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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DUS2-UNC5C (FusionGDB2 ID:HG54920TG8633)

Fusion Gene Summary for DUS2-UNC5C

check button Fusion gene summary
Fusion gene informationFusion gene name: DUS2-UNC5C
Fusion gene ID: hg54920tg8633
HgeneTgene
Gene symbol

DUS2

UNC5C

Gene ID

54920

8633

Gene namedihydrouridine synthase 2unc-5 netrin receptor C
SynonymsDUS2L|SMM1|URLC8UNC5H3
Cytomap('DUS2L','DUS2')('UNC5C','UNC5C')

16q22.1

4q22.3

Type of geneprotein-codingprotein-coding
DescriptiontRNA-dihydrouridine(20) synthase [NAD(P)+]-likeSMM1 homologdihydrouridine synthase 2-like, SMM1 homologtRNA-dihydrouridine(20) synthase (NAD(P)(+))up-regulated in lung cancer protein 8netrin receptor UNC5Cprotein unc-5 homolog 3protein unc-5 homolog Cunc-5 homolog 3unc-5 homolog Cunc5 (C.elegans homolog) c
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000358896, ENST00000432752, 
ENST00000565263, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 3=48
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DUS2 [Title/Abstract] AND UNC5C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDUS2(68072052)-UNC5C(96171818), # samples:1
DUS2L(68072052)-UNC5C(96171818), # samples:2
Anticipated loss of major functional domain due to fusion event.DUS2-UNC5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DUS2-UNC5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DUS2-UNC5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DUS2-UNC5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDUS2

GO:0002943

tRNA dihydrouridine synthesis

26429968

HgeneDUS2

GO:0060548

negative regulation of cell death

18096616

TgeneUNC5C

GO:1990791

dorsal root ganglion development

28483977


check buttonFusion gene breakpoints across DUS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across UNC5C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A15T-01ADUS2chr16

68072052

+UNC5Cchr4

96171818

-
ChimerDB4BRCATCGA-E2-A15T-01ADUS2Lchr16

68072052

-UNC5Cchr4

96171818

-
ChimerDB4BRCATCGA-E2-A15T-01ADUS2Lchr16

68072052

+UNC5Cchr4

96171818

-


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Fusion Gene ORF analysis for DUS2-UNC5C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000358896ENST00000453304DUS2chr16

68072052

+UNC5Cchr4

96171818

-
In-frameENST00000358896ENST00000504962DUS2chr16

68072052

+UNC5Cchr4

96171818

-
In-frameENST00000358896ENST00000506749DUS2chr16

68072052

+UNC5Cchr4

96171818

-
In-frameENST00000432752ENST00000453304DUS2chr16

68072052

+UNC5Cchr4

96171818

-
In-frameENST00000432752ENST00000504962DUS2chr16

68072052

+UNC5Cchr4

96171818

-
In-frameENST00000432752ENST00000506749DUS2chr16

68072052

+UNC5Cchr4

96171818

-
In-frameENST00000565263ENST00000453304DUS2chr16

68072052

+UNC5Cchr4

96171818

-
In-frameENST00000565263ENST00000504962DUS2chr16

68072052

+UNC5Cchr4

96171818

-
In-frameENST00000565263ENST00000506749DUS2chr16

68072052

+UNC5Cchr4

96171818

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000565263DUS2chr1668072052+ENST00000453304UNC5Cchr496171818-95526204942821775
ENST00000565263DUS2chr1668072052+ENST00000506749UNC5Cchr496171818-18976204941819441
ENST00000565263DUS2chr1668072052+ENST00000504962UNC5Cchr496171818-147262092448118
ENST00000358896DUS2chr1668072052+ENST00000453304UNC5Cchr496171818-91752431172444775
ENST00000358896DUS2chr1668072052+ENST00000506749UNC5Cchr496171818-15202431171442441
ENST00000358896DUS2chr1668072052+ENST00000504962UNC5Cchr496171818-1095243117431104
ENST00000432752DUS2chr1668072052+ENST00000453304UNC5Cchr496171818-92162841582485775
ENST00000432752DUS2chr1668072052+ENST00000506749UNC5Cchr496171818-15612841581483441
ENST00000432752DUS2chr1668072052+ENST00000504962UNC5Cchr496171818-1136284158472104

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000565263ENST00000453304DUS2chr1668072052+UNC5Cchr496171818-0.0004304080.9995696
ENST00000565263ENST00000506749DUS2chr1668072052+UNC5Cchr496171818-0.001820840.9981792
ENST00000565263ENST00000504962DUS2chr1668072052+UNC5Cchr496171818-0.52972090.4702791
ENST00000358896ENST00000453304DUS2chr1668072052+UNC5Cchr496171818-0.0003780830.99962187
ENST00000358896ENST00000506749DUS2chr1668072052+UNC5Cchr496171818-0.0010674350.99893254
ENST00000358896ENST00000504962DUS2chr1668072052+UNC5Cchr496171818-0.0489088260.9510912
ENST00000432752ENST00000453304DUS2chr1668072052+UNC5Cchr496171818-0.0003902620.99960977
ENST00000432752ENST00000506749DUS2chr1668072052+UNC5Cchr496171818-0.0009219240.99907804
ENST00000432752ENST00000504962DUS2chr1668072052+UNC5Cchr496171818-0.0299570520.9700429

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Fusion Genomic Features for DUS2-UNC5C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DUS2-UNC5C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:68072052/chr4:96171818)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDUS2chr16:68072052chr4:96171818ENST00000358896+21618_2042494.0Nucleotide bindingFMN
HgeneDUS2chr16:68072052chr4:96171818ENST00000565263+31718_2042494.0Nucleotide bindingFMN
TgeneUNC5Cchr16:68072052chr4:96171818ENST00000453304316260_314198932.0DomainTSP type-1 1
TgeneUNC5Cchr16:68072052chr4:96171818ENST00000453304316316_368198932.0DomainTSP type-1 2
TgeneUNC5Cchr16:68072052chr4:96171818ENST00000453304316530_673198932.0DomainZU5
TgeneUNC5Cchr16:68072052chr4:96171818ENST00000453304316850_929198932.0DomainNote=Death
TgeneUNC5Cchr16:68072052chr4:96171818ENST00000506749311260_314198598.0DomainTSP type-1 1
TgeneUNC5Cchr16:68072052chr4:96171818ENST00000506749311316_368198598.0DomainTSP type-1 2
TgeneUNC5Cchr16:68072052chr4:96171818ENST00000506749311530_673198598.0DomainZU5
TgeneUNC5Cchr16:68072052chr4:96171818ENST00000506749311850_929198598.0DomainNote=Death
TgeneUNC5Cchr16:68072052chr4:96171818ENST00000453304316402_931198932.0RegionRequired for netrin-mediated axon repulsion of neuronal growth cones
TgeneUNC5Cchr16:68072052chr4:96171818ENST00000506749311402_931198598.0RegionRequired for netrin-mediated axon repulsion of neuronal growth cones
TgeneUNC5Cchr16:68072052chr4:96171818ENST00000453304316381_401198932.0TransmembraneHelical
TgeneUNC5Cchr16:68072052chr4:96171818ENST00000506749311381_401198598.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDUS2chr16:68072052chr4:96171818ENST00000358896+216369_43642494.0DomainDRBM
HgeneDUS2chr16:68072052chr4:96171818ENST00000565263+317369_43642494.0DomainDRBM
HgeneDUS2chr16:68072052chr4:96171818ENST00000358896+216214_21642494.0Nucleotide bindingFMN
HgeneDUS2chr16:68072052chr4:96171818ENST00000358896+216242_24342494.0Nucleotide bindingFMN
HgeneDUS2chr16:68072052chr4:96171818ENST00000565263+317214_21642494.0Nucleotide bindingFMN
HgeneDUS2chr16:68072052chr4:96171818ENST00000565263+317242_24342494.0Nucleotide bindingFMN
HgeneDUS2chr16:68072052chr4:96171818ENST00000358896+2161_33342494.0RegionCatalytic domain
HgeneDUS2chr16:68072052chr4:96171818ENST00000565263+3171_33342494.0RegionCatalytic domain
TgeneUNC5Cchr16:68072052chr4:96171818ENST00000453304316161_256198932.0DomainNote=Ig-like C2-type
TgeneUNC5Cchr16:68072052chr4:96171818ENST0000045330431662_159198932.0DomainNote=Ig-like
TgeneUNC5Cchr16:68072052chr4:96171818ENST00000506749311161_256198598.0DomainNote=Ig-like C2-type
TgeneUNC5Cchr16:68072052chr4:96171818ENST0000050674931162_159198598.0DomainNote=Ig-like
TgeneUNC5Cchr16:68072052chr4:96171818ENST0000045330431641_380198932.0Topological domainExtracellular
TgeneUNC5Cchr16:68072052chr4:96171818ENST0000050674931141_380198598.0Topological domainExtracellular


