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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BTBD2-SBNO2 (FusionGDB2 ID:HG55643TG22904)

Fusion Gene Summary for BTBD2-SBNO2

check button Fusion gene summary
Fusion gene informationFusion gene name: BTBD2-SBNO2
Fusion gene ID: hg55643tg22904
HgeneTgene
Gene symbol

BTBD2

SBNO2

Gene ID

55643

22904

Gene nameBTB domain containing 2strawberry notch homolog 2
Synonyms-KIAA0963|SNO|STNO
Cytomap('BTBD2')('SBNO2')

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
DescriptionBTB/POZ domain-containing protein 2BTB (POZ) domain containing 2protein strawberry notch homolog 2
Modification date2020032720200313
UniProtAcc

Q9BX70

.
Ensembl transtripts involved in fusion geneENST00000590646, ENST00000255608, 
Fusion gene scores* DoF score13 X 11 X 11=15738 X 5 X 6=240
# samples 1810
** MAII scorelog2(18/1573*10)=-3.12744985908601
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BTBD2 [Title/Abstract] AND SBNO2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBTBD2(2013546)-SBNO2(1127764), # samples:2
Anticipated loss of major functional domain due to fusion event.BTBD2-SBNO2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD2-SBNO2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD2-SBNO2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD2-SBNO2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD2-SBNO2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSBNO2

GO:0071354

cellular response to interleukin-6

25903009


check buttonFusion gene breakpoints across BTBD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SBNO2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-0979BTBD2chr19

1997342

-SBNO2chr19

1111613

-
ChimerDB4OVTCGA-24-1436-01ABTBD2chr19

2013546

-SBNO2chr19

1127764

-
ChimerDB4OVTCGA-24-1436-01ABTBD2chr19

2015296

-SBNO2chr19

1127764

-


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Fusion Gene ORF analysis for BTBD2-SBNO2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000590646ENST00000361757BTBD2chr19

1997342

-SBNO2chr19

1111613

-
5UTR-3CDSENST00000590646ENST00000438103BTBD2chr19

1997342

-SBNO2chr19

1111613

-
5UTR-3CDSENST00000590646ENST00000587024BTBD2chr19

1997342

-SBNO2chr19

1111613

-
Frame-shiftENST00000255608ENST00000361757BTBD2chr19

1997342

-SBNO2chr19

1111613

-
Frame-shiftENST00000255608ENST00000438103BTBD2chr19

1997342

-SBNO2chr19

1111613

-
Frame-shiftENST00000255608ENST00000587024BTBD2chr19

1997342

-SBNO2chr19

1111613

-
In-frameENST00000255608ENST00000361757BTBD2chr19

2015296

-SBNO2chr19

1127764

-
In-frameENST00000255608ENST00000438103BTBD2chr19

2015296

-SBNO2chr19

1127764

-
In-frameENST00000255608ENST00000587024BTBD2chr19

2015296

-SBNO2chr19

1127764

-
intron-3CDSENST00000255608ENST00000361757BTBD2chr19

2013546

-SBNO2chr19

1127764

-
intron-3CDSENST00000255608ENST00000438103BTBD2chr19

2013546

-SBNO2chr19

1127764

-
intron-3CDSENST00000255608ENST00000587024BTBD2chr19

2013546

-SBNO2chr19

1127764

-
intron-3CDSENST00000590646ENST00000361757BTBD2chr19

2013546

-SBNO2chr19

1127764

-
intron-3CDSENST00000590646ENST00000361757BTBD2chr19

2015296

-SBNO2chr19

1127764

-
intron-3CDSENST00000590646ENST00000438103BTBD2chr19

2013546

-SBNO2chr19

1127764

-
intron-3CDSENST00000590646ENST00000438103BTBD2chr19

2015296

-SBNO2chr19

1127764

-
intron-3CDSENST00000590646ENST00000587024BTBD2chr19

2013546

-SBNO2chr19

1127764

-
intron-3CDSENST00000590646ENST00000587024BTBD2chr19

2015296

-SBNO2chr19

1127764

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000255608BTBD2chr192015296-ENST00000361757SBNO2chr191127764-482942430142451314
ENST00000255608BTBD2chr192015296-ENST00000587024SBNO2chr191127764-479542430142151304
ENST00000255608BTBD2chr192015296-ENST00000438103SBNO2chr191127764-482442430142451314

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000255608ENST00000361757BTBD2chr192015296-SBNO2chr191127764-0.0096685820.9903314
ENST00000255608ENST00000587024BTBD2chr192015296-SBNO2chr191127764-0.0100980670.9899019
ENST00000255608ENST00000438103BTBD2chr192015296-SBNO2chr191127764-0.0098221540.9901778

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Fusion Genomic Features for BTBD2-SBNO2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BTBD2-SBNO2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:2013546/chr19:1127764)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BTBD2

Q9BX70

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBTBD2chr19:2015296chr19:1127764ENST00000255608-1941_54135526.0Compositional biasNote=Poly-Ala
TgeneSBNO2chr19:2015296chr19:1127764ENST000003617573321234_1294931367.0Compositional biasNote=Pro-rich
TgeneSBNO2chr19:2015296chr19:1127764ENST00000361757332183_195931367.0Compositional biasNote=Poly-Glu
TgeneSBNO2chr19:2015296chr19:1127764ENST000004381030291234_1294361310.0Compositional biasNote=Pro-rich
TgeneSBNO2chr19:2015296chr19:1127764ENST00000438103029183_195361310.0Compositional biasNote=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBTBD2chr19:2015296chr19:1127764ENST00000255608-19117_187135526.0DomainBTB


