Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:AGGF1-RAF1 (FusionGDB2 ID:HG55109TG5894)

Fusion Gene Summary for AGGF1-RAF1

check button Fusion gene summary
Fusion gene informationFusion gene name: AGGF1-RAF1
Fusion gene ID: hg55109tg5894
HgeneTgene
Gene symbol

AGGF1

RAF1

Gene ID

55109

5894

Gene nameangiogenic factor with G-patch and FHA domains 1Raf-1 proto-oncogene, serine/threonine kinase
SynonymsGPATC7|GPATCH7|HSU84971|HUS84971|VG5QCMD1NN|CRAF|NS5|Raf-1|c-Raf
Cytomap('AGGF1')('RAF1')

5q13.3

3p25.2

Type of geneprotein-codingprotein-coding
Descriptionangiogenic factor with G patch and FHA domains 1G patch domain-containing protein 7angiogenic factor VG5Qvasculogenesis gene on 5q proteinRAF proto-oncogene serine/threonine-protein kinaseC-Raf proto-oncogene, serine/threonine kinaseOncogene RAF1proto-oncogene c-RAFraf proto-oncogene serine/threonine protein kinasev-raf-1 murine leukemia viral oncogene homolog 1v-raf-1 murine leukemia
Modification date2020031320200327
UniProtAcc.

P04049

Ensembl transtripts involved in fusion geneENST00000312916, ENST00000503538, 
ENST00000506806, 		ENST00000312916, 
ENST00000503538, ENST00000506806, 
Fusion gene scores* DoF score3 X 2 X 3=1819 X 16 X 7=2128
# samples 318
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(18/2128*10)=-3.56342933917152
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AGGF1 [Title/Abstract] AND RAF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAGGF1(76335544)-RAF1(12641914), # samples:5
Anticipated loss of major functional domain due to fusion event.AGGF1-RAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGGF1-RAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGGF1-RAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AGGF1-RAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAGGF1

GO:0001938

positive regulation of endothelial cell proliferation

14961121

HgeneAGGF1

GO:0007155

cell adhesion

14961121

HgeneAGGF1

GO:0045766

positive regulation of angiogenesis

14961121

TgeneRAF1

GO:0000186

activation of MAPKK activity

10644344

TgeneRAF1

GO:0007190

activation of adenylate cyclase activity

15385642

TgeneRAF1

GO:0008285

negative regulation of cell proliferation

9765203

TgeneRAF1

GO:0031333

negative regulation of protein complex assembly

19667065

TgeneRAF1

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

TgeneRAF1

GO:0043066

negative regulation of apoptotic process

19667065


check buttonFusion gene breakpoints across AGGF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RAF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-CH-5737-01AAGGF1chr5

76335544

+RAF1chr3

12641914

-
ChimerDB4THCATCGA-BJ-A2N7-01AAGGF1chr5

76335544

+RAF1chr3

12641914

-
ChimerDB4THCATCGA-DJ-A2Q4-01AAGGF1chr5

76335544

+RAF1chr3

12641914

-
ChimerDB4THCATCGA-EM-A1CS-01AAGGF1chr5

76335544

+RAF1chr3

12641914

-


Top

Fusion Gene ORF analysis for AGGF1-RAF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000312916ENST00000251849AGGF1chr5

76335544

+RAF1chr3

12641914

-
In-frameENST00000312916ENST00000442415AGGF1chr5

76335544

+RAF1chr3

12641914

-
In-frameENST00000312916ENST00000534997AGGF1chr5

76335544

+RAF1chr3

12641914

-
In-frameENST00000312916ENST00000542177AGGF1chr5

76335544

+RAF1chr3

12641914

-
intron-3CDSENST00000503538ENST00000251849AGGF1chr5

76335544

+RAF1chr3

12641914

-
intron-3CDSENST00000503538ENST00000442415AGGF1chr5

76335544

+RAF1chr3

12641914

-
intron-3CDSENST00000503538ENST00000534997AGGF1chr5

76335544

+RAF1chr3

12641914

-
intron-3CDSENST00000503538ENST00000542177AGGF1chr5

76335544

+RAF1chr3

12641914

-
intron-3CDSENST00000506806ENST00000251849AGGF1chr5

76335544

+RAF1chr3

12641914

-
intron-3CDSENST00000506806ENST00000442415AGGF1chr5

76335544

+RAF1chr3

12641914

-
intron-3CDSENST00000506806ENST00000534997AGGF1chr5

76335544

+RAF1chr3

12641914

-
intron-3CDSENST00000506806ENST00000542177AGGF1chr5

76335544

+RAF1chr3

12641914

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000312916AGGF1chr576335544+ENST00000251849RAF1chr312641914-327812522862364692
ENST00000312916AGGF1chr576335544+ENST00000442415RAF1chr312641914-308112522862364692
ENST00000312916AGGF1chr576335544+ENST00000534997RAF1chr312641914-261212522862364692
ENST00000312916AGGF1chr576335544+ENST00000542177RAF1chr312641914-254612522862364692

