Fusion Gene Studies
in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCDC109B-LMO7 (FusionGDB2 ID:HG55013TG4008)

Fusion Gene Summary for CCDC109B-LMO7

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC109B-LMO7
Fusion gene ID: hg55013tg4008
HgeneTgene
Gene symbol

CCDC109B

LMO7

Gene ID

55013

4008

Gene namemitochondrial calcium uniporter dominant negative subunit betaLIM domain 7
SynonymsCCDC109BFBX20|FBXO20|LMO7b|LOMP
Cytomap('CCDC109B')('LMO7')

4q25

13q22.2

Type of geneprotein-codingprotein-coding
Descriptioncalcium uniporter regulatory subunit MCUb, mitochondrialcoiled-coil domain containing 109Bcoiled-coil domain-containing protein 109Bmitochondrial calcium uniporter dominant negative beta subunitmitochondrial calcium uniporter regulatory subunit MCUbLIM domain only protein 7F-box only protein 20F-box protein Fbx20LIM domain only 7 proteinLMO-7zinc-finger domain-containing protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000515114, ENST00000394650, 
Fusion gene scores* DoF score5 X 2 X 3=307 X 8 X 4=224
# samples 58
** MAII scorelog2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC109B [Title/Abstract] AND LMO7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCDC109B(110481592)-LMO7(76335068), # samples:1
Anticipated loss of major functional domain due to fusion event.CCDC109B-LMO7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCDC109B-LMO7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCDC109B-LMO7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CCDC109B-LMO7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLMO7

GO:0045944

positive regulation of transcription by RNA polymerase II

17067998


check buttonFusion gene breakpoints across CCDC109B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LMO7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A44T-01ACCDC109Bchr4

110481592

+LMO7chr13

76335068

+


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Fusion Gene ORF analysis for CCDC109B-LMO7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000515114ENST00000341547CCDC109Bchr4

110481592

+LMO7chr13

76335068

+
3UTR-3CDSENST00000515114ENST00000357063CCDC109Bchr4

110481592

+LMO7chr13

76335068

+
3UTR-3CDSENST00000515114ENST00000377534CCDC109Bchr4

110481592

+LMO7chr13

76335068

+
3UTR-5UTRENST00000515114ENST00000321797CCDC109Bchr4

110481592

+LMO7chr13

76335068

+
3UTR-5UTRENST00000515114ENST00000465261CCDC109Bchr4

110481592

+LMO7chr13

76335068

+
3UTR-5UTRENST00000515114ENST00000526202CCDC109Bchr4

110481592

+LMO7chr13

76335068

+
3UTR-intronENST00000515114ENST00000605961CCDC109Bchr4

110481592

+LMO7chr13

76335068

+
5CDS-5UTRENST00000394650ENST00000321797CCDC109Bchr4

110481592

+LMO7chr13

76335068

+
5CDS-5UTRENST00000394650ENST00000465261CCDC109Bchr4

110481592

+LMO7chr13

76335068

+
5CDS-5UTRENST00000394650ENST00000526202CCDC109Bchr4

110481592

+LMO7chr13

76335068

+
5CDS-intronENST00000394650ENST00000605961CCDC109Bchr4

110481592

+LMO7chr13

76335068

+
In-frameENST00000394650ENST00000341547CCDC109Bchr4

110481592

+LMO7chr13

76335068

+
In-frameENST00000394650ENST00000357063CCDC109Bchr4

110481592

+LMO7chr13

76335068

+
In-frameENST00000394650ENST00000377534CCDC109Bchr4

110481592

+LMO7chr13

76335068

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394650CCDC109Bchr4110481592+ENST00000341547LMO7chr1376335068+583923210339151270
ENST00000394650CCDC109Bchr4110481592+ENST00000357063LMO7chr1376335068+673423210348781591
ENST00000394650CCDC109Bchr4110481592+ENST00000377534LMO7chr1376335068+663123210347101535

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394650ENST00000341547CCDC109Bchr4110481592+LMO7chr1376335068+0.000129760.9998702
ENST00000394650ENST00000357063CCDC109Bchr4110481592+LMO7chr1376335068+0.0001071230.99989283
ENST00000394650ENST00000377534CCDC109Bchr4110481592+LMO7chr1376335068+0.0002046290.9997954

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Fusion Genomic Features for CCDC109B-LMO7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CCDC109Bchr4110481592+LMO7chr1376335067+0.0024419040.9975581
CCDC109Bchr4110481592+LMO7chr1376335067+0.0024419040.9975581

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CCDC109B-LMO7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:110481592/chr13:76335068)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLMO7chr4:110481592chr13:76335068ENST000003415473301042_11281221350.0DomainPDZ
TgeneLMO7chr4:110481592chr13:76335068ENST000003415473301612_16781221350.0DomainLIM zinc-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC109Bchr4:110481592chr13:76335068ENST00000394650+18179_21033337.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC109Bchr4:110481592chr13:76335068ENST00000394650+18297_32333337.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC109Bchr4:110481592chr13:76335068ENST00000394650+18220_24033337.0TransmembraneHelical
HgeneCCDC109Bchr4:110481592chr13:76335068ENST00000394650+18250_27033337.0TransmembraneHelical
TgeneLMO7chr4:110481592chr13:76335068ENST0000034154733064_1811221350.0DomainCalponin-homology (CH)


