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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APPL2-CIT (FusionGDB2 ID:HG55198TG11113)

Fusion Gene Summary for APPL2-CIT

check button Fusion gene summary
Fusion gene informationFusion gene name: APPL2-CIT
Fusion gene ID: hg55198tg11113
HgeneTgene
Gene symbol

APPL2

CIT

Gene ID

55198

11113

Gene nameadaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2citron rho-interacting serine/threonine kinase
SynonymsDIP13BCITK|CRIK|MCPH17|STK21
Cytomap('APPL2')('CIT')

12q23.3

12q24.23

Type of geneprotein-codingprotein-coding
DescriptionDCC-interacting protein 13-betaDIP13 betaadapter protein containing PH domain, PTB domain and leucine zipper motif 2adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2citron Rho-interacting kinasecitron (rho-interacting, serine/threonine kinase 21)serine/threonine kinase 21serine/threonine-protein kinase 21
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000258530, ENST00000551662, 
ENST00000539978, ENST00000546731, 
ENST00000549573, 
Fusion gene scores* DoF score9 X 10 X 5=4504 X 4 X 4=64
# samples 105
** MAII scorelog2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APPL2 [Title/Abstract] AND CIT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPPL2(105629737)-CIT(120198859), # samples:3
Anticipated loss of major functional domain due to fusion event.APPL2-CIT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APPL2-CIT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APPL2-CIT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APPL2-CIT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPPL2

GO:0006606

protein import into nucleus

26583432

HgeneAPPL2

GO:0051289

protein homotetramerization

23055524

HgeneAPPL2

GO:2000045

regulation of G1/S transition of mitotic cell cycle

15016378


check buttonFusion gene breakpoints across APPL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CIT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-34-5232-01AAPPL2chr12

105629737

-CITchr12

120198859

-
ChimerDB4LUSCTCGA-34-5232APPL2chr12

105629736

-CITchr12

120198859

-
ChimerDB4LUSCTCGA-34-5232APPL2chr12

105629737

-CITchr12

120198859

-


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Fusion Gene ORF analysis for APPL2-CIT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000258530ENST00000537607APPL2chr12

105629737

-CITchr12

120198859

-
5CDS-5UTRENST00000258530ENST00000537607APPL2chr12

105629736

-CITchr12

120198859

-
5CDS-5UTRENST00000551662ENST00000537607APPL2chr12

105629737

-CITchr12

120198859

-
5CDS-5UTRENST00000551662ENST00000537607APPL2chr12

105629736

-CITchr12

120198859

-
In-frameENST00000258530ENST00000261833APPL2chr12

105629737

-CITchr12

120198859

-
In-frameENST00000258530ENST00000261833APPL2chr12

105629736

-CITchr12

120198859

-
In-frameENST00000258530ENST00000392521APPL2chr12

105629737

-CITchr12

120198859

-
In-frameENST00000258530ENST00000392521APPL2chr12

105629736

-CITchr12

120198859

-
In-frameENST00000551662ENST00000261833APPL2chr12

105629737

-CITchr12

120198859

-
In-frameENST00000551662ENST00000261833APPL2chr12

105629736

-CITchr12

120198859

-
In-frameENST00000551662ENST00000392521APPL2chr12

105629737

-CITchr12

120198859

-
In-frameENST00000551662ENST00000392521APPL2chr12

105629736

-CITchr12

120198859

-
intron-3CDSENST00000539978ENST00000261833APPL2chr12

105629737

-CITchr12

120198859

-
intron-3CDSENST00000539978ENST00000261833APPL2chr12

105629736

-CITchr12

120198859

-
intron-3CDSENST00000539978ENST00000392521APPL2chr12

105629737

-CITchr12

120198859

-
intron-3CDSENST00000539978ENST00000392521APPL2chr12

105629736

-CITchr12

120198859

-
intron-3CDSENST00000546731ENST00000261833APPL2chr12

105629737

-CITchr12

120198859

-
intron-3CDSENST00000546731ENST00000261833APPL2chr12

105629736

-CITchr12

120198859

-
intron-3CDSENST00000546731ENST00000392521APPL2chr12

105629737

-CITchr12

120198859

-
intron-3CDSENST00000546731ENST00000392521APPL2chr12

105629736

-CITchr12

120198859

-
intron-3CDSENST00000549573ENST00000261833APPL2chr12

105629737

-CITchr12

120198859

-
intron-3CDSENST00000549573ENST00000261833APPL2chr12

105629736

-CITchr12

120198859

-
intron-3CDSENST00000549573ENST00000392521APPL2chr12

105629737

-CITchr12

120198859

-
intron-3CDSENST00000549573ENST00000392521APPL2chr12

105629736

-CITchr12

120198859

-
intron-5UTRENST00000539978ENST00000537607APPL2chr12

105629737

-CITchr12

120198859

-
intron-5UTRENST00000539978ENST00000537607APPL2chr12

105629736

-CITchr12

120198859

-
intron-5UTRENST00000546731ENST00000537607APPL2chr12

105629737

-CITchr12

120198859

-
intron-5UTRENST00000546731ENST00000537607APPL2chr12

105629736

-CITchr12

120198859

-
intron-5UTRENST00000549573ENST00000537607APPL2chr12

105629737

-CITchr12

120198859

-
intron-5UTRENST00000549573ENST00000537607APPL2chr12

105629736

-CITchr12

120198859

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000258530APPL2chr12105629737-ENST00000392521CITchr12120198859-66282807941851368
ENST00000258530APPL2chr12105629737-ENST00000261833CITchr12120198859-66272807941851368
ENST00000551662APPL2chr12105629737-ENST00000392521CITchr12120198859-64731252340301335
ENST00000551662APPL2chr12105629737-ENST00000261833CITchr12120198859-64721252340301335
ENST00000258530APPL2chr12105629736-ENST00000392521CITchr12120198859-66282807941851368
ENST00000258530APPL2chr12105629736-ENST00000261833CITchr12120198859-66272807941851368
ENST00000551662APPL2chr12105629736-ENST00000392521CITchr12120198859-64731252340301335
ENST00000551662APPL2chr12105629736-ENST00000261833CITchr12120198859-64721252340301335

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000258530ENST00000392521APPL2chr12105629737-CITchr12120198859-0.0026104730.9973895
ENST00000258530ENST00000261833APPL2chr12105629737-CITchr12120198859-0.0026185730.9973814
ENST00000551662ENST00000392521APPL2chr12105629737-CITchr12120198859-0.0021592670.99784076
ENST00000551662ENST00000261833APPL2chr12105629737-CITchr12120198859-0.0021661640.9978338
ENST00000258530ENST00000392521APPL2chr12105629736-CITchr12120198859-0.0026104730.9973895
ENST00000258530ENST00000261833APPL2chr12105629736-CITchr12120198859-0.0026185730.9973814
ENST00000551662ENST00000392521APPL2chr12105629736-CITchr12120198859-0.0021592670.99784076
ENST00000551662ENST00000261833APPL2chr12105629736-CITchr12120198859-0.0021661640.9978338

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Fusion Genomic Features for APPL2-CIT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for APPL2-CIT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:105629737/chr12:120198859)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCITchr12:105629736chr12:120198859ENST0000026183317471443_15637262028.0DomainPH
TgeneCITchr12:105629736chr12:120198859ENST0000026183317471591_18817262028.0DomainCNH
TgeneCITchr12:105629736chr12:120198859ENST0000039252118481443_15637682070.0DomainPH
TgeneCITchr12:105629736chr12:120198859ENST0000039252118481591_18817682070.0DomainCNH
TgeneCITchr12:105629737chr12:120198859ENST0000026183317471443_15637262028.0DomainPH
TgeneCITchr12:105629737chr12:120198859ENST0000026183317471591_18817262028.0DomainCNH
TgeneCITchr12:105629737chr12:120198859ENST0000039252118481443_15637682070.0DomainPH
TgeneCITchr12:105629737chr12:120198859ENST0000039252118481591_18817682070.0DomainCNH
TgeneCITchr12:105629736chr12:120198859ENST0000026183317471953_19587262028.0MotifSH3-binding
TgeneCITchr12:105629736chr12:120198859ENST0000039252118481953_19587682070.0MotifSH3-binding
TgeneCITchr12:105629737chr12:120198859ENST0000026183317471953_19587262028.0MotifSH3-binding
TgeneCITchr12:105629737chr12:120198859ENST0000039252118481953_19587682070.0MotifSH3-binding
TgeneCITchr12:105629736chr12:120198859ENST0000026183317471362_14117262028.0Zinc fingerPhorbol-ester/DAG-type
TgeneCITchr12:105629736chr12:120198859ENST0000039252118481362_14117682070.0Zinc fingerPhorbol-ester/DAG-type
TgeneCITchr12:105629737chr12:120198859ENST0000026183317471362_14117262028.0Zinc fingerPhorbol-ester/DAG-type
TgeneCITchr12:105629737chr12:120198859ENST0000039252118481362_14117682070.0Zinc fingerPhorbol-ester/DAG-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPPL2chr12:105629736chr12:120198859ENST00000258530-121277_37518665.0DomainPH
HgeneAPPL2chr12:105629736chr12:120198859ENST00000258530-1213_26818665.0DomainBAR
HgeneAPPL2chr12:105629736chr12:120198859ENST00000258530-121488_63718665.0DomainPID
HgeneAPPL2chr12:105629736chr12:120198859ENST00000539978-121277_3750622.0DomainPH
HgeneAPPL2chr12:105629736chr12:120198859ENST00000539978-1213_2680622.0DomainBAR
HgeneAPPL2chr12:105629736chr12:120198859ENST00000539978-121488_6370622.0DomainPID
HgeneAPPL2chr12:105629736chr12:120198859ENST00000551662-121277_37518671.0DomainPH
HgeneAPPL2chr12:105629736chr12:120198859ENST00000551662-1213_26818671.0DomainBAR
HgeneAPPL2chr12:105629736chr12:120198859ENST00000551662-121488_63718671.0DomainPID
HgeneAPPL2chr12:105629737chr12:120198859ENST00000258530-121277_37518665.0DomainPH
HgeneAPPL2chr12:105629737chr12:120198859ENST00000258530-1213_26818665.0DomainBAR
HgeneAPPL2chr12:105629737chr12:120198859ENST00000258530-121488_63718665.0DomainPID
HgeneAPPL2chr12:105629737chr12:120198859ENST00000539978-121277_3750622.0DomainPH
HgeneAPPL2chr12:105629737chr12:120198859ENST00000539978-1213_2680622.0DomainBAR
HgeneAPPL2chr12:105629737chr12:120198859ENST00000539978-121488_6370622.0DomainPID
HgeneAPPL2chr12:105629737chr12:120198859ENST00000551662-121277_37518671.0DomainPH
HgeneAPPL2chr12:105629737chr12:120198859ENST00000551662-1213_26818671.0DomainBAR
HgeneAPPL2chr12:105629737chr12:120198859ENST00000551662-121488_63718671.0DomainPID
HgeneAPPL2chr12:105629736chr12:120198859ENST00000258530-1211_42818665.0RegionRequired for RAB5A binding
HgeneAPPL2chr12:105629736chr12:120198859ENST00000539978-1211_4280622.0RegionRequired for RAB5A binding
HgeneAPPL2chr12:105629736chr12:120198859ENST00000551662-1211_42818671.0RegionRequired for RAB5A binding
HgeneAPPL2chr12:105629737chr12:120198859ENST00000258530-1211_42818665.0RegionRequired for RAB5A binding
HgeneAPPL2chr12:105629737chr12:120198859ENST00000539978-1211_4280622.0RegionRequired for RAB5A binding
HgeneAPPL2chr12:105629737chr12:120198859ENST00000551662-1211_42818671.0RegionRequired for RAB5A binding
TgeneCITchr12:105629736chr12:120198859ENST000002618331747453_12977262028.0Coiled coilOntology_term=ECO:0000255
TgeneCITchr12:105629736chr12:120198859ENST000003925211848453_12977682070.0Coiled coilOntology_term=ECO:0000255
TgeneCITchr12:105629737chr12:120198859ENST000002618331747453_12977262028.0Coiled coilOntology_term=ECO:0000255
TgeneCITchr12:105629737chr12:120198859ENST000003925211848453_12977682070.0Coiled coilOntology_term=ECO:0000255
TgeneCITchr12:105629736chr12:120198859ENST000002618331747361_4317262028.0DomainAGC-kinase C-terminal
TgeneCITchr12:105629736chr12:120198859ENST00000261833174797_3607262028.0DomainProtein kinase
TgeneCITchr12:105629736chr12:120198859ENST000003925211848361_4317682070.0DomainAGC-kinase C-terminal
TgeneCITchr12:105629736chr12:120198859ENST00000392521184897_3607682070.0DomainProtein kinase
TgeneCITchr12:105629737chr12:120198859ENST000002618331747361_4317262028.0DomainAGC-kinase C-terminal
TgeneCITchr12:105629737chr12:120198859ENST00000261833174797_3607262028.0DomainProtein kinase
TgeneCITchr12:105629737chr12:120198859ENST000003925211848361_4317682070.0DomainAGC-kinase C-terminal
TgeneCITchr12:105629737chr12:120198859ENST00000392521184897_3607682070.0DomainProtein kinase
TgeneCITchr12:105629736chr12:120198859ENST000002618331747103_1117262028.0Nucleotide bindingATP
TgeneCITchr12:105629736chr12:120198859ENST000003925211848103_1117682070.0Nucleotide bindingATP
TgeneCITchr12:105629737chr12:120198859ENST000002618331747103_1117262028.0Nucleotide bindingATP
TgeneCITchr12:105629737chr12:120198859ENST000003925211848103_1117682070.0Nucleotide bindingATP