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000312916ENST00000251849AGGF1chr576335544+RAF1chr312641914-0.0035566210.99644333
ENST00000312916ENST00000442415AGGF1chr576335544+RAF1chr312641914-0.0052028610.99479717
ENST00000312916ENST00000534997AGGF1chr576335544+RAF1chr312641914-0.004891950.99510807
ENST00000312916ENST00000542177AGGF1chr576335544+RAF1chr312641914-0.0053961920.9946038

Top

Fusion Genomic Features for AGGF1-RAF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for AGGF1-RAF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:76335544/chr3:12641914)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RAF1

P04049

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGGF1chr5:76335544chr3:12641914ENST00000312916+51418_88290715.0Coiled coilOntology_term=ECO:0000255
HgeneAGGF1chr5:76335544chr3:12641914ENST00000312916+51412_15290715.0Compositional biasNote=Poly-Pro
TgeneRAF1chr5:76335544chr3:12641914ENST00000251849617349_609278649.0DomainProtein kinase
TgeneRAF1chr5:76335544chr3:12641914ENST00000442415718349_609298669.0DomainProtein kinase
TgeneRAF1chr5:76335544chr3:12641914ENST00000251849617355_363278649.0Nucleotide bindingATP
TgeneRAF1chr5:76335544chr3:12641914ENST00000442415718355_363298669.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGGF1chr5:76335544chr3:12641914ENST00000506806+1318_880177.0Coiled coilOntology_term=ECO:0000255
HgeneAGGF1chr5:76335544chr3:12641914ENST00000506806+1312_150177.0Compositional biasNote=Poly-Pro
HgeneAGGF1chr5:76335544chr3:12641914ENST00000312916+514434_487290715.0DomainFHA
HgeneAGGF1chr5:76335544chr3:12641914ENST00000312916+514619_665290715.0DomainG-patch
HgeneAGGF1chr5:76335544chr3:12641914ENST00000506806+13434_4870177.0DomainFHA
HgeneAGGF1chr5:76335544chr3:12641914ENST00000506806+13619_6650177.0DomainG-patch
TgeneRAF1chr5:76335544chr3:12641914ENST0000025184961756_131278649.0DomainRBD
TgeneRAF1chr5:76335544chr3:12641914ENST0000044241571856_131298669.0DomainRBD
TgeneRAF1chr5:76335544chr3:12641914ENST00000251849617138_184278649.0Zinc fingerPhorbol-ester/DAG-type
TgeneRAF1chr5:76335544chr3:12641914ENST00000442415718138_184298669.0Zinc fingerPhorbol-ester/DAG-type