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Fusion Gene Sequence for CCDC109B-LMO7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13574_13574_1_CCDC109B-LMO7_CCDC109B_chr4_110481592_ENST00000394650_LMO7_chr13_76335068_ENST00000341547_length(transcript)=5839nt_BP=232nt
AGCCGCGGCGCGCTGAGCGAGCAGGCGGGGCGGGAGCGCCCACAGCTCGGAGCCACCAGGCGCTGACGAGGAGCCCGGCTGAGGGAGGAT
GCGCCGCTGACGCCTGCGGGAGCCGCGCGCCTGGGGCGGGAGGATGCTCCAGAGGGGCCTCTGGCCGTGGCGCACGCGGCTGCTGCCGAC
CCCTGGCACCTGGCGCCCAGCGCGCCCGTGGCCGCTGCCGCCTCCGCCCCAGGATAATATAAACGTTTTCTTGAAAGCTTGTGAACAGAT
TGGATTGAAAGAAGCCCAGCTTTTCCATCCTGGAGATCTACAGGATTTATCAAATCGAGTCACTGTCAAGCAAGAAGAGACTGACAGGAG
AGTGAAAAATGTTTTGATAACATTGTACTGGCTGGGAAGAAAAGCACAAAGCAACCCGTACTATAATGGTCCCCATCTTAATTTGAAAGC
GTTTGAGAATCTTTTAGGACAAGCACTGACGAAGGCACTCGAAGACTCCAGCTTCCTGAAAAGAAGTGGCAGGGACAGTGGCTACGGTGA
CATCTGGTGTCCTGAACGTGGAGAATTTCTTGCTCCTCCAAGGCACCATAAGAGAGAAGATTCCTTTGAAAGCTTGGACTCTTTGGGCTC
GAGGTCATTGACAAGCTGCTCCTCTGATATCACGTTGAGAGGGGGGCGTGAAGGTTTTGAAAGTGACACAGATTCGGAATTTACATTTAA
GATGCAGGATTATAATAAAGATGATATGTCGTATCGAAGGATTTCGGCTGTTGAGCCAAAGACTGCGTTACCCTTCAATCGTTTTTTACC
CAACAAAAGTAGACAGCCATCCTATGTACCAGCACCTCTGAGAAAGAAAAAGCCAGACAAACATGAGGATAACAGAAGAAGTTGGGCAAG
CCCGGTTTATACAGAAGCAGATGGAACATTTTCAAGACTCTTTCAAAAGATTTATGGTGAGAATGGGAGTAAGTCCATGAGTGATGTCAG
CGCAGAAGATGTTCAAAACTTGCGTCAGCTGCGTTACGAGGAGATGCAGAAAATAAAATCACAATTAAAAGAACAAGATCAGAAATGGCA
GGATGACCTTGCAAAATGGAAAGATCGTCGAAAAAGTTACACTTCAGATCTGCAGAAGAAAAAAGAAGAGAGAGAAGAAATTGAAAAGCA
GGCACTTGAGAAGTCTAAGAGAAGCTCTAAGACGTTTAAGGAAATGCTGCAGGACAGGGAATCCCAAAATCAAAAGTCTACAGTTCCGTC
AAGAAGGAGAATGTATTCTTTTGATGATGTGCTGGAGGAAGGAAAGCGACCCCCTACAATGACTGTGTCAGAAGCAAGTTACCAGAGTGA
GAGAGTAGAAGAGAAGGGAGCAACTTATCCTTCAGAAATTCCCAAAGAAGATTCTACCACTTTTGCAAAAAGAGAGGACCGTGTAACAAC
TGAAATTCAGCTTCCTTCTCAAAGTCCTGTGGAAGAACAAAGCCCAGCCTCTTTGTCTTCTCTGCGTTCACGGAGCACACAAATGGAATC
AACTCGTGTTTCAGCTTCTCTCCCCAGAAGTTACCGGAAAACTGATACAGTCAGGTTAACATCTGTGGTCACACCAAGACCCTTTGGCTC
TCAGACAAGGGGAATCTCATCACTCCCCAGATCTTACACGATGGATGATGCTTGGAAGTATAATGGAGATGTTGAAGACATTAAGAGAAC
TCCAAACAATGTGGTCAGCACCCCTGCACCAAGCCCGGACGCAAGCCAACTGGCTTCAAGCTTATCTAGCCAGAAAGAGGTAGCAGCAAC
AGAAGAAGATGTGACAAGGCTGCCCTCTCCTACATCCCCCTTCTCATCTCTTTCCCAAGACCAGGCTGCCACTTCTAAAGCCACATTGTC
TTCCACATCTGGTCTTGATTTAATGTCTGAATCTGGAGAAGGGGAAATCTCCCCACAAAGAGAAGTCTCAAGATCCCAGGATCAGTTCAG
TGATATGAGAATCAGCATAAACCAGACGCCTGGGAAGAGTCTTGACTTTGGGTTTACAATAAAATGGGATATTCCTGGGATCTTCGTAGC
ATCAGTTGAAGCAGGTAGCCCAGCAGAATTTTCTCAGCTACAAGTAGATGATGAAATTATTGCTATTAACAACACCAAGTTTTCATATAA
CGATTCAAAAGAGTGGGAGGAAGCCATGGCTAAGGCTCAAGAAACTGGACACCTAGTGATGGATGTGAGGCGCTATGGAAAGGCTGGTTC
ACCTGAAACAAAGTGGATTGATGCAACTTCTGGAATTTACAACTCAGAAAAATCTTCAAATCTATCTGTAACAACTGATTTCTCCGAAAG
CCTTCAGAGTTCTAATATTGAATCCAAAGAAATCAATGGAATTCATGATGAAAGCAATGCTTTTGAATCAAAAGCATCTGAATCCATTTC
TTTGAAAAACTTAAAAAGGCGATCACAATTTTTTGAACAAGGAAGCTCTGATTCGGTGGTTCCTGATCTTCCAGTTCCAACCATCAGTGC
CCCGAGTCGCTGGGTGTGGGATCAAGAGGAGGAGCGGAAGCGGCAGGAGAGGTGGCAGAAGGAGCAGGACCGCCTACTGCAGGAAAAATA
TCAACGTGAGCAGGAGAAACTGAGGGAAGAGTGGCAAAGGGCCAAACAGGAGGCAGAGAGAGAGAATTCCAAGTACTTGGATGAGGAACT
GATGGTCCTAAGCTCAAACAGCATGTCTCTGACCACACGGGAGCCCTCTCTTGCCACCTGGGAAGCTACCTGGAGTGAAGGGTCCAAGTC
TTCAGACAGAGAAGGAACCCGAGCAGGAGAAGAGGAGAGGAGACAGCCACAAGAGGAAGTTGTTCATGAGGACCAAGGAAAGAAGCCGCA
GGATCAGCTTGTTATTGAGAGAGAGAGGAAATGGGAGCAACAGCTTCAGGAAGAGCAAGAGCAAAAGCGGCTTCAGGCTGAGGCTGAGGA
GCAGAAGCGTCCTGCGGAGGAGCAGAAGCGCCAGGCAGAGATAGAGCGGGAAACATCAGTCAGAATATACCAGTACAGGAGGCCTGTTGA
TTCCTATGATATACCAAAGACAGAAGAAGCATCTTCAGGTTTTCTTCCTGGTGACAGGAATAAATCCAGATCTACTACTGAACTGGATGA
TTACTCCACAAATAAAAATGGAAACAATAAATATTTAGACCAAATTGGGAACATGACCTCTTCACAGAGGAGATCCAAGAAAGAACAAGT
ACCATCAGGAGCAGAATTGGAGAGGCAACAAATCCTTCAGGAAATGAGGAAGAGAACACCCCTTCACAATGACAACAGCTGGATCCGACA
GCGCAGTGCCAGTGTCAACAAAGAGCCTGTTAGTCTTCCTGGGATCATGAGAAGAGGCGAATCTTTAGATAACCTGGACTCCCCCCGATC
CAATTCTTGGAGACAGCCTCCTTGGCTCAATCAGCCCACAGGATTCTATGCTTCTTCCTCTGTGCAAGACTTTAGTCGCCCACCACCTCA
GCTGGTGTCCACATCAAACCGTGCCTACATGCGGAACCCCTCCTCCAGCGTGCCCCCACCTTCAGCTGGCTCCGTGAAGACCTCCACCAC
AGGTGTGGCCACCACACAGTCCCCCACCCCGAGAAGCCATTCCCCTTCAGCTTCACAGTCAGGCTCTCAGCTGCGTAACAGGTCAGTCAG
TGGGAAGCGCATATGCTCCTACTGCAATAACATTCTGGGCAAAGGAGCCGCCATGATCATCGAGTCCCTGGGTCTTTGTTATCATTTGCA
TTGTTTTAAGTGTGTTGCCTGTGAGTGTGACCTCGGAGGCTCTTCCTCAGGAGCTGAAGTCAGGATCAGAAACCACCAACTGTACTGCAA
CGACTGCTATCTCAGATTCAAATCTGGACGGCCAACCGCCATGTGATGTAAGCCTCCATACGAAAGCACTGTTGCAGATAGAAGAAGAGG
TGGTTGCTGCTCATGTAGATCTATAAATATGTGTTGTATGTCTTTTTTGCTTTTTTTTTAAAAAAAAGAATAACTTTTTTTGCCTCTTTA
GATTACATAGAAGCATTGTAGTCTTGGTAGAACCAGTATTTTTGTTGTTTATTTATAAGGTAATTGTGTGTGGGGAAAAGTGCAGTATTT
ACCTGTTGAATTCAGCATCTTGAGAGCACAAGGGAAAAAATAAGAACCTACGAATATTTTTGAGGCAGATAATGATCTAGTTTGACTTTC
TAGTTAGTGGTGTTTTGAAGAGGGTATTTTATTGTTTTTTAAAAAAAGGTTCTTAAACATTATTTGAAATAGTTAATATAAATACATAAT
TGCATTTGCTCTGTTTATTGTAATGTATTCTAAATTAATGCAGAACCATATGGAAAATTTCATTAAAATCTATCCCCAAATGTGCTTTCT
GTATCCTTCCTTCTACCTATTATTCTGATTTTTAAAAATGCAGTTAATGTACCATTTATTTGCTTGATGAAGGGAGCTCTATTTTCTTTA
CCAGAAATGTTGCTAAGTAATTCCCAATAGAAAGCTGCTTATTTTCATTAATGAAAAATAACCATGGTTTGTATACTAGAAGTCTTCTTC
AGAAACTGGTGAGCCTTTCTGTTCAATTGCATTTGTAAATAAACTTGCTGATGCATTTAACGAGTGGGTCGTCTTTTTCTTAGGTGTATG
TGTCTGACCTCAGGCCTTTTAGCCATATTTCAGTATGTGGCCTTTTTTGATGTTATGTTTTATCCAGTAGCTTTACTAAGGTATAATTGA
TGTAATAAACTGCATATATTTAAAGTGTATACTTTGACAAATTTTGACATGGTGTATACCTTCGAAACTATGCCACAGTCTGGATGTGTT
TACTGAAACATTTTAATAAGGAAGTTTATTTTTGATAAAGTTATGTTTTTGGATACAATATATTTGTATGGTGAGAGTGATGAATTGTTG
GATCATTTGAATAAAATCTTTTACTAACCCCATGATAAAAGGAGAAGACAACAGTGAGCTTAGAATATCTATAAAGCAAAAAATGTAGTC
TCTTGTTTAAAAAATCTGGAGCGGGAATGCAAGGATACAAAACTTTAGCATGCTTTGAGCAAAAATTTAAACTTACTGGAATCTTTTATA
ATAATGTAAGTGGAATGGAGGATTCTAGGAACTGAGAACTGTATTGGAATAGGTTCAAAATATGTAAGAAATGCTAATGTGGGAGATAAA
AATTTTATTTAGTACTTATTCTGATTATTATTAAAGTAATAATGTGTTCCTTGAGGATAACTTGTCAAATGCCCCAAAGCATAAAGAATA
TAATTCTGAATCCCAAATTCCAAAGACAAGAACTCTGTGTTTGAATTCATTCTGCATATAATTATTTATAAGTATAGATTGTGAATTTTT
CCATGTTCTTAAAATTATTTTTATCTTTTTTCATGGTTGCATAGTGCTCCATTGTTTGGCCTTGGTAATATTTAGTTGATAATTCCATTA
CTGTGTATTTTTCACTTGTTTCTAAGATCAAACATTTTAATATGTGCATGTTATATATAAATATGTAAATTCTGTGATACTCTATGATCA
TCTCTTTCTTTATATTATTTTCATAGACATGAAATAGTTGCTCAGAGATTATGCATTTTAAGACACTCATAGTATATATTGCCAAAGTGG
TTTCCAGAAAGGCACTGCTGGCTTCGACTCCTATAAGCAGCACGTGGGCTTGTTCATCTCACTGCATGTTTATGAAGATACAGTTCTTTT

