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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHCHD3-DDHD2 (FusionGDB2 ID:HG54927TG23259)

Fusion Gene Summary for CHCHD3-DDHD2

check button Fusion gene summary
Fusion gene informationFusion gene name: CHCHD3-DDHD2
Fusion gene ID: hg54927tg23259
HgeneTgene
Gene symbol

CHCHD3

DDHD2

Gene ID

54927

23259

Gene namecoiled-coil-helix-coiled-coil-helix domain containing 3DDHD domain containing 2
SynonymsMICOS19|MINOS3|Mic19|PPP1R22SAMWD1|SPG54|iPLA(1)gamma
Cytomap('CHCHD3')('DDHD2')

7q32.3-q33

8p11.23

Type of geneprotein-codingprotein-coding
DescriptionMICOS complex subunit MIC19coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrialmitochondrial contact site and cristae organizing system subunit 19mitochondrial inner membrane organizing system 3protein phosphatase 1, regulatophospholipase DDHD2PA-PLA1 likeSAM, WWE and DDHD domain-containing protein 1intracellular phospholipase A1gammasec23p-interacting protein p125-like phosphatidic acid-preferring phospholipase A1
Modification date2020032720200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262570, ENST00000448878, 
ENST00000542753, ENST00000476546, 
Fusion gene scores* DoF score23 X 25 X 10=575010 X 11 X 7=770
# samples 3112
** MAII scorelog2(31/5750*10)=-4.21322183544486
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/770*10)=-2.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHCHD3 [Title/Abstract] AND DDHD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHCHD3(132754902)-DDHD2(38103751), # samples:1
Anticipated loss of major functional domain due to fusion event.CHCHD3-DDHD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHCHD3-DDHD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHCHD3-DDHD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CHCHD3-DDHD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHCHD3

GO:0000122

negative regulation of transcription by RNA polymerase II

22567091


check buttonFusion gene breakpoints across CHCHD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DDHD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-A4Z0-01ACHCHD3chr7

132754902

-DDHD2chr8

38103751

+


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Fusion Gene ORF analysis for CHCHD3-DDHD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000262570ENST00000528888CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
5CDS-3UTRENST00000448878ENST00000528888CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
5CDS-3UTRENST00000542753ENST00000528888CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
5CDS-intronENST00000262570ENST00000517385CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
5CDS-intronENST00000262570ENST00000529845CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
5CDS-intronENST00000448878ENST00000517385CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
5CDS-intronENST00000448878ENST00000529845CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
5CDS-intronENST00000542753ENST00000517385CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
5CDS-intronENST00000542753ENST00000529845CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
In-frameENST00000262570ENST00000397166CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
In-frameENST00000262570ENST00000520272CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
In-frameENST00000448878ENST00000397166CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
In-frameENST00000448878ENST00000520272CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
In-frameENST00000542753ENST00000397166CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
In-frameENST00000542753ENST00000520272CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
intron-3CDSENST00000476546ENST00000397166CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
intron-3CDSENST00000476546ENST00000520272CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
intron-3UTRENST00000476546ENST00000528888CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
intron-intronENST00000476546ENST00000517385CHCHD3chr7

132754902

-DDHD2chr8

38103751

+
intron-intronENST00000476546ENST00000529845CHCHD3chr7

132754902

-DDHD2chr8

38103751

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262570CHCHD3chr7132754902-ENST00000397166DDHD2chr838103751+36533141451392415
ENST00000262570CHCHD3chr7132754902-ENST00000520272DDHD2chr838103751+35893141451392415
ENST00000448878CHCHD3chr7132754902-ENST00000397166DDHD2chr838103751+36252861171364415
ENST00000448878CHCHD3chr7132754902-ENST00000520272DDHD2chr838103751+35612861171364415
ENST00000542753CHCHD3chr7132754902-ENST00000397166DDHD2chr838103751+36112721031350415
ENST00000542753CHCHD3chr7132754902-ENST00000520272DDHD2chr838103751+35472721031350415

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262570ENST00000397166CHCHD3chr7132754902-DDHD2chr838103751+0.0002194350.9997806
ENST00000262570ENST00000520272CHCHD3chr7132754902-DDHD2chr838103751+0.0002220670.999778
ENST00000448878ENST00000397166CHCHD3chr7132754902-DDHD2chr838103751+0.0002164350.9997836
ENST00000448878ENST00000520272CHCHD3chr7132754902-DDHD2chr838103751+0.0002182950.99978167
ENST00000542753ENST00000397166CHCHD3chr7132754902-DDHD2chr838103751+0.0002145680.9997855
ENST00000542753ENST00000520272CHCHD3chr7132754902-DDHD2chr838103751+0.0002165810.99978346

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Fusion Genomic Features for CHCHD3-DDHD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CHCHD3chr7132754901-DDHD2chr838103750+2.99E-050.9999701
CHCHD3chr7132754901-DDHD2chr838103750+2.99E-050.9999701

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CHCHD3-DDHD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:132754902/chr8:38103751)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDDHD2chr7:132754902chr8:38103751ENST00000397166718385_4483521284.3333333333333DomainNote=SAM
TgeneDDHD2chr7:132754902chr8:38103751ENST00000397166718495_7003521284.3333333333333DomainDDHD
TgeneDDHD2chr7:132754902chr8:38103751ENST00000520272718385_4483521371.3333333333333DomainNote=SAM
TgeneDDHD2chr7:132754902chr8:38103751ENST00000520272718495_7003521371.3333333333333DomainDDHD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHCHD3chr7:132754902chr8:38103751ENST00000262570-28180_22256228.0DomainCHCH
HgeneCHCHD3chr7:132754902chr8:38103751ENST00000262570-28183_19356228.0MotifCx9C motif 1
HgeneCHCHD3chr7:132754902chr8:38103751ENST00000262570-28204_21456228.0MotifCx9C motif 2
TgeneDDHD2chr7:132754902chr8:38103751ENST0000039716671830_1123521284.3333333333333DomainWWE
TgeneDDHD2chr7:132754902chr8:38103751ENST0000052027271830_1123521371.3333333333333DomainWWE