Top

Fusion Gene Sequence for AGGF1-RAF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2882_2882_1_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000251849_length(transcript)=3278nt_BP=1252nt
GGTCCCGCCTGCCGCTGGCGCCGTTGTTTCCGGCTCAACTGGGGAGCTGCTGGAGCTCTTCTGGCCTCTGGTTTTCCGACTGCTTATCCG
ACGCTCCTCCCTCTGTCTCTGTAGCTGGAGAAGGTAGTTTCCAGGAAAGTTTTCCGGTTTGCAGGCCGCGCACATCGGGCAGGGGCCATC
CTCGGTCCCCTTGCTCGTTGCTCGCAGCCCCGTTCGGCTACAAGTGAGTTTCAGGGCGTCATGGCCAGGGGCCACCGCGGCCAGCCGGGT
GTGAGGCTGCCTTTCGCTGCCCGCGCGCTCCAGTGGTCTCTGGGTCCGCCGGCGTCCGTTTCGGCCTGAACGCAGCCCCTCCGCGGCGAC
GAGCAGTCTCGCGCCGGAGCTCATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGC
CCAGCTAAGGCGGAAGGTGGAGAAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACAC
AGAACGGCTGTACCAGAACGCAGAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAA
TGAAGATAATAAAAAGTCTGATGTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAA
TGACGTTAGTCTTCCAAATAAAGTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTT
ACAAGTAGAAAATGATGCTTACCCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGA
GCCAGCATCTGCATTAGCAACAGAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATC
ACAGACTGGATTTAGTTATGATGAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTA
TGATCCTTCCACTGGAATTTATTACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGAC
TTCTAGCACAAAACAAAGTAAAGATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAAT
TCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCC
CGTGCCAGCACAAAGAGAGCGGGCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTA
TTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGA
TGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACG
GCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAA
ACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGC
AAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAAC
AGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGA
TAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACAT
CAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAAT
GAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACA
CTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCAC
GTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTG
CTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTG
CCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCCCCACATTCCCCATGCTCAA
GGCCCAGCCTTCTGTAGATGCGCAAGTGGATGTTGATGGTAGTACAAAAAGCAGGGGCCCAGCCCCAGCTGTTGGCTACATGAGTATTTA
GAGGAAGTAAGGTAGCAGGCAGTCCAGCCCTGATGTGGAGACACATGGGATTTTGGAAATCAGCTTCTGGAGGAATGCATGTCACAGGCG
GGACTTTCTTCAGAGAGTGGTGCAGCGCCAGACATTTTGCACATAAGGCACCAAACAGCCCAGGACTGCCGAGACTCTGGCCGCCCGAAG
GAGCCTGCTTTGGTACTATGGAACTTTTCTTAGGGGACACGTCCTCCTTTCACAGCTTCTAAGGTGTCCAGTGCATTGGGATGGTTTTCC
AGGCAAGGCACTCGGCCAATCCGCATCTCAGCCCTCTCAGGGAGCAGTCTTCCATCATGCTGAATTTTGTCTTCCAGGAGCTGCCCCTAT
GGGGCGGGGCCGCAGGGCCAGCCTTGTTTCTCTAACAAACAAACAAACAAACAGCCTTGTTTCTCTAGTCACATCATGTGTATACAAGGA
AGCCAGGAATACAGGTTTTCTTGATGATTTGGGTTTTAATTTTGTTTTTATTGCACCTGACAAAATACAGTTATCTGATGGTCCCTCAAT
TATGTTATTTTAATAAAATAAATTAAATTTAGGTGTAA

>2882_2882_1_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000251849_length(amino acids)=692AA_BP=322
MPARSSGLWVRRRPFRPERSPSAATSSLAPELMASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQ
NAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVEND
AYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTG
IYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQR
ERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL
LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW
SGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA
DCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF

--------------------------------------------------------------
>2882_2882_2_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000442415_length(transcript)=3081nt_BP=1252nt
GGTCCCGCCTGCCGCTGGCGCCGTTGTTTCCGGCTCAACTGGGGAGCTGCTGGAGCTCTTCTGGCCTCTGGTTTTCCGACTGCTTATCCG
ACGCTCCTCCCTCTGTCTCTGTAGCTGGAGAAGGTAGTTTCCAGGAAAGTTTTCCGGTTTGCAGGCCGCGCACATCGGGCAGGGGCCATC
CTCGGTCCCCTTGCTCGTTGCTCGCAGCCCCGTTCGGCTACAAGTGAGTTTCAGGGCGTCATGGCCAGGGGCCACCGCGGCCAGCCGGGT
GTGAGGCTGCCTTTCGCTGCCCGCGCGCTCCAGTGGTCTCTGGGTCCGCCGGCGTCCGTTTCGGCCTGAACGCAGCCCCTCCGCGGCGAC
GAGCAGTCTCGCGCCGGAGCTCATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGC
CCAGCTAAGGCGGAAGGTGGAGAAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACAC
AGAACGGCTGTACCAGAACGCAGAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAA
TGAAGATAATAAAAAGTCTGATGTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAA
TGACGTTAGTCTTCCAAATAAAGTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTT
ACAAGTAGAAAATGATGCTTACCCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGA
GCCAGCATCTGCATTAGCAACAGAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATC
ACAGACTGGATTTAGTTATGATGAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTA
TGATCCTTCCACTGGAATTTATTACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGAC
TTCTAGCACAAAACAAAGTAAAGATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAAT
TCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCC
CGTGCCAGCACAAAGAGAGCGGGCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTA
TTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGA
TGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACG
GCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAA
ACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGC
AAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAAC
AGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGA
TAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACAT
CAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAAT
GAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACA
CTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCAC
GTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTG
CTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTG
CCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCCCCACATTCCCCATGCTCAA
GGCCCAGCCTTCTGTAGATGCGCAAGTGGATGTTGATGGTAGTACAAAAAGCAGGGGCCCAGCCCCAGCTGTTGGCTACATGAGTATTTA
GAGGAAGTAAGGTAGCAGGCAGTCCAGCCCTGATGTGGAGACACATGGGATTTTGGAAATCAGCTTCTGGAGGAATGCATGTCACAGGCG
GGACTTTCTTCAGAGAGTGGTGCAGCGCCAGACATTTTGCACATAAGGCACCAAACAGCCCAGGACTGCCGAGACTCTGGCCGCCCGAAG
GAGCCTGCTTTGGTACTATGGAACTTTTCTTAGGGGACACGTCCTCCTTTCACAGCTTCTAAGGTGTCCAGTGCATTGGGATGGTTTTCC
AGGCAAGGCACTCGGCCAATCCGCATCTCAGCCCTCTCAGGGAGCAGTCTTCCATCATGCTGAATTTTGTCTTCCAGGAGCTGCCCCTAT
GGGGCGGGGCCGCAGGGCCAG