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Fusion Gene Sequence for BTBD2-SBNO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10463_10463_1_BTBD2-SBNO2_BTBD2_chr19_2015296_ENST00000255608_SBNO2_chr19_1127764_ENST00000361757_length(transcript)=4829nt_BP=424nt
CACGCCGCAGCCACAAAATGGCGGCGGGTGGGAGCGGCGGGCGTGCGTCGTGCCCGCCGGGGGTCGGGGTCGGCCCGGGCACGGGGGGCA
GTCCCGGGCCCAGCGCCAACGCCGCCGCCACCCCGGCCCCCGGCAACGCGGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCC
CTGGGCCGACGCCGCCCGCCCCGCCGGGCCCCGGGACAGACGCGCAGGCCGCGGGCGCGGAGCGGGCGGAGGAGGCGGCGGGCCCGGGGG
CGGCGGCGCTGCAGCGCGAGGCCGCGTACAACTGGCAGGCCAGCAAGCCCACCGTGCAGGAGCGCTTCGCCTTCCTCTTCAACAACGAGG
TGCTGTGCGACGTGCACTTCCTGGTGGGCAAGGGGCTCAGCTCGCAGCGCATCCCCGCGCACAGGACTCCTCCTATTTTGAGGACTTCTC
CAACATCTCCATCTTCTCCTCGTCCGTGGACTCCCTGTCGGACATCGTGGACACGCCCGACTTCCTGCCGGCTGACAGCCTCAACCAGGT
GTCCACCATCTGGGACGATAACCCTGCCCCCTCCACCCACGATAAGCTGTTCCAGCTCAGCAGGCCGTTTGCAGGCTTCGAGGACTTTCT
GCCCTCCCACAGCACCCCGCTTCTCGTCAGCTACCAGGAGCAGAGTGTGCAGAGCCAGCCAGAGGAGGAGGACGAGGCTGAGGAGGAGGA
GGCGGAGGAGCTGGGGCACACAGAGACCTACGCCGACTACGTGCCGTCCAAGTCCAAGATCGGGAAGCAGCACCCAGACCGCGTGGTGGA
GACCAGCACACTGTCCAGCGTCCCACCCCCAGACATCACCTACACCCTGGCCCTGCCCTCGGACAGCGGGGCCCTGTCTGCCCTGCAGCT
AGAGGCCATCACCTACGCCTGCCAGCAACACGAGGTCCTGCTCCCCAGCGGGCAGCGCGCGGGCTTTCTCATCGGCGATGGGGCCGGCGT
GGGCAAAGGCCGGACGGTGGCCGGAGTCATCCTGGAGAACCACCTGCGCGGCCGGAAGAAAGCATTGTGGTTCAGCGTCTCCAACGACCT
CAAGTACGATGCGGAGCGCGACCTGCGGGACATCGAAGCCACGGGCATCGCGGTGCACGCGCTCAGCAAGATCAAGTACGGTGACACCAC
TACCTCAGAGGGCGTCCTCTTCGCCACCTACTCCGCCCTGATTGGGGAGAGCCAGGCCGGCGGCCAGCACCGCACTCGCCTCCGGCAGAT
CCTGGACTGGTGTGGGGAGGCCTTCGAGGGCGTCATCGTGTTCGACGAGTGTCACAAAGCCAAGAATGCCGGCTCCACCAAGATGGGCAA
GGCTGTGCTAGACCTGCAGAACAAGCTGCCCCTGGCCCGCGTGGTCTACGCCAGCGCCACAGGTGCCTCTGAGCCTCGGAACATGATCTA
CATGAGCCGCTTGGGTATCTGGGGCGAGGGCACACCCTTCCGGAACTTTGAGGAGTTCCTGCACGCCATCGAGAAGAGGGGCGTTGGCGC
CATGGAGATCGTGGCCATGGACATGAAGGTCAGCGGCATGTACATCGCACGCCAGCTCAGCTTCTCCGGCGTCACCTTCCGCATCGAGGA
GATCCCGCTGGCCCCAGCCTTCGAGTGCGTCTACAACCGCGCGGCCCTGCTGTGGGCCGAGGCCCTGAACGTGTTCCAGCAGGCGGCCGA
CTGGATCGGCCTGGAGTCGCGCAAGTCCCTGTGGGGCCAGTTCTGGTCGGCACACCAGCGCTTCTTCAAGTATCTGTGCATCGCAGCCAA
GGTGCGCCGGCTGGTGGAGCTGGCCCGAGAGGAGCTGGCGCGAGACAAGTGCGTGGTCATCGGGCTGCAGTCCACGGGCGAGGCGCGCAC
GCGGGAGGTGCTGGGGGAGAACGATGGGCACCTCAACTGCTTCGTCTCGGCCGCTGAAGGCGTGTTCCTGTCGCTAATTCAGAAGCACTT
TCCGTCCACCAAGAGAAAGCGGGACAGAGGAGCGGGCAGCAAGCGGAAACGGCGACCTCGGGGACGCGGGGCCAAAGCCCCCCGGCTGGC
GTGCGAGACAGCGGGCGTCATCCGCATCAGTGACGACAGCAGCACGGAGTCGGACCCTGGCCTGGACAGCGACTTCAACTCCTCCCCCGA
GTCCCTGGTGGATGACGACGTTGTCATCGTTGATGCAGTCGGGCTCCCCAGTGACGACCGGGGACCCCTGTGCCTCCTGCAGAGAGACCC
