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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM33-AASDHPPT (FusionGDB2 ID:HG55161TG60496)

Fusion Gene Summary for TMEM33-AASDHPPT

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM33-AASDHPPT
Fusion gene ID: hg55161tg60496
HgeneTgene
Gene symbol

TMEM33

AASDHPPT

Gene ID

55161

60496

Gene nametransmembrane protein 33aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Synonyms1600019D15Rik|Pom33|SHINC-3|SHINC3AASD-PPT|ACPS|CGI-80|LYS2|LYS5
Cytomap('TMEM33')('AASDHPPT')

4p13

11q22.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 33L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase4'-phosphopantetheinyl transferaseLYS5 orthologalpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferaseholo ACP synthaseholo-[acyl-carrier-protein] synthase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000325094, ENST00000504986, 
ENST00000513702, 
Fusion gene scores* DoF score6 X 6 X 2=723 X 3 X 2=18
# samples 63
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMEM33 [Title/Abstract] AND AASDHPPT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM33(41937544)-AASDHPPT(105948475), # samples:1
Anticipated loss of major functional domain due to fusion event.TMEM33-AASDHPPT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMEM33-AASDHPPT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMEM33

GO:0034976

response to endoplasmic reticulum stress

26268696

HgeneTMEM33

GO:1903371

regulation of endoplasmic reticulum tubular network organization

25612671

HgeneTMEM33

GO:1903896

positive regulation of IRE1-mediated unfolded protein response

26268696

HgeneTMEM33

GO:1903899

positive regulation of PERK-mediated unfolded protein response

26268696


check buttonFusion gene breakpoints across TMEM33 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across AASDHPPT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for TMEM33-AASDHPPT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000504986ENST00000278618TMEM33chr441937544+AASDHPPTchr11105948475+0.0007638640.9992361
ENST00000513702ENST00000278618TMEM33chr441937544+AASDHPPTchr11105948475+0.000734330.9992656
ENST00000325094ENST00000278618TMEM33chr441937544+AASDHPPTchr11105948475+0.0007620060.999238

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Fusion Genomic Features for TMEM33-AASDHPPT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for TMEM33-AASDHPPT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:41937544/chr11:105948475)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAASDHPPTchr4:41937544chr11:105948475ENST0000027861806108_1110310.0RegionCoenzyme A binding
TgeneAASDHPPTchr4:41937544chr11:105948475ENST0000027861806181_1850310.0RegionCoenzyme A binding
TgeneAASDHPPTchr4:41937544chr11:105948475ENST000002786180686_910310.0RegionCoenzyme A binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM33chr4:41937544chr11:105948475ENST00000325094+18122_15515686.0Topological domainLumenal
HgeneTMEM33chr4:41937544chr11:105948475ENST00000325094+18177_24715686.0Topological domainCytoplasmic
HgeneTMEM33chr4:41937544chr11:105948475ENST00000325094+182_3115686.0Topological domainLumenal
HgeneTMEM33chr4:41937544chr11:105948475ENST00000325094+1853_10015686.0Topological domainCytoplasmic
HgeneTMEM33chr4:41937544chr11:105948475ENST00000504986+17122_15515248.0Topological domainLumenal
HgeneTMEM33chr4:41937544chr11:105948475ENST00000504986+17177_24715248.0Topological domainCytoplasmic
HgeneTMEM33chr4:41937544chr11:105948475ENST00000504986+172_3115248.0Topological domainLumenal
HgeneTMEM33chr4:41937544chr11:105948475ENST00000504986+1753_10015248.0Topological domainCytoplasmic
HgeneTMEM33chr4:41937544chr11:105948475ENST00000513702+28122_15515248.0Topological domainLumenal
HgeneTMEM33chr4:41937544chr11:105948475ENST00000513702+28177_24715248.0Topological domainCytoplasmic
HgeneTMEM33chr4:41937544chr11:105948475ENST00000513702+282_3115248.0Topological domainLumenal
HgeneTMEM33chr4:41937544chr11:105948475ENST00000513702+2853_10015248.0Topological domainCytoplasmic
HgeneTMEM33chr4:41937544chr11:105948475ENST00000325094+18101_12115686.0TransmembraneHelical
HgeneTMEM33chr4:41937544chr11:105948475ENST00000325094+18156_17615686.0TransmembraneHelical
HgeneTMEM33chr4:41937544chr11:105948475ENST00000325094+1832_5215686.0TransmembraneHelical
HgeneTMEM33chr4:41937544chr11:105948475ENST00000504986+17101_12115248.0TransmembraneHelical
HgeneTMEM33chr4:41937544chr11:105948475ENST00000504986+17156_17615248.0TransmembraneHelical
HgeneTMEM33chr4:41937544chr11:105948475ENST00000504986+1732_5215248.0TransmembraneHelical
HgeneTMEM33chr4:41937544chr11:105948475ENST00000513702+28101_12115248.0TransmembraneHelical
HgeneTMEM33chr4:41937544chr11:105948475ENST00000513702+28156_17615248.0TransmembraneHelical
HgeneTMEM33chr4:41937544chr11:105948475ENST00000513702+2832_5215248.0TransmembraneHelical