>13574_13574_1_CCDC109B-LMO7_CCDC109B_chr4_110481592_ENST00000394650_LMO7_chr13_76335068_ENST00000341547_length(amino acids)=1270AA_BP=42
MREPRAWGGRMLQRGLWPWRTRLLPTPGTWRPARPWPLPPPPQDNINVFLKACEQIGLKEAQLFHPGDLQDLSNRVTVKQEETDRRVKNV
LITLYWLGRKAQSNPYYNGPHLNLKAFENLLGQALTKALEDSSFLKRSGRDSGYGDIWCPERGEFLAPPRHHKREDSFESLDSLGSRSLT
SCSSDITLRGGREGFESDTDSEFTFKMQDYNKDDMSYRRISAVEPKTALPFNRFLPNKSRQPSYVPAPLRKKKPDKHEDNRRSWASPVYT
EADGTFSRLFQKIYGENGSKSMSDVSAEDVQNLRQLRYEEMQKIKSQLKEQDQKWQDDLAKWKDRRKSYTSDLQKKKEEREEIEKQALEK
SKRSSKTFKEMLQDRESQNQKSTVPSRRRMYSFDDVLEEGKRPPTMTVSEASYQSERVEEKGATYPSEIPKEDSTTFAKREDRVTTEIQL
PSQSPVEEQSPASLSSLRSRSTQMESTRVSASLPRSYRKTDTVRLTSVVTPRPFGSQTRGISSLPRSYTMDDAWKYNGDVEDIKRTPNNV
VSTPAPSPDASQLASSLSSQKEVAATEEDVTRLPSPTSPFSSLSQDQAATSKATLSSTSGLDLMSESGEGEISPQREVSRSQDQFSDMRI
SINQTPGKSLDFGFTIKWDIPGIFVASVEAGSPAEFSQLQVDDEIIAINNTKFSYNDSKEWEEAMAKAQETGHLVMDVRRYGKAGSPETK
WIDATSGIYNSEKSSNLSVTTDFSESLQSSNIESKEINGIHDESNAFESKASESISLKNLKRRSQFFEQGSSDSVVPDLPVPTISAPSRW
VWDQEEERKRQERWQKEQDRLLQEKYQREQEKLREEWQRAKQEAERENSKYLDEELMVLSSNSMSLTTREPSLATWEATWSEGSKSSDRE
GTRAGEEERRQPQEEVVHEDQGKKPQDQLVIERERKWEQQLQEEQEQKRLQAEAEEQKRPAEEQKRQAEIERETSVRIYQYRRPVDSYDI
PKTEEASSGFLPGDRNKSRSTTELDDYSTNKNGNNKYLDQIGNMTSSQRRSKKEQVPSGAELERQQILQEMRKRTPLHNDNSWIRQRSAS
VNKEPVSLPGIMRRGESLDNLDSPRSNSWRQPPWLNQPTGFYASSSVQDFSRPPPQLVSTSNRAYMRNPSSSVPPPSAGSVKTSTTGVAT
TQSPTPRSHSPSASQSGSQLRNRSVSGKRICSYCNNILGKGAAMIIESLGLCYHLHCFKCVACECDLGGSSSGAEVRIRNHQLYCNDCYL