GCATGGCCCCGGGGTCCTGGAGCGGGTGGAGCGGCTGAAGCAGGATCTGCTGGACAAAGTGCGGCGGCTGGGCCGGGAACTGCCAGTCAA
CACCCTGGACGAGCTCATCGACCAGCTGGGCGGCCCCCAGCGGGTGGCGGAGATGACCGGCAGGAAAGGCCGCGTGGTGTCCAGGCCCGA
CGGGACGGTGGCCTTCGAGTCGCGGGCAGAGCAGGGTCTGTCCATCGACCACGTGAACCTCAGGGAGAAGCAGCGCTTCATGAGCGGCGA
GAAGCTCGTGGCCATCATCTCGGAGGCCTCCAGCTCGGGTGTCTCCCTCCAAGCCGACCGCCGTGTCCAGAACCAGCGGCGCCGCGTGCA
CATGACCTTGGAGCTGCCGTGGAGCGCCGACCGCGCCATCCAGCAGTTCGGCCGCACCCACCGGTCCAACCAGGTCTCCGCGCCAGAGTA
TGTCTTCCTCATCTCGGAGCTGGCCGGGGAGCGCCGGTTCGCCTCCATCGTGGCCAAGCGCCTGGAGAGTCTGGGGGCCCTGACCCACGG
AGACCGCCGCGCCACGGAGTCCCGTGACCTCAGCAAGTACAACTTTGAGAACAAGTATGGCACCCGGGCCCTGCACTGTGTCCTCACCAC
CATCCTGAGCCAGACTGAGAACAAAGTGCCTGTGCCCCAGGGATACCCTGGAGGGGTCCCCACCTTCTTCCGGGACATGAAGCAGGGCCT
GCTGTCTGTGGGCATTGGTGGCCGGGAGTCCCGGAATGGCTGCCTGGACGTGGAGAAGGACTGTTCCATCACCAAGTTCCTGAACCGCAT
CCTGGGGCTGGAGGTGCACAAGCAGAACGCCCTGTTCCAGTACTTCTCAGACACCTTCGACCACCTCATCGAGATGGACAAGCGGGAGGG
CAAATACGACATGGGCATCCTGGACCTTGCTCCCGGTATCGAGGAGATCTACGAGGAGAGCCAGCAGGTGTTCCTGGCTCCCGGGCACCC
GCAGGACGGGCAGGTGGTCTTCTACAAGATCAGCGTGGACCGCGGCCTGAAGTGGGAGGACGCCTTTGCCAAGTCGCTGGCGCTGACGGG
CCCCTATGACGGCTTCTACCTCTCCTACAAGGTCCGCGGTAACAAGCCCAGCTGCCTGCTGGCGGAGCAGAACCGCGGCCAGTTCTTCAC
GGTGTACAAGCCCAACATCGGCCGGCAGAGCCAGCTGGAGGCCCTGGACAGCCTCCGCCGCAAGTTCCACCGGGTCACCGCGGAGGAGGC
CAAGGAGCCCTGGGAGAGTGGCTACGCTTTGTCGCTGACGCACTGCAGCCACAGCGCCTGGAACCGGCACTGCCGGCTGGCGCAGGAGGG
TAAGGACTGCCTGCAGGGGCTGCGGCTGCGGCACCACTACATGCTGTGCGGCGCGCTGCTGCGCGTGTGGGGCCGCATCGCCGCCGTCAT
GGCCGACGTCAGCAGCAGCAGCTACCTGCAGATCGTGCGGCTGAAGACCAAGGACAGGAAGAAGCAAGTGGGCATCAAGATCCCCGAGGG
CTGCGTGCGCCGGGTGCTGCAGGAGCTGCGGCTGATGGATGCGGACGTGAAGCGCAGGCAGGCGCCCGCCCTGGGCTGCCCCGCCCCGCC
CGCCCCGCGCCCGCTGGCGCTGCCTTGCGGCCCCGGAGAGGTGCTGGACCTCACCTACAGCCCCCCGGCCGAGGCCTTCCCGCCGCCCCC
GCACTTCTCTTTCCCGGCGCCGCTGTCCCTGGACGCCGGCCCCGGCGTCGTGCCGCTGGGCACCCCCGACGCCCAGGCCGACCCTGCGGC
CCTCGCGCACCAGGGCTGCGACATCAACTTCAAGGAGGTGCTGGAGGACATGCTGCGCTCGCTGCACGCGGGGCCGCCCTCCGAGGGCGC
GCTGGGGGAGGGCGCGGGGGCGGGGGGCGCGGCGGGCGGTGGTCCCGAGCGGCAGAGCGTGATCCAGTTCAGCCCACCCTTCCCCGGCGC
CCAGGCTCCTCTCTGACACGCCTTTAGGCGAAACATGCCCCAAGACACAGGGACCGTTTCTCCCCTAGGAGCAGCGGTGGGGAGCAGGGC
CAAGGTCCCCTGACCACTGCTCAGAGGAGCCCTAGGCCCTGGCCGCAGTGCCTTCAGCGCCCGACCCGGGCCCCCACCTGGTCAGCCCTG
GCGGGGCCCACTCAGGACAGCTGGGGGCCGGGGCGTGGCAGGGCCCTCTCTGTGCCTCTCCTCCCAAGTAGGAAGGGGCTCCGGGTGGCT
GCTCTGGGACTGGGCACCCACAAGGGCTCAGTGGGCCCAAACCCTTGAAATCCGTGAAACCGGGTGGTCCCAAGAGCTAGAAACTCAGGA
AACCCCAGGTGCTCAGGGCCCCGCGTCTCGGGGGCTCCGTGGGGCAGACCCCTGCTAATATATGCAATTCTCCCTCCCCCAGCCCTTCCC
TGACCCCTAAGTTATTGCCCGCTCACCTCTCCCAGGCCCCAGGCCGCGGAGCTGGCAGGGTGGCGCCTGCGGTTTCTATGTATTTATAGC