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Fusion Gene Sequence for CHCHD3-DDHD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16236_16236_1_CHCHD3-DDHD2_CHCHD3_chr7_132754902_ENST00000262570_DDHD2_chr8_38103751_ENST00000397166_length(transcript)=3653nt_BP=314nt
CGCCTTCTCCTTGCTTCTGGGGGTCGTGGCCTTGCTCCCGCTGTGCGGGAAAAGAATCCAGGCCCTTCCACGCGCGTGTGGGTGCGGGGG
CCCCGAAGTGCTCGTGGTTCCCCGCTAGGTCTCCGCTGGGGCAGGAACCGGAATCATGGGTGGGACCACCAGCACCCGCCGGGTCACCTT
CGAGGCGGACGAGAATGAGAACATCACCGTGGTGAAGGGCATCCGGCTTTCGGAAAATGTGATTGATCGAATGAAGGAATCCTCTCCATC
TGGTTCGAAGTCTCAGCGGTATTCTGGTGCTTATGGTGCCTCAGGTTCGCTTATATTGTTTGATATCCTAACAAATCAGAAAGATTCTTT
GGGGGATATTGACAGTGAAAAGGATTCGCTAAATATTGTAATGGATCAAGGAGATACACCTACACTAGAGGAAGATTTGAAGAAACTTCA
GCTCTCTGAATTCTTTGATATCTTTGAGAAGGAGAAAGTAGATAAGGAAGCTCTGGCTTTATGTACAGACCGAGATCTTCAGGAAATAGG
AATTCCTTTAGGACCAAGAAAGAAGATATTAAACTATTTCAGCACCAGAAAAAACTCAATGGGTATTAAGAGACCAGCCCCGCAGCCTGC
TTCAGGGGCAAACATCCCCAAAGAATCTGAGTTCTGCAGTAGCAGTAATACTAGAAATGGTGACTATCTGGATGTTGGCATTGGGCAGGT
GTCTGTGAAATACCCCCGGCTCATCTATAAACCAGAGATATTCTTTGCCTTTGGATCTCCCATTGGAATGTTCCTTACTGTCCGAGGACT
AAAAAGAATTGATCCCAACTACAGATTTCCAACGTGCAAAGGTTTCTTCAATATTTATCACCCTTTTGATCCTGTGGCCTATAGGATTGA
ACCAATGGTGGTCCCAGGAGTGGAATTTGAGCCAATGCTGATCCCACATCATAAAGGCAGGAAGCGGATGCACTTAGAACTGAGAGAGGG
CTTGACCAGGATGAGTATGGACCTTAAGAACAACTTGCTAGGTTCGCTGCGGATGGCCTGGAAGTCTTTTACCAGAGCTCCATACCCTGC
CTTACAAGCTTCAGAAACACCAGAAGAAACTGAAGCAGAACCTGAATCAACTTCAGAGAAGCCTAGTGATGTTAACACAGAAGAGACCTC
TGTGGCAGTTAAAGAAGAAGTCCTGCCTATCAATGTGGGGATGCTGAATGGAGGCCAACGCATTGACTATGTGCTACAGGAGAAGCCTAT
TGAAAGTTTTAATGAGTATTTATTTGCTTTACAAAGCCATCTATGCTACTGGGAGTCTGAAGATACAGTATTGCTCGTCCTCAAAGAGAT
CTACCAAACCCAGGGTATCTTCCTTGATCAGCCTTTACAGTAAAAATGACCCATCTATGGCTGCTTAATACGGACATTGAGGGATCCTTC
CCCAGAAAATCCACCTGTTTGTTGCTGCAATTTTCCTCTCCTCAGCTGCGTCATTTCCTGCATGTTGCCTGCCACTTACTCACCACTGGG
GTCTTTGGAAGATAATCTTCCTCTTTGGAAATGAATGGAAAAGCAAAAGGCCCTATTACTTTTAACCACTGGCTTCATATAAACACTTGC
CATTTTTTTCTGCATAGCTGGGGGTGGTTTGTGTCTTTAATTCTTTGATGATAGTTTATAGTTGCCACACTTTATTGATTAGTACTTGAC
AGGGTGTAAAGCCTATTTTGGGTTTGATTTGTTTTGGGTGGGGTAGACATGTTTTTAAGGAACTTATTGCTTATCTTTAGAAAATGTTCT
AGTTTGGAAACAGATTCTTGAGATTCAGAAGGCATTTTGGAGTACACTTATCTCTTGTTTGTGTTGAACTGAAGGCTAAGTCTCAGTGGA
CATGGAAAAGACTTTTGGGTGATTTATTTTTGAACCTGCATTTCTTTCTTATGTGTAGTGTATGAAGAAAGACTAGAATGTAGCTTTAAA
AAAGTGTTGTTTACTCTCTTAGAACTGACAGACTTATTGCCAGAAATCACTGATGTTCATTGTTTTTGCAACTGTTTGAGCTGCTGTAAG
AGTCTAAAGTTGACAAGTTAGTTCATGTTAGGTGCATCTTTATAAAGCAAAGATGTTGTATATCCTAGGCCTCCCTTTTATATTTGATAG
AAGTTATTTGCTAATAGCTTCTATTCTTACGTTGAAAATAGTTGTAAAAGCTGATGAACCTGAAATTGTGTAGCCTCTACAGGCTGCTGA
GGTTCTAAATAAAACCTTTTAGTGGTGCCTTTATGGTGAAACAGAATTTGTCACCTGCCATTTCTACTTGAGCTAAGGTAGTATTGTGTA
TCCTCTTTCCTTCTTAGGTATCCATAATCCACAAAGCATATTTAAAAGGCTCTTGGCACGGGCAGCATTGGTTGAGCAGGTAGGTTTGGC
TAGGGGGAAATGTTTAACTTGTTCTGAAAGAAAAACTTATGTCTGTAGGGTCCAAGAAACAGCTATTCCAGAGTCAGTGTCAGCTGAGTC
TGGAACATATGAAGTGAGGTTTACTTCTAAGAACACAAGTGACTGCACACTAATTTTGTCAAGGCATCTTTTCACTACTTTGCTGTAGAT
TTTTCTTCTTCATTGGTCAGTTTGTCATTGTCTTTGTAGTTCTCTTTATGATAATCCTTTATACTTGCTCTCAGATTCCACAGGCCTCTG
TTTATAGAGTGGCAAAGGCAGGCGAGCTGTGGTTTATTGTTTATAAATTTTTTTATAAATGTTATGGTATTCAAAGCCACTGACATTTAA
TATTTACTGAAGCCATTCCTTAGACAGCAGTGGTCTTTATCCCTTTCTGGAAAGAAAAGGAAAATGAAGGGTAATTACTGTCACCATGGA
GATTGTAGAGGTAAGGTTGGGGTATAGGTCAGGCCTGGCCTTTCTTTGTCATCTGCTTATAGTCTAGTGCTAAGTATGCCACTAAGTTTC
AGATATATGGAATACTTTATTTTTTTAAAGGTATATAAACTCTGAGTTATTGAGAATTAAGTATTCACTGTATATTAAGGGGAAGCTTTT
GCCAAGTTGTGGTCTTCAAATTTATGTTTACTCTTCCTATTGGCAGAATAGGTGCTATTTAAGAGTAAACCAAAGGATAAGCAGAGGGAG
TCCCTATAACCAAAGATGGACAGCATAGCCCTGGATAGCCAGATAAACCACTCTTTGTATTAAGAAATGTTTCTTTCCTAGTGGTGAGGG
GTGGGTAACTGTGAAAGAGCTTTATATCTTGTCTATTCATGGTATTATAGCTGTATATTCCCAGGATGATAAGCTTGATTGAAATCCTGT
ATTTAGTCATATATTATTTGCGCTGCTTCATTTGTATCATGTGCAATCTCTAGACCAACCCTATTTTTAAACTCTGGTACAGCATCATTT
TGTACATATTCCCAGCTGCAGAACTAGTATCACTTATCTCAGCAAAAGAGATTGTTTGCATGGAAAGATTAATAGCACTGATTAGATTTC
TAATATTTTGCATTTTTGAAATGTTTGTTTTCTACGTGATTATATTTAAAACTTTAGTAAATACTAACATGAAACCATATTGACTAGTGG

>16236_16236_1_CHCHD3-DDHD2_CHCHD3_chr7_132754902_ENST00000262570_DDHD2_chr8_38103751_ENST00000397166_length(amino acids)=415AA_BP=56
MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASGSLILFDILTNQKDSLGDIDSEKDSLNIVMDQGD
TPTLEEDLKKLQLSEFFDIFEKEKVDKEALALCTDRDLQEIGIPLGPRKKILNYFSTRKNSMGIKRPAPQPASGANIPKESEFCSSSNTR
NGDYLDVGIGQVSVKYPRLIYKPEIFFAFGSPIGMFLTVRGLKRIDPNYRFPTCKGFFNIYHPFDPVAYRIEPMVVPGVEFEPMLIPHHK
GRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKSFTRAPYPALQASETPEETEAEPESTSEKPSDVNTEETSVAVKEEVLPINVGMLNGG

