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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:FBXW7-ARHGAP10 (FusionGDB2 ID:HG55294TG79658) |
Fusion Gene Summary for FBXW7-ARHGAP10 |
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Fusion gene information | Fusion gene name: FBXW7-ARHGAP10 | Fusion gene ID: hg55294tg79658 | Hgene | Tgene | Gene symbol | FBXW7 | ARHGAP10 | Gene ID | 55294 | 79658 |
Gene name | F-box and WD repeat domain containing 7 | Rho GTPase activating protein 10 | |
Synonyms | AGO|CDC4|FBW6|FBW7|FBX30|FBXO30|FBXW6|SEL-10|SEL10|hAgo|hCdc4 | GRAF2|PS-GAP|PSGAP | |
Cytomap | ('FBXW7')('ARHGAP10') 4q31.3 | 4q31.23 | |
Type of gene | protein-coding | protein-coding | |
Description | F-box/WD repeat-containing protein 7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligaseF-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)F-box protein FBW7F-box protein FBX30F-box protein SEL-10archipelagohomolog of | rho GTPase-activating protein 10GTPase regulator associated with focal adhesion kinase 2graf-related protein 2rho-type GTPase-activating protein 10 | |
Modification date | 20200327 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000281708, ENST00000603548, ENST00000604095, ENST00000604872, ENST00000263981, ENST00000296555, ENST00000393956, ENST00000603841, | ||
Fusion gene scores | * DoF score | 15 X 9 X 10=1350 | 12 X 11 X 6=792 |
# samples | 17 | 12 | |
** MAII score | log2(17/1350*10)=-2.98935275580049 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/792*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FBXW7 [Title/Abstract] AND ARHGAP10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | FBXW7(153456093)-ARHGAP10(148993144), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FBXW7 | GO:0016567 | protein ubiquitination | 12354302|15103331 |
Hgene | FBXW7 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 15103331|17434132 |
Hgene | FBXW7 | GO:0031398 | positive regulation of protein ubiquitination | 12628165 |
Hgene | FBXW7 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity | 20208556 |
Hgene | FBXW7 | GO:0050821 | protein stabilization | 20208556 |
Hgene | FBXW7 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity | 12628165 |
Hgene | FBXW7 | GO:1901800 | positive regulation of proteasomal protein catabolic process | 23858059 |
Hgene | FBXW7 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | 23858059 |
Hgene | FBXW7 | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 20208556 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BLCA | TCGA-DK-A2HX-01A | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
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Fusion Gene ORF analysis for FBXW7-ARHGAP10 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000281708 | ENST00000336498 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
5UTR-3CDS | ENST00000281708 | ENST00000414545 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
5UTR-3CDS | ENST00000603548 | ENST00000336498 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
5UTR-3CDS | ENST00000603548 | ENST00000414545 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
5UTR-3CDS | ENST00000604095 | ENST00000336498 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
5UTR-3CDS | ENST00000604095 | ENST00000414545 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
5UTR-3CDS | ENST00000604872 | ENST00000336498 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
5UTR-3CDS | ENST00000604872 | ENST00000414545 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
5UTR-3UTR | ENST00000281708 | ENST00000510076 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
5UTR-3UTR | ENST00000603548 | ENST00000510076 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
5UTR-3UTR | ENST00000604095 | ENST00000510076 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
5UTR-3UTR | ENST00000604872 | ENST00000510076 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
intron-3CDS | ENST00000263981 | ENST00000336498 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
intron-3CDS | ENST00000263981 | ENST00000414545 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
intron-3CDS | ENST00000296555 | ENST00000336498 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
intron-3CDS | ENST00000296555 | ENST00000414545 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
intron-3CDS | ENST00000393956 | ENST00000336498 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
intron-3CDS | ENST00000393956 | ENST00000414545 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
intron-3CDS | ENST00000603841 | ENST00000336498 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
intron-3CDS | ENST00000603841 | ENST00000414545 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
intron-3UTR | ENST00000263981 | ENST00000510076 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
intron-3UTR | ENST00000296555 | ENST00000510076 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
intron-3UTR | ENST00000393956 | ENST00000510076 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
intron-3UTR | ENST00000603841 | ENST00000510076 | FBXW7 | chr4 | 153456093 | - | ARHGAP10 | chr4 | 148993144 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for FBXW7-ARHGAP10 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
FBXW7 | chr4 | 153456092 | - | ARHGAP10 | chr4 | 148993143 | + | 4.13E-05 | 0.99995875 |
FBXW7 | chr4 | 153456092 | - | ARHGAP10 | chr4 | 148993143 | + | 4.13E-05 | 0.99995875 |
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Fusion Protein Features for FBXW7-ARHGAP10 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:153456093/:148993144) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for FBXW7-ARHGAP10 |
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Fusion Gene PPI Analysis for FBXW7-ARHGAP10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FBXW7-ARHGAP10 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FBXW7-ARHGAP10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FBXW7 | C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 2 | CGI;CTD_human |
Hgene | FBXW7 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human;UNIPROT |
Hgene | FBXW7 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | FBXW7 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Hgene | FBXW7 | C0017638 | Glioma | 1 | CTD_human |
Hgene | FBXW7 | C0259783 | mixed gliomas | 1 | CTD_human |
Hgene | FBXW7 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Hgene | FBXW7 | C0476089 | Endometrial Carcinoma | 1 | CGI;CTD_human |
Hgene | FBXW7 | C0555198 | Malignant Glioma | 1 | CTD_human |
Hgene | FBXW7 | C0678222 | Breast Carcinoma | 1 | CTD_human |
Hgene | FBXW7 | C0919532 | Genomic Instability | 1 | CTD_human |
Hgene | FBXW7 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
Hgene | FBXW7 | C1368275 | Pigmented Basal Cell Carcinoma | 1 | CTD_human |
Hgene | FBXW7 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | FBXW7 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
Hgene | FBXW7 | C4721806 | Carcinoma, Basal Cell | 1 | CTD_human |
Tgene | C0004238 | Atrial Fibrillation | 2 | CTD_human | |
Tgene | C0235480 | Paroxysmal atrial fibrillation | 2 | CTD_human | |
Tgene | C2585653 | Persistent atrial fibrillation | 2 | CTD_human | |
Tgene | C3468561 | familial atrial fibrillation | 2 | CTD_human |