>10463_10463_1_BTBD2-SBNO2_BTBD2_chr19_2015296_ENST00000255608_SBNO2_chr19_1127764_ENST00000361757_length(amino acids)=1314AA_BP=2
MAGQQAHRAGALRLPLQQRGAVRRALPGGQGAQLAAHPRAQDSSYFEDFSNISIFSSSVDSLSDIVDTPDFLPADSLNQVSTIWDDNPAP
STHDKLFQLSRPFAGFEDFLPSHSTPLLVSYQEQSVQSQPEEEDEAEEEEAEELGHTETYADYVPSKSKIGKQHPDRVVETSTLSSVPPP
DITYTLALPSDSGALSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAGVILENHLRGRKKALWFSVSNDLKYDAERDLRD
IEATGIAVHALSKIKYGDTTTSEGVLFATYSALIGESQAGGQHRTRLRQILDWCGEAFEGVIVFDECHKAKNAGSTKMGKAVLDLQNKLP
LARVVYASATGASEPRNMIYMSRLGIWGEGTPFRNFEEFLHAIEKRGVGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLAPAFECV
YNRAALLWAEALNVFQQAADWIGLESRKSLWGQFWSAHQRFFKYLCIAAKVRRLVELAREELARDKCVVIGLQSTGEARTREVLGENDGH
LNCFVSAAEGVFLSLIQKHFPSTKRKRDRGAGSKRKRRPRGRGAKAPRLACETAGVIRISDDSSTESDPGLDSDFNSSPESLVDDDVVIV
DAVGLPSDDRGPLCLLQRDPHGPGVLERVERLKQDLLDKVRRLGRELPVNTLDELIDQLGGPQRVAEMTGRKGRVVSRPDGTVAFESRAE
QGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGE
RRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENKYGTRALHCVLTTILSQTENKVPVPQGYPGGVPTFFRDMKQGLLSVGIGGRES
RNGCLDVEKDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEMDKREGKYDMGILDLAPGIEEIYEESQQVFLAPGHPQDGQVVFYKI
SVDRGLKWEDAFAKSLALTGPYDGFYLSYKVRGNKPSCLLAEQNRGQFFTVYKPNIGRQSQLEALDSLRRKFHRVTAEEAKEPWESGYAL
SLTHCSHSAWNRHCRLAQEGKDCLQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKDRKKQVGIKIPEGCVRRVLQELR
LMDADVKRRQAPALGCPAPPAPRPLALPCGPGEVLDLTYSPPAEAFPPPPHFSFPAPLSLDAGPGVVPLGTPDAQADPAALAHQGCDINF