--------------------------------------------------------------
>13574_13574_2_CCDC109B-LMO7_CCDC109B_chr4_110481592_ENST00000394650_LMO7_chr13_76335068_ENST00000357063_length(transcript)=6734nt_BP=232nt
AGCCGCGGCGCGCTGAGCGAGCAGGCGGGGCGGGAGCGCCCACAGCTCGGAGCCACCAGGCGCTGACGAGGAGCCCGGCTGAGGGAGGAT
GCGCCGCTGACGCCTGCGGGAGCCGCGCGCCTGGGGCGGGAGGATGCTCCAGAGGGGCCTCTGGCCGTGGCGCACGCGGCTGCTGCCGAC
CCCTGGCACCTGGCGCCCAGCGCGCCCGTGGCCGCTGCCGCCTCCGCCCCAGGATAATATAAACGTTTTCTTGAAAGCTTGTGAACAGAT
TGGATTGAAAGAAGCCCAGCTTTTCCATCCTGGAGATCTACAGGATTTATCAAATCGAGTCACTGTCAAGCAAGAAGAGACTGACAGGAG
AGTGAAAAATGTTTTGATAACATTGTACTGGCTGGGAAGAAAAGCACAAAGCAACCCGTACTATAATGGTCCCCATCTTAATTTGAAAGC
GTTTGAGAATCTTTTAGGACAAGCACTGACGAAGGCACTCGAAGACTCCAGCTTCCTGAAAAGAAGTGGCAGGGACAGTGGCTACGGTGA
CATCTGGTGTCCTGAACGTGGAGAATTTCTTGCTCCTCCAAGGCACCATAAGAGAGAAGATTCCTTTGAAAGCTTGGACTCTTTGGGCTC
GAGGTCATTGACAAGCTGCTCCTCTGATATCACGTTGAGAGGGGGGCGTGAAGGTTTTGAAAGTGACACAGATTCGGAATTTACATTTAA
GATGCAGGATTATAATAAAGATGATATGTCGTATCGAAGGATTTCGGCTGTTGAGCCAAAGACTGCGTTACCCTTCAATCGTTTTTTACC
CAACAAAAGTAGACAGCCATCCTATGTACCAGCACCTCTGAGAAAGAAAAAGCCAGACAAACATGAGGATAACAGAAGAAGTTGGGCAAG
CCCGGTTTATACAGAAGCAGATGGAACATTTTCAAGTAATCAGAGGAGGATTTGGGGCACCAATGTGGAGAACTGGCCAACTGTACAAGG
AACTTCAAAGTCCTCTTGTTATTTGGAAGAGGAAAAAGCAAAGACAAGAAGCATACCCAACATTGTAAAGGATGATCTTTATGTGCGCAA
GCTCAGTCCAGTCATGCCAAACCCAGGGAATGCTTTTGATCAGTTTCTTCCCAAATGTTGGACCCCAGAAGATGTGAACTGGAAAAGAAT
AAAAAGGGAAACTTATAAGCCATGGTATAAAGAATTTCAGGGATTCAGTCAGTTTTTACTGCTTCAGGCCCTCCAAACATACTCTGATGA
CATCTTGTCTTCTGAAACACATACCAAAATTGATCCCACTTCTGGCCCAAGGCTCATAACCCGCAGGAAGAATCTCTCTTATGCACCAGG
CTATAGAAGAGATGACCTCGAGATGGCAGCCCTGGATCCTGACTTAGAGAATGATGATTTCTTTGTCAGAAAGACTGGGGCTTTCCATGC
AAATCCATATGTTCTCCGAGCTTTTGAAGACTTTAGAAAGTTCTCTGAGCAAGATGATTCTGTAGAGCGAGATATAATTTTACAGTGTAG
AGAAGGTGAACTTGTACTTCCGGATTTGGAAAAAGATGATATGATTGTTCGCCGAATTCCAGCACAGAAGAAAGAAGTGCCGCTGTCTGG
GGCCCCAGATAGATACCACCCAGTCCCTTTTCCCGAACCCTGGACTCTTCCTCCAGAAATTCAAGCAAAATTTCTCTGTGTACTTGAAAG
GACATGCCCATCCAAAGAAAAAAGTAATAGCTGTAGAATATTAGTTCCTTCATATCGGCAGAAGAAAGATGACATGCTGACACGTAAGAT
TCAGTCCTGGAAACTGGGAACTACCGTGCCTCCCATCAGTTTCACCCCTGGCCCCTGCAGTGAGGCTGACTTGAAGAGATGGGAGGCCAT
CCGGGAGGCCAGCAGACTTAGGCACAAGAAAAGGCTGATGGTGGAGAGACTCTTTCAAAAGATTTATGGTGAGAATGGGAGTAAGTCCAT
GAGTGATGTCAGCGCAGAAGATGTTCAAAACTTGCGTCAGCTGCGTTACGAGGAGATGCAGAAAATAAAATCACAATTAAAAGAACAAGA
TCAGAAATGGCAGGATGACCTTGCAAAATGGAAAGATCGTCGAAAAAGTTACACTTCAGATCTGCAGAAGAAAAAAGAAGAGAGAGAAGA
AATTGAAAAGCAGGCACTTGAGAAGTCTAAGAGAAGCTCTAAGACGTTTAAGGAAATGCTGCAGGACAGGGAATCCCAAAATCAAAAGTC
TACAGTTCCGTCAAGAAGGAGAATGTATTCTTTTGATGATGTGCTGGAGGAAGGAAAGCGACCCCCTACAATGACTGTGTCAGAAGCAAG
TTACCAGAGTGAGAGAGTAGAAGAGAAGGGAGCAACTTATCCTTCAGAAATTCCCAAAGAAGATTCTACCACTTTTGCAAAAAGAGAGGA
CCGTGTAACAACTGAAATTCAGCTTCCTTCTCAAAGTCCTGTGGAAGAACAAAGCCCAGCCTCTTTGTCTTCTCTGCGTTCACGGAGCAC
ACAAATGGAATCAACTCGTGTTTCAGCTTCTCTCCCCAGAAGTTACCGGAAAACTGATACAGTCAGGTTAACATCTGTGGTCACACCAAG
ACCCTTTGGCTCTCAGACAAGGGGAATCTCATCACTCCCCAGATCTTACACGATGGATGATGCTTGGAAGTATAATGGAGATGTTGAAGA
CATTAAGAGAACTCCAAACAATGTGGTCAGCACCCCTGCACCAAGCCCGGACGCAAGCCAACTGGCTTCAAGCTTATCTAGCCAGAAAGA
GGTAGCAGCAACAGAAGAAGATGTGACAAGGCTGCCCTCTCCTACATCCCCCTTCTCATCTCTTTCCCAAGACCAGGCTGCCACTTCTAA
AGCCACATTGTCTTCCACATCTGGTCTTGATTTAATGTCTGAATCTGGAGAAGGGGAAATCTCCCCACAAAGAGAAGTCTCAAGATCCCA
GGATCAGTTCAGTGATATGAGAATCAGCATAAACCAGACGCCTGGGAAGAGTCTTGACTTTGGGTTTACAATAAAATGGGATATTCCTGG
GATCTTCGTAGCATCAGTTGAAGCAGGTAGCCCAGCAGAATTTTCTCAGCTACAAGTAGATGATGAAATTATTGCTATTAACAACACCAA
GTTTTCATATAACGATTCAAAAGAGTGGGAGGAAGCCATGGCTAAGGCTCAAGAAACTGGACACCTAGTGATGGATGTGAGGCGCTATGG
AAAGGCTGGTTCACCTGAAACAAAGTGGATTGATGCAACTTCTGGAATTTACAACTCAGAAAAATCTTCAAATCTATCTGTAACAACTGA
TTTCTCCGAAAGCCTTCAGAGTTCTAATATTGAATCCAAAGAAATCAATGGAATTCATGATGAAAGCAATGCTTTTGAATCAAAAGCATC
TGAATCCATTTCTTTGAAAAACTTAAAAAGGCGATCACAATTTTTTGAACAAGGAAGCTCTGATTCGGTGGTTCCTGATCTTCCAGTTCC
AACCATCAGTGCCCCGAGTCGCTGGGTGTGGGATCAAGAGGAGGAGCGGAAGCGGCAGGAGAGGTGGCAGAAGGAGCAGGACCGCCTACT
GCAGGAAAAATATCAACGTGAGCAGGAGAAACTGAGGGAAGAGTGGCAAAGGGCCAAACAGGAGGCAGAGAGAGAGAATTCCAAGTACTT
GGATGAGGAACTGATGGTCCTAAGCTCAAACAGCATGTCTCTGACCACACGGGAGCCCTCTCTTGCCACCTGGGAAGCTACCTGGAGTGA
AGGGTCCAAGTCTTCAGACAGAGAAGGAACCCGAGCAGGAGAAGAGGAGAGGAGACAGCCACAAGAGGAAGTTGTTCATGAGGACCAAGG
AAAGAAGCCGCAGGATCAGCTTGTTATTGAGAGAGAGAGGAAATGGGAGCAACAGCTTCAGGAAGAGCAAGAGCAAAAGCGGCTTCAGGC
TGAGGCTGAGGAGCAGAAGCGTCCTGCGGAGGAGCAGAAGCGCCAGGCAGAGATAGAGCGGGAAACATCAGTCAGAATATACCAGTACAG
GAGGCCTGTTGATTCCTATGATATACCAAAGACAGAAGAAGCATCTTCAGGTTTTCTTCCTGGTGACAGGAATAAATCCAGATCTACTAC
TGAACTGGATGATTACTCCACAAATAAAAATGGAAACAATAAATATTTAGACCAAATTGGGAACATGACCTCTTCACAGAGGAGATCCAA
GAAAGAACAAGTACCATCAGGAGCAGAATTGGAGAGGCAACAAATCCTTCAGGAAATGAGGAAGAGAACACCCCTTCACAATGACAACAG
CTGGATCCGACAGCGCAGTGCCAGTGTCAACAAAGAGCCTGTTAGTCTTCCTGGGATCATGAGAAGAGGCGAATCTTTAGATAACCTGGA
CTCCCCCCGATCCAATTCTTGGAGACAGCCTCCTTGGCTCAATCAGCCCACAGGATTCTATGCTTCTTCCTCTGTGCAAGACTTTAGTCG
CCCACCACCTCAGCTGGTGTCCACATCAAACCGTGCCTACATGCGGAACCCCTCCTCCAGCGTGCCCCCACCTTCAGCTGGCTCCGTGAA
GACCTCCACCACAGGTGTGGCCACCACACAGTCCCCCACCCCGAGAAGCCATTCCCCTTCAGCTTCACAGTCAGGCTCTCAGCTGCGTAA
CAGTGTGTTGCCTGTGAGTGTGACCTCGGAGGCTCTTCCTCAGGAGCTGAAGTCAGGATCAGAAACCACCAACTGTACTGCAACGACTGC
TATCTCAGATTCAAATCTGGACGGCCAACCGCCATGTGATGTAAGCCTCCATACGAAAGCACTGTTGCAGATAGAAGAAGAGGTGGTTGC
TGCTCATGTAGATCTATAAATATGTGTTGTATGTCTTTTTTGCTTTTTTTTTAAAAAAAAGAATAACTTTTTTTGCCTCTTTAGATTACA
TAGAAGCATTGTAGTCTTGGTAGAACCAGTATTTTTGTTGTTTATTTATAAGGTAATTGTGTGTGGGGAAAAGTGCAGTATTTACCTGTT
GAATTCAGCATCTTGAGAGCACAAGGGAAAAAATAAGAACCTACGAATATTTTTGAGGCAGATAATGATCTAGTTTGACTTTCTAGTTAG
TGGTGTTTTGAAGAGGGTATTTTATTGTTTTTTAAAAAAAGGTTCTTAAACATTATTTGAAATAGTTAATATAAATACATAATTGCATTT
GCTCTGTTTATTGTAATGTATTCTAAATTAATGCAGAACCATATGGAAAATTTCATTAAAATCTATCCCCAAATGTGCTTTCTGTATCCT
TCCTTCTACCTATTATTCTGATTTTTAAAAATGCAGTTAATGTACCATTTATTTGCTTGATGAAGGGAGCTCTATTTTCTTTACCAGAAA
TGTTGCTAAGTAATTCCCAATAGAAAGCTGCTTATTTTCATTAATGAAAAATAACCATGGTTTGTATACTAGAAGTCTTCTTCAGAAACT
GGTGAGCCTTTCTGTTCAATTGCATTTGTAAATAAACTTGCTGATGCATTTAACGAGTGGGTCGTCTTTTTCTTAGGTGTATGTGTCTGA
CCTCAGGCCTTTTAGCCATATTTCAGTATGTGGCCTTTTTTGATGTTATGTTTTATCCAGTAGCTTTACTAAGGTATAATTGATGTAATA
AACTGCATATATTTAAAGTGTATACTTTGACAAATTTTGACATGGTGTATACCTTCGAAACTATGCCACAGTCTGGATGTGTTTACTGAA
ACATTTTAATAAGGAAGTTTATTTTTGATAAAGTTATGTTTTTGGATACAATATATTTGTATGGTGAGAGTGATGAATTGTTGGATCATT
TGAATAAAATCTTTTACTAACCCCATGATAAAAGGAGAAGACAACAGTGAGCTTAGAATATCTATAAAGCAAAAAATGTAGTCTCTTGTT
TAAAAAATCTGGAGCGGGAATGCAAGGATACAAAACTTTAGCATGCTTTGAGCAAAAATTTAAACTTACTGGAATCTTTTATAATAATGT
AAGTGGAATGGAGGATTCTAGGAACTGAGAACTGTATTGGAATAGGTTCAAAATATGTAAGAAATGCTAATGTGGGAGATAAAAATTTTA
TTTAGTACTTATTCTGATTATTATTAAAGTAATAATGTGTTCCTTGAGGATAACTTGTCAAATGCCCCAAAGCATAAAGAATATAATTCT
GAATCCCAAATTCCAAAGACAAGAACTCTGTGTTTGAATTCATTCTGCATATAATTATTTATAAGTATAGATTGTGAATTTTTCCATGTT
CTTAAAATTATTTTTATCTTTTTTCATGGTTGCATAGTGCTCCATTGTTTGGCCTTGGTAATATTTAGTTGATAATTCCATTACTGTGTA
TTTTTCACTTGTTTCTAAGATCAAACATTTTAATATGTGCATGTTATATATAAATATGTAAATTCTGTGATACTCTATGATCATCTCTTT
CTTTATATTATTTTCATAGACATGAAATAGTTGCTCAGAGATTATGCATTTTAAGACACTCATAGTATATATTGCCAAAGTGGTTTCCAG
AAAGGCACTGCTGGCTTCGACTCCTATAAGCAGCACGTGGGCTTGTTCATCTCACTGCATGTTTATGAAGATACAGTTCTTTTGCCTTGT

