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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:APPL2-NR0B1 (FusionGDB2 ID:HG55198TG190) |
Fusion Gene Summary for APPL2-NR0B1 |
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Fusion gene information | Fusion gene name: APPL2-NR0B1 | Fusion gene ID: hg55198tg190 | Hgene | Tgene | Gene symbol | APPL2 | NR0B1 | Gene ID | 55198 | 190 |
Gene name | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 | nuclear receptor subfamily 0 group B member 1 | |
Synonyms | DIP13B | AHC|AHCH|AHX|DAX-1|DAX1|DSS|GTD|HHG|NROB1|SRXY2 | |
Cytomap | ('APPL2')('NR0B1') 12q23.3 | Xp21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | DCC-interacting protein 13-betaDIP13 betaadapter protein containing PH domain, PTB domain and leucine zipper motif 2adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 | nuclear receptor subfamily 0 group B member 1DSS-AHC critical region on the X chromosome protein 1nuclear hormone receptornuclear receptor DAX-1truncated nuclear receptor subfamily 0 group B member 1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000258530, ENST00000539978, ENST00000551662, ENST00000549573, ENST00000546731, | ||
Fusion gene scores | * DoF score | 9 X 10 X 5=450 | 2 X 1 X 2=4 |
# samples | 10 | 3 | |
** MAII score | log2(10/450*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/4*10)=2.90689059560852 | |
Context | PubMed: APPL2 [Title/Abstract] AND NR0B1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | APPL2(105597481)-NR0B1(30322940), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | APPL2-NR0B1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. APPL2-NR0B1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. APPL2-NR0B1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. APPL2-NR0B1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | APPL2 | GO:0006606 | protein import into nucleus | 26583432 |
Hgene | APPL2 | GO:0051289 | protein homotetramerization | 23055524 |
Hgene | APPL2 | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | 15016378 |
Tgene | NR0B1 | GO:0006694 | steroid biosynthetic process | 9384387 |
Tgene | NR0B1 | GO:0008104 | protein localization | 11875111 |
Tgene | NR0B1 | GO:0033144 | negative regulation of intracellular steroid hormone receptor signaling pathway | 11875111 |
Tgene | NR0B1 | GO:0045892 | negative regulation of transcription, DNA-templated | 7990953|9384387 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | UCEC | TCGA-AJ-A3BD-01A | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - |
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Fusion Gene ORF analysis for APPL2-NR0B1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000258530 | ENST00000378963 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - |
5CDS-intron | ENST00000258530 | ENST00000453287 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - |
5CDS-intron | ENST00000539978 | ENST00000378963 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - |
5CDS-intron | ENST00000539978 | ENST00000453287 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - |
5CDS-intron | ENST00000551662 | ENST00000378963 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - |
5CDS-intron | ENST00000551662 | ENST00000453287 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - |
5UTR-3CDS | ENST00000549573 | ENST00000378970 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - |
5UTR-intron | ENST00000549573 | ENST00000378963 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - |
5UTR-intron | ENST00000549573 | ENST00000453287 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - |
In-frame | ENST00000258530 | ENST00000378970 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - |
In-frame | ENST00000539978 | ENST00000378970 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - |
In-frame | ENST00000551662 | ENST00000378970 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - |
intron-3CDS | ENST00000546731 | ENST00000378970 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - |
intron-intron | ENST00000546731 | ENST00000378963 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - |
intron-intron | ENST00000546731 | ENST00000453287 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000258530 | APPL2 | chr12 | 105597481 | - | ENST00000378970 | NR0B1 | chrX | 30322940 | - | 1548 | 930 | 79 | 999 | 306 |
ENST00000539978 | APPL2 | chr12 | 105597481 | - | ENST00000378970 | NR0B1 | chrX | 30322940 | - | 1628 | 1010 | 219 | 1079 | 286 |
ENST00000551662 | APPL2 | chr12 | 105597481 | - | ENST00000378970 | NR0B1 | chrX | 30322940 | - | 1411 | 793 | 23 | 862 | 279 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000258530 | ENST00000378970 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - | 0.000481771 | 0.9995183 |
ENST00000539978 | ENST00000378970 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - | 0.00117203 | 0.998828 |
ENST00000551662 | ENST00000378970 | APPL2 | chr12 | 105597481 | - | NR0B1 | chrX | 30322940 | - | 0.000747738 | 0.99925226 |
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Fusion Genomic Features for APPL2-NR0B1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for APPL2-NR0B1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:105597481/chrX:30322940) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000453287 | 0 | 2 | 205_469 | 0 | 401.0 | Domain | NR LBD | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000378970 | 0 | 2 | 461_466 | 389 | 471.0 | Motif | Note=AF-2 motif | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000453287 | 0 | 2 | 13_17 | 0 | 401.0 | Motif | Note=LXXLL motif 1 | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000453287 | 0 | 2 | 146_150 | 0 | 401.0 | Motif | Note=LXXLL motif 3 | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000453287 | 0 | 2 | 461_466 | 0 | 401.0 | Motif | Note=AF-2 motif | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000453287 | 0 | 2 | 80_84 | 0 | 401.0 | Motif | Note=LXXLL motif 2 | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000453287 | 0 | 2 | 1_253 | 0 | 401.0 | Region | Note=4 X 67 AA tandem repeats | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000453287 | 0 | 2 | 134_200 | 0 | 401.0 | Repeat | Note=3 | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000453287 | 0 | 2 | 1_67 | 0 | 401.0 | Repeat | Note=1 | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000453287 | 0 | 2 | 201_253 | 0 | 401.0 | Repeat | Note=4%3B truncated | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000453287 | 0 | 2 | 68_133 | 0 | 401.0 | Repeat | Note=2 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | APPL2 | chr12:105597481 | chrX:30322940 | ENST00000258530 | - | 9 | 21 | 277_375 | 234 | 665.0 | Domain | PH |
Hgene | APPL2 | chr12:105597481 | chrX:30322940 | ENST00000258530 | - | 9 | 21 | 3_268 | 234 | 665.0 | Domain | BAR |
Hgene | APPL2 | chr12:105597481 | chrX:30322940 | ENST00000258530 | - | 9 | 21 | 488_637 | 234 | 665.0 | Domain | PID |
Hgene | APPL2 | chr12:105597481 | chrX:30322940 | ENST00000539978 | - | 9 | 21 | 277_375 | 191 | 622.0 | Domain | PH |