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Fusion Gene Sequence for APPL2-CIT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5685_5685_1_APPL2-CIT_APPL2_chr12_105629736_ENST00000258530_CIT_chr12_120198859_ENST00000261833_length(transcript)=6627nt_BP=280nt
TTTCCCTGCCGGGCGCGCCACACTTCCTGTTGATCCGGCTCGGCCGGGGGCTGGGCCGGCGGGCAGGCGGCGGCGGCCACTGGCCAGGCG
TGGACGCGCGCGGGGCCGCCGCGGGCACGGAGTGGCCGCCGCGTCGCCTGAGCCCAGAGCCGGGGAGTGCTCTCGGCCGCCGCGTCTCCT
GCCCTCTGTCCTTCCAACCCAGCCCTCGGCTGAGCCGCGCCGCACCATGCCCGCCGTGGACAAGCTCCTGCTAGAGGAGGCGTTGCAGGA
CAGCCCCCAGGTGTTGGACAATCAGATAAAGAAAGACCTGGCTGACAAGGAGACACTGGAGAACATGATGCAGAGACACGAGGAGGAGGC
CCATGAGAAGGGCAAAATTCTCAGCGAACAGAAGGCGATGATCAATGCTATGGATTCCAAGATCAGATCCCTGGAACAGAGGATTGTGGA
ACTGTCTGAAGCCAATAAACTTGCAGCAAATAGCAGTCTTTTTACCCAAAGGAACATGAAGGCCCAAGAAGAGATGATTTCTGAACTCAG
GCAACAGAAATTTTACCTGGAGACACAGGCTGGGAAGTTGGAGGCCCAGAACCGAAAACTGGAGGAGCAGCTGGAGAAGATCAGCCACCA
AGACCACAGTGACAAGAATCGGCTGCTGGAACTGGAGACAAGATTGCGGGAGGTCAGTCTAGAGCACGAGGAGCAGAAACTGGAGCTCAA
GCGCCAGCTCACAGAGCTACAGCTCTCCCTGCAGGAGCGCGAGTCACAGTTGACAGCCCTGCAGGCTGCACGGGCGGCCCTGGAGAGCCA
GCTTCGCCAGGCGAAGACAGAGCTGGAAGAGACCACAGCAGAAGCTGAAGAGGAGATCCAGGCACTCACGGCACATAGAGATGAAATCCA
GCGCAAATTTGATGCTCTTCGTAACAGCTGTACTGTAATCACAGACCTGGAGGAGCAGCTAAACCAGCTGACCGAGGACAACGCTGAACT
CAACAACCAAAACTTCTACTTGTCCAAACAACTCGATGAGGCTTCTGGCGCCAACGACGAGATTGTACAACTGCGAAGTGAAGTGGACCA
TCTCCGCCGGGAGATCACGGAACGAGAGATGCAGCTTACCAGCCAGAAGCAAACGATGGAGGCTCTGAAGACCACGTGCACCATGCTGGA
GGAACAGGTCATGGATTTGGAGGCCCTAAACGATGAGCTGCTAGAAAAAGAGCGGCAGTGGGAGGCCTGGAGGAGCGTCCTGGGTGATGA
GAAATCCCAGTTTGAGTGTCGGGTTCGAGAGCTGCAGAGAATGCTGGACACCGAGAAACAGAGCAGGGCGAGAGCCGATCAGCGGATCAC
CGAGTCTCGCCAGGTGGTGGAGCTGGCAGTGAAGGAGCACAAGGCTGAGATTCTCGCTCTGCAGCAGGCTCTCAAAGAGCAGAAGCTGAA
GGCCGAGAGCCTCTCTGACAAGCTCAATGACCTGGAGAAGAAGCATGCTATGCTTGAAATGAATGCCCGAAGCTTACAGCAGAAGCTGGA
GACTGAACGAGAGCTCAAACAGAGGCTTCTGGAAGAGCAAGCCAAATTACAGCAGCAGATGGACCTGCAGAAAAATCACATTTTCCGTCT
GACTCAAGGACTGCAAGAAGCTCTAGATCGGGCTGATCTACTGAAGACAGAAAGAAGTGACTTGGAGTATCAGCTGGAAAACATTCAGGT
TCTCTATTCTCATGAAAAGGTGAAAATGGAAGGCACTATTTCTCAACAAACCAAACTCATTGATTTTCTGCAAGCCAAAATGGACCAACC
TGCTAAAAAGAAAAAGGGTTTATTTAGTCGACGGAAAGAGGACCCTGCTTTACCCACACAGGTTCCTCTGCAGTACAATGAGCTGAAGCT
GGCCCTGGAGAAGGAGAAAGCTCGCTGTGCAGAGCTAGAGGAAGCCCTTCAGAAGACCCGCATCGAGCTCCGGTCCGCCCGGGAGGAAGC
TGCCCACCGCAAAGCAACGGACCACCCACACCCATCCACGCCAGCCACCGCGAGGCAGCAGATCGCCATGTCCGCCATCGTGCGGTCGCC
AGAGCACCAGCCCAGTGCCATGAGCCTGCTGGCCCCGCCATCCAGCCGCAGAAAGGAGTCTTCAACTCCAGAGGAATTTAGTCGGCGTCT
TAAGGAACGCATGCACCACAATATTCCTCACCGATTCAACGTAGGACTGAACATGCGAGCCACAAAGTGTGCTGTGTGTCTGGATACCGT
GCACTTTGGACGCCAGGCATCCAAATGTCTCGAATGTCAGGTGATGTGTCACCCCAAGTGCTCCACGTGCTTGCCAGCCACCTGCGGCTT
GCCTGCTGAATATGCCACACACTTCACCGAGGCCTTCTGCCGTGACAAAATGAACTCCCCAGGTCTCCAGACCAAGGAGCCCAGCAGCAG
CTTGCACCTGGAAGGGTGGATGAAGGTGCCCAGGAATAACAAACGAGGACAGCAAGGCTGGGACAGGAAGTACATTGTCCTGGAGGGATC
AAAAGTCCTCATTTATGACAATGAAGCCAGAGAAGCTGGACAGAGGCCGGTGGAAGAATTTGAGCTGTGCCTTCCCGACGGGGATGTATC
TATTCATGGTGCCGTTGGTGCTTCCGAACTCGCAAATACAGCCAAAGCAGATGTCCCATACATACTGAAGATGGAATCTCACCCGCACAC
CACCTGCTGGCCCGGGAGAACCCTCTACTTGCTAGCTCCCAGCTTCCCTGACAAACAGCGCTGGGTCACCGCCTTAGAATCAGTTGTCGC
AGGTGGGAGAGTTTCTAGGGAAAAAGCAGAAGCTGATGCTAAACTGCTTGGAAACTCCCTGCTGAAACTGGAAGGTGATGACCGTCTAGA
CATGAACTGCACGCTGCCCTTCAGTGACCAGGTGGTGTTGGTGGGCACCGAGGAAGGGCTCTACGCCCTGAATGTCTTGAAAAACTCCCT
AACCCATGTCCCAGGAATTGGAGCAGTCTTCCAAATTTATATTATCAAGGACCTGGAGAAGCTACTCATGATAGCAGGAGAAGAGCGGGC
ACTGTGTCTTGTGGACGTGAAGAAAGTGAAACAGTCCCTGGCCCAGTCCCACCTGCCTGCCCAGCCCGACATCTCACCCAACATTTTTGA
AGCTGTCAAGGGCTGCCACTTGTTTGGGGCAGGCAAGATTGAGAACGGGCTCTGCATCTGTGCAGCCATGCCCAGCAAAGTCGTCATTCT
CCGCTACAACGAAAACCTCAGCAAATACTGCATCCGGAAAGAGATAGAGACCTCAGAGCCCTGCAGCTGTATCCACTTCACCAATTACAG
TATCCTCATTGGAACCAATAAATTCTACGAAATCGACATGAAGCAGTACACGCTCGAGGAATTCCTGGATAAGAATGACCATTCCTTGGC
ACCTGCTGTGTTTGCCGCCTCTTCCAACAGCTTCCCTGTCTCAATCGTGCAGGTGAACAGCGCAGGGCAGCGAGAGGAGTACTTGCTGTG
TTTCCACGAATTTGGAGTGTTCGTGGATTCTTACGGAAGACGTAGCCGCACAGACGATCTCAAGTGGAGTCGCTTACCTTTGGCCTTTGC
CTACAGAGAACCCTATCTGTTTGTGACCCACTTCAACTCACTCGAAGTAATTGAGATCCAGGCACGCTCCTCAGCAGGGACCCCTGCCCG
AGCGTACCTGGACATCCCGAACCCGCGCTACCTGGGCCCTGCCATTTCCTCAGGAGCGATTTACTTGGCGTCCTCATACCAGGATAAATT
AAGGGTCATTTGCTGCAAGGGAAACCTCGTGAAGGAGTCCGGCACTGAACACCACCGGGGCCCGTCCACCTCCCGCAGCAGCCCCAACAA
GCGAGGCCCACCCACGTACAACGAGCACATCACCAAGCGCGTGGCCTCCAGCCCAGCGCCGCCCGAAGGCCCCAGCCACCCGCGAGAGCC
AAGCACACCCCACCGCTACCGCGAGGGGCGGACCGAGCTGCGCAGGGACAAGTCTCCTGGCCGCCCCCTGGAGCGAGAGAAGTCCCCCGG
CCGGATGCTCAGCACGCGGAGAGAGCGGTCCCCCGGGAGGCTGTTTGAAGACAGCAGCAGGGGCCGGCTGCCTGCGGGAGCCGTGAGGAC
CCCGCTGTCCCAGGTGAACAAGGTCTGGGACCAGTCTTCAGTATAAATCTCAGCCAGAAAAACCAACTCCTCATCTTGATCTGCAGGAAA
ACACCAAACACACTATGGAACTCTGCTGATGGGGACCCAAGCGCCCACGTGCTCAGCCACCCTCTGGCTCAGCGGGGCCCAGACCCACCT
CGGCACGGACACCCCTGTCTCCAGGAGGGGCAGGTGGCTGAGGCTCTTCGGAGCTGTCAGCGCCCGGTGCCTGCCCTGGGCACCTCCCTG
CAGTCATCTCTTTGCACTTTGTTACTCTTTCAAAGCATTCACAAACTTTTGTACCTAGCTCTAGCCTGTACCAGTTAGTTCATCAAAGGA
AACCAACCGGGATGCTAACTACAACATGGTTAGAATCCTAATTAGCTACTTTAAGATCCTAGGATTGGTTGGTTTTTCTTTTTTTTTTCT
CTTTGTTTCTTTCCTTTTTTTTTTTTTTTTTTTAAGACAACAGAATTCTTAATAGATTTGAATAGCGACGTATTTCCTGTTGTAGTCATT
TTTAGCTCGACCACATCATCAGGTCTTTGCCACCGAGGCATAGTGTAGAACAGTCCCGGTCAGTTGGCCAACCTCCCGCAGCCAAGTAGG
TTCATCCTTGTTCCTGTTCATTCTCATAGATGGCCCTGCTTTCCCCAGGGTGACATCGTAGCCAAATGTTTACTGTTTTCATTGCCTTTT
ATGGCCTTGACGACTTCCCCTCCCACCAGCTGAGAATGTATGGAGGTCATCGGGGCCTCAGCTCGGAGGCAGTGACTTGGGGCCAAGGGA
CCTCGAGACGCTTTCCTTCCCCACCCCCCAGCGTCATCTCCCCAGCCTGCTGTTCCCGCTTTCCATATAGCTTTGGCCAGGAAAGCATGC
AATAGACTTGCTCGGAGCCCAGCACTCCTGGGTCTCGGGGTCGGGGAGGGGACGGGGGCACCCACTTCCTTGTCTGTGACGGCGTGTTGT
TCCCCACTCTGGGATGGGGAAGAGGCCCGTCGGGAGTTCTGCATGGCAGTTCACTGCATGTGCTGCCCCCTTGGGTTGCTCTGCCAATGT
ATTAATACCATCCCATAGCTCCTGCCAAATCGAGACCCTCTGACGACTTGCCGACTAACTGGCCACCACAAGCTGCAGTCTGTAGCACTG
AACAAACAAAAAACAAAACGCTCAAGCCTTACGACCAGAGAAGGATTTCAGCAAACCACCACCTCCCACTCAGTGTCCCCTCCAAACTTC
ACACTTCCCTGCCTGCAGAGGATGACTCTGTTCACACCCAATCCAGCGCGGTTCTACCCCACGAAACTGTGACTTTCCAAATGAGCCTTT
CCCTAGGGCTAGACCTAAGACCAGGAAGTTTGAGAAAGCAGCCGCAGCTCAACTCTTCCAGCTCCGCCAGGGTTGGGAAGTCCTTAGGTG
CAGTGCGGCTCCCACTGGGTCTGCGGACCCTCCTATTAGAGTACGAAATTCCTGGCAACTGGTACAGAACCAACCTAGAGGCTTTGCAGT
TGGCAAGCTAACTCGCGGCCTTATTTCTGCCTTTAATCTCCCACAAGGCATCTGTTGCTTTGGGTCCTCCACGACTCTTAGGCCCGCCTC
AACAACCCAGGCACCTCCTAGGTAGGCTCAAAGGTAGACCCGTTTCCACCGCAGCAGGTGAACATGACCGTGTTTTCAACTGTGTCCACA
GTTCAGATCCCTTTCCAGATTGCAACCTGGCCTGCATCCCAGCTCCTTCCTGCTCGTGTCTTAACCTAAGTGCTTTCTTGTTTGAAACGC
CTACAAACCTCCATGTGGTAGCTCCTTTGGCAAATGTCCTGCTGTGGCGTTTTATGTGTTGCTTGGAGTCTGTGGGGTCGTACTCCCTCC
CCTCCCGTCCCCAGGGCAGATTTGATTGAATGTTTGCTGAAGTTTTGTCTCTTGGTCCACAGTATTTGGAAAGGTCACTGAAAATGGGTC
TTTCAGTCTTGGCATTTCATTTAGGATCTCCATGAGAAATGGGCTTCTTGAGCCCTGAAAATGTATATTGTGTGTCTCATCTGTGAACTG
CTTTCTGCTATATAGAACTAGCTCAAAAGACTGTACATATTTACAAGAAACTTTATATTCGTAAAAAAAAAAAGAGGAAATTGAATTGGT
TTCTACTTTTTTATTGTAAAAGGTGCATTTTTCAACACTTACTTTTGGTTTCAATGGTGGTAGTTGTGGACAGCCATCTTCACTGGAGGG
TGGGGAGCTCCGTGTGACCACCAAGATGCCAGCAGGATATACCGTAACACGAAATTGCTGTCAAAAGCTTATTAGCATCAATCAAGATTC
TAGGTCTCCAAAAGTACAGGCTTTTTCTTCATTACCTTTTTTATTCAGAACGAGGAAGAGAACACAAGGAATGATTCAAGATCCACCTTG

>5685_5685_1_APPL2-CIT_APPL2_chr12_105629736_ENST00000258530_CIT_chr12_120198859_ENST00000261833_length(amino acids)=1368AA_BP=67
MARRGRARGRRGHGVAAASPEPRAGECSRPPRLLPSVLPTQPSAEPRRTMPAVDKLLLEEALQDSPQVLDNQIKKDLADKETLENMMQRH
EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK
ISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR
DEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTC
TMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKE
QKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLE
NIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSA
REEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVC
LDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIV
LEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALE
SVVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAG
EERALCLVDVKKVKQSLAQSHLPAQPDISPNIFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHF
TNYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLP
LAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRS
SPNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELRRDKSPGRPLEREKSPGRMLSTRRERSPGRLFEDSSRGRLPAG