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Fusion Gene Sequence for TMEM33-AASDHPPT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92073_92073_1_TMEM33-AASDHPPT_TMEM33_chr4_41937544_ENST00000325094_AASDHPPT_chr11_105948475_ENST00000278618_length(transcript)=3073nt_BP=378nt
AATAACCTGGAGCCGGCGGCGTAGGTTGGCTCTTTAGGGCTTCACCCCGAAGCTCCACCTTCGCTCCCGTCTTTCTGGAAACACCGCTTT
GATCTCGGCGGTGCGGGACAGGTACCTCCCGGCTGCTGCGGGTGCCCTGGATCCAGTCGGCTGCACCAGGCGAGCGAGACCCTTCCCTGG
TGGAGGCTCAGAGTTCCGGCAGGGTGCATCCGGCCTGTGTGTGGCGCGAGGCAGGGAAGCCGGTACCCGGGTCCTGGCCCCAGCGCTGAC
GTTTTCTCTCCCCTTTCTTCTCTCTTCGCGGTTGCGGCGTCGCAGACGCTAGTGTGAGCCCCCATGGCAGATACGACCCCGAACGGCCCC
CAAGGGGCGGGCGCTGTGCATGGAGGGCGTGCGCTGGGCCTTTTCCTGCGGCACTTGGCTGCCGAGCCGAGCCGAATGGCTGCTGGCAGT
GCGATCGATTCAGCCCGAGGAGAAGGAGCGCATTGGCCAGTTCGTCTTTGCCCGGGACGCTAAGGCAGCCATGGCTGGTCGTCTGATGAT
AAGGAAATTAGTTGCAGAGAAATTGAATATCCCTTGGAATCATATTCGTTTGCAAAGAACTGCAAAAGGAAAACCAGTTCTTGCAAAGGA
CTCATCGAATCCTTACCCGAATTTCAACTTTAACATCTCTCATCAAGGAGACTATGCAGTGCTTGCTGCTGAACCTGAGCTGCAAGTTGG
AATTGATATAATGAAGACTAGTTTTCCAGGTCGTGGTTCAATTCCAGAATTCTTTCATATTATGAAAAGAAAGTTTACCAACAAAGAATG
GGAAACAATCAGAAGCTTTAAGGATGAGTGGACTCAGCTGGATATGTTTTATAGGAATTGGGCACTTAAGGAAAGCTTCATAAAAGCCAT
TGGTGTTGGACTAGGATTTGAATTGCAGCGGCTTGAATTTGATCTATCTCCATTAAACTTGGATATAGGCCAAGTTTATAAAGAAACACG
TTTATTCCTGGATGGAGAGGAAGAAAAAGAATGGGCATTTGAGGAAAGCAAAATAGATGAGCACCATTTTGTTGCAGTTGCTCTTAGGAA
ACCCGATGGATCTAGACATCAGGATGTTCCATCTCAGGATGATTCCAAACCAACCCAGAGGCAATTTACTATTCTCAACTTTAATGATTT
AATGTCATCTGCCGTTCCCATGACACCTGAAGATCCTTCATTTTGGGACTGTTTTTGCTTCACAGAAGAAATTCCAATACGAAATGGTAC
AAAGTCATGATGATTCCCTGAGTAACAAAGGGAAATGAAAACTGTTTGTGATCTTCCGTATTCACTGAAAAATAAATGCTTGTTTAGTAT
