCGCTCAAAGCCACCCCTAAAAGACTTG
GGCCAGGAGGATGATGCTCTACCCTTGATTGAAGAGGTTCTAGCCAGTCAAGAGCAAGCAGCCAATGAGATACCCAGCCTGGAGGAGCCA
GAACGGGAAGGGGCCACTGCTAACGTCAGTGAGGGTGAAAAAAAAACAGAGGAAAGTAGTCAAGAACCCCAGTCAACCTGTACCCCTGAG
GAACGACGGCATAACCAACGGGAACGACTCAACCAGATCTTGCTCAATCTCCTTGAAAAAATCCCTGGAAAAAATGCCATTGATGTGACC
TACTTGCTGGAGGAAGGATCAGGCAGGAAACTGCGAAGGCGTACTTTGTTTATCCCAGAAAACAGCTTTCGAAAGTGACCCTCAAAGAAT
GAGAACCTCAAGCATCTGGGATCCAGTGGAGCTAATCAGTCCTGCCTCCTGCTCTCTGGGTATAGACAGGGGTGGGAAGGGTCCATCTGG
GCAAGGGGAATGGGGCCATGTTGTTGACATTAGGTACTTAATAAGCCTTGGAGCTAGTGGAGAGGGAGAGGAAAGGGTTCTGTCCAAGAC
AGTTCAGGTTAATTAATTTTCTTCTCCATTGCTTCACCTTAAGGGTTAATAATGTAGAGAGGAGGGAGGACCACATTGATGACCAGAACC
TACTGGTACTTTATAGCATTTGCCCCACCCCACAGCTTAGGTTTTTCTGTCATCCTCAGATCCCACAGGCATTGCGAAGAAGCTGCTTCC
TATACCCAGGTATAACTCAAAATCCAAAGGGATAGGGCCAGGATCCCTATTCCTACCCCATCTATTCTCTGTTGGCTCCAAGAGCTACCC
CAGAGACCTTAAACAGAAACAGTAGCTGAGGCTTCTTCCTAGATACCTGACTAGGGAAGTTTGTCTCTCCTTTCTTGCCCAACCAGGTCA
AAGTAAAATGTGAGTTGACAGCTCAAAGCACTTGTAACTGCTGCCCCCTCCCTACCTCTACTCCCCAAAATGGAATCATGGGATAGGGAA
GGCCCCCATGGGGTCAGAAGGGCACGGTAGTTCTTGCAATTATTTTTGTTTTACCCTTCATAACCTGTCAAACATATTTTTTTCTAATGA
GAAAGCCAGGCCCCCGCCAGCACACATGCTGTTTTTAATGCGCTGTAGTTCTTGTGTGTCTGCTGTGCTGTGCAAATGGAGATTCAGTTC
AAAATAAAATCATTTAAAAACCTACATAAAAAGAACTCTAAACCCACCCCTGCAACAAAAGTCACTACATAAACTGTTCAGCAGTATTCA
CCTATCAGAGTATTTGTTGTGAGTATAGATTATCAATTGAAAACACTACTCTTGTTTTCTTAATTGTACAGTTTTCAATGTCCCTTTCTT
AAAGAGACAGTATATTTCTCTTCACCCCTAGCCCATCTTCCCTCACCCTCCTGAATGACATCAGGAGGTATATCCAGGGTGTCTCCTTCC
TTCCTACTCTCTTGACCAGAAGTTAACAGACTATACTGTCTCTTTAAAAATAAAATTTAAAAAGCTTTGTTGTCTTTTCAGACATACATA
TGCATATATGTTTTAGATGTTCTTATAAGAGAAAAGATGGTTTTTAAATGTGCCAAGTTGTGTGTGTGTGTGTATATATATGTGTGTATG
TGTGTGTATATATATATGTGTGTGTGTATATATATACACACACACACACACACCTGCTGTGTGATTGGTAAGCAATACAATAGTAAACAT
GTCCCCATTACTTTTTTCTAATATTGGACCAATGCTGTCCTAATTGTACATTTCCCCTTATGGTGACGATGCTCTGACTCGTTTAGGTAG
ACACATTGACCACCTTCCATTCCATTAAATATTTTTTCCTTTTTCCCCTTTCTGTGTCATTCTTGAGGAAAAAACAAAAGAGAGAGGGGA

>15322_15322_6_CDKAL1-ASH1L_CDKAL1_chr6_20846409_ENST00000378624_ASH1L_chr1_155349907_ENST00000392403_length(amino acids)=1107AA_BP=177
MLSRRYEGEIPKNICKRKKTVHQVTENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQI
DRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQGKY
LRQKRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQ
CCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFIN
HSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSKNSQPMATHKKSGRS
KEKRKSKHKLKKRRGHLSEEPSENINTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKHTSDNIHSASLYTRWNGICR
DDGNIKSDVFMTQFSALQTARSVRTRRLAAAEENIEVARAARLAQIFKEICDGIISYKDSSRQALAAPLLNLPPKKKNADYYEKISDPLD
LITIEKQILTGYYKTVEAFDADMLKVFRNAEKYYGRKSPVGRDVCRLRKAYYNARHEASAQIDEIVGETASEADSSETSVSEKENGHEKD
DDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNSDVEHYLCEQCDPRPVDREVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLM
RDSRRTPDGHPVRQSYRLLSHINRDKLDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVL
DLYTYCKGRPKGVKEQDVYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHFPKKLTPKKDFSPHYVPDNYKRNGGRSSWKSERSKPPLK
DLGQEDDALPLIEEVLASQEQAANEIPSLEEPEREGATANVSEGEKKTEESSQEPQSTCTPEERRHNQRERLNQILLNLLEKIPGKNAID

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Fusion Gene PPI Analysis for CDKAL1-ASH1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDKAL1-ASH1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDKAL1-ASH1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDKAL1C0011860Diabetes Mellitus, Non-Insulin-Dependent3CTD_human
HgeneCDKAL1C0005910Body Weight2CTD_human
HgeneCDKAL1C0005612Birth Weight1CTD_human
HgeneCDKAL1C0263859Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome1CTD_human
TgeneC4540478MENTAL RETARDATION, AUTOSOMAL DOMINANT 524GENOMICS_ENGLAND;UNIPROT
TgeneC3714756Intellectual Disability2GENOMICS_ENGLAND
TgeneC0023903Liver neoplasms1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0345904Malignant neoplasm of liver1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC1535926Neurodevelopmental Disorders1CTD_human