>13574_13574_2_CCDC109B-LMO7_CCDC109B_chr4_110481592_ENST00000394650_LMO7_chr13_76335068_ENST00000357063_length(amino acids)=1591AA_BP=42
MREPRAWGGRMLQRGLWPWRTRLLPTPGTWRPARPWPLPPPPQDNINVFLKACEQIGLKEAQLFHPGDLQDLSNRVTVKQEETDRRVKNV
LITLYWLGRKAQSNPYYNGPHLNLKAFENLLGQALTKALEDSSFLKRSGRDSGYGDIWCPERGEFLAPPRHHKREDSFESLDSLGSRSLT
SCSSDITLRGGREGFESDTDSEFTFKMQDYNKDDMSYRRISAVEPKTALPFNRFLPNKSRQPSYVPAPLRKKKPDKHEDNRRSWASPVYT
EADGTFSSNQRRIWGTNVENWPTVQGTSKSSCYLEEEKAKTRSIPNIVKDDLYVRKLSPVMPNPGNAFDQFLPKCWTPEDVNWKRIKRET
YKPWYKEFQGFSQFLLLQALQTYSDDILSSETHTKIDPTSGPRLITRRKNLSYAPGYRRDDLEMAALDPDLENDDFFVRKTGAFHANPYV
LRAFEDFRKFSEQDDSVERDIILQCREGELVLPDLEKDDMIVRRIPAQKKEVPLSGAPDRYHPVPFPEPWTLPPEIQAKFLCVLERTCPS
KEKSNSCRILVPSYRQKKDDMLTRKIQSWKLGTTVPPISFTPGPCSEADLKRWEAIREASRLRHKKRLMVERLFQKIYGENGSKSMSDVS
AEDVQNLRQLRYEEMQKIKSQLKEQDQKWQDDLAKWKDRRKSYTSDLQKKKEEREEIEKQALEKSKRSSKTFKEMLQDRESQNQKSTVPS
RRRMYSFDDVLEEGKRPPTMTVSEASYQSERVEEKGATYPSEIPKEDSTTFAKREDRVTTEIQLPSQSPVEEQSPASLSSLRSRSTQMES
TRVSASLPRSYRKTDTVRLTSVVTPRPFGSQTRGISSLPRSYTMDDAWKYNGDVEDIKRTPNNVVSTPAPSPDASQLASSLSSQKEVAAT
EEDVTRLPSPTSPFSSLSQDQAATSKATLSSTSGLDLMSESGEGEISPQREVSRSQDQFSDMRISINQTPGKSLDFGFTIKWDIPGIFVA
SVEAGSPAEFSQLQVDDEIIAINNTKFSYNDSKEWEEAMAKAQETGHLVMDVRRYGKAGSPETKWIDATSGIYNSEKSSNLSVTTDFSES
LQSSNIESKEINGIHDESNAFESKASESISLKNLKRRSQFFEQGSSDSVVPDLPVPTISAPSRWVWDQEEERKRQERWQKEQDRLLQEKY
QREQEKLREEWQRAKQEAERENSKYLDEELMVLSSNSMSLTTREPSLATWEATWSEGSKSSDREGTRAGEEERRQPQEEVVHEDQGKKPQ
DQLVIERERKWEQQLQEEQEQKRLQAEAEEQKRPAEEQKRQAEIERETSVRIYQYRRPVDSYDIPKTEEASSGFLPGDRNKSRSTTELDD
YSTNKNGNNKYLDQIGNMTSSQRRSKKEQVPSGAELERQQILQEMRKRTPLHNDNSWIRQRSASVNKEPVSLPGIMRRGESLDNLDSPRS
NSWRQPPWLNQPTGFYASSSVQDFSRPPPQLVSTSNRAYMRNPSSSVPPPSAGSVKTSTTGVATTQSPTPRSHSPSASQSGSQLRNSVLP