CAAATTTTATTTCACGAAAGTTTTTTTAAAGAACAGAAACTTTTCCAATTAAAAAAAAAAAGCAGACTTCTGGTTCAAGATAGCTCACTG
GAATACATGTTTACCTCTTTCTTTCCTAAATTGCATTGAATTGATAGGAAGGATGGCGGAATCTTAAAGTGATACATGCTAACTGTAGAA
AAAAATAGAAAATGCACATAAGCAAAAGGAAACATTTAAATGCTATCTTTCAAAGATAACTACTCTTAAAACCTTGAGTATCTTTTCAGA
CCTTTTTCTTGGCAAATGAATCCATATTGACATATTTGATTTTTTTAAAAACATGGAAACGTACTGTTTTGTAAATTCTTTTTAACTGCA
CATCTACTGTTCATAAATATACCTCTGTAACATAACTTTTTGTGGTTCTAATGTACTCTGTTGTATAGCTAATACAAGTTAGGATGCTTT
TGGCCAGAGGTAACAGTGTCCAAATATAATTGGCCTAAGTAACCTAGGAAATTGTTTGACATAACACAGGGTTCAGGGGTGTCATTAAAG
ACACACTTTTTTTGCCTTGACCTCAGTTGGTTTGTTTTGCCTTAGGCTATTCCACCTCTCGATCACAAGAGCTGCTGCTATAACTTCCAG
TTTTACATCTTTGTAAAATTGTATCTCAAAGGCAGAAAAGGCCATTTCGTCTCTCATTTGTTTTATCCATGAGGAAGATTTTTAACAAAA
GCCTCCAGAAGATTTCCCCTCAGTTTCCATTGACTTAGATCAGGTTACAGAGAAAGGCAATGTCTGACATTTTTGGTCTCTGTTAGAAGT
AGACTCTGTTGAAAAGAAAGAAGCTAAGCTAGGTGTGAAGAATGGAATTGGAAGCCCACTGCCTTCCCATAAGAAAGGTTTACCATAATT
TACTCACTTTTTTCTGTGTTAGACATTTTGATTATCTGCAGTTTATTACTACAAGCAGTGGCAGAGTGAATGTCCTTGTACATTTTGAGT
TACATGCTTAATTATGTCCTTGAGAAAGTTTCTAAAAGTGGAATGATTGGTTTGACTGGTTCATAGGGCTTTAATTATACAATTTACCCC
TCTAATTAGTACTATATGTATGTGACTTCCCTCCCCCTGCCAGAATACTCCTTGGTCAATTGTAGGTATTCTTTTTGGTTTAATTTTTGC
CAATGTAATTAAAAAATGGTATGTCATTTTTAAAATTTGTATTTCTTTCATTACAAATAAGATTGTTATGTCAGTATTGTTATTGGCTTT
TCGTATTCCTCTTAACGTGAACCGTCTGTTCATTGTTTTTACCTGTTTTCGTTTTAGCAAGTAGTACTTAATTTAAAGTGTGAACTTAAT
ATATAAGATGCCAGGACCATCATATTGATGACAAAAATCTATTATGTGGTTGTAGTGCATGTCTTGGAGTTAAACTCTTAAGTATCAAGA
AGTAAAATAATTTCATTGTTTCTGTTACTAACATTAAAAGTGTGCAAATTGTATAAAATTAGGTACTTCGATTAGTAAAAGAAAAAAATT
TGAATGTTTTTTTTTTTTATTTTATTAAGCATGCCCAGTTATGCCAAGCATAGTAAATAAAGGTCAAGTAGCATTTATAATAGAGGAAGT
ATTGTTATCCCTAGCATGAGTGTAATGGTGATATGAAAAACTTTGTCTTGTCATTATAATAATAAAAAAATGAACATTTATTATGGAATT