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Fusion Gene Sequence for DUS2-UNC5C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24448_24448_1_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000358896_UNC5C_chr4_96171818_ENST00000453304_length(transcript)=9175nt_BP=243nt
GCGACCTCGCGTACGGTGGCTGGCGAGGCTCAGTACGGTGTGTGGAGCTGGAGCACCGTGAGGAAGAAGCGAGGTTCTTTTTAAGAGTTC
AGCTGCGAGGCTGTAACAGAGGAGGAAATGATTTTGAATAGCCTCTCTCTGTGTTACCATAATAAGCTAATCCTGGCCCCAATGGTTCGG
GTAGGGACTCTTCCAATGAGGCTGCTGGCCCTGGATTATGGAGCGGACATTGTTTACTGTGAGGTGGAATGGTTGAAAAATGAAGACATA
ATTGATCCCGTTGAAGATCGGAATTTTTATATTACTATTGATCACAACCTCATCATAAAGCAGGCCCGACTCTCTGATACTGCAAATTAC
ACCTGTGTTGCCAAAAACATTGTTGCCAAGAGGAAAAGTACAACTGCCACTGTCATAGTCTATGTCAACGGTGGCTGGTCCACCTGGACG
GAGTGGTCTGTGTGTAACAGCCGCTGTGGACGAGGGTATCAGAAACGTACAAGGACTTGTACCAACCCGGCACCACTCAATGGGGGTGCC
TTCTGTGAAGGGCAGAGTGTGCAGAAAATAGCCTGTACTACGTTATGCCCAGTGGATGGCAGGTGGACGCCATGGAGCAAGTGGTCTACT
TGTGGAACTGAGTGCACCCACTGGCGCAGGAGGGAGTGCACGGCGCCAGCCCCCAAGAATGGAGGCAAGGACTGCGACGGCCTCGTCTTG
CAATCCAAGAACTGCACTGATGGGCTTTGCATGCAGACTGCTCCTGATTCAGATGATGTTGCTCTCTATGTTGGGATTGTGATAGCAGTG
ATCGTTTGCCTGGCGATCTCTGTAGTTGTGGCCTTGTTTGTGTATCGGAAGAATCATCGTGACTTTGAGTCAGATATTATTGACTCTTCG
GCACTCAATGGGGGCTTTCAGCCTGTGAACATCAAGGCAGCAAGACAAGATCTGCTGGCTGTACCCCCAGACCTCACGTCAGCTGCAGCC
ATGTACAGAGGACCTGTCTATGCCCTGCATGACGTCTCAGACAAAATCCCAATGACCAACTCTCCAATTCTGGATCCACTGCCCAACCTG
AAAATCAAAGTGTACAACACCTCAGGTGCTGTCACCCCCCAAGATGACCTCTCTGAGTTTACGTCCAAGCTGTCCCCTCAGATGACCCAG
TCGTTGTTGGAGAATGAAGCCCTCAGCCTGAAGAACCAGAGTCTAGCAAGGCAGACTGATCCATCCTGTACCGCATTTGGCAGCTTCAAC
TCGCTGGGAGGTCACCTTATTGTTCCCAATTCAGGAGTCAGCTTGCTGATTCCCGCTGGGGCCATTCCCCAAGGGAGAGTCTACGAAATG
TATGTGACTGTACACAGGAAAGAAACTATGAGGCCACCCATGGATGACTCTCAGACACTTTTGACCCCTGTGGTGAGCTGTGGGCCCCCA
GGAGCTCTGCTCACCCGCCCAGTCGTCCTCACTATGCATCACTGCGCAGACCCCAATACCGAGGACTGGAAAATACTGCTCAAGAACCAG
GCAGCACAGGGACAGTGGGAGGATGTGGTGGTGGTCGGGGAGGAAAACTTCACCACCCCCTGCTACATTCAGCTGGATGCAGAGGCCTGC
CACATCCTCACAGAGAACCTCAGCACCTACGCCCTGGTAGGACATTCCACCACCAAAGCGGCTGCGAAGCGCCTCAAGCTGGCCATCTTT
GGGCCCCTGTGCTGCTCCTCGCTGGAGTACAGCATCCGAGTCTACTGTCTGGATGACACCCAGGATGCCCTGAAGGAAATTTTACATCTT
GAGAGACAGATGGGAGGACAGCTCCTAGAAGAACCTAAGGCTCTTCATTTTAAAGGCAGCACCCACAACCTGCGCCTGTCAATTCACGAT
ATCGCCCATTCCCTCTGGAAGAGCAAATTGCTGGCTAAATATCAGGAAATTCCATTTTACCATGTTTGGAGTGGATCTCAAAGAAACCTG
CACTGCACCTTCACTCTGGAAAGATTTAGCCTGAACACAGTGGAGCTGGTTTGCAAACTCTGTGTGCGGCAGGTGGAAGGAGAAGGGCAG
ATCTTCCAGCTCAACTGCACCGTGTCAGAGGAACCTACTGGCATCGATTTGCCGCTGCTGGATCCTGCGAACACCATCACCACGGTCACG
GGGCCCAGTGCTTTCAGCATCCCTCTCCCTATCCGGCAGAAGCTCTGTAGCAGCCTGGATGCCCCCCAGACGAGAGGCCATGACTGGAGG
ATGCTGGCCCATAAGCTGAACCTGGACAGGTACTTGAATTACTTTGCCACCAAATCCAGCCCAACTGGCGTAATCCTGGATCTTTGGGAA
GCACAGAACTTCCCAGATGGAAACCTGAGCATGCTGGCAGCTGTCTTGGAAGAAATGGGAAGACATGAAACGGTGGTGTCCTTAGCAGCA
GAAGGGCAGTATTAACCACCATGCTGGAAGGGGAAATGAAGGACAAAAATGCACAGGGAGTCTGTGGCCGTCCAGGTGAATCACAGCTGA
GGAGGAAATCCAGATGAGACCAATGCACTTCACAGGCAAGACTGCAGCAGGAGCCAGAAGGAAAACAGATACAACTGCCCATGTACATGC
CCACTTTACTCGGACATCATCACGGGAGTTAAGAAAAATTGTGTAAATTTGTACCTTGAATTTAGCTATCAACCTAATTTTCCTCTTAGT
TGGGCTGTATGCTGTGTGGTACAGGATCTTACAGTTTCCTAGGAAACGCTTTTTATTGCTATCCAGATATATGGATAAACTTTCTTAACA
AACCCAATTTCTACAAATGTTGTTTACATCAAATTGGACAGGGATGCAGACACTGTCCATGGCTCGTTCTATTTTTGTTCAAATCATTTG
AAGTTGAAGCTGTGGACGGTTTGTTGTGTCTATTTCAGATTAGTAATTTACAGAGAAATCACAGACTTTTGCTACAAATCGTGTGCATCA
AGTGTCTCAGATAATCCTCCCATCAGTGTTCTGTTTCTAGAACTTGTAGAACCAGTGTTACTGTTTGTATCAGGGAAGTGGAGAATCTAA
GTGTAAAAAAGAAATAACTAAGACTCCTATTCCTTGGAGGGACCCTTCTGGTGCCCTTTGGGAATAAAGCTGTAGCACTGCAGGGAAGAC
AGTGATTCATGTTCAACCCCACAAACAAGCATTTTTTTCACAACATGTGTGTTTGTTTGTAATATGCAATATGAAGTGTTTTTTTTTAAA
GGTATTATTATTATTTACAGGTATTCTGGTAAAATGATTTTTTTAAATTTCTATTTTTGTTAGCAGTGCTGTTTGTTAGTATTTGGTTAT
TGACTAGACCTGTCCCACCTTTTCACCTATCAAGGTGGGTGTGGTCATCAGTTTAATTCAACATGCATCACTTCCTTGACCTTTTACCTT
TCCCTTATTCCACCCCAGAAAGGTGATTGATAAATGCTGAATGGCTTTGTCAGTCTGTTCCTTCAGCTTGCTCAGGCAGGGTCTTTCTTT
CTCCTCTGAGGAGTCTTAAGGAGACGTGTTCTCTATTAAGTTCACTTAATATTGCCGTTGTGTGGCCCCACGTCGACTCCCTATGGTGCT
CTACTCTAGAGGCAGTGTGGTTGGAGGAATGGACTCTAAACTGGAGATCAAGAAACCAGTTCTCATTGTGGGTCTGTCACTGTCTTGTTG
CGCCACCTTGAGAAAGTCATTTAACCACACGACCTCAGTGTCCTCACTAGAAAGTGAAAGGGTGGGATTAGATCATCTCCAAGTTCTGAA
ATGCTCAACTTCCACCGTGATGCCTCCAGTCTCATTCATCAGTCTGAAGACCACAATGGACTCTGACCTGGATCATCATTTAAAAATCAT
CAGCTGGTCTTTTGCCCAGGCTATGTTACGCCTTTCAAGTAGTTCTGACAAGGAAGATGATTATTCTAACCAGCATTATGATGTTGTTTG
TTTGGCCTGAGTCGCTCTGCATCATTGCATTATGCTGTTCACTGAGAGATGACATCCCTTTATTATCATTTTCTTAGCCTCTCTTGGGAT
GCCCCTGCCCCCAGCCTTCCTGACTGGTTGCAAATTCTGTTTTTTATTATTGTCTTGGCATCTTGATATCTAGACCACTCCTACAAGTTT
ATCTGGCAGTAGGAACTTGGTGCATTTTTTTCTACGCTACACCCCCCCACCCTTAATCTTTCTTTGCTGTCATAATATTCAGTAGCATTT
ATAAAAGCTGTCTAGTTAGCTCTTTAAAAACTTTTGTCCTGCAAAATGTTTGTTAGTCAACACACTACTTTGTGTAAACAACTATTATGT
TTCCTTGGGACCATCACAAGCTCTTTAACAAACACAAGGACTCAATTCATTCAGCAGGTGGGGATTAAAGAATCAAAGCCCAGTAGCAAA
ACCAAAACTGAAGAACAAGCAGACATGTGTATGAATCGGAACCTTTAGAACATGACTGTGGTTTACTTTTAGGCTGGAGGCACACAAGTT
GCTGAACAGACTTGAATTATACATGTGCTTCCATCTTTCCATGTTTCCGCTCCTATTTTGGTAGCATCTTGAGATTCCTTGATGCCTCCG
CCATCCTCATCCCTGAGGAACTGCTGATACCTTGCTATGGAACCTCTTCTTTCTTTCATGCTTTTTATTCCGTATCTTCTGTTTTGGACA
TACATACATATATTCTATAAAATCTCTCTCAGCCCACCCCCTGCATTAGGATTTCCATATTTAAAATATTTGTACACTGACTGGGGAAGG
GAGAGATTGCACTATAAACAAGTTCAGTGGATGTTTGTAGCAATGAGTAAAACTGTATTCTAAATTAAAAATCAAATATATATACACGCA
GTTATACACACACATTTTTTAAAAGGAGGAGGAGGAAAGAGAGCTATTGTCCATTCCTACATTTTGAAATAAACTTGTCAAGATTACGCA
TCAGTACCAGGGTTGTGGAATCATCTATGGAAATCAAGAACTAGAATCTGAACTGAATGGTCAAAGAAACTTCTATGCCTAGTGAAAACT
AGAGGGGAGCAACTATGTAGCTATGAACATGAATCAATTCCATAACTGTTACTAAAAACTTATTTTGACTAAAAAGTCACCAACACAGAA
CTATTGAACACAAACAGGAATTGTTTGTCTTACTGAAGTCACTGAGAACCCTTGGGGTTCACTTCAGATGCTTTTTTGGTTCAACTTCCC
ACCACCAGAAAAGGGAAAAGTGATTGATTTCGTGTGTGAGGTACTCATCTGTCAGAACCCTTAATGTTTCCTATTAAGTGAATGACAACT
TCCATACATACACTATTTATACCAAATAATTTTCACTACAAATTCTGATTTCCTTCTCCTTTGGAGTAAAGTAATAGCTGTTAGATTGCT
TTCAAACTTAGAAGGTCCAGATATAACAGTTCATTTCATAGGAAGCCACTTCATCAACCATTCTATGTGATACATCCTGCTTCTTTCTAC
ACCGCTGGAGAGGCAGTTTGGCTGGTTTCATTTGGATAGAAAAAACTATCATTTGTGCATGCTGCCATCTAGTGGTGTACAACACAATCT
AACCTGAGTTTAATATTCACTAGAATGTGTTTGACGAAGGGAATGAAAACCTGTAGAGTTCAAGGACCTTTATGACAAACAGATGTAGGG
AAATTTTCACTTCAAATTTATAATTTTCTTATTCTCACTTTTTTTTCATTTGCATCACTCATCTCAATATTAGGTCACTGTGAGCCCAGT
ACATCAACTCATTCATACACAACATATCTTCAGTTGCTTCTTGTAACAGAACTATGTAAAATCTATATAAAACAGTCTTTGAAGAGTTGT
CATTTTTAACACTTATGGTTTTCATTGGGGTTTGTATACTTTAAATCTCCTTTTAGTTCCTTAATATTTATCTTTGGAAATGTAAGAAGT
ATCTGCTTAGAAAGAAATAAGTCTTATATATGCGAATGGAATACTATGTCTAGGGAAGAGAAAATTGGGGTTGTTAATCAAAGGGAAGAA
AGCAGCTTCTTTTCTGCTGAATTTGGGAATCCAAAGGCAGAGGTTTCATCCTGTTTTTATTTTCTTCTTATCACACTCTTTCAAGTTTCC
TTAATGTATCTGGAAGGAATAGAAGTTGGATTCAGAATTGATAACTGGCATGGTGATGACAAACCTGTGTAACACCAAGGTTCTCACAGC
TAACAGCTGTTTCACAAACGGCATCTTCCAAATGAACAGTCACCTCTGCTATGCAGAAAACCCCCATCCTGCTGTGAGCAAGTTAGGCTC
TTCAAGAACTGGACAACTTTTGGGTGAGGTGTTCAATATCAAACTGCATAATCATTAGCCATTTTCATATATACTATTTTATAGATTTAA
GTCTCTCAACTATCAAAAAGTAGAGCGATTTTCAGGAGAAAAAAGTCGTGGGGACTGAGTTCAGGACACCCTGAAACTATGCGACCAGTA
ATTTTTTTAAGGTATTTTTTCCTACAAGTAAGGTATCTGAAAAGTCAACGTTTTGAGGGTGGAATCAAGACTTTTCACTTCTCCTGGCAA
AGAGCAACAAGGCTCTTGTCTCGTGTCCTTCTGTGTGTCTCTGTCAGGATCACAGCAGCTGTGCTCTTGGTCTGCTTACTCCTCTGTAAT
CCACGTATGCAGAAGGGAGTTAATAAGGTGATCACCATCTCCCCAGAATTCAAAGGTCTTTGCCTCTATAAGGTCTGCCCCTATGGGGCC
AGGAAAATATAAACCTATATAAGGACTTGCAAGAGAGCATAAAGAAGGTAGAAAAGGTTTACTTGTTGGGTTTTCAAGCCTTCAAGTTGA
ATGAGTCTTAGCTTTTGCTGGGCAGTTGTTCTGGACAAGTCATCAGTTTCATGTGGAGAACTCAGTGTAAGCCCAAGGCTAATGAATGAG
AGGGGTCCCATGGAAACACAGCTGAAATGAAATGGGACTTTATCCATCTTCTTTGAGAATGGAAGAGCTTTTGTGAAGCAGTACATCATT
GCTCAAGATAATGGTTGATAAGCATTAGATTTTATAGATCTAATAAGGAAAATATTTTATTATCTCAAGTTAACAAAACATTTTTTTACC
TCTCGAGTGCCTCATAGGACCAACTATTACTCTTTGGCTTTTATTTTTCTTTTTGTATTATTTTTATATATTCTTTAACCTTGCTGAGCT
AGTATTGACTGAAATCTTTAGAACTTTGCCTCTGGGCAATGAAGTAATGTTTCTCTACCCTAAGATATCTATTTGTATAATCTCTGGCTG
TAATGATCACTTTGGAAGATTTCCTTTGCATCTCTAATTATTTCTTTTTAATGGAATAAGGCATAAGGGGGAATAAATATATTGTAACCA
ATGTTATGTAAACCCATATCCATACAGGCCAGGAAAGCCAAATGAAGTCATTTCCAGAATTCTAGTGTGAAAAACCTATTTTTGAAAAGT
GGGGAGATGGCTTTGTGTAGAACTGGGTGGGTTTTCTCTGCAGACTAAGTCTAGCCATGAGCTTCCAGATCCTTTAGTTTTATCAGCCTT
GTGCTTACCCCATTTTCATAAATGCTACTTTAACAGCCAGTCTTCATAAGTCATGGTTCCTAGGTTTTCCTGTCACCTCATTGTATTCAT
CTGTGGTAGGATATTAACGGGCTCATTCAACCAAATGTAATGTGTGCCTCAGACCTATTTAGCATGGTTGGGGGGCATCAGCAGGACAAA
CCAACAGGTACTCCGCAAGTGTACTGGCACAGCAAGCCCACCAATTATTAGCAGCTCTTCATCAGCCTGCTGTCTACTCAGACGCTTGCC
TACTGAAGGGACCTGTCCAGAGATCTTCTGGAATCCCAGGTTGGGAATCTCTGCAGAATGTCGTGACAGTTGTGGCCCAACTAGCTTCTG
AGTAGAAACAAGGAAGCTACCCTGAGATATAGTCAGCTGCCCACCTGCCATAGTATTTGCTACTGAATGCCAGCCTTTTAACATACCATT
TCAGATTTGTCCTTCAACAAAAATATAAATTGCAAGTCATACCATTTAAGGGTCTTTTACAAATATGTCTAAATTGTGTGTCATTTTTAA
GTTCCAAAGGTCTACTGGACTAAGTACTATCAGACCAGCTGTAGAACCTGATGGCGCTGATCCGGGGTGGAATAACCCTCAGTACTGGTG
TGTAGAAGATGAATTGTAGGCAGGTTTTGCTGATCAGCAGCCTAAGGATTGATGGGCTCTCTTTTGGCCTCTGATCCTGAGCACTATGGA
GGCAGCATCAGAGAATGGGGACCTGAGCTACATAGGTTCTCAATGTTAAAACAACTCTGTTCGGAGTGACATATAAGAGCAAGAAATCTA
CAGCTGGTGTAAAATACCTTTGCCTTTTCTATCCCGAAAGTAACAAATGGCATCTGTACATGTAGGGGTAAAAACTCAGATGTCTACTCC
TCCAGGCCATGGACAAGAAAAAGTACAGCAGTCAGAACAGTGGAACAAGTGATTTGCATTCTCTTCTTCACGCTTTCCTAGATCTGCCAT
TGGTAGCGCAGCCCTCGCCCTCCAGACATAATGCATCGAGCCCAGTTGCAGGGAACATCACTGTGTGTGTGTGATGTCATGGTGTTATAT
GTGTTGAGTTTAATGTTGAGCTGAAGCAAGTTGGTGACCTTCCTCTTTGCTCTTTGTAAAGAAGACACCAATGTTTGTCAGAGAAAAATC
CCCAGCAGTCGTGTTGAAGAGGCAGTGTCATCCACCTACTGTCCCCTTTGGAACAGTTCAACTGCAGAAAGGTCGGATTGAGGTTTTGTG
CTTTGTCGTTTTTCTTTTTTAAACAAAACATGACAACCTTGGCTTTTCCGATATGGAACACTTTTGTTGTTGTGGAGTTCCCTCTTGCTG
TATCTTCTATGCAATTCCTTTTCTAAAAAAACCCCCCGGCAGAGGCAGAGTGCCCTCCGGATATCTGTCCGGCGCCTTGCTGAGTGGTGG
AGGTGAGGGATACCAGCTCCGGGTGTGCCTCTTTTCTCTCCCTGGCTGCCAATCCTGATTTTCCCTGCAGTCCCCTTGGTTTGTAAATTG

