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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FRMD4A-C10orf112 (FusionGDB2 ID:HG55691TG340895)

Fusion Gene Summary for FRMD4A-C10orf112

check button Fusion gene summary
Fusion gene informationFusion gene name: FRMD4A-C10orf112
Fusion gene ID: hg55691tg340895
HgeneTgene
Gene symbol

FRMD4A

C10orf112

Gene ID

55691

340895

Gene nameFERM domain containing 4AMAM and LDL receptor class A domain containing 1
SynonymsCCAFCA|FRMD4|bA295P9.4C10orf112|DIET1|bA265G8.2
Cytomap('FRMD4A')('C10orf112')

10p13

10p12.31

Type of geneprotein-codingprotein-coding
DescriptionFERM domain-containing protein 4AFERM domain containing 4MAM and LDL-receptor class A domain-containing protein 1MAM and LDL-receptor class A domain-containing protein C10orf112novel MAM domain containing protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000357447, ENST00000358621, 
ENST00000378503, ENST00000342409, 
ENST00000475141, ENST00000492155, 
ENST00000493380, 
Fusion gene scores* DoF score16 X 15 X 7=16805 X 5 X 4=100
# samples 175
** MAII scorelog2(17/1680*10)=-3.30485458152842
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FRMD4A [Title/Abstract] AND C10orf112 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFRMD4A(13735898)-C10orf112(19780446), # samples:1
Anticipated loss of major functional domain due to fusion event.FRMD4A-C10orf112 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FRMD4A-C10orf112 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FRMD4A-C10orf112 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FRMD4A-C10orf112 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FRMD4A-C10orf112 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FRMD4A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across C10orf112 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-FG-A4MT-01AFRMD4Achr10

13735898

-C10orf112chr10

19780446

+


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Fusion Gene ORF analysis for FRMD4A-C10orf112

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000357447ENST00000492202FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
5CDS-3UTRENST00000358621ENST00000492202FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
5CDS-3UTRENST00000378503ENST00000492202FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
5CDS-5UTRENST00000357447ENST00000455457FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
5CDS-5UTRENST00000358621ENST00000455457FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
5CDS-5UTRENST00000378503ENST00000455457FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
Frame-shiftENST00000358621ENST00000454679FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
In-frameENST00000357447ENST00000454679FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
In-frameENST00000378503ENST00000454679FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
intron-3CDSENST00000342409ENST00000454679FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
intron-3CDSENST00000475141ENST00000454679FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
intron-3CDSENST00000492155ENST00000454679FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
intron-3CDSENST00000493380ENST00000454679FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
intron-3UTRENST00000342409ENST00000492202FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
intron-3UTRENST00000475141ENST00000492202FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
intron-3UTRENST00000492155ENST00000492202FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
intron-3UTRENST00000493380ENST00000492202FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
intron-5UTRENST00000342409ENST00000455457FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
intron-5UTRENST00000475141ENST00000455457FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
intron-5UTRENST00000492155ENST00000455457FRMD4Achr10

13735898

-C10orf112chr10

19780446

+
intron-5UTRENST00000493380ENST00000455457FRMD4Achr10

13735898

-C10orf112chr10

19780446

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357447FRMD4Achr1013735898-ENST00000454679C10orf112chr1019780446+302014863692780803
ENST00000378503FRMD4Achr1013735898-ENST00000454679C10orf112chr1019780446+2651111702411803

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357447ENST00000454679FRMD4Achr1013735898-C10orf112chr1019780446+0.001132170.99886787
ENST00000378503ENST00000454679FRMD4Achr1013735898-C10orf112chr1019780446+0.0010386450.9989613

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Fusion Genomic Features for FRMD4A-C10orf112


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FRMD4Achr1013735897-C10orf112chr1019780445+0.0009350660.999065
FRMD4Achr1013735897-C10orf112chr1019780445+0.0009350660.999065