--------------------------------------------------------------
>5685_5685_2_APPL2-CIT_APPL2_chr12_105629736_ENST00000258530_CIT_chr12_120198859_ENST00000392521_length(transcript)=6628nt_BP=280nt
TTTCCCTGCCGGGCGCGCCACACTTCCTGTTGATCCGGCTCGGCCGGGGGCTGGGCCGGCGGGCAGGCGGCGGCGGCCACTGGCCAGGCG
TGGACGCGCGCGGGGCCGCCGCGGGCACGGAGTGGCCGCCGCGTCGCCTGAGCCCAGAGCCGGGGAGTGCTCTCGGCCGCCGCGTCTCCT
GCCCTCTGTCCTTCCAACCCAGCCCTCGGCTGAGCCGCGCCGCACCATGCCCGCCGTGGACAAGCTCCTGCTAGAGGAGGCGTTGCAGGA
CAGCCCCCAGGTGTTGGACAATCAGATAAAGAAAGACCTGGCTGACAAGGAGACACTGGAGAACATGATGCAGAGACACGAGGAGGAGGC
CCATGAGAAGGGCAAAATTCTCAGCGAACAGAAGGCGATGATCAATGCTATGGATTCCAAGATCAGATCCCTGGAACAGAGGATTGTGGA
ACTGTCTGAAGCCAATAAACTTGCAGCAAATAGCAGTCTTTTTACCCAAAGGAACATGAAGGCCCAAGAAGAGATGATTTCTGAACTCAG
GCAACAGAAATTTTACCTGGAGACACAGGCTGGGAAGTTGGAGGCCCAGAACCGAAAACTGGAGGAGCAGCTGGAGAAGATCAGCCACCA
AGACCACAGTGACAAGAATCGGCTGCTGGAACTGGAGACAAGATTGCGGGAGGTCAGTCTAGAGCACGAGGAGCAGAAACTGGAGCTCAA
GCGCCAGCTCACAGAGCTACAGCTCTCCCTGCAGGAGCGCGAGTCACAGTTGACAGCCCTGCAGGCTGCACGGGCGGCCCTGGAGAGCCA
GCTTCGCCAGGCGAAGACAGAGCTGGAAGAGACCACAGCAGAAGCTGAAGAGGAGATCCAGGCACTCACGGCACATAGAGATGAAATCCA
GCGCAAATTTGATGCTCTTCGTAACAGCTGTACTGTAATCACAGACCTGGAGGAGCAGCTAAACCAGCTGACCGAGGACAACGCTGAACT
CAACAACCAAAACTTCTACTTGTCCAAACAACTCGATGAGGCTTCTGGCGCCAACGACGAGATTGTACAACTGCGAAGTGAAGTGGACCA
TCTCCGCCGGGAGATCACGGAACGAGAGATGCAGCTTACCAGCCAGAAGCAAACGATGGAGGCTCTGAAGACCACGTGCACCATGCTGGA
GGAACAGGTCATGGATTTGGAGGCCCTAAACGATGAGCTGCTAGAAAAAGAGCGGCAGTGGGAGGCCTGGAGGAGCGTCCTGGGTGATGA
GAAATCCCAGTTTGAGTGTCGGGTTCGAGAGCTGCAGAGAATGCTGGACACCGAGAAACAGAGCAGGGCGAGAGCCGATCAGCGGATCAC
CGAGTCTCGCCAGGTGGTGGAGCTGGCAGTGAAGGAGCACAAGGCTGAGATTCTCGCTCTGCAGCAGGCTCTCAAAGAGCAGAAGCTGAA
GGCCGAGAGCCTCTCTGACAAGCTCAATGACCTGGAGAAGAAGCATGCTATGCTTGAAATGAATGCCCGAAGCTTACAGCAGAAGCTGGA
GACTGAACGAGAGCTCAAACAGAGGCTTCTGGAAGAGCAAGCCAAATTACAGCAGCAGATGGACCTGCAGAAAAATCACATTTTCCGTCT
GACTCAAGGACTGCAAGAAGCTCTAGATCGGGCTGATCTACTGAAGACAGAAAGAAGTGACTTGGAGTATCAGCTGGAAAACATTCAGGT
TCTCTATTCTCATGAAAAGGTGAAAATGGAAGGCACTATTTCTCAACAAACCAAACTCATTGATTTTCTGCAAGCCAAAATGGACCAACC
TGCTAAAAAGAAAAAGGGTTTATTTAGTCGACGGAAAGAGGACCCTGCTTTACCCACACAGGTTCCTCTGCAGTACAATGAGCTGAAGCT
GGCCCTGGAGAAGGAGAAAGCTCGCTGTGCAGAGCTAGAGGAAGCCCTTCAGAAGACCCGCATCGAGCTCCGGTCCGCCCGGGAGGAAGC
TGCCCACCGCAAAGCAACGGACCACCCACACCCATCCACGCCAGCCACCGCGAGGCAGCAGATCGCCATGTCCGCCATCGTGCGGTCGCC
AGAGCACCAGCCCAGTGCCATGAGCCTGCTGGCCCCGCCATCCAGCCGCAGAAAGGAGTCTTCAACTCCAGAGGAATTTAGTCGGCGTCT
TAAGGAACGCATGCACCACAATATTCCTCACCGATTCAACGTAGGACTGAACATGCGAGCCACAAAGTGTGCTGTGTGTCTGGATACCGT
GCACTTTGGACGCCAGGCATCCAAATGTCTCGAATGTCAGGTGATGTGTCACCCCAAGTGCTCCACGTGCTTGCCAGCCACCTGCGGCTT
GCCTGCTGAATATGCCACACACTTCACCGAGGCCTTCTGCCGTGACAAAATGAACTCCCCAGGTCTCCAGACCAAGGAGCCCAGCAGCAG
CTTGCACCTGGAAGGGTGGATGAAGGTGCCCAGGAATAACAAACGAGGACAGCAAGGCTGGGACAGGAAGTACATTGTCCTGGAGGGATC
AAAAGTCCTCATTTATGACAATGAAGCCAGAGAAGCTGGACAGAGGCCGGTGGAAGAATTTGAGCTGTGCCTTCCCGACGGGGATGTATC
TATTCATGGTGCCGTTGGTGCTTCCGAACTCGCAAATACAGCCAAAGCAGATGTCCCATACATACTGAAGATGGAATCTCACCCGCACAC
CACCTGCTGGCCCGGGAGAACCCTCTACTTGCTAGCTCCCAGCTTCCCTGACAAACAGCGCTGGGTCACCGCCTTAGAATCAGTTGTCGC
AGGTGGGAGAGTTTCTAGGGAAAAAGCAGAAGCTGATGCTAAACTGCTTGGAAACTCCCTGCTGAAACTGGAAGGTGATGACCGTCTAGA
CATGAACTGCACGCTGCCCTTCAGTGACCAGGTGGTGTTGGTGGGCACCGAGGAAGGGCTCTACGCCCTGAATGTCTTGAAAAACTCCCT
AACCCATGTCCCAGGAATTGGAGCAGTCTTCCAAATTTATATTATCAAGGACCTGGAGAAGCTACTCATGATAGCAGGAGAAGAGCGGGC
ACTGTGTCTTGTGGACGTGAAGAAAGTGAAACAGTCCCTGGCCCAGTCCCACCTGCCTGCCCAGCCCGACATCTCACCCAACATTTTTGA
AGCTGTCAAGGGCTGCCACTTGTTTGGGGCAGGCAAGATTGAGAACGGGCTCTGCATCTGTGCAGCCATGCCCAGCAAAGTCGTCATTCT
CCGCTACAACGAAAACCTCAGCAAATACTGCATCCGGAAAGAGATAGAGACCTCAGAGCCCTGCAGCTGTATCCACTTCACCAATTACAG
TATCCTCATTGGAACCAATAAATTCTACGAAATCGACATGAAGCAGTACACGCTCGAGGAATTCCTGGATAAGAATGACCATTCCTTGGC
ACCTGCTGTGTTTGCCGCCTCTTCCAACAGCTTCCCTGTCTCAATCGTGCAGGTGAACAGCGCAGGGCAGCGAGAGGAGTACTTGCTGTG
TTTCCACGAATTTGGAGTGTTCGTGGATTCTTACGGAAGACGTAGCCGCACAGACGATCTCAAGTGGAGTCGCTTACCTTTGGCCTTTGC
CTACAGAGAACCCTATCTGTTTGTGACCCACTTCAACTCACTCGAAGTAATTGAGATCCAGGCACGCTCCTCAGCAGGGACCCCTGCCCG
AGCGTACCTGGACATCCCGAACCCGCGCTACCTGGGCCCTGCCATTTCCTCAGGAGCGATTTACTTGGCGTCCTCATACCAGGATAAATT
AAGGGTCATTTGCTGCAAGGGAAACCTCGTGAAGGAGTCCGGCACTGAACACCACCGGGGCCCGTCCACCTCCCGCAGCAGCCCCAACAA
GCGAGGCCCACCCACGTACAACGAGCACATCACCAAGCGCGTGGCCTCCAGCCCAGCGCCGCCCGAAGGCCCCAGCCACCCGCGAGAGCC
AAGCACACCCCACCGCTACCGCGAGGGGCGGACCGAGCTGCGCAGGGACAAGTCTCCTGGCCGCCCCCTGGAGCGAGAGAAGTCCCCCGG
CCGGATGCTCAGCACGCGGAGAGAGCGGTCCCCCGGGAGGCTGTTTGAAGACAGCAGCAGGGGCCGGCTGCCTGCGGGAGCCGTGAGGAC
CCCGCTGTCCCAGGTGAACAAGGTCTGGGACCAGTCTTCAGTATAAATCTCAGCCAGAAAAACCAACTCCTCATCTTGATCTGCAGGAAA
ACACCAAACACACTATGGAACTCTGCTGATGGGGACCCAAGCGCCCACGTGCTCAGCCACCCTCTGGCTCAGCGGGGCCCAGACCCACCT
CGGCACGGACACCCCTGTCTCCAGGAGGGGCAGGTGGCTGAGGCTCTTCGGAGCTGTCAGCGCCCGGTGCCTGCCCTGGGCACCTCCCTG
CAGTCATCTCTTTGCACTTTGTTACTCTTTCAAAGCATTCACAAACTTTTGTACCTAGCTCTAGCCTGTACCAGTTAGTTCATCAAAGGA
AACCAACCGGGATGCTAACTACAACATGGTTAGAATCCTAATTAGCTACTTTAAGATCCTAGGATTGGTTGGTTTTTCTTTTTTTTTTCT
CTTTGTTTCTTTCCTTTTTTTTTTTTTTTTTTTAAGACAACAGAATTCTTAATAGATTTGAATAGCGACGTATTTCCTGTTGTAGTCATT
TTTAGCTCGACCACATCATCAGGTCTTTGCCACCGAGGCATAGTGTAGAACAGTCCCGGTCAGTTGGCCAACCTCCCGCAGCCAAGTAGG
TTCATCCTTGTTCCTGTTCATTCTCATAGATGGCCCTGCTTTCCCCAGGGTGACATCGTAGCCAAATGTTTACTGTTTTCATTGCCTTTT
ATGGCCTTGACGACTTCCCCTCCCACCAGCTGAGAATGTATGGAGGTCATCGGGGCCTCAGCTCGGAGGCAGTGACTTGGGGCCAAGGGA
CCTCGAGACGCTTTCCTTCCCCACCCCCCAGCGTCATCTCCCCAGCCTGCTGTTCCCGCTTTCCATATAGCTTTGGCCAGGAAAGCATGC
AATAGACTTGCTCGGAGCCCAGCACTCCTGGGTCTCGGGGTCGGGGAGGGGACGGGGGCACCCACTTCCTTGTCTGTGACGGCGTGTTGT
TCCCCACTCTGGGATGGGGAAGAGGCCCGTCGGGAGTTCTGCATGGCAGTTCACTGCATGTGCTGCCCCCTTGGGTTGCTCTGCCAATGT
ATTAATACCATCCCATAGCTCCTGCCAAATCGAGACCCTCTGACGACTTGCCGACTAACTGGCCACCACAAGCTGCAGTCTGTAGCACTG
AACAAACAAAAAACAAAACGCTCAAGCCTTACGACCAGAGAAGGATTTCAGCAAACCACCACCTCCCACTCAGTGTCCCCTCCAAACTTC
ACACTTCCCTGCCTGCAGAGGATGACTCTGTTCACACCCAATCCAGCGCGGTTCTACCCCACGAAACTGTGACTTTCCAAATGAGCCTTT
CCCTAGGGCTAGACCTAAGACCAGGAAGTTTGAGAAAGCAGCCGCAGCTCAACTCTTCCAGCTCCGCCAGGGTTGGGAAGTCCTTAGGTG
CAGTGCGGCTCCCACTGGGTCTGCGGACCCTCCTATTAGAGTACGAAATTCCTGGCAACTGGTACAGAACCAACCTAGAGGCTTTGCAGT
TGGCAAGCTAACTCGCGGCCTTATTTCTGCCTTTAATCTCCCACAAGGCATCTGTTGCTTTGGGTCCTCCACGACTCTTAGGCCCGCCTC
AACAACCCAGGCACCTCCTAGGTAGGCTCAAAGGTAGACCCGTTTCCACCGCAGCAGGTGAACATGACCGTGTTTTCAACTGTGTCCACA
GTTCAGATCCCTTTCCAGATTGCAACCTGGCCTGCATCCCAGCTCCTTCCTGCTCGTGTCTTAACCTAAGTGCTTTCTTGTTTGAAACGC
CTACAAACCTCCATGTGGTAGCTCCTTTGGCAAATGTCCTGCTGTGGCGTTTTATGTGTTGCTTGGAGTCTGTGGGGTCGTACTCCCTCC
CCTCCCGTCCCCAGGGCAGATTTGATTGAATGTTTGCTGAAGTTTTGTCTCTTGGTCCACAGTATTTGGAAAGGTCACTGAAAATGGGTC
TTTCAGTCTTGGCATTTCATTTAGGATCTCCATGAGAAATGGGCTTCTTGAGCCCTGAAAATGTATATTGTGTGTCTCATCTGTGAACTG
CTTTCTGCTATATAGAACTAGCTCAAAAGACTGTACATATTTACAAGAAACTTTATATTCGTAAAAAAAAAAAGAGGAAATTGAATTGGT
TTCTACTTTTTTATTGTAAAAGGTGCATTTTTCAACACTTACTTTTGGTTTCAATGGTGGTAGTTGTGGACAGCCATCTTCACTGGAGGG
TGGGGAGCTCCGTGTGACCACCAAGATGCCAGCAGGATATACCGTAACACGAAATTGCTGTCAAAAGCTTATTAGCATCAATCAAGATTC
TAGGTCTCCAAAAGTACAGGCTTTTTCTTCATTACCTTTTTTATTCAGAACGAGGAAGAGAACACAAGGAATGATTCAAGATCCACCTTG

>5685_5685_2_APPL2-CIT_APPL2_chr12_105629736_ENST00000258530_CIT_chr12_120198859_ENST00000392521_length(amino acids)=1368AA_BP=67
MARRGRARGRRGHGVAAASPEPRAGECSRPPRLLPSVLPTQPSAEPRRTMPAVDKLLLEEALQDSPQVLDNQIKKDLADKETLENMMQRH
EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK
ISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR
DEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTC
TMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKE
QKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLE
NIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSA
REEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVC
LDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIV
LEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALE
SVVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAG
EERALCLVDVKKVKQSLAQSHLPAQPDISPNIFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHF
TNYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLP
LAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRS
SPNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELRRDKSPGRPLEREKSPGRMLSTRRERSPGRLFEDSSRGRLPAG

--------------------------------------------------------------
>5685_5685_3_APPL2-CIT_APPL2_chr12_105629736_ENST00000551662_CIT_chr12_120198859_ENST00000261833_length(transcript)=6472nt_BP=125nt
AGTGCTCTCGGCCGCCGCGTCTCCTGCCCTCTGTCCTTCCAACCCAGCCCTCGGCTGAGCCGCGCCGCACCATGCCCGCCGTGGACAAGC
TCCTGCTAGAGGAGGCGTTGCAGGACAGCCCCCAGGTGTTGGACAATCAGATAAAGAAAGACCTGGCTGACAAGGAGACACTGGAGAACA
TGATGCAGAGACACGAGGAGGAGGCCCATGAGAAGGGCAAAATTCTCAGCGAACAGAAGGCGATGATCAATGCTATGGATTCCAAGATCA
GATCCCTGGAACAGAGGATTGTGGAACTGTCTGAAGCCAATAAACTTGCAGCAAATAGCAGTCTTTTTACCCAAAGGAACATGAAGGCCC
AAGAAGAGATGATTTCTGAACTCAGGCAACAGAAATTTTACCTGGAGACACAGGCTGGGAAGTTGGAGGCCCAGAACCGAAAACTGGAGG
AGCAGCTGGAGAAGATCAGCCACCAAGACCACAGTGACAAGAATCGGCTGCTGGAACTGGAGACAAGATTGCGGGAGGTCAGTCTAGAGC
ACGAGGAGCAGAAACTGGAGCTCAAGCGCCAGCTCACAGAGCTACAGCTCTCCCTGCAGGAGCGCGAGTCACAGTTGACAGCCCTGCAGG
CTGCACGGGCGGCCCTGGAGAGCCAGCTTCGCCAGGCGAAGACAGAGCTGGAAGAGACCACAGCAGAAGCTGAAGAGGAGATCCAGGCAC
TCACGGCACATAGAGATGAAATCCAGCGCAAATTTGATGCTCTTCGTAACAGCTGTACTGTAATCACAGACCTGGAGGAGCAGCTAAACC
AGCTGACCGAGGACAACGCTGAACTCAACAACCAAAACTTCTACTTGTCCAAACAACTCGATGAGGCTTCTGGCGCCAACGACGAGATTG
TACAACTGCGAAGTGAAGTGGACCATCTCCGCCGGGAGATCACGGAACGAGAGATGCAGCTTACCAGCCAGAAGCAAACGATGGAGGCTC
TGAAGACCACGTGCACCATGCTGGAGGAACAGGTCATGGATTTGGAGGCCCTAAACGATGAGCTGCTAGAAAAAGAGCGGCAGTGGGAGG
CCTGGAGGAGCGTCCTGGGTGATGAGAAATCCCAGTTTGAGTGTCGGGTTCGAGAGCTGCAGAGAATGCTGGACACCGAGAAACAGAGCA
GGGCGAGAGCCGATCAGCGGATCACCGAGTCTCGCCAGGTGGTGGAGCTGGCAGTGAAGGAGCACAAGGCTGAGATTCTCGCTCTGCAGC
AGGCTCTCAAAGAGCAGAAGCTGAAGGCCGAGAGCCTCTCTGACAAGCTCAATGACCTGGAGAAGAAGCATGCTATGCTTGAAATGAATG
CCCGAAGCTTACAGCAGAAGCTGGAGACTGAACGAGAGCTCAAACAGAGGCTTCTGGAAGAGCAAGCCAAATTACAGCAGCAGATGGACC
TGCAGAAAAATCACATTTTCCGTCTGACTCAAGGACTGCAAGAAGCTCTAGATCGGGCTGATCTACTGAAGACAGAAAGAAGTGACTTGG
AGTATCAGCTGGAAAACATTCAGGTTCTCTATTCTCATGAAAAGGTGAAAATGGAAGGCACTATTTCTCAACAAACCAAACTCATTGATT
TTCTGCAAGCCAAAATGGACCAACCTGCTAAAAAGAAAAAGGGTTTATTTAGTCGACGGAAAGAGGACCCTGCTTTACCCACACAGGTTC
CTCTGCAGTACAATGAGCTGAAGCTGGCCCTGGAGAAGGAGAAAGCTCGCTGTGCAGAGCTAGAGGAAGCCCTTCAGAAGACCCGCATCG
AGCTCCGGTCCGCCCGGGAGGAAGCTGCCCACCGCAAAGCAACGGACCACCCACACCCATCCACGCCAGCCACCGCGAGGCAGCAGATCG
CCATGTCCGCCATCGTGCGGTCGCCAGAGCACCAGCCCAGTGCCATGAGCCTGCTGGCCCCGCCATCCAGCCGCAGAAAGGAGTCTTCAA
CTCCAGAGGAATTTAGTCGGCGTCTTAAGGAACGCATGCACCACAATATTCCTCACCGATTCAACGTAGGACTGAACATGCGAGCCACAA
AGTGTGCTGTGTGTCTGGATACCGTGCACTTTGGACGCCAGGCATCCAAATGTCTCGAATGTCAGGTGATGTGTCACCCCAAGTGCTCCA
CGTGCTTGCCAGCCACCTGCGGCTTGCCTGCTGAATATGCCACACACTTCACCGAGGCCTTCTGCCGTGACAAAATGAACTCCCCAGGTC
TCCAGACCAAGGAGCCCAGCAGCAGCTTGCACCTGGAAGGGTGGATGAAGGTGCCCAGGAATAACAAACGAGGACAGCAAGGCTGGGACA
GGAAGTACATTGTCCTGGAGGGATCAAAAGTCCTCATTTATGACAATGAAGCCAGAGAAGCTGGACAGAGGCCGGTGGAAGAATTTGAGC
TGTGCCTTCCCGACGGGGATGTATCTATTCATGGTGCCGTTGGTGCTTCCGAACTCGCAAATACAGCCAAAGCAGATGTCCCATACATAC
TGAAGATGGAATCTCACCCGCACACCACCTGCTGGCCCGGGAGAACCCTCTACTTGCTAGCTCCCAGCTTCCCTGACAAACAGCGCTGGG
TCACCGCCTTAGAATCAGTTGTCGCAGGTGGGAGAGTTTCTAGGGAAAAAGCAGAAGCTGATGCTAAACTGCTTGGAAACTCCCTGCTGA
AACTGGAAGGTGATGACCGTCTAGACATGAACTGCACGCTGCCCTTCAGTGACCAGGTGGTGTTGGTGGGCACCGAGGAAGGGCTCTACG
CCCTGAATGTCTTGAAAAACTCCCTAACCCATGTCCCAGGAATTGGAGCAGTCTTCCAAATTTATATTATCAAGGACCTGGAGAAGCTAC
TCATGATAGCAGGAGAAGAGCGGGCACTGTGTCTTGTGGACGTGAAGAAAGTGAAACAGTCCCTGGCCCAGTCCCACCTGCCTGCCCAGC
CCGACATCTCACCCAACATTTTTGAAGCTGTCAAGGGCTGCCACTTGTTTGGGGCAGGCAAGATTGAGAACGGGCTCTGCATCTGTGCAG
CCATGCCCAGCAAAGTCGTCATTCTCCGCTACAACGAAAACCTCAGCAAATACTGCATCCGGAAAGAGATAGAGACCTCAGAGCCCTGCA
GCTGTATCCACTTCACCAATTACAGTATCCTCATTGGAACCAATAAATTCTACGAAATCGACATGAAGCAGTACACGCTCGAGGAATTCC
TGGATAAGAATGACCATTCCTTGGCACCTGCTGTGTTTGCCGCCTCTTCCAACAGCTTCCCTGTCTCAATCGTGCAGGTGAACAGCGCAG
GGCAGCGAGAGGAGTACTTGCTGTGTTTCCACGAATTTGGAGTGTTCGTGGATTCTTACGGAAGACGTAGCCGCACAGACGATCTCAAGT
GGAGTCGCTTACCTTTGGCCTTTGCCTACAGAGAACCCTATCTGTTTGTGACCCACTTCAACTCACTCGAAGTAATTGAGATCCAGGCAC
GCTCCTCAGCAGGGACCCCTGCCCGAGCGTACCTGGACATCCCGAACCCGCGCTACCTGGGCCCTGCCATTTCCTCAGGAGCGATTTACT
TGGCGTCCTCATACCAGGATAAATTAAGGGTCATTTGCTGCAAGGGAAACCTCGTGAAGGAGTCCGGCACTGAACACCACCGGGGCCCGT
CCACCTCCCGCAGCAGCCCCAACAAGCGAGGCCCACCCACGTACAACGAGCACATCACCAAGCGCGTGGCCTCCAGCCCAGCGCCGCCCG
AAGGCCCCAGCCACCCGCGAGAGCCAAGCACACCCCACCGCTACCGCGAGGGGCGGACCGAGCTGCGCAGGGACAAGTCTCCTGGCCGCC
CCCTGGAGCGAGAGAAGTCCCCCGGCCGGATGCTCAGCACGCGGAGAGAGCGGTCCCCCGGGAGGCTGTTTGAAGACAGCAGCAGGGGCC
GGCTGCCTGCGGGAGCCGTGAGGACCCCGCTGTCCCAGGTGAACAAGGTCTGGGACCAGTCTTCAGTATAAATCTCAGCCAGAAAAACCA
ACTCCTCATCTTGATCTGCAGGAAAACACCAAACACACTATGGAACTCTGCTGATGGGGACCCAAGCGCCCACGTGCTCAGCCACCCTCT
GGCTCAGCGGGGCCCAGACCCACCTCGGCACGGACACCCCTGTCTCCAGGAGGGGCAGGTGGCTGAGGCTCTTCGGAGCTGTCAGCGCCC
GGTGCCTGCCCTGGGCACCTCCCTGCAGTCATCTCTTTGCACTTTGTTACTCTTTCAAAGCATTCACAAACTTTTGTACCTAGCTCTAGC
CTGTACCAGTTAGTTCATCAAAGGAAACCAACCGGGATGCTAACTACAACATGGTTAGAATCCTAATTAGCTACTTTAAGATCCTAGGAT
TGGTTGGTTTTTCTTTTTTTTTTCTCTTTGTTTCTTTCCTTTTTTTTTTTTTTTTTTTAAGACAACAGAATTCTTAATAGATTTGAATAG
CGACGTATTTCCTGTTGTAGTCATTTTTAGCTCGACCACATCATCAGGTCTTTGCCACCGAGGCATAGTGTAGAACAGTCCCGGTCAGTT
GGCCAACCTCCCGCAGCCAAGTAGGTTCATCCTTGTTCCTGTTCATTCTCATAGATGGCCCTGCTTTCCCCAGGGTGACATCGTAGCCAA
ATGTTTACTGTTTTCATTGCCTTTTATGGCCTTGACGACTTCCCCTCCCACCAGCTGAGAATGTATGGAGGTCATCGGGGCCTCAGCTCG
GAGGCAGTGACTTGGGGCCAAGGGACCTCGAGACGCTTTCCTTCCCCACCCCCCAGCGTCATCTCCCCAGCCTGCTGTTCCCGCTTTCCA
TATAGCTTTGGCCAGGAAAGCATGCAATAGACTTGCTCGGAGCCCAGCACTCCTGGGTCTCGGGGTCGGGGAGGGGACGGGGGCACCCAC
TTCCTTGTCTGTGACGGCGTGTTGTTCCCCACTCTGGGATGGGGAAGAGGCCCGTCGGGAGTTCTGCATGGCAGTTCACTGCATGTGCTG
CCCCCTTGGGTTGCTCTGCCAATGTATTAATACCATCCCATAGCTCCTGCCAAATCGAGACCCTCTGACGACTTGCCGACTAACTGGCCA
CCACAAGCTGCAGTCTGTAGCACTGAACAAACAAAAAACAAAACGCTCAAGCCTTACGACCAGAGAAGGATTTCAGCAAACCACCACCTC
CCACTCAGTGTCCCCTCCAAACTTCACACTTCCCTGCCTGCAGAGGATGACTCTGTTCACACCCAATCCAGCGCGGTTCTACCCCACGAA
ACTGTGACTTTCCAAATGAGCCTTTCCCTAGGGCTAGACCTAAGACCAGGAAGTTTGAGAAAGCAGCCGCAGCTCAACTCTTCCAGCTCC
GCCAGGGTTGGGAAGTCCTTAGGTGCAGTGCGGCTCCCACTGGGTCTGCGGACCCTCCTATTAGAGTACGAAATTCCTGGCAACTGGTAC
AGAACCAACCTAGAGGCTTTGCAGTTGGCAAGCTAACTCGCGGCCTTATTTCTGCCTTTAATCTCCCACAAGGCATCTGTTGCTTTGGGT
CCTCCACGACTCTTAGGCCCGCCTCAACAACCCAGGCACCTCCTAGGTAGGCTCAAAGGTAGACCCGTTTCCACCGCAGCAGGTGAACAT
GACCGTGTTTTCAACTGTGTCCACAGTTCAGATCCCTTTCCAGATTGCAACCTGGCCTGCATCCCAGCTCCTTCCTGCTCGTGTCTTAAC
CTAAGTGCTTTCTTGTTTGAAACGCCTACAAACCTCCATGTGGTAGCTCCTTTGGCAAATGTCCTGCTGTGGCGTTTTATGTGTTGCTTG
GAGTCTGTGGGGTCGTACTCCCTCCCCTCCCGTCCCCAGGGCAGATTTGATTGAATGTTTGCTGAAGTTTTGTCTCTTGGTCCACAGTAT
TTGGAAAGGTCACTGAAAATGGGTCTTTCAGTCTTGGCATTTCATTTAGGATCTCCATGAGAAATGGGCTTCTTGAGCCCTGAAAATGTA
TATTGTGTGTCTCATCTGTGAACTGCTTTCTGCTATATAGAACTAGCTCAAAAGACTGTACATATTTACAAGAAACTTTATATTCGTAAA
AAAAAAAAGAGGAAATTGAATTGGTTTCTACTTTTTTATTGTAAAAGGTGCATTTTTCAACACTTACTTTTGGTTTCAATGGTGGTAGTT
GTGGACAGCCATCTTCACTGGAGGGTGGGGAGCTCCGTGTGACCACCAAGATGCCAGCAGGATATACCGTAACACGAAATTGCTGTCAAA
AGCTTATTAGCATCAATCAAGATTCTAGGTCTCCAAAAGTACAGGCTTTTTCTTCATTACCTTTTTTATTCAGAACGAGGAAGAGAACAC

>5685_5685_3_APPL2-CIT_APPL2_chr12_105629736_ENST00000551662_CIT_chr12_120198859_ENST00000261833_length(amino acids)=1335AA_BP=34
MPSVLPTQPSAEPRRTMPAVDKLLLEEALQDSPQVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIV
ELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLEL
KRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAE
LNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGD
EKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL
ETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQ
PAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRS
PEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCG
LPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDV
SIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAKLLGNSLLKLEGDDRL
DMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPNIF
EAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQYTLEEFLDKNDHSL
APAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPA
RAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSSPNKRGPPTYNEHITKRVASSPAPPEGPSHPRE

--------------------------------------------------------------
>5685_5685_4_APPL2-CIT_APPL2_chr12_105629736_ENST00000551662_CIT_chr12_120198859_ENST00000392521_length(transcript)=6473nt_BP=125nt
AGTGCTCTCGGCCGCCGCGTCTCCTGCCCTCTGTCCTTCCAACCCAGCCCTCGGCTGAGCCGCGCCGCACCATGCCCGCCGTGGACAAGC
TCCTGCTAGAGGAGGCGTTGCAGGACAGCCCCCAGGTGTTGGACAATCAGATAAAGAAAGACCTGGCTGACAAGGAGACACTGGAGAACA
TGATGCAGAGACACGAGGAGGAGGCCCATGAGAAGGGCAAAATTCTCAGCGAACAGAAGGCGATGATCAATGCTATGGATTCCAAGATCA
GATCCCTGGAACAGAGGATTGTGGAACTGTCTGAAGCCAATAAACTTGCAGCAAATAGCAGTCTTTTTACCCAAAGGAACATGAAGGCCC
AAGAAGAGATGATTTCTGAACTCAGGCAACAGAAATTTTACCTGGAGACACAGGCTGGGAAGTTGGAGGCCCAGAACCGAAAACTGGAGG
AGCAGCTGGAGAAGATCAGCCACCAAGACCACAGTGACAAGAATCGGCTGCTGGAACTGGAGACAAGATTGCGGGAGGTCAGTCTAGAGC
ACGAGGAGCAGAAACTGGAGCTCAAGCGCCAGCTCACAGAGCTACAGCTCTCCCTGCAGGAGCGCGAGTCACAGTTGACAGCCCTGCAGG
CTGCACGGGCGGCCCTGGAGAGCCAGCTTCGCCAGGCGAAGACAGAGCTGGAAGAGACCACAGCAGAAGCTGAAGAGGAGATCCAGGCAC
TCACGGCACATAGAGATGAAATCCAGCGCAAATTTGATGCTCTTCGTAACAGCTGTACTGTAATCACAGACCTGGAGGAGCAGCTAAACC
AGCTGACCGAGGACAACGCTGAACTCAACAACCAAAACTTCTACTTGTCCAAACAACTCGATGAGGCTTCTGGCGCCAACGACGAGATTG
TACAACTGCGAAGTGAAGTGGACCATCTCCGCCGGGAGATCACGGAACGAGAGATGCAGCTTACCAGCCAGAAGCAAACGATGGAGGCTC
TGAAGACCACGTGCACCATGCTGGAGGAACAGGTCATGGATTTGGAGGCCCTAAACGATGAGCTGCTAGAAAAAGAGCGGCAGTGGGAGG
CCTGGAGGAGCGTCCTGGGTGATGAGAAATCCCAGTTTGAGTGTCGGGTTCGAGAGCTGCAGAGAATGCTGGACACCGAGAAACAGAGCA
GGGCGAGAGCCGATCAGCGGATCACCGAGTCTCGCCAGGTGGTGGAGCTGGCAGTGAAGGAGCACAAGGCTGAGATTCTCGCTCTGCAGC
AGGCTCTCAAAGAGCAGAAGCTGAAGGCCGAGAGCCTCTCTGACAAGCTCAATGACCTGGAGAAGAAGCATGCTATGCTTGAAATGAATG
CCCGAAGCTTACAGCAGAAGCTGGAGACTGAACGAGAGCTCAAACAGAGGCTTCTGGAAGAGCAAGCCAAATTACAGCAGCAGATGGACC
TGCAGAAAAATCACATTTTCCGTCTGACTCAAGGACTGCAAGAAGCTCTAGATCGGGCTGATCTACTGAAGACAGAAAGAAGTGACTTGG
AGTATCAGCTGGAAAACATTCAGGTTCTCTATTCTCATGAAAAGGTGAAAATGGAAGGCACTATTTCTCAACAAACCAAACTCATTGATT
TTCTGCAAGCCAAAATGGACCAACCTGCTAAAAAGAAAAAGGGTTTATTTAGTCGACGGAAAGAGGACCCTGCTTTACCCACACAGGTTC
CTCTGCAGTACAATGAGCTGAAGCTGGCCCTGGAGAAGGAGAAAGCTCGCTGTGCAGAGCTAGAGGAAGCCCTTCAGAAGACCCGCATCG
AGCTCCGGTCCGCCCGGGAGGAAGCTGCCCACCGCAAAGCAACGGACCACCCACACCCATCCACGCCAGCCACCGCGAGGCAGCAGATCG
CCATGTCCGCCATCGTGCGGTCGCCAGAGCACCAGCCCAGTGCCATGAGCCTGCTGGCCCCGCCATCCAGCCGCAGAAAGGAGTCTTCAA
CTCCAGAGGAATTTAGTCGGCGTCTTAAGGAACGCATGCACCACAATATTCCTCACCGATTCAACGTAGGACTGAACATGCGAGCCACAA
AGTGTGCTGTGTGTCTGGATACCGTGCACTTTGGACGCCAGGCATCCAAATGTCTCGAATGTCAGGTGATGTGTCACCCCAAGTGCTCCA
CGTGCTTGCCAGCCACCTGCGGCTTGCCTGCTGAATATGCCACACACTTCACCGAGGCCTTCTGCCGTGACAAAATGAACTCCCCAGGTC
TCCAGACCAAGGAGCCCAGCAGCAGCTTGCACCTGGAAGGGTGGATGAAGGTGCCCAGGAATAACAAACGAGGACAGCAAGGCTGGGACA
GGAAGTACATTGTCCTGGAGGGATCAAAAGTCCTCATTTATGACAATGAAGCCAGAGAAGCTGGACAGAGGCCGGTGGAAGAATTTGAGC
TGTGCCTTCCCGACGGGGATGTATCTATTCATGGTGCCGTTGGTGCTTCCGAACTCGCAAATACAGCCAAAGCAGATGTCCCATACATAC
TGAAGATGGAATCTCACCCGCACACCACCTGCTGGCCCGGGAGAACCCTCTACTTGCTAGCTCCCAGCTTCCCTGACAAACAGCGCTGGG
TCACCGCCTTAGAATCAGTTGTCGCAGGTGGGAGAGTTTCTAGGGAAAAAGCAGAAGCTGATGCTAAACTGCTTGGAAACTCCCTGCTGA
AACTGGAAGGTGATGACCGTCTAGACATGAACTGCACGCTGCCCTTCAGTGACCAGGTGGTGTTGGTGGGCACCGAGGAAGGGCTCTACG
CCCTGAATGTCTTGAAAAACTCCCTAACCCATGTCCCAGGAATTGGAGCAGTCTTCCAAATTTATATTATCAAGGACCTGGAGAAGCTAC
TCATGATAGCAGGAGAAGAGCGGGCACTGTGTCTTGTGGACGTGAAGAAAGTGAAACAGTCCCTGGCCCAGTCCCACCTGCCTGCCCAGC
CCGACATCTCACCCAACATTTTTGAAGCTGTCAAGGGCTGCCACTTGTTTGGGGCAGGCAAGATTGAGAACGGGCTCTGCATCTGTGCAG
CCATGCCCAGCAAAGTCGTCATTCTCCGCTACAACGAAAACCTCAGCAAATACTGCATCCGGAAAGAGATAGAGACCTCAGAGCCCTGCA
GCTGTATCCACTTCACCAATTACAGTATCCTCATTGGAACCAATAAATTCTACGAAATCGACATGAAGCAGTACACGCTCGAGGAATTCC
TGGATAAGAATGACCATTCCTTGGCACCTGCTGTGTTTGCCGCCTCTTCCAACAGCTTCCCTGTCTCAATCGTGCAGGTGAACAGCGCAG
GGCAGCGAGAGGAGTACTTGCTGTGTTTCCACGAATTTGGAGTGTTCGTGGATTCTTACGGAAGACGTAGCCGCACAGACGATCTCAAGT
GGAGTCGCTTACCTTTGGCCTTTGCCTACAGAGAACCCTATCTGTTTGTGACCCACTTCAACTCACTCGAAGTAATTGAGATCCAGGCAC
GCTCCTCAGCAGGGACCCCTGCCCGAGCGTACCTGGACATCCCGAACCCGCGCTACCTGGGCCCTGCCATTTCCTCAGGAGCGATTTACT
TGGCGTCCTCATACCAGGATAAATTAAGGGTCATTTGCTGCAAGGGAAACCTCGTGAAGGAGTCCGGCACTGAACACCACCGGGGCCCGT
CCACCTCCCGCAGCAGCCCCAACAAGCGAGGCCCACCCACGTACAACGAGCACATCACCAAGCGCGTGGCCTCCAGCCCAGCGCCGCCCG
AAGGCCCCAGCCACCCGCGAGAGCCAAGCACACCCCACCGCTACCGCGAGGGGCGGACCGAGCTGCGCAGGGACAAGTCTCCTGGCCGCC
CCCTGGAGCGAGAGAAGTCCCCCGGCCGGATGCTCAGCACGCGGAGAGAGCGGTCCCCCGGGAGGCTGTTTGAAGACAGCAGCAGGGGCC
GGCTGCCTGCGGGAGCCGTGAGGACCCCGCTGTCCCAGGTGAACAAGGTCTGGGACCAGTCTTCAGTATAAATCTCAGCCAGAAAAACCA
ACTCCTCATCTTGATCTGCAGGAAAACACCAAACACACTATGGAACTCTGCTGATGGGGACCCAAGCGCCCACGTGCTCAGCCACCCTCT
GGCTCAGCGGGGCCCAGACCCACCTCGGCACGGACACCCCTGTCTCCAGGAGGGGCAGGTGGCTGAGGCTCTTCGGAGCTGTCAGCGCCC
GGTGCCTGCCCTGGGCACCTCCCTGCAGTCATCTCTTTGCACTTTGTTACTCTTTCAAAGCATTCACAAACTTTTGTACCTAGCTCTAGC
CTGTACCAGTTAGTTCATCAAAGGAAACCAACCGGGATGCTAACTACAACATGGTTAGAATCCTAATTAGCTACTTTAAGATCCTAGGAT
TGGTTGGTTTTTCTTTTTTTTTTCTCTTTGTTTCTTTCCTTTTTTTTTTTTTTTTTTTAAGACAACAGAATTCTTAATAGATTTGAATAG
CGACGTATTTCCTGTTGTAGTCATTTTTAGCTCGACCACATCATCAGGTCTTTGCCACCGAGGCATAGTGTAGAACAGTCCCGGTCAGTT
GGCCAACCTCCCGCAGCCAAGTAGGTTCATCCTTGTTCCTGTTCATTCTCATAGATGGCCCTGCTTTCCCCAGGGTGACATCGTAGCCAA
ATGTTTACTGTTTTCATTGCCTTTTATGGCCTTGACGACTTCCCCTCCCACCAGCTGAGAATGTATGGAGGTCATCGGGGCCTCAGCTCG
GAGGCAGTGACTTGGGGCCAAGGGACCTCGAGACGCTTTCCTTCCCCACCCCCCAGCGTCATCTCCCCAGCCTGCTGTTCCCGCTTTCCA
TATAGCTTTGGCCAGGAAAGCATGCAATAGACTTGCTCGGAGCCCAGCACTCCTGGGTCTCGGGGTCGGGGAGGGGACGGGGGCACCCAC
TTCCTTGTCTGTGACGGCGTGTTGTTCCCCACTCTGGGATGGGGAAGAGGCCCGTCGGGAGTTCTGCATGGCAGTTCACTGCATGTGCTG
CCCCCTTGGGTTGCTCTGCCAATGTATTAATACCATCCCATAGCTCCTGCCAAATCGAGACCCTCTGACGACTTGCCGACTAACTGGCCA
CCACAAGCTGCAGTCTGTAGCACTGAACAAACAAAAAACAAAACGCTCAAGCCTTACGACCAGAGAAGGATTTCAGCAAACCACCACCTC
CCACTCAGTGTCCCCTCCAAACTTCACACTTCCCTGCCTGCAGAGGATGACTCTGTTCACACCCAATCCAGCGCGGTTCTACCCCACGAA
ACTGTGACTTTCCAAATGAGCCTTTCCCTAGGGCTAGACCTAAGACCAGGAAGTTTGAGAAAGCAGCCGCAGCTCAACTCTTCCAGCTCC
GCCAGGGTTGGGAAGTCCTTAGGTGCAGTGCGGCTCCCACTGGGTCTGCGGACCCTCCTATTAGAGTACGAAATTCCTGGCAACTGGTAC
AGAACCAACCTAGAGGCTTTGCAGTTGGCAAGCTAACTCGCGGCCTTATTTCTGCCTTTAATCTCCCACAAGGCATCTGTTGCTTTGGGT
CCTCCACGACTCTTAGGCCCGCCTCAACAACCCAGGCACCTCCTAGGTAGGCTCAAAGGTAGACCCGTTTCCACCGCAGCAGGTGAACAT
GACCGTGTTTTCAACTGTGTCCACAGTTCAGATCCCTTTCCAGATTGCAACCTGGCCTGCATCCCAGCTCCTTCCTGCTCGTGTCTTAAC
CTAAGTGCTTTCTTGTTTGAAACGCCTACAAACCTCCATGTGGTAGCTCCTTTGGCAAATGTCCTGCTGTGGCGTTTTATGTGTTGCTTG
GAGTCTGTGGGGTCGTACTCCCTCCCCTCCCGTCCCCAGGGCAGATTTGATTGAATGTTTGCTGAAGTTTTGTCTCTTGGTCCACAGTAT
TTGGAAAGGTCACTGAAAATGGGTCTTTCAGTCTTGGCATTTCATTTAGGATCTCCATGAGAAATGGGCTTCTTGAGCCCTGAAAATGTA
TATTGTGTGTCTCATCTGTGAACTGCTTTCTGCTATATAGAACTAGCTCAAAAGACTGTACATATTTACAAGAAACTTTATATTCGTAAA
AAAAAAAAGAGGAAATTGAATTGGTTTCTACTTTTTTATTGTAAAAGGTGCATTTTTCAACACTTACTTTTGGTTTCAATGGTGGTAGTT
GTGGACAGCCATCTTCACTGGAGGGTGGGGAGCTCCGTGTGACCACCAAGATGCCAGCAGGATATACCGTAACACGAAATTGCTGTCAAA
AGCTTATTAGCATCAATCAAGATTCTAGGTCTCCAAAAGTACAGGCTTTTTCTTCATTACCTTTTTTATTCAGAACGAGGAAGAGAACAC