>24448_24448_1_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000358896_UNC5C_chr4_96171818_ENST00000453304_length(amino acids)=775AA_BP=42
MILNSLSLCYHNKLILAPMVRVGTLPMRLLALDYGADIVYCEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVA
KRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWR
RRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPV
NIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALS
LKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVV
LTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLE
YSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERF
SLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLD

--------------------------------------------------------------
>24448_24448_2_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000358896_UNC5C_chr4_96171818_ENST00000504962_length(transcript)=1095nt_BP=243nt
GCGACCTCGCGTACGGTGGCTGGCGAGGCTCAGTACGGTGTGTGGAGCTGGAGCACCGTGAGGAAGAAGCGAGGTTCTTTTTAAGAGTTC
AGCTGCGAGGCTGTAACAGAGGAGGAAATGATTTTGAATAGCCTCTCTCTGTGTTACCATAATAAGCTAATCCTGGCCCCAATGGTTCGG
GTAGGGACTCTTCCAATGAGGCTGCTGGCCCTGGATTATGGAGCGGACATTGTTTACTGTGAGGTGGAATGGTTGAAAAATGAAGACATA
ATTGATCCCGTTGAAGATCGGAATTTTTATATTACTATTGATCACAACCTCATCATAAAGCAGGCCCGACTCTCTGATACTGCAAATTAC
ACCTGTGTTGCCAAAAACATTGTTGCCAAGAGGAAAAGTACAACTGCCACTGTCATAGTCTATGGTCCTTGAGAAACAGCGGGCTCAAGA
TCACTCTGCTAGTCCTGTCTCTTAAAAGCAGGAGAGGAGATTTTCAGCTGAAAGATGGCTTCCCTATACCAGAAGGAAAGTAACATTCTT
ATCCTCAAGGACAGGAAGTTGAGACCACGGGGAAGTTACGATCCAGATAATTCTGTATCGATCTTATTAAAATAACTCTTAATCTTCTTT
TAGCCTTAACACATAATTGACTTTTTCATAACTTGCTACTCTTTGTCCAATTCAATATATAAGCATTCAACTATAACTGCATCTTTGGGT
CTTCATTTTCTTAGGCCATGTAAAAGTTATATTAAGTAAATTTACATGTTTTTCTCCTGTTGATTTGTGTTACACCAATTTAATTCTTAG
GCCCAGCCAAAAAAAAAATCCTAAAAGAGTGGAAGTAAAATATTGCCTACCCCACAGTACCATTCAGATGGATGTGTGTTTATGAGAAGA
GAAACCACTATGCTGTTCCAAAGGATGAATGTAGTGCTGCTTTAAAAATGTCATTTTAATTACAGGAAAAATGGCACAAAAATTTTTTGA
TCCTCTGATTACCCTGAGGTTTAATTTCCTAGTCCAGATAATGGCTGTGTTGAATTGTATGCAATTGCCTTTCTTAAATCACAATAAAAT

>24448_24448_2_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000358896_UNC5C_chr4_96171818_ENST00000504962_length(amino acids)=104AA_BP=42
MILNSLSLCYHNKLILAPMVRVGTLPMRLLALDYGADIVYCEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVA

--------------------------------------------------------------
>24448_24448_3_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000358896_UNC5C_chr4_96171818_ENST00000506749_length(transcript)=1520nt_BP=243nt
GCGACCTCGCGTACGGTGGCTGGCGAGGCTCAGTACGGTGTGTGGAGCTGGAGCACCGTGAGGAAGAAGCGAGGTTCTTTTTAAGAGTTC
AGCTGCGAGGCTGTAACAGAGGAGGAAATGATTTTGAATAGCCTCTCTCTGTGTTACCATAATAAGCTAATCCTGGCCCCAATGGTTCGG
GTAGGGACTCTTCCAATGAGGCTGCTGGCCCTGGATTATGGAGCGGACATTGTTTACTGTGAGGTGGAATGGTTGAAAAATGAAGACATA
ATTGATCCCGTTGAAGATCGGAATTTTTATATTACTATTGATCACAACCTCATCATAAAGCAGGCCCGACTCTCTGATACTGCAAATTAC
ACCTGTGTTGCCAAAAACATTGTTGCCAAGAGGAAAAGTACAACTGCCACTGTCATAGTCTATGTCAACGGTGGCTGGTCCACCTGGACG
GAGTGGTCTGTGTGTAACAGCCGCTGTGGACGAGGGTATCAGAAACGTACAAGGACTTGTACCAACCCGGCACCACTCAATGGGGGTGCC
TTCTGTGAAGGGCAGAGTGTGCAGAAAATAGCCTGTACTACGTTATGCCCAGTGGATGGCAGGTGGACGCCATGGAGCAAGTGGTCTACT
TGTGGAACTGAGTGCACCCACTGGCGCAGGAGGGAGTGCACGGCGCCAGCCCCCAAGAATGGAGGCAAGGACTGCGACGGCCTCGTCTTG
CAATCCAAGAACTGCACTGATGGGCTTTGCATGCAGAGTTTCATTTATCCCATTTCAACTGAACAGAGAACCCAGAATGAATATGGATTT
TCTTCTGCTCCTGATTCAGATGATGTTGCTCTCTATGTTGGGATTGTGATAGCAGTGATCGTTTGCCTGGCGATCTCTGTAGTTGTGGCC
TTGTTTGTGTATCGGAAGAATCATCGTGACTTTGAGTCAGATATTATTGACTCTTCGGCACTCAATGGGGGCTTTCAGCCTGTGAACATC
AAGGCAGCAAGACAAGATCTGCTGGCTGTACCCCCAGACCTCACGTCAGCTGCAGCCATGTACAGAGGACCTGTCTATGCCCTGCATGAC
GTCTCAGACAAAATCCCAATGACCAACTCTCCAATTCTGGATCCACTGCCCAACCTGAAAATCAAAGTGTACAACACCTCAGGTGCTGTC
ACCCCCCAAGATGACCTCTCTGAGTTTACGTCCAAGCTGTCCCCTCAGATGACCCAGTCGTTGTTGGAGAATGAAGCCCTCAGCCTGAAG
AACCAGAGTCTAGCAAGGCAGACTGATCCATCCTGTACCGCATTTGGCAGCTTCAACTCGCTGGGAGGTCACCTTATTGTTCCCAATTCA
GGAGTCAGCTTGCTGATTCCCGCTGGGGCCATTCCCCAAGGGAGAGTCTACGAAATGTATGTGACTGTACACAGGAAAGAAACTATGAGG