--------------------------------------------------------------
>16236_16236_2_CHCHD3-DDHD2_CHCHD3_chr7_132754902_ENST00000262570_DDHD2_chr8_38103751_ENST00000520272_length(transcript)=3589nt_BP=314nt
CGCCTTCTCCTTGCTTCTGGGGGTCGTGGCCTTGCTCCCGCTGTGCGGGAAAAGAATCCAGGCCCTTCCACGCGCGTGTGGGTGCGGGGG
CCCCGAAGTGCTCGTGGTTCCCCGCTAGGTCTCCGCTGGGGCAGGAACCGGAATCATGGGTGGGACCACCAGCACCCGCCGGGTCACCTT
CGAGGCGGACGAGAATGAGAACATCACCGTGGTGAAGGGCATCCGGCTTTCGGAAAATGTGATTGATCGAATGAAGGAATCCTCTCCATC
TGGTTCGAAGTCTCAGCGGTATTCTGGTGCTTATGGTGCCTCAGGTTCGCTTATATTGTTTGATATCCTAACAAATCAGAAAGATTCTTT
GGGGGATATTGACAGTGAAAAGGATTCGCTAAATATTGTAATGGATCAAGGAGATACACCTACACTAGAGGAAGATTTGAAGAAACTTCA
GCTCTCTGAATTCTTTGATATCTTTGAGAAGGAGAAAGTAGATAAGGAAGCTCTGGCTTTATGTACAGACCGAGATCTTCAGGAAATAGG
AATTCCTTTAGGACCAAGAAAGAAGATATTAAACTATTTCAGCACCAGAAAAAACTCAATGGGTATTAAGAGACCAGCCCCGCAGCCTGC
TTCAGGGGCAAACATCCCCAAAGAATCTGAGTTCTGCAGTAGCAGTAATACTAGAAATGGTGACTATCTGGATGTTGGCATTGGGCAGGT
GTCTGTGAAATACCCCCGGCTCATCTATAAACCAGAGATATTCTTTGCCTTTGGATCTCCCATTGGAATGTTCCTTACTGTCCGAGGACT
AAAAAGAATTGATCCCAACTACAGATTTCCAACGTGCAAAGGTTTCTTCAATATTTATCACCCTTTTGATCCTGTGGCCTATAGGATTGA
ACCAATGGTGGTCCCAGGAGTGGAATTTGAGCCAATGCTGATCCCACATCATAAAGGCAGGAAGCGGATGCACTTAGAACTGAGAGAGGG
CTTGACCAGGATGAGTATGGACCTTAAGAACAACTTGCTAGGTTCGCTGCGGATGGCCTGGAAGTCTTTTACCAGAGCTCCATACCCTGC
CTTACAAGCTTCAGAAACACCAGAAGAAACTGAAGCAGAACCTGAATCAACTTCAGAGAAGCCTAGTGATGTTAACACAGAAGAGACCTC
TGTGGCAGTTAAAGAAGAAGTCCTGCCTATCAATGTGGGGATGCTGAATGGAGGCCAACGCATTGACTATGTGCTACAGGAGAAGCCTAT
TGAAAGTTTTAATGAGTATTTATTTGCTTTACAAAGCCATCTATGCTACTGGGAGTCTGAAGATACAGTATTGCTCGTCCTCAAAGAGAT
CTACCAAACCCAGGGTATCTTCCTTGATCAGCCTTTACAGTAAAAATGACCCATCTATGGCTGCTTAATACGGACATTGAGGGATCCTTC
CCCAGAAAATCCACCTGTTTGTTGCTGCAATTTTCCTCTCCTCAGCTGCGTCATTTCCTGCATGTTGCCTGCCACTTACTCACCACTGGG
GTCTTTGGAAGATAATCTTCCTCTTTGGAAATGAATGGAAAAGCAAAAGGCCCTATTACTTTTAACCACTGGCTTCATATAAACACTTGC
CATTTTTTTCTGCATAGCTGGGGGTGGTTTGTGTCTTTAATTCTTTGATGATAGTTTATAGTTGCCACACTTTATTGATTAGTACTTGAC
AGGGTGTAAAGCCTATTTTGGGTTTGATTTGTTTTGGGTGGGGTAGACATGTTTTTAAGGAACTTATTGCTTATCTTTAGAAAATGTTCT
AGTTTGGAAACAGATTCTTGAGATTCAGAAGGCATTTTGGAGTACACTTATCTCTTGTTTGTGTTGAACTGAAGGCTAAGTCTCAGTGGA
CATGGAAAAGACTTTTGGGTGATTTATTTTTGAACCTGCATTTCTTTCTTATGTGTAGTGTATGAAGAAAGACTAGAATGTAGCTTTAAA
AAAGTGTTGTTTACTCTCTTAGAACTGACAGACTTATTGCCAGAAATCACTGATGTTCATTGTTTTTGCAACTGTTTGAGCTGCTGTAAG
AGTCTAAAGTTGACAAGTTAGTTCATGTTAGGTGCATCTTTATAAAGCAAAGATGTTGTATATCCTAGGCCTCCCTTTTATATTTGATAG
AAGTTATTTGCTAATAGCTTCTATTCTTACGTTGAAAATAGTTGTAAAAGCTGATGAACCTGAAATTGTGTAGCCTCTACAGGCTGCTGA
GGTTCTAAATAAAACCTTTTAGTGGTGCCTTTATGGTGAAACAGAATTTGTCACCTGCCATTTCTACTTGAGCTAAGGTAGTATTGTGTA
TCCTCTTTCCTTCTTAGGTATCCATAATCCACAAAGCATATTTAAAAGGCTCTTGGCACGGGCAGCATTGGTTGAGCAGGTAGGTTTGGC
TAGGGGGAAATGTTTAACTTGTTCTGAAAGAAAAACTTATGTCTGTAGGGTCCAAGAAACAGCTATTCCAGAGTCAGTGTCAGCTGAGTC
TGGAACATATGAAGTGAGGTTTACTTCTAAGAACACAAGTGACTGCACACTAATTTTGTCAAGGCATCTTTTCACTACTTTGCTGTAGAT
TTTTCTTCTTCATTGGTCAGTTTGTCATTGTCTTTGTAGTTCTCTTTATGATAATCCTTTATACTTGCTCTCAGATTCCACAGGCCTCTG
TTTATAGAGTGGCAAAGGCAGGCGAGCTGTGGTTTATTGTTTATAAATTTTTTTATAAATGTTATGGTATTCAAAGCCACTGACATTTAA
TATTTACTGAAGCCATTCCTTAGACAGCAGTGGTCTTTATCCCTTTCTGGAAAGAAAAGGAAAATGAAGGGTAATTACTGTCACCATGGA
GATTGTAGAGGTAAGGTTGGGGTATAGGTCAGGCCTGGCCTTTCTTTGTCATCTGCTTATAGTCTAGTGCTAAGTATGCCACTAAGTTTC
AGATATATGGAATACTTTATTTTTTTAAAGGTATATAAACTCTGAGTTATTGAGAATTAAGTATTCACTGTATATTAAGGGGAAGCTTTT
GCCAAGTTGTGGTCTTCAAATTTATGTTTACTCTTCCTATTGGCAGAATAGGTGCTATTTAAGAGTAAACCAAAGGATAAGCAGAGGGAG
TCCCTATAACCAAAGATGGACAGCATAGCCCTGGATAGCCAGATAAACCACTCTTTGTATTAAGAAATGTTTCTTTCCTAGTGGTGAGGG
GTGGGTAACTGTGAAAGAGCTTTATATCTTGTCTATTCATGGTATTATAGCTGTATATTCCCAGGATGATAAGCTTGATTGAAATCCTGT
ATTTAGTCATATATTATTTGCGCTGCTTCATTTGTATCATGTGCAATCTCTAGACCAACCCTATTTTTAAACTCTGGTACAGCATCATTT
TGTACATATTCCCAGCTGCAGAACTAGTATCACTTATCTCAGCAAAAGAGATTGTTTGCATGGAAAGATTAATAGCACTGATTAGATTTC