--------------------------------------------------------------
>13574_13574_3_CCDC109B-LMO7_CCDC109B_chr4_110481592_ENST00000394650_LMO7_chr13_76335068_ENST00000377534_length(transcript)=6631nt_BP=232nt
AGCCGCGGCGCGCTGAGCGAGCAGGCGGGGCGGGAGCGCCCACAGCTCGGAGCCACCAGGCGCTGACGAGGAGCCCGGCTGAGGGAGGAT
GCGCCGCTGACGCCTGCGGGAGCCGCGCGCCTGGGGCGGGAGGATGCTCCAGAGGGGCCTCTGGCCGTGGCGCACGCGGCTGCTGCCGAC
CCCTGGCACCTGGCGCCCAGCGCGCCCGTGGCCGCTGCCGCCTCCGCCCCAGGATAATATAAACGTTTTCTTGAAAGCTTGTGAACAGAT
TGGATTGAAAGAAGCCCAGCTTTTCCATCCTGGAGATCTACAGGATTTATCAAATCGAGTCACTGTCAAGCAAGAAGAGACTGACAGGAG
AGTGAAAAATGTTTTGATAACATTGTACTGGCTGGGAAGAAAAGCACAAAGCAACCCGTACTATAATGGTCCCCATCTTAATTTGAAAGC
GTTTGAGAATCTTTTAGGACAAGCACTGACGAAGGCACTCGAAGACTCCAGCTTCCTGAAAAGAAGTGGCAGGGACAGTGGCTACGGTGA
CATCTGGTGTCCTGAACGTGGAGAATTTCTTGCTCCTCCAAGGCACCATAAGAGAGAAGATTCCTTTGAAAGCTTGGACTCTTTGGGCTC
GAGGTCATTGACAAGCTGCTCCTCTGATATCACGTTGAGAGGGGGGCGTGAAGGTTTTGAAAGTGACACAGATTCGGAATTTACATTTAA
GATGCAGGATTATAATAAAGATGATATGTCGTATCGAAGGATTTCGGCTGTTGAGCCAAAGACTGCGTTACCCTTCAATCGTTTTTTACC
CAACAAAAGTAGACAGCCATCCTATGTACCAGCACCTCTGAGAAAGAAAAAGCCAGACAAACATGAGGATAACAGAAGAAGTTGGGCAAG
CCCGGTTTATACAGAAGCAGATGGAACATTTTCAAGTAATCAGAGGAGGATTTGGGGCACCAATGTGGAGAACTGGCCAACTGTACAAGG
AACTTCAAAGTCCTCTTGTTATTTGGAAGAGGAAAAAGCAAAGACAAGAAGCATACCCAACATTGTAAAGGATGATCTTTATGTGCGCAA
GCTCAGTCCAGTCATGCCAAACCCAGGGAATGCTTTTGATCAGTTTCTTCCCAAATGTTGGACCCCAGAAGATGTGAACTGGAAAAGAAT
AAAAAGGGAAACTTATAAGCCATGGTATAAAGAATTTCAGGGATTCAGTCAGTTTTTACTGCTTCAGGCCCTCCAAACATACTCTGATGA
CATCTTGTCTTCTGAAACACATACCAAAATTGATCCCACTTCTGGCCCAAGGCTCATAACCCGCAGGAAGAATCTCTCTTATGCACCAGG
CTATAGAAGAGATGACCTCGAGATGGCAGCCCTGGATCCTGACTTAGAGAATGATGATTTCTTTGTCAGAAAGACTGGGGCTTTCCATGC
AAATCCATATGTTCTCCGAGCTTTTGAAGACTTTAGAAAGTTCTCTGAGCAAGATGATTCTGTAGAGCGAGATATAATTTTACAGTGTAG
AGAAGGTGAACTTGTACTTCCGGATTTGGAAAAAGATGATATGATTGTTCGCCGAATTCCAGCACAGAAGAAAGAAGTGCCGCTGTCTGG
GGCCCCAGATAGATACCACCCAGTCCCTTTTCCCGAACCCTGGACTCTTCCTCCAGAAATTCAAGCAAAATTTCTCTGTGTACTTGAAAG
GACATGCCCATCCAAAGAAAAAAGTAATAGCTGTAGAATATTAGTTCCTTCATATCGGCAGAAGAAAGATGACATGCTGACACGTAAGAT
TCAGTCCTGGAAACTGGGAACTACCGTGCCTCCCATCAGTTTCACCCCTGGCCCCTGCAGTGAGGCTGACTTGAAGAGATGGGAGGCCAT
CCGGGAGGCCAGCAGACTTAGGCACAAGAAAAGGCTGATGGTGGAGAGACTCTTTCAAAAGATTTATGGTGAGAATGGGAGTAAGTCCAT
GAGTGATGTCAGCGCAGAAGATGTTCAAAACTTGCGTCAGCTGCGTTACGAGGAGATGCAGAAAATAAAATCACAATTAAAAGAACAAGA
TCAGAAATGGCAGGATGACCTTGCAAAATGGAAAGATCGTCGAAAAAGTTACACTTCAGATCTGCAGAAGAAAAAAGAAGAGAGAGAAGA
AATTGAAAAGCAGGCACTTGAGAAGTCTAAGAGAAGCTCTAAGACGTTTAAGGAAATGCTGCAGGACAGGGAATCCCAAAATCAAAAGTC
TACAGTTCCGTCAAGAAGGAGAATGTATTCTTTTGATGATGTGCTGGAGGAAGGAAAGCGACCCCCTACAATGACTGTGTCAGAAGCAAG
TTACCAGAGTGAGAGAGTAGAAGAGAAGGGAGCAACTTATCCTTCAGAAATTCCCAAAGAAGATTCTACCACTTTTGCAAAAAGAGAGGA
CCGTGTAACAACTGAAATTCAGCTTCCTTCTCAAAGTCCTGTGGAAGAACAAAGCCCAGCCTCTTTGTCTTCTCTGCGTTCACGGAGCAC
ACAAATGGAATCAACTCGTGTTTCAGCTTCTCTCCCCAGAAGTTACCGGAAAACTGATACAGTCAGGTTAACATCTGTGGTCACACCAAG
ACCCTTTGGCTCTCAGACAAGGGGAATCTCATCACTCCCCAGATCTTACACGATGGATGATGCTTGGAAGTATAATGGAGATGTTGAAGA
CATTAAGAGAACTCCAAACAATGTGGTCAGCACCCCTGCACCAAGCCCGGACGCAAGCCAACTGGCTTCAAGCTTATCTAGCCAGAAAGA
GGTAGCAGCAACAGAAGAAGATGTGACAAGGCTGCCCTCTCCTACATCCCCCTTCTCATCTCTTTCCCAAGACCAGGCTGCCACTTCTAA
AGCCACATTGTCTTCCACATCTGGTCTTGATTTAATGTCTGAATCTGGAGAAGGGGAAATCTCCCCACAAAGAGAAGTCTCAAGATCCCA
GGATCAGTTCAGTGATATGAGAATCAGCATAAACCAGACGCCTGGGAAGAGTCTTGACTTTGGGTTTACAATAAAATGGGATATTCCTGG
GATCTTCGTAGCATCAGTTGAAGCAGGTAGCCCAGCAGAATTTTCTCAGCTACAAGTAGATGATGAAATTATTGCTATTAACAACACCAA
GTTTTCATATAACGATTCAAAAGAGTGGGAGGAAGCCATGGCTAAGGCTCAAGAAACTGGACACCTAGTGATGGATGTGAGGCGCTATGG
AAAGGCTGGTTCACCTGAAACAAAGTGGATTGATGCAACTTCTGGAATTTACAACTCAGAAAAATCTTCAAATCTATCTGTAACAACTGA
TTTCTCCGAAAGCCTTCAGAGTTCTAATATTGAATCCAAAGAAATCAATGGAATTCATGATGAAAGCAATGCTTTTGAATCAAAAGCATC
TGAATCCATTTCTTTGAAAAACTTAAAAAGGCGATCACAATTTTTTGAACAAGGAAGCTCTGATTCGGTGGTTCCTGATCTTCCAGTTCC
AACCATCAGTGCCCCGAGTCGCTGGGTGTGGGATCAAGAGGAGGAGCGGAAGCGGCAGGAGAGGTGGCAGAAGGAGCAGGACCGCCTACT
GCAGGAAAAATATCAACGTGAGCAGGAGAAACTGAGGGAAGAGTGGCAAAGGGCCAAACAGGAGGCAGAGAGAGAGAATTCCAAGTACTT
GGATGAGGAACTGATGGTCCTAAGCTCAAACAGCATGTCTCTGACCACACGGGAGCCCTCTCTTGCCACCTGGGAAGCTACCTGGAGTGA
AGGGTCCAAGTCTTCAGACAGAGAAGGAACCCGAGCAGGAGAAGAGGAGAGGAGACAGCCACAAGAGGAAGTTGTTCATGAGGACCAAGG
AAAGAAGCCGCAGGATCAGCTTGTTATTGAGAGAGAGAGGAAATGGGAGCAACAGCTTCAGGAAGAGCAAGAGCAAAAGCGGCTTCAGGC
TGAGGCTGAGGAGCAGAAGCGTCCTGCGGAGGAGCAGAAGCGCCAGGCAGAGATAGAGCGGGAAACATCAGTCAGAATATACCAGTACAG
GAGGCCTGTTGATTCCTATGATATACCAAAGACAGAAGAAGCATCTTCAGGTTTTCTTCCTGGTGACAGGAATAAATCCAGATCTACTAC
TGAACTGGATGATTACTCCACAAATAAAAATGGAAACAATAAATATTTAGACCAAATTGGGAACATGACCTCTTCACAGAGGAGATCCAA
GAAAGAACAAGTACCATCAGGAGCAGAATTGGAGAGGCAACAAATCCTTCAGGAAATGAGGAAGAGAACACCCCTTCACAATGACAACAG
CTGGATCCGACAGCGCAGTGCCAGTGTCAACAAAGAGCCTGTTAGTCTTCCTGGGATCATGAGAAGAGGCGAATCTTTAGATAACCTGGA
CTCCCCCCGATCCAATTCTTGGAGACAGCCTCCTTGGCTCAATCAGCCCACAGGATTCTATGCTTCTTCCTCTGTGCAAGACTTTAGTCG
CCCACCACCTCAGCTGGTGTCCACATCAAACCGTGCCTACATGCGGAACCCCTCCTCCAGCGTGCCCCCACCTTCAGCTGGCTCCGTGAA
GACCTCCACCACAGGTGTGGCCACCACACAGTCCCCCACCCCGAGAAGCCATTCCCCTTCAGCTTCACAGTCAGGCTCTCAGCTGCGTAA
CAGCTGGACGGCCAACCGCCATGTGATGTAAGCCTCCATACGAAAGCACTGTTGCAGATAGAAGAAGAGGTGGTTGCTGCTCATGTAGAT
CTATAAATATGTGTTGTATGTCTTTTTTGCTTTTTTTTTAAAAAAAAGAATAACTTTTTTTGCCTCTTTAGATTACATAGAAGCATTGTA
GTCTTGGTAGAACCAGTATTTTTGTTGTTTATTTATAAGGTAATTGTGTGTGGGGAAAAGTGCAGTATTTACCTGTTGAATTCAGCATCT
TGAGAGCACAAGGGAAAAAATAAGAACCTACGAATATTTTTGAGGCAGATAATGATCTAGTTTGACTTTCTAGTTAGTGGTGTTTTGAAG
AGGGTATTTTATTGTTTTTTAAAAAAAGGTTCTTAAACATTATTTGAAATAGTTAATATAAATACATAATTGCATTTGCTCTGTTTATTG
TAATGTATTCTAAATTAATGCAGAACCATATGGAAAATTTCATTAAAATCTATCCCCAAATGTGCTTTCTGTATCCTTCCTTCTACCTAT
TATTCTGATTTTTAAAAATGCAGTTAATGTACCATTTATTTGCTTGATGAAGGGAGCTCTATTTTCTTTACCAGAAATGTTGCTAAGTAA
TTCCCAATAGAAAGCTGCTTATTTTCATTAATGAAAAATAACCATGGTTTGTATACTAGAAGTCTTCTTCAGAAACTGGTGAGCCTTTCT
GTTCAATTGCATTTGTAAATAAACTTGCTGATGCATTTAACGAGTGGGTCGTCTTTTTCTTAGGTGTATGTGTCTGACCTCAGGCCTTTT
AGCCATATTTCAGTATGTGGCCTTTTTTGATGTTATGTTTTATCCAGTAGCTTTACTAAGGTATAATTGATGTAATAAACTGCATATATT
TAAAGTGTATACTTTGACAAATTTTGACATGGTGTATACCTTCGAAACTATGCCACAGTCTGGATGTGTTTACTGAAACATTTTAATAAG
GAAGTTTATTTTTGATAAAGTTATGTTTTTGGATACAATATATTTGTATGGTGAGAGTGATGAATTGTTGGATCATTTGAATAAAATCTT
TTACTAACCCCATGATAAAAGGAGAAGACAACAGTGAGCTTAGAATATCTATAAAGCAAAAAATGTAGTCTCTTGTTTAAAAAATCTGGA
GCGGGAATGCAAGGATACAAAACTTTAGCATGCTTTGAGCAAAAATTTAAACTTACTGGAATCTTTTATAATAATGTAAGTGGAATGGAG
GATTCTAGGAACTGAGAACTGTATTGGAATAGGTTCAAAATATGTAAGAAATGCTAATGTGGGAGATAAAAATTTTATTTAGTACTTATT
CTGATTATTATTAAAGTAATAATGTGTTCCTTGAGGATAACTTGTCAAATGCCCCAAAGCATAAAGAATATAATTCTGAATCCCAAATTC
CAAAGACAAGAACTCTGTGTTTGAATTCATTCTGCATATAATTATTTATAAGTATAGATTGTGAATTTTTCCATGTTCTTAAAATTATTT
TTATCTTTTTTCATGGTTGCATAGTGCTCCATTGTTTGGCCTTGGTAATATTTAGTTGATAATTCCATTACTGTGTATTTTTCACTTGTT
TCTAAGATCAAACATTTTAATATGTGCATGTTATATATAAATATGTAAATTCTGTGATACTCTATGATCATCTCTTTCTTTATATTATTT
TCATAGACATGAAATAGTTGCTCAGAGATTATGCATTTTAAGACACTCATAGTATATATTGCCAAAGTGGTTTCCAGAAAGGCACTGCTG
GCTTCGACTCCTATAAGCAGCACGTGGGCTTGTTCATCTCACTGCATGTTTATGAAGATACAGTTCTTTTGCCTTGTTCTCTGCCTGATG