>24448_24448_3_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000358896_UNC5C_chr4_96171818_ENST00000506749_length(amino acids)=441AA_BP=42
MILNSLSLCYHNKLILAPMVRVGTLPMRLLALDYGADIVYCEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVA
KRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWR
RRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQSFIYPISTEQRTQNEYGFSSAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHR
DFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEF

--------------------------------------------------------------
>24448_24448_4_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000432752_UNC5C_chr4_96171818_ENST00000453304_length(transcript)=9216nt_BP=284nt
GTGTGGAGCTGGAGCACCGTGAGGAAGAAGCGAGGTTCTTTTTAAGAGTTCAGCTGCGAGATATCAAACAAAGAATTACTCTGTACAAAG
CCAGAACACATATATCAAAGTAATCCTGAAGTATCAGAACAAAATAATAGGCTGTAACAGAGGAGGAAATGATTTTGAATAGCCTCTCTC
TGTGTTACCATAATAAGCTAATCCTGGCCCCAATGGTTCGGGTAGGGACTCTTCCAATGAGGCTGCTGGCCCTGGATTATGGAGCGGACA
TTGTTTACTGTGAGGTGGAATGGTTGAAAAATGAAGACATAATTGATCCCGTTGAAGATCGGAATTTTTATATTACTATTGATCACAACC
TCATCATAAAGCAGGCCCGACTCTCTGATACTGCAAATTACACCTGTGTTGCCAAAAACATTGTTGCCAAGAGGAAAAGTACAACTGCCA
CTGTCATAGTCTATGTCAACGGTGGCTGGTCCACCTGGACGGAGTGGTCTGTGTGTAACAGCCGCTGTGGACGAGGGTATCAGAAACGTA
CAAGGACTTGTACCAACCCGGCACCACTCAATGGGGGTGCCTTCTGTGAAGGGCAGAGTGTGCAGAAAATAGCCTGTACTACGTTATGCC
CAGTGGATGGCAGGTGGACGCCATGGAGCAAGTGGTCTACTTGTGGAACTGAGTGCACCCACTGGCGCAGGAGGGAGTGCACGGCGCCAG
CCCCCAAGAATGGAGGCAAGGACTGCGACGGCCTCGTCTTGCAATCCAAGAACTGCACTGATGGGCTTTGCATGCAGACTGCTCCTGATT
CAGATGATGTTGCTCTCTATGTTGGGATTGTGATAGCAGTGATCGTTTGCCTGGCGATCTCTGTAGTTGTGGCCTTGTTTGTGTATCGGA
AGAATCATCGTGACTTTGAGTCAGATATTATTGACTCTTCGGCACTCAATGGGGGCTTTCAGCCTGTGAACATCAAGGCAGCAAGACAAG
ATCTGCTGGCTGTACCCCCAGACCTCACGTCAGCTGCAGCCATGTACAGAGGACCTGTCTATGCCCTGCATGACGTCTCAGACAAAATCC
CAATGACCAACTCTCCAATTCTGGATCCACTGCCCAACCTGAAAATCAAAGTGTACAACACCTCAGGTGCTGTCACCCCCCAAGATGACC
TCTCTGAGTTTACGTCCAAGCTGTCCCCTCAGATGACCCAGTCGTTGTTGGAGAATGAAGCCCTCAGCCTGAAGAACCAGAGTCTAGCAA
GGCAGACTGATCCATCCTGTACCGCATTTGGCAGCTTCAACTCGCTGGGAGGTCACCTTATTGTTCCCAATTCAGGAGTCAGCTTGCTGA
TTCCCGCTGGGGCCATTCCCCAAGGGAGAGTCTACGAAATGTATGTGACTGTACACAGGAAAGAAACTATGAGGCCACCCATGGATGACT
CTCAGACACTTTTGACCCCTGTGGTGAGCTGTGGGCCCCCAGGAGCTCTGCTCACCCGCCCAGTCGTCCTCACTATGCATCACTGCGCAG
ACCCCAATACCGAGGACTGGAAAATACTGCTCAAGAACCAGGCAGCACAGGGACAGTGGGAGGATGTGGTGGTGGTCGGGGAGGAAAACT
TCACCACCCCCTGCTACATTCAGCTGGATGCAGAGGCCTGCCACATCCTCACAGAGAACCTCAGCACCTACGCCCTGGTAGGACATTCCA
CCACCAAAGCGGCTGCGAAGCGCCTCAAGCTGGCCATCTTTGGGCCCCTGTGCTGCTCCTCGCTGGAGTACAGCATCCGAGTCTACTGTC
TGGATGACACCCAGGATGCCCTGAAGGAAATTTTACATCTTGAGAGACAGATGGGAGGACAGCTCCTAGAAGAACCTAAGGCTCTTCATT
TTAAAGGCAGCACCCACAACCTGCGCCTGTCAATTCACGATATCGCCCATTCCCTCTGGAAGAGCAAATTGCTGGCTAAATATCAGGAAA
TTCCATTTTACCATGTTTGGAGTGGATCTCAAAGAAACCTGCACTGCACCTTCACTCTGGAAAGATTTAGCCTGAACACAGTGGAGCTGG
TTTGCAAACTCTGTGTGCGGCAGGTGGAAGGAGAAGGGCAGATCTTCCAGCTCAACTGCACCGTGTCAGAGGAACCTACTGGCATCGATT
TGCCGCTGCTGGATCCTGCGAACACCATCACCACGGTCACGGGGCCCAGTGCTTTCAGCATCCCTCTCCCTATCCGGCAGAAGCTCTGTA
GCAGCCTGGATGCCCCCCAGACGAGAGGCCATGACTGGAGGATGCTGGCCCATAAGCTGAACCTGGACAGGTACTTGAATTACTTTGCCA
CCAAATCCAGCCCAACTGGCGTAATCCTGGATCTTTGGGAAGCACAGAACTTCCCAGATGGAAACCTGAGCATGCTGGCAGCTGTCTTGG
AAGAAATGGGAAGACATGAAACGGTGGTGTCCTTAGCAGCAGAAGGGCAGTATTAACCACCATGCTGGAAGGGGAAATGAAGGACAAAAA
TGCACAGGGAGTCTGTGGCCGTCCAGGTGAATCACAGCTGAGGAGGAAATCCAGATGAGACCAATGCACTTCACAGGCAAGACTGCAGCA
GGAGCCAGAAGGAAAACAGATACAACTGCCCATGTACATGCCCACTTTACTCGGACATCATCACGGGAGTTAAGAAAAATTGTGTAAATT
TGTACCTTGAATTTAGCTATCAACCTAATTTTCCTCTTAGTTGGGCTGTATGCTGTGTGGTACAGGATCTTACAGTTTCCTAGGAAACGC
TTTTTATTGCTATCCAGATATATGGATAAACTTTCTTAACAAACCCAATTTCTACAAATGTTGTTTACATCAAATTGGACAGGGATGCAG
ACACTGTCCATGGCTCGTTCTATTTTTGTTCAAATCATTTGAAGTTGAAGCTGTGGACGGTTTGTTGTGTCTATTTCAGATTAGTAATTT
ACAGAGAAATCACAGACTTTTGCTACAAATCGTGTGCATCAAGTGTCTCAGATAATCCTCCCATCAGTGTTCTGTTTCTAGAACTTGTAG
AACCAGTGTTACTGTTTGTATCAGGGAAGTGGAGAATCTAAGTGTAAAAAAGAAATAACTAAGACTCCTATTCCTTGGAGGGACCCTTCT
GGTGCCCTTTGGGAATAAAGCTGTAGCACTGCAGGGAAGACAGTGATTCATGTTCAACCCCACAAACAAGCATTTTTTTCACAACATGTG
TGTTTGTTTGTAATATGCAATATGAAGTGTTTTTTTTTAAAGGTATTATTATTATTTACAGGTATTCTGGTAAAATGATTTTTTTAAATT
TCTATTTTTGTTAGCAGTGCTGTTTGTTAGTATTTGGTTATTGACTAGACCTGTCCCACCTTTTCACCTATCAAGGTGGGTGTGGTCATC
AGTTTAATTCAACATGCATCACTTCCTTGACCTTTTACCTTTCCCTTATTCCACCCCAGAAAGGTGATTGATAAATGCTGAATGGCTTTG
TCAGTCTGTTCCTTCAGCTTGCTCAGGCAGGGTCTTTCTTTCTCCTCTGAGGAGTCTTAAGGAGACGTGTTCTCTATTAAGTTCACTTAA
TATTGCCGTTGTGTGGCCCCACGTCGACTCCCTATGGTGCTCTACTCTAGAGGCAGTGTGGTTGGAGGAATGGACTCTAAACTGGAGATC
AAGAAACCAGTTCTCATTGTGGGTCTGTCACTGTCTTGTTGCGCCACCTTGAGAAAGTCATTTAACCACACGACCTCAGTGTCCTCACTA
GAAAGTGAAAGGGTGGGATTAGATCATCTCCAAGTTCTGAAATGCTCAACTTCCACCGTGATGCCTCCAGTCTCATTCATCAGTCTGAAG
ACCACAATGGACTCTGACCTGGATCATCATTTAAAAATCATCAGCTGGTCTTTTGCCCAGGCTATGTTACGCCTTTCAAGTAGTTCTGAC
AAGGAAGATGATTATTCTAACCAGCATTATGATGTTGTTTGTTTGGCCTGAGTCGCTCTGCATCATTGCATTATGCTGTTCACTGAGAGA
TGACATCCCTTTATTATCATTTTCTTAGCCTCTCTTGGGATGCCCCTGCCCCCAGCCTTCCTGACTGGTTGCAAATTCTGTTTTTTATTA
TTGTCTTGGCATCTTGATATCTAGACCACTCCTACAAGTTTATCTGGCAGTAGGAACTTGGTGCATTTTTTTCTACGCTACACCCCCCCA
CCCTTAATCTTTCTTTGCTGTCATAATATTCAGTAGCATTTATAAAAGCTGTCTAGTTAGCTCTTTAAAAACTTTTGTCCTGCAAAATGT
TTGTTAGTCAACACACTACTTTGTGTAAACAACTATTATGTTTCCTTGGGACCATCACAAGCTCTTTAACAAACACAAGGACTCAATTCA
TTCAGCAGGTGGGGATTAAAGAATCAAAGCCCAGTAGCAAAACCAAAACTGAAGAACAAGCAGACATGTGTATGAATCGGAACCTTTAGA
ACATGACTGTGGTTTACTTTTAGGCTGGAGGCACACAAGTTGCTGAACAGACTTGAATTATACATGTGCTTCCATCTTTCCATGTTTCCG
CTCCTATTTTGGTAGCATCTTGAGATTCCTTGATGCCTCCGCCATCCTCATCCCTGAGGAACTGCTGATACCTTGCTATGGAACCTCTTC
TTTCTTTCATGCTTTTTATTCCGTATCTTCTGTTTTGGACATACATACATATATTCTATAAAATCTCTCTCAGCCCACCCCCTGCATTAG
GATTTCCATATTTAAAATATTTGTACACTGACTGGGGAAGGGAGAGATTGCACTATAAACAAGTTCAGTGGATGTTTGTAGCAATGAGTA
AAACTGTATTCTAAATTAAAAATCAAATATATATACACGCAGTTATACACACACATTTTTTAAAAGGAGGAGGAGGAAAGAGAGCTATTG
TCCATTCCTACATTTTGAAATAAACTTGTCAAGATTACGCATCAGTACCAGGGTTGTGGAATCATCTATGGAAATCAAGAACTAGAATCT
GAACTGAATGGTCAAAGAAACTTCTATGCCTAGTGAAAACTAGAGGGGAGCAACTATGTAGCTATGAACATGAATCAATTCCATAACTGT
TACTAAAAACTTATTTTGACTAAAAAGTCACCAACACAGAACTATTGAACACAAACAGGAATTGTTTGTCTTACTGAAGTCACTGAGAAC
CCTTGGGGTTCACTTCAGATGCTTTTTTGGTTCAACTTCCCACCACCAGAAAAGGGAAAAGTGATTGATTTCGTGTGTGAGGTACTCATC
TGTCAGAACCCTTAATGTTTCCTATTAAGTGAATGACAACTTCCATACATACACTATTTATACCAAATAATTTTCACTACAAATTCTGAT
TTCCTTCTCCTTTGGAGTAAAGTAATAGCTGTTAGATTGCTTTCAAACTTAGAAGGTCCAGATATAACAGTTCATTTCATAGGAAGCCAC
TTCATCAACCATTCTATGTGATACATCCTGCTTCTTTCTACACCGCTGGAGAGGCAGTTTGGCTGGTTTCATTTGGATAGAAAAAACTAT
CATTTGTGCATGCTGCCATCTAGTGGTGTACAACACAATCTAACCTGAGTTTAATATTCACTAGAATGTGTTTGACGAAGGGAATGAAAA
CCTGTAGAGTTCAAGGACCTTTATGACAAACAGATGTAGGGAAATTTTCACTTCAAATTTATAATTTTCTTATTCTCACTTTTTTTTCAT
TTGCATCACTCATCTCAATATTAGGTCACTGTGAGCCCAGTACATCAACTCATTCATACACAACATATCTTCAGTTGCTTCTTGTAACAG
AACTATGTAAAATCTATATAAAACAGTCTTTGAAGAGTTGTCATTTTTAACACTTATGGTTTTCATTGGGGTTTGTATACTTTAAATCTC
CTTTTAGTTCCTTAATATTTATCTTTGGAAATGTAAGAAGTATCTGCTTAGAAAGAAATAAGTCTTATATATGCGAATGGAATACTATGT
CTAGGGAAGAGAAAATTGGGGTTGTTAATCAAAGGGAAGAAAGCAGCTTCTTTTCTGCTGAATTTGGGAATCCAAAGGCAGAGGTTTCAT
CCTGTTTTTATTTTCTTCTTATCACACTCTTTCAAGTTTCCTTAATGTATCTGGAAGGAATAGAAGTTGGATTCAGAATTGATAACTGGC
ATGGTGATGACAAACCTGTGTAACACCAAGGTTCTCACAGCTAACAGCTGTTTCACAAACGGCATCTTCCAAATGAACAGTCACCTCTGC
TATGCAGAAAACCCCCATCCTGCTGTGAGCAAGTTAGGCTCTTCAAGAACTGGACAACTTTTGGGTGAGGTGTTCAATATCAAACTGCAT
AATCATTAGCCATTTTCATATATACTATTTTATAGATTTAAGTCTCTCAACTATCAAAAAGTAGAGCGATTTTCAGGAGAAAAAAGTCGT
GGGGACTGAGTTCAGGACACCCTGAAACTATGCGACCAGTAATTTTTTTAAGGTATTTTTTCCTACAAGTAAGGTATCTGAAAAGTCAAC
GTTTTGAGGGTGGAATCAAGACTTTTCACTTCTCCTGGCAAAGAGCAACAAGGCTCTTGTCTCGTGTCCTTCTGTGTGTCTCTGTCAGGA
TCACAGCAGCTGTGCTCTTGGTCTGCTTACTCCTCTGTAATCCACGTATGCAGAAGGGAGTTAATAAGGTGATCACCATCTCCCCAGAAT
TCAAAGGTCTTTGCCTCTATAAGGTCTGCCCCTATGGGGCCAGGAAAATATAAACCTATATAAGGACTTGCAAGAGAGCATAAAGAAGGT
AGAAAAGGTTTACTTGTTGGGTTTTCAAGCCTTCAAGTTGAATGAGTCTTAGCTTTTGCTGGGCAGTTGTTCTGGACAAGTCATCAGTTT
CATGTGGAGAACTCAGTGTAAGCCCAAGGCTAATGAATGAGAGGGGTCCCATGGAAACACAGCTGAAATGAAATGGGACTTTATCCATCT
TCTTTGAGAATGGAAGAGCTTTTGTGAAGCAGTACATCATTGCTCAAGATAATGGTTGATAAGCATTAGATTTTATAGATCTAATAAGGA
AAATATTTTATTATCTCAAGTTAACAAAACATTTTTTTACCTCTCGAGTGCCTCATAGGACCAACTATTACTCTTTGGCTTTTATTTTTC
TTTTTGTATTATTTTTATATATTCTTTAACCTTGCTGAGCTAGTATTGACTGAAATCTTTAGAACTTTGCCTCTGGGCAATGAAGTAATG
TTTCTCTACCCTAAGATATCTATTTGTATAATCTCTGGCTGTAATGATCACTTTGGAAGATTTCCTTTGCATCTCTAATTATTTCTTTTT
AATGGAATAAGGCATAAGGGGGAATAAATATATTGTAACCAATGTTATGTAAACCCATATCCATACAGGCCAGGAAAGCCAAATGAAGTC
ATTTCCAGAATTCTAGTGTGAAAAACCTATTTTTGAAAAGTGGGGAGATGGCTTTGTGTAGAACTGGGTGGGTTTTCTCTGCAGACTAAG
TCTAGCCATGAGCTTCCAGATCCTTTAGTTTTATCAGCCTTGTGCTTACCCCATTTTCATAAATGCTACTTTAACAGCCAGTCTTCATAA
GTCATGGTTCCTAGGTTTTCCTGTCACCTCATTGTATTCATCTGTGGTAGGATATTAACGGGCTCATTCAACCAAATGTAATGTGTGCCT
CAGACCTATTTAGCATGGTTGGGGGGCATCAGCAGGACAAACCAACAGGTACTCCGCAAGTGTACTGGCACAGCAAGCCCACCAATTATT
AGCAGCTCTTCATCAGCCTGCTGTCTACTCAGACGCTTGCCTACTGAAGGGACCTGTCCAGAGATCTTCTGGAATCCCAGGTTGGGAATC
TCTGCAGAATGTCGTGACAGTTGTGGCCCAACTAGCTTCTGAGTAGAAACAAGGAAGCTACCCTGAGATATAGTCAGCTGCCCACCTGCC
ATAGTATTTGCTACTGAATGCCAGCCTTTTAACATACCATTTCAGATTTGTCCTTCAACAAAAATATAAATTGCAAGTCATACCATTTAA
GGGTCTTTTACAAATATGTCTAAATTGTGTGTCATTTTTAAGTTCCAAAGGTCTACTGGACTAAGTACTATCAGACCAGCTGTAGAACCT
GATGGCGCTGATCCGGGGTGGAATAACCCTCAGTACTGGTGTGTAGAAGATGAATTGTAGGCAGGTTTTGCTGATCAGCAGCCTAAGGAT
TGATGGGCTCTCTTTTGGCCTCTGATCCTGAGCACTATGGAGGCAGCATCAGAGAATGGGGACCTGAGCTACATAGGTTCTCAATGTTAA
AACAACTCTGTTCGGAGTGACATATAAGAGCAAGAAATCTACAGCTGGTGTAAAATACCTTTGCCTTTTCTATCCCGAAAGTAACAAATG
GCATCTGTACATGTAGGGGTAAAAACTCAGATGTCTACTCCTCCAGGCCATGGACAAGAAAAAGTACAGCAGTCAGAACAGTGGAACAAG
TGATTTGCATTCTCTTCTTCACGCTTTCCTAGATCTGCCATTGGTAGCGCAGCCCTCGCCCTCCAGACATAATGCATCGAGCCCAGTTGC
AGGGAACATCACTGTGTGTGTGTGATGTCATGGTGTTATATGTGTTGAGTTTAATGTTGAGCTGAAGCAAGTTGGTGACCTTCCTCTTTG
CTCTTTGTAAAGAAGACACCAATGTTTGTCAGAGAAAAATCCCCAGCAGTCGTGTTGAAGAGGCAGTGTCATCCACCTACTGTCCCCTTT
GGAACAGTTCAACTGCAGAAAGGTCGGATTGAGGTTTTGTGCTTTGTCGTTTTTCTTTTTTAAACAAAACATGACAACCTTGGCTTTTCC
GATATGGAACACTTTTGTTGTTGTGGAGTTCCCTCTTGCTGTATCTTCTATGCAATTCCTTTTCTAAAAAAACCCCCCGGCAGAGGCAGA
GTGCCCTCCGGATATCTGTCCGGCGCCTTGCTGAGTGGTGGAGGTGAGGGATACCAGCTCCGGGTGTGCCTCTTTTCTCTCCCTGGCTGC
CAATCCTGATTTTCCCTGCAGTCCCCTTGGTTTGTAAATTGCCTGCATTTATTCTGTCAGCCAACATGTACAAAATGTAAGAAAGAATTT

