Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:WIPI1-BPTF (FusionGDB2 ID:HG55062TG2186)

Fusion Gene Summary for WIPI1-BPTF

check button Fusion gene summary
Fusion gene informationFusion gene name: WIPI1-BPTF
Fusion gene ID: hg55062tg2186
HgeneTgene
Gene symbol

WIPI1

BPTF

Gene ID

55062

2186

Gene nameWD repeat domain, phosphoinositide interacting 1bromodomain PHD finger transcription factor
SynonymsATG18|ATG18A|WIPI49FAC1|FALZ|NEDDFL|NURF301
Cytomap('WIPI1')('BPTF')

17q24.2

17q24.2

Type of geneprotein-codingprotein-coding
DescriptionWD repeat domain phosphoinositide-interacting protein 1WIPI-1 alphaatg18 protein homolognucleosome-remodeling factor subunit BPTFbromodomain and PHD domain transcription factorbromodomain and PHD finger-containing transcription factorfetal Alz-50 clone 1 proteinfetal Alz-50 reactive clone 1fetal Alzheimer antigennucleosome remodeling f
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262139, ENST00000546360, 
ENST00000589459, 
Fusion gene scores* DoF score4 X 3 X 3=3623 X 23 X 6=3174
# samples 426
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(26/3174*10)=-3.60971859980673
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WIPI1 [Title/Abstract] AND BPTF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWIPI1(66446869)-BPTF(65955657), # samples:1
Anticipated loss of major functional domain due to fusion event.WIPI1-BPTF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
WIPI1-BPTF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
WIPI1-BPTF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
WIPI1-BPTF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWIPI1

GO:0009267

cellular response to starvation

28561066

HgeneWIPI1

GO:0048203

vesicle targeting, trans-Golgi to endosome

15020712

TgeneBPTF

GO:0000122

negative regulation of transcription by RNA polymerase II

10727212

TgeneBPTF

GO:0006338

chromatin remodeling

14609955


check buttonFusion gene breakpoints across WIPI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across BPTF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0DE-01AWIPI1chr17

66446869

-BPTFchr17

65955657

+


Top

Fusion Gene ORF analysis for WIPI1-BPTF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262139ENST00000577770WIPI1chr17

66446869

-BPTFchr17

65955657

+
5CDS-intronENST00000546360ENST00000577770WIPI1chr17

66446869

-BPTFchr17

65955657

+
5UTR-3CDSENST00000589459ENST00000306378WIPI1chr17

66446869

-BPTFchr17

65955657

+
5UTR-3CDSENST00000589459ENST00000321892WIPI1chr17

66446869

-BPTFchr17

65955657

+
5UTR-3CDSENST00000589459ENST00000335221WIPI1chr17

66446869

-BPTFchr17

65955657

+
5UTR-3CDSENST00000589459ENST00000424123WIPI1chr17

66446869

-BPTFchr17

65955657

+
5UTR-intronENST00000589459ENST00000577770WIPI1chr17

66446869

-BPTFchr17

65955657

+
In-frameENST00000262139ENST00000306378WIPI1chr17

66446869

-BPTFchr17

65955657

+
In-frameENST00000262139ENST00000321892WIPI1chr17

66446869

-BPTFchr17

65955657

+
In-frameENST00000262139ENST00000335221WIPI1chr17

66446869

-BPTFchr17

65955657

+
In-frameENST00000262139ENST00000424123WIPI1chr17

66446869

-BPTFchr17

65955657

+
In-frameENST00000546360ENST00000306378WIPI1chr17

66446869

-BPTFchr17

65955657

+
In-frameENST00000546360ENST00000321892WIPI1chr17

66446869

-BPTFchr17

65955657

+
In-frameENST00000546360ENST00000335221WIPI1chr17

66446869

-BPTFchr17

65955657

+
In-frameENST00000546360ENST00000424123WIPI1chr17

66446869

-BPTFchr17

65955657

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262139WIPI1chr1766446869-ENST00000335221BPTFchr1765955657+326033301169389
ENST00000262139WIPI1chr1766446869-ENST00000321892BPTFchr1765955657+326033301169389
ENST00000262139WIPI1chr1766446869-ENST00000306378BPTFchr1765955657+203533301169389
ENST00000262139WIPI1chr1766446869-ENST00000424123BPTFchr1765955657+117033301169389
ENST00000546360WIPI1chr1766446869-ENST00000335221BPTFchr1765955657+3235308321144370
ENST00000546360WIPI1chr1766446869-ENST00000321892BPTFchr1765955657+3235308321144370
ENST00000546360WIPI1chr1766446869-ENST00000306378BPTFchr1765955657+2010308321144370
ENST00000546360WIPI1chr1766446869-ENST00000424123BPTFchr1765955657+1145308321144371

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262139ENST00000335221WIPI1chr1766446869-BPTFchr1765955657+0.0004493880.99955064
ENST00000262139ENST00000321892WIPI1chr1766446869-BPTFchr1765955657+0.0004493880.99955064
ENST00000262139ENST00000306378WIPI1chr1766446869-BPTFchr1765955657+0.0011842040.9988158
ENST00000262139ENST00000424123WIPI1chr1766446869-BPTFchr1765955657+0.0055546140.9944454
ENST00000546360ENST00000335221WIPI1chr1766446869-BPTFchr1765955657+0.0003251430.9996749
ENST00000546360ENST00000321892WIPI1chr1766446869-BPTFchr1765955657+0.0003251430.9996749
ENST00000546360ENST00000306378WIPI1chr1766446869-BPTFchr1765955657+0.0007576430.9992424
ENST00000546360ENST00000424123WIPI1chr1766446869-BPTFchr1765955657+0.0038866260.9961133

Top

Fusion Genomic Features for WIPI1-BPTF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
WIPI1chr1766446868-BPTFchr1765955656+0.0001755760.99982446
WIPI1chr1766446868-BPTFchr1765955656+0.0001755760.99982446