>5685_5685_4_APPL2-CIT_APPL2_chr12_105629736_ENST00000551662_CIT_chr12_120198859_ENST00000392521_length(amino acids)=1335AA_BP=34
MPSVLPTQPSAEPRRTMPAVDKLLLEEALQDSPQVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIV
ELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLEL
KRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAE
LNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGD
EKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL
ETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQ
PAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRS
PEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCG
LPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDV
SIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAKLLGNSLLKLEGDDRL
DMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPNIF
EAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQYTLEEFLDKNDHSL
APAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPA
RAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSSPNKRGPPTYNEHITKRVASSPAPPEGPSHPRE

--------------------------------------------------------------
>5685_5685_5_APPL2-CIT_APPL2_chr12_105629737_ENST00000258530_CIT_chr12_120198859_ENST00000261833_length(transcript)=6627nt_BP=280nt
TTTCCCTGCCGGGCGCGCCACACTTCCTGTTGATCCGGCTCGGCCGGGGGCTGGGCCGGCGGGCAGGCGGCGGCGGCCACTGGCCAGGCG
TGGACGCGCGCGGGGCCGCCGCGGGCACGGAGTGGCCGCCGCGTCGCCTGAGCCCAGAGCCGGGGAGTGCTCTCGGCCGCCGCGTCTCCT
GCCCTCTGTCCTTCCAACCCAGCCCTCGGCTGAGCCGCGCCGCACCATGCCCGCCGTGGACAAGCTCCTGCTAGAGGAGGCGTTGCAGGA
CAGCCCCCAGGTGTTGGACAATCAGATAAAGAAAGACCTGGCTGACAAGGAGACACTGGAGAACATGATGCAGAGACACGAGGAGGAGGC
CCATGAGAAGGGCAAAATTCTCAGCGAACAGAAGGCGATGATCAATGCTATGGATTCCAAGATCAGATCCCTGGAACAGAGGATTGTGGA
ACTGTCTGAAGCCAATAAACTTGCAGCAAATAGCAGTCTTTTTACCCAAAGGAACATGAAGGCCCAAGAAGAGATGATTTCTGAACTCAG
GCAACAGAAATTTTACCTGGAGACACAGGCTGGGAAGTTGGAGGCCCAGAACCGAAAACTGGAGGAGCAGCTGGAGAAGATCAGCCACCA
AGACCACAGTGACAAGAATCGGCTGCTGGAACTGGAGACAAGATTGCGGGAGGTCAGTCTAGAGCACGAGGAGCAGAAACTGGAGCTCAA
GCGCCAGCTCACAGAGCTACAGCTCTCCCTGCAGGAGCGCGAGTCACAGTTGACAGCCCTGCAGGCTGCACGGGCGGCCCTGGAGAGCCA
GCTTCGCCAGGCGAAGACAGAGCTGGAAGAGACCACAGCAGAAGCTGAAGAGGAGATCCAGGCACTCACGGCACATAGAGATGAAATCCA
GCGCAAATTTGATGCTCTTCGTAACAGCTGTACTGTAATCACAGACCTGGAGGAGCAGCTAAACCAGCTGACCGAGGACAACGCTGAACT
CAACAACCAAAACTTCTACTTGTCCAAACAACTCGATGAGGCTTCTGGCGCCAACGACGAGATTGTACAACTGCGAAGTGAAGTGGACCA
TCTCCGCCGGGAGATCACGGAACGAGAGATGCAGCTTACCAGCCAGAAGCAAACGATGGAGGCTCTGAAGACCACGTGCACCATGCTGGA
GGAACAGGTCATGGATTTGGAGGCCCTAAACGATGAGCTGCTAGAAAAAGAGCGGCAGTGGGAGGCCTGGAGGAGCGTCCTGGGTGATGA
GAAATCCCAGTTTGAGTGTCGGGTTCGAGAGCTGCAGAGAATGCTGGACACCGAGAAACAGAGCAGGGCGAGAGCCGATCAGCGGATCAC
CGAGTCTCGCCAGGTGGTGGAGCTGGCAGTGAAGGAGCACAAGGCTGAGATTCTCGCTCTGCAGCAGGCTCTCAAAGAGCAGAAGCTGAA
GGCCGAGAGCCTCTCTGACAAGCTCAATGACCTGGAGAAGAAGCATGCTATGCTTGAAATGAATGCCCGAAGCTTACAGCAGAAGCTGGA
GACTGAACGAGAGCTCAAACAGAGGCTTCTGGAAGAGCAAGCCAAATTACAGCAGCAGATGGACCTGCAGAAAAATCACATTTTCCGTCT
GACTCAAGGACTGCAAGAAGCTCTAGATCGGGCTGATCTACTGAAGACAGAAAGAAGTGACTTGGAGTATCAGCTGGAAAACATTCAGGT
TCTCTATTCTCATGAAAAGGTGAAAATGGAAGGCACTATTTCTCAACAAACCAAACTCATTGATTTTCTGCAAGCCAAAATGGACCAACC
TGCTAAAAAGAAAAAGGGTTTATTTAGTCGACGGAAAGAGGACCCTGCTTTACCCACACAGGTTCCTCTGCAGTACAATGAGCTGAAGCT
GGCCCTGGAGAAGGAGAAAGCTCGCTGTGCAGAGCTAGAGGAAGCCCTTCAGAAGACCCGCATCGAGCTCCGGTCCGCCCGGGAGGAAGC
TGCCCACCGCAAAGCAACGGACCACCCACACCCATCCACGCCAGCCACCGCGAGGCAGCAGATCGCCATGTCCGCCATCGTGCGGTCGCC
AGAGCACCAGCCCAGTGCCATGAGCCTGCTGGCCCCGCCATCCAGCCGCAGAAAGGAGTCTTCAACTCCAGAGGAATTTAGTCGGCGTCT
TAAGGAACGCATGCACCACAATATTCCTCACCGATTCAACGTAGGACTGAACATGCGAGCCACAAAGTGTGCTGTGTGTCTGGATACCGT
GCACTTTGGACGCCAGGCATCCAAATGTCTCGAATGTCAGGTGATGTGTCACCCCAAGTGCTCCACGTGCTTGCCAGCCACCTGCGGCTT
GCCTGCTGAATATGCCACACACTTCACCGAGGCCTTCTGCCGTGACAAAATGAACTCCCCAGGTCTCCAGACCAAGGAGCCCAGCAGCAG
CTTGCACCTGGAAGGGTGGATGAAGGTGCCCAGGAATAACAAACGAGGACAGCAAGGCTGGGACAGGAAGTACATTGTCCTGGAGGGATC
AAAAGTCCTCATTTATGACAATGAAGCCAGAGAAGCTGGACAGAGGCCGGTGGAAGAATTTGAGCTGTGCCTTCCCGACGGGGATGTATC
TATTCATGGTGCCGTTGGTGCTTCCGAACTCGCAAATACAGCCAAAGCAGATGTCCCATACATACTGAAGATGGAATCTCACCCGCACAC
CACCTGCTGGCCCGGGAGAACCCTCTACTTGCTAGCTCCCAGCTTCCCTGACAAACAGCGCTGGGTCACCGCCTTAGAATCAGTTGTCGC
AGGTGGGAGAGTTTCTAGGGAAAAAGCAGAAGCTGATGCTAAACTGCTTGGAAACTCCCTGCTGAAACTGGAAGGTGATGACCGTCTAGA
CATGAACTGCACGCTGCCCTTCAGTGACCAGGTGGTGTTGGTGGGCACCGAGGAAGGGCTCTACGCCCTGAATGTCTTGAAAAACTCCCT
AACCCATGTCCCAGGAATTGGAGCAGTCTTCCAAATTTATATTATCAAGGACCTGGAGAAGCTACTCATGATAGCAGGAGAAGAGCGGGC
ACTGTGTCTTGTGGACGTGAAGAAAGTGAAACAGTCCCTGGCCCAGTCCCACCTGCCTGCCCAGCCCGACATCTCACCCAACATTTTTGA
AGCTGTCAAGGGCTGCCACTTGTTTGGGGCAGGCAAGATTGAGAACGGGCTCTGCATCTGTGCAGCCATGCCCAGCAAAGTCGTCATTCT
CCGCTACAACGAAAACCTCAGCAAATACTGCATCCGGAAAGAGATAGAGACCTCAGAGCCCTGCAGCTGTATCCACTTCACCAATTACAG
TATCCTCATTGGAACCAATAAATTCTACGAAATCGACATGAAGCAGTACACGCTCGAGGAATTCCTGGATAAGAATGACCATTCCTTGGC
ACCTGCTGTGTTTGCCGCCTCTTCCAACAGCTTCCCTGTCTCAATCGTGCAGGTGAACAGCGCAGGGCAGCGAGAGGAGTACTTGCTGTG
TTTCCACGAATTTGGAGTGTTCGTGGATTCTTACGGAAGACGTAGCCGCACAGACGATCTCAAGTGGAGTCGCTTACCTTTGGCCTTTGC
CTACAGAGAACCCTATCTGTTTGTGACCCACTTCAACTCACTCGAAGTAATTGAGATCCAGGCACGCTCCTCAGCAGGGACCCCTGCCCG
AGCGTACCTGGACATCCCGAACCCGCGCTACCTGGGCCCTGCCATTTCCTCAGGAGCGATTTACTTGGCGTCCTCATACCAGGATAAATT
AAGGGTCATTTGCTGCAAGGGAAACCTCGTGAAGGAGTCCGGCACTGAACACCACCGGGGCCCGTCCACCTCCCGCAGCAGCCCCAACAA
GCGAGGCCCACCCACGTACAACGAGCACATCACCAAGCGCGTGGCCTCCAGCCCAGCGCCGCCCGAAGGCCCCAGCCACCCGCGAGAGCC
AAGCACACCCCACCGCTACCGCGAGGGGCGGACCGAGCTGCGCAGGGACAAGTCTCCTGGCCGCCCCCTGGAGCGAGAGAAGTCCCCCGG
CCGGATGCTCAGCACGCGGAGAGAGCGGTCCCCCGGGAGGCTGTTTGAAGACAGCAGCAGGGGCCGGCTGCCTGCGGGAGCCGTGAGGAC
CCCGCTGTCCCAGGTGAACAAGGTCTGGGACCAGTCTTCAGTATAAATCTCAGCCAGAAAAACCAACTCCTCATCTTGATCTGCAGGAAA
ACACCAAACACACTATGGAACTCTGCTGATGGGGACCCAAGCGCCCACGTGCTCAGCCACCCTCTGGCTCAGCGGGGCCCAGACCCACCT
CGGCACGGACACCCCTGTCTCCAGGAGGGGCAGGTGGCTGAGGCTCTTCGGAGCTGTCAGCGCCCGGTGCCTGCCCTGGGCACCTCCCTG
CAGTCATCTCTTTGCACTTTGTTACTCTTTCAAAGCATTCACAAACTTTTGTACCTAGCTCTAGCCTGTACCAGTTAGTTCATCAAAGGA
AACCAACCGGGATGCTAACTACAACATGGTTAGAATCCTAATTAGCTACTTTAAGATCCTAGGATTGGTTGGTTTTTCTTTTTTTTTTCT
CTTTGTTTCTTTCCTTTTTTTTTTTTTTTTTTTAAGACAACAGAATTCTTAATAGATTTGAATAGCGACGTATTTCCTGTTGTAGTCATT
TTTAGCTCGACCACATCATCAGGTCTTTGCCACCGAGGCATAGTGTAGAACAGTCCCGGTCAGTTGGCCAACCTCCCGCAGCCAAGTAGG
TTCATCCTTGTTCCTGTTCATTCTCATAGATGGCCCTGCTTTCCCCAGGGTGACATCGTAGCCAAATGTTTACTGTTTTCATTGCCTTTT
ATGGCCTTGACGACTTCCCCTCCCACCAGCTGAGAATGTATGGAGGTCATCGGGGCCTCAGCTCGGAGGCAGTGACTTGGGGCCAAGGGA
CCTCGAGACGCTTTCCTTCCCCACCCCCCAGCGTCATCTCCCCAGCCTGCTGTTCCCGCTTTCCATATAGCTTTGGCCAGGAAAGCATGC
AATAGACTTGCTCGGAGCCCAGCACTCCTGGGTCTCGGGGTCGGGGAGGGGACGGGGGCACCCACTTCCTTGTCTGTGACGGCGTGTTGT
TCCCCACTCTGGGATGGGGAAGAGGCCCGTCGGGAGTTCTGCATGGCAGTTCACTGCATGTGCTGCCCCCTTGGGTTGCTCTGCCAATGT
ATTAATACCATCCCATAGCTCCTGCCAAATCGAGACCCTCTGACGACTTGCCGACTAACTGGCCACCACAAGCTGCAGTCTGTAGCACTG
AACAAACAAAAAACAAAACGCTCAAGCCTTACGACCAGAGAAGGATTTCAGCAAACCACCACCTCCCACTCAGTGTCCCCTCCAAACTTC
ACACTTCCCTGCCTGCAGAGGATGACTCTGTTCACACCCAATCCAGCGCGGTTCTACCCCACGAAACTGTGACTTTCCAAATGAGCCTTT
CCCTAGGGCTAGACCTAAGACCAGGAAGTTTGAGAAAGCAGCCGCAGCTCAACTCTTCCAGCTCCGCCAGGGTTGGGAAGTCCTTAGGTG
CAGTGCGGCTCCCACTGGGTCTGCGGACCCTCCTATTAGAGTACGAAATTCCTGGCAACTGGTACAGAACCAACCTAGAGGCTTTGCAGT
TGGCAAGCTAACTCGCGGCCTTATTTCTGCCTTTAATCTCCCACAAGGCATCTGTTGCTTTGGGTCCTCCACGACTCTTAGGCCCGCCTC
AACAACCCAGGCACCTCCTAGGTAGGCTCAAAGGTAGACCCGTTTCCACCGCAGCAGGTGAACATGACCGTGTTTTCAACTGTGTCCACA
GTTCAGATCCCTTTCCAGATTGCAACCTGGCCTGCATCCCAGCTCCTTCCTGCTCGTGTCTTAACCTAAGTGCTTTCTTGTTTGAAACGC
CTACAAACCTCCATGTGGTAGCTCCTTTGGCAAATGTCCTGCTGTGGCGTTTTATGTGTTGCTTGGAGTCTGTGGGGTCGTACTCCCTCC
CCTCCCGTCCCCAGGGCAGATTTGATTGAATGTTTGCTGAAGTTTTGTCTCTTGGTCCACAGTATTTGGAAAGGTCACTGAAAATGGGTC
TTTCAGTCTTGGCATTTCATTTAGGATCTCCATGAGAAATGGGCTTCTTGAGCCCTGAAAATGTATATTGTGTGTCTCATCTGTGAACTG
CTTTCTGCTATATAGAACTAGCTCAAAAGACTGTACATATTTACAAGAAACTTTATATTCGTAAAAAAAAAAAGAGGAAATTGAATTGGT
TTCTACTTTTTTATTGTAAAAGGTGCATTTTTCAACACTTACTTTTGGTTTCAATGGTGGTAGTTGTGGACAGCCATCTTCACTGGAGGG
TGGGGAGCTCCGTGTGACCACCAAGATGCCAGCAGGATATACCGTAACACGAAATTGCTGTCAAAAGCTTATTAGCATCAATCAAGATTC
TAGGTCTCCAAAAGTACAGGCTTTTTCTTCATTACCTTTTTTATTCAGAACGAGGAAGAGAACACAAGGAATGATTCAAGATCCACCTTG