>92073_92073_1_TMEM33-AASDHPPT_TMEM33_chr4_41937544_ENST00000325094_AASDHPPT_chr11_105948475_ENST00000278618_length(amino acids)=298AA_BP=2
MCMEGVRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDAKAAMAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVLAKDSSNP
YPNFNFNISHQGDYAVLAAEPELQVGIDIMKTSFPGRGSIPEFFHIMKRKFTNKEWETIRSFKDEWTQLDMFYRNWALKESFIKAIGVGL
GFELQRLEFDLSPLNLDIGQVYKETRLFLDGEEEKEWAFEESKIDEHHFVAVALRKPDGSRHQDVPSQDDSKPTQRQFTILNFNDLMSSA

--------------------------------------------------------------
>92073_92073_2_TMEM33-AASDHPPT_TMEM33_chr4_41937544_ENST00000504986_AASDHPPT_chr11_105948475_ENST00000278618_length(transcript)=3105nt_BP=410nt
ACGGAAATGAAAGGAGCACTTCCGGGTTCGGCAATAACCTGGAGCCGGCGGCGTAGGTTGGCTCTTTAGGGCTTCACCCCGAAGCTCCAC
CTTCGCTCCCGTCTTTCTGGAAACACCGCTTTGATCTCGGCGGTGCGGGACAGGTACCTCCCGGCTGCTGCGGGTGCCCTGGATCCAGTC
GGCTGCACCAGGCGAGCGAGACCCTTCCCTGGTGGAGGCTCAGAGTTCCGGCAGGGTGCATCCGGCCTGTGTGTGGCGCGAGGCAGGGAA
GCCGGTACCCGGGTCCTGGCCCCAGCGCTGACGTTTTCTCTCCCCTTTCTTCTCTCTTCGCGGTTGCGGCGTCGCAGACGCTAGTGTGAG
CCCCCATGGCAGATACGACCCCGAACGGCCCCCAAGGGGCGGGCGCTGTGCATGGAGGGCGTGCGCTGGGCCTTTTCCTGCGGCACTTGG
CTGCCGAGCCGAGCCGAATGGCTGCTGGCAGTGCGATCGATTCAGCCCGAGGAGAAGGAGCGCATTGGCCAGTTCGTCTTTGCCCGGGAC
GCTAAGGCAGCCATGGCTGGTCGTCTGATGATAAGGAAATTAGTTGCAGAGAAATTGAATATCCCTTGGAATCATATTCGTTTGCAAAGA
ACTGCAAAAGGAAAACCAGTTCTTGCAAAGGACTCATCGAATCCTTACCCGAATTTCAACTTTAACATCTCTCATCAAGGAGACTATGCA
GTGCTTGCTGCTGAACCTGAGCTGCAAGTTGGAATTGATATAATGAAGACTAGTTTTCCAGGTCGTGGTTCAATTCCAGAATTCTTTCAT
ATTATGAAAAGAAAGTTTACCAACAAAGAATGGGAAACAATCAGAAGCTTTAAGGATGAGTGGACTCAGCTGGATATGTTTTATAGGAAT
TGGGCACTTAAGGAAAGCTTCATAAAAGCCATTGGTGTTGGACTAGGATTTGAATTGCAGCGGCTTGAATTTGATCTATCTCCATTAAAC
TTGGATATAGGCCAAGTTTATAAAGAAACACGTTTATTCCTGGATGGAGAGGAAGAAAAAGAATGGGCATTTGAGGAAAGCAAAATAGAT
GAGCACCATTTTGTTGCAGTTGCTCTTAGGAAACCCGATGGATCTAGACATCAGGATGTTCCATCTCAGGATGATTCCAAACCAACCCAG
AGGCAATTTACTATTCTCAACTTTAATGATTTAATGTCATCTGCCGTTCCCATGACACCTGAAGATCCTTCATTTTGGGACTGTTTTTGC
TTCACAGAAGAAATTCCAATACGAAATGGTACAAAGTCATGATGATTCCCTGAGTAACAAAGGGAAATGAAAACTGTTTGTGATCTTCCG
TATTCACTGAAAAATAAATGCTTGTTTAGTATCAAATTTTATTTCACGAAAGTTTTTTTAAAGAACAGAAACTTTTCCAATTAAAAAAAA
AAAGCAGACTTCTGGTTCAAGATAGCTCACTGGAATACATGTTTACCTCTTTCTTTCCTAAATTGCATTGAATTGATAGGAAGGATGGCG
GAATCTTAAAGTGATACATGCTAACTGTAGAAAAAAATAGAAAATGCACATAAGCAAAAGGAAACATTTAAATGCTATCTTTCAAAGATA
ACTACTCTTAAAACCTTGAGTATCTTTTCAGACCTTTTTCTTGGCAAATGAATCCATATTGACATATTTGATTTTTTTAAAAACATGGAA
ACGTACTGTTTTGTAAATTCTTTTTAACTGCACATCTACTGTTCATAAATATACCTCTGTAACATAACTTTTTGTGGTTCTAATGTACTC
TGTTGTATAGCTAATACAAGTTAGGATGCTTTTGGCCAGAGGTAACAGTGTCCAAATATAATTGGCCTAAGTAACCTAGGAAATTGTTTG
ACATAACACAGGGTTCAGGGGTGTCATTAAAGACACACTTTTTTTGCCTTGACCTCAGTTGGTTTGTTTTGCCTTAGGCTATTCCACCTC
TCGATCACAAGAGCTGCTGCTATAACTTCCAGTTTTACATCTTTGTAAAATTGTATCTCAAAGGCAGAAAAGGCCATTTCGTCTCTCATT
TGTTTTATCCATGAGGAAGATTTTTAACAAAAGCCTCCAGAAGATTTCCCCTCAGTTTCCATTGACTTAGATCAGGTTACAGAGAAAGGC
AATGTCTGACATTTTTGGTCTCTGTTAGAAGTAGACTCTGTTGAAAAGAAAGAAGCTAAGCTAGGTGTGAAGAATGGAATTGGAAGCCCA
CTGCCTTCCCATAAGAAAGGTTTACCATAATTTACTCACTTTTTTCTGTGTTAGACATTTTGATTATCTGCAGTTTATTACTACAAGCAG
TGGCAGAGTGAATGTCCTTGTACATTTTGAGTTACATGCTTAATTATGTCCTTGAGAAAGTTTCTAAAAGTGGAATGATTGGTTTGACTG
GTTCATAGGGCTTTAATTATACAATTTACCCCTCTAATTAGTACTATATGTATGTGACTTCCCTCCCCCTGCCAGAATACTCCTTGGTCA
ATTGTAGGTATTCTTTTTGGTTTAATTTTTGCCAATGTAATTAAAAAATGGTATGTCATTTTTAAAATTTGTATTTCTTTCATTACAAAT
AAGATTGTTATGTCAGTATTGTTATTGGCTTTTCGTATTCCTCTTAACGTGAACCGTCTGTTCATTGTTTTTACCTGTTTTCGTTTTAGC
AAGTAGTACTTAATTTAAAGTGTGAACTTAATATATAAGATGCCAGGACCATCATATTGATGACAAAAATCTATTATGTGGTTGTAGTGC
ATGTCTTGGAGTTAAACTCTTAAGTATCAAGAAGTAAAATAATTTCATTGTTTCTGTTACTAACATTAAAAGTGTGCAAATTGTATAAAA
TTAGGTACTTCGATTAGTAAAAGAAAAAAATTTGAATGTTTTTTTTTTTTATTTTATTAAGCATGCCCAGTTATGCCAAGCATAGTAAAT
AAAGGTCAAGTAGCATTTATAATAGAGGAAGTATTGTTATCCCTAGCATGAGTGTAATGGTGATATGAAAAACTTTGTCTTGTCATTATA

>92073_92073_2_TMEM33-AASDHPPT_TMEM33_chr4_41937544_ENST00000504986_AASDHPPT_chr11_105948475_ENST00000278618_length(amino acids)=298AA_BP=2
MCMEGVRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDAKAAMAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVLAKDSSNP
YPNFNFNISHQGDYAVLAAEPELQVGIDIMKTSFPGRGSIPEFFHIMKRKFTNKEWETIRSFKDEWTQLDMFYRNWALKESFIKAIGVGL
GFELQRLEFDLSPLNLDIGQVYKETRLFLDGEEEKEWAFEESKIDEHHFVAVALRKPDGSRHQDVPSQDDSKPTQRQFTILNFNDLMSSA

--------------------------------------------------------------
>92073_92073_3_TMEM33-AASDHPPT_TMEM33_chr4_41937544_ENST00000513702_AASDHPPT_chr11_105948475_ENST00000278618_length(transcript)=2892nt_BP=197nt
AAAGGAGCACTTCCGGGTTCGGCAATAACCTGGAGCCGGCGGCGTAGGTTGGCTCTTTAGGGCTTCACCCCGAAGCTCCACCTTCGCTCC
CGTCTTTCTGGAAACACCGCTTTGATCTCGGCGGTGCGGGACAGACGCTAGTGTGAGCCCCCATGGCAGATACGACCCCGAACGGCCCCC
AAGGGGCGGGCGCTGTGCATGGAGGGCGTGCGCTGGGCCTTTTCCTGCGGCACTTGGCTGCCGAGCCGAGCCGAATGGCTGCTGGCAGTG
CGATCGATTCAGCCCGAGGAGAAGGAGCGCATTGGCCAGTTCGTCTTTGCCCGGGACGCTAAGGCAGCCATGGCTGGTCGTCTGATGATA
AGGAAATTAGTTGCAGAGAAATTGAATATCCCTTGGAATCATATTCGTTTGCAAAGAACTGCAAAAGGAAAACCAGTTCTTGCAAAGGAC
TCATCGAATCCTTACCCGAATTTCAACTTTAACATCTCTCATCAAGGAGACTATGCAGTGCTTGCTGCTGAACCTGAGCTGCAAGTTGGA
ATTGATATAATGAAGACTAGTTTTCCAGGTCGTGGTTCAATTCCAGAATTCTTTCATATTATGAAAAGAAAGTTTACCAACAAAGAATGG
GAAACAATCAGAAGCTTTAAGGATGAGTGGACTCAGCTGGATATGTTTTATAGGAATTGGGCACTTAAGGAAAGCTTCATAAAAGCCATT
GGTGTTGGACTAGGATTTGAATTGCAGCGGCTTGAATTTGATCTATCTCCATTAAACTTGGATATAGGCCAAGTTTATAAAGAAACACGT
TTATTCCTGGATGGAGAGGAAGAAAAAGAATGGGCATTTGAGGAAAGCAAAATAGATGAGCACCATTTTGTTGCAGTTGCTCTTAGGAAA
CCCGATGGATCTAGACATCAGGATGTTCCATCTCAGGATGATTCCAAACCAACCCAGAGGCAATTTACTATTCTCAACTTTAATGATTTA
ATGTCATCTGCCGTTCCCATGACACCTGAAGATCCTTCATTTTGGGACTGTTTTTGCTTCACAGAAGAAATTCCAATACGAAATGGTACA
AAGTCATGATGATTCCCTGAGTAACAAAGGGAAATGAAAACTGTTTGTGATCTTCCGTATTCACTGAAAAATAAATGCTTGTTTAGTATC
AAATTTTATTTCACGAAAGTTTTTTTAAAGAACAGAAACTTTTCCAATTAAAAAAAAAAAGCAGACTTCTGGTTCAAGATAGCTCACTGG
AATACATGTTTACCTCTTTCTTTCCTAAATTGCATTGAATTGATAGGAAGGATGGCGGAATCTTAAAGTGATACATGCTAACTGTAGAAA
AAAATAGAAAATGCACATAAGCAAAAGGAAACATTTAAATGCTATCTTTCAAAGATAACTACTCTTAAAACCTTGAGTATCTTTTCAGAC