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for WIPI1-BPTF


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:66446869/chr17:65955657)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWIPI1chr17:66446869chr17:65955657ENST00000262139-3133_42111447.0RepeatNote=WD 1
HgeneWIPI1chr17:66446869chr17:65955657ENST00000262139-31347_88111447.0RepeatNote=WD 2
TgeneBPTFchr17:66446869chr17:65955657ENST0000030637822282706_273226422921.0Coiled coilOntology_term=ECO:0000255
TgeneBPTFchr17:66446869chr17:65955657ENST0000033522124302706_273226252904.0Coiled coilOntology_term=ECO:0000255
TgeneBPTFchr17:66446869chr17:65955657ENST0000030637822282795_281726422921.0Compositional biasNote=Pro-rich
TgeneBPTFchr17:66446869chr17:65955657ENST0000030637822282848_285326422921.0Compositional biasNote=Poly-Lys
TgeneBPTFchr17:66446869chr17:65955657ENST0000032189224302795_281727683047.0Compositional biasNote=Pro-rich
TgeneBPTFchr17:66446869chr17:65955657ENST0000032189224302848_285327683047.0Compositional biasNote=Poly-Lys
TgeneBPTFchr17:66446869chr17:65955657ENST0000033522124302795_281726252904.0Compositional biasNote=Pro-rich
TgeneBPTFchr17:66446869chr17:65955657ENST0000033522124302848_285326252904.0Compositional biasNote=Poly-Lys
TgeneBPTFchr17:66446869chr17:65955657ENST0000030637822282944_301426422921.0DomainBromo
TgeneBPTFchr17:66446869chr17:65955657ENST0000032189224302944_301427683047.0DomainBromo
TgeneBPTFchr17:66446869chr17:65955657ENST0000033522124302944_301426252904.0DomainBromo
TgeneBPTFchr17:66446869chr17:65955657ENST0000030637822282867_291826422921.0Zinc fingerPHD-type 2
TgeneBPTFchr17:66446869chr17:65955657ENST0000032189224302867_291827683047.0Zinc fingerPHD-type 2
TgeneBPTFchr17:66446869chr17:65955657ENST0000033522124302867_291826252904.0Zinc fingerPHD-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWIPI1chr17:66446869chr17:65955657ENST00000262139-313131_173111447.0RepeatNote=WD 4
HgeneWIPI1chr17:66446869chr17:65955657ENST00000262139-313177_216111447.0RepeatNote=WD 5
HgeneWIPI1chr17:66446869chr17:65955657ENST00000262139-313222_261111447.0RepeatNote=WD 6
HgeneWIPI1chr17:66446869chr17:65955657ENST00000262139-313304_343111447.0RepeatNote=WD 7
HgeneWIPI1chr17:66446869chr17:65955657ENST00000262139-31392_126111447.0RepeatNote=WD 3
TgeneBPTFchr17:66446869chr17:65955657ENST0000030637822282022_205026422921.0Coiled coilOntology_term=ECO:0000255
TgeneBPTFchr17:66446869chr17:65955657ENST000003063782228574_60426422921.0Coiled coilOntology_term=ECO:0000255
TgeneBPTFchr17:66446869chr17:65955657ENST000003063782228978_100726422921.0Coiled coilOntology_term=ECO:0000255
TgeneBPTFchr17:66446869chr17:65955657ENST0000032189224302022_205027683047.0Coiled coilOntology_term=ECO:0000255
TgeneBPTFchr17:66446869chr17:65955657ENST0000032189224302706_273227683047.0Coiled coilOntology_term=ECO:0000255
TgeneBPTFchr17:66446869chr17:65955657ENST000003218922430574_60427683047.0Coiled coilOntology_term=ECO:0000255
TgeneBPTFchr17:66446869chr17:65955657ENST000003218922430978_100727683047.0Coiled coilOntology_term=ECO:0000255
TgeneBPTFchr17:66446869chr17:65955657ENST0000033522124302022_205026252904.0Coiled coilOntology_term=ECO:0000255
TgeneBPTFchr17:66446869chr17:65955657ENST000003352212430574_60426252904.0Coiled coilOntology_term=ECO:0000255
TgeneBPTFchr17:66446869chr17:65955657ENST000003352212430978_100726252904.0Coiled coilOntology_term=ECO:0000255
TgeneBPTFchr17:66446869chr17:65955657ENST000003063782228143_18026422921.0Compositional biasNote=Glu-rich
TgeneBPTFchr17:66446869chr17:65955657ENST000003063782228149_18526422921.0Compositional biasNote=Asp-rich
TgeneBPTFchr17:66446869chr17:65955657ENST0000030637822281709_180326422921.0Compositional biasNote=Thr-rich
TgeneBPTFchr17:66446869chr17:65955657ENST0000030637822282338_236126422921.0Compositional biasNote=Thr-rich
TgeneBPTFchr17:66446869chr17:65955657ENST000003218922430143_18027683047.0Compositional biasNote=Glu-rich
TgeneBPTFchr17:66446869chr17:65955657ENST000003218922430149_18527683047.0Compositional biasNote=Asp-rich
TgeneBPTFchr17:66446869chr17:65955657ENST0000032189224301709_180327683047.0Compositional biasNote=Thr-rich
TgeneBPTFchr17:66446869chr17:65955657ENST0000032189224302338_236127683047.0Compositional biasNote=Thr-rich
TgeneBPTFchr17:66446869chr17:65955657ENST000003352212430143_18026252904.0Compositional biasNote=Glu-rich
TgeneBPTFchr17:66446869chr17:65955657ENST000003352212430149_18526252904.0Compositional biasNote=Asp-rich
TgeneBPTFchr17:66446869chr17:65955657ENST0000033522124301709_180326252904.0Compositional biasNote=Thr-rich
TgeneBPTFchr17:66446869chr17:65955657ENST0000033522124302338_236126252904.0Compositional biasNote=Thr-rich
TgeneBPTFchr17:66446869chr17:65955657ENST000003063782228240_30026422921.0DomainDDT
TgeneBPTFchr17:66446869chr17:65955657ENST000003218922430240_30027683047.0DomainDDT
TgeneBPTFchr17:66446869chr17:65955657ENST000003352212430240_30026252904.0DomainDDT
TgeneBPTFchr17:66446869chr17:65955657ENST000003063782228390_43726422921.0Zinc fingerPHD-type 1
TgeneBPTFchr17:66446869chr17:65955657ENST000003218922430390_43727683047.0Zinc fingerPHD-type 1
TgeneBPTFchr17:66446869chr17:65955657ENST000003352212430390_43726252904.0Zinc fingerPHD-type 1


Top

Fusion Gene Sequence for WIPI1-BPTF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99302_99302_1_WIPI1-BPTF_WIPI1_chr17_66446869_ENST00000262139_BPTF_chr17_65955657_ENST00000306378_length(transcript)=2035nt_BP=333nt
ATGGAGGCCGAGGCCGCGGACGCTCCCCCGGGCGGGGTTGAGTCGGCGCTCAGCTGCTTCTCTTTCAACCAGGACTGCACATCCCTAGCA
ACTGGAACTAAAGCCGGGTATAAGCTGTTTTCTCTGAGTTCTGTGGAGCAGCTGGATCAAGTCCACGGAAGCAATGAAATCCCGGACGTC
TACATCGTGGAGCGCCTCTTCTCCAGCAGCCTGGTGGTGGTAGTCAGTCACACAAAACCACGGCAGATGAACGTGTATCACTTCAAGAAA
GGCACAGAGATCTGTAATTACAGCTACTCCAGCAACATCTTGTCCATAAGGCTGAACCGGCAAGAAGAGCTGAAGAGAGACCTGAAAATT
AAGAAAGAAAAAGACCTGATGCAGTTGGCTCAGGCCACAGCAGTAGCTGCACCCTGCCCCCCAGTGACACCAGCTCCTCCAGCCCCTCCA
GCCCCTCCACCTTCACCTCCCCCTCCACCTGCTGTGCAACACACAGGCCTTCTGTCCACGCCCACCTTACCTGCTGCTTCCCAGAAGAGG
AAGCGGGAAGAGGAAAAAGACTCCAGCTCAAAGTCCAAGAAAAAGAAAATGATCTCTACTACCTCAAAGGAAACTAAGAAGGACACAAAG
CTTTACTGTATCTGTAAAACGCCTTATGATGAATCTAAATTTTATATTGGCTGTGATCGGTGTCAGAATTGGTACCATGGGCGCTGCGTT
GGCATCTTGCAAAGTGAGGCAGAGCTCATTGATGAGTATGTCTGTCCACAGTGCCAGTCAACAGAGGATGCCATGACAGTGCTCACGCCA
CTAACAGAGAAGGATTATGAGGGGTTGAAGAGGGTGCTCCGTTCCTTACAGGCCCATAAGATGGCCTGGCCTTTCCTTGAACCAGTAGAC
CCTAATGATGCACCAGATTATTATGGTGTTATTAAGGAACCTATGGACCTTGCCACCATGGAAGAAAGAGTACAAAGACGATATTATGAA
AAGCTGACGGAATTTGTGGCAGATATGACCAAAATTTTTGATAACTGTCGTTACTACAATCCAAGTGACTCCCCATTTTACCAGTGTGCA
GAAGTTCTCGAATCATTCTTTGTACAGAAATTGAAAGGCTTCAAAGCTAGCAGGTCTCATAACAACAAACTGCAGTCTACAGCTTCTTAA
AGTTCAGCGTGTTAACCTAACATAAAACACAGCAAGAATCTGGTTGTCTGAACTATTTTAAATTAAGGAGCCAGATGTTTTTAGTCAGGC
TATCCTGACAAGACTTGACCTAAACTTCGTTTTTATTGGTCATAACAGTCCAATTATATTCTTGGCCAATTTTGTCCAACGGACAAGAAA
AAAGCAAAGTCAACGACACCATTATCTTGTCAAGATCAGATGGTTTTACTATTGTGGCAGAAGCGAGAAAACTTTGTTTATTGAAAAAAA
AAGAAAAAGAAAGCAAGAAAAAAAGATACTATGGGGTCAAGTGTAACTCCATGGAAATGCCACGTCTGCTCTTCAGTGAAGAAGCTGGTT
TAGAGTCTCACAGAAAACTTTTGACTGTATTTATTTATTGTTGCAAAAAAGACGCTTTTTTATTGCTGCCCTCATTTGTCAGCTAATTAT
TTTTTCTTATAAAATCCAGCCCCGGTTACATATAATCATCTGTATCTTATCATGATTCCTGTAGGTAAAAGTACAAGACGACCTCTAGAT
GTCTTTTCTTTCTATGAAAGGAGCTGCTATGTACACATGTGCACACACACACAACTGGGAATCAACAATGAGTTTATTGTTCATGGTAGA
TTAAAATTAAGCTTGCATAAAGGTTGGGCTAAGTGGTCCTGGACTACAGACTCTGTTGCCTTGAATATAACAGTACAATTTGTCAATTAC
TCTGCACCAGGCTAAAATGAGTAAAATCTATTTGAAGGTATCTTGTTTGTAAACATTTGTCAGATTCTAATTTTTTTCTTTTGTATTAAA