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FRMD4A-C10orf112


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:13735898/chr10:19780446)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFRMD4Achr10:13735898chr10:19780446ENST00000357447-152520_3223722034.0DomainFERM
HgeneFRMD4Achr10:13735898chr10:19780446ENST00000378503-142320_3223721040.0DomainFERM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFRMD4Achr10:13735898chr10:19780446ENST00000357447-1525382_4163722034.0Coiled coilOntology_term=ECO:0000255
HgeneFRMD4Achr10:13735898chr10:19780446ENST00000378503-1423382_4163721040.0Coiled coilOntology_term=ECO:0000255
HgeneFRMD4Achr10:13735898chr10:19780446ENST00000357447-1525627_7563722034.0Compositional biasNote=Ser-rich
HgeneFRMD4Achr10:13735898chr10:19780446ENST00000357447-1525935_10073722034.0Compositional biasNote=Ser-rich
HgeneFRMD4Achr10:13735898chr10:19780446ENST00000378503-1423627_7563721040.0Compositional biasNote=Ser-rich
HgeneFRMD4Achr10:13735898chr10:19780446ENST00000378503-1423935_10073721040.0Compositional biasNote=Ser-rich


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Fusion Gene Sequence for FRMD4A-C10orf112


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31322_31322_1_FRMD4A-C10orf112_FRMD4A_chr10_13735898_ENST00000357447_C10orf112_chr10_19780446_ENST00000454679_length(transcript)=3020nt_BP=1486nt
GAACGCTCACAGAACAGGCAGTGCAATTCCATGTTCCTCTTAAGTATGTTAGCCCTACCGGGAGCTGAGCTGGCCAGTCTACTTGGAGAG
GAAAAGTAGATCTGGGGAAGGTGGAAGGGTCAGTTCCTAAGTGACTTCCTCCTCGGGGATGGTAAGGGCATTTGCTGATCTCCAGTGACT
GCCTGGTGCCTCATGGTCAGACTCGGCTGTCTCACTCCCAGATATCTGATTTTGCAAAAAGGGACACACCTATCTGCAGCAAAGAAGACA
CTGACCAGATTGCGAGCGGTGCTTTTGGATGCTCTGTAGCCACCCGGGGCCCAGGAGGACTGACTCGGCAGCAGGATTCGTGCATGGGAA
TCGGAGACCATGGCAGTGCAGCTGGTGCCCGACTCAGCTCTCGGCCTGCTGATGATGACGGAGGGCCGCCGATGTCAAGTACATCTTCTT
GATGACAGGAAGCTGGAACTCCTAGTACAGCCCAAGCTGTTGGCCAAGGAGCTTCTTGACCTTGTGGCTTCTCACTTCAATCTGAAGGAA
AAGGAGTACTTTGGAATAGCATTCACAGATGAAACGGGACACTTAAACTGGCTTCAGCTAGATCGAAGAGTATTGGAACATGACTTCCCT
AAAAAGTCAGGACCCGTGGTTTTATACTTTTGTGTCAGGTTCTATATAGAAAGCATTTCATACCTGAAGGATAATGCTACCATTGAGCTT
TTCTTTCTGAACGCGAAGTCCTGCATCTACAAGGAGCTTATTGACGTTGACAGCGAAGTGGTGTTTGAATTAGCTTCCTATATTTTACAG