CTTTTTCTTGGCAAATGAATCCATATTGACATATTTGATTTTTTTAAAAACATGGAAACGTACTGTTTTGTAAATTCTTTTTAACTGCAC
ATCTACTGTTCATAAATATACCTCTGTAACATAACTTTTTGTGGTTCTAATGTACTCTGTTGTATAGCTAATACAAGTTAGGATGCTTTT
GGCCAGAGGTAACAGTGTCCAAATATAATTGGCCTAAGTAACCTAGGAAATTGTTTGACATAACACAGGGTTCAGGGGTGTCATTAAAGA
CACACTTTTTTTGCCTTGACCTCAGTTGGTTTGTTTTGCCTTAGGCTATTCCACCTCTCGATCACAAGAGCTGCTGCTATAACTTCCAGT
TTTACATCTTTGTAAAATTGTATCTCAAAGGCAGAAAAGGCCATTTCGTCTCTCATTTGTTTTATCCATGAGGAAGATTTTTAACAAAAG
CCTCCAGAAGATTTCCCCTCAGTTTCCATTGACTTAGATCAGGTTACAGAGAAAGGCAATGTCTGACATTTTTGGTCTCTGTTAGAAGTA
GACTCTGTTGAAAAGAAAGAAGCTAAGCTAGGTGTGAAGAATGGAATTGGAAGCCCACTGCCTTCCCATAAGAAAGGTTTACCATAATTT
ACTCACTTTTTTCTGTGTTAGACATTTTGATTATCTGCAGTTTATTACTACAAGCAGTGGCAGAGTGAATGTCCTTGTACATTTTGAGTT
ACATGCTTAATTATGTCCTTGAGAAAGTTTCTAAAAGTGGAATGATTGGTTTGACTGGTTCATAGGGCTTTAATTATACAATTTACCCCT
CTAATTAGTACTATATGTATGTGACTTCCCTCCCCCTGCCAGAATACTCCTTGGTCAATTGTAGGTATTCTTTTTGGTTTAATTTTTGCC
AATGTAATTAAAAAATGGTATGTCATTTTTAAAATTTGTATTTCTTTCATTACAAATAAGATTGTTATGTCAGTATTGTTATTGGCTTTT
CGTATTCCTCTTAACGTGAACCGTCTGTTCATTGTTTTTACCTGTTTTCGTTTTAGCAAGTAGTACTTAATTTAAAGTGTGAACTTAATA
TATAAGATGCCAGGACCATCATATTGATGACAAAAATCTATTATGTGGTTGTAGTGCATGTCTTGGAGTTAAACTCTTAAGTATCAAGAA
GTAAAATAATTTCATTGTTTCTGTTACTAACATTAAAAGTGTGCAAATTGTATAAAATTAGGTACTTCGATTAGTAAAAGAAAAAAATTT
GAATGTTTTTTTTTTTTATTTTATTAAGCATGCCCAGTTATGCCAAGCATAGTAAATAAAGGTCAAGTAGCATTTATAATAGAGGAAGTA
TTGTTATCCCTAGCATGAGTGTAATGGTGATATGAAAAACTTTGTCTTGTCATTATAATAATAAAAAAATGAACATTTATTATGGAATTT

>92073_92073_3_TMEM33-AASDHPPT_TMEM33_chr4_41937544_ENST00000513702_AASDHPPT_chr11_105948475_ENST00000278618_length(amino acids)=298AA_BP=2
MCMEGVRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDAKAAMAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVLAKDSSNP
YPNFNFNISHQGDYAVLAAEPELQVGIDIMKTSFPGRGSIPEFFHIMKRKFTNKEWETIRSFKDEWTQLDMFYRNWALKESFIKAIGVGL
GFELQRLEFDLSPLNLDIGQVYKETRLFLDGEEEKEWAFEESKIDEHHFVAVALRKPDGSRHQDVPSQDDSKPTQRQFTILNFNDLMSSA

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Fusion Gene PPI Analysis for TMEM33-AASDHPPT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM33-AASDHPPT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM33-AASDHPPT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource