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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXO34-LGALS3 (FusionGDB2 ID:HG55030TG3958)

Fusion Gene Summary for FBXO34-LGALS3

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXO34-LGALS3
Fusion gene ID: hg55030tg3958
HgeneTgene
Gene symbol

FBXO34

LGALS3

Gene ID

55030

3958

Gene nameF-box protein 34galectin 3
SynonymsCGI-301|Fbx34CBP35|GAL3|GALBP|GALIG|L31|LGALS2|MAC2
Cytomap('FBXO34')('LGALS3')

14q22.3

14q22.3

Type of geneprotein-codingprotein-coding
DescriptionF-box only protein 34protein CGI-301galectin-335 kDa lectinIgE-binding proteinMAC-2 antigenadvanced glycation end-product receptor 3carbohydrate-binding protein 35epididymis secretory sperm binding proteingalactose-specific lectin 3laminin-binding proteinlectin L-29lectin, galacto
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000313833, ENST00000440021, 
ENST00000555087, 		ENST00000555087, 
ENST00000313833, ENST00000440021, 
Fusion gene scores* DoF score10 X 5 X 7=3506 X 9 X 4=216
# samples 1411
** MAII scorelog2(14/350*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/216*10)=-0.973527788638809
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXO34 [Title/Abstract] AND LGALS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXO34(55738255)-LGALS3(55606993), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLGALS3

GO:0002548

monocyte chemotaxis

10925302

TgeneLGALS3

GO:0030593

neutrophil chemotaxis

10925302

TgeneLGALS3

GO:0031334

positive regulation of protein complex assembly

24846175

TgeneLGALS3

GO:0045806

negative regulation of endocytosis

19706535

TgeneLGALS3

GO:0048245

eosinophil chemotaxis

10925302

TgeneLGALS3

GO:0048246

macrophage chemotaxis

10925302

TgeneLGALS3

GO:0050918

positive chemotaxis

10925302

TgeneLGALS3

GO:0070232

regulation of T cell apoptotic process

8692888

TgeneLGALS3

GO:0071674

mononuclear cell migration

10925302

TgeneLGALS3

GO:0071677

positive regulation of mononuclear cell migration

10925302

TgeneLGALS3

GO:0090280

positive regulation of calcium ion import

10925302

TgeneLGALS3

GO:1903078

positive regulation of protein localization to plasma membrane

24846175

TgeneLGALS3

GO:2001200

positive regulation of dendritic cell differentiation

16116184

TgeneLGALS3

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

22761016



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-44-4112-01AFBXO34chr14

55738255

-LGALS3chr14

55606993

+
ChimerDB4LUADTCGA-44-4112-01AFBXO34chr14

55738255

+LGALS3chr14

55606993

+
ChimerDB4LUADTCGA-44-4112-01BFBXO34chr14

55738255

+LGALS3chr14

55606993

+
ChimerDB4LUADTCGA-44-4112FBXO34chr14

55738255

+LGALS3chr14

55606992

+
ChimerDB4OVTCGA-59-2355-01AFBXO34chr14

55738255

-LGALS3chr14

55604088

+
ChimerDB4OVTCGA-59-2355-01AFBXO34chr14

55738255

+LGALS3chr14

55604088

+
ChimerDB4OVTCGA-59-2355FBXO34chr14

55738255

+LGALS3chr14

55604087

+
ChimerDB4OVTCGA-59-2355FBXO34chr14

55738255

+LGALS3chr14

55604762

+


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Fusion Gene ORF analysis for FBXO34-LGALS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000313833ENST00000254301FBXO34chr14

55738255

+LGALS3chr14

55606993

+
5UTR-3CDSENST00000313833ENST00000254301FBXO34chr14

55738255

+LGALS3chr14

55606992

+
5UTR-3CDSENST00000313833ENST00000254301FBXO34chr14

55738255

+LGALS3chr14

55604762

+
5UTR-3UTRENST00000313833ENST00000553755FBXO34chr14

55738255

+LGALS3chr14

55606993

+
5UTR-3UTRENST00000313833ENST00000553755FBXO34chr14

55738255

+LGALS3chr14

55606992

+
5UTR-3UTRENST00000313833ENST00000553755FBXO34chr14

55738255

+LGALS3chr14

55604762

+
5UTR-3UTRENST00000313833ENST00000554715FBXO34chr14

55738255

+LGALS3chr14

55606993

+
5UTR-3UTRENST00000313833ENST00000554715FBXO34chr14

55738255

+LGALS3chr14

55606992

+
5UTR-3UTRENST00000313833ENST00000554715FBXO34chr14

55738255

+LGALS3chr14

55604762

+
5UTR-5UTRENST00000313833ENST00000254301FBXO34chr14

55738255

+LGALS3chr14

55604088

+
5UTR-5UTRENST00000313833ENST00000254301FBXO34chr14

55738255

+LGALS3chr14

55604087

+
5UTR-5UTRENST00000313833ENST00000554715FBXO34chr14

55738255

+LGALS3chr14

55604088

+
5UTR-5UTRENST00000313833ENST00000554715FBXO34chr14

55738255

+LGALS3chr14

55604087

+
5UTR-intronENST00000313833ENST00000553755FBXO34chr14

55738255

+LGALS3chr14

55604088

+
5UTR-intronENST00000313833ENST00000553755FBXO34chr14

55738255

+LGALS3chr14

55604087

+
intron-3CDSENST00000440021ENST00000254301FBXO34chr14

55738255

+LGALS3chr14

55606993

+
intron-3CDSENST00000440021ENST00000254301FBXO34chr14

55738255

+LGALS3chr14

55606992

+
intron-3CDSENST00000440021ENST00000254301FBXO34chr14

55738255

+LGALS3chr14

55604762

+
intron-3CDSENST00000555087ENST00000254301FBXO34chr14

55738255

+LGALS3chr14

55606993

+
intron-3CDSENST00000555087ENST00000254301FBXO34chr14

55738255

+LGALS3chr14

55606992

+
intron-3CDSENST00000555087ENST00000254301FBXO34chr14

55738255

+LGALS3chr14

55604762

+
intron-3UTRENST00000440021ENST00000553755FBXO34chr14

55738255

+LGALS3chr14

55606993

+
intron-3UTRENST00000440021ENST00000553755FBXO34chr14

55738255

+LGALS3chr14

55606992

+
intron-3UTRENST00000440021ENST00000553755FBXO34chr14

55738255

+LGALS3chr14

55604762

+
intron-3UTRENST00000440021ENST00000554715FBXO34chr14

55738255

+LGALS3chr14

55606993

+
intron-3UTRENST00000440021ENST00000554715FBXO34chr14

55738255

+LGALS3chr14

55606992

+
intron-3UTRENST00000440021ENST00000554715FBXO34chr14

55738255

+LGALS3chr14

55604762

+
intron-3UTRENST00000555087ENST00000553755FBXO34chr14

55738255

+LGALS3chr14

55606993

+
intron-3UTRENST00000555087ENST00000553755FBXO34chr14

55738255

+LGALS3chr14

55606992

+
intron-3UTRENST00000555087ENST00000553755FBXO34chr14

55738255

+LGALS3chr14

55604762

+
intron-3UTRENST00000555087ENST00000554715FBXO34chr14

55738255

+LGALS3chr14

55606993

+
intron-3UTRENST00000555087ENST00000554715FBXO34chr14

55738255

+LGALS3chr14

55606992

+
intron-3UTRENST00000555087ENST00000554715FBXO34chr14

55738255

+LGALS3chr14

55604762

+
intron-5UTRENST00000440021ENST00000254301FBXO34chr14

55738255

+LGALS3chr14

55604088

+
intron-5UTRENST00000440021ENST00000254301FBXO34chr14

55738255

+LGALS3chr14

55604087

+
intron-5UTRENST00000440021ENST00000554715FBXO34chr14

55738255

+LGALS3chr14

55604088

+
intron-5UTRENST00000440021ENST00000554715FBXO34chr14

55738255

+LGALS3chr14

55604087

+
intron-5UTRENST00000555087ENST00000254301FBXO34chr14

55738255

+LGALS3chr14

55604088

+
intron-5UTRENST00000555087ENST00000254301FBXO34chr14

55738255

+LGALS3chr14

55604087

+
intron-5UTRENST00000555087ENST00000554715FBXO34chr14

55738255

+LGALS3chr14

55604088

+
intron-5UTRENST00000555087ENST00000554715FBXO34chr14

55738255

+LGALS3chr14

55604087

+
intron-intronENST00000440021ENST00000553755FBXO34chr14

55738255

+LGALS3chr14

55604088

+
intron-intronENST00000440021ENST00000553755FBXO34chr14

55738255

+LGALS3chr14

55604087

+
intron-intronENST00000555087ENST00000553755FBXO34chr14

55738255

+LGALS3chr14

55604088

+
intron-intronENST00000555087ENST00000553755FBXO34chr14

55738255

+LGALS3chr14

55604087

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FBXO34-LGALS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FBXO34chr1455738255+LGALS3chr1455604087+6.98E-050.99993026
FBXO34chr1455738255+LGALS3chr1455604087+6.98E-050.99993026
FBXO34chr1455738255+LGALS3chr1455604762+3.36E-070.99999964
FBXO34chr1455738255+LGALS3chr1455606992+1.55E-070.9999999
FBXO34chr1455738255+LGALS3chr1455606992+1.55E-070.9999999
FBXO34chr1455738255+LGALS3chr1455604087+6.98E-050.99993026
FBXO34chr1455738255+LGALS3chr1455604087+6.98E-050.99993026
FBXO34chr1455738255+LGALS3chr1455604762+3.36E-070.99999964
FBXO34chr1455738255+LGALS3chr1455606992+1.55E-070.9999999
FBXO34chr1455738255+LGALS3chr1455606992+1.55E-070.9999999


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FBXO34-LGALS3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:55738255/:55606993)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FBXO34-LGALS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FBXO34-LGALS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXO34-LGALS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXO34-LGALS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0023893Liver Cirrhosis, Experimental2CTD_human
TgeneC0000786Spontaneous abortion1CTD_human
TgeneC0000822Abortion, Tubal1CTD_human
TgeneC0007621Neoplastic Cell Transformation1CTD_human
TgeneC0014859Esophageal Neoplasms1CTD_human
TgeneC0016059Fibrosis1CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0025202melanoma1CTD_human
TgeneC0027051Myocardial Infarction1CTD_human
TgeneC0027540Necrosis1CTD_human
TgeneC0027627Neoplasm Metastasis1CTD_human
TgeneC0027697Nephritis1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC0042373Vascular Diseases1CTD_human
TgeneC0546837Malignant neoplasm of esophagus1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC1536220ST segment elevation myocardial infarction1CTD_human
TgeneC1623038Cirrhosis1CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC3830362Early Pregnancy Loss1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneC4552766Miscarriage1CTD_human