>99302_99302_1_WIPI1-BPTF_WIPI1_chr17_66446869_ENST00000262139_BPTF_chr17_65955657_ENST00000306378_length(amino acids)=389AA_BP=110
MEAEAADAPPGGVESALSCFSFNQDCTSLATGTKAGYKLFSLSSVEQLDQVHGSNEIPDVYIVERLFSSSLVVVVSHTKPRQMNVYHFKK
GTEICNYSYSSNILSIRLNRQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKR
KREEEKDSSSKSKKKKMISTTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTP
LTEKDYEGLKRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPSDSPFYQCA

--------------------------------------------------------------
>99302_99302_2_WIPI1-BPTF_WIPI1_chr17_66446869_ENST00000262139_BPTF_chr17_65955657_ENST00000321892_length(transcript)=3260nt_BP=333nt
ATGGAGGCCGAGGCCGCGGACGCTCCCCCGGGCGGGGTTGAGTCGGCGCTCAGCTGCTTCTCTTTCAACCAGGACTGCACATCCCTAGCA
ACTGGAACTAAAGCCGGGTATAAGCTGTTTTCTCTGAGTTCTGTGGAGCAGCTGGATCAAGTCCACGGAAGCAATGAAATCCCGGACGTC
TACATCGTGGAGCGCCTCTTCTCCAGCAGCCTGGTGGTGGTAGTCAGTCACACAAAACCACGGCAGATGAACGTGTATCACTTCAAGAAA
GGCACAGAGATCTGTAATTACAGCTACTCCAGCAACATCTTGTCCATAAGGCTGAACCGGCAAGAAGAGCTGAAGAGAGACCTGAAAATT
AAGAAAGAAAAAGACCTGATGCAGTTGGCTCAGGCCACAGCAGTAGCTGCACCCTGCCCCCCAGTGACACCAGCTCCTCCAGCCCCTCCA
GCCCCTCCACCTTCACCTCCCCCTCCACCTGCTGTGCAACACACAGGCCTTCTGTCCACGCCCACCTTACCTGCTGCTTCCCAGAAGAGG
AAGCGGGAAGAGGAAAAAGACTCCAGCTCAAAGTCCAAGAAAAAGAAAATGATCTCTACTACCTCAAAGGAAACTAAGAAGGACACAAAG
CTTTACTGTATCTGTAAAACGCCTTATGATGAATCTAAATTTTATATTGGCTGTGATCGGTGTCAGAATTGGTACCATGGGCGCTGCGTT
GGCATCTTGCAAAGTGAGGCAGAGCTCATTGATGAGTATGTCTGTCCACAGTGCCAGTCAACAGAGGATGCCATGACAGTGCTCACGCCA
CTAACAGAGAAGGATTATGAGGGGTTGAAGAGGGTGCTCCGTTCCTTACAGGCCCATAAGATGGCCTGGCCTTTCCTTGAACCAGTAGAC
CCTAATGATGCACCAGATTATTATGGTGTTATTAAGGAACCTATGGACCTTGCCACCATGGAAGAAAGAGTACAAAGACGATATTATGAA
AAGCTGACGGAATTTGTGGCAGATATGACCAAAATTTTTGATAACTGTCGTTACTACAATCCAAGTGACTCCCCATTTTACCAGTGTGCA
GAAGTTCTCGAATCATTCTTTGTACAGAAATTGAAAGGCTTCAAAGCTAGCAGGTCTCATAACAACAAACTGCAGTCTACAGCTTCTTAA
AGTTCAGCGTGTTAACCTAACATAAAACACAGCAAGAATCTGGTTGTCTGAACTATTTTAAATTAAGGAGCCAGATGTTTTTAGTCAGGC
TATCCTGACAAGACTTGACCTAAACTTCGTTTTTATTGGTCATAACAGTCCAATTATATTCTTGGCCAATTTTGTCCAACGGACAAGAAA
AAAGCAAAGTCAACGACACCATTATCTTGTCAAGATCAGATGGTTTTACTATTGTGGCAGAAGCGAGAAAACTTTGTTTATTGAAAAAAA
AAGAAAAAGAAAGCAAGAAAAAAAGATACTATGGGGTCAAGTGTAACTCCATGGAAATGCCACGTCTGCTCTTCAGTGAAGAAGCTGGTT
TAGAGTCTCACAGAAAACTTTTGACTGTATTTATTTATTGTTGCAAAAAAGACGCTTTTTTATTGCTGCCCTCATTTGTCAGCTAATTAT
TTTTTCTTATAAAATCCAGCCCCGGTTACATATAATCATCTGTATCTTATCATGATTCCTGTAGGTAAAAGTACAAGACGACCTCTAGAT
GTCTTTTCTTTCTATGAAAGGAGCTGCTATGTACACATGTGCACACACACACAACTGGGAATCAACAATGAGTTTATTGTTCATGGTAGA
TTAAAATTAAGCTTGCATAAAGGTTGGGCTAAGTGGTCCTGGACTACAGACTCTGTTGCCTTGAATATAACAGTACAATTTGTCAATTAC
TCTGCACCAGGCTAAAATGAGTAAAATCTATTTGAAGGTATCTTGTTTGTAAACATTTGTCAGATTCTAATTTTTTTCTTTTGTATTAAA
ATTCAACTATGGATGTATATGAAACAAAATAAATGGAGATAATTTTTCTCCCACAGACAGAGGTGTCTTTGAATGTGCGCTAATGATTAT
CTGTAAGCCTTTGTGGGGAGGGAGGCCTGCAAGGTCATGAAAGGCAGAAGAGTCTAATTGTGCCTGGATTTCTCCAGGACAGCAGTGGCC
CCTCGTTTTATCATTCCCAGTCCATTGTCATCACGTCAGAGAAAAATCTTCAGGGGTGCTAATCCTGTTGCATCAGTTGATCATACTAAC
GAGAACGGTAATGCGACAAGATACACATTGCCTTCATCTGTACATTCTGTGATACCAGGCAAATTACCAATTACACACAGCTACTTATAT
TTTATGAAGGGCATTTTTTAGATGACCTCATCCTCTGTGTTATTTGTTGATTGGGTTTGTTTTCTGTTTGTTGGTTTGTTTGTTTCTTCC
ACGTAAGGAAAAGTAGTGTAAACAGTAGCGAGAAAATGGAAACCACAGAGGAAGATGTATTTTGCATGTTTTTCCTTTCAGTGTTCTTAC
ACGTTGTATCACTGCATTGTGGTAATAGCTTCTATAAAATCTGCCATAGTTGGATTATGCAGCTTTGCAAAAATTTTTACTAGATTTTGC
ACTAACTCATATTAGCTTTGTCCTACCAACTTCTGGAATTTATCTAATTATTGTTTTTCAAAGTTTCTTTCCTTTTAATGTTTCCCTGCT
ATGCAAAACCTTTCCCAGACCTCAGTTTCTTAAAAGAAAGATGTTGCTACAGTTCCCGATTCTTTCTTATTACAGGCTCAGGTGTACAGG
TTATTCTGGGTTAATTTTATCTAATGAAGCCCATTCCTTTTTGTACATAAAGATGTCACTTAAACTTATGCTTACAAACTAAAGACTAAT
CGCTCAATATGAAAACATGAAAAAATTTTTGCTTAAAGTATTAAGATGGAAGTAGTTAAATATGGGTTATTTTGTCCTTTTACTTTTTTA
AAAAATGTTACATATTGTATGCACTGTGCTGATGCAAGAATTCTACATTTTAATGAGTTATAAAATTATTCTGCATCTCATCACGTCACA
GTATTTCTGTACTATTTATTCATATATATAAATATATATGGGCTTAATCATTTAAAATTTGTTGCAGCAAGAACTTTCCTACCTGTAGGC
AATAGATTGCTATGTTTTTAACAAATTGTGGCAAATTCTAAACAGCAATTCTTTTGTACGTAATAGGACATTTCATCCTAGAAAAATAAA

>99302_99302_2_WIPI1-BPTF_WIPI1_chr17_66446869_ENST00000262139_BPTF_chr17_65955657_ENST00000321892_length(amino acids)=389AA_BP=110
MEAEAADAPPGGVESALSCFSFNQDCTSLATGTKAGYKLFSLSSVEQLDQVHGSNEIPDVYIVERLFSSSLVVVVSHTKPRQMNVYHFKK
GTEICNYSYSSNILSIRLNRQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKR
KREEEKDSSSKSKKKKMISTTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTP
LTEKDYEGLKRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPSDSPFYQCA

--------------------------------------------------------------
>99302_99302_3_WIPI1-BPTF_WIPI1_chr17_66446869_ENST00000262139_BPTF_chr17_65955657_ENST00000335221_length(transcript)=3260nt_BP=333nt
ATGGAGGCCGAGGCCGCGGACGCTCCCCCGGGCGGGGTTGAGTCGGCGCTCAGCTGCTTCTCTTTCAACCAGGACTGCACATCCCTAGCA
ACTGGAACTAAAGCCGGGTATAAGCTGTTTTCTCTGAGTTCTGTGGAGCAGCTGGATCAAGTCCACGGAAGCAATGAAATCCCGGACGTC
TACATCGTGGAGCGCCTCTTCTCCAGCAGCCTGGTGGTGGTAGTCAGTCACACAAAACCACGGCAGATGAACGTGTATCACTTCAAGAAA
GGCACAGAGATCTGTAATTACAGCTACTCCAGCAACATCTTGTCCATAAGGCTGAACCGGCAAGAAGAGCTGAAGAGAGACCTGAAAATT
AAGAAAGAAAAAGACCTGATGCAGTTGGCTCAGGCCACAGCAGTAGCTGCACCCTGCCCCCCAGTGACACCAGCTCCTCCAGCCCCTCCA
GCCCCTCCACCTTCACCTCCCCCTCCACCTGCTGTGCAACACACAGGCCTTCTGTCCACGCCCACCTTACCTGCTGCTTCCCAGAAGAGG
AAGCGGGAAGAGGAAAAAGACTCCAGCTCAAAGTCCAAGAAAAAGAAAATGATCTCTACTACCTCAAAGGAAACTAAGAAGGACACAAAG
CTTTACTGTATCTGTAAAACGCCTTATGATGAATCTAAATTTTATATTGGCTGTGATCGGTGTCAGAATTGGTACCATGGGCGCTGCGTT
GGCATCTTGCAAAGTGAGGCAGAGCTCATTGATGAGTATGTCTGTCCACAGTGCCAGTCAACAGAGGATGCCATGACAGTGCTCACGCCA
CTAACAGAGAAGGATTATGAGGGGTTGAAGAGGGTGCTCCGTTCCTTACAGGCCCATAAGATGGCCTGGCCTTTCCTTGAACCAGTAGAC
CCTAATGATGCACCAGATTATTATGGTGTTATTAAGGAACCTATGGACCTTGCCACCATGGAAGAAAGAGTACAAAGACGATATTATGAA
AAGCTGACGGAATTTGTGGCAGATATGACCAAAATTTTTGATAACTGTCGTTACTACAATCCAAGTGACTCCCCATTTTACCAGTGTGCA
GAAGTTCTCGAATCATTCTTTGTACAGAAATTGAAAGGCTTCAAAGCTAGCAGGTCTCATAACAACAAACTGCAGTCTACAGCTTCTTAA
AGTTCAGCGTGTTAACCTAACATAAAACACAGCAAGAATCTGGTTGTCTGAACTATTTTAAATTAAGGAGCCAGATGTTTTTAGTCAGGC
TATCCTGACAAGACTTGACCTAAACTTCGTTTTTATTGGTCATAACAGTCCAATTATATTCTTGGCCAATTTTGTCCAACGGACAAGAAA
AAAGCAAAGTCAACGACACCATTATCTTGTCAAGATCAGATGGTTTTACTATTGTGGCAGAAGCGAGAAAACTTTGTTTATTGAAAAAAA
AAGAAAAAGAAAGCAAGAAAAAAAGATACTATGGGGTCAAGTGTAACTCCATGGAAATGCCACGTCTGCTCTTCAGTGAAGAAGCTGGTT
TAGAGTCTCACAGAAAACTTTTGACTGTATTTATTTATTGTTGCAAAAAAGACGCTTTTTTATTGCTGCCCTCATTTGTCAGCTAATTAT
TTTTTCTTATAAAATCCAGCCCCGGTTACATATAATCATCTGTATCTTATCATGATTCCTGTAGGTAAAAGTACAAGACGACCTCTAGAT
GTCTTTTCTTTCTATGAAAGGAGCTGCTATGTACACATGTGCACACACACACAACTGGGAATCAACAATGAGTTTATTGTTCATGGTAGA
TTAAAATTAAGCTTGCATAAAGGTTGGGCTAAGTGGTCCTGGACTACAGACTCTGTTGCCTTGAATATAACAGTACAATTTGTCAATTAC
TCTGCACCAGGCTAAAATGAGTAAAATCTATTTGAAGGTATCTTGTTTGTAAACATTTGTCAGATTCTAATTTTTTTCTTTTGTATTAAA
ATTCAACTATGGATGTATATGAAACAAAATAAATGGAGATAATTTTTCTCCCACAGACAGAGGTGTCTTTGAATGTGCGCTAATGATTAT
CTGTAAGCCTTTGTGGGGAGGGAGGCCTGCAAGGTCATGAAAGGCAGAAGAGTCTAATTGTGCCTGGATTTCTCCAGGACAGCAGTGGCC
CCTCGTTTTATCATTCCCAGTCCATTGTCATCACGTCAGAGAAAAATCTTCAGGGGTGCTAATCCTGTTGCATCAGTTGATCATACTAAC
GAGAACGGTAATGCGACAAGATACACATTGCCTTCATCTGTACATTCTGTGATACCAGGCAAATTACCAATTACACACAGCTACTTATAT
TTTATGAAGGGCATTTTTTAGATGACCTCATCCTCTGTGTTATTTGTTGATTGGGTTTGTTTTCTGTTTGTTGGTTTGTTTGTTTCTTCC
ACGTAAGGAAAAGTAGTGTAAACAGTAGCGAGAAAATGGAAACCACAGAGGAAGATGTATTTTGCATGTTTTTCCTTTCAGTGTTCTTAC
ACGTTGTATCACTGCATTGTGGTAATAGCTTCTATAAAATCTGCCATAGTTGGATTATGCAGCTTTGCAAAAATTTTTACTAGATTTTGC
ACTAACTCATATTAGCTTTGTCCTACCAACTTCTGGAATTTATCTAATTATTGTTTTTCAAAGTTTCTTTCCTTTTAATGTTTCCCTGCT
ATGCAAAACCTTTCCCAGACCTCAGTTTCTTAAAAGAAAGATGTTGCTACAGTTCCCGATTCTTTCTTATTACAGGCTCAGGTGTACAGG
TTATTCTGGGTTAATTTTATCTAATGAAGCCCATTCCTTTTTGTACATAAAGATGTCACTTAAACTTATGCTTACAAACTAAAGACTAAT
CGCTCAATATGAAAACATGAAAAAATTTTTGCTTAAAGTATTAAGATGGAAGTAGTTAAATATGGGTTATTTTGTCCTTTTACTTTTTTA
AAAAATGTTACATATTGTATGCACTGTGCTGATGCAAGAATTCTACATTTTAATGAGTTATAAAATTATTCTGCATCTCATCACGTCACA
GTATTTCTGTACTATTTATTCATATATATAAATATATATGGGCTTAATCATTTAAAATTTGTTGCAGCAAGAACTTTCCTACCTGTAGGC
AATAGATTGCTATGTTTTTAACAAATTGTGGCAAATTCTAAACAGCAATTCTTTTGTACGTAATAGGACATTTCATCCTAGAAAAATAAA

>99302_99302_3_WIPI1-BPTF_WIPI1_chr17_66446869_ENST00000262139_BPTF_chr17_65955657_ENST00000335221_length(amino acids)=389AA_BP=110
MEAEAADAPPGGVESALSCFSFNQDCTSLATGTKAGYKLFSLSSVEQLDQVHGSNEIPDVYIVERLFSSSLVVVVSHTKPRQMNVYHFKK
GTEICNYSYSSNILSIRLNRQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKR
KREEEKDSSSKSKKKKMISTTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTP
LTEKDYEGLKRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPSDSPFYQCA

--------------------------------------------------------------
>99302_99302_4_WIPI1-BPTF_WIPI1_chr17_66446869_ENST00000262139_BPTF_chr17_65955657_ENST00000424123_length(transcript)=1170nt_BP=333nt
ATGGAGGCCGAGGCCGCGGACGCTCCCCCGGGCGGGGTTGAGTCGGCGCTCAGCTGCTTCTCTTTCAACCAGGACTGCACATCCCTAGCA
ACTGGAACTAAAGCCGGGTATAAGCTGTTTTCTCTGAGTTCTGTGGAGCAGCTGGATCAAGTCCACGGAAGCAATGAAATCCCGGACGTC
TACATCGTGGAGCGCCTCTTCTCCAGCAGCCTGGTGGTGGTAGTCAGTCACACAAAACCACGGCAGATGAACGTGTATCACTTCAAGAAA
GGCACAGAGATCTGTAATTACAGCTACTCCAGCAACATCTTGTCCATAAGGCTGAACCGGCAAGAAGAGCTGAAGAGAGACCTGAAAATT
AAGAAAGAAAAAGACCTGATGCAGTTGGCTCAGGCCACAGCAGTAGCTGCACCCTGCCCCCCAGTGACACCAGCTCCTCCAGCCCCTCCA
GCCCCTCCACCTTCACCTCCCCCTCCACCTGCTGTGCAACACACAGGCCTTCTGTCCACGCCCACCTTACCTGCTGCTTCCCAGAAGAGG
AAGCGGGAAGAGGAAAAAGACTCCAGCTCAAAGTCCAAGAAAAAGAAAATGATCTCTACTACCTCAAAGGAAACTAAGAAGGACACAAAG
CTTTACTGTATCTGTAAAACGCCTTATGATGAATCTAAATTTTATATTGGCTGTGATCGGTGTCAGAATTGGTACCATGGGCGCTGCGTT
GGCATCTTGCAAAGTGAGGCAGAGCTCATTGATGAGTATGTCTGTCCACAGTGCCAGTCAACAGAGGATGCCATGACAGTGCTCACGCCA
CTAACAGAGAAGGATTATGAGGGGTTGAAGAGGGTGCTCCGTTCCTTACAGGCCCATAAGATGGCCTGGCCTTTCCTTGAACCAGTAGAC
CCTAATGATGCACCAGATTATTATGGTGTTATTAAGGAACCTATGGACCTTGCCACCATGGAAGAAAGAGTACAAAGACGATATTATGAA
AAGCTGACGGAATTTGTGGCAGATATGACCAAAATTTTTGATAACTGTCGTTACTACAATCCAAGTGACTCCCCATTTTACCAGTGTGCA
GAAGTTCTCGAATCATTCTTTGTACAGAAATTGAAAGGCTTCAAAGCTAGCAGGTCTCATAACAACAAACTGCAGTCTACAGCTTCTTAA

>99302_99302_4_WIPI1-BPTF_WIPI1_chr17_66446869_ENST00000262139_BPTF_chr17_65955657_ENST00000424123_length(amino acids)=389AA_BP=110
MEAEAADAPPGGVESALSCFSFNQDCTSLATGTKAGYKLFSLSSVEQLDQVHGSNEIPDVYIVERLFSSSLVVVVSHTKPRQMNVYHFKK
GTEICNYSYSSNILSIRLNRQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKR
KREEEKDSSSKSKKKKMISTTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTP
LTEKDYEGLKRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPSDSPFYQCA

--------------------------------------------------------------
>99302_99302_5_WIPI1-BPTF_WIPI1_chr17_66446869_ENST00000546360_BPTF_chr17_65955657_ENST00000306378_length(transcript)=2010nt_BP=308nt
GGGCTGCTGAGGTGGCTGTCGCCGGCTCCGAGCTGCGGCTTCCCGGGCCGAGCCCCCGATGGAGGCCGAGGCCGCGGACGCTCCCCCGGG
CGGGGTTGAGTCGGCGCTCAGCTGCTTCTCTTTCAACCAGGACTGCACATGAAATCCCGGACGTCTACATCGTGGAGCGCCTCTTCTCCA
GCAGCCTGGTGGTGGTAGTCAGTCACACAAAACCACGGCAGATGAACGTGTATCACTTCAAGAAAGGCACAGAGATCTGTAATTACAGCT
ACTCCAGCAACATCTTGTCCATAAGGCTGAACCGGCAAGAAGAGCTGAAGAGAGACCTGAAAATTAAGAAAGAAAAAGACCTGATGCAGT
TGGCTCAGGCCACAGCAGTAGCTGCACCCTGCCCCCCAGTGACACCAGCTCCTCCAGCCCCTCCAGCCCCTCCACCTTCACCTCCCCCTC
CACCTGCTGTGCAACACACAGGCCTTCTGTCCACGCCCACCTTACCTGCTGCTTCCCAGAAGAGGAAGCGGGAAGAGGAAAAAGACTCCA
GCTCAAAGTCCAAGAAAAAGAAAATGATCTCTACTACCTCAAAGGAAACTAAGAAGGACACAAAGCTTTACTGTATCTGTAAAACGCCTT
ATGATGAATCTAAATTTTATATTGGCTGTGATCGGTGTCAGAATTGGTACCATGGGCGCTGCGTTGGCATCTTGCAAAGTGAGGCAGAGC
TCATTGATGAGTATGTCTGTCCACAGTGCCAGTCAACAGAGGATGCCATGACAGTGCTCACGCCACTAACAGAGAAGGATTATGAGGGGT
TGAAGAGGGTGCTCCGTTCCTTACAGGCCCATAAGATGGCCTGGCCTTTCCTTGAACCAGTAGACCCTAATGATGCACCAGATTATTATG
GTGTTATTAAGGAACCTATGGACCTTGCCACCATGGAAGAAAGAGTACAAAGACGATATTATGAAAAGCTGACGGAATTTGTGGCAGATA
TGACCAAAATTTTTGATAACTGTCGTTACTACAATCCAAGTGACTCCCCATTTTACCAGTGTGCAGAAGTTCTCGAATCATTCTTTGTAC
AGAAATTGAAAGGCTTCAAAGCTAGCAGGTCTCATAACAACAAACTGCAGTCTACAGCTTCTTAAAGTTCAGCGTGTTAACCTAACATAA
AACACAGCAAGAATCTGGTTGTCTGAACTATTTTAAATTAAGGAGCCAGATGTTTTTAGTCAGGCTATCCTGACAAGACTTGACCTAAAC
TTCGTTTTTATTGGTCATAACAGTCCAATTATATTCTTGGCCAATTTTGTCCAACGGACAAGAAAAAAGCAAAGTCAACGACACCATTAT
CTTGTCAAGATCAGATGGTTTTACTATTGTGGCAGAAGCGAGAAAACTTTGTTTATTGAAAAAAAAAGAAAAAGAAAGCAAGAAAAAAAG
ATACTATGGGGTCAAGTGTAACTCCATGGAAATGCCACGTCTGCTCTTCAGTGAAGAAGCTGGTTTAGAGTCTCACAGAAAACTTTTGAC
TGTATTTATTTATTGTTGCAAAAAAGACGCTTTTTTATTGCTGCCCTCATTTGTCAGCTAATTATTTTTTCTTATAAAATCCAGCCCCGG
TTACATATAATCATCTGTATCTTATCATGATTCCTGTAGGTAAAAGTACAAGACGACCTCTAGATGTCTTTTCTTTCTATGAAAGGAGCT
GCTATGTACACATGTGCACACACACACAACTGGGAATCAACAATGAGTTTATTGTTCATGGTAGATTAAAATTAAGCTTGCATAAAGGTT
GGGCTAAGTGGTCCTGGACTACAGACTCTGTTGCCTTGAATATAACAGTACAATTTGTCAATTACTCTGCACCAGGCTAAAATGAGTAAA
ATCTATTTGAAGGTATCTTGTTTGTAAACATTTGTCAGATTCTAATTTTTTTCTTTTGTATTAAAATTCAACTATGGATGTATATGAAAC

>99302_99302_5_WIPI1-BPTF_WIPI1_chr17_66446869_ENST00000546360_BPTF_chr17_65955657_ENST00000306378_length(amino acids)=370AA_BP=91
MRLPGPSPRWRPRPRTLPRAGLSRRSAASLSTRTAHEIPDVYIVERLFSSSLVVVVSHTKPRQMNVYHFKKGTEICNYSYSSNILSIRLN
RQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMIS
TTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQAH
KMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPSDSPFYQCAEVLESFFVQKLKGFKASRS

--------------------------------------------------------------
>99302_99302_6_WIPI1-BPTF_WIPI1_chr17_66446869_ENST00000546360_BPTF_chr17_65955657_ENST00000321892_length(transcript)=3235nt_BP=308nt
GGGCTGCTGAGGTGGCTGTCGCCGGCTCCGAGCTGCGGCTTCCCGGGCCGAGCCCCCGATGGAGGCCGAGGCCGCGGACGCTCCCCCGGG
CGGGGTTGAGTCGGCGCTCAGCTGCTTCTCTTTCAACCAGGACTGCACATGAAATCCCGGACGTCTACATCGTGGAGCGCCTCTTCTCCA
GCAGCCTGGTGGTGGTAGTCAGTCACACAAAACCACGGCAGATGAACGTGTATCACTTCAAGAAAGGCACAGAGATCTGTAATTACAGCT
ACTCCAGCAACATCTTGTCCATAAGGCTGAACCGGCAAGAAGAGCTGAAGAGAGACCTGAAAATTAAGAAAGAAAAAGACCTGATGCAGT
TGGCTCAGGCCACAGCAGTAGCTGCACCCTGCCCCCCAGTGACACCAGCTCCTCCAGCCCCTCCAGCCCCTCCACCTTCACCTCCCCCTC
CACCTGCTGTGCAACACACAGGCCTTCTGTCCACGCCCACCTTACCTGCTGCTTCCCAGAAGAGGAAGCGGGAAGAGGAAAAAGACTCCA
GCTCAAAGTCCAAGAAAAAGAAAATGATCTCTACTACCTCAAAGGAAACTAAGAAGGACACAAAGCTTTACTGTATCTGTAAAACGCCTT
ATGATGAATCTAAATTTTATATTGGCTGTGATCGGTGTCAGAATTGGTACCATGGGCGCTGCGTTGGCATCTTGCAAAGTGAGGCAGAGC
TCATTGATGAGTATGTCTGTCCACAGTGCCAGTCAACAGAGGATGCCATGACAGTGCTCACGCCACTAACAGAGAAGGATTATGAGGGGT
TGAAGAGGGTGCTCCGTTCCTTACAGGCCCATAAGATGGCCTGGCCTTTCCTTGAACCAGTAGACCCTAATGATGCACCAGATTATTATG
GTGTTATTAAGGAACCTATGGACCTTGCCACCATGGAAGAAAGAGTACAAAGACGATATTATGAAAAGCTGACGGAATTTGTGGCAGATA
TGACCAAAATTTTTGATAACTGTCGTTACTACAATCCAAGTGACTCCCCATTTTACCAGTGTGCAGAAGTTCTCGAATCATTCTTTGTAC
AGAAATTGAAAGGCTTCAAAGCTAGCAGGTCTCATAACAACAAACTGCAGTCTACAGCTTCTTAAAGTTCAGCGTGTTAACCTAACATAA
AACACAGCAAGAATCTGGTTGTCTGAACTATTTTAAATTAAGGAGCCAGATGTTTTTAGTCAGGCTATCCTGACAAGACTTGACCTAAAC
TTCGTTTTTATTGGTCATAACAGTCCAATTATATTCTTGGCCAATTTTGTCCAACGGACAAGAAAAAAGCAAAGTCAACGACACCATTAT
CTTGTCAAGATCAGATGGTTTTACTATTGTGGCAGAAGCGAGAAAACTTTGTTTATTGAAAAAAAAAGAAAAAGAAAGCAAGAAAAAAAG
ATACTATGGGGTCAAGTGTAACTCCATGGAAATGCCACGTCTGCTCTTCAGTGAAGAAGCTGGTTTAGAGTCTCACAGAAAACTTTTGAC
TGTATTTATTTATTGTTGCAAAAAAGACGCTTTTTTATTGCTGCCCTCATTTGTCAGCTAATTATTTTTTCTTATAAAATCCAGCCCCGG
TTACATATAATCATCTGTATCTTATCATGATTCCTGTAGGTAAAAGTACAAGACGACCTCTAGATGTCTTTTCTTTCTATGAAAGGAGCT
GCTATGTACACATGTGCACACACACACAACTGGGAATCAACAATGAGTTTATTGTTCATGGTAGATTAAAATTAAGCTTGCATAAAGGTT
GGGCTAAGTGGTCCTGGACTACAGACTCTGTTGCCTTGAATATAACAGTACAATTTGTCAATTACTCTGCACCAGGCTAAAATGAGTAAA
ATCTATTTGAAGGTATCTTGTTTGTAAACATTTGTCAGATTCTAATTTTTTTCTTTTGTATTAAAATTCAACTATGGATGTATATGAAAC
AAAATAAATGGAGATAATTTTTCTCCCACAGACAGAGGTGTCTTTGAATGTGCGCTAATGATTATCTGTAAGCCTTTGTGGGGAGGGAGG
CCTGCAAGGTCATGAAAGGCAGAAGAGTCTAATTGTGCCTGGATTTCTCCAGGACAGCAGTGGCCCCTCGTTTTATCATTCCCAGTCCAT
TGTCATCACGTCAGAGAAAAATCTTCAGGGGTGCTAATCCTGTTGCATCAGTTGATCATACTAACGAGAACGGTAATGCGACAAGATACA
CATTGCCTTCATCTGTACATTCTGTGATACCAGGCAAATTACCAATTACACACAGCTACTTATATTTTATGAAGGGCATTTTTTAGATGA
CCTCATCCTCTGTGTTATTTGTTGATTGGGTTTGTTTTCTGTTTGTTGGTTTGTTTGTTTCTTCCACGTAAGGAAAAGTAGTGTAAACAG
TAGCGAGAAAATGGAAACCACAGAGGAAGATGTATTTTGCATGTTTTTCCTTTCAGTGTTCTTACACGTTGTATCACTGCATTGTGGTAA
TAGCTTCTATAAAATCTGCCATAGTTGGATTATGCAGCTTTGCAAAAATTTTTACTAGATTTTGCACTAACTCATATTAGCTTTGTCCTA
CCAACTTCTGGAATTTATCTAATTATTGTTTTTCAAAGTTTCTTTCCTTTTAATGTTTCCCTGCTATGCAAAACCTTTCCCAGACCTCAG
TTTCTTAAAAGAAAGATGTTGCTACAGTTCCCGATTCTTTCTTATTACAGGCTCAGGTGTACAGGTTATTCTGGGTTAATTTTATCTAAT
GAAGCCCATTCCTTTTTGTACATAAAGATGTCACTTAAACTTATGCTTACAAACTAAAGACTAATCGCTCAATATGAAAACATGAAAAAA
TTTTTGCTTAAAGTATTAAGATGGAAGTAGTTAAATATGGGTTATTTTGTCCTTTTACTTTTTTAAAAAATGTTACATATTGTATGCACT
GTGCTGATGCAAGAATTCTACATTTTAATGAGTTATAAAATTATTCTGCATCTCATCACGTCACAGTATTTCTGTACTATTTATTCATAT
ATATAAATATATATGGGCTTAATCATTTAAAATTTGTTGCAGCAAGAACTTTCCTACCTGTAGGCAATAGATTGCTATGTTTTTAACAAA

>99302_99302_6_WIPI1-BPTF_WIPI1_chr17_66446869_ENST00000546360_BPTF_chr17_65955657_ENST00000321892_length(amino acids)=370AA_BP=91
MRLPGPSPRWRPRPRTLPRAGLSRRSAASLSTRTAHEIPDVYIVERLFSSSLVVVVSHTKPRQMNVYHFKKGTEICNYSYSSNILSIRLN
RQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMIS
TTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQAH
KMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPSDSPFYQCAEVLESFFVQKLKGFKASRS

--------------------------------------------------------------
>99302_99302_7_WIPI1-BPTF_WIPI1_chr17_66446869_ENST00000546360_BPTF_chr17_65955657_ENST00000335221_length(transcript)=3235nt_BP=308nt
GGGCTGCTGAGGTGGCTGTCGCCGGCTCCGAGCTGCGGCTTCCCGGGCCGAGCCCCCGATGGAGGCCGAGGCCGCGGACGCTCCCCCGGG
CGGGGTTGAGTCGGCGCTCAGCTGCTTCTCTTTCAACCAGGACTGCACATGAAATCCCGGACGTCTACATCGTGGAGCGCCTCTTCTCCA
GCAGCCTGGTGGTGGTAGTCAGTCACACAAAACCACGGCAGATGAACGTGTATCACTTCAAGAAAGGCACAGAGATCTGTAATTACAGCT
ACTCCAGCAACATCTTGTCCATAAGGCTGAACCGGCAAGAAGAGCTGAAGAGAGACCTGAAAATTAAGAAAGAAAAAGACCTGATGCAGT
TGGCTCAGGCCACAGCAGTAGCTGCACCCTGCCCCCCAGTGACACCAGCTCCTCCAGCCCCTCCAGCCCCTCCACCTTCACCTCCCCCTC
CACCTGCTGTGCAACACACAGGCCTTCTGTCCACGCCCACCTTACCTGCTGCTTCCCAGAAGAGGAAGCGGGAAGAGGAAAAAGACTCCA
GCTCAAAGTCCAAGAAAAAGAAAATGATCTCTACTACCTCAAAGGAAACTAAGAAGGACACAAAGCTTTACTGTATCTGTAAAACGCCTT
ATGATGAATCTAAATTTTATATTGGCTGTGATCGGTGTCAGAATTGGTACCATGGGCGCTGCGTTGGCATCTTGCAAAGTGAGGCAGAGC
TCATTGATGAGTATGTCTGTCCACAGTGCCAGTCAACAGAGGATGCCATGACAGTGCTCACGCCACTAACAGAGAAGGATTATGAGGGGT
TGAAGAGGGTGCTCCGTTCCTTACAGGCCCATAAGATGGCCTGGCCTTTCCTTGAACCAGTAGACCCTAATGATGCACCAGATTATTATG
GTGTTATTAAGGAACCTATGGACCTTGCCACCATGGAAGAAAGAGTACAAAGACGATATTATGAAAAGCTGACGGAATTTGTGGCAGATA
TGACCAAAATTTTTGATAACTGTCGTTACTACAATCCAAGTGACTCCCCATTTTACCAGTGTGCAGAAGTTCTCGAATCATTCTTTGTAC
AGAAATTGAAAGGCTTCAAAGCTAGCAGGTCTCATAACAACAAACTGCAGTCTACAGCTTCTTAAAGTTCAGCGTGTTAACCTAACATAA
AACACAGCAAGAATCTGGTTGTCTGAACTATTTTAAATTAAGGAGCCAGATGTTTTTAGTCAGGCTATCCTGACAAGACTTGACCTAAAC
TTCGTTTTTATTGGTCATAACAGTCCAATTATATTCTTGGCCAATTTTGTCCAACGGACAAGAAAAAAGCAAAGTCAACGACACCATTAT
CTTGTCAAGATCAGATGGTTTTACTATTGTGGCAGAAGCGAGAAAACTTTGTTTATTGAAAAAAAAAGAAAAAGAAAGCAAGAAAAAAAG
ATACTATGGGGTCAAGTGTAACTCCATGGAAATGCCACGTCTGCTCTTCAGTGAAGAAGCTGGTTTAGAGTCTCACAGAAAACTTTTGAC
TGTATTTATTTATTGTTGCAAAAAAGACGCTTTTTTATTGCTGCCCTCATTTGTCAGCTAATTATTTTTTCTTATAAAATCCAGCCCCGG
TTACATATAATCATCTGTATCTTATCATGATTCCTGTAGGTAAAAGTACAAGACGACCTCTAGATGTCTTTTCTTTCTATGAAAGGAGCT
GCTATGTACACATGTGCACACACACACAACTGGGAATCAACAATGAGTTTATTGTTCATGGTAGATTAAAATTAAGCTTGCATAAAGGTT
GGGCTAAGTGGTCCTGGACTACAGACTCTGTTGCCTTGAATATAACAGTACAATTTGTCAATTACTCTGCACCAGGCTAAAATGAGTAAA
ATCTATTTGAAGGTATCTTGTTTGTAAACATTTGTCAGATTCTAATTTTTTTCTTTTGTATTAAAATTCAACTATGGATGTATATGAAAC
AAAATAAATGGAGATAATTTTTCTCCCACAGACAGAGGTGTCTTTGAATGTGCGCTAATGATTATCTGTAAGCCTTTGTGGGGAGGGAGG
CCTGCAAGGTCATGAAAGGCAGAAGAGTCTAATTGTGCCTGGATTTCTCCAGGACAGCAGTGGCCCCTCGTTTTATCATTCCCAGTCCAT
TGTCATCACGTCAGAGAAAAATCTTCAGGGGTGCTAATCCTGTTGCATCAGTTGATCATACTAACGAGAACGGTAATGCGACAAGATACA
CATTGCCTTCATCTGTACATTCTGTGATACCAGGCAAATTACCAATTACACACAGCTACTTATATTTTATGAAGGGCATTTTTTAGATGA
CCTCATCCTCTGTGTTATTTGTTGATTGGGTTTGTTTTCTGTTTGTTGGTTTGTTTGTTTCTTCCACGTAAGGAAAAGTAGTGTAAACAG
TAGCGAGAAAATGGAAACCACAGAGGAAGATGTATTTTGCATGTTTTTCCTTTCAGTGTTCTTACACGTTGTATCACTGCATTGTGGTAA
TAGCTTCTATAAAATCTGCCATAGTTGGATTATGCAGCTTTGCAAAAATTTTTACTAGATTTTGCACTAACTCATATTAGCTTTGTCCTA
CCAACTTCTGGAATTTATCTAATTATTGTTTTTCAAAGTTTCTTTCCTTTTAATGTTTCCCTGCTATGCAAAACCTTTCCCAGACCTCAG
TTTCTTAAAAGAAAGATGTTGCTACAGTTCCCGATTCTTTCTTATTACAGGCTCAGGTGTACAGGTTATTCTGGGTTAATTTTATCTAAT
GAAGCCCATTCCTTTTTGTACATAAAGATGTCACTTAAACTTATGCTTACAAACTAAAGACTAATCGCTCAATATGAAAACATGAAAAAA
TTTTTGCTTAAAGTATTAAGATGGAAGTAGTTAAATATGGGTTATTTTGTCCTTTTACTTTTTTAAAAAATGTTACATATTGTATGCACT
GTGCTGATGCAAGAATTCTACATTTTAATGAGTTATAAAATTATTCTGCATCTCATCACGTCACAGTATTTCTGTACTATTTATTCATAT
ATATAAATATATATGGGCTTAATCATTTAAAATTTGTTGCAGCAAGAACTTTCCTACCTGTAGGCAATAGATTGCTATGTTTTTAACAAA

>99302_99302_7_WIPI1-BPTF_WIPI1_chr17_66446869_ENST00000546360_BPTF_chr17_65955657_ENST00000335221_length(amino acids)=370AA_BP=91
MRLPGPSPRWRPRPRTLPRAGLSRRSAASLSTRTAHEIPDVYIVERLFSSSLVVVVSHTKPRQMNVYHFKKGTEICNYSYSSNILSIRLN
RQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMIS
TTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQAH
KMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPSDSPFYQCAEVLESFFVQKLKGFKASRS

--------------------------------------------------------------
>99302_99302_8_WIPI1-BPTF_WIPI1_chr17_66446869_ENST00000546360_BPTF_chr17_65955657_ENST00000424123_length(transcript)=1145nt_BP=308nt
GGGCTGCTGAGGTGGCTGTCGCCGGCTCCGAGCTGCGGCTTCCCGGGCCGAGCCCCCGATGGAGGCCGAGGCCGCGGACGCTCCCCCGGG
CGGGGTTGAGTCGGCGCTCAGCTGCTTCTCTTTCAACCAGGACTGCACATGAAATCCCGGACGTCTACATCGTGGAGCGCCTCTTCTCCA
GCAGCCTGGTGGTGGTAGTCAGTCACACAAAACCACGGCAGATGAACGTGTATCACTTCAAGAAAGGCACAGAGATCTGTAATTACAGCT
ACTCCAGCAACATCTTGTCCATAAGGCTGAACCGGCAAGAAGAGCTGAAGAGAGACCTGAAAATTAAGAAAGAAAAAGACCTGATGCAGT
TGGCTCAGGCCACAGCAGTAGCTGCACCCTGCCCCCCAGTGACACCAGCTCCTCCAGCCCCTCCAGCCCCTCCACCTTCACCTCCCCCTC
CACCTGCTGTGCAACACACAGGCCTTCTGTCCACGCCCACCTTACCTGCTGCTTCCCAGAAGAGGAAGCGGGAAGAGGAAAAAGACTCCA
GCTCAAAGTCCAAGAAAAAGAAAATGATCTCTACTACCTCAAAGGAAACTAAGAAGGACACAAAGCTTTACTGTATCTGTAAAACGCCTT
ATGATGAATCTAAATTTTATATTGGCTGTGATCGGTGTCAGAATTGGTACCATGGGCGCTGCGTTGGCATCTTGCAAAGTGAGGCAGAGC
TCATTGATGAGTATGTCTGTCCACAGTGCCAGTCAACAGAGGATGCCATGACAGTGCTCACGCCACTAACAGAGAAGGATTATGAGGGGT
TGAAGAGGGTGCTCCGTTCCTTACAGGCCCATAAGATGGCCTGGCCTTTCCTTGAACCAGTAGACCCTAATGATGCACCAGATTATTATG
GTGTTATTAAGGAACCTATGGACCTTGCCACCATGGAAGAAAGAGTACAAAGACGATATTATGAAAAGCTGACGGAATTTGTGGCAGATA
TGACCAAAATTTTTGATAACTGTCGTTACTACAATCCAAGTGACTCCCCATTTTACCAGTGTGCAGAAGTTCTCGAATCATTCTTTGTAC

>99302_99302_8_WIPI1-BPTF_WIPI1_chr17_66446869_ENST00000546360_BPTF_chr17_65955657_ENST00000424123_length(amino acids)=371AA_BP=91
MRLPGPSPRWRPRPRTLPRAGLSRRSAASLSTRTAHEIPDVYIVERLFSSSLVVVVSHTKPRQMNVYHFKKGTEICNYSYSSNILSIRLN
RQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMIS
TTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQAH
KMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPSDSPFYQCAEVLESFFVQKLKGFKASRS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for WIPI1-BPTF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneBPTFchr17:66446869chr17:65955657ENST000003063782228640_7492642.02921.0KEAP1
TgeneBPTFchr17:66446869chr17:65955657ENST000003218922430640_7492768.03047.0KEAP1
TgeneBPTFchr17:66446869chr17:65955657ENST000003352212430640_7492625.02904.0KEAP1
TgeneBPTFchr17:66446869chr17:65955657ENST000003063782228839_9212642.02921.0MAZ
TgeneBPTFchr17:66446869chr17:65955657ENST000003218922430839_9212768.03047.0MAZ
TgeneBPTFchr17:66446869chr17:65955657ENST000003352212430839_9212625.02904.0MAZ


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for WIPI1-BPTF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for WIPI1-BPTF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWIPI1C0023794Lipoidosis3CTD_human
HgeneWIPI1C0008370Cholestasis1CTD_human
TgeneC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneC0005695Bladder Neoplasm1CTD_human
TgeneC3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneC4540327NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND DISTAL LIMB ANOMALIES1GENOMICS_ENGLAND;UNIPROT