>24448_24448_4_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000432752_UNC5C_chr4_96171818_ENST00000453304_length(amino acids)=775AA_BP=42
MILNSLSLCYHNKLILAPMVRVGTLPMRLLALDYGADIVYCEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVA
KRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWR
RRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPV
NIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALS
LKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVV
LTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLE
YSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERF
SLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLD

--------------------------------------------------------------
>24448_24448_5_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000432752_UNC5C_chr4_96171818_ENST00000504962_length(transcript)=1136nt_BP=284nt
GTGTGGAGCTGGAGCACCGTGAGGAAGAAGCGAGGTTCTTTTTAAGAGTTCAGCTGCGAGATATCAAACAAAGAATTACTCTGTACAAAG
CCAGAACACATATATCAAAGTAATCCTGAAGTATCAGAACAAAATAATAGGCTGTAACAGAGGAGGAAATGATTTTGAATAGCCTCTCTC
TGTGTTACCATAATAAGCTAATCCTGGCCCCAATGGTTCGGGTAGGGACTCTTCCAATGAGGCTGCTGGCCCTGGATTATGGAGCGGACA
TTGTTTACTGTGAGGTGGAATGGTTGAAAAATGAAGACATAATTGATCCCGTTGAAGATCGGAATTTTTATATTACTATTGATCACAACC
TCATCATAAAGCAGGCCCGACTCTCTGATACTGCAAATTACACCTGTGTTGCCAAAAACATTGTTGCCAAGAGGAAAAGTACAACTGCCA
CTGTCATAGTCTATGGTCCTTGAGAAACAGCGGGCTCAAGATCACTCTGCTAGTCCTGTCTCTTAAAAGCAGGAGAGGAGATTTTCAGCT
GAAAGATGGCTTCCCTATACCAGAAGGAAAGTAACATTCTTATCCTCAAGGACAGGAAGTTGAGACCACGGGGAAGTTACGATCCAGATA
ATTCTGTATCGATCTTATTAAAATAACTCTTAATCTTCTTTTAGCCTTAACACATAATTGACTTTTTCATAACTTGCTACTCTTTGTCCA
ATTCAATATATAAGCATTCAACTATAACTGCATCTTTGGGTCTTCATTTTCTTAGGCCATGTAAAAGTTATATTAAGTAAATTTACATGT
TTTTCTCCTGTTGATTTGTGTTACACCAATTTAATTCTTAGGCCCAGCCAAAAAAAAAATCCTAAAAGAGTGGAAGTAAAATATTGCCTA
CCCCACAGTACCATTCAGATGGATGTGTGTTTATGAGAAGAGAAACCACTATGCTGTTCCAAAGGATGAATGTAGTGCTGCTTTAAAAAT
GTCATTTTAATTACAGGAAAAATGGCACAAAAATTTTTTGATCCTCTGATTACCCTGAGGTTTAATTTCCTAGTCCAGATAATGGCTGTG