>16236_16236_2_CHCHD3-DDHD2_CHCHD3_chr7_132754902_ENST00000262570_DDHD2_chr8_38103751_ENST00000520272_length(amino acids)=415AA_BP=56
MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASGSLILFDILTNQKDSLGDIDSEKDSLNIVMDQGD
TPTLEEDLKKLQLSEFFDIFEKEKVDKEALALCTDRDLQEIGIPLGPRKKILNYFSTRKNSMGIKRPAPQPASGANIPKESEFCSSSNTR
NGDYLDVGIGQVSVKYPRLIYKPEIFFAFGSPIGMFLTVRGLKRIDPNYRFPTCKGFFNIYHPFDPVAYRIEPMVVPGVEFEPMLIPHHK
GRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKSFTRAPYPALQASETPEETEAEPESTSEKPSDVNTEETSVAVKEEVLPINVGMLNGG

--------------------------------------------------------------
>16236_16236_3_CHCHD3-DDHD2_CHCHD3_chr7_132754902_ENST00000448878_DDHD2_chr8_38103751_ENST00000397166_length(transcript)=3625nt_BP=286nt
GCCTTGCTCCCGCTGTGCGGGAAAAGAATCCAGGCCCTTCCACGCGCGTGTGGGTGCGGGGGCCCCGAAGTGCTCGTGGTTCCCCGCTAG
GTCTCCGCTGGGGCAGGAACCGGAATCATGGGTGGGACCACCAGCACCCGCCGGGTCACCTTCGAGGCGGACGAGAATGAGAACATCACC
GTGGTGAAGGGCATCCGGCTTTCGGAAAATGTGATTGATCGAATGAAGGAATCCTCTCCATCTGGTTCGAAGTCTCAGCGGTATTCTGGT
GCTTATGGTGCCTCAGGTTCGCTTATATTGTTTGATATCCTAACAAATCAGAAAGATTCTTTGGGGGATATTGACAGTGAAAAGGATTCG
CTAAATATTGTAATGGATCAAGGAGATACACCTACACTAGAGGAAGATTTGAAGAAACTTCAGCTCTCTGAATTCTTTGATATCTTTGAG
AAGGAGAAAGTAGATAAGGAAGCTCTGGCTTTATGTACAGACCGAGATCTTCAGGAAATAGGAATTCCTTTAGGACCAAGAAAGAAGATA
TTAAACTATTTCAGCACCAGAAAAAACTCAATGGGTATTAAGAGACCAGCCCCGCAGCCTGCTTCAGGGGCAAACATCCCCAAAGAATCT
GAGTTCTGCAGTAGCAGTAATACTAGAAATGGTGACTATCTGGATGTTGGCATTGGGCAGGTGTCTGTGAAATACCCCCGGCTCATCTAT
AAACCAGAGATATTCTTTGCCTTTGGATCTCCCATTGGAATGTTCCTTACTGTCCGAGGACTAAAAAGAATTGATCCCAACTACAGATTT
CCAACGTGCAAAGGTTTCTTCAATATTTATCACCCTTTTGATCCTGTGGCCTATAGGATTGAACCAATGGTGGTCCCAGGAGTGGAATTT
GAGCCAATGCTGATCCCACATCATAAAGGCAGGAAGCGGATGCACTTAGAACTGAGAGAGGGCTTGACCAGGATGAGTATGGACCTTAAG
AACAACTTGCTAGGTTCGCTGCGGATGGCCTGGAAGTCTTTTACCAGAGCTCCATACCCTGCCTTACAAGCTTCAGAAACACCAGAAGAA
ACTGAAGCAGAACCTGAATCAACTTCAGAGAAGCCTAGTGATGTTAACACAGAAGAGACCTCTGTGGCAGTTAAAGAAGAAGTCCTGCCT
ATCAATGTGGGGATGCTGAATGGAGGCCAACGCATTGACTATGTGCTACAGGAGAAGCCTATTGAAAGTTTTAATGAGTATTTATTTGCT
TTACAAAGCCATCTATGCTACTGGGAGTCTGAAGATACAGTATTGCTCGTCCTCAAAGAGATCTACCAAACCCAGGGTATCTTCCTTGAT
CAGCCTTTACAGTAAAAATGACCCATCTATGGCTGCTTAATACGGACATTGAGGGATCCTTCCCCAGAAAATCCACCTGTTTGTTGCTGC
AATTTTCCTCTCCTCAGCTGCGTCATTTCCTGCATGTTGCCTGCCACTTACTCACCACTGGGGTCTTTGGAAGATAATCTTCCTCTTTGG
AAATGAATGGAAAAGCAAAAGGCCCTATTACTTTTAACCACTGGCTTCATATAAACACTTGCCATTTTTTTCTGCATAGCTGGGGGTGGT
TTGTGTCTTTAATTCTTTGATGATAGTTTATAGTTGCCACACTTTATTGATTAGTACTTGACAGGGTGTAAAGCCTATTTTGGGTTTGAT
TTGTTTTGGGTGGGGTAGACATGTTTTTAAGGAACTTATTGCTTATCTTTAGAAAATGTTCTAGTTTGGAAACAGATTCTTGAGATTCAG
AAGGCATTTTGGAGTACACTTATCTCTTGTTTGTGTTGAACTGAAGGCTAAGTCTCAGTGGACATGGAAAAGACTTTTGGGTGATTTATT
TTTGAACCTGCATTTCTTTCTTATGTGTAGTGTATGAAGAAAGACTAGAATGTAGCTTTAAAAAAGTGTTGTTTACTCTCTTAGAACTGA
CAGACTTATTGCCAGAAATCACTGATGTTCATTGTTTTTGCAACTGTTTGAGCTGCTGTAAGAGTCTAAAGTTGACAAGTTAGTTCATGT
TAGGTGCATCTTTATAAAGCAAAGATGTTGTATATCCTAGGCCTCCCTTTTATATTTGATAGAAGTTATTTGCTAATAGCTTCTATTCTT
ACGTTGAAAATAGTTGTAAAAGCTGATGAACCTGAAATTGTGTAGCCTCTACAGGCTGCTGAGGTTCTAAATAAAACCTTTTAGTGGTGC
CTTTATGGTGAAACAGAATTTGTCACCTGCCATTTCTACTTGAGCTAAGGTAGTATTGTGTATCCTCTTTCCTTCTTAGGTATCCATAAT
CCACAAAGCATATTTAAAAGGCTCTTGGCACGGGCAGCATTGGTTGAGCAGGTAGGTTTGGCTAGGGGGAAATGTTTAACTTGTTCTGAA
AGAAAAACTTATGTCTGTAGGGTCCAAGAAACAGCTATTCCAGAGTCAGTGTCAGCTGAGTCTGGAACATATGAAGTGAGGTTTACTTCT
AAGAACACAAGTGACTGCACACTAATTTTGTCAAGGCATCTTTTCACTACTTTGCTGTAGATTTTTCTTCTTCATTGGTCAGTTTGTCAT
TGTCTTTGTAGTTCTCTTTATGATAATCCTTTATACTTGCTCTCAGATTCCACAGGCCTCTGTTTATAGAGTGGCAAAGGCAGGCGAGCT
GTGGTTTATTGTTTATAAATTTTTTTATAAATGTTATGGTATTCAAAGCCACTGACATTTAATATTTACTGAAGCCATTCCTTAGACAGC
AGTGGTCTTTATCCCTTTCTGGAAAGAAAAGGAAAATGAAGGGTAATTACTGTCACCATGGAGATTGTAGAGGTAAGGTTGGGGTATAGG
TCAGGCCTGGCCTTTCTTTGTCATCTGCTTATAGTCTAGTGCTAAGTATGCCACTAAGTTTCAGATATATGGAATACTTTATTTTTTTAA
AGGTATATAAACTCTGAGTTATTGAGAATTAAGTATTCACTGTATATTAAGGGGAAGCTTTTGCCAAGTTGTGGTCTTCAAATTTATGTT
TACTCTTCCTATTGGCAGAATAGGTGCTATTTAAGAGTAAACCAAAGGATAAGCAGAGGGAGTCCCTATAACCAAAGATGGACAGCATAG
CCCTGGATAGCCAGATAAACCACTCTTTGTATTAAGAAATGTTTCTTTCCTAGTGGTGAGGGGTGGGTAACTGTGAAAGAGCTTTATATC
TTGTCTATTCATGGTATTATAGCTGTATATTCCCAGGATGATAAGCTTGATTGAAATCCTGTATTTAGTCATATATTATTTGCGCTGCTT
CATTTGTATCATGTGCAATCTCTAGACCAACCCTATTTTTAAACTCTGGTACAGCATCATTTTGTACATATTCCCAGCTGCAGAACTAGT
ATCACTTATCTCAGCAAAAGAGATTGTTTGCATGGAAAGATTAATAGCACTGATTAGATTTCTAATATTTTGCATTTTTGAAATGTTTGT
TTTCTACGTGATTATATTTAAAACTTTAGTAAATACTAACATGAAACCATATTGACTAGTGGCCTACTTTTACCTGGACTCACCCGTCTC