Hgene | APPL2 | chr12:105597481 | chrX:30322940 | ENST00000539978 | - | 9 | 21 | 3_268 | 191 | 622.0 | Domain | BAR |
Hgene | APPL2 | chr12:105597481 | chrX:30322940 | ENST00000539978 | - | 9 | 21 | 488_637 | 191 | 622.0 | Domain | PID |
Hgene | APPL2 | chr12:105597481 | chrX:30322940 | ENST00000551662 | - | 9 | 21 | 277_375 | 240 | 671.0 | Domain | PH |
Hgene | APPL2 | chr12:105597481 | chrX:30322940 | ENST00000551662 | - | 9 | 21 | 3_268 | 240 | 671.0 | Domain | BAR |
Hgene | APPL2 | chr12:105597481 | chrX:30322940 | ENST00000551662 | - | 9 | 21 | 488_637 | 240 | 671.0 | Domain | PID |
Hgene | APPL2 | chr12:105597481 | chrX:30322940 | ENST00000258530 | - | 9 | 21 | 1_428 | 234 | 665.0 | Region | Required for RAB5A binding |
Hgene | APPL2 | chr12:105597481 | chrX:30322940 | ENST00000539978 | - | 9 | 21 | 1_428 | 191 | 622.0 | Region | Required for RAB5A binding |
Hgene | APPL2 | chr12:105597481 | chrX:30322940 | ENST00000551662 | - | 9 | 21 | 1_428 | 240 | 671.0 | Region | Required for RAB5A binding |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000378970 | 0 | 2 | 205_469 | 389 | 471.0 | Domain | NR LBD | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000378970 | 0 | 2 | 13_17 | 389 | 471.0 | Motif | Note=LXXLL motif 1 | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000378970 | 0 | 2 | 146_150 | 389 | 471.0 | Motif | Note=LXXLL motif 3 | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000378970 | 0 | 2 | 80_84 | 389 | 471.0 | Motif | Note=LXXLL motif 2 | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000378970 | 0 | 2 | 1_253 | 389 | 471.0 | Region | Note=4 X 67 AA tandem repeats | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000378970 | 0 | 2 | 134_200 | 389 | 471.0 | Repeat | Note=3 | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000378970 | 0 | 2 | 1_67 | 389 | 471.0 | Repeat | Note=1 | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000378970 | 0 | 2 | 201_253 | 389 | 471.0 | Repeat | Note=4%3B truncated | |
Tgene | NR0B1 | chr12:105597481 | chrX:30322940 | ENST00000378970 | 0 | 2 | 68_133 | 389 | 471.0 | Repeat | Note=2 |
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Fusion Gene Sequence for APPL2-NR0B1 |
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>5690_5690_1_APPL2-NR0B1_APPL2_chr12_105597481_ENST00000258530_NR0B1_chrX_30322940_ENST00000378970_length(transcript)=1548nt_BP=930nt TTTCCCTGCCGGGCGCGCCACACTTCCTGTTGATCCGGCTCGGCCGGGGGCTGGGCCGGCGGGCAGGCGGCGGCGGCCACTGGCCAGGCG TGGACGCGCGCGGGGCCGCCGCGGGCACGGAGTGGCCGCCGCGTCGCCTGAGCCCAGAGCCGGGGAGTGCTCTCGGCCGCCGCGTCTCCT GCCCTCTGTCCTTCCAACCCAGCCCTCGGCTGAGCCGCGCCGCACCATGCCCGCCGTGGACAAGCTCCTGCTAGAGGAGGCGTTGCAGGA CAGCCCCCAGACTCGCTCTTTACTGAGCGTGTTTGAAGAAGATGCTGGCACCCTCACAGACTATACCAACCAGCTGCTCCAGGCAATGCA GCGCGTCTATGGAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGGCATATGAAAAACAGAACTTTGCTCT TGGCAAAGGTGATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTGGTGGATGAGCTTAATCTTCTCCATACAGAGCTGGCTAA ACAGTTGGCAGACACAATGGTTCTACCTATCATACAATTCCGAGAAAAGGATCTCACAGAAGTAAGCACTTTAAAGGATCTATTTGGACT CGCTAGCAATGAGCATGACCTCTCAATGGCAAAATACAGCAGGCTGCCTAAGAAAAAGGAGAATGAGAAGGTGAAGACCGAAGTCGGAAA AGAGGTGGCCGCGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAGTACTACTGTGCCCTCAACGCGCTGCAGTACAGAAAGCAAATGGC CATGATGGAGCCCATGATAGGCTTTGCCCATGGACAGATTAACTTTTTTAAGAAGGGAGCAGAGATGTTTTCCAAACGTATGGACAGCTT TTTATCCTCCGTTGCAGACATGGTTCAAAGACGTGCCGGGCCTGCAGTGCGTGAAGTACATTCAGGGACTCCAGTGGGGAACTCAGCAAA TACTCAGTGAACACACCAGGATGACGCACCAAGGGCCCCATGACAGATTCATCGAACTTAATAGTACCCTTTTCCTGCTGAGATTCATCA ATGCCAATGTCATTGCTGAACTGTTCTTCAGGCCCATCATCGGCACAGTCAGCATGGATGATATGATGCTGGAAATGCTCTGTACAAAGA TATAAAGTCATGTGGGCCACACAAGTGCAGTAGTGCAGTTCACCATGAGGGAAGAATAAAGAGCTGTGGGCAAAAGAGTGTAAAATATTT TAAAATAAACTTTCTTAATATTTTTACATGCAGAGTATTTTTGTATTCAATTAAAGAAATAATTTTATTCCAGACAGTCACAAATTTCTC TGTTCCATAGTTAAAGAAGACATTTGCCAACAGGTAGCATAGCTCTGTACATCTTTTAAAAAAAAAATAGCAGGGTACTAGTATAATAAG CTATTTTCACAAGTGTAGCAATTTCATGGAACCTGCTCAAATCAAATTTGTACATATTGTTATAATAAATTTTAAGGTCTTAACTATTAA >5690_5690_1_APPL2-NR0B1_APPL2_chr12_105597481_ENST00000258530_NR0B1_chrX_30322940_ENST00000378970_length(amino acids)=306AA_BP=283 MARRGRARGRRGHGVAAASPEPRAGECSRPPRLLPSVLPTQPSAEPRRTMPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLL QAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVSTLKD LFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQYYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKR -------------------------------------------------------------- >5690_5690_2_APPL2-NR0B1_APPL2_chr12_105597481_ENST00000539978_NR0B1_chrX_30322940_ENST00000378970_length(transcript)=1628nt_BP=1010nt TCTATTCATGGACTCCTTTTTAGTTTGCAGTGCTGCACGATGCATTGTAAAACTAGTCTGTGTGCATACACATGCGTTATTTCTGCTTAC CTCTCATATGTGGGAAGCTGAACATTTTAGGGATTAAGAAATCTGCCTCCATTGTTGTTTAGAAGCCTCTGCTCCTTGCCTGGCACTACT GGCTGTTGGGAATGTGAAGATAAATAAGAGTGACTACCCTTGACTGGTTCACAGTTTGTTCCAGAGACAGATAATGAGGCAACAGTTCCA GTACAGTGTGAATCCTGCTGCGATAGGAACACAAATGCAGCTTTGAGCTCCTGCAGCTTGTACTTCTTCAGGGGCTTATTCTCTTGTCCT ACTCGCTCTTTACTGAGCGTGTTTGAAGAAGATGCTGGCACCCTCACAGACTATACCAACCAGCTGCTCCAGGCAATGCAGCGCGTCTAT GGAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGGCATATGAAAAACAGAACTTTGCTCTTGGCAAAGGT GATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTGGTGGATGAGCTTAATCTTCTCCATACAGAGCTGGCTAAACAGTTGGCA GACACAATGGTTCTACCTATCATACAATTCCGAGAAAAGGATCTCACAGAAGTAAGCACTTTAAAGGATCTATTTGGACTCGCTAGCAAT GAGCATGACCTCTCAATGGCAAAATACAGCAGGCTGCCTAAGAAAAAGGAGAATGAGAAGGTGAAGACCGAAGTCGGAAAAGAGGTGGCC GCGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAGTACTACTGTGCCCTCAACGCGCTGCAGTACAGAAAGCAAATGGCCATGATGGAG CCCATGATAGGCTTTGCCCATGGACAGATTAACTTTTTTAAGAAGGGAGCAGAGATGTTTTCCAAACGTATGGACAGCTTTTTATCCTCC GTTGCAGACATGGTTCAAAGACGTGCCGGGCCTGCAGTGCGTGAAGTACATTCAGGGACTCCAGTGGGGAACTCAGCAAATACTCAGTGA ACACACCAGGATGACGCACCAAGGGCCCCATGACAGATTCATCGAACTTAATAGTACCCTTTTCCTGCTGAGATTCATCAATGCCAATGT CATTGCTGAACTGTTCTTCAGGCCCATCATCGGCACAGTCAGCATGGATGATATGATGCTGGAAATGCTCTGTACAAAGATATAAAGTCA TGTGGGCCACACAAGTGCAGTAGTGCAGTTCACCATGAGGGAAGAATAAAGAGCTGTGGGCAAAAGAGTGTAAAATATTTTAAAATAAAC TTTCTTAATATTTTTACATGCAGAGTATTTTTGTATTCAATTAAAGAAATAATTTTATTCCAGACAGTCACAAATTTCTCTGTTCCATAG TTAAAGAAGACATTTGCCAACAGGTAGCATAGCTCTGTACATCTTTTAAAAAAAAAATAGCAGGGTACTAGTATAATAAGCTATTTTCAC AAGTGTAGCAATTTCATGGAACCTGCTCAAATCAAATTTGTACATATTGTTATAATAAATTTTAAGGTCTTAACTATTAACTTGATTGAA >5690_5690_2_APPL2-NR0B1_APPL2_chr12_105597481_ENST00000539978_NR0B1_chrX_30322940_ENST00000378970_length(amino acids)=286AA_BP=263 MTGSQFVPETDNEATVPVQCESCCDRNTNAALSSCSLYFFRGLFSCPTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQL SKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVSTLKDLFGLASNEHDLSMAKYSRLP KKKENEKVKTEVGKEVAAARRKQHLSSLQYYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQRRAGPAV -------------------------------------------------------------- >5690_5690_3_APPL2-NR0B1_APPL2_chr12_105597481_ENST00000551662_NR0B1_chrX_30322940_ENST00000378970_length(transcript)=1411nt_BP=793nt AGTGCTCTCGGCCGCCGCGTCTCCTGCCCTCTGTCCTTCCAACCCAGCCCTCGGCTGAGCCGCGCCGCACCATGCCCGCCGTGGACAAGC TCCTGCTAGAGGAGGCGTTGCAGGACAGCCCCCAGACTCGCTCTTTACTGAGCGTGTTTGAAGAAGATGCTGGCACCCTCACAGACTATA CCAACCAGCTGCTCCAGGCAATGCAGCGCGTCTATGGAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGG CATATGAAAAACAGAACTTTGCTCTTGGCAAAGGTGATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTGGTGGATGAGCTTA ATCTTCTCCATACAGAGCTGGCTAAACAGTTGGCAGACACAATGGTTCTACCTATCATACAATTCCGAGAAAAGGATCTCACAGAAGTAA GCACTTTAAAGGATCTATTTGGACTCGCTAGCAATGATGTCTGTTTATTTTTAGAGCATGACCTCTCAATGGCAAAATACAGCAGGCTGC CTAAGAAAAAGGAGAATGAGAAGGTGAAGACCGAAGTCGGAAAAGAGGTGGCCGCGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAGT ACTACTGTGCCCTCAACGCGCTGCAGTACAGAAAGCAAATGGCCATGATGGAGCCCATGATAGGCTTTGCCCATGGACAGATTAACTTTT TTAAGAAGGGAGCAGAGATGTTTTCCAAACGTATGGACAGCTTTTTATCCTCCGTTGCAGACATGGTTCAAAGACGTGCCGGGCCTGCAG TGCGTGAAGTACATTCAGGGACTCCAGTGGGGAACTCAGCAAATACTCAGTGAACACACCAGGATGACGCACCAAGGGCCCCATGACAGA TTCATCGAACTTAATAGTACCCTTTTCCTGCTGAGATTCATCAATGCCAATGTCATTGCTGAACTGTTCTTCAGGCCCATCATCGGCACA GTCAGCATGGATGATATGATGCTGGAAATGCTCTGTACAAAGATATAAAGTCATGTGGGCCACACAAGTGCAGTAGTGCAGTTCACCATG AGGGAAGAATAAAGAGCTGTGGGCAAAAGAGTGTAAAATATTTTAAAATAAACTTTCTTAATATTTTTACATGCAGAGTATTTTTGTATT CAATTAAAGAAATAATTTTATTCCAGACAGTCACAAATTTCTCTGTTCCATAGTTAAAGAAGACATTTGCCAACAGGTAGCATAGCTCTG TACATCTTTTAAAAAAAAAATAGCAGGGTACTAGTATAATAAGCTATTTTCACAAGTGTAGCAATTTCATGGAACCTGCTCAAATCAAAT >5690_5690_3_APPL2-NR0B1_APPL2_chr12_105597481_ENST00000551662_NR0B1_chrX_30322940_ENST00000378970_length(amino acids)=279AA_BP=256 MPSVLPTQPSAEPRRTMPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFA LGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVSTLKDLFGLASNDVCLFLEHDLSMAKYSRLPKKKENEK VKTEVGKEVAAARRKQHLSSLQYYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQRRAGPAVREVHSGT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for APPL2-NR0B1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for APPL2-NR0B1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for APPL2-NR0B1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | APPL2 | C0013146 | Drug abuse | 1 | CTD_human |
Hgene | APPL2 | C0013170 | Drug habituation | 1 | CTD_human |
Hgene | APPL2 | C0013222 | Drug Use Disorders | 1 | CTD_human |
Hgene | APPL2 | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human |
Hgene | APPL2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | APPL2 | C0038580 | Substance Dependence | 1 | CTD_human |
Hgene | APPL2 | C0038586 | Substance Use Disorders | 1 | CTD_human |
Hgene | APPL2 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Hgene | APPL2 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Hgene | APPL2 | C0740858 | Substance abuse problem | 1 | CTD_human |
Hgene | APPL2 | C1510472 | Drug Dependence | 1 | CTD_human |
Hgene | APPL2 | C4316881 | Prescription Drug Abuse | 1 | CTD_human |
Tgene | C0342482 | X-linked Adrenal Hypoplasia | 19 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
Tgene | C0795887 | Complex Glycerol Kinase Deficiency | 2 | CTD_human | |
Tgene | C1868690 | Hypoadrenocorticism, familial | 2 | CTD_human | |
Tgene | C4505291 | Xp21 Contiguous Gene Deletion Syndrome | 2 | CTD_human | |
Tgene | C0020619 | Hypogonadism | 1 | CTD_human | |
Tgene | C0028960 | Oligospermia | 1 | CTD_human | |
Tgene | C0220766 | Congenital hypoplasia of adrenal gland | 1 | GENOMICS_ENGLAND | |
Tgene | C0271623 | Hypogonadotropic hypogonadism | 1 | CTD_human | |
Tgene | C0432475 | XX males | 1 | ORPHANET | |
Tgene | C0948896 | Primary hypogonadism | 1 | CTD_human | |
Tgene | C1848296 | DOSAGE-SENSITIVE SEX REVERSAL | 1 | CTD_human;GENOMICS_ENGLAND | |
Tgene | C2936419 | 46, XX Testicular Disorders of Sex Development | 1 | ORPHANET | |
Tgene | C3489396 | Hypogonadism, Isolated Hypogonadotropic | 1 | CTD_human | |
Tgene | C4510744 | 46,XY partial gonadal dysgenesis | 1 | ORPHANET |