>24448_24448_5_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000432752_UNC5C_chr4_96171818_ENST00000504962_length(amino acids)=104AA_BP=42
MILNSLSLCYHNKLILAPMVRVGTLPMRLLALDYGADIVYCEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVA

--------------------------------------------------------------
>24448_24448_6_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000432752_UNC5C_chr4_96171818_ENST00000506749_length(transcript)=1561nt_BP=284nt
GTGTGGAGCTGGAGCACCGTGAGGAAGAAGCGAGGTTCTTTTTAAGAGTTCAGCTGCGAGATATCAAACAAAGAATTACTCTGTACAAAG
CCAGAACACATATATCAAAGTAATCCTGAAGTATCAGAACAAAATAATAGGCTGTAACAGAGGAGGAAATGATTTTGAATAGCCTCTCTC
TGTGTTACCATAATAAGCTAATCCTGGCCCCAATGGTTCGGGTAGGGACTCTTCCAATGAGGCTGCTGGCCCTGGATTATGGAGCGGACA
TTGTTTACTGTGAGGTGGAATGGTTGAAAAATGAAGACATAATTGATCCCGTTGAAGATCGGAATTTTTATATTACTATTGATCACAACC
TCATCATAAAGCAGGCCCGACTCTCTGATACTGCAAATTACACCTGTGTTGCCAAAAACATTGTTGCCAAGAGGAAAAGTACAACTGCCA
CTGTCATAGTCTATGTCAACGGTGGCTGGTCCACCTGGACGGAGTGGTCTGTGTGTAACAGCCGCTGTGGACGAGGGTATCAGAAACGTA
CAAGGACTTGTACCAACCCGGCACCACTCAATGGGGGTGCCTTCTGTGAAGGGCAGAGTGTGCAGAAAATAGCCTGTACTACGTTATGCC
CAGTGGATGGCAGGTGGACGCCATGGAGCAAGTGGTCTACTTGTGGAACTGAGTGCACCCACTGGCGCAGGAGGGAGTGCACGGCGCCAG
CCCCCAAGAATGGAGGCAAGGACTGCGACGGCCTCGTCTTGCAATCCAAGAACTGCACTGATGGGCTTTGCATGCAGAGTTTCATTTATC
CCATTTCAACTGAACAGAGAACCCAGAATGAATATGGATTTTCTTCTGCTCCTGATTCAGATGATGTTGCTCTCTATGTTGGGATTGTGA
TAGCAGTGATCGTTTGCCTGGCGATCTCTGTAGTTGTGGCCTTGTTTGTGTATCGGAAGAATCATCGTGACTTTGAGTCAGATATTATTG
ACTCTTCGGCACTCAATGGGGGCTTTCAGCCTGTGAACATCAAGGCAGCAAGACAAGATCTGCTGGCTGTACCCCCAGACCTCACGTCAG
CTGCAGCCATGTACAGAGGACCTGTCTATGCCCTGCATGACGTCTCAGACAAAATCCCAATGACCAACTCTCCAATTCTGGATCCACTGC
CCAACCTGAAAATCAAAGTGTACAACACCTCAGGTGCTGTCACCCCCCAAGATGACCTCTCTGAGTTTACGTCCAAGCTGTCCCCTCAGA
TGACCCAGTCGTTGTTGGAGAATGAAGCCCTCAGCCTGAAGAACCAGAGTCTAGCAAGGCAGACTGATCCATCCTGTACCGCATTTGGCA
GCTTCAACTCGCTGGGAGGTCACCTTATTGTTCCCAATTCAGGAGTCAGCTTGCTGATTCCCGCTGGGGCCATTCCCCAAGGGAGAGTCT
ACGAAATGTATGTGACTGTACACAGGAAAGAAACTATGAGGTAAATATGCTTTTTCTGGTGCACTGACTTTACCAATGTCTAACTTGGAG

>24448_24448_6_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000432752_UNC5C_chr4_96171818_ENST00000506749_length(amino acids)=441AA_BP=42
MILNSLSLCYHNKLILAPMVRVGTLPMRLLALDYGADIVYCEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVA
KRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWR
RRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQSFIYPISTEQRTQNEYGFSSAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHR
DFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEF

--------------------------------------------------------------
>24448_24448_7_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000565263_UNC5C_chr4_96171818_ENST00000453304_length(transcript)=9552nt_BP=620nt
TGAGGCGCGCCGGCTGGTTCAACTCCGGCCGCCGCGCCGAAACCAGCAGCGGTCCGGGTCGAACCAGCACCGGCCTCGGGAGGTTCCGCC
GCCTGCTCTGCCGCTGTTCCAACTGCCGCTGTAGAGCCACTGGGATGCGCACCACCGGCAGGGGTTCGTCGGGACTGCGGACCGTGAGGC
CCCGTCGCGGCGCCAGGAGCAACCGAGTCACGAGGGAAAAGAGCCGCACCGGCCGCGTTAGAGCCATGTTTCCCTTAGTGCGGGAGAAGC
GCACATCAGTGACGTCACGGACGCGCCGCGACCTCGCGTACGGTGGCTGGCGAGGCTCAGTACGGTGTGTGGAGCTGGAGCACCGTGAGG
AAGAAGCGAGGTTCTTTTTAAGAGTTCAGCTGCGAGATATCAAACAAAGAATTACTCTGTACAAAGCCAGAACACATATATCAAAGTAAT
CCTGAAGTATCAGAACAAAATAATAGGCTGTAACAGAGGAGGAAATGATTTTGAATAGCCTCTCTCTGTGTTACCATAATAAGCTAATCC
TGGCCCCAATGGTTCGGGTAGGGACTCTTCCAATGAGGCTGCTGGCCCTGGATTATGGAGCGGACATTGTTTACTGTGAGGTGGAATGGT
TGAAAAATGAAGACATAATTGATCCCGTTGAAGATCGGAATTTTTATATTACTATTGATCACAACCTCATCATAAAGCAGGCCCGACTCT
CTGATACTGCAAATTACACCTGTGTTGCCAAAAACATTGTTGCCAAGAGGAAAAGTACAACTGCCACTGTCATAGTCTATGTCAACGGTG
GCTGGTCCACCTGGACGGAGTGGTCTGTGTGTAACAGCCGCTGTGGACGAGGGTATCAGAAACGTACAAGGACTTGTACCAACCCGGCAC
CACTCAATGGGGGTGCCTTCTGTGAAGGGCAGAGTGTGCAGAAAATAGCCTGTACTACGTTATGCCCAGTGGATGGCAGGTGGACGCCAT
GGAGCAAGTGGTCTACTTGTGGAACTGAGTGCACCCACTGGCGCAGGAGGGAGTGCACGGCGCCAGCCCCCAAGAATGGAGGCAAGGACT
GCGACGGCCTCGTCTTGCAATCCAAGAACTGCACTGATGGGCTTTGCATGCAGACTGCTCCTGATTCAGATGATGTTGCTCTCTATGTTG
GGATTGTGATAGCAGTGATCGTTTGCCTGGCGATCTCTGTAGTTGTGGCCTTGTTTGTGTATCGGAAGAATCATCGTGACTTTGAGTCAG
ATATTATTGACTCTTCGGCACTCAATGGGGGCTTTCAGCCTGTGAACATCAAGGCAGCAAGACAAGATCTGCTGGCTGTACCCCCAGACC
TCACGTCAGCTGCAGCCATGTACAGAGGACCTGTCTATGCCCTGCATGACGTCTCAGACAAAATCCCAATGACCAACTCTCCAATTCTGG
ATCCACTGCCCAACCTGAAAATCAAAGTGTACAACACCTCAGGTGCTGTCACCCCCCAAGATGACCTCTCTGAGTTTACGTCCAAGCTGT
CCCCTCAGATGACCCAGTCGTTGTTGGAGAATGAAGCCCTCAGCCTGAAGAACCAGAGTCTAGCAAGGCAGACTGATCCATCCTGTACCG
CATTTGGCAGCTTCAACTCGCTGGGAGGTCACCTTATTGTTCCCAATTCAGGAGTCAGCTTGCTGATTCCCGCTGGGGCCATTCCCCAAG
GGAGAGTCTACGAAATGTATGTGACTGTACACAGGAAAGAAACTATGAGGCCACCCATGGATGACTCTCAGACACTTTTGACCCCTGTGG
TGAGCTGTGGGCCCCCAGGAGCTCTGCTCACCCGCCCAGTCGTCCTCACTATGCATCACTGCGCAGACCCCAATACCGAGGACTGGAAAA
TACTGCTCAAGAACCAGGCAGCACAGGGACAGTGGGAGGATGTGGTGGTGGTCGGGGAGGAAAACTTCACCACCCCCTGCTACATTCAGC
TGGATGCAGAGGCCTGCCACATCCTCACAGAGAACCTCAGCACCTACGCCCTGGTAGGACATTCCACCACCAAAGCGGCTGCGAAGCGCC
TCAAGCTGGCCATCTTTGGGCCCCTGTGCTGCTCCTCGCTGGAGTACAGCATCCGAGTCTACTGTCTGGATGACACCCAGGATGCCCTGA
AGGAAATTTTACATCTTGAGAGACAGATGGGAGGACAGCTCCTAGAAGAACCTAAGGCTCTTCATTTTAAAGGCAGCACCCACAACCTGC
GCCTGTCAATTCACGATATCGCCCATTCCCTCTGGAAGAGCAAATTGCTGGCTAAATATCAGGAAATTCCATTTTACCATGTTTGGAGTG
GATCTCAAAGAAACCTGCACTGCACCTTCACTCTGGAAAGATTTAGCCTGAACACAGTGGAGCTGGTTTGCAAACTCTGTGTGCGGCAGG
TGGAAGGAGAAGGGCAGATCTTCCAGCTCAACTGCACCGTGTCAGAGGAACCTACTGGCATCGATTTGCCGCTGCTGGATCCTGCGAACA
CCATCACCACGGTCACGGGGCCCAGTGCTTTCAGCATCCCTCTCCCTATCCGGCAGAAGCTCTGTAGCAGCCTGGATGCCCCCCAGACGA
GAGGCCATGACTGGAGGATGCTGGCCCATAAGCTGAACCTGGACAGGTACTTGAATTACTTTGCCACCAAATCCAGCCCAACTGGCGTAA
TCCTGGATCTTTGGGAAGCACAGAACTTCCCAGATGGAAACCTGAGCATGCTGGCAGCTGTCTTGGAAGAAATGGGAAGACATGAAACGG
TGGTGTCCTTAGCAGCAGAAGGGCAGTATTAACCACCATGCTGGAAGGGGAAATGAAGGACAAAAATGCACAGGGAGTCTGTGGCCGTCC
AGGTGAATCACAGCTGAGGAGGAAATCCAGATGAGACCAATGCACTTCACAGGCAAGACTGCAGCAGGAGCCAGAAGGAAAACAGATACA
ACTGCCCATGTACATGCCCACTTTACTCGGACATCATCACGGGAGTTAAGAAAAATTGTGTAAATTTGTACCTTGAATTTAGCTATCAAC
CTAATTTTCCTCTTAGTTGGGCTGTATGCTGTGTGGTACAGGATCTTACAGTTTCCTAGGAAACGCTTTTTATTGCTATCCAGATATATG
GATAAACTTTCTTAACAAACCCAATTTCTACAAATGTTGTTTACATCAAATTGGACAGGGATGCAGACACTGTCCATGGCTCGTTCTATT
TTTGTTCAAATCATTTGAAGTTGAAGCTGTGGACGGTTTGTTGTGTCTATTTCAGATTAGTAATTTACAGAGAAATCACAGACTTTTGCT
ACAAATCGTGTGCATCAAGTGTCTCAGATAATCCTCCCATCAGTGTTCTGTTTCTAGAACTTGTAGAACCAGTGTTACTGTTTGTATCAG
GGAAGTGGAGAATCTAAGTGTAAAAAAGAAATAACTAAGACTCCTATTCCTTGGAGGGACCCTTCTGGTGCCCTTTGGGAATAAAGCTGT
AGCACTGCAGGGAAGACAGTGATTCATGTTCAACCCCACAAACAAGCATTTTTTTCACAACATGTGTGTTTGTTTGTAATATGCAATATG
AAGTGTTTTTTTTTAAAGGTATTATTATTATTTACAGGTATTCTGGTAAAATGATTTTTTTAAATTTCTATTTTTGTTAGCAGTGCTGTT
TGTTAGTATTTGGTTATTGACTAGACCTGTCCCACCTTTTCACCTATCAAGGTGGGTGTGGTCATCAGTTTAATTCAACATGCATCACTT
CCTTGACCTTTTACCTTTCCCTTATTCCACCCCAGAAAGGTGATTGATAAATGCTGAATGGCTTTGTCAGTCTGTTCCTTCAGCTTGCTC
AGGCAGGGTCTTTCTTTCTCCTCTGAGGAGTCTTAAGGAGACGTGTTCTCTATTAAGTTCACTTAATATTGCCGTTGTGTGGCCCCACGT
CGACTCCCTATGGTGCTCTACTCTAGAGGCAGTGTGGTTGGAGGAATGGACTCTAAACTGGAGATCAAGAAACCAGTTCTCATTGTGGGT
CTGTCACTGTCTTGTTGCGCCACCTTGAGAAAGTCATTTAACCACACGACCTCAGTGTCCTCACTAGAAAGTGAAAGGGTGGGATTAGAT
CATCTCCAAGTTCTGAAATGCTCAACTTCCACCGTGATGCCTCCAGTCTCATTCATCAGTCTGAAGACCACAATGGACTCTGACCTGGAT
CATCATTTAAAAATCATCAGCTGGTCTTTTGCCCAGGCTATGTTACGCCTTTCAAGTAGTTCTGACAAGGAAGATGATTATTCTAACCAG
CATTATGATGTTGTTTGTTTGGCCTGAGTCGCTCTGCATCATTGCATTATGCTGTTCACTGAGAGATGACATCCCTTTATTATCATTTTC
TTAGCCTCTCTTGGGATGCCCCTGCCCCCAGCCTTCCTGACTGGTTGCAAATTCTGTTTTTTATTATTGTCTTGGCATCTTGATATCTAG
ACCACTCCTACAAGTTTATCTGGCAGTAGGAACTTGGTGCATTTTTTTCTACGCTACACCCCCCCACCCTTAATCTTTCTTTGCTGTCAT
AATATTCAGTAGCATTTATAAAAGCTGTCTAGTTAGCTCTTTAAAAACTTTTGTCCTGCAAAATGTTTGTTAGTCAACACACTACTTTGT
GTAAACAACTATTATGTTTCCTTGGGACCATCACAAGCTCTTTAACAAACACAAGGACTCAATTCATTCAGCAGGTGGGGATTAAAGAAT
CAAAGCCCAGTAGCAAAACCAAAACTGAAGAACAAGCAGACATGTGTATGAATCGGAACCTTTAGAACATGACTGTGGTTTACTTTTAGG
CTGGAGGCACACAAGTTGCTGAACAGACTTGAATTATACATGTGCTTCCATCTTTCCATGTTTCCGCTCCTATTTTGGTAGCATCTTGAG
ATTCCTTGATGCCTCCGCCATCCTCATCCCTGAGGAACTGCTGATACCTTGCTATGGAACCTCTTCTTTCTTTCATGCTTTTTATTCCGT
ATCTTCTGTTTTGGACATACATACATATATTCTATAAAATCTCTCTCAGCCCACCCCCTGCATTAGGATTTCCATATTTAAAATATTTGT
ACACTGACTGGGGAAGGGAGAGATTGCACTATAAACAAGTTCAGTGGATGTTTGTAGCAATGAGTAAAACTGTATTCTAAATTAAAAATC
AAATATATATACACGCAGTTATACACACACATTTTTTAAAAGGAGGAGGAGGAAAGAGAGCTATTGTCCATTCCTACATTTTGAAATAAA
CTTGTCAAGATTACGCATCAGTACCAGGGTTGTGGAATCATCTATGGAAATCAAGAACTAGAATCTGAACTGAATGGTCAAAGAAACTTC
TATGCCTAGTGAAAACTAGAGGGGAGCAACTATGTAGCTATGAACATGAATCAATTCCATAACTGTTACTAAAAACTTATTTTGACTAAA
AAGTCACCAACACAGAACTATTGAACACAAACAGGAATTGTTTGTCTTACTGAAGTCACTGAGAACCCTTGGGGTTCACTTCAGATGCTT
TTTTGGTTCAACTTCCCACCACCAGAAAAGGGAAAAGTGATTGATTTCGTGTGTGAGGTACTCATCTGTCAGAACCCTTAATGTTTCCTA
TTAAGTGAATGACAACTTCCATACATACACTATTTATACCAAATAATTTTCACTACAAATTCTGATTTCCTTCTCCTTTGGAGTAAAGTA
ATAGCTGTTAGATTGCTTTCAAACTTAGAAGGTCCAGATATAACAGTTCATTTCATAGGAAGCCACTTCATCAACCATTCTATGTGATAC
ATCCTGCTTCTTTCTACACCGCTGGAGAGGCAGTTTGGCTGGTTTCATTTGGATAGAAAAAACTATCATTTGTGCATGCTGCCATCTAGT
GGTGTACAACACAATCTAACCTGAGTTTAATATTCACTAGAATGTGTTTGACGAAGGGAATGAAAACCTGTAGAGTTCAAGGACCTTTAT
GACAAACAGATGTAGGGAAATTTTCACTTCAAATTTATAATTTTCTTATTCTCACTTTTTTTTCATTTGCATCACTCATCTCAATATTAG
GTCACTGTGAGCCCAGTACATCAACTCATTCATACACAACATATCTTCAGTTGCTTCTTGTAACAGAACTATGTAAAATCTATATAAAAC
AGTCTTTGAAGAGTTGTCATTTTTAACACTTATGGTTTTCATTGGGGTTTGTATACTTTAAATCTCCTTTTAGTTCCTTAATATTTATCT
TTGGAAATGTAAGAAGTATCTGCTTAGAAAGAAATAAGTCTTATATATGCGAATGGAATACTATGTCTAGGGAAGAGAAAATTGGGGTTG
TTAATCAAAGGGAAGAAAGCAGCTTCTTTTCTGCTGAATTTGGGAATCCAAAGGCAGAGGTTTCATCCTGTTTTTATTTTCTTCTTATCA
CACTCTTTCAAGTTTCCTTAATGTATCTGGAAGGAATAGAAGTTGGATTCAGAATTGATAACTGGCATGGTGATGACAAACCTGTGTAAC
ACCAAGGTTCTCACAGCTAACAGCTGTTTCACAAACGGCATCTTCCAAATGAACAGTCACCTCTGCTATGCAGAAAACCCCCATCCTGCT
GTGAGCAAGTTAGGCTCTTCAAGAACTGGACAACTTTTGGGTGAGGTGTTCAATATCAAACTGCATAATCATTAGCCATTTTCATATATA
CTATTTTATAGATTTAAGTCTCTCAACTATCAAAAAGTAGAGCGATTTTCAGGAGAAAAAAGTCGTGGGGACTGAGTTCAGGACACCCTG
AAACTATGCGACCAGTAATTTTTTTAAGGTATTTTTTCCTACAAGTAAGGTATCTGAAAAGTCAACGTTTTGAGGGTGGAATCAAGACTT
TTCACTTCTCCTGGCAAAGAGCAACAAGGCTCTTGTCTCGTGTCCTTCTGTGTGTCTCTGTCAGGATCACAGCAGCTGTGCTCTTGGTCT
GCTTACTCCTCTGTAATCCACGTATGCAGAAGGGAGTTAATAAGGTGATCACCATCTCCCCAGAATTCAAAGGTCTTTGCCTCTATAAGG
TCTGCCCCTATGGGGCCAGGAAAATATAAACCTATATAAGGACTTGCAAGAGAGCATAAAGAAGGTAGAAAAGGTTTACTTGTTGGGTTT
TCAAGCCTTCAAGTTGAATGAGTCTTAGCTTTTGCTGGGCAGTTGTTCTGGACAAGTCATCAGTTTCATGTGGAGAACTCAGTGTAAGCC
CAAGGCTAATGAATGAGAGGGGTCCCATGGAAACACAGCTGAAATGAAATGGGACTTTATCCATCTTCTTTGAGAATGGAAGAGCTTTTG
TGAAGCAGTACATCATTGCTCAAGATAATGGTTGATAAGCATTAGATTTTATAGATCTAATAAGGAAAATATTTTATTATCTCAAGTTAA
CAAAACATTTTTTTACCTCTCGAGTGCCTCATAGGACCAACTATTACTCTTTGGCTTTTATTTTTCTTTTTGTATTATTTTTATATATTC
TTTAACCTTGCTGAGCTAGTATTGACTGAAATCTTTAGAACTTTGCCTCTGGGCAATGAAGTAATGTTTCTCTACCCTAAGATATCTATT
TGTATAATCTCTGGCTGTAATGATCACTTTGGAAGATTTCCTTTGCATCTCTAATTATTTCTTTTTAATGGAATAAGGCATAAGGGGGAA
TAAATATATTGTAACCAATGTTATGTAAACCCATATCCATACAGGCCAGGAAAGCCAAATGAAGTCATTTCCAGAATTCTAGTGTGAAAA
ACCTATTTTTGAAAAGTGGGGAGATGGCTTTGTGTAGAACTGGGTGGGTTTTCTCTGCAGACTAAGTCTAGCCATGAGCTTCCAGATCCT
TTAGTTTTATCAGCCTTGTGCTTACCCCATTTTCATAAATGCTACTTTAACAGCCAGTCTTCATAAGTCATGGTTCCTAGGTTTTCCTGT
CACCTCATTGTATTCATCTGTGGTAGGATATTAACGGGCTCATTCAACCAAATGTAATGTGTGCCTCAGACCTATTTAGCATGGTTGGGG
GGCATCAGCAGGACAAACCAACAGGTACTCCGCAAGTGTACTGGCACAGCAAGCCCACCAATTATTAGCAGCTCTTCATCAGCCTGCTGT
CTACTCAGACGCTTGCCTACTGAAGGGACCTGTCCAGAGATCTTCTGGAATCCCAGGTTGGGAATCTCTGCAGAATGTCGTGACAGTTGT
GGCCCAACTAGCTTCTGAGTAGAAACAAGGAAGCTACCCTGAGATATAGTCAGCTGCCCACCTGCCATAGTATTTGCTACTGAATGCCAG
CCTTTTAACATACCATTTCAGATTTGTCCTTCAACAAAAATATAAATTGCAAGTCATACCATTTAAGGGTCTTTTACAAATATGTCTAAA
TTGTGTGTCATTTTTAAGTTCCAAAGGTCTACTGGACTAAGTACTATCAGACCAGCTGTAGAACCTGATGGCGCTGATCCGGGGTGGAAT
AACCCTCAGTACTGGTGTGTAGAAGATGAATTGTAGGCAGGTTTTGCTGATCAGCAGCCTAAGGATTGATGGGCTCTCTTTTGGCCTCTG
ATCCTGAGCACTATGGAGGCAGCATCAGAGAATGGGGACCTGAGCTACATAGGTTCTCAATGTTAAAACAACTCTGTTCGGAGTGACATA
TAAGAGCAAGAAATCTACAGCTGGTGTAAAATACCTTTGCCTTTTCTATCCCGAAAGTAACAAATGGCATCTGTACATGTAGGGGTAAAA
ACTCAGATGTCTACTCCTCCAGGCCATGGACAAGAAAAAGTACAGCAGTCAGAACAGTGGAACAAGTGATTTGCATTCTCTTCTTCACGC
TTTCCTAGATCTGCCATTGGTAGCGCAGCCCTCGCCCTCCAGACATAATGCATCGAGCCCAGTTGCAGGGAACATCACTGTGTGTGTGTG
ATGTCATGGTGTTATATGTGTTGAGTTTAATGTTGAGCTGAAGCAAGTTGGTGACCTTCCTCTTTGCTCTTTGTAAAGAAGACACCAATG
TTTGTCAGAGAAAAATCCCCAGCAGTCGTGTTGAAGAGGCAGTGTCATCCACCTACTGTCCCCTTTGGAACAGTTCAACTGCAGAAAGGT
CGGATTGAGGTTTTGTGCTTTGTCGTTTTTCTTTTTTAAACAAAACATGACAACCTTGGCTTTTCCGATATGGAACACTTTTGTTGTTGT
GGAGTTCCCTCTTGCTGTATCTTCTATGCAATTCCTTTTCTAAAAAAACCCCCCGGCAGAGGCAGAGTGCCCTCCGGATATCTGTCCGGC
GCCTTGCTGAGTGGTGGAGGTGAGGGATACCAGCTCCGGGTGTGCCTCTTTTCTCTCCCTGGCTGCCAATCCTGATTTTCCCTGCAGTCC
CCTTGGTTTGTAAATTGCCTGCATTTATTCTGTCAGCCAACATGTACAAAATGTAAGAAAGAATTTTTAAACAGGTAATAAATTATATTT

>24448_24448_7_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000565263_UNC5C_chr4_96171818_ENST00000453304_length(amino acids)=775AA_BP=42
MILNSLSLCYHNKLILAPMVRVGTLPMRLLALDYGADIVYCEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVA
KRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWR
RRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPV
NIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALS
LKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVV
LTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLE
YSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERF
SLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLD

--------------------------------------------------------------
>24448_24448_8_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000565263_UNC5C_chr4_96171818_ENST00000504962_length(transcript)=1472nt_BP=620nt
TGAGGCGCGCCGGCTGGTTCAACTCCGGCCGCCGCGCCGAAACCAGCAGCGGTCCGGGTCGAACCAGCACCGGCCTCGGGAGGTTCCGCC
GCCTGCTCTGCCGCTGTTCCAACTGCCGCTGTAGAGCCACTGGGATGCGCACCACCGGCAGGGGTTCGTCGGGACTGCGGACCGTGAGGC
CCCGTCGCGGCGCCAGGAGCAACCGAGTCACGAGGGAAAAGAGCCGCACCGGCCGCGTTAGAGCCATGTTTCCCTTAGTGCGGGAGAAGC
GCACATCAGTGACGTCACGGACGCGCCGCGACCTCGCGTACGGTGGCTGGCGAGGCTCAGTACGGTGTGTGGAGCTGGAGCACCGTGAGG
AAGAAGCGAGGTTCTTTTTAAGAGTTCAGCTGCGAGATATCAAACAAAGAATTACTCTGTACAAAGCCAGAACACATATATCAAAGTAAT
CCTGAAGTATCAGAACAAAATAATAGGCTGTAACAGAGGAGGAAATGATTTTGAATAGCCTCTCTCTGTGTTACCATAATAAGCTAATCC
TGGCCCCAATGGTTCGGGTAGGGACTCTTCCAATGAGGCTGCTGGCCCTGGATTATGGAGCGGACATTGTTTACTGTGAGGTGGAATGGT
TGAAAAATGAAGACATAATTGATCCCGTTGAAGATCGGAATTTTTATATTACTATTGATCACAACCTCATCATAAAGCAGGCCCGACTCT
CTGATACTGCAAATTACACCTGTGTTGCCAAAAACATTGTTGCCAAGAGGAAAAGTACAACTGCCACTGTCATAGTCTATGGTCCTTGAG
AAACAGCGGGCTCAAGATCACTCTGCTAGTCCTGTCTCTTAAAAGCAGGAGAGGAGATTTTCAGCTGAAAGATGGCTTCCCTATACCAGA
AGGAAAGTAACATTCTTATCCTCAAGGACAGGAAGTTGAGACCACGGGGAAGTTACGATCCAGATAATTCTGTATCGATCTTATTAAAAT
AACTCTTAATCTTCTTTTAGCCTTAACACATAATTGACTTTTTCATAACTTGCTACTCTTTGTCCAATTCAATATATAAGCATTCAACTA
TAACTGCATCTTTGGGTCTTCATTTTCTTAGGCCATGTAAAAGTTATATTAAGTAAATTTACATGTTTTTCTCCTGTTGATTTGTGTTAC
ACCAATTTAATTCTTAGGCCCAGCCAAAAAAAAAATCCTAAAAGAGTGGAAGTAAAATATTGCCTACCCCACAGTACCATTCAGATGGAT
GTGTGTTTATGAGAAGAGAAACCACTATGCTGTTCCAAAGGATGAATGTAGTGCTGCTTTAAAAATGTCATTTTAATTACAGGAAAAATG
GCACAAAAATTTTTTGATCCTCTGATTACCCTGAGGTTTAATTTCCTAGTCCAGATAATGGCTGTGTTGAATTGTATGCAATTGCCTTTC

>24448_24448_8_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000565263_UNC5C_chr4_96171818_ENST00000504962_length(amino acids)=118AA_BP=
MLCRCSNCRCRATGMRTTGRGSSGLRTVRPRRGARSNRVTREKSRTGRVRAMFPLVREKRTSVTSRTRRDLAYGGWRGSVRCVELEHREE

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>24448_24448_9_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000565263_UNC5C_chr4_96171818_ENST00000506749_length(transcript)=1897nt_BP=620nt
TGAGGCGCGCCGGCTGGTTCAACTCCGGCCGCCGCGCCGAAACCAGCAGCGGTCCGGGTCGAACCAGCACCGGCCTCGGGAGGTTCCGCC
GCCTGCTCTGCCGCTGTTCCAACTGCCGCTGTAGAGCCACTGGGATGCGCACCACCGGCAGGGGTTCGTCGGGACTGCGGACCGTGAGGC
CCCGTCGCGGCGCCAGGAGCAACCGAGTCACGAGGGAAAAGAGCCGCACCGGCCGCGTTAGAGCCATGTTTCCCTTAGTGCGGGAGAAGC
GCACATCAGTGACGTCACGGACGCGCCGCGACCTCGCGTACGGTGGCTGGCGAGGCTCAGTACGGTGTGTGGAGCTGGAGCACCGTGAGG
AAGAAGCGAGGTTCTTTTTAAGAGTTCAGCTGCGAGATATCAAACAAAGAATTACTCTGTACAAAGCCAGAACACATATATCAAAGTAAT
CCTGAAGTATCAGAACAAAATAATAGGCTGTAACAGAGGAGGAAATGATTTTGAATAGCCTCTCTCTGTGTTACCATAATAAGCTAATCC
TGGCCCCAATGGTTCGGGTAGGGACTCTTCCAATGAGGCTGCTGGCCCTGGATTATGGAGCGGACATTGTTTACTGTGAGGTGGAATGGT
TGAAAAATGAAGACATAATTGATCCCGTTGAAGATCGGAATTTTTATATTACTATTGATCACAACCTCATCATAAAGCAGGCCCGACTCT
CTGATACTGCAAATTACACCTGTGTTGCCAAAAACATTGTTGCCAAGAGGAAAAGTACAACTGCCACTGTCATAGTCTATGTCAACGGTG
GCTGGTCCACCTGGACGGAGTGGTCTGTGTGTAACAGCCGCTGTGGACGAGGGTATCAGAAACGTACAAGGACTTGTACCAACCCGGCAC
CACTCAATGGGGGTGCCTTCTGTGAAGGGCAGAGTGTGCAGAAAATAGCCTGTACTACGTTATGCCCAGTGGATGGCAGGTGGACGCCAT
GGAGCAAGTGGTCTACTTGTGGAACTGAGTGCACCCACTGGCGCAGGAGGGAGTGCACGGCGCCAGCCCCCAAGAATGGAGGCAAGGACT
GCGACGGCCTCGTCTTGCAATCCAAGAACTGCACTGATGGGCTTTGCATGCAGAGTTTCATTTATCCCATTTCAACTGAACAGAGAACCC
AGAATGAATATGGATTTTCTTCTGCTCCTGATTCAGATGATGTTGCTCTCTATGTTGGGATTGTGATAGCAGTGATCGTTTGCCTGGCGA
TCTCTGTAGTTGTGGCCTTGTTTGTGTATCGGAAGAATCATCGTGACTTTGAGTCAGATATTATTGACTCTTCGGCACTCAATGGGGGCT
TTCAGCCTGTGAACATCAAGGCAGCAAGACAAGATCTGCTGGCTGTACCCCCAGACCTCACGTCAGCTGCAGCCATGTACAGAGGACCTG
TCTATGCCCTGCATGACGTCTCAGACAAAATCCCAATGACCAACTCTCCAATTCTGGATCCACTGCCCAACCTGAAAATCAAAGTGTACA
ACACCTCAGGTGCTGTCACCCCCCAAGATGACCTCTCTGAGTTTACGTCCAAGCTGTCCCCTCAGATGACCCAGTCGTTGTTGGAGAATG
AAGCCCTCAGCCTGAAGAACCAGAGTCTAGCAAGGCAGACTGATCCATCCTGTACCGCATTTGGCAGCTTCAACTCGCTGGGAGGTCACC
TTATTGTTCCCAATTCAGGAGTCAGCTTGCTGATTCCCGCTGGGGCCATTCCCCAAGGGAGAGTCTACGAAATGTATGTGACTGTACACA
GGAAAGAAACTATGAGGTAAATATGCTTTTTCTGGTGCACTGACTTTACCAATGTCTAACTTGGAGGAGAATTGTACAATAGACACAATA

>24448_24448_9_DUS2-UNC5C_DUS2_chr16_68072052_ENST00000565263_UNC5C_chr4_96171818_ENST00000506749_length(amino acids)=441AA_BP=42
MILNSLSLCYHNKLILAPMVRVGTLPMRLLALDYGADIVYCEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVA
KRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWR
RRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQSFIYPISTEQRTQNEYGFSSAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHR
DFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEF

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Fusion Gene PPI Analysis for DUS2-UNC5C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneUNC5Cchr16:68072052chr4:96171818ENST00000453304316694_712198.0932.0DCC
TgeneUNC5Cchr16:68072052chr4:96171818ENST00000506749311694_712198.0598.0DCC


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDUS2chr16:68072052chr4:96171818ENST00000358896+216367_37142.0494.0tRNA
HgeneDUS2chr16:68072052chr4:96171818ENST00000358896+216420_42442.0494.0tRNA
HgeneDUS2chr16:68072052chr4:96171818ENST00000565263+317367_37142.0494.0tRNA
HgeneDUS2chr16:68072052chr4:96171818ENST00000565263+317420_42442.0494.0tRNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DUS2-UNC5C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DUS2-UNC5C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0002395Alzheimer's Disease2UNIPROT
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma1CTD_human