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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGEF10L-ORM1 (FusionGDB2 ID:HG55160TG5004)

Fusion Gene Summary for ARHGEF10L-ORM1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF10L-ORM1
Fusion gene ID: hg55160tg5004
HgeneTgene
Gene symbol

ARHGEF10L

ORM1

Gene ID

55160

5004

Gene nameRho guanine nucleotide exchange factor 10 likeorosomucoid 1
SynonymsGrinchGEFAGP-A|AGP1|HEL-S-153w|ORM
Cytomap('ARHGEF10L')('ORM1')

1p36.13

9q32

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 10-like proteinRho guanine nucleotide exchange factor (GEF) 10-likealpha-1-acid glycoprotein 1AGP 1OMD 1epididymis secretory sperm binding protein Li 153w
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000469726, ENST00000167825, 
ENST00000361221, ENST00000375408, 
ENST00000375415, ENST00000434513, 
ENST00000452522, ENST00000375420, 
Fusion gene scores* DoF score12 X 12 X 12=17287 X 6 X 5=210
# samples 177
** MAII scorelog2(17/1728*10)=-3.34549656602577
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGEF10L [Title/Abstract] AND ORM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF10L(17966797)-ORM1(117088571), # samples:1
Anticipated loss of major functional domain due to fusion event.ARHGEF10L-ORM1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGEF10L

GO:0032933

SREBP signaling pathway

16112081

HgeneARHGEF10L

GO:0051496

positive regulation of stress fiber assembly

16112081

TgeneORM1

GO:0032715

negative regulation of interleukin-6 production

23973664

TgeneORM1

GO:0032720

negative regulation of tumor necrosis factor production

23973664

TgeneORM1

GO:0050716

positive regulation of interleukin-1 secretion

8774350

TgeneORM1

GO:0050718

positive regulation of interleukin-1 beta secretion

8774350

TgeneORM1

GO:1904469

positive regulation of tumor necrosis factor secretion

8774350



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4DLBCTCGA-G8-6325ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+


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Fusion Gene ORF analysis for ARHGEF10L-ORM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000469726ENST00000259396ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
3UTR-intronENST00000469726ENST00000477456ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
3UTR-intronENST00000469726ENST00000538816ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
5CDS-intronENST00000167825ENST00000477456ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
5CDS-intronENST00000167825ENST00000538816ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
5CDS-intronENST00000361221ENST00000477456ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
5CDS-intronENST00000361221ENST00000538816ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
5CDS-intronENST00000375408ENST00000477456ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
5CDS-intronENST00000375408ENST00000538816ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
5CDS-intronENST00000375415ENST00000477456ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
5CDS-intronENST00000375415ENST00000538816ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
5CDS-intronENST00000434513ENST00000477456ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
5CDS-intronENST00000434513ENST00000538816ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
5CDS-intronENST00000452522ENST00000477456ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
5CDS-intronENST00000452522ENST00000538816ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
Frame-shiftENST00000167825ENST00000259396ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
Frame-shiftENST00000361221ENST00000259396ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
Frame-shiftENST00000375408ENST00000259396ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
Frame-shiftENST00000375415ENST00000259396ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
Frame-shiftENST00000434513ENST00000259396ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
Frame-shiftENST00000452522ENST00000259396ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
intron-3CDSENST00000375420ENST00000259396ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
intron-intronENST00000375420ENST00000477456ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+
intron-intronENST00000375420ENST00000538816ARHGEF10Lchr1

17966797

+ORM1chr9

117088571

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARHGEF10L-ORM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGEF10Lchr117966797+ORM1chr9117088571+1.66E-050.99998343
ARHGEF10Lchr117966797+ORM1chr9117088571+1.66E-050.99998343


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGEF10L-ORM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:17966797/:117088571)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARHGEF10L-ORM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARHGEF10L-ORM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGEF10L-ORM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGEF10L-ORM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0013221Drug toxicity1CTD_human
TgeneC0022660Kidney Failure, Acute1CTD_human
TgeneC0041755Adverse reaction to drug1CTD_human
TgeneC0085605Liver Failure1CTD_human
TgeneC1565662Acute Kidney Insufficiency1CTD_human
TgeneC2609414Acute kidney injury1CTD_human