GAGGCAAAGGGAGATTTTTCTAGCAATGAAGTTGTGAGGAGTGACTTGAAGAAGCTGCCAGCCCTTCCCACCCAAGCCCTGAAGGAGCAC
CCTTCCCTGGCCTACTGTGAAGACAGAGTCATTGAGCACTACAAGAAACTGAACGGTCAGACAAGAGGTCAAGCAATCGTAAACTACATG
AGCATCGTGGAGTCTCTCCCAACCTACGGGGTTCACTATTATGCAGTGAAGGACAAGCAGGGCATACCATGGTGGCTGGGCCTGAGCTAC
AAAGGGATCTTCCAGTATGACTACCATGATAAAGTGAAGCCAAGAAAGATATTCCAATGGAGACAGTTGGAAAACCTGTACTTCAGAGAA
AAGAAGTTTTCCGTGGAAGTTCATGACCCACGCAGGGCTTCAGTGACAAGGAGGACGTTTGGGCACAGCGGCATTGCAGTGCACACGTGG
TATGCATGTCCGGCATTGATCAAGTCCATCTGGGCTATGGCCATAAGCCAACACCAGTTCTATCTGGACAGAAAGCAGAGTAAGTCCAAA
ATCCATGCAGCACGCAGCCTGAGTGAGATCGCCATCGACCTGACCGAGACGGGGACGCTGAAGACCTCGAAGCTGGCCAACATGGGTAGC
AAGGGGAAGATCATCAGCGGCAGCAGCGGCAGCCTGCTGTCTTCAGTGGGAGAGATCTCTGAGCTTTGTCCGGAAATCACTGATTTTTTG
TGCCGGGACAAGAAGTGCATTGCATCCCACCTTCTTTGTGACTATAAGCCAGACTGCTCTGATAGGTCTGATGAAGCTCACTGTGCACAT
TATACAAGCACAACAGGAAGCTGCAATTTTGAAACAAGTTCAGGAAACTGGACCACAGCCTGCAGTCTTACTCAAGACTCTGAGGATGAC
TTGGACTGGGCCATTGGCAGCAGAATTCCTGCCAAAGCATTAATTCCAGACTCTGATCACACGCCAGGTAGTGGTCAGCACTTCCTGTAC
GTCAACTCATCTGGCTCCAAGGAAGGATCCGTTGCCAGAATTACTACTTCCAAATCCTTCCCAGCAAGCCTTGGAATGTGTACTGTTCGG
TTCTGGTTCTACATGATTGATCCCAGGAGTATGGGAATATTAAAGGTGTATACCATTGAAGAATCGGGGCTAAACATCCTGGTGTGGTCA
GTGATTGGAAATAAAAGAACGGGATGGACATATGGCTCTGTGCCTCTCTCCAGTAACAGTCCGTTTAAGGTGGCATTTGAAGCTGATTTG
GATGGAAATGAGGACATCTTTATTGCTCTTGATGACATCTCTTTTACCCCAGAGTGTGTGACTGGAGGTCCTGTCCCAGTGCAGCCATCA
CCCTGTGAAGCTGATCAGTTTTCTTGTATCTACACACTCCAATGTGTCCCTCTCTCAGGGAAATGTGATGGACATGAAGACTGCATAGAT
GGATCTGATGAAATGGATTGTCCTCTCAGCCCCACCCCTCCACTCTGTAGTAACATGGAGTTCCCGTGCTCTACAGACGAGTGTATACCT
TCCCTCCTGCTATGCGATGGAGTGCCCGACTGCCACTTTAATGAAGATGAGCTCATCTGCTCCAACAAAAGCTGTTCTAATGGAGCTCTG
GTGTGTGCCTCCTCCAACAGCTGTATCCCAGCCCACCAGCGCTGTGATGGTTTTGCCGACTGCATGGATTTCCAGCTTGATGAGTCCAGC
TGCTCCGATACATGGACTCTCCTGGGTATTGGATTAGCATTCCTGATGACTCACATCACAGTTGCAGTCTTGTGTTTTCTTGCAAACAGA
AAGGTACCAATAAGGAAAACCGAGGGAAGTGGTAACTGTGCCTTTGTCAATCCAGTTTACGGGAACTGGAGCAACCCAGAGAAAACAGAG
AGTTCTGTCTATTCCTTCTCAAACCCATTATATGGCACAACATCAGGAAGCCTGGAGACCCTGTCACATCATCTCAAATAGCAGCATCGA
GACCAAGTCTGATCCAACATGTGTAGTTTCTAGAAAATTGAAGTCTCCACAATCTGATAGAAACTCATCTTCTACAATGGTAAAAAGAGA
AAGGATTGTAAATGCCAGTGTAATTATAACATTTATGAATGAATTTTCTTGCAGAATATAGAGAATGTTTATATGGAATCAGAATCAGTA

>31322_31322_1_FRMD4A-C10orf112_FRMD4A_chr10_13735898_ENST00000357447_C10orf112_chr10_19780446_ENST00000454679_length(amino acids)=803AA_BP=370
MAVQLVPDSALGLLMMTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPKKS
GPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSL
AYCEDRVIEHYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFREKKF
SVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGK
IISGSSGSLLSSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLTQDSEDDLDW
AIGSRIPAKALIPDSDHTPGSGQHFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIG
NKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSD
EMDCPLSPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSCSD

--------------------------------------------------------------
>31322_31322_2_FRMD4A-C10orf112_FRMD4A_chr10_13735898_ENST00000378503_C10orf112_chr10_19780446_ENST00000454679_length(transcript)=2651nt_BP=1117nt
ATGGCAGTGCAGCTGGTGCCCGACTCAGCTCTCGGCCTGCTGATGATGACGGAGGGCCGCCGATGTCAAGTACATCTTCTTGATGACAGG
AAGCTGGAACTCCTAGTACAGCCCAAGCTGTTGGCCAAGGAGCTTCTTGACCTTGTGGCTTCTCACTTCAATCTGAAGGAAAAGGAGTAC
TTTGGAATAGCATTCACAGATGAAACGGGACACTTAAACTGGCTTCAGCTAGATCGAAGAGTATTGGAACATGACTTCCCTAAAAAGTCA
GGACCCGTGGTTTTATACTTTTGTGTCAGGTTCTATATAGAAAGCATTTCATACCTGAAGGATAATGCTACCATTGAGCTTTTCTTTCTG
AACGCGAAGTCCTGCATCTACAAGGAGCTTATTGACGTTGACAGCGAAGTGGTGTTTGAATTAGCTTCCTATATTTTACAGGAGGCAAAG
GGAGATTTTTCTAGCAATGAAGTTGTGAGGAGTGACTTGAAGAAGCTGCCAGCCCTTCCCACCCAAGCCCTGAAGGAGCACCCTTCCCTG
GCCTACTGTGAAGACAGAGTCATTGAGCACTACAAGAAACTGAACGGTCAGACAAGAGGTCAAGCAATCGTAAACTACATGAGCATCGTG
GAGTCTCTCCCAACCTACGGGGTTCACTATTATGCAGTGAAGGACAAGCAGGGCATACCATGGTGGCTGGGCCTGAGCTACAAAGGGATC
TTCCAGTATGACTACCATGATAAAGTGAAGCCAAGAAAGATATTCCAATGGAGACAGTTGGAAAACCTGTACTTCAGAGAAAAGAAGTTT
TCCGTGGAAGTTCATGACCCACGCAGGGCTTCAGTGACAAGGAGGACGTTTGGGCACAGCGGCATTGCAGTGCACACGTGGTATGCATGT
CCGGCATTGATCAAGTCCATCTGGGCTATGGCCATAAGCCAACACCAGTTCTATCTGGACAGAAAGCAGAGTAAGTCCAAAATCCATGCA
GCACGCAGCCTGAGTGAGATCGCCATCGACCTGACCGAGACGGGGACGCTGAAGACCTCGAAGCTGGCCAACATGGGTAGCAAGGGGAAG
ATCATCAGCGGCAGCAGCGGCAGCCTGCTGTCTTCAGTGGGAGAGATCTCTGAGCTTTGTCCGGAAATCACTGATTTTTTGTGCCGGGAC
AAGAAGTGCATTGCATCCCACCTTCTTTGTGACTATAAGCCAGACTGCTCTGATAGGTCTGATGAAGCTCACTGTGCACATTATACAAGC
ACAACAGGAAGCTGCAATTTTGAAACAAGTTCAGGAAACTGGACCACAGCCTGCAGTCTTACTCAAGACTCTGAGGATGACTTGGACTGG
GCCATTGGCAGCAGAATTCCTGCCAAAGCATTAATTCCAGACTCTGATCACACGCCAGGTAGTGGTCAGCACTTCCTGTACGTCAACTCA
TCTGGCTCCAAGGAAGGATCCGTTGCCAGAATTACTACTTCCAAATCCTTCCCAGCAAGCCTTGGAATGTGTACTGTTCGGTTCTGGTTC
TACATGATTGATCCCAGGAGTATGGGAATATTAAAGGTGTATACCATTGAAGAATCGGGGCTAAACATCCTGGTGTGGTCAGTGATTGGA
AATAAAAGAACGGGATGGACATATGGCTCTGTGCCTCTCTCCAGTAACAGTCCGTTTAAGGTGGCATTTGAAGCTGATTTGGATGGAAAT
GAGGACATCTTTATTGCTCTTGATGACATCTCTTTTACCCCAGAGTGTGTGACTGGAGGTCCTGTCCCAGTGCAGCCATCACCCTGTGAA
GCTGATCAGTTTTCTTGTATCTACACACTCCAATGTGTCCCTCTCTCAGGGAAATGTGATGGACATGAAGACTGCATAGATGGATCTGAT
GAAATGGATTGTCCTCTCAGCCCCACCCCTCCACTCTGTAGTAACATGGAGTTCCCGTGCTCTACAGACGAGTGTATACCTTCCCTCCTG
CTATGCGATGGAGTGCCCGACTGCCACTTTAATGAAGATGAGCTCATCTGCTCCAACAAAAGCTGTTCTAATGGAGCTCTGGTGTGTGCC
TCCTCCAACAGCTGTATCCCAGCCCACCAGCGCTGTGATGGTTTTGCCGACTGCATGGATTTCCAGCTTGATGAGTCCAGCTGCTCCGAT
ACATGGACTCTCCTGGGTATTGGATTAGCATTCCTGATGACTCACATCACAGTTGCAGTCTTGTGTTTTCTTGCAAACAGAAAGGTACCA
ATAAGGAAAACCGAGGGAAGTGGTAACTGTGCCTTTGTCAATCCAGTTTACGGGAACTGGAGCAACCCAGAGAAAACAGAGAGTTCTGTC
TATTCCTTCTCAAACCCATTATATGGCACAACATCAGGAAGCCTGGAGACCCTGTCACATCATCTCAAATAGCAGCATCGAGACCAAGTC
TGATCCAACATGTGTAGTTTCTAGAAAATTGAAGTCTCCACAATCTGATAGAAACTCATCTTCTACAATGGTAAAAAGAGAAAGGATTGT
AAATGCCAGTGTAATTATAACATTTATGAATGAATTTTCTTGCAGAATATAGAGAATGTTTATATGGAATCAGAATCAGTACCTTATCTT

>31322_31322_2_FRMD4A-C10orf112_FRMD4A_chr10_13735898_ENST00000378503_C10orf112_chr10_19780446_ENST00000454679_length(amino acids)=803AA_BP=370
MAVQLVPDSALGLLMMTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPKKS
GPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSL
AYCEDRVIEHYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFREKKF
SVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGK
IISGSSGSLLSSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLTQDSEDDLDW
AIGSRIPAKALIPDSDHTPGSGQHFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIG
NKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSD
EMDCPLSPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSCSD

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Fusion Gene PPI Analysis for FRMD4A-C10orf112


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FRMD4A-C10orf112


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FRMD4A-C10orf112


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFRMD4AC4225193CORPUS CALLOSUM, AGENESIS OF, WITH FACIAL ANOMALIES AND CEREBELLAR ATAXIA2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneFRMD4AC0013146Drug abuse1CTD_human
HgeneFRMD4AC0013170Drug habituation1CTD_human
HgeneFRMD4AC0013222Drug Use Disorders1CTD_human
HgeneFRMD4AC0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneFRMD4AC0038580Substance Dependence1CTD_human
HgeneFRMD4AC0038586Substance Use Disorders1CTD_human
HgeneFRMD4AC0236969Substance-Related Disorders1CTD_human
HgeneFRMD4AC0740858Substance abuse problem1CTD_human
HgeneFRMD4AC1510472Drug Dependence1CTD_human
HgeneFRMD4AC4316881Prescription Drug Abuse1CTD_human