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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACOXL-KLHL23 (FusionGDB2 ID:HG55289TG151230)

Fusion Gene Summary for ACOXL-KLHL23

check button Fusion gene summary
Fusion gene informationFusion gene name: ACOXL-KLHL23
Fusion gene ID: hg55289tg151230
HgeneTgene
Gene symbol

ACOXL

KLHL23

Gene ID

55289

151230

Gene nameacyl-CoA oxidase likekelch like family member 23
Synonyms-DITHP
Cytomap('ACOXL')('KLHL23')

2q13

2q31.1

Type of geneprotein-codingprotein-coding
Descriptionacyl-coenzyme A oxidase-like proteinacyl-CoA oxidase-like proteinkelch-like protein 23kelch-like 23
Modification date2020031320200313
UniProtAcc

Q9NUZ1

Q8NBE8

Ensembl transtripts involved in fusion geneENST00000340561, ENST00000389811, 
ENST00000439055, ENST00000496981, 
Fusion gene scores* DoF score7 X 7 X 2=981 X 1 X 1=1
# samples 61
** MAII scorelog2(6/98*10)=-0.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ACOXL [Title/Abstract] AND KLHL23 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACOXL(111526041)-KLHL23(170597895), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-G2-AA3F-01AACOXLchr2

111526041

+KLHL23chr2

170597895

+
ChimerDB4BLCATCGA-G2-AA3FACOXLchr2

111526041

+KLHL23chr2

170597895

+


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Fusion Gene ORF analysis for ACOXL-KLHL23

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000340561ENST00000392647ACOXLchr2

111526041

+KLHL23chr2

170597895

+
5CDS-5UTRENST00000340561ENST00000602521ACOXLchr2

111526041

+KLHL23chr2

170597895

+
5CDS-5UTRENST00000389811ENST00000392647ACOXLchr2

111526041

+KLHL23chr2

170597895

+
5CDS-5UTRENST00000389811ENST00000602521ACOXLchr2

111526041

+KLHL23chr2

170597895

+
5CDS-5UTRENST00000439055ENST00000392647ACOXLchr2

111526041

+KLHL23chr2

170597895

+
5CDS-5UTRENST00000439055ENST00000602521ACOXLchr2

111526041

+KLHL23chr2

170597895

+
Frame-shiftENST00000340561ENST00000272797ACOXLchr2

111526041

+KLHL23chr2

170597895

+
Frame-shiftENST00000389811ENST00000272797ACOXLchr2

111526041

+KLHL23chr2

170597895

+
Frame-shiftENST00000439055ENST00000272797ACOXLchr2

111526041

+KLHL23chr2

170597895

+
intron-3CDSENST00000496981ENST00000272797ACOXLchr2

111526041

+KLHL23chr2

170597895

+
intron-5UTRENST00000496981ENST00000392647ACOXLchr2

111526041

+KLHL23chr2

170597895

+
intron-5UTRENST00000496981ENST00000602521ACOXLchr2

111526041

+KLHL23chr2

170597895

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ACOXL-KLHL23


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACOXLchr2111526041+KLHL23chr2170597894+0.522665260.47733477
ACOXLchr2111526041+KLHL23chr2170597894+0.522665260.47733477
ACOXLchr2111526041+KLHL23chr2170597894+0.522665260.47733477
ACOXLchr2111526041+KLHL23chr2170597894+0.522665260.47733477


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACOXL-KLHL23


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:111526041/:170597895)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACOXL

Q9NUZ1

KLHL23

Q8NBE8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ACOXL-KLHL23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ACOXL-KLHL23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACOXL-KLHL23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACOXL-KLHL23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACOXLC0023434Chronic Lymphocytic Leukemia1CTD_human