>13574_13574_3_CCDC109B-LMO7_CCDC109B_chr4_110481592_ENST00000394650_LMO7_chr13_76335068_ENST00000377534_length(amino acids)=1535AA_BP=42
MREPRAWGGRMLQRGLWPWRTRLLPTPGTWRPARPWPLPPPPQDNINVFLKACEQIGLKEAQLFHPGDLQDLSNRVTVKQEETDRRVKNV
LITLYWLGRKAQSNPYYNGPHLNLKAFENLLGQALTKALEDSSFLKRSGRDSGYGDIWCPERGEFLAPPRHHKREDSFESLDSLGSRSLT
SCSSDITLRGGREGFESDTDSEFTFKMQDYNKDDMSYRRISAVEPKTALPFNRFLPNKSRQPSYVPAPLRKKKPDKHEDNRRSWASPVYT
EADGTFSSNQRRIWGTNVENWPTVQGTSKSSCYLEEEKAKTRSIPNIVKDDLYVRKLSPVMPNPGNAFDQFLPKCWTPEDVNWKRIKRET
YKPWYKEFQGFSQFLLLQALQTYSDDILSSETHTKIDPTSGPRLITRRKNLSYAPGYRRDDLEMAALDPDLENDDFFVRKTGAFHANPYV
LRAFEDFRKFSEQDDSVERDIILQCREGELVLPDLEKDDMIVRRIPAQKKEVPLSGAPDRYHPVPFPEPWTLPPEIQAKFLCVLERTCPS
KEKSNSCRILVPSYRQKKDDMLTRKIQSWKLGTTVPPISFTPGPCSEADLKRWEAIREASRLRHKKRLMVERLFQKIYGENGSKSMSDVS
AEDVQNLRQLRYEEMQKIKSQLKEQDQKWQDDLAKWKDRRKSYTSDLQKKKEEREEIEKQALEKSKRSSKTFKEMLQDRESQNQKSTVPS
RRRMYSFDDVLEEGKRPPTMTVSEASYQSERVEEKGATYPSEIPKEDSTTFAKREDRVTTEIQLPSQSPVEEQSPASLSSLRSRSTQMES
TRVSASLPRSYRKTDTVRLTSVVTPRPFGSQTRGISSLPRSYTMDDAWKYNGDVEDIKRTPNNVVSTPAPSPDASQLASSLSSQKEVAAT
EEDVTRLPSPTSPFSSLSQDQAATSKATLSSTSGLDLMSESGEGEISPQREVSRSQDQFSDMRISINQTPGKSLDFGFTIKWDIPGIFVA
SVEAGSPAEFSQLQVDDEIIAINNTKFSYNDSKEWEEAMAKAQETGHLVMDVRRYGKAGSPETKWIDATSGIYNSEKSSNLSVTTDFSES
LQSSNIESKEINGIHDESNAFESKASESISLKNLKRRSQFFEQGSSDSVVPDLPVPTISAPSRWVWDQEEERKRQERWQKEQDRLLQEKY
QREQEKLREEWQRAKQEAERENSKYLDEELMVLSSNSMSLTTREPSLATWEATWSEGSKSSDREGTRAGEEERRQPQEEVVHEDQGKKPQ
DQLVIERERKWEQQLQEEQEQKRLQAEAEEQKRPAEEQKRQAEIERETSVRIYQYRRPVDSYDIPKTEEASSGFLPGDRNKSRSTTELDD
YSTNKNGNNKYLDQIGNMTSSQRRSKKEQVPSGAELERQQILQEMRKRTPLHNDNSWIRQRSASVNKEPVSLPGIMRRGESLDNLDSPRS
NSWRQPPWLNQPTGFYASSSVQDFSRPPPQLVSTSNRAYMRNPSSSVPPPSAGSVKTSTTGVATTQSPTPRSHSPSASQSGSQLRNSWTA

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Fusion Gene PPI Analysis for CCDC109B-LMO7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCDC109B-LMO7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCDC109B-LMO7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource