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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCDC40-ANAPC11 (FusionGDB2 ID:HG55036TG51529)

Fusion Gene Summary for CCDC40-ANAPC11

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC40-ANAPC11
Fusion gene ID: hg55036tg51529
HgeneTgene
Gene symbol

CCDC40

ANAPC11

Gene ID

55036

51529

Gene namecoiled-coil domain containing 40anaphase promoting complex subunit 11
SynonymsCFAP172|CILD15|FAP172APC11|Apc11p|HSPC214
Cytomap('CCDC40')('ANAPC11')

17q25.3

17q25.3

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 40anaphase-promoting complex subunit 11APC11 anaphase promoting complex subunit 11 homologanaphase promoting complex subunit 11 (yeast APC11 homolog)cyclosome subunit 11hepatocellular carcinoma-associated RING finger protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000269318, ENST00000374876, 
ENST00000374877, ENST00000397545, 
ENST00000573903, 
Fusion gene scores* DoF score6 X 5 X 4=1205 X 6 X 4=120
# samples 67
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC40 [Title/Abstract] AND ANAPC11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCDC40(78011985)-ANAPC11(79857796), # samples:1
Anticipated loss of major functional domain due to fusion event.CCDC40-ANAPC11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCDC40-ANAPC11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCDC40-ANAPC11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CCDC40-ANAPC11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CCDC40-ANAPC11 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CCDC40-ANAPC11 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneANAPC11

GO:0016567

protein ubiquitination

11739784

TgeneANAPC11

GO:0070979

protein K11-linked ubiquitination

18485873


check buttonFusion gene breakpoints across CCDC40 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ANAPC11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0H7-01ACCDC40chr17

78011985

+ANAPC11chr17

79857796

+


Top

Fusion Gene ORF analysis for CCDC40-ANAPC11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000269318ENST00000357385CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000269318ENST00000392376CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000269318ENST00000571024CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000269318ENST00000572851CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000269318ENST00000574924CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000269318ENST00000575195CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000269318ENST00000577425CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000269318ENST00000578544CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000269318ENST00000579133CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000269318ENST00000583839CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374876ENST00000357385CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374876ENST00000392376CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374876ENST00000571024CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374876ENST00000572851CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374876ENST00000574924CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374876ENST00000575195CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374876ENST00000577425CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374876ENST00000578544CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374876ENST00000579133CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374876ENST00000583839CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374877ENST00000357385CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374877ENST00000392376CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374877ENST00000571024CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374877ENST00000572851CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374877ENST00000574924CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374877ENST00000575195CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374877ENST00000577425CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374877ENST00000578544CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374877ENST00000579133CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000374877ENST00000583839CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000397545ENST00000357385CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000397545ENST00000392376CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000397545ENST00000571024CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000397545ENST00000572851CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000397545ENST00000574924CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000397545ENST00000575195CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000397545ENST00000577425CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000397545ENST00000578544CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000397545ENST00000579133CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-3UTRENST00000397545ENST00000583839CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000269318ENST00000571874CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000269318ENST00000577747CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000269318ENST00000578550CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000269318ENST00000582222CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000269318ENST00000584314CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000374876ENST00000571874CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000374876ENST00000577747CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000374876ENST00000578550CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000374876ENST00000582222CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000374876ENST00000584314CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000374877ENST00000571874CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000374877ENST00000577747CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000374877ENST00000578550CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000374877ENST00000582222CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000374877ENST00000584314CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000397545ENST00000571874CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000397545ENST00000577747CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000397545ENST00000578550CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000397545ENST00000582222CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
5CDS-intronENST00000397545ENST00000584314CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
Frame-shiftENST00000269318ENST00000571570CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
Frame-shiftENST00000269318ENST00000572639CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
Frame-shiftENST00000269318ENST00000579978CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
Frame-shiftENST00000374876ENST00000571570CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
Frame-shiftENST00000374876ENST00000572639CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
Frame-shiftENST00000374876ENST00000579978CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
Frame-shiftENST00000374877ENST00000571570CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
Frame-shiftENST00000374877ENST00000572639CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
Frame-shiftENST00000374877ENST00000579978CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
Frame-shiftENST00000397545ENST00000571570CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
Frame-shiftENST00000397545ENST00000572639CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
Frame-shiftENST00000397545ENST00000579978CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
In-frameENST00000269318ENST00000344877CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
In-frameENST00000374876ENST00000344877CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
In-frameENST00000374877ENST00000344877CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
In-frameENST00000397545ENST00000344877CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-3CDSENST00000573903ENST00000344877CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-3CDSENST00000573903ENST00000571570CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-3CDSENST00000573903ENST00000572639CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-3CDSENST00000573903ENST00000579978CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-3UTRENST00000573903ENST00000357385CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-3UTRENST00000573903ENST00000392376CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-3UTRENST00000573903ENST00000571024CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-3UTRENST00000573903ENST00000572851CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-3UTRENST00000573903ENST00000574924CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-3UTRENST00000573903ENST00000575195CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-3UTRENST00000573903ENST00000577425CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-3UTRENST00000573903ENST00000578544CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-3UTRENST00000573903ENST00000579133CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-3UTRENST00000573903ENST00000583839CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-intronENST00000573903ENST00000571874CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-intronENST00000573903ENST00000577747CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-intronENST00000573903ENST00000578550CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-intronENST00000573903ENST00000582222CCDC40chr17

78011985

+ANAPC11chr17

79857796

+
intron-intronENST00000573903ENST00000584314CCDC40chr17

78011985

+ANAPC11chr17

79857796

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374877CCDC40chr1778011985+ENST00000344877ANAPC11chr1779857796+7341203601120
ENST00000397545CCDC40chr1778011985+ENST00000344877ANAPC11chr1779857796+7341203601120
ENST00000269318CCDC40chr1778011985+ENST00000344877ANAPC11chr1779857796+7181043440115
ENST00000374876CCDC40chr1778011985+ENST00000344877ANAPC11chr1779857796+712983380113

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374877ENST00000344877CCDC40chr1778011985+ANAPC11chr1779857796+0.171743470.82825655
ENST00000397545ENST00000344877CCDC40chr1778011985+ANAPC11chr1779857796+0.171743470.82825655
ENST00000269318ENST00000344877CCDC40chr1778011985+ANAPC11chr1779857796+0.146314380.8536857
ENST00000374876ENST00000344877CCDC40chr1778011985+ANAPC11chr1779857796+0.12721830.8727817

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Fusion Genomic Features for CCDC40-ANAPC11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CCDC40chr1778011985+ANAPC11chr1779857795+0.0073333580.99266666
CCDC40chr1778011985+ANAPC11chr1779857795+0.0073333580.99266666

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for CCDC40-ANAPC11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:78011985/chr17:79857796)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANAPC11chr17:78011985chr17:79857796ENST000003448772434_773685.0Zinc fingerRING-type
TgeneANAPC11chr17:78011985chr17:79857796ENST000003923762434_773685.0Zinc fingerRING-type
TgeneANAPC11chr17:78011985chr17:79857796ENST000005710241334_773685.0Zinc fingerRING-type
TgeneANAPC11chr17:78011985chr17:79857796ENST000005715702434_773685.0Zinc fingerRING-type
TgeneANAPC11chr17:78011985chr17:79857796ENST000005718742434_773685.0Zinc fingerRING-type
TgeneANAPC11chr17:78011985chr17:79857796ENST000005726392434_773685.0Zinc fingerRING-type
TgeneANAPC11chr17:78011985chr17:79857796ENST000005728511334_773685.0Zinc fingerRING-type
TgeneANAPC11chr17:78011985chr17:79857796ENST000005749242434_773685.0Zinc fingerRING-type
TgeneANAPC11chr17:78011985chr17:79857796ENST000005751950234_773685.0Zinc fingerRING-type
TgeneANAPC11chr17:78011985chr17:79857796ENST000005777473534_773685.0Zinc fingerRING-type
TgeneANAPC11chr17:78011985chr17:79857796ENST000005785503534_773685.0Zinc fingerRING-type
TgeneANAPC11chr17:78011985chr17:79857796ENST000005799781334_773685.0Zinc fingerRING-type
TgeneANAPC11chr17:78011985chr17:79857796ENST000005838391334_773685.0Zinc fingerRING-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC40chr17:78011985chr17:79857796ENST00000269318+2111005_105431580.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC40chr17:78011985chr17:79857796ENST00000269318+211293_31931580.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC40chr17:78011985chr17:79857796ENST00000269318+211349_47031580.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC40chr17:78011985chr17:79857796ENST00000269318+211526_62731580.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC40chr17:78011985chr17:79857796ENST00000269318+211684_95031580.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC40chr17:78011985chr17:79857796ENST00000374876+291005_105431479.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC40chr17:78011985chr17:79857796ENST00000374876+29293_31931479.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC40chr17:78011985chr17:79857796ENST00000374876+29349_47031479.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC40chr17:78011985chr17:79857796ENST00000374876+29526_62731479.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC40chr17:78011985chr17:79857796ENST00000374876+29684_95031479.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC40chr17:78011985chr17:79857796ENST00000397545+2201005_1054311143.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC40chr17:78011985chr17:79857796ENST00000397545+220293_319311143.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC40chr17:78011985chr17:79857796ENST00000397545+220349_470311143.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC40chr17:78011985chr17:79857796ENST00000397545+220526_627311143.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC40chr17:78011985chr17:79857796ENST00000397545+220684_950311143.0Coiled coilOntology_term=ECO:0000255
TgeneANAPC11chr17:78011985chr17:79857796ENST000003573852434_77136197.0Zinc fingerRING-type


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Fusion Gene Sequence for CCDC40-ANAPC11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13799_13799_1_CCDC40-ANAPC11_CCDC40_chr17_78011985_ENST00000269318_ANAPC11_chr17_79857796_ENST00000344877_length(transcript)=718nt_BP=104nt
AGCAACGGGAAATGGCGGAACCGGGCGGCGCGGCGGGCCGGTCCCATCCGGAAGATGGATCGGCTTCTGAGGGAGAGAAGGAAGGGAATA
ATGAAAGCCACATGGCAAGGTGCCCGGCGACGACTGCCCGCTGGTGTGGGGCCAGTGCTCCCACTGCTTCCACATGCATTGCATCCTCAA
GTGGCTGCACGCACAGCAGGTGCAGCAGCACTGCCCCATGTGCCGCCAGGAATGGAAGTTCAAGGAGTGAGGCCCGACCTGGCTCTCGCT
GGAGGGGCATCCTGAGACTCCTTCCTCATGCTGGCGCCGATGGCTGCTGGGGACAGCGCCCCTGAGCTGCAACAAGGTGGAAACAAGGGC
TGGAGCTGCGTTTGTTTTGCCATCACTATGTTGACACTTTTATCCAATAAGTGAAAACTCATTAAACTACTCAAATCTTGCTGGAGGCCT
CTGGGTGCCTGTGTTCTCGGCATATAGATGTGGTCTCGGTGTGTTTTGATATGAAAACTCTCATGAATAAACATCTCCGTGAAACGCCAA
GGCCCTCGTCAAACCCTGAGTCATGACTGGGAGGAGAAGGAGCAGGATCAGACGGTAGAGCCTGGGGCATGCTCTTCAGGCATGCTCTTG

>13799_13799_1_CCDC40-ANAPC11_CCDC40_chr17_78011985_ENST00000269318_ANAPC11_chr17_79857796_ENST00000344877_length(amino acids)=115AA_BP=1
MLQLRGAVPSSHRRQHEEGVSGCPSSESQVGPHSLNFHSWRHMGQCCCTCCACSHLRMQCMWKQWEHWPHTSGQSSPGTLPCGFHYSLPS

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>13799_13799_2_CCDC40-ANAPC11_CCDC40_chr17_78011985_ENST00000374876_ANAPC11_chr17_79857796_ENST00000344877_length(transcript)=712nt_BP=98nt
GGGAAATGGCGGAACCGGGCGGCGCGGCGGGCCGGTCCCATCCGGAAGATGGATCGGCTTCTGAGGGAGAGAAGGAAGGGAATAATGAAA
GCCACATGGCAAGGTGCCCGGCGACGACTGCCCGCTGGTGTGGGGCCAGTGCTCCCACTGCTTCCACATGCATTGCATCCTCAAGTGGCT
GCACGCACAGCAGGTGCAGCAGCACTGCCCCATGTGCCGCCAGGAATGGAAGTTCAAGGAGTGAGGCCCGACCTGGCTCTCGCTGGAGGG
GCATCCTGAGACTCCTTCCTCATGCTGGCGCCGATGGCTGCTGGGGACAGCGCCCCTGAGCTGCAACAAGGTGGAAACAAGGGCTGGAGC
TGCGTTTGTTTTGCCATCACTATGTTGACACTTTTATCCAATAAGTGAAAACTCATTAAACTACTCAAATCTTGCTGGAGGCCTCTGGGT
GCCTGTGTTCTCGGCATATAGATGTGGTCTCGGTGTGTTTTGATATGAAAACTCTCATGAATAAACATCTCCGTGAAACGCCAAGGCCCT
CGTCAAACCCTGAGTCATGACTGGGAGGAGAAGGAGCAGGATCAGACGGTAGAGCCTGGGGCATGCTCTTCAGGCATGCTCTTGCCTGCT

>13799_13799_2_CCDC40-ANAPC11_CCDC40_chr17_78011985_ENST00000374876_ANAPC11_chr17_79857796_ENST00000344877_length(amino acids)=113AA_BP=1
MLQLRGAVPSSHRRQHEEGVSGCPSSESQVGPHSLNFHSWRHMGQCCCTCCACSHLRMQCMWKQWEHWPHTSGQSSPGTLPCGFHYSLPS

--------------------------------------------------------------
>13799_13799_3_CCDC40-ANAPC11_CCDC40_chr17_78011985_ENST00000374877_ANAPC11_chr17_79857796_ENST00000344877_length(transcript)=734nt_BP=120nt
GTTGACAGCGTCGCCTAGCAACGGGAAATGGCGGAACCGGGCGGCGCGGCGGGCCGGTCCCATCCGGAAGATGGATCGGCTTCTGAGGGA
GAGAAGGAAGGGAATAATGAAAGCCACATGGCAAGGTGCCCGGCGACGACTGCCCGCTGGTGTGGGGCCAGTGCTCCCACTGCTTCCACA
TGCATTGCATCCTCAAGTGGCTGCACGCACAGCAGGTGCAGCAGCACTGCCCCATGTGCCGCCAGGAATGGAAGTTCAAGGAGTGAGGCC
CGACCTGGCTCTCGCTGGAGGGGCATCCTGAGACTCCTTCCTCATGCTGGCGCCGATGGCTGCTGGGGACAGCGCCCCTGAGCTGCAACA
AGGTGGAAACAAGGGCTGGAGCTGCGTTTGTTTTGCCATCACTATGTTGACACTTTTATCCAATAAGTGAAAACTCATTAAACTACTCAA
ATCTTGCTGGAGGCCTCTGGGTGCCTGTGTTCTCGGCATATAGATGTGGTCTCGGTGTGTTTTGATATGAAAACTCTCATGAATAAACAT
CTCCGTGAAACGCCAAGGCCCTCGTCAAACCCTGAGTCATGACTGGGAGGAGAAGGAGCAGGATCAGACGGTAGAGCCTGGGGCATGCTC
TTCAGGCATGCTCTTGCCTGCTGGATTGCCGGCGGCGGCCCTGGGACCCTCCCTCAGGCTGGCTCTGAGGGACCCTGGCTGTGCAAAGCT

>13799_13799_3_CCDC40-ANAPC11_CCDC40_chr17_78011985_ENST00000374877_ANAPC11_chr17_79857796_ENST00000344877_length(amino acids)=120AA_BP=1
MLQLRGAVPSSHRRQHEEGVSGCPSSESQVGPHSLNFHSWRHMGQCCCTCCACSHLRMQCMWKQWEHWPHTSGQSSPGTLPCGFHYSLPS

--------------------------------------------------------------
>13799_13799_4_CCDC40-ANAPC11_CCDC40_chr17_78011985_ENST00000397545_ANAPC11_chr17_79857796_ENST00000344877_length(transcript)=734nt_BP=120nt
GTTGACAGCGTCGCCTAGCAACGGGAAATGGCGGAACCGGGCGGCGCGGCGGGCCGGTCCCATCCGGAAGATGGATCGGCTTCTGAGGGA
GAGAAGGAAGGGAATAATGAAAGCCACATGGCAAGGTGCCCGGCGACGACTGCCCGCTGGTGTGGGGCCAGTGCTCCCACTGCTTCCACA
TGCATTGCATCCTCAAGTGGCTGCACGCACAGCAGGTGCAGCAGCACTGCCCCATGTGCCGCCAGGAATGGAAGTTCAAGGAGTGAGGCC
CGACCTGGCTCTCGCTGGAGGGGCATCCTGAGACTCCTTCCTCATGCTGGCGCCGATGGCTGCTGGGGACAGCGCCCCTGAGCTGCAACA
AGGTGGAAACAAGGGCTGGAGCTGCGTTTGTTTTGCCATCACTATGTTGACACTTTTATCCAATAAGTGAAAACTCATTAAACTACTCAA
ATCTTGCTGGAGGCCTCTGGGTGCCTGTGTTCTCGGCATATAGATGTGGTCTCGGTGTGTTTTGATATGAAAACTCTCATGAATAAACAT
CTCCGTGAAACGCCAAGGCCCTCGTCAAACCCTGAGTCATGACTGGGAGGAGAAGGAGCAGGATCAGACGGTAGAGCCTGGGGCATGCTC
TTCAGGCATGCTCTTGCCTGCTGGATTGCCGGCGGCGGCCCTGGGACCCTCCCTCAGGCTGGCTCTGAGGGACCCTGGCTGTGCAAAGCT

>13799_13799_4_CCDC40-ANAPC11_CCDC40_chr17_78011985_ENST00000397545_ANAPC11_chr17_79857796_ENST00000344877_length(amino acids)=120AA_BP=1
MLQLRGAVPSSHRRQHEEGVSGCPSSESQVGPHSLNFHSWRHMGQCCCTCCACSHLRMQCMWKQWEHWPHTSGQSSPGTLPCGFHYSLPS

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Fusion Gene PPI Analysis for CCDC40-ANAPC11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCDC40-ANAPC11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCDC40-ANAPC11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCDC40C0022521Kartagener Syndrome1CTD_human
HgeneCCDC40C3151137CILIARY DYSKINESIA, PRIMARY, 151CTD_human;GENOMICS_ENGLAND
HgeneCCDC40C4317124Polynesian Bronchiectasis1CTD_human
HgeneCCDC40C4551906Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus1CTD_human