>5685_5685_5_APPL2-CIT_APPL2_chr12_105629737_ENST00000258530_CIT_chr12_120198859_ENST00000261833_length(amino acids)=1368AA_BP=67
MARRGRARGRRGHGVAAASPEPRAGECSRPPRLLPSVLPTQPSAEPRRTMPAVDKLLLEEALQDSPQVLDNQIKKDLADKETLENMMQRH
EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK
ISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR
DEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTC
TMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKE
QKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLE
NIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSA
REEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVC
LDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIV
LEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALE
SVVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAG
EERALCLVDVKKVKQSLAQSHLPAQPDISPNIFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHF
TNYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLP
LAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRS
SPNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELRRDKSPGRPLEREKSPGRMLSTRRERSPGRLFEDSSRGRLPAG

--------------------------------------------------------------
>5685_5685_6_APPL2-CIT_APPL2_chr12_105629737_ENST00000258530_CIT_chr12_120198859_ENST00000392521_length(transcript)=6628nt_BP=280nt
TTTCCCTGCCGGGCGCGCCACACTTCCTGTTGATCCGGCTCGGCCGGGGGCTGGGCCGGCGGGCAGGCGGCGGCGGCCACTGGCCAGGCG
TGGACGCGCGCGGGGCCGCCGCGGGCACGGAGTGGCCGCCGCGTCGCCTGAGCCCAGAGCCGGGGAGTGCTCTCGGCCGCCGCGTCTCCT
GCCCTCTGTCCTTCCAACCCAGCCCTCGGCTGAGCCGCGCCGCACCATGCCCGCCGTGGACAAGCTCCTGCTAGAGGAGGCGTTGCAGGA
CAGCCCCCAGGTGTTGGACAATCAGATAAAGAAAGACCTGGCTGACAAGGAGACACTGGAGAACATGATGCAGAGACACGAGGAGGAGGC
CCATGAGAAGGGCAAAATTCTCAGCGAACAGAAGGCGATGATCAATGCTATGGATTCCAAGATCAGATCCCTGGAACAGAGGATTGTGGA
ACTGTCTGAAGCCAATAAACTTGCAGCAAATAGCAGTCTTTTTACCCAAAGGAACATGAAGGCCCAAGAAGAGATGATTTCTGAACTCAG
GCAACAGAAATTTTACCTGGAGACACAGGCTGGGAAGTTGGAGGCCCAGAACCGAAAACTGGAGGAGCAGCTGGAGAAGATCAGCCACCA
AGACCACAGTGACAAGAATCGGCTGCTGGAACTGGAGACAAGATTGCGGGAGGTCAGTCTAGAGCACGAGGAGCAGAAACTGGAGCTCAA
GCGCCAGCTCACAGAGCTACAGCTCTCCCTGCAGGAGCGCGAGTCACAGTTGACAGCCCTGCAGGCTGCACGGGCGGCCCTGGAGAGCCA
GCTTCGCCAGGCGAAGACAGAGCTGGAAGAGACCACAGCAGAAGCTGAAGAGGAGATCCAGGCACTCACGGCACATAGAGATGAAATCCA
GCGCAAATTTGATGCTCTTCGTAACAGCTGTACTGTAATCACAGACCTGGAGGAGCAGCTAAACCAGCTGACCGAGGACAACGCTGAACT
CAACAACCAAAACTTCTACTTGTCCAAACAACTCGATGAGGCTTCTGGCGCCAACGACGAGATTGTACAACTGCGAAGTGAAGTGGACCA
TCTCCGCCGGGAGATCACGGAACGAGAGATGCAGCTTACCAGCCAGAAGCAAACGATGGAGGCTCTGAAGACCACGTGCACCATGCTGGA
GGAACAGGTCATGGATTTGGAGGCCCTAAACGATGAGCTGCTAGAAAAAGAGCGGCAGTGGGAGGCCTGGAGGAGCGTCCTGGGTGATGA
GAAATCCCAGTTTGAGTGTCGGGTTCGAGAGCTGCAGAGAATGCTGGACACCGAGAAACAGAGCAGGGCGAGAGCCGATCAGCGGATCAC
CGAGTCTCGCCAGGTGGTGGAGCTGGCAGTGAAGGAGCACAAGGCTGAGATTCTCGCTCTGCAGCAGGCTCTCAAAGAGCAGAAGCTGAA
GGCCGAGAGCCTCTCTGACAAGCTCAATGACCTGGAGAAGAAGCATGCTATGCTTGAAATGAATGCCCGAAGCTTACAGCAGAAGCTGGA
GACTGAACGAGAGCTCAAACAGAGGCTTCTGGAAGAGCAAGCCAAATTACAGCAGCAGATGGACCTGCAGAAAAATCACATTTTCCGTCT
GACTCAAGGACTGCAAGAAGCTCTAGATCGGGCTGATCTACTGAAGACAGAAAGAAGTGACTTGGAGTATCAGCTGGAAAACATTCAGGT
TCTCTATTCTCATGAAAAGGTGAAAATGGAAGGCACTATTTCTCAACAAACCAAACTCATTGATTTTCTGCAAGCCAAAATGGACCAACC
TGCTAAAAAGAAAAAGGGTTTATTTAGTCGACGGAAAGAGGACCCTGCTTTACCCACACAGGTTCCTCTGCAGTACAATGAGCTGAAGCT
GGCCCTGGAGAAGGAGAAAGCTCGCTGTGCAGAGCTAGAGGAAGCCCTTCAGAAGACCCGCATCGAGCTCCGGTCCGCCCGGGAGGAAGC
TGCCCACCGCAAAGCAACGGACCACCCACACCCATCCACGCCAGCCACCGCGAGGCAGCAGATCGCCATGTCCGCCATCGTGCGGTCGCC
AGAGCACCAGCCCAGTGCCATGAGCCTGCTGGCCCCGCCATCCAGCCGCAGAAAGGAGTCTTCAACTCCAGAGGAATTTAGTCGGCGTCT
TAAGGAACGCATGCACCACAATATTCCTCACCGATTCAACGTAGGACTGAACATGCGAGCCACAAAGTGTGCTGTGTGTCTGGATACCGT
GCACTTTGGACGCCAGGCATCCAAATGTCTCGAATGTCAGGTGATGTGTCACCCCAAGTGCTCCACGTGCTTGCCAGCCACCTGCGGCTT
GCCTGCTGAATATGCCACACACTTCACCGAGGCCTTCTGCCGTGACAAAATGAACTCCCCAGGTCTCCAGACCAAGGAGCCCAGCAGCAG
CTTGCACCTGGAAGGGTGGATGAAGGTGCCCAGGAATAACAAACGAGGACAGCAAGGCTGGGACAGGAAGTACATTGTCCTGGAGGGATC
AAAAGTCCTCATTTATGACAATGAAGCCAGAGAAGCTGGACAGAGGCCGGTGGAAGAATTTGAGCTGTGCCTTCCCGACGGGGATGTATC
TATTCATGGTGCCGTTGGTGCTTCCGAACTCGCAAATACAGCCAAAGCAGATGTCCCATACATACTGAAGATGGAATCTCACCCGCACAC
CACCTGCTGGCCCGGGAGAACCCTCTACTTGCTAGCTCCCAGCTTCCCTGACAAACAGCGCTGGGTCACCGCCTTAGAATCAGTTGTCGC
AGGTGGGAGAGTTTCTAGGGAAAAAGCAGAAGCTGATGCTAAACTGCTTGGAAACTCCCTGCTGAAACTGGAAGGTGATGACCGTCTAGA
CATGAACTGCACGCTGCCCTTCAGTGACCAGGTGGTGTTGGTGGGCACCGAGGAAGGGCTCTACGCCCTGAATGTCTTGAAAAACTCCCT
AACCCATGTCCCAGGAATTGGAGCAGTCTTCCAAATTTATATTATCAAGGACCTGGAGAAGCTACTCATGATAGCAGGAGAAGAGCGGGC
ACTGTGTCTTGTGGACGTGAAGAAAGTGAAACAGTCCCTGGCCCAGTCCCACCTGCCTGCCCAGCCCGACATCTCACCCAACATTTTTGA
AGCTGTCAAGGGCTGCCACTTGTTTGGGGCAGGCAAGATTGAGAACGGGCTCTGCATCTGTGCAGCCATGCCCAGCAAAGTCGTCATTCT
CCGCTACAACGAAAACCTCAGCAAATACTGCATCCGGAAAGAGATAGAGACCTCAGAGCCCTGCAGCTGTATCCACTTCACCAATTACAG
TATCCTCATTGGAACCAATAAATTCTACGAAATCGACATGAAGCAGTACACGCTCGAGGAATTCCTGGATAAGAATGACCATTCCTTGGC
ACCTGCTGTGTTTGCCGCCTCTTCCAACAGCTTCCCTGTCTCAATCGTGCAGGTGAACAGCGCAGGGCAGCGAGAGGAGTACTTGCTGTG
TTTCCACGAATTTGGAGTGTTCGTGGATTCTTACGGAAGACGTAGCCGCACAGACGATCTCAAGTGGAGTCGCTTACCTTTGGCCTTTGC
CTACAGAGAACCCTATCTGTTTGTGACCCACTTCAACTCACTCGAAGTAATTGAGATCCAGGCACGCTCCTCAGCAGGGACCCCTGCCCG
AGCGTACCTGGACATCCCGAACCCGCGCTACCTGGGCCCTGCCATTTCCTCAGGAGCGATTTACTTGGCGTCCTCATACCAGGATAAATT
AAGGGTCATTTGCTGCAAGGGAAACCTCGTGAAGGAGTCCGGCACTGAACACCACCGGGGCCCGTCCACCTCCCGCAGCAGCCCCAACAA
GCGAGGCCCACCCACGTACAACGAGCACATCACCAAGCGCGTGGCCTCCAGCCCAGCGCCGCCCGAAGGCCCCAGCCACCCGCGAGAGCC
AAGCACACCCCACCGCTACCGCGAGGGGCGGACCGAGCTGCGCAGGGACAAGTCTCCTGGCCGCCCCCTGGAGCGAGAGAAGTCCCCCGG
CCGGATGCTCAGCACGCGGAGAGAGCGGTCCCCCGGGAGGCTGTTTGAAGACAGCAGCAGGGGCCGGCTGCCTGCGGGAGCCGTGAGGAC
CCCGCTGTCCCAGGTGAACAAGGTCTGGGACCAGTCTTCAGTATAAATCTCAGCCAGAAAAACCAACTCCTCATCTTGATCTGCAGGAAA
ACACCAAACACACTATGGAACTCTGCTGATGGGGACCCAAGCGCCCACGTGCTCAGCCACCCTCTGGCTCAGCGGGGCCCAGACCCACCT
CGGCACGGACACCCCTGTCTCCAGGAGGGGCAGGTGGCTGAGGCTCTTCGGAGCTGTCAGCGCCCGGTGCCTGCCCTGGGCACCTCCCTG
CAGTCATCTCTTTGCACTTTGTTACTCTTTCAAAGCATTCACAAACTTTTGTACCTAGCTCTAGCCTGTACCAGTTAGTTCATCAAAGGA
AACCAACCGGGATGCTAACTACAACATGGTTAGAATCCTAATTAGCTACTTTAAGATCCTAGGATTGGTTGGTTTTTCTTTTTTTTTTCT
CTTTGTTTCTTTCCTTTTTTTTTTTTTTTTTTTAAGACAACAGAATTCTTAATAGATTTGAATAGCGACGTATTTCCTGTTGTAGTCATT
TTTAGCTCGACCACATCATCAGGTCTTTGCCACCGAGGCATAGTGTAGAACAGTCCCGGTCAGTTGGCCAACCTCCCGCAGCCAAGTAGG
TTCATCCTTGTTCCTGTTCATTCTCATAGATGGCCCTGCTTTCCCCAGGGTGACATCGTAGCCAAATGTTTACTGTTTTCATTGCCTTTT
ATGGCCTTGACGACTTCCCCTCCCACCAGCTGAGAATGTATGGAGGTCATCGGGGCCTCAGCTCGGAGGCAGTGACTTGGGGCCAAGGGA
CCTCGAGACGCTTTCCTTCCCCACCCCCCAGCGTCATCTCCCCAGCCTGCTGTTCCCGCTTTCCATATAGCTTTGGCCAGGAAAGCATGC
AATAGACTTGCTCGGAGCCCAGCACTCCTGGGTCTCGGGGTCGGGGAGGGGACGGGGGCACCCACTTCCTTGTCTGTGACGGCGTGTTGT
TCCCCACTCTGGGATGGGGAAGAGGCCCGTCGGGAGTTCTGCATGGCAGTTCACTGCATGTGCTGCCCCCTTGGGTTGCTCTGCCAATGT
ATTAATACCATCCCATAGCTCCTGCCAAATCGAGACCCTCTGACGACTTGCCGACTAACTGGCCACCACAAGCTGCAGTCTGTAGCACTG
AACAAACAAAAAACAAAACGCTCAAGCCTTACGACCAGAGAAGGATTTCAGCAAACCACCACCTCCCACTCAGTGTCCCCTCCAAACTTC
ACACTTCCCTGCCTGCAGAGGATGACTCTGTTCACACCCAATCCAGCGCGGTTCTACCCCACGAAACTGTGACTTTCCAAATGAGCCTTT
CCCTAGGGCTAGACCTAAGACCAGGAAGTTTGAGAAAGCAGCCGCAGCTCAACTCTTCCAGCTCCGCCAGGGTTGGGAAGTCCTTAGGTG
CAGTGCGGCTCCCACTGGGTCTGCGGACCCTCCTATTAGAGTACGAAATTCCTGGCAACTGGTACAGAACCAACCTAGAGGCTTTGCAGT
TGGCAAGCTAACTCGCGGCCTTATTTCTGCCTTTAATCTCCCACAAGGCATCTGTTGCTTTGGGTCCTCCACGACTCTTAGGCCCGCCTC
AACAACCCAGGCACCTCCTAGGTAGGCTCAAAGGTAGACCCGTTTCCACCGCAGCAGGTGAACATGACCGTGTTTTCAACTGTGTCCACA
GTTCAGATCCCTTTCCAGATTGCAACCTGGCCTGCATCCCAGCTCCTTCCTGCTCGTGTCTTAACCTAAGTGCTTTCTTGTTTGAAACGC
CTACAAACCTCCATGTGGTAGCTCCTTTGGCAAATGTCCTGCTGTGGCGTTTTATGTGTTGCTTGGAGTCTGTGGGGTCGTACTCCCTCC
CCTCCCGTCCCCAGGGCAGATTTGATTGAATGTTTGCTGAAGTTTTGTCTCTTGGTCCACAGTATTTGGAAAGGTCACTGAAAATGGGTC
TTTCAGTCTTGGCATTTCATTTAGGATCTCCATGAGAAATGGGCTTCTTGAGCCCTGAAAATGTATATTGTGTGTCTCATCTGTGAACTG
CTTTCTGCTATATAGAACTAGCTCAAAAGACTGTACATATTTACAAGAAACTTTATATTCGTAAAAAAAAAAAGAGGAAATTGAATTGGT
TTCTACTTTTTTATTGTAAAAGGTGCATTTTTCAACACTTACTTTTGGTTTCAATGGTGGTAGTTGTGGACAGCCATCTTCACTGGAGGG
TGGGGAGCTCCGTGTGACCACCAAGATGCCAGCAGGATATACCGTAACACGAAATTGCTGTCAAAAGCTTATTAGCATCAATCAAGATTC
TAGGTCTCCAAAAGTACAGGCTTTTTCTTCATTACCTTTTTTATTCAGAACGAGGAAGAGAACACAAGGAATGATTCAAGATCCACCTTG