>2882_2882_2_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000442415_length(amino acids)=692AA_BP=322
MPARSSGLWVRRRPFRPERSPSAATSSLAPELMASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQ
NAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVEND
AYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTG
IYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQR
ERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL
LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW
SGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA
DCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF

--------------------------------------------------------------
>2882_2882_3_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000534997_length(transcript)=2612nt_BP=1252nt
GGTCCCGCCTGCCGCTGGCGCCGTTGTTTCCGGCTCAACTGGGGAGCTGCTGGAGCTCTTCTGGCCTCTGGTTTTCCGACTGCTTATCCG
ACGCTCCTCCCTCTGTCTCTGTAGCTGGAGAAGGTAGTTTCCAGGAAAGTTTTCCGGTTTGCAGGCCGCGCACATCGGGCAGGGGCCATC
CTCGGTCCCCTTGCTCGTTGCTCGCAGCCCCGTTCGGCTACAAGTGAGTTTCAGGGCGTCATGGCCAGGGGCCACCGCGGCCAGCCGGGT
GTGAGGCTGCCTTTCGCTGCCCGCGCGCTCCAGTGGTCTCTGGGTCCGCCGGCGTCCGTTTCGGCCTGAACGCAGCCCCTCCGCGGCGAC
GAGCAGTCTCGCGCCGGAGCTCATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGC
CCAGCTAAGGCGGAAGGTGGAGAAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACAC
AGAACGGCTGTACCAGAACGCAGAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAA
TGAAGATAATAAAAAGTCTGATGTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAA
TGACGTTAGTCTTCCAAATAAAGTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTT
ACAAGTAGAAAATGATGCTTACCCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGA
GCCAGCATCTGCATTAGCAACAGAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATC
ACAGACTGGATTTAGTTATGATGAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTA
TGATCCTTCCACTGGAATTTATTACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGAC
TTCTAGCACAAAACAAAGTAAAGATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAAT
TCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCC
CGTGCCAGCACAAAGAGAGCGGGCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTA
TTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGA
TGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACG
GCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAA
ACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGC
AAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAAC
AGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGA
TAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACAT
CAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAAT
GAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACA
CTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCAC
GTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTG
CTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTG
CCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCCCCACATTCCCCATGCTCAA
GG

>2882_2882_3_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000534997_length(amino acids)=692AA_BP=322
MPARSSGLWVRRRPFRPERSPSAATSSLAPELMASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQ
NAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVEND
AYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTG
IYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQR
ERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL
LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW
SGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA
DCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF

--------------------------------------------------------------
>2882_2882_4_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000542177_length(transcript)=2546nt_BP=1252nt
GGTCCCGCCTGCCGCTGGCGCCGTTGTTTCCGGCTCAACTGGGGAGCTGCTGGAGCTCTTCTGGCCTCTGGTTTTCCGACTGCTTATCCG
ACGCTCCTCCCTCTGTCTCTGTAGCTGGAGAAGGTAGTTTCCAGGAAAGTTTTCCGGTTTGCAGGCCGCGCACATCGGGCAGGGGCCATC
CTCGGTCCCCTTGCTCGTTGCTCGCAGCCCCGTTCGGCTACAAGTGAGTTTCAGGGCGTCATGGCCAGGGGCCACCGCGGCCAGCCGGGT
GTGAGGCTGCCTTTCGCTGCCCGCGCGCTCCAGTGGTCTCTGGGTCCGCCGGCGTCCGTTTCGGCCTGAACGCAGCCCCTCCGCGGCGAC
GAGCAGTCTCGCGCCGGAGCTCATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGC
CCAGCTAAGGCGGAAGGTGGAGAAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACAC
AGAACGGCTGTACCAGAACGCAGAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAA
TGAAGATAATAAAAAGTCTGATGTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAA
TGACGTTAGTCTTCCAAATAAAGTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTT
ACAAGTAGAAAATGATGCTTACCCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGA
GCCAGCATCTGCATTAGCAACAGAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATC
ACAGACTGGATTTAGTTATGATGAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTA
TGATCCTTCCACTGGAATTTATTACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGAC
TTCTAGCACAAAACAAAGTAAAGATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAAT
TCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCC
CGTGCCAGCACAAAGAGAGCGGGCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTA
TTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGA
TGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACG
GCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAA
ACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGC
AAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAAC
AGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGA
TAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACAT
CAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAAT
GAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACA
CTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCAC
GTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTG
CTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTG
CCTTCTTTTCTATCCCTTTGGGCCCT

>2882_2882_4_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000542177_length(amino acids)=692AA_BP=322
MPARSSGLWVRRRPFRPERSPSAATSSLAPELMASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQ
NAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVEND
AYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTG
IYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQR
ERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL
LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW
SGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA
DCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for AGGF1-RAF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRAF1chr5:76335544chr3:12641914ENST00000251849617331_349278.0649.0PEBP1/RKIP
TgeneRAF1chr5:76335544chr3:12641914ENST00000442415718331_349298.0669.0PEBP1/RKIP


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for AGGF1-RAF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRAF1P04049DB08896RegorafenibInhibitorSmall moleculeApproved
TgeneRAF1P04049DB08896RegorafenibInhibitorSmall moleculeApproved
TgeneRAF1P04049DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
TgeneRAF1P04049DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
TgeneRAF1P04049DB08862CholecystokininAgonistSmall moleculeApproved|Investigational
TgeneRAF1P04049DB08862CholecystokininAgonistSmall moleculeApproved|Investigational
TgeneRAF1P04049DB08912DabrafenibAntagonist|InhibitorSmall moleculeApproved|Investigational
TgeneRAF1P04049DB08912DabrafenibAntagonist|InhibitorSmall moleculeApproved|Investigational
TgeneRAF1P04049DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneRAF1P04049DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

Top

Related Diseases for AGGF1-RAF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAGGF1C0022739Klippel-Trenaunay-Weber Syndrome2ORPHANET;UNIPROT
TgeneC0028326Noonan Syndrome10CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0175704LEOPARD Syndrome7CLINGEN;CTD_human;GENOMICS_ENGLAND
TgeneC1969057Noonan Syndrome 54CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC1969056LEOPARD SYNDROME 23CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0007194Hypertrophic Cardiomyopathy2CTD_human
TgeneC0041409Turner Syndrome, Male2CTD_human
TgeneC1519086Pilomyxoid astrocytoma2ORPHANET
TgeneC1527404Female Pseudo-Turner Syndrome2CTD_human
TgeneC4551472Hypertrophic obstructive cardiomyopathy2CTD_human
TgeneC4551602Noonan Syndrome 12CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneC0007193Cardiomyopathy, Dilated1CTD_human
TgeneC0017638Glioma1CTD_human
TgeneC0020429Hyperalgesia1CTD_human
TgeneC0022665Kidney Neoplasm1CTD_human
TgeneC0023903Liver neoplasms1CTD_human
TgeneC0024121Lung Neoplasms1CTD_human
TgeneC0242379Malignant neoplasm of lung1CTD_human
TgeneC0259783mixed gliomas1CTD_human
TgeneC0340427Familial dilated cardiomyopathy1ORPHANET
TgeneC0345904Malignant neoplasm of liver1CTD_human
TgeneC0345967Malignant mesothelioma1CTD_human
TgeneC0458247Allodynia1CTD_human
TgeneC0555198Malignant Glioma1CTD_human
TgeneC0587248Costello syndrome (disorder)1CLINGEN
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0740457Malignant neoplasm of kidney1CTD_human
TgeneC0751211Hyperalgesia, Primary1CTD_human
TgeneC0751212Hyperalgesia, Secondary1CTD_human
TgeneC0751213Tactile Allodynia1CTD_human
TgeneC0751214Hyperalgesia, Thermal1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1275081Cardio-facio-cutaneous syndrome1CLINGEN
TgeneC1449563Cardiomyopathy, Familial Idiopathic1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC2936719Mechanical Allodynia1CTD_human
TgeneC4014656CARDIOMYOPATHY, DILATED, 1NN1CTD_human;UNIPROT
TgeneC4551484Leopard Syndrome 11CTD_human;GENOMICS_ENGLAND
TgeneC4704874Mammary Carcinoma, Human1CTD_human
TgeneC4721610Carcinoma, Ovarian Epithelial1CTD_human