--------------------------------------------------------------
>10463_10463_2_BTBD2-SBNO2_BTBD2_chr19_2015296_ENST00000255608_SBNO2_chr19_1127764_ENST00000438103_length(transcript)=4824nt_BP=424nt
CACGCCGCAGCCACAAAATGGCGGCGGGTGGGAGCGGCGGGCGTGCGTCGTGCCCGCCGGGGGTCGGGGTCGGCCCGGGCACGGGGGGCA
GTCCCGGGCCCAGCGCCAACGCCGCCGCCACCCCGGCCCCCGGCAACGCGGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCC
CTGGGCCGACGCCGCCCGCCCCGCCGGGCCCCGGGACAGACGCGCAGGCCGCGGGCGCGGAGCGGGCGGAGGAGGCGGCGGGCCCGGGGG
CGGCGGCGCTGCAGCGCGAGGCCGCGTACAACTGGCAGGCCAGCAAGCCCACCGTGCAGGAGCGCTTCGCCTTCCTCTTCAACAACGAGG
TGCTGTGCGACGTGCACTTCCTGGTGGGCAAGGGGCTCAGCTCGCAGCGCATCCCCGCGCACAGGACTCCTCCTATTTTGAGGACTTCTC
CAACATCTCCATCTTCTCCTCGTCCGTGGACTCCCTGTCGGACATCGTGGACACGCCCGACTTCCTGCCGGCTGACAGCCTCAACCAGGT
GTCCACCATCTGGGACGATAACCCTGCCCCCTCCACCCACGATAAGCTGTTCCAGCTCAGCAGGCCGTTTGCAGGCTTCGAGGACTTTCT
GCCCTCCCACAGCACCCCGCTTCTCGTCAGCTACCAGGAGCAGAGTGTGCAGAGCCAGCCAGAGGAGGAGGACGAGGCTGAGGAGGAGGA
GGCGGAGGAGCTGGGGCACACAGAGACCTACGCCGACTACGTGCCGTCCAAGTCCAAGATCGGGAAGCAGCACCCAGACCGCGTGGTGGA
GACCAGCACACTGTCCAGCGTCCCACCCCCAGACATCACCTACACCCTGGCCCTGCCCTCGGACAGCGGGGCCCTGTCTGCCCTGCAGCT
AGAGGCCATCACCTACGCCTGCCAGCAACACGAGGTCCTGCTCCCCAGCGGGCAGCGCGCGGGCTTTCTCATCGGCGATGGGGCCGGCGT
GGGCAAAGGCCGGACGGTGGCCGGAGTCATCCTGGAGAACCACCTGCGCGGCCGGAAGAAAGCATTGTGGTTCAGCGTCTCCAACGACCT
CAAGTACGATGCGGAGCGCGACCTGCGGGACATCGAAGCCACGGGCATCGCGGTGCACGCGCTCAGCAAGATCAAGTACGGTGACACCAC
TACCTCAGAGGGCGTCCTCTTCGCCACCTACTCCGCCCTGATTGGGGAGAGCCAGGCCGGCGGCCAGCACCGCACTCGCCTCCGGCAGAT
CCTGGACTGGTGTGGGGAGGCCTTCGAGGGCGTCATCGTGTTCGACGAGTGTCACAAAGCCAAGAATGCCGGCTCCACCAAGATGGGCAA
GGCTGTGCTAGACCTGCAGAACAAGCTGCCCCTGGCCCGCGTGGTCTACGCCAGCGCCACAGGTGCCTCTGAGCCTCGGAACATGATCTA
CATGAGCCGCTTGGGTATCTGGGGCGAGGGCACACCCTTCCGGAACTTTGAGGAGTTCCTGCACGCCATCGAGAAGAGGGGCGTTGGCGC
CATGGAGATCGTGGCCATGGACATGAAGGTCAGCGGCATGTACATCGCACGCCAGCTCAGCTTCTCCGGCGTCACCTTCCGCATCGAGGA
GATCCCGCTGGCCCCAGCCTTCGAGTGCGTCTACAACCGCGCGGCCCTGCTGTGGGCCGAGGCCCTGAACGTGTTCCAGCAGGCGGCCGA
CTGGATCGGCCTGGAGTCGCGCAAGTCCCTGTGGGGCCAGTTCTGGTCGGCACACCAGCGCTTCTTCAAGTATCTGTGCATCGCAGCCAA
GGTGCGCCGGCTGGTGGAGCTGGCCCGAGAGGAGCTGGCGCGAGACAAGTGCGTGGTCATCGGGCTGCAGTCCACGGGCGAGGCGCGCAC
GCGGGAGGTGCTGGGGGAGAACGATGGGCACCTCAACTGCTTCGTCTCGGCCGCTGAAGGCGTGTTCCTGTCGCTAATTCAGAAGCACTT
TCCGTCCACCAAGAGAAAGCGGGACAGAGGAGCGGGCAGCAAGCGGAAACGGCGACCTCGGGGACGCGGGGCCAAAGCCCCCCGGCTGGC
GTGCGAGACAGCGGGCGTCATCCGCATCAGTGACGACAGCAGCACGGAGTCGGACCCTGGCCTGGACAGCGACTTCAACTCCTCCCCCGA
GTCCCTGGTGGATGACGACGTTGTCATCGTTGATGCAGTCGGGCTCCCCAGTGACGACCGGGGACCCCTGTGCCTCCTGCAGAGAGACCC
GCATGGCCCCGGGGTCCTGGAGCGGGTGGAGCGGCTGAAGCAGGATCTGCTGGACAAAGTGCGGCGGCTGGGCCGGGAACTGCCAGTCAA
CACCCTGGACGAGCTCATCGACCAGCTGGGCGGCCCCCAGCGGGTGGCGGAGATGACCGGCAGGAAAGGCCGCGTGGTGTCCAGGCCCGA
CGGGACGGTGGCCTTCGAGTCGCGGGCAGAGCAGGGTCTGTCCATCGACCACGTGAACCTCAGGGAGAAGCAGCGCTTCATGAGCGGCGA
GAAGCTCGTGGCCATCATCTCGGAGGCCTCCAGCTCGGGTGTCTCCCTCCAAGCCGACCGCCGTGTCCAGAACCAGCGGCGCCGCGTGCA
CATGACCTTGGAGCTGCCGTGGAGCGCCGACCGCGCCATCCAGCAGTTCGGCCGCACCCACCGGTCCAACCAGGTCTCCGCGCCAGAGTA
TGTCTTCCTCATCTCGGAGCTGGCCGGGGAGCGCCGGTTCGCCTCCATCGTGGCCAAGCGCCTGGAGAGTCTGGGGGCCCTGACCCACGG
AGACCGCCGCGCCACGGAGTCCCGTGACCTCAGCAAGTACAACTTTGAGAACAAGTATGGCACCCGGGCCCTGCACTGTGTCCTCACCAC
CATCCTGAGCCAGACTGAGAACAAAGTGCCTGTGCCCCAGGGATACCCTGGAGGGGTCCCCACCTTCTTCCGGGACATGAAGCAGGGCCT
GCTGTCTGTGGGCATTGGTGGCCGGGAGTCCCGGAATGGCTGCCTGGACGTGGAGAAGGACTGTTCCATCACCAAGTTCCTGAACCGCAT
CCTGGGGCTGGAGGTGCACAAGCAGAACGCCCTGTTCCAGTACTTCTCAGACACCTTCGACCACCTCATCGAGATGGACAAGCGGGAGGG
CAAATACGACATGGGCATCCTGGACCTTGCTCCCGGTATCGAGGAGATCTACGAGGAGAGCCAGCAGGTGTTCCTGGCTCCCGGGCACCC
GCAGGACGGGCAGGTGGTCTTCTACAAGATCAGCGTGGACCGCGGCCTGAAGTGGGAGGACGCCTTTGCCAAGTCGCTGGCGCTGACGGG
CCCCTATGACGGCTTCTACCTCTCCTACAAGGTCCGCGGTAACAAGCCCAGCTGCCTGCTGGCGGAGCAGAACCGCGGCCAGTTCTTCAC
GGTGTACAAGCCCAACATCGGCCGGCAGAGCCAGCTGGAGGCCCTGGACAGCCTCCGCCGCAAGTTCCACCGGGTCACCGCGGAGGAGGC
CAAGGAGCCCTGGGAGAGTGGCTACGCTTTGTCGCTGACGCACTGCAGCCACAGCGCCTGGAACCGGCACTGCCGGCTGGCGCAGGAGGG
TAAGGACTGCCTGCAGGGGCTGCGGCTGCGGCACCACTACATGCTGTGCGGCGCGCTGCTGCGCGTGTGGGGCCGCATCGCCGCCGTCAT
GGCCGACGTCAGCAGCAGCAGCTACCTGCAGATCGTGCGGCTGAAGACCAAGGACAGGAAGAAGCAAGTGGGCATCAAGATCCCCGAGGG
CTGCGTGCGCCGGGTGCTGCAGGAGCTGCGGCTGATGGATGCGGACGTGAAGCGCAGGCAGGCGCCCGCCCTGGGCTGCCCCGCCCCGCC
CGCCCCGCGCCCGCTGGCGCTGCCTTGCGGCCCCGGAGAGGTGCTGGACCTCACCTACAGCCCCCCGGCCGAGGCCTTCCCGCCGCCCCC
GCACTTCTCTTTCCCGGCGCCGCTGTCCCTGGACGCCGGCCCCGGCGTCGTGCCGCTGGGCACCCCCGACGCCCAGGCCGACCCTGCGGC
CCTCGCGCACCAGGGCTGCGACATCAACTTCAAGGAGGTGCTGGAGGACATGCTGCGCTCGCTGCACGCGGGGCCGCCCTCCGAGGGCGC
GCTGGGGGAGGGCGCGGGGGCGGGGGGCGCGGCGGGCGGTGGTCCCGAGCGGCAGAGCGTGATCCAGTTCAGCCCACCCTTCCCCGGCGC
CCAGGCTCCTCTCTGACACGCCTTTAGGCGAAACATGCCCCAAGACACAGGGACCGTTTCTCCCCTAGGAGCAGCGGTGGGGAGCAGGGC
CAAGGTCCCCTGACCACTGCTCAGAGGAGCCCTAGGCCCTGGCCGCAGTGCCTTCAGCGCCCGACCCGGGCCCCCACCTGGTCAGCCCTG
GCGGGGCCCACTCAGGACAGCTGGGGGCCGGGGCGTGGCAGGGCCCTCTCTGTGCCTCTCCTCCCAAGTAGGAAGGGGCTCCGGGTGGCT
GCTCTGGGACTGGGCACCCACAAGGGCTCAGTGGGCCCAAACCCTTGAAATCCGTGAAACCGGGTGGTCCCAAGAGCTAGAAACTCAGGA
AACCCCAGGTGCTCAGGGCCCCGCGTCTCGGGGGCTCCGTGGGGCAGACCCCTGCTAATATATGCAATTCTCCCTCCCCCAGCCCTTCCC
TGACCCCTAAGTTATTGCCCGCTCACCTCTCCCAGGCCCCAGGCCGCGGAGCTGGCAGGGTGGCGCCTGCGGTTTCTATGTATTTATAGC

>10463_10463_2_BTBD2-SBNO2_BTBD2_chr19_2015296_ENST00000255608_SBNO2_chr19_1127764_ENST00000438103_length(amino acids)=1314AA_BP=2
MAGQQAHRAGALRLPLQQRGAVRRALPGGQGAQLAAHPRAQDSSYFEDFSNISIFSSSVDSLSDIVDTPDFLPADSLNQVSTIWDDNPAP
STHDKLFQLSRPFAGFEDFLPSHSTPLLVSYQEQSVQSQPEEEDEAEEEEAEELGHTETYADYVPSKSKIGKQHPDRVVETSTLSSVPPP
DITYTLALPSDSGALSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAGVILENHLRGRKKALWFSVSNDLKYDAERDLRD
IEATGIAVHALSKIKYGDTTTSEGVLFATYSALIGESQAGGQHRTRLRQILDWCGEAFEGVIVFDECHKAKNAGSTKMGKAVLDLQNKLP
LARVVYASATGASEPRNMIYMSRLGIWGEGTPFRNFEEFLHAIEKRGVGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLAPAFECV
YNRAALLWAEALNVFQQAADWIGLESRKSLWGQFWSAHQRFFKYLCIAAKVRRLVELAREELARDKCVVIGLQSTGEARTREVLGENDGH
LNCFVSAAEGVFLSLIQKHFPSTKRKRDRGAGSKRKRRPRGRGAKAPRLACETAGVIRISDDSSTESDPGLDSDFNSSPESLVDDDVVIV
DAVGLPSDDRGPLCLLQRDPHGPGVLERVERLKQDLLDKVRRLGRELPVNTLDELIDQLGGPQRVAEMTGRKGRVVSRPDGTVAFESRAE
QGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGE
RRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENKYGTRALHCVLTTILSQTENKVPVPQGYPGGVPTFFRDMKQGLLSVGIGGRES
RNGCLDVEKDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEMDKREGKYDMGILDLAPGIEEIYEESQQVFLAPGHPQDGQVVFYKI
SVDRGLKWEDAFAKSLALTGPYDGFYLSYKVRGNKPSCLLAEQNRGQFFTVYKPNIGRQSQLEALDSLRRKFHRVTAEEAKEPWESGYAL
SLTHCSHSAWNRHCRLAQEGKDCLQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKDRKKQVGIKIPEGCVRRVLQELR
LMDADVKRRQAPALGCPAPPAPRPLALPCGPGEVLDLTYSPPAEAFPPPPHFSFPAPLSLDAGPGVVPLGTPDAQADPAALAHQGCDINF

--------------------------------------------------------------
>10463_10463_3_BTBD2-SBNO2_BTBD2_chr19_2015296_ENST00000255608_SBNO2_chr19_1127764_ENST00000587024_length(transcript)=4795nt_BP=424nt
CACGCCGCAGCCACAAAATGGCGGCGGGTGGGAGCGGCGGGCGTGCGTCGTGCCCGCCGGGGGTCGGGGTCGGCCCGGGCACGGGGGGCA
GTCCCGGGCCCAGCGCCAACGCCGCCGCCACCCCGGCCCCCGGCAACGCGGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCC
CTGGGCCGACGCCGCCCGCCCCGCCGGGCCCCGGGACAGACGCGCAGGCCGCGGGCGCGGAGCGGGCGGAGGAGGCGGCGGGCCCGGGGG
CGGCGGCGCTGCAGCGCGAGGCCGCGTACAACTGGCAGGCCAGCAAGCCCACCGTGCAGGAGCGCTTCGCCTTCCTCTTCAACAACGAGG
TGCTGTGCGACGTGCACTTCCTGGTGGGCAAGGGGCTCAGCTCGCAGCGCATCCCCGCGCACAGGACTCCTCCTATTTTGAGGACTTCTC
CAACATCTCCATCTTCTCCTCGTCCGTGGACTCCCTGTCGGACATCGTGGACACGCCCGACTTCCTGCCGGCTGACAGCCTCAACCAGGT
GTCCACCATCTGGGACGATAACCCTGCCCCCTCCACCCACGATAAGCTGTTCCAGCTCAGCAGGCCGTTTGCAGGCTTCGAGGACTTTCT
GCCCTCCCACAGCACCCCGCTTCTCGTCAGCTACCAGGAGCAGAGTGTGCAGAGCCAGCCAGAGGAGGAGGACGAGGCTGAGGAGGAGGA
GGCGGAGGAGCTGGGGCACACAGAGACCTACGCCGACTACGTGCCGTCCAAGTCCAAGATCGGGAAGCAGCACCCAGACCGCGTGGTGGA
GACCAGCACACTGTCCAGCGTCCCACCCCCAGACATCACCTACACCCTGGCCCTGCCCTCGGACAGCGGGGCCCTGTCTGCCCTGCAGCT
AGAGGCCATCACCTACGCCTGCCAGCAACACGAGGTCCTGCTCCCCAGCGGGCAGCGCGCGGGCTTTCTCATCGGCGATGGGGCCGGCGT
GGGCAAAGGCCGGACGGTGGCCGGAGTCATCCTGGAGAACCACCTGCGCGGCCGGAAGAAAGCATTGTGGTTCAGCGTCTCCAACGACCT
CAAGTACGATGCGGAGCGCGACCTGCGGGACATCGAAGCCACGGGCATCGCGGTGCACGCGCTCAGCAAGATCAAGTACGGTGACACCAC
TACCTCAGAGGGCGTCCTCTTCGCCACCTACTCCGCCCTGATTGGGGAGAGCCAGGCCGGCGGCCAGCACCGCACTCGCCTCCGGCAGAT
CCTGGACTGGTGTGGGGAGGCCTTCGAGGGCGTCATCGTGTTCGACGAGTGTCACAAAGCCAAGAATGCCGGCTCCACCAAGATGGGCAA
GGCTGTGCTAGACCTGCAGAACAAGCTGCCCCTGGCCCGCGTGGTCTACGCCAGCGCCACAGGTGCCTCTGAGCCTCGGAACATGATCTA
CATGAGCCGCTTGGGTATCTGGGGCGAGGGCACACCCTTCCGGAACTTTGAGGAGTTCCTGCACGCCATCGAGAAGAGGGGCGTTGGCGC
CATGGAGATCGTGGCCATGGACATGAAGGTCAGCGGCATGTACATCGCACGCCAGCTCAGCTTCTCCGGCGTCACCTTCCGCATCGAGGA
GATCCCGCTGGCCCCAGCCTTCGAGTGCGTCTACAACCGCGCGGCCCTGCTGGCGGCCGACTGGATCGGCCTGGAGTCGCGCAAGTCCCT
GTGGGGCCAGTTCTGGTCGGCACACCAGCGCTTCTTCAAGTATCTGTGCATCGCAGCCAAGGTGCGCCGGCTGGTGGAGCTGGCCCGAGA
GGAGCTGGCGCGAGACAAGTGCGTGGTCATCGGGCTGCAGTCCACGGGCGAGGCGCGCACGCGGGAGGTGCTGGGGGAGAACGATGGGCA
CCTCAACTGCTTCGTCTCGGCCGCTGAAGGCGTGTTCCTGTCGCTAATTCAGAAGCACTTTCCGTCCACCAAGAGAAAGCGGGACAGAGG
AGCGGGCAGCAAGCGGAAACGGCGACCTCGGGGACGCGGGGCCAAAGCCCCCCGGCTGGCGTGCGAGACAGCGGGCGTCATCCGCATCAG
TGACGACAGCAGCACGGAGTCGGACCCTGGCCTGGACAGCGACTTCAACTCCTCCCCCGAGTCCCTGGTGGATGACGACGTTGTCATCGT
TGATGCAGTCGGGCTCCCCAGTGACGACCGGGGACCCCTGTGCCTCCTGCAGAGAGACCCGCATGGCCCCGGGGTCCTGGAGCGGGTGGA
GCGGCTGAAGCAGGATCTGCTGGACAAAGTGCGGCGGCTGGGCCGGGAACTGCCAGTCAACACCCTGGACGAGCTCATCGACCAGCTGGG
CGGCCCCCAGCGGGTGGCGGAGATGACCGGCAGGAAAGGCCGCGTGGTGTCCAGGCCCGACGGGACGGTGGCCTTCGAGTCGCGGGCAGA
GCAGGGTCTGTCCATCGACCACGTGAACCTCAGGGAGAAGCAGCGCTTCATGAGCGGCGAGAAGCTCGTGGCCATCATCTCGGAGGCCTC
CAGCTCGGGTGTCTCCCTCCAAGCCGACCGCCGTGTCCAGAACCAGCGGCGCCGCGTGCACATGACCTTGGAGCTGCCGTGGAGCGCCGA
CCGCGCCATCCAGCAGTTCGGCCGCACCCACCGGTCCAACCAGGTCTCCGCGCCAGAGTATGTCTTCCTCATCTCGGAGCTGGCCGGGGA
GCGCCGGTTCGCCTCCATCGTGGCCAAGCGCCTGGAGAGTCTGGGGGCCCTGACCCACGGAGACCGCCGCGCCACGGAGTCCCGTGACCT
CAGCAAGTACAACTTTGAGAACAAGTATGGCACCCGGGCCCTGCACTGTGTCCTCACCACCATCCTGAGCCAGACTGAGAACAAAGTGCC
TGTGCCCCAGGGATACCCTGGAGGGGTCCCCACCTTCTTCCGGGACATGAAGCAGGGCCTGCTGTCTGTGGGCATTGGTGGCCGGGAGTC
CCGGAATGGCTGCCTGGACGTGGAGAAGGACTGTTCCATCACCAAGTTCCTGAACCGCATCCTGGGGCTGGAGGTGCACAAGCAGAACGC
CCTGTTCCAGTACTTCTCAGACACCTTCGACCACCTCATCGAGATGGACAAGCGGGAGGGCAAATACGACATGGGCATCCTGGACCTTGC
TCCCGGTATCGAGGAGATCTACGAGGAGAGCCAGCAGGTGTTCCTGGCTCCCGGGCACCCGCAGGACGGGCAGGTGGTCTTCTACAAGAT
CAGCGTGGACCGCGGCCTGAAGTGGGAGGACGCCTTTGCCAAGTCGCTGGCGCTGACGGGCCCCTATGACGGCTTCTACCTCTCCTACAA
GGTCCGCGGTAACAAGCCCAGCTGCCTGCTGGCGGAGCAGAACCGCGGCCAGTTCTTCACGGTGTACAAGCCCAACATCGGCCGGCAGAG
CCAGCTGGAGGCCCTGGACAGCCTCCGCCGCAAGTTCCACCGGGTCACCGCGGAGGAGGCCAAGGAGCCCTGGGAGAGTGGCTACGCTTT
GTCGCTGACGCACTGCAGCCACAGCGCCTGGAACCGGCACTGCCGGCTGGCGCAGGAGGGTAAGGACTGCCTGCAGGGGCTGCGGCTGCG
GCACCACTACATGCTGTGCGGCGCGCTGCTGCGCGTGTGGGGCCGCATCGCCGCCGTCATGGCCGACGTCAGCAGCAGCAGCTACCTGCA
GATCGTGCGGCTGAAGACCAAGGACAGGAAGAAGCAAGTGGGCATCAAGATCCCCGAGGGCTGCGTGCGCCGGGTGCTGCAGGAGCTGCG
GCTGATGGATGCGGACGTGAAGCGCAGGCAGGCGCCCGCCCTGGGCTGCCCCGCCCCGCCCGCCCCGCGCCCGCTGGCGCTGCCTTGCGG
CCCCGGAGAGGTGCTGGACCTCACCTACAGCCCCCCGGCCGAGGCCTTCCCGCCGCCCCCGCACTTCTCTTTCCCGGCGCCGCTGTCCCT
GGACGCCGGCCCCGGCGTCGTGCCGCTGGGCACCCCCGACGCCCAGGCCGACCCTGCGGCCCTCGCGCACCAGGGCTGCGACATCAACTT
CAAGGAGGTGCTGGAGGACATGCTGCGCTCGCTGCACGCGGGGCCGCCCTCCGAGGGCGCGCTGGGGGAGGGCGCGGGGGCGGGGGGCGC
GGCGGGCGGTGGTCCCGAGCGGCAGAGCGTGATCCAGTTCAGCCCACCCTTCCCCGGCGCCCAGGCTCCTCTCTGACACGCCTTTAGGCG
AAACATGCCCCAAGACACAGGGACCGTTTCTCCCCTAGGAGCAGCGGTGGGGAGCAGGGCCAAGGTCCCCTGACCACTGCTCAGAGGAGC
CCTAGGCCCTGGCCGCAGTGCCTTCAGCGCCCGACCCGGGCCCCCACCTGGTCAGCCCTGGCGGGGCCCACTCAGGACAGCTGGGGGCCG
GGGCGTGGCAGGGCCCTCTCTGTGCCTCTCCTCCCAAGTAGGAAGGGGCTCCGGGTGGCTGCTCTGGGACTGGGCACCCACAAGGGCTCA
GTGGGCCCAAACCCTTGAAATCCGTGAAACCGGGTGGTCCCAAGAGCTAGAAACTCAGGAAACCCCAGGTGCTCAGGGCCCCGCGTCTCG
GGGGCTCCGTGGGGCAGACCCCTGCTAATATATGCAATTCTCCCTCCCCCAGCCCTTCCCTGACCCCTAAGTTATTGCCCGCTCACCTCT
CCCAGGCCCCAGGCCGCGGAGCTGGCAGGGTGGCGCCTGCGGTTTCTATGTATTTATAGCAAGTTCTGATGTACATATGTAAAGGACTTT

>10463_10463_3_BTBD2-SBNO2_BTBD2_chr19_2015296_ENST00000255608_SBNO2_chr19_1127764_ENST00000587024_length(amino acids)=1304AA_BP=2
MAGQQAHRAGALRLPLQQRGAVRRALPGGQGAQLAAHPRAQDSSYFEDFSNISIFSSSVDSLSDIVDTPDFLPADSLNQVSTIWDDNPAP
STHDKLFQLSRPFAGFEDFLPSHSTPLLVSYQEQSVQSQPEEEDEAEEEEAEELGHTETYADYVPSKSKIGKQHPDRVVETSTLSSVPPP
DITYTLALPSDSGALSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAGVILENHLRGRKKALWFSVSNDLKYDAERDLRD
IEATGIAVHALSKIKYGDTTTSEGVLFATYSALIGESQAGGQHRTRLRQILDWCGEAFEGVIVFDECHKAKNAGSTKMGKAVLDLQNKLP
LARVVYASATGASEPRNMIYMSRLGIWGEGTPFRNFEEFLHAIEKRGVGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLAPAFECV
YNRAALLAADWIGLESRKSLWGQFWSAHQRFFKYLCIAAKVRRLVELAREELARDKCVVIGLQSTGEARTREVLGENDGHLNCFVSAAEG
VFLSLIQKHFPSTKRKRDRGAGSKRKRRPRGRGAKAPRLACETAGVIRISDDSSTESDPGLDSDFNSSPESLVDDDVVIVDAVGLPSDDR
GPLCLLQRDPHGPGVLERVERLKQDLLDKVRRLGRELPVNTLDELIDQLGGPQRVAEMTGRKGRVVSRPDGTVAFESRAEQGLSIDHVNL
REKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIVAKR
LESLGALTHGDRRATESRDLSKYNFENKYGTRALHCVLTTILSQTENKVPVPQGYPGGVPTFFRDMKQGLLSVGIGGRESRNGCLDVEKD
CSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEMDKREGKYDMGILDLAPGIEEIYEESQQVFLAPGHPQDGQVVFYKISVDRGLKWED
AFAKSLALTGPYDGFYLSYKVRGNKPSCLLAEQNRGQFFTVYKPNIGRQSQLEALDSLRRKFHRVTAEEAKEPWESGYALSLTHCSHSAW
NRHCRLAQEGKDCLQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKDRKKQVGIKIPEGCVRRVLQELRLMDADVKRRQ
APALGCPAPPAPRPLALPCGPGEVLDLTYSPPAEAFPPPPHFSFPAPLSLDAGPGVVPLGTPDAQADPAALAHQGCDINFKEVLEDMLRS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BTBD2-SBNO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BTBD2-SBNO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BTBD2-SBNO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0036341Schizophrenia1PSYGENET