>5685_5685_6_APPL2-CIT_APPL2_chr12_105629737_ENST00000258530_CIT_chr12_120198859_ENST00000392521_length(amino acids)=1368AA_BP=67
MARRGRARGRRGHGVAAASPEPRAGECSRPPRLLPSVLPTQPSAEPRRTMPAVDKLLLEEALQDSPQVLDNQIKKDLADKETLENMMQRH
EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK
ISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR
DEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTC
TMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKE
QKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLE
NIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSA
REEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVC
LDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIV
LEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALE
SVVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAG
EERALCLVDVKKVKQSLAQSHLPAQPDISPNIFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHF
TNYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLP
LAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRS
SPNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELRRDKSPGRPLEREKSPGRMLSTRRERSPGRLFEDSSRGRLPAG

--------------------------------------------------------------
>5685_5685_7_APPL2-CIT_APPL2_chr12_105629737_ENST00000551662_CIT_chr12_120198859_ENST00000261833_length(transcript)=6472nt_BP=125nt
AGTGCTCTCGGCCGCCGCGTCTCCTGCCCTCTGTCCTTCCAACCCAGCCCTCGGCTGAGCCGCGCCGCACCATGCCCGCCGTGGACAAGC
TCCTGCTAGAGGAGGCGTTGCAGGACAGCCCCCAGGTGTTGGACAATCAGATAAAGAAAGACCTGGCTGACAAGGAGACACTGGAGAACA
TGATGCAGAGACACGAGGAGGAGGCCCATGAGAAGGGCAAAATTCTCAGCGAACAGAAGGCGATGATCAATGCTATGGATTCCAAGATCA
GATCCCTGGAACAGAGGATTGTGGAACTGTCTGAAGCCAATAAACTTGCAGCAAATAGCAGTCTTTTTACCCAAAGGAACATGAAGGCCC
AAGAAGAGATGATTTCTGAACTCAGGCAACAGAAATTTTACCTGGAGACACAGGCTGGGAAGTTGGAGGCCCAGAACCGAAAACTGGAGG
AGCAGCTGGAGAAGATCAGCCACCAAGACCACAGTGACAAGAATCGGCTGCTGGAACTGGAGACAAGATTGCGGGAGGTCAGTCTAGAGC
ACGAGGAGCAGAAACTGGAGCTCAAGCGCCAGCTCACAGAGCTACAGCTCTCCCTGCAGGAGCGCGAGTCACAGTTGACAGCCCTGCAGG
CTGCACGGGCGGCCCTGGAGAGCCAGCTTCGCCAGGCGAAGACAGAGCTGGAAGAGACCACAGCAGAAGCTGAAGAGGAGATCCAGGCAC
TCACGGCACATAGAGATGAAATCCAGCGCAAATTTGATGCTCTTCGTAACAGCTGTACTGTAATCACAGACCTGGAGGAGCAGCTAAACC
AGCTGACCGAGGACAACGCTGAACTCAACAACCAAAACTTCTACTTGTCCAAACAACTCGATGAGGCTTCTGGCGCCAACGACGAGATTG
TACAACTGCGAAGTGAAGTGGACCATCTCCGCCGGGAGATCACGGAACGAGAGATGCAGCTTACCAGCCAGAAGCAAACGATGGAGGCTC
TGAAGACCACGTGCACCATGCTGGAGGAACAGGTCATGGATTTGGAGGCCCTAAACGATGAGCTGCTAGAAAAAGAGCGGCAGTGGGAGG
CCTGGAGGAGCGTCCTGGGTGATGAGAAATCCCAGTTTGAGTGTCGGGTTCGAGAGCTGCAGAGAATGCTGGACACCGAGAAACAGAGCA
GGGCGAGAGCCGATCAGCGGATCACCGAGTCTCGCCAGGTGGTGGAGCTGGCAGTGAAGGAGCACAAGGCTGAGATTCTCGCTCTGCAGC
AGGCTCTCAAAGAGCAGAAGCTGAAGGCCGAGAGCCTCTCTGACAAGCTCAATGACCTGGAGAAGAAGCATGCTATGCTTGAAATGAATG
CCCGAAGCTTACAGCAGAAGCTGGAGACTGAACGAGAGCTCAAACAGAGGCTTCTGGAAGAGCAAGCCAAATTACAGCAGCAGATGGACC
TGCAGAAAAATCACATTTTCCGTCTGACTCAAGGACTGCAAGAAGCTCTAGATCGGGCTGATCTACTGAAGACAGAAAGAAGTGACTTGG
AGTATCAGCTGGAAAACATTCAGGTTCTCTATTCTCATGAAAAGGTGAAAATGGAAGGCACTATTTCTCAACAAACCAAACTCATTGATT
TTCTGCAAGCCAAAATGGACCAACCTGCTAAAAAGAAAAAGGGTTTATTTAGTCGACGGAAAGAGGACCCTGCTTTACCCACACAGGTTC
CTCTGCAGTACAATGAGCTGAAGCTGGCCCTGGAGAAGGAGAAAGCTCGCTGTGCAGAGCTAGAGGAAGCCCTTCAGAAGACCCGCATCG
AGCTCCGGTCCGCCCGGGAGGAAGCTGCCCACCGCAAAGCAACGGACCACCCACACCCATCCACGCCAGCCACCGCGAGGCAGCAGATCG
CCATGTCCGCCATCGTGCGGTCGCCAGAGCACCAGCCCAGTGCCATGAGCCTGCTGGCCCCGCCATCCAGCCGCAGAAAGGAGTCTTCAA
CTCCAGAGGAATTTAGTCGGCGTCTTAAGGAACGCATGCACCACAATATTCCTCACCGATTCAACGTAGGACTGAACATGCGAGCCACAA
AGTGTGCTGTGTGTCTGGATACCGTGCACTTTGGACGCCAGGCATCCAAATGTCTCGAATGTCAGGTGATGTGTCACCCCAAGTGCTCCA
CGTGCTTGCCAGCCACCTGCGGCTTGCCTGCTGAATATGCCACACACTTCACCGAGGCCTTCTGCCGTGACAAAATGAACTCCCCAGGTC
TCCAGACCAAGGAGCCCAGCAGCAGCTTGCACCTGGAAGGGTGGATGAAGGTGCCCAGGAATAACAAACGAGGACAGCAAGGCTGGGACA
GGAAGTACATTGTCCTGGAGGGATCAAAAGTCCTCATTTATGACAATGAAGCCAGAGAAGCTGGACAGAGGCCGGTGGAAGAATTTGAGC
TGTGCCTTCCCGACGGGGATGTATCTATTCATGGTGCCGTTGGTGCTTCCGAACTCGCAAATACAGCCAAAGCAGATGTCCCATACATAC
TGAAGATGGAATCTCACCCGCACACCACCTGCTGGCCCGGGAGAACCCTCTACTTGCTAGCTCCCAGCTTCCCTGACAAACAGCGCTGGG
TCACCGCCTTAGAATCAGTTGTCGCAGGTGGGAGAGTTTCTAGGGAAAAAGCAGAAGCTGATGCTAAACTGCTTGGAAACTCCCTGCTGA
AACTGGAAGGTGATGACCGTCTAGACATGAACTGCACGCTGCCCTTCAGTGACCAGGTGGTGTTGGTGGGCACCGAGGAAGGGCTCTACG
CCCTGAATGTCTTGAAAAACTCCCTAACCCATGTCCCAGGAATTGGAGCAGTCTTCCAAATTTATATTATCAAGGACCTGGAGAAGCTAC
TCATGATAGCAGGAGAAGAGCGGGCACTGTGTCTTGTGGACGTGAAGAAAGTGAAACAGTCCCTGGCCCAGTCCCACCTGCCTGCCCAGC
CCGACATCTCACCCAACATTTTTGAAGCTGTCAAGGGCTGCCACTTGTTTGGGGCAGGCAAGATTGAGAACGGGCTCTGCATCTGTGCAG
CCATGCCCAGCAAAGTCGTCATTCTCCGCTACAACGAAAACCTCAGCAAATACTGCATCCGGAAAGAGATAGAGACCTCAGAGCCCTGCA
GCTGTATCCACTTCACCAATTACAGTATCCTCATTGGAACCAATAAATTCTACGAAATCGACATGAAGCAGTACACGCTCGAGGAATTCC
TGGATAAGAATGACCATTCCTTGGCACCTGCTGTGTTTGCCGCCTCTTCCAACAGCTTCCCTGTCTCAATCGTGCAGGTGAACAGCGCAG
GGCAGCGAGAGGAGTACTTGCTGTGTTTCCACGAATTTGGAGTGTTCGTGGATTCTTACGGAAGACGTAGCCGCACAGACGATCTCAAGT
GGAGTCGCTTACCTTTGGCCTTTGCCTACAGAGAACCCTATCTGTTTGTGACCCACTTCAACTCACTCGAAGTAATTGAGATCCAGGCAC
GCTCCTCAGCAGGGACCCCTGCCCGAGCGTACCTGGACATCCCGAACCCGCGCTACCTGGGCCCTGCCATTTCCTCAGGAGCGATTTACT
TGGCGTCCTCATACCAGGATAAATTAAGGGTCATTTGCTGCAAGGGAAACCTCGTGAAGGAGTCCGGCACTGAACACCACCGGGGCCCGT
CCACCTCCCGCAGCAGCCCCAACAAGCGAGGCCCACCCACGTACAACGAGCACATCACCAAGCGCGTGGCCTCCAGCCCAGCGCCGCCCG
AAGGCCCCAGCCACCCGCGAGAGCCAAGCACACCCCACCGCTACCGCGAGGGGCGGACCGAGCTGCGCAGGGACAAGTCTCCTGGCCGCC
CCCTGGAGCGAGAGAAGTCCCCCGGCCGGATGCTCAGCACGCGGAGAGAGCGGTCCCCCGGGAGGCTGTTTGAAGACAGCAGCAGGGGCC
GGCTGCCTGCGGGAGCCGTGAGGACCCCGCTGTCCCAGGTGAACAAGGTCTGGGACCAGTCTTCAGTATAAATCTCAGCCAGAAAAACCA
ACTCCTCATCTTGATCTGCAGGAAAACACCAAACACACTATGGAACTCTGCTGATGGGGACCCAAGCGCCCACGTGCTCAGCCACCCTCT
GGCTCAGCGGGGCCCAGACCCACCTCGGCACGGACACCCCTGTCTCCAGGAGGGGCAGGTGGCTGAGGCTCTTCGGAGCTGTCAGCGCCC
GGTGCCTGCCCTGGGCACCTCCCTGCAGTCATCTCTTTGCACTTTGTTACTCTTTCAAAGCATTCACAAACTTTTGTACCTAGCTCTAGC
CTGTACCAGTTAGTTCATCAAAGGAAACCAACCGGGATGCTAACTACAACATGGTTAGAATCCTAATTAGCTACTTTAAGATCCTAGGAT
TGGTTGGTTTTTCTTTTTTTTTTCTCTTTGTTTCTTTCCTTTTTTTTTTTTTTTTTTTAAGACAACAGAATTCTTAATAGATTTGAATAG
CGACGTATTTCCTGTTGTAGTCATTTTTAGCTCGACCACATCATCAGGTCTTTGCCACCGAGGCATAGTGTAGAACAGTCCCGGTCAGTT
GGCCAACCTCCCGCAGCCAAGTAGGTTCATCCTTGTTCCTGTTCATTCTCATAGATGGCCCTGCTTTCCCCAGGGTGACATCGTAGCCAA
ATGTTTACTGTTTTCATTGCCTTTTATGGCCTTGACGACTTCCCCTCCCACCAGCTGAGAATGTATGGAGGTCATCGGGGCCTCAGCTCG
GAGGCAGTGACTTGGGGCCAAGGGACCTCGAGACGCTTTCCTTCCCCACCCCCCAGCGTCATCTCCCCAGCCTGCTGTTCCCGCTTTCCA
TATAGCTTTGGCCAGGAAAGCATGCAATAGACTTGCTCGGAGCCCAGCACTCCTGGGTCTCGGGGTCGGGGAGGGGACGGGGGCACCCAC
TTCCTTGTCTGTGACGGCGTGTTGTTCCCCACTCTGGGATGGGGAAGAGGCCCGTCGGGAGTTCTGCATGGCAGTTCACTGCATGTGCTG
CCCCCTTGGGTTGCTCTGCCAATGTATTAATACCATCCCATAGCTCCTGCCAAATCGAGACCCTCTGACGACTTGCCGACTAACTGGCCA
CCACAAGCTGCAGTCTGTAGCACTGAACAAACAAAAAACAAAACGCTCAAGCCTTACGACCAGAGAAGGATTTCAGCAAACCACCACCTC
CCACTCAGTGTCCCCTCCAAACTTCACACTTCCCTGCCTGCAGAGGATGACTCTGTTCACACCCAATCCAGCGCGGTTCTACCCCACGAA
ACTGTGACTTTCCAAATGAGCCTTTCCCTAGGGCTAGACCTAAGACCAGGAAGTTTGAGAAAGCAGCCGCAGCTCAACTCTTCCAGCTCC
GCCAGGGTTGGGAAGTCCTTAGGTGCAGTGCGGCTCCCACTGGGTCTGCGGACCCTCCTATTAGAGTACGAAATTCCTGGCAACTGGTAC
AGAACCAACCTAGAGGCTTTGCAGTTGGCAAGCTAACTCGCGGCCTTATTTCTGCCTTTAATCTCCCACAAGGCATCTGTTGCTTTGGGT
CCTCCACGACTCTTAGGCCCGCCTCAACAACCCAGGCACCTCCTAGGTAGGCTCAAAGGTAGACCCGTTTCCACCGCAGCAGGTGAACAT
GACCGTGTTTTCAACTGTGTCCACAGTTCAGATCCCTTTCCAGATTGCAACCTGGCCTGCATCCCAGCTCCTTCCTGCTCGTGTCTTAAC
CTAAGTGCTTTCTTGTTTGAAACGCCTACAAACCTCCATGTGGTAGCTCCTTTGGCAAATGTCCTGCTGTGGCGTTTTATGTGTTGCTTG
GAGTCTGTGGGGTCGTACTCCCTCCCCTCCCGTCCCCAGGGCAGATTTGATTGAATGTTTGCTGAAGTTTTGTCTCTTGGTCCACAGTAT
TTGGAAAGGTCACTGAAAATGGGTCTTTCAGTCTTGGCATTTCATTTAGGATCTCCATGAGAAATGGGCTTCTTGAGCCCTGAAAATGTA
TATTGTGTGTCTCATCTGTGAACTGCTTTCTGCTATATAGAACTAGCTCAAAAGACTGTACATATTTACAAGAAACTTTATATTCGTAAA
AAAAAAAAGAGGAAATTGAATTGGTTTCTACTTTTTTATTGTAAAAGGTGCATTTTTCAACACTTACTTTTGGTTTCAATGGTGGTAGTT
GTGGACAGCCATCTTCACTGGAGGGTGGGGAGCTCCGTGTGACCACCAAGATGCCAGCAGGATATACCGTAACACGAAATTGCTGTCAAA
AGCTTATTAGCATCAATCAAGATTCTAGGTCTCCAAAAGTACAGGCTTTTTCTTCATTACCTTTTTTATTCAGAACGAGGAAGAGAACAC

>5685_5685_7_APPL2-CIT_APPL2_chr12_105629737_ENST00000551662_CIT_chr12_120198859_ENST00000261833_length(amino acids)=1335AA_BP=34
MPSVLPTQPSAEPRRTMPAVDKLLLEEALQDSPQVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIV
ELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLEL
KRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAE
LNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGD
EKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL
ETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQ
PAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRS
PEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCG
LPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDV
SIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAKLLGNSLLKLEGDDRL
DMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPNIF
EAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQYTLEEFLDKNDHSL
APAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPA
RAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSSPNKRGPPTYNEHITKRVASSPAPPEGPSHPRE

--------------------------------------------------------------
>5685_5685_8_APPL2-CIT_APPL2_chr12_105629737_ENST00000551662_CIT_chr12_120198859_ENST00000392521_length(transcript)=6473nt_BP=125nt
AGTGCTCTCGGCCGCCGCGTCTCCTGCCCTCTGTCCTTCCAACCCAGCCCTCGGCTGAGCCGCGCCGCACCATGCCCGCCGTGGACAAGC
TCCTGCTAGAGGAGGCGTTGCAGGACAGCCCCCAGGTGTTGGACAATCAGATAAAGAAAGACCTGGCTGACAAGGAGACACTGGAGAACA
TGATGCAGAGACACGAGGAGGAGGCCCATGAGAAGGGCAAAATTCTCAGCGAACAGAAGGCGATGATCAATGCTATGGATTCCAAGATCA
GATCCCTGGAACAGAGGATTGTGGAACTGTCTGAAGCCAATAAACTTGCAGCAAATAGCAGTCTTTTTACCCAAAGGAACATGAAGGCCC
AAGAAGAGATGATTTCTGAACTCAGGCAACAGAAATTTTACCTGGAGACACAGGCTGGGAAGTTGGAGGCCCAGAACCGAAAACTGGAGG
AGCAGCTGGAGAAGATCAGCCACCAAGACCACAGTGACAAGAATCGGCTGCTGGAACTGGAGACAAGATTGCGGGAGGTCAGTCTAGAGC
ACGAGGAGCAGAAACTGGAGCTCAAGCGCCAGCTCACAGAGCTACAGCTCTCCCTGCAGGAGCGCGAGTCACAGTTGACAGCCCTGCAGG
CTGCACGGGCGGCCCTGGAGAGCCAGCTTCGCCAGGCGAAGACAGAGCTGGAAGAGACCACAGCAGAAGCTGAAGAGGAGATCCAGGCAC
TCACGGCACATAGAGATGAAATCCAGCGCAAATTTGATGCTCTTCGTAACAGCTGTACTGTAATCACAGACCTGGAGGAGCAGCTAAACC
AGCTGACCGAGGACAACGCTGAACTCAACAACCAAAACTTCTACTTGTCCAAACAACTCGATGAGGCTTCTGGCGCCAACGACGAGATTG
TACAACTGCGAAGTGAAGTGGACCATCTCCGCCGGGAGATCACGGAACGAGAGATGCAGCTTACCAGCCAGAAGCAAACGATGGAGGCTC
TGAAGACCACGTGCACCATGCTGGAGGAACAGGTCATGGATTTGGAGGCCCTAAACGATGAGCTGCTAGAAAAAGAGCGGCAGTGGGAGG
CCTGGAGGAGCGTCCTGGGTGATGAGAAATCCCAGTTTGAGTGTCGGGTTCGAGAGCTGCAGAGAATGCTGGACACCGAGAAACAGAGCA
GGGCGAGAGCCGATCAGCGGATCACCGAGTCTCGCCAGGTGGTGGAGCTGGCAGTGAAGGAGCACAAGGCTGAGATTCTCGCTCTGCAGC
AGGCTCTCAAAGAGCAGAAGCTGAAGGCCGAGAGCCTCTCTGACAAGCTCAATGACCTGGAGAAGAAGCATGCTATGCTTGAAATGAATG
CCCGAAGCTTACAGCAGAAGCTGGAGACTGAACGAGAGCTCAAACAGAGGCTTCTGGAAGAGCAAGCCAAATTACAGCAGCAGATGGACC
TGCAGAAAAATCACATTTTCCGTCTGACTCAAGGACTGCAAGAAGCTCTAGATCGGGCTGATCTACTGAAGACAGAAAGAAGTGACTTGG
AGTATCAGCTGGAAAACATTCAGGTTCTCTATTCTCATGAAAAGGTGAAAATGGAAGGCACTATTTCTCAACAAACCAAACTCATTGATT
TTCTGCAAGCCAAAATGGACCAACCTGCTAAAAAGAAAAAGGGTTTATTTAGTCGACGGAAAGAGGACCCTGCTTTACCCACACAGGTTC
CTCTGCAGTACAATGAGCTGAAGCTGGCCCTGGAGAAGGAGAAAGCTCGCTGTGCAGAGCTAGAGGAAGCCCTTCAGAAGACCCGCATCG
AGCTCCGGTCCGCCCGGGAGGAAGCTGCCCACCGCAAAGCAACGGACCACCCACACCCATCCACGCCAGCCACCGCGAGGCAGCAGATCG
CCATGTCCGCCATCGTGCGGTCGCCAGAGCACCAGCCCAGTGCCATGAGCCTGCTGGCCCCGCCATCCAGCCGCAGAAAGGAGTCTTCAA
CTCCAGAGGAATTTAGTCGGCGTCTTAAGGAACGCATGCACCACAATATTCCTCACCGATTCAACGTAGGACTGAACATGCGAGCCACAA
AGTGTGCTGTGTGTCTGGATACCGTGCACTTTGGACGCCAGGCATCCAAATGTCTCGAATGTCAGGTGATGTGTCACCCCAAGTGCTCCA
CGTGCTTGCCAGCCACCTGCGGCTTGCCTGCTGAATATGCCACACACTTCACCGAGGCCTTCTGCCGTGACAAAATGAACTCCCCAGGTC
TCCAGACCAAGGAGCCCAGCAGCAGCTTGCACCTGGAAGGGTGGATGAAGGTGCCCAGGAATAACAAACGAGGACAGCAAGGCTGGGACA
GGAAGTACATTGTCCTGGAGGGATCAAAAGTCCTCATTTATGACAATGAAGCCAGAGAAGCTGGACAGAGGCCGGTGGAAGAATTTGAGC
TGTGCCTTCCCGACGGGGATGTATCTATTCATGGTGCCGTTGGTGCTTCCGAACTCGCAAATACAGCCAAAGCAGATGTCCCATACATAC
TGAAGATGGAATCTCACCCGCACACCACCTGCTGGCCCGGGAGAACCCTCTACTTGCTAGCTCCCAGCTTCCCTGACAAACAGCGCTGGG
TCACCGCCTTAGAATCAGTTGTCGCAGGTGGGAGAGTTTCTAGGGAAAAAGCAGAAGCTGATGCTAAACTGCTTGGAAACTCCCTGCTGA
AACTGGAAGGTGATGACCGTCTAGACATGAACTGCACGCTGCCCTTCAGTGACCAGGTGGTGTTGGTGGGCACCGAGGAAGGGCTCTACG
CCCTGAATGTCTTGAAAAACTCCCTAACCCATGTCCCAGGAATTGGAGCAGTCTTCCAAATTTATATTATCAAGGACCTGGAGAAGCTAC
TCATGATAGCAGGAGAAGAGCGGGCACTGTGTCTTGTGGACGTGAAGAAAGTGAAACAGTCCCTGGCCCAGTCCCACCTGCCTGCCCAGC
CCGACATCTCACCCAACATTTTTGAAGCTGTCAAGGGCTGCCACTTGTTTGGGGCAGGCAAGATTGAGAACGGGCTCTGCATCTGTGCAG
CCATGCCCAGCAAAGTCGTCATTCTCCGCTACAACGAAAACCTCAGCAAATACTGCATCCGGAAAGAGATAGAGACCTCAGAGCCCTGCA
GCTGTATCCACTTCACCAATTACAGTATCCTCATTGGAACCAATAAATTCTACGAAATCGACATGAAGCAGTACACGCTCGAGGAATTCC
TGGATAAGAATGACCATTCCTTGGCACCTGCTGTGTTTGCCGCCTCTTCCAACAGCTTCCCTGTCTCAATCGTGCAGGTGAACAGCGCAG
GGCAGCGAGAGGAGTACTTGCTGTGTTTCCACGAATTTGGAGTGTTCGTGGATTCTTACGGAAGACGTAGCCGCACAGACGATCTCAAGT
GGAGTCGCTTACCTTTGGCCTTTGCCTACAGAGAACCCTATCTGTTTGTGACCCACTTCAACTCACTCGAAGTAATTGAGATCCAGGCAC
GCTCCTCAGCAGGGACCCCTGCCCGAGCGTACCTGGACATCCCGAACCCGCGCTACCTGGGCCCTGCCATTTCCTCAGGAGCGATTTACT
TGGCGTCCTCATACCAGGATAAATTAAGGGTCATTTGCTGCAAGGGAAACCTCGTGAAGGAGTCCGGCACTGAACACCACCGGGGCCCGT
CCACCTCCCGCAGCAGCCCCAACAAGCGAGGCCCACCCACGTACAACGAGCACATCACCAAGCGCGTGGCCTCCAGCCCAGCGCCGCCCG
AAGGCCCCAGCCACCCGCGAGAGCCAAGCACACCCCACCGCTACCGCGAGGGGCGGACCGAGCTGCGCAGGGACAAGTCTCCTGGCCGCC
CCCTGGAGCGAGAGAAGTCCCCCGGCCGGATGCTCAGCACGCGGAGAGAGCGGTCCCCCGGGAGGCTGTTTGAAGACAGCAGCAGGGGCC
GGCTGCCTGCGGGAGCCGTGAGGACCCCGCTGTCCCAGGTGAACAAGGTCTGGGACCAGTCTTCAGTATAAATCTCAGCCAGAAAAACCA
ACTCCTCATCTTGATCTGCAGGAAAACACCAAACACACTATGGAACTCTGCTGATGGGGACCCAAGCGCCCACGTGCTCAGCCACCCTCT
GGCTCAGCGGGGCCCAGACCCACCTCGGCACGGACACCCCTGTCTCCAGGAGGGGCAGGTGGCTGAGGCTCTTCGGAGCTGTCAGCGCCC
GGTGCCTGCCCTGGGCACCTCCCTGCAGTCATCTCTTTGCACTTTGTTACTCTTTCAAAGCATTCACAAACTTTTGTACCTAGCTCTAGC
CTGTACCAGTTAGTTCATCAAAGGAAACCAACCGGGATGCTAACTACAACATGGTTAGAATCCTAATTAGCTACTTTAAGATCCTAGGAT
TGGTTGGTTTTTCTTTTTTTTTTCTCTTTGTTTCTTTCCTTTTTTTTTTTTTTTTTTTAAGACAACAGAATTCTTAATAGATTTGAATAG
CGACGTATTTCCTGTTGTAGTCATTTTTAGCTCGACCACATCATCAGGTCTTTGCCACCGAGGCATAGTGTAGAACAGTCCCGGTCAGTT
GGCCAACCTCCCGCAGCCAAGTAGGTTCATCCTTGTTCCTGTTCATTCTCATAGATGGCCCTGCTTTCCCCAGGGTGACATCGTAGCCAA
ATGTTTACTGTTTTCATTGCCTTTTATGGCCTTGACGACTTCCCCTCCCACCAGCTGAGAATGTATGGAGGTCATCGGGGCCTCAGCTCG
GAGGCAGTGACTTGGGGCCAAGGGACCTCGAGACGCTTTCCTTCCCCACCCCCCAGCGTCATCTCCCCAGCCTGCTGTTCCCGCTTTCCA
TATAGCTTTGGCCAGGAAAGCATGCAATAGACTTGCTCGGAGCCCAGCACTCCTGGGTCTCGGGGTCGGGGAGGGGACGGGGGCACCCAC
TTCCTTGTCTGTGACGGCGTGTTGTTCCCCACTCTGGGATGGGGAAGAGGCCCGTCGGGAGTTCTGCATGGCAGTTCACTGCATGTGCTG
CCCCCTTGGGTTGCTCTGCCAATGTATTAATACCATCCCATAGCTCCTGCCAAATCGAGACCCTCTGACGACTTGCCGACTAACTGGCCA
CCACAAGCTGCAGTCTGTAGCACTGAACAAACAAAAAACAAAACGCTCAAGCCTTACGACCAGAGAAGGATTTCAGCAAACCACCACCTC
CCACTCAGTGTCCCCTCCAAACTTCACACTTCCCTGCCTGCAGAGGATGACTCTGTTCACACCCAATCCAGCGCGGTTCTACCCCACGAA
ACTGTGACTTTCCAAATGAGCCTTTCCCTAGGGCTAGACCTAAGACCAGGAAGTTTGAGAAAGCAGCCGCAGCTCAACTCTTCCAGCTCC
GCCAGGGTTGGGAAGTCCTTAGGTGCAGTGCGGCTCCCACTGGGTCTGCGGACCCTCCTATTAGAGTACGAAATTCCTGGCAACTGGTAC
AGAACCAACCTAGAGGCTTTGCAGTTGGCAAGCTAACTCGCGGCCTTATTTCTGCCTTTAATCTCCCACAAGGCATCTGTTGCTTTGGGT
CCTCCACGACTCTTAGGCCCGCCTCAACAACCCAGGCACCTCCTAGGTAGGCTCAAAGGTAGACCCGTTTCCACCGCAGCAGGTGAACAT
GACCGTGTTTTCAACTGTGTCCACAGTTCAGATCCCTTTCCAGATTGCAACCTGGCCTGCATCCCAGCTCCTTCCTGCTCGTGTCTTAAC
CTAAGTGCTTTCTTGTTTGAAACGCCTACAAACCTCCATGTGGTAGCTCCTTTGGCAAATGTCCTGCTGTGGCGTTTTATGTGTTGCTTG
GAGTCTGTGGGGTCGTACTCCCTCCCCTCCCGTCCCCAGGGCAGATTTGATTGAATGTTTGCTGAAGTTTTGTCTCTTGGTCCACAGTAT
TTGGAAAGGTCACTGAAAATGGGTCTTTCAGTCTTGGCATTTCATTTAGGATCTCCATGAGAAATGGGCTTCTTGAGCCCTGAAAATGTA
TATTGTGTGTCTCATCTGTGAACTGCTTTCTGCTATATAGAACTAGCTCAAAAGACTGTACATATTTACAAGAAACTTTATATTCGTAAA
AAAAAAAAGAGGAAATTGAATTGGTTTCTACTTTTTTATTGTAAAAGGTGCATTTTTCAACACTTACTTTTGGTTTCAATGGTGGTAGTT
GTGGACAGCCATCTTCACTGGAGGGTGGGGAGCTCCGTGTGACCACCAAGATGCCAGCAGGATATACCGTAACACGAAATTGCTGTCAAA
AGCTTATTAGCATCAATCAAGATTCTAGGTCTCCAAAAGTACAGGCTTTTTCTTCATTACCTTTTTTATTCAGAACGAGGAAGAGAACAC

>5685_5685_8_APPL2-CIT_APPL2_chr12_105629737_ENST00000551662_CIT_chr12_120198859_ENST00000392521_length(amino acids)=1335AA_BP=34
MPSVLPTQPSAEPRRTMPAVDKLLLEEALQDSPQVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIV
ELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLEL
KRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAE
LNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGD
EKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL
ETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQ
PAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRS
PEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCG
LPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDV
SIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAKLLGNSLLKLEGDDRL
DMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPNIF
EAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQYTLEEFLDKNDHSL
APAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPA
RAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSSPNKRGPPTYNEHITKRVASSPAPPEGPSHPRE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for APPL2-CIT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCITchr12:105629736chr12:120198859ENST0000026183317471091_1302726.02028.0Rho/Rac
TgeneCITchr12:105629736chr12:120198859ENST0000039252118481091_1302768.02070.0Rho/Rac
TgeneCITchr12:105629737chr12:120198859ENST0000026183317471091_1302726.02028.0Rho/Rac
TgeneCITchr12:105629737chr12:120198859ENST0000039252118481091_1302768.02070.0Rho/Rac


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APPL2-CIT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APPL2-CIT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPPL2C0013146Drug abuse1CTD_human
HgeneAPPL2C0013170Drug habituation1CTD_human
HgeneAPPL2C0013222Drug Use Disorders1CTD_human
HgeneAPPL2C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneAPPL2C0033578Prostatic Neoplasms1CTD_human
HgeneAPPL2C0038580Substance Dependence1CTD_human
HgeneAPPL2C0038586Substance Use Disorders1CTD_human
HgeneAPPL2C0236969Substance-Related Disorders1CTD_human
HgeneAPPL2C0376358Malignant neoplasm of prostate1CTD_human
HgeneAPPL2C0740858Substance abuse problem1CTD_human
HgeneAPPL2C1510472Drug Dependence1CTD_human
HgeneAPPL2C4316881Prescription Drug Abuse1CTD_human
TgeneC4310723MICROCEPHALY 17, PRIMARY, AUTOSOMAL RECESSIVE4CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC3711387Autosomal Recessive Primary Microcephaly1ORPHANET
TgeneC3809431MICROCEPHALY 11, PRIMARY, AUTOSOMAL RECESSIVE1GENOMICS_ENGLAND