>16236_16236_3_CHCHD3-DDHD2_CHCHD3_chr7_132754902_ENST00000448878_DDHD2_chr8_38103751_ENST00000397166_length(amino acids)=415AA_BP=56
MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASGSLILFDILTNQKDSLGDIDSEKDSLNIVMDQGD
TPTLEEDLKKLQLSEFFDIFEKEKVDKEALALCTDRDLQEIGIPLGPRKKILNYFSTRKNSMGIKRPAPQPASGANIPKESEFCSSSNTR
NGDYLDVGIGQVSVKYPRLIYKPEIFFAFGSPIGMFLTVRGLKRIDPNYRFPTCKGFFNIYHPFDPVAYRIEPMVVPGVEFEPMLIPHHK
GRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKSFTRAPYPALQASETPEETEAEPESTSEKPSDVNTEETSVAVKEEVLPINVGMLNGG

--------------------------------------------------------------
>16236_16236_4_CHCHD3-DDHD2_CHCHD3_chr7_132754902_ENST00000448878_DDHD2_chr8_38103751_ENST00000520272_length(transcript)=3561nt_BP=286nt
GCCTTGCTCCCGCTGTGCGGGAAAAGAATCCAGGCCCTTCCACGCGCGTGTGGGTGCGGGGGCCCCGAAGTGCTCGTGGTTCCCCGCTAG
GTCTCCGCTGGGGCAGGAACCGGAATCATGGGTGGGACCACCAGCACCCGCCGGGTCACCTTCGAGGCGGACGAGAATGAGAACATCACC
GTGGTGAAGGGCATCCGGCTTTCGGAAAATGTGATTGATCGAATGAAGGAATCCTCTCCATCTGGTTCGAAGTCTCAGCGGTATTCTGGT
GCTTATGGTGCCTCAGGTTCGCTTATATTGTTTGATATCCTAACAAATCAGAAAGATTCTTTGGGGGATATTGACAGTGAAAAGGATTCG
CTAAATATTGTAATGGATCAAGGAGATACACCTACACTAGAGGAAGATTTGAAGAAACTTCAGCTCTCTGAATTCTTTGATATCTTTGAG
AAGGAGAAAGTAGATAAGGAAGCTCTGGCTTTATGTACAGACCGAGATCTTCAGGAAATAGGAATTCCTTTAGGACCAAGAAAGAAGATA
TTAAACTATTTCAGCACCAGAAAAAACTCAATGGGTATTAAGAGACCAGCCCCGCAGCCTGCTTCAGGGGCAAACATCCCCAAAGAATCT
GAGTTCTGCAGTAGCAGTAATACTAGAAATGGTGACTATCTGGATGTTGGCATTGGGCAGGTGTCTGTGAAATACCCCCGGCTCATCTAT
AAACCAGAGATATTCTTTGCCTTTGGATCTCCCATTGGAATGTTCCTTACTGTCCGAGGACTAAAAAGAATTGATCCCAACTACAGATTT
CCAACGTGCAAAGGTTTCTTCAATATTTATCACCCTTTTGATCCTGTGGCCTATAGGATTGAACCAATGGTGGTCCCAGGAGTGGAATTT
GAGCCAATGCTGATCCCACATCATAAAGGCAGGAAGCGGATGCACTTAGAACTGAGAGAGGGCTTGACCAGGATGAGTATGGACCTTAAG
AACAACTTGCTAGGTTCGCTGCGGATGGCCTGGAAGTCTTTTACCAGAGCTCCATACCCTGCCTTACAAGCTTCAGAAACACCAGAAGAA
ACTGAAGCAGAACCTGAATCAACTTCAGAGAAGCCTAGTGATGTTAACACAGAAGAGACCTCTGTGGCAGTTAAAGAAGAAGTCCTGCCT
ATCAATGTGGGGATGCTGAATGGAGGCCAACGCATTGACTATGTGCTACAGGAGAAGCCTATTGAAAGTTTTAATGAGTATTTATTTGCT
TTACAAAGCCATCTATGCTACTGGGAGTCTGAAGATACAGTATTGCTCGTCCTCAAAGAGATCTACCAAACCCAGGGTATCTTCCTTGAT
CAGCCTTTACAGTAAAAATGACCCATCTATGGCTGCTTAATACGGACATTGAGGGATCCTTCCCCAGAAAATCCACCTGTTTGTTGCTGC
AATTTTCCTCTCCTCAGCTGCGTCATTTCCTGCATGTTGCCTGCCACTTACTCACCACTGGGGTCTTTGGAAGATAATCTTCCTCTTTGG
AAATGAATGGAAAAGCAAAAGGCCCTATTACTTTTAACCACTGGCTTCATATAAACACTTGCCATTTTTTTCTGCATAGCTGGGGGTGGT
TTGTGTCTTTAATTCTTTGATGATAGTTTATAGTTGCCACACTTTATTGATTAGTACTTGACAGGGTGTAAAGCCTATTTTGGGTTTGAT
TTGTTTTGGGTGGGGTAGACATGTTTTTAAGGAACTTATTGCTTATCTTTAGAAAATGTTCTAGTTTGGAAACAGATTCTTGAGATTCAG
AAGGCATTTTGGAGTACACTTATCTCTTGTTTGTGTTGAACTGAAGGCTAAGTCTCAGTGGACATGGAAAAGACTTTTGGGTGATTTATT
TTTGAACCTGCATTTCTTTCTTATGTGTAGTGTATGAAGAAAGACTAGAATGTAGCTTTAAAAAAGTGTTGTTTACTCTCTTAGAACTGA
CAGACTTATTGCCAGAAATCACTGATGTTCATTGTTTTTGCAACTGTTTGAGCTGCTGTAAGAGTCTAAAGTTGACAAGTTAGTTCATGT
TAGGTGCATCTTTATAAAGCAAAGATGTTGTATATCCTAGGCCTCCCTTTTATATTTGATAGAAGTTATTTGCTAATAGCTTCTATTCTT
ACGTTGAAAATAGTTGTAAAAGCTGATGAACCTGAAATTGTGTAGCCTCTACAGGCTGCTGAGGTTCTAAATAAAACCTTTTAGTGGTGC
CTTTATGGTGAAACAGAATTTGTCACCTGCCATTTCTACTTGAGCTAAGGTAGTATTGTGTATCCTCTTTCCTTCTTAGGTATCCATAAT
CCACAAAGCATATTTAAAAGGCTCTTGGCACGGGCAGCATTGGTTGAGCAGGTAGGTTTGGCTAGGGGGAAATGTTTAACTTGTTCTGAA
AGAAAAACTTATGTCTGTAGGGTCCAAGAAACAGCTATTCCAGAGTCAGTGTCAGCTGAGTCTGGAACATATGAAGTGAGGTTTACTTCT
AAGAACACAAGTGACTGCACACTAATTTTGTCAAGGCATCTTTTCACTACTTTGCTGTAGATTTTTCTTCTTCATTGGTCAGTTTGTCAT
TGTCTTTGTAGTTCTCTTTATGATAATCCTTTATACTTGCTCTCAGATTCCACAGGCCTCTGTTTATAGAGTGGCAAAGGCAGGCGAGCT
GTGGTTTATTGTTTATAAATTTTTTTATAAATGTTATGGTATTCAAAGCCACTGACATTTAATATTTACTGAAGCCATTCCTTAGACAGC
AGTGGTCTTTATCCCTTTCTGGAAAGAAAAGGAAAATGAAGGGTAATTACTGTCACCATGGAGATTGTAGAGGTAAGGTTGGGGTATAGG
TCAGGCCTGGCCTTTCTTTGTCATCTGCTTATAGTCTAGTGCTAAGTATGCCACTAAGTTTCAGATATATGGAATACTTTATTTTTTTAA
AGGTATATAAACTCTGAGTTATTGAGAATTAAGTATTCACTGTATATTAAGGGGAAGCTTTTGCCAAGTTGTGGTCTTCAAATTTATGTT
TACTCTTCCTATTGGCAGAATAGGTGCTATTTAAGAGTAAACCAAAGGATAAGCAGAGGGAGTCCCTATAACCAAAGATGGACAGCATAG
CCCTGGATAGCCAGATAAACCACTCTTTGTATTAAGAAATGTTTCTTTCCTAGTGGTGAGGGGTGGGTAACTGTGAAAGAGCTTTATATC
TTGTCTATTCATGGTATTATAGCTGTATATTCCCAGGATGATAAGCTTGATTGAAATCCTGTATTTAGTCATATATTATTTGCGCTGCTT
CATTTGTATCATGTGCAATCTCTAGACCAACCCTATTTTTAAACTCTGGTACAGCATCATTTTGTACATATTCCCAGCTGCAGAACTAGT
ATCACTTATCTCAGCAAAAGAGATTGTTTGCATGGAAAGATTAATAGCACTGATTAGATTTCTAATATTTTGCATTTTTGAAATGTTTGT

