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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PRKACB-MARK2 (FusionGDB2 ID:HG5567TG2011)

Fusion Gene Summary for PRKACB-MARK2

Fusion gene summary

Fusion gene information	Fusion gene name: PRKACB-MARK2
	Fusion gene ID: hg5567tg2011
		Hgene	Tgene
	Gene symbol	PRKACB	MARK2
	Gene ID	5567	2011
	Gene name	protein kinase cAMP-activated catalytic subunit beta	microtubule affinity regulating kinase 2
	Synonyms	PKA C-beta\|PKACB	EMK-1\|EMK1\|PAR-1\|Par-1b\|Par1b
	Cytomap	('PRKACB')('MARK2') 1p31.1	11q13.1
	Type of gene	protein-coding	protein-coding
	Description	cAMP-dependent protein kinase catalytic subunit betacAMP-dependent protein kinase catalytic beta subunit isoform 4abprotein kinase A catalytic subunit betaprotein kinase, cAMP-dependent, beta catalytic subunitprotein kinase, cAMP-dependent, catalytic,	serine/threonine-protein kinase MARK2ELKL motif kinase 1MAP/microtubule affinity-regulating kinase 2PAR1 homolog bSer/Thr protein kinase PAR-1Bserine/threonine protein kinase EMKtesticular tissue protein Li 117
	Modification date	20200313	20200329
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000470673, ENST00000370685, ENST00000370680, ENST00000370682, ENST00000370688, ENST00000370689, ENST00000394838, ENST00000394839,
Fusion gene scores	* DoF score	9 X 7 X 4=252	7 X 6 X 3=126
	# samples	9	10
	** MAII score	log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/126*10)=-0.333423733725192 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PRKACB [Title/Abstract] AND MARK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PRKACB(84610231)-MARK2(63662630), # samples:1
Anticipated loss of major functional domain due to fusion event.	PRKACB-MARK2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PRKACB-MARK2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PRKACB-MARK2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. PRKACB-MARK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PRKACB-MARK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PRKACB	GO:0006468	protein phosphorylation	12420224\|21880142
Tgene	MARK2	GO:0006468	protein phosphorylation	14976552
Tgene	MARK2	GO:0010976	positive regulation of neuron projection development	12429843
Tgene	MARK2	GO:0018105	peptidyl-serine phosphorylation	10542369\|16717194
Tgene	MARK2	GO:0030010	establishment of cell polarity	12429843
Tgene	MARK2	GO:0035556	intracellular signal transduction	14976552
Tgene	MARK2	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	15324659
Tgene	MARK2	GO:0070507	regulation of microtubule cytoskeleton organization	10542369

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-KB-A6F7	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+

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Fusion Gene ORF analysis for PRKACB-MARK2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000470673	ENST00000377809	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
3UTR-3CDS	ENST00000470673	ENST00000402010	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
3UTR-3CDS	ENST00000470673	ENST00000413835	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
3UTR-5UTR	ENST00000470673	ENST00000315032	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
3UTR-5UTR	ENST00000470673	ENST00000350490	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
3UTR-5UTR	ENST00000470673	ENST00000361128	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
3UTR-5UTR	ENST00000470673	ENST00000377810	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
3UTR-5UTR	ENST00000470673	ENST00000502399	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
3UTR-5UTR	ENST00000470673	ENST00000508192	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
3UTR-5UTR	ENST00000470673	ENST00000509502	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
3UTR-5UTR	ENST00000470673	ENST00000513765	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
3UTR-intron	ENST00000470673	ENST00000408948	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
3UTR-intron	ENST00000470673	ENST00000425897	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
5CDS-5UTR	ENST00000370685	ENST00000315032	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
5CDS-5UTR	ENST00000370685	ENST00000350490	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
5CDS-5UTR	ENST00000370685	ENST00000361128	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
5CDS-5UTR	ENST00000370685	ENST00000377810	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
5CDS-5UTR	ENST00000370685	ENST00000502399	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
5CDS-5UTR	ENST00000370685	ENST00000508192	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
5CDS-5UTR	ENST00000370685	ENST00000509502	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
5CDS-5UTR	ENST00000370685	ENST00000513765	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
5CDS-intron	ENST00000370685	ENST00000408948	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
5CDS-intron	ENST00000370685	ENST00000425897	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
Frame-shift	ENST00000370685	ENST00000377809	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
Frame-shift	ENST00000370685	ENST00000402010	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
Frame-shift	ENST00000370685	ENST00000413835	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000370680	ENST00000377809	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000370680	ENST00000402010	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000370680	ENST00000413835	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000370682	ENST00000377809	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000370682	ENST00000402010	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000370682	ENST00000413835	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000370688	ENST00000377809	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000370688	ENST00000402010	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000370688	ENST00000413835	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000370689	ENST00000377809	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000370689	ENST00000402010	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000370689	ENST00000413835	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000394838	ENST00000377809	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000394838	ENST00000402010	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000394838	ENST00000413835	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000394839	ENST00000377809	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000394839	ENST00000402010	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-3CDS	ENST00000394839	ENST00000413835	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370680	ENST00000315032	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370680	ENST00000350490	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370680	ENST00000361128	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370680	ENST00000377810	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370680	ENST00000502399	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370680	ENST00000508192	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370680	ENST00000509502	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370680	ENST00000513765	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370682	ENST00000315032	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370682	ENST00000350490	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370682	ENST00000361128	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370682	ENST00000377810	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370682	ENST00000502399	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370682	ENST00000508192	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370682	ENST00000509502	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370682	ENST00000513765	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370688	ENST00000315032	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370688	ENST00000350490	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370688	ENST00000361128	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370688	ENST00000377810	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370688	ENST00000502399	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370688	ENST00000508192	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370688	ENST00000509502	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370688	ENST00000513765	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370689	ENST00000315032	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370689	ENST00000350490	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370689	ENST00000361128	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370689	ENST00000377810	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370689	ENST00000502399	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370689	ENST00000508192	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370689	ENST00000509502	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000370689	ENST00000513765	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000394838	ENST00000315032	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000394838	ENST00000350490	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000394838	ENST00000361128	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000394838	ENST00000377810	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000394838	ENST00000502399	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000394838	ENST00000508192	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000394838	ENST00000509502	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000394838	ENST00000513765	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000394839	ENST00000315032	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000394839	ENST00000350490	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000394839	ENST00000361128	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000394839	ENST00000377810	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000394839	ENST00000502399	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000394839	ENST00000508192	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000394839	ENST00000509502	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-5UTR	ENST00000394839	ENST00000513765	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-intron	ENST00000370680	ENST00000408948	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-intron	ENST00000370680	ENST00000425897	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-intron	ENST00000370682	ENST00000408948	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-intron	ENST00000370682	ENST00000425897	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-intron	ENST00000370688	ENST00000408948	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-intron	ENST00000370688	ENST00000425897	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-intron	ENST00000370689	ENST00000408948	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-intron	ENST00000370689	ENST00000425897	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-intron	ENST00000394838	ENST00000408948	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-intron	ENST00000394838	ENST00000425897	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-intron	ENST00000394839	ENST00000408948	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+
intron-intron	ENST00000394839	ENST00000425897	PRKACB	chr1	84610231	+	MARK2	chr11	63662630	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for PRKACB-MARK2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PRKACB	chr1	84610231	+	MARK2	chr11	63662626	+	4.14E-08	1
PRKACB	chr1	84610231	+	MARK2	chr11	63662626	+	4.14E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRKACB-MARK2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:84610231/:63662630)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for PRKACB-MARK2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PRKACB-MARK2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PRKACB-MARK2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PRKACB-MARK2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PRKACB	C0005426	Biliary Tract Neoplasm	1	CTD_human
Hgene	PRKACB	C0009777	Conn Adenoma	1	CTD_human
Hgene	PRKACB	C0010481	Cushing Syndrome	1	CTD_human
Hgene	PRKACB	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	PRKACB	C0206667	Adrenal Cortical Adenoma	1	CTD_human
Hgene	PRKACB	C0206698	Cholangiocarcinoma	1	CTD_human
Hgene	PRKACB	C0345905	Intrahepatic Cholangiocarcinoma	1	CTD_human
Hgene	PRKACB	C0376358	Malignant neoplasm of prostate	1	CTD_human
Hgene	PRKACB	C0750952	Biliary Tract Cancer	1	CTD_human
Hgene	PRKACB	C3805278	Extrahepatic Cholangiocarcinoma	1	CTD_human
Tgene		C0036341	Schizophrenia	2	PSYGENET
Tgene		C0010606	Adenoid Cystic Carcinoma	1	CTD_human
Tgene		C0036095	Salivary Gland Neoplasms	1	CTD_human
Tgene		C0220636	Malignant neoplasm of salivary gland	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:PRKACB-MARK2 (FusionGDB2 ID:HG5567TG2011)

Fusion Gene Summary for PRKACB-MARK2

Fusion Gene ORF analysis for PRKACB-MARK2

Fusion Genomic Features for PRKACB-MARK2

Fusion Protein Features for PRKACB-MARK2

Fusion Gene Sequence for PRKACB-MARK2

Fusion Gene PPI Analysis for PRKACB-MARK2

Related Drugs for PRKACB-MARK2

Related Diseases for PRKACB-MARK2

Fusion Gene Studies
in Kim Lab