>16236_16236_4_CHCHD3-DDHD2_CHCHD3_chr7_132754902_ENST00000448878_DDHD2_chr8_38103751_ENST00000520272_length(amino acids)=415AA_BP=56
MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASGSLILFDILTNQKDSLGDIDSEKDSLNIVMDQGD
TPTLEEDLKKLQLSEFFDIFEKEKVDKEALALCTDRDLQEIGIPLGPRKKILNYFSTRKNSMGIKRPAPQPASGANIPKESEFCSSSNTR
NGDYLDVGIGQVSVKYPRLIYKPEIFFAFGSPIGMFLTVRGLKRIDPNYRFPTCKGFFNIYHPFDPVAYRIEPMVVPGVEFEPMLIPHHK
GRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKSFTRAPYPALQASETPEETEAEPESTSEKPSDVNTEETSVAVKEEVLPINVGMLNGG

--------------------------------------------------------------
>16236_16236_5_CHCHD3-DDHD2_CHCHD3_chr7_132754902_ENST00000542753_DDHD2_chr8_38103751_ENST00000397166_length(transcript)=3611nt_BP=272nt
GTGCGGGAAAAGAATCCAGGCCCTTCCACGCGCGTGTGGGTGCGGGGGCCCCGAAGTGCTCGTGGTTCCCCGCTAGGTCTCCGCTGGGGC
AGGAACCGGAATCATGGGTGGGACCACCAGCACCCGCCGGGTCACCTTCGAGGCGGACGAGAATGAGAACATCACCGTGGTGAAGGGCAT
CCGGCTTTCGGAAAATGTGATTGATCGAATGAAGGAATCCTCTCCATCTGGTTCGAAGTCTCAGCGGTATTCTGGTGCTTATGGTGCCTC
AGGTTCGCTTATATTGTTTGATATCCTAACAAATCAGAAAGATTCTTTGGGGGATATTGACAGTGAAAAGGATTCGCTAAATATTGTAAT
GGATCAAGGAGATACACCTACACTAGAGGAAGATTTGAAGAAACTTCAGCTCTCTGAATTCTTTGATATCTTTGAGAAGGAGAAAGTAGA
TAAGGAAGCTCTGGCTTTATGTACAGACCGAGATCTTCAGGAAATAGGAATTCCTTTAGGACCAAGAAAGAAGATATTAAACTATTTCAG
CACCAGAAAAAACTCAATGGGTATTAAGAGACCAGCCCCGCAGCCTGCTTCAGGGGCAAACATCCCCAAAGAATCTGAGTTCTGCAGTAG
CAGTAATACTAGAAATGGTGACTATCTGGATGTTGGCATTGGGCAGGTGTCTGTGAAATACCCCCGGCTCATCTATAAACCAGAGATATT
CTTTGCCTTTGGATCTCCCATTGGAATGTTCCTTACTGTCCGAGGACTAAAAAGAATTGATCCCAACTACAGATTTCCAACGTGCAAAGG
TTTCTTCAATATTTATCACCCTTTTGATCCTGTGGCCTATAGGATTGAACCAATGGTGGTCCCAGGAGTGGAATTTGAGCCAATGCTGAT
CCCACATCATAAAGGCAGGAAGCGGATGCACTTAGAACTGAGAGAGGGCTTGACCAGGATGAGTATGGACCTTAAGAACAACTTGCTAGG
TTCGCTGCGGATGGCCTGGAAGTCTTTTACCAGAGCTCCATACCCTGCCTTACAAGCTTCAGAAACACCAGAAGAAACTGAAGCAGAACC
TGAATCAACTTCAGAGAAGCCTAGTGATGTTAACACAGAAGAGACCTCTGTGGCAGTTAAAGAAGAAGTCCTGCCTATCAATGTGGGGAT
GCTGAATGGAGGCCAACGCATTGACTATGTGCTACAGGAGAAGCCTATTGAAAGTTTTAATGAGTATTTATTTGCTTTACAAAGCCATCT
ATGCTACTGGGAGTCTGAAGATACAGTATTGCTCGTCCTCAAAGAGATCTACCAAACCCAGGGTATCTTCCTTGATCAGCCTTTACAGTA
AAAATGACCCATCTATGGCTGCTTAATACGGACATTGAGGGATCCTTCCCCAGAAAATCCACCTGTTTGTTGCTGCAATTTTCCTCTCCT
CAGCTGCGTCATTTCCTGCATGTTGCCTGCCACTTACTCACCACTGGGGTCTTTGGAAGATAATCTTCCTCTTTGGAAATGAATGGAAAA
GCAAAAGGCCCTATTACTTTTAACCACTGGCTTCATATAAACACTTGCCATTTTTTTCTGCATAGCTGGGGGTGGTTTGTGTCTTTAATT
CTTTGATGATAGTTTATAGTTGCCACACTTTATTGATTAGTACTTGACAGGGTGTAAAGCCTATTTTGGGTTTGATTTGTTTTGGGTGGG
GTAGACATGTTTTTAAGGAACTTATTGCTTATCTTTAGAAAATGTTCTAGTTTGGAAACAGATTCTTGAGATTCAGAAGGCATTTTGGAG
TACACTTATCTCTTGTTTGTGTTGAACTGAAGGCTAAGTCTCAGTGGACATGGAAAAGACTTTTGGGTGATTTATTTTTGAACCTGCATT
TCTTTCTTATGTGTAGTGTATGAAGAAAGACTAGAATGTAGCTTTAAAAAAGTGTTGTTTACTCTCTTAGAACTGACAGACTTATTGCCA
GAAATCACTGATGTTCATTGTTTTTGCAACTGTTTGAGCTGCTGTAAGAGTCTAAAGTTGACAAGTTAGTTCATGTTAGGTGCATCTTTA
TAAAGCAAAGATGTTGTATATCCTAGGCCTCCCTTTTATATTTGATAGAAGTTATTTGCTAATAGCTTCTATTCTTACGTTGAAAATAGT
TGTAAAAGCTGATGAACCTGAAATTGTGTAGCCTCTACAGGCTGCTGAGGTTCTAAATAAAACCTTTTAGTGGTGCCTTTATGGTGAAAC
AGAATTTGTCACCTGCCATTTCTACTTGAGCTAAGGTAGTATTGTGTATCCTCTTTCCTTCTTAGGTATCCATAATCCACAAAGCATATT
TAAAAGGCTCTTGGCACGGGCAGCATTGGTTGAGCAGGTAGGTTTGGCTAGGGGGAAATGTTTAACTTGTTCTGAAAGAAAAACTTATGT
CTGTAGGGTCCAAGAAACAGCTATTCCAGAGTCAGTGTCAGCTGAGTCTGGAACATATGAAGTGAGGTTTACTTCTAAGAACACAAGTGA
CTGCACACTAATTTTGTCAAGGCATCTTTTCACTACTTTGCTGTAGATTTTTCTTCTTCATTGGTCAGTTTGTCATTGTCTTTGTAGTTC
TCTTTATGATAATCCTTTATACTTGCTCTCAGATTCCACAGGCCTCTGTTTATAGAGTGGCAAAGGCAGGCGAGCTGTGGTTTATTGTTT
ATAAATTTTTTTATAAATGTTATGGTATTCAAAGCCACTGACATTTAATATTTACTGAAGCCATTCCTTAGACAGCAGTGGTCTTTATCC
CTTTCTGGAAAGAAAAGGAAAATGAAGGGTAATTACTGTCACCATGGAGATTGTAGAGGTAAGGTTGGGGTATAGGTCAGGCCTGGCCTT
TCTTTGTCATCTGCTTATAGTCTAGTGCTAAGTATGCCACTAAGTTTCAGATATATGGAATACTTTATTTTTTTAAAGGTATATAAACTC
TGAGTTATTGAGAATTAAGTATTCACTGTATATTAAGGGGAAGCTTTTGCCAAGTTGTGGTCTTCAAATTTATGTTTACTCTTCCTATTG
GCAGAATAGGTGCTATTTAAGAGTAAACCAAAGGATAAGCAGAGGGAGTCCCTATAACCAAAGATGGACAGCATAGCCCTGGATAGCCAG
ATAAACCACTCTTTGTATTAAGAAATGTTTCTTTCCTAGTGGTGAGGGGTGGGTAACTGTGAAAGAGCTTTATATCTTGTCTATTCATGG
TATTATAGCTGTATATTCCCAGGATGATAAGCTTGATTGAAATCCTGTATTTAGTCATATATTATTTGCGCTGCTTCATTTGTATCATGT
GCAATCTCTAGACCAACCCTATTTTTAAACTCTGGTACAGCATCATTTTGTACATATTCCCAGCTGCAGAACTAGTATCACTTATCTCAG
CAAAAGAGATTGTTTGCATGGAAAGATTAATAGCACTGATTAGATTTCTAATATTTTGCATTTTTGAAATGTTTGTTTTCTACGTGATTA
TATTTAAAACTTTAGTAAATACTAACATGAAACCATATTGACTAGTGGCCTACTTTTACCTGGACTCACCCGTCTCAAAGTCAAGAAAAT

>16236_16236_5_CHCHD3-DDHD2_CHCHD3_chr7_132754902_ENST00000542753_DDHD2_chr8_38103751_ENST00000397166_length(amino acids)=415AA_BP=56
MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASGSLILFDILTNQKDSLGDIDSEKDSLNIVMDQGD
TPTLEEDLKKLQLSEFFDIFEKEKVDKEALALCTDRDLQEIGIPLGPRKKILNYFSTRKNSMGIKRPAPQPASGANIPKESEFCSSSNTR
NGDYLDVGIGQVSVKYPRLIYKPEIFFAFGSPIGMFLTVRGLKRIDPNYRFPTCKGFFNIYHPFDPVAYRIEPMVVPGVEFEPMLIPHHK
GRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKSFTRAPYPALQASETPEETEAEPESTSEKPSDVNTEETSVAVKEEVLPINVGMLNGG

--------------------------------------------------------------
>16236_16236_6_CHCHD3-DDHD2_CHCHD3_chr7_132754902_ENST00000542753_DDHD2_chr8_38103751_ENST00000520272_length(transcript)=3547nt_BP=272nt
GTGCGGGAAAAGAATCCAGGCCCTTCCACGCGCGTGTGGGTGCGGGGGCCCCGAAGTGCTCGTGGTTCCCCGCTAGGTCTCCGCTGGGGC
AGGAACCGGAATCATGGGTGGGACCACCAGCACCCGCCGGGTCACCTTCGAGGCGGACGAGAATGAGAACATCACCGTGGTGAAGGGCAT
CCGGCTTTCGGAAAATGTGATTGATCGAATGAAGGAATCCTCTCCATCTGGTTCGAAGTCTCAGCGGTATTCTGGTGCTTATGGTGCCTC
AGGTTCGCTTATATTGTTTGATATCCTAACAAATCAGAAAGATTCTTTGGGGGATATTGACAGTGAAAAGGATTCGCTAAATATTGTAAT
GGATCAAGGAGATACACCTACACTAGAGGAAGATTTGAAGAAACTTCAGCTCTCTGAATTCTTTGATATCTTTGAGAAGGAGAAAGTAGA
TAAGGAAGCTCTGGCTTTATGTACAGACCGAGATCTTCAGGAAATAGGAATTCCTTTAGGACCAAGAAAGAAGATATTAAACTATTTCAG
CACCAGAAAAAACTCAATGGGTATTAAGAGACCAGCCCCGCAGCCTGCTTCAGGGGCAAACATCCCCAAAGAATCTGAGTTCTGCAGTAG
CAGTAATACTAGAAATGGTGACTATCTGGATGTTGGCATTGGGCAGGTGTCTGTGAAATACCCCCGGCTCATCTATAAACCAGAGATATT
CTTTGCCTTTGGATCTCCCATTGGAATGTTCCTTACTGTCCGAGGACTAAAAAGAATTGATCCCAACTACAGATTTCCAACGTGCAAAGG
TTTCTTCAATATTTATCACCCTTTTGATCCTGTGGCCTATAGGATTGAACCAATGGTGGTCCCAGGAGTGGAATTTGAGCCAATGCTGAT
CCCACATCATAAAGGCAGGAAGCGGATGCACTTAGAACTGAGAGAGGGCTTGACCAGGATGAGTATGGACCTTAAGAACAACTTGCTAGG
TTCGCTGCGGATGGCCTGGAAGTCTTTTACCAGAGCTCCATACCCTGCCTTACAAGCTTCAGAAACACCAGAAGAAACTGAAGCAGAACC
TGAATCAACTTCAGAGAAGCCTAGTGATGTTAACACAGAAGAGACCTCTGTGGCAGTTAAAGAAGAAGTCCTGCCTATCAATGTGGGGAT
GCTGAATGGAGGCCAACGCATTGACTATGTGCTACAGGAGAAGCCTATTGAAAGTTTTAATGAGTATTTATTTGCTTTACAAAGCCATCT
ATGCTACTGGGAGTCTGAAGATACAGTATTGCTCGTCCTCAAAGAGATCTACCAAACCCAGGGTATCTTCCTTGATCAGCCTTTACAGTA
AAAATGACCCATCTATGGCTGCTTAATACGGACATTGAGGGATCCTTCCCCAGAAAATCCACCTGTTTGTTGCTGCAATTTTCCTCTCCT
CAGCTGCGTCATTTCCTGCATGTTGCCTGCCACTTACTCACCACTGGGGTCTTTGGAAGATAATCTTCCTCTTTGGAAATGAATGGAAAA
GCAAAAGGCCCTATTACTTTTAACCACTGGCTTCATATAAACACTTGCCATTTTTTTCTGCATAGCTGGGGGTGGTTTGTGTCTTTAATT
CTTTGATGATAGTTTATAGTTGCCACACTTTATTGATTAGTACTTGACAGGGTGTAAAGCCTATTTTGGGTTTGATTTGTTTTGGGTGGG
GTAGACATGTTTTTAAGGAACTTATTGCTTATCTTTAGAAAATGTTCTAGTTTGGAAACAGATTCTTGAGATTCAGAAGGCATTTTGGAG
TACACTTATCTCTTGTTTGTGTTGAACTGAAGGCTAAGTCTCAGTGGACATGGAAAAGACTTTTGGGTGATTTATTTTTGAACCTGCATT
TCTTTCTTATGTGTAGTGTATGAAGAAAGACTAGAATGTAGCTTTAAAAAAGTGTTGTTTACTCTCTTAGAACTGACAGACTTATTGCCA
GAAATCACTGATGTTCATTGTTTTTGCAACTGTTTGAGCTGCTGTAAGAGTCTAAAGTTGACAAGTTAGTTCATGTTAGGTGCATCTTTA
TAAAGCAAAGATGTTGTATATCCTAGGCCTCCCTTTTATATTTGATAGAAGTTATTTGCTAATAGCTTCTATTCTTACGTTGAAAATAGT
TGTAAAAGCTGATGAACCTGAAATTGTGTAGCCTCTACAGGCTGCTGAGGTTCTAAATAAAACCTTTTAGTGGTGCCTTTATGGTGAAAC
AGAATTTGTCACCTGCCATTTCTACTTGAGCTAAGGTAGTATTGTGTATCCTCTTTCCTTCTTAGGTATCCATAATCCACAAAGCATATT
TAAAAGGCTCTTGGCACGGGCAGCATTGGTTGAGCAGGTAGGTTTGGCTAGGGGGAAATGTTTAACTTGTTCTGAAAGAAAAACTTATGT
CTGTAGGGTCCAAGAAACAGCTATTCCAGAGTCAGTGTCAGCTGAGTCTGGAACATATGAAGTGAGGTTTACTTCTAAGAACACAAGTGA
CTGCACACTAATTTTGTCAAGGCATCTTTTCACTACTTTGCTGTAGATTTTTCTTCTTCATTGGTCAGTTTGTCATTGTCTTTGTAGTTC
TCTTTATGATAATCCTTTATACTTGCTCTCAGATTCCACAGGCCTCTGTTTATAGAGTGGCAAAGGCAGGCGAGCTGTGGTTTATTGTTT
ATAAATTTTTTTATAAATGTTATGGTATTCAAAGCCACTGACATTTAATATTTACTGAAGCCATTCCTTAGACAGCAGTGGTCTTTATCC
CTTTCTGGAAAGAAAAGGAAAATGAAGGGTAATTACTGTCACCATGGAGATTGTAGAGGTAAGGTTGGGGTATAGGTCAGGCCTGGCCTT
TCTTTGTCATCTGCTTATAGTCTAGTGCTAAGTATGCCACTAAGTTTCAGATATATGGAATACTTTATTTTTTTAAAGGTATATAAACTC
TGAGTTATTGAGAATTAAGTATTCACTGTATATTAAGGGGAAGCTTTTGCCAAGTTGTGGTCTTCAAATTTATGTTTACTCTTCCTATTG
GCAGAATAGGTGCTATTTAAGAGTAAACCAAAGGATAAGCAGAGGGAGTCCCTATAACCAAAGATGGACAGCATAGCCCTGGATAGCCAG
ATAAACCACTCTTTGTATTAAGAAATGTTTCTTTCCTAGTGGTGAGGGGTGGGTAACTGTGAAAGAGCTTTATATCTTGTCTATTCATGG
TATTATAGCTGTATATTCCCAGGATGATAAGCTTGATTGAAATCCTGTATTTAGTCATATATTATTTGCGCTGCTTCATTTGTATCATGT
GCAATCTCTAGACCAACCCTATTTTTAAACTCTGGTACAGCATCATTTTGTACATATTCCCAGCTGCAGAACTAGTATCACTTATCTCAG
CAAAAGAGATTGTTTGCATGGAAAGATTAATAGCACTGATTAGATTTCTAATATTTTGCATTTTTGAAATGTTTGTTTTCTACGTGATTA

>16236_16236_6_CHCHD3-DDHD2_CHCHD3_chr7_132754902_ENST00000542753_DDHD2_chr8_38103751_ENST00000520272_length(amino acids)=415AA_BP=56
MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASGSLILFDILTNQKDSLGDIDSEKDSLNIVMDQGD
TPTLEEDLKKLQLSEFFDIFEKEKVDKEALALCTDRDLQEIGIPLGPRKKILNYFSTRKNSMGIKRPAPQPASGANIPKESEFCSSSNTR
NGDYLDVGIGQVSVKYPRLIYKPEIFFAFGSPIGMFLTVRGLKRIDPNYRFPTCKGFFNIYHPFDPVAYRIEPMVVPGVEFEPMLIPHHK
GRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKSFTRAPYPALQASETPEETEAEPESTSEKPSDVNTEETSVAVKEEVLPINVGMLNGG

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Fusion Gene PPI Analysis for CHCHD3-DDHD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHCHD3-DDHD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHCHD3-DDHD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHCHD3C0013146Drug abuse1CTD_human
HgeneCHCHD3C0013170Drug habituation1CTD_human
HgeneCHCHD3C0013222Drug Use Disorders1CTD_human
HgeneCHCHD3C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneCHCHD3C0038580Substance Dependence1CTD_human
HgeneCHCHD3C0038586Substance Use Disorders1CTD_human
HgeneCHCHD3C0236969Substance-Related Disorders1CTD_human
HgeneCHCHD3C0740858Substance abuse problem1CTD_human
HgeneCHCHD3C1510472Drug Dependence1CTD_human
HgeneCHCHD3C4316881Prescription Drug Abuse1CTD_human
TgeneC3539495SPASTIC PARAPLEGIA 54, AUTOSOMAL RECESSIVE3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT