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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CEP72-AHRR (FusionGDB2 ID:HG55722TG57491)

Fusion Gene Summary for CEP72-AHRR

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP72-AHRR
Fusion gene ID: hg55722tg57491
HgeneTgene
Gene symbol

CEP72

AHRR

Gene ID

55722

57491

Gene namecentrosomal protein 72aryl-hydrocarbon receptor repressor
Synonyms-AHH|AHHR|bHLHe77
Cytomap('CEP72')('AHRR')

5p15.33

5p15.33

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 72 kDacentrosomal protein 72kDaaryl hydrocarbon receptor repressorahR repressoraryl hydrocarbon hydroxylase regulatorclass E basic helix-loop-helix protein 77dioxin receptor repressor
Modification date2020032720200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264935, ENST00000444221, 
ENST00000514507, 
Fusion gene scores* DoF score7 X 5 X 5=1757 X 6 X 4=168
# samples 89
** MAII scorelog2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CEP72 [Title/Abstract] AND AHRR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCEP72(624694)-AHRR(344008), # samples:1
Anticipated loss of major functional domain due to fusion event.CEP72-AHRR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CEP72-AHRR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CEP72 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across AHRR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-8277-01ACEP72chr5

624694

-AHRRchr5

344008

+


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Fusion Gene ORF analysis for CEP72-AHRR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000264935ENST00000512529CEP72chr5

624694

-AHRRchr5

344008

+
5CDS-5UTRENST00000264935ENST00000515206CEP72chr5

624694

-AHRRchr5

344008

+
5CDS-5UTRENST00000444221ENST00000512529CEP72chr5

624694

-AHRRchr5

344008

+
5CDS-5UTRENST00000444221ENST00000515206CEP72chr5

624694

-AHRRchr5

344008

+
5CDS-intronENST00000264935ENST00000506456CEP72chr5

624694

-AHRRchr5

344008

+
5CDS-intronENST00000444221ENST00000506456CEP72chr5

624694

-AHRRchr5

344008

+
In-frameENST00000264935ENST00000316418CEP72chr5

624694

-AHRRchr5

344008

+
In-frameENST00000264935ENST00000505113CEP72chr5

624694

-AHRRchr5

344008

+
In-frameENST00000444221ENST00000316418CEP72chr5

624694

-AHRRchr5

344008

+
In-frameENST00000444221ENST00000505113CEP72chr5

624694

-AHRRchr5

344008

+
intron-3CDSENST00000514507ENST00000316418CEP72chr5

624694

-AHRRchr5

344008

+
intron-3CDSENST00000514507ENST00000505113CEP72chr5

624694

-AHRRchr5

344008

+
intron-5UTRENST00000514507ENST00000512529CEP72chr5

624694

-AHRRchr5

344008

+
intron-5UTRENST00000514507ENST00000515206CEP72chr5

624694

-AHRRchr5

344008

+
intron-intronENST00000514507ENST00000506456CEP72chr5

624694

-AHRRchr5

344008

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264935CEP72chr5624694-ENST00000505113AHRRchr5344008+2729602902705871
ENST00000264935CEP72chr5624694-ENST00000316418AHRRchr5344008+6217602902759889
ENST00000444221CEP72chr5624694-ENST00000505113AHRRchr5344008+2711584722687871
ENST00000444221CEP72chr5624694-ENST00000316418AHRRchr5344008+6199584722741889

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264935ENST00000505113CEP72chr5624694-AHRRchr5344008+0.0224521440.9775479
ENST00000264935ENST00000316418CEP72chr5624694-AHRRchr5344008+0.0067881830.99321175
ENST00000444221ENST00000505113CEP72chr5624694-AHRRchr5344008+0.0220004130.9779996
ENST00000444221ENST00000316418CEP72chr5624694-AHRRchr5344008+0.0067138790.9932861

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Fusion Genomic Features for CEP72-AHRR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CEP72-AHRR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:624694/chr5:344008)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP72chr5:624694chr5:344008ENST00000264935-412111_150170648.0DomainNote=LRRCT
HgeneCEP72chr5:624694chr5:344008ENST00000444221-411111_150170306.3333333333333DomainNote=LRRCT
HgeneCEP72chr5:624694chr5:344008ENST00000264935-41229_50170648.0RepeatNote=LRR 1
HgeneCEP72chr5:624694chr5:344008ENST00000264935-41255_76170648.0RepeatNote=LRR 2
HgeneCEP72chr5:624694chr5:344008ENST00000264935-41277_98170648.0RepeatNote=LRR 3
HgeneCEP72chr5:624694chr5:344008ENST00000444221-41129_50170306.3333333333333RepeatNote=LRR 1
HgeneCEP72chr5:624694chr5:344008ENST00000444221-41155_76170306.3333333333333RepeatNote=LRR 2
HgeneCEP72chr5:624694chr5:344008ENST00000444221-41177_98170306.3333333333333RepeatNote=LRR 3
TgeneAHRRchr5:624694chr5:344008ENST00000316418012112_1820720.0DomainPAS
TgeneAHRRchr5:624694chr5:344008ENST0000031641801228_810720.0DomainbHLH
TgeneAHRRchr5:624694chr5:344008ENST00000505113011112_1820702.0DomainPAS
TgeneAHRRchr5:624694chr5:344008ENST0000050511301128_810702.0DomainbHLH
TgeneAHRRchr5:624694chr5:344008ENST00000316418012551_7010720.0RegionNeeded for transcriptional repression
TgeneAHRRchr5:624694chr5:344008ENST00000505113011551_7010702.0RegionNeeded for transcriptional repression

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP72chr5:624694chr5:344008ENST00000264935-412476_620170648.0Coiled coilOntology_term=ECO:0000255
HgeneCEP72chr5:624694chr5:344008ENST00000444221-411476_620170306.3333333333333Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for CEP72-AHRR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15889_15889_1_CEP72-AHRR_CEP72_chr5_624694_ENST00000264935_AHRR_chr5_344008_ENST00000316418_length(transcript)=6217nt_BP=602nt
GGCTCTCGGTTCTGCCGACGCAGGTCCCGCCCCTCTCGTAGCCTCGCCCCGCCCGCCGCGCAGGCGCCGTCCGAGGGCTCCGTTTGAAAC
ATGGCGCGGGCTGGCCCTCGGCTGGTGCTGAGCGAGGAGGCGGTTCGGGCGAAGAGCGGCTTAGGGCCTCACCGCGACCTGGCTGAGCTT
CAGTCATTGTCTATTCCTGGAACTTACCAAGAGAAGATCACCCACCTGGGACATTCTCTGATGAGTTTAACAGGTCTGAAATCTTTGGAT
CTCTCGCGCAACTCCTTGGTTAGTCTGGAGGGCATTCAGTACCTGACTGCATTGGAGAGTCTCAATCTCTACTACAACTGCATCTCCTCG
TTGGCAGAAGTGTTTCGGCTCCACGCCTTAACCGAGCTCGTGGATGTGGACTTCCGGCTGAACCCCGTGGTGAAGGTTGAGCCTGACTAC
CGCCTTTTTGTTGTGCACCTGCTCCCCAAGCTCCAGCAGCTGGACGATCGCCCCGTGAGAGCAAGCGAGCGGAAGGCTTCCCGACTGCAT
TTTGCATCAGAGGACTCACTCGACTCCAAAGAGAGCGTCCCAGCTTCTTTGAAAGAGGGCAGGCCGAGGACGATGATCCCGCCGGGGGAG
TGCACGTACGCGGGCCGGAAGCGGAGGAGGCCCCTGCAGAAACAGAGGCCCGCCGTGGGGGCAGAGAAGTCCAACCCCTCCAAGCGACAC
CGGGACCGCCTCAACGCCGAGTTGGACCACCTGGCCAGCCTGCTGCCGTTCCCGCCTGACATCATCTCCAAGCTGGACAAGCTTTCTGTC
CTGCGCCTCAGTGTCAGTTACCTCCGGGTGAAGAGCTTCTTCCAAGTCGTGCAGGAGCAGAGCTCACGGCAGCCTGCGGCCGGCGCCCCC
TCGCCCGGAGACAGCTGTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGTCTCTTAATGGCTTTGCTCTGGTCGTG
AGTGCAGAAGGGACGATATTTTATGCATCAGCAACGATCGTGGACTATCTGGGCTTCCATCAGACGGATGTAATGCACCAGAACATTTAT
GACTACATCCACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCG
CCCTTGGAGACAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTC
CTGACCCGCTGCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGGCCCGGGGGTCACAGGCTTGGCAGCTGCGG
CTCTGCTGTCCCGAGCCACTCATGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCCGTCAGGAGCC
ATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAGCGCGCTCCTG
AGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACTGCATGGAAAA
CCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGCACAGGTTCCC
GCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGAGGAGCAGCAC
AGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGGAAAGCACAGT
GAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCTGCCCTGCCCG
TGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAGCAGACCCATG
CGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCCTGGAGCTCAG
CGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCCGACGCTGCTG
CTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCTGGGGGCCAGT
GACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTGTACATCTCGCACCTGGGG
CACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACACTGTGCCTGC
CTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCACCTGCAGAGCT
GCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGGGATGTTGCCC
AAAAGTGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATAGCGCAGTGACCACCATCCAAGCTCAGATCTG
TGTGTCTACGCTCAGATGCGTCGGTGGCTGGGCTGCCCTGCTCCTGGTCAGGCCGGAGCCCGTCCTAAGACACACGCTTTGCAGAGCTGT
GCATGCGCAGTCTGCTAGTGTGTGTGTGCAGCATACGCAGGAGCCTATCCTGAATTTTGTAAAATATCCCAACAGTTCTTAAATGAAAAC
TGGCCTTAAGTCTATTCAAGCATGACAGCATTTCTCTTTGAGGAATTAAAATCTTTAGGAAAGTGATCATGGCTGGACAGCTTCATGCCC
CAGAGGCAGCGAGCACCCGTCCCATGGCTGCCAAGTCCACAGTCGGGGATGAAGCAGTCGGGTGATGCTCCCAAGTCCGCAGTCGGGGAT
GAAGCGGTCGGGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCGGGTGACACACCTAGCTCAGCCCTCCCAGGCCACCTGCAGC
TCCCAGCCTGTGCTGTGCAGGCAGGGTCAGCCCATCGCCACAGTGCACTGTAGAGGCCAGCACACGGCAAATTAGAAATACAACACGCGG
AGAAAGGGGTCCGTGAGCCCACTCATAGAGGAATCTAGAACGTTCCAGGCAGCAGAGGCTGGCAGCGTGGGTCCCACACTGCCCCACACC
GTGCGGCAGGTGCTCCATGGCGCCATGACAGAGTCTGAGGCCAGACCTGGACTGGAATTGACAGCATAACCCCTGTTCCTTCTGGACATC
TCCCGAGTTCTCAGTGGGTCTCTGCGGACGGTTCTTCCTAATCTGCCTCTTGGTACATCACGTAATACAGAGTTCACAGACTCCGGGTTT
GGAAGTACAGAGAAACACACAACGTAGAGAGAAGACACAGGAAACTGCGCTGCCTGTGGGGGTTTCTCTCTGGCTGGCTGTACAGTTCAC
TCAAATGAGGGTTCCCATTGCCATCCTAGGAGAATAATTAGGGACAAGACAGACAAGTATTAATAGCATTAAAACAGTTGTAAAGGCGAT
ATTTTCTGAGAGTAGGAAATTTGGATACAAAAGCATAAGTCAGAAAGTGAAGGTCACCAATCCACCAACCCGAGAACCTACAGCTGATGG
TGCATTTCAGGCTTCTTCCACGGTCTGGCCTGGAACCCCACCCGGCTGGTGCAGGCATCAGATCAGGGTGTAGAAGTCACCCCAAGCAAG
AGGAAGCCAGGCAGTGAGGCCCTGGGGTGTGGCTGCAGCTGGGCCCACCTGTGCGGGGGTGGGAAGGCCCCATCCTCAGGGAGAGGGCAT
CGGCGCCCTGACGTCAGCTCCACTGGGAGTGGCAGGAGCTGTGGGAGCCCATGGGTGAGGGACCCACCACCCCGCTGCACTGTGCATTGT
GCCTCCCGTGTGGACGCCCTCTCTGTTGTTGGCCCGCGGGTGAGGGACCCACCACCCCTAGGGACCCACCACCCCGCCGCACTGTGCATT
CTGCCTCCTGTGTGGACGCCCTCTCTGTTGTCAGTGGCTTTGAGGTGTCAGTGCTTACTTAGATGCTGGTTTAATGCTGGACCCATTTGT
TAAACGCACCTTCACTTTGTCAAAACCCAGGTTTGGTTGGCAGGACTGGGTCTTCTGCCCAATGCCAGGTGCCTGCGCCTCTCAGTGGCC
TGGTTCTTGGACAGTTTGCCCCCATGTGGCAGGGATAGGGATAAGGATCTCCTCTCAGTACTGGAAGAGAACAGCCAACCATCTGAGCCC
AGAGTCACAGATCCATCGTGGCCCCCTATGACCCCCAAGCCCTACCGAGGGGGCACTCACTCTCTGCTTAGCCAGGGGGCGTCTTTCAAA
AGGTGACCTCCATGCTGTGCTGTCGTGGGTGTGAGACGTGCTCATGGCCTTCCACTGCCATCTCTCCCTTATCTGATGCCTAAAGTCACG
ATGGGGACAGAGCTACCCAGGGGCCAGCCATGGGGTGACCAGCCACCTGAGGGTCAGTCACCTGTGGAGAGCAGGCACCTGTGAAGACCA
GGCACCTGAGGACTGGCGCCTACTTCCCACTTTGGCCCTACACTGGCACAGAGCCCCTCTTTATTCATTTCTCATGCTGAGCATGGCACA
CTTCTGGCCTCTGGGCATTTATGGATTTAAGACCAGGATGGTATTTCAGAAGCTTCCCACTTCCTTCCTATTCTAACCGAGTGCCCAGCT
CCTTTGCTGATCATGGAAAGACCCTTAATAATTAGGCCTGCAGGCCAGGCGCAGTGGCTCATGCCTATAATCCCAGCACTTTAGGAGGTC
AAGGTAGGAGGATCGCTTAAGCCCAGGAGTTCAAGACCAGCCTGGGCAACACAGGAAGAATGTGTCTCTACAAAAAATAATTAAAAATCA
GATCTGCTGTATCCCTGAAAAAGTCTCAATCAACATGCATGTTCCACTCTTGGAGTTCCCTGTTCTGAGGGCCAGCCACGTCCTGTGTCC
TGGAGCTTAGCCCTCAGCAGCTCCCTTCAGCCTGGGCGCCGCCTGGGTCCCAAACGTGGCAGCTGCTCTTCCAGTCTCGGGGCCGAGGAG
GGCAGGGAGCTCAGTGACTGAGAGTCTTGTGTATCACATGTCTTGAGTGTCCTGGAGCCAACGGCTGTCACTGGGAAAAACACCAGGCCC
CAAAGATCGAATCAGAGACGTGGCTGCGTGTTTGCGATTGTAGCCAGGCCCTTCAGTGTCATCAAAGGAGCACTGGGGCCTCCTTAAGCA
CAGACGGCAGCCCCTGCCCAGGAGGCTTCTTCACCACGTCCTGCCCTGCAGCCTCCCAGACCTTTAGATGCGCCCCTGCCCAAGGCCCTC
CTGGTGACAGGTGCCAGATTGAGTGGTGGGTTGCTGCCAGGCAGGCCACGCTGTGTTGACGCTGCACTCAGCACGTGGGTGTTGGCTCTG
CCGGTTTTGTGGTGTGGGGACCCTACAGGAGGCTGCGGCCCTGAGAGCCTGGGATCAGCGAGGTGTCCGACATCCCTTCCTCAACGGCAA
CAAAAACTCCCCAAGTCAGCACTTTGGTTATTTTATAGCCACAACCCTCTTGGAAAACAGTGGGGAAGACTATGGAACATAGAAAGTGTG
GATGTATCACTTCTCTCTAAAATGTCATTGTTAGCACTAATTACAGGTTCATGTTTTTCTGTGTATGTAGCTTTTCCCTATATAGCTGAA
AAAGTATTAAAGTCAAATATAAGGTGGGAATGGGATGGAAGGGAGGAGATCAATACAACTTATATTTTTGCAGTTTCTACTGGAAGAAAA
AAGTTTTCAATACCTAGACCAACTTGTTGAATTTTTAAAACTTATGCACTATAAATGCAACTTTCTCTACTGCTTTCTCAGTGCCTTTAG
GAAGCTTTCAAATTTTTTTGTACTGTGGTTTGTATTAAATTTGCAATATTGATGTAAAATACATGACATGCTAGTACATGTTTAACAAAA
ATTTAAA

>15889_15889_1_CEP72-AHRR_CEP72_chr5_624694_ENST00000264935_AHRR_chr5_344008_ENST00000316418_length(amino acids)=889AA_BP=170
MARAGPRLVLSEEAVRAKSGLGPHRDLAELQSLSIPGTYQEKITHLGHSLMSLTGLKSLDLSRNSLVSLEGIQYLTALESLNLYYNCISS
LAEVFRLHALTELVDVDFRLNPVVKVEPDYRLFVVHLLPKLQQLDDRPVRASERKASRLHFASEDSLDSKESVPASLKEGRPRTMIPPGE
CTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQSSRQPAAGAP
SPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPP
PLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRVRCLLDSTSGFLARGSQAWQLRLCCPEPLMTMQFQGKLKFLFGQKKKAPSGA
MLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVP
ARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLSRASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCP
CVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLL
LDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCAC
LEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAAPVVKREPLDSPQWATHSQGMVPGMLPKSALATLVPPQASGCTFLP

--------------------------------------------------------------
>15889_15889_2_CEP72-AHRR_CEP72_chr5_624694_ENST00000264935_AHRR_chr5_344008_ENST00000505113_length(transcript)=2729nt_BP=602nt
GGCTCTCGGTTCTGCCGACGCAGGTCCCGCCCCTCTCGTAGCCTCGCCCCGCCCGCCGCGCAGGCGCCGTCCGAGGGCTCCGTTTGAAAC
ATGGCGCGGGCTGGCCCTCGGCTGGTGCTGAGCGAGGAGGCGGTTCGGGCGAAGAGCGGCTTAGGGCCTCACCGCGACCTGGCTGAGCTT
CAGTCATTGTCTATTCCTGGAACTTACCAAGAGAAGATCACCCACCTGGGACATTCTCTGATGAGTTTAACAGGTCTGAAATCTTTGGAT
CTCTCGCGCAACTCCTTGGTTAGTCTGGAGGGCATTCAGTACCTGACTGCATTGGAGAGTCTCAATCTCTACTACAACTGCATCTCCTCG
TTGGCAGAAGTGTTTCGGCTCCACGCCTTAACCGAGCTCGTGGATGTGGACTTCCGGCTGAACCCCGTGGTGAAGGTTGAGCCTGACTAC
CGCCTTTTTGTTGTGCACCTGCTCCCCAAGCTCCAGCAGCTGGACGATCGCCCCGTGAGAGCAAGCGAGCGGAAGGCTTCCCGACTGCAT
TTTGCATCAGAGGACTCACTCGACTCCAAAGAGAGCGTCCCAGCTTCTTTGAAAGAGGGCAGGCCGAGGACGATGATCCCGCCGGGGGAG
TGCACGTACGCGGGCCGGAAGCGGAGGAGGCCCCTGCAGAAACAGAGGCCCGCCGTGGGGGCAGAGAAGTCCAACCCCTCCAAGCGACAC
CGGGACCGCCTCAACGCCGAGTTGGACCACCTGGCCAGCCTGCTGCCGTTCCCGCCTGACATCATCTCCAAGCTGGACAAGCTTTCTGTC
CTGCGCCTCAGTGTCAGTTACCTCCGGGTGAAGAGCTTCTTCCAAGTCGTGCAGGAGCAGAGCTCACGGCAGCCTGCGGCCGGCGCCCCC
TCGCCCGGAGACAGCTGTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGTCTCTTAATGGCTTTGCTCTGGTCGTG
AGTGCAGAAGGGACGATATTTTATGCATCAGCAACGATCGTGGACTATCTGGGCTTCCATCAGACGGATGTAATGCACCAGAACATTTAT
GACTACATCCACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCG
CCCTTGGAGACAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTC
CTGACCCGCTGCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGACGATGCAGTTTCAAGGAAAACTAAAATTC
CTGTTTGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCC
TCCGCAGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCC
ACCACCAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGG
GAACAGACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCC
AAGGGGGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCC
ACAAAGCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTG
CGCCCCATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCC
CCCAGTGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGG
AGCCTGCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCG
ATGCCTCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGAC
GGCTGTGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCA
GACTCTCGGCAACAGGTGTACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGG
GAGCTGACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCA
CGGGGCCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCT
ACTCACAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTG
CCATAGCGCAGTGACCACCATCCAAGCTC

>15889_15889_2_CEP72-AHRR_CEP72_chr5_624694_ENST00000264935_AHRR_chr5_344008_ENST00000505113_length(amino acids)=871AA_BP=170
MARAGPRLVLSEEAVRAKSGLGPHRDLAELQSLSIPGTYQEKITHLGHSLMSLTGLKSLDLSRNSLVSLEGIQYLTALESLNLYYNCISS
LAEVFRLHALTELVDVDFRLNPVVKVEPDYRLFVVHLLPKLQQLDDRPVRASERKASRLHFASEDSLDSKESVPASLKEGRPRTMIPPGE
CTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQSSRQPAAGAP
SPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPP
PLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLP
SAAEMKMRSALLRAKPRADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDP
KGGSGDREEEQHRMLSRASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPS
PSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAAD
GCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCA
RGRGEQSCTCRAAEAAPVVKREPLDSPQWATHSQGMVPGMLPKSALATLVPPQASGCTFLP

--------------------------------------------------------------
>15889_15889_3_CEP72-AHRR_CEP72_chr5_624694_ENST00000444221_AHRR_chr5_344008_ENST00000316418_length(transcript)=6199nt_BP=584nt
CGCAGGTCCCGCCCCTCTCGTAGCCTCGCCCCGCCCGCCGCGCAGGCGCCGTCCGAGGGCTCCGTTTGAAACATGGCGCGGGCTGGCCCT
CGGCTGGTGCTGAGCGAGGAGGCGGTTCGGGCGAAGAGCGGCTTAGGGCCTCACCGCGACCTGGCTGAGCTTCAGTCATTGTCTATTCCT
GGAACTTACCAAGAGAAGATCACCCACCTGGGACATTCTCTGATGAGTTTAACAGGTCTGAAATCTTTGGATCTCTCGCGCAACTCCTTG
GTTAGTCTGGAGGGCATTCAGTACCTGACTGCATTGGAGAGTCTCAATCTCTACTACAACTGCATCTCCTCGTTGGCAGAAGTGTTTCGG
CTCCACGCCTTAACCGAGCTCGTGGATGTGGACTTCCGGCTGAACCCCGTGGTGAAGGTTGAGCCTGACTACCGCCTTTTTGTTGTGCAC
CTGCTCCCCAAGCTCCAGCAGCTGGACGATCGCCCCGTGAGAGCAAGCGAGCGGAAGGCTTCCCGACTGCATTTTGCATCAGAGGACTCA
CTCGACTCCAAAGAGAGCGTCCCAGCTTCTTTGAAAGAGGGCAGGCCGAGGACGATGATCCCGCCGGGGGAGTGCACGTACGCGGGCCGG
AAGCGGAGGAGGCCCCTGCAGAAACAGAGGCCCGCCGTGGGGGCAGAGAAGTCCAACCCCTCCAAGCGACACCGGGACCGCCTCAACGCC
GAGTTGGACCACCTGGCCAGCCTGCTGCCGTTCCCGCCTGACATCATCTCCAAGCTGGACAAGCTTTCTGTCCTGCGCCTCAGTGTCAGT
TACCTCCGGGTGAAGAGCTTCTTCCAAGTCGTGCAGGAGCAGAGCTCACGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCTGT
CCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGTCTCTTAATGGCTTTGCTCTGGTCGTGAGTGCAGAAGGGACGATA
TTTTATGCATCAGCAACGATCGTGGACTATCTGGGCTTCCATCAGACGGATGTAATGCACCAGAACATTTATGACTACATCCACGTGGAC
GACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTTGGAGACAGGAGAT
GATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGACCCGCTGCTTCATC
TGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGGCCCGGGGGTCACAGGCTTGGCAGCTGCGGCTCTGCTGTCCCGAGCCA
CTCATGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTG
TCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCA
GACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAATTACTCAGCAGGA
AGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTG
TGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCC
TCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCG
AGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTC
AGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCGGTGAGGAC
CAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGC
TATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAG
ATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCC
ACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTGTACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCT
CAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGC
CTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTG
GTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACG
CTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATAGCGCAGTGACCACCATCCAAGCTCAGATCTGTGTGTCTACGCTCAGATG
CGTCGGTGGCTGGGCTGCCCTGCTCCTGGTCAGGCCGGAGCCCGTCCTAAGACACACGCTTTGCAGAGCTGTGCATGCGCAGTCTGCTAG
TGTGTGTGTGCAGCATACGCAGGAGCCTATCCTGAATTTTGTAAAATATCCCAACAGTTCTTAAATGAAAACTGGCCTTAAGTCTATTCA
AGCATGACAGCATTTCTCTTTGAGGAATTAAAATCTTTAGGAAAGTGATCATGGCTGGACAGCTTCATGCCCCAGAGGCAGCGAGCACCC
GTCCCATGGCTGCCAAGTCCACAGTCGGGGATGAAGCAGTCGGGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCGGGTGATGC
TCCCAAGTCCGCAGTCGGGGATGAAGCGGTCGGGTGACACACCTAGCTCAGCCCTCCCAGGCCACCTGCAGCTCCCAGCCTGTGCTGTGC
AGGCAGGGTCAGCCCATCGCCACAGTGCACTGTAGAGGCCAGCACACGGCAAATTAGAAATACAACACGCGGAGAAAGGGGTCCGTGAGC
CCACTCATAGAGGAATCTAGAACGTTCCAGGCAGCAGAGGCTGGCAGCGTGGGTCCCACACTGCCCCACACCGTGCGGCAGGTGCTCCAT
GGCGCCATGACAGAGTCTGAGGCCAGACCTGGACTGGAATTGACAGCATAACCCCTGTTCCTTCTGGACATCTCCCGAGTTCTCAGTGGG
TCTCTGCGGACGGTTCTTCCTAATCTGCCTCTTGGTACATCACGTAATACAGAGTTCACAGACTCCGGGTTTGGAAGTACAGAGAAACAC
ACAACGTAGAGAGAAGACACAGGAAACTGCGCTGCCTGTGGGGGTTTCTCTCTGGCTGGCTGTACAGTTCACTCAAATGAGGGTTCCCAT
TGCCATCCTAGGAGAATAATTAGGGACAAGACAGACAAGTATTAATAGCATTAAAACAGTTGTAAAGGCGATATTTTCTGAGAGTAGGAA
ATTTGGATACAAAAGCATAAGTCAGAAAGTGAAGGTCACCAATCCACCAACCCGAGAACCTACAGCTGATGGTGCATTTCAGGCTTCTTC
CACGGTCTGGCCTGGAACCCCACCCGGCTGGTGCAGGCATCAGATCAGGGTGTAGAAGTCACCCCAAGCAAGAGGAAGCCAGGCAGTGAG
GCCCTGGGGTGTGGCTGCAGCTGGGCCCACCTGTGCGGGGGTGGGAAGGCCCCATCCTCAGGGAGAGGGCATCGGCGCCCTGACGTCAGC
TCCACTGGGAGTGGCAGGAGCTGTGGGAGCCCATGGGTGAGGGACCCACCACCCCGCTGCACTGTGCATTGTGCCTCCCGTGTGGACGCC
CTCTCTGTTGTTGGCCCGCGGGTGAGGGACCCACCACCCCTAGGGACCCACCACCCCGCCGCACTGTGCATTCTGCCTCCTGTGTGGACG
CCCTCTCTGTTGTCAGTGGCTTTGAGGTGTCAGTGCTTACTTAGATGCTGGTTTAATGCTGGACCCATTTGTTAAACGCACCTTCACTTT
GTCAAAACCCAGGTTTGGTTGGCAGGACTGGGTCTTCTGCCCAATGCCAGGTGCCTGCGCCTCTCAGTGGCCTGGTTCTTGGACAGTTTG
CCCCCATGTGGCAGGGATAGGGATAAGGATCTCCTCTCAGTACTGGAAGAGAACAGCCAACCATCTGAGCCCAGAGTCACAGATCCATCG
TGGCCCCCTATGACCCCCAAGCCCTACCGAGGGGGCACTCACTCTCTGCTTAGCCAGGGGGCGTCTTTCAAAAGGTGACCTCCATGCTGT
GCTGTCGTGGGTGTGAGACGTGCTCATGGCCTTCCACTGCCATCTCTCCCTTATCTGATGCCTAAAGTCACGATGGGGACAGAGCTACCC
AGGGGCCAGCCATGGGGTGACCAGCCACCTGAGGGTCAGTCACCTGTGGAGAGCAGGCACCTGTGAAGACCAGGCACCTGAGGACTGGCG
CCTACTTCCCACTTTGGCCCTACACTGGCACAGAGCCCCTCTTTATTCATTTCTCATGCTGAGCATGGCACACTTCTGGCCTCTGGGCAT
TTATGGATTTAAGACCAGGATGGTATTTCAGAAGCTTCCCACTTCCTTCCTATTCTAACCGAGTGCCCAGCTCCTTTGCTGATCATGGAA
AGACCCTTAATAATTAGGCCTGCAGGCCAGGCGCAGTGGCTCATGCCTATAATCCCAGCACTTTAGGAGGTCAAGGTAGGAGGATCGCTT
AAGCCCAGGAGTTCAAGACCAGCCTGGGCAACACAGGAAGAATGTGTCTCTACAAAAAATAATTAAAAATCAGATCTGCTGTATCCCTGA
AAAAGTCTCAATCAACATGCATGTTCCACTCTTGGAGTTCCCTGTTCTGAGGGCCAGCCACGTCCTGTGTCCTGGAGCTTAGCCCTCAGC
AGCTCCCTTCAGCCTGGGCGCCGCCTGGGTCCCAAACGTGGCAGCTGCTCTTCCAGTCTCGGGGCCGAGGAGGGCAGGGAGCTCAGTGAC
TGAGAGTCTTGTGTATCACATGTCTTGAGTGTCCTGGAGCCAACGGCTGTCACTGGGAAAAACACCAGGCCCCAAAGATCGAATCAGAGA
CGTGGCTGCGTGTTTGCGATTGTAGCCAGGCCCTTCAGTGTCATCAAAGGAGCACTGGGGCCTCCTTAAGCACAGACGGCAGCCCCTGCC
CAGGAGGCTTCTTCACCACGTCCTGCCCTGCAGCCTCCCAGACCTTTAGATGCGCCCCTGCCCAAGGCCCTCCTGGTGACAGGTGCCAGA
TTGAGTGGTGGGTTGCTGCCAGGCAGGCCACGCTGTGTTGACGCTGCACTCAGCACGTGGGTGTTGGCTCTGCCGGTTTTGTGGTGTGGG
GACCCTACAGGAGGCTGCGGCCCTGAGAGCCTGGGATCAGCGAGGTGTCCGACATCCCTTCCTCAACGGCAACAAAAACTCCCCAAGTCA
GCACTTTGGTTATTTTATAGCCACAACCCTCTTGGAAAACAGTGGGGAAGACTATGGAACATAGAAAGTGTGGATGTATCACTTCTCTCT
AAAATGTCATTGTTAGCACTAATTACAGGTTCATGTTTTTCTGTGTATGTAGCTTTTCCCTATATAGCTGAAAAAGTATTAAAGTCAAAT
ATAAGGTGGGAATGGGATGGAAGGGAGGAGATCAATACAACTTATATTTTTGCAGTTTCTACTGGAAGAAAAAAGTTTTCAATACCTAGA
CCAACTTGTTGAATTTTTAAAACTTATGCACTATAAATGCAACTTTCTCTACTGCTTTCTCAGTGCCTTTAGGAAGCTTTCAAATTTTTT
TGTACTGTGGTTTGTATTAAATTTGCAATATTGATGTAAAATACATGACATGCTAGTACATGTTTAACAAAAATTTAAA

>15889_15889_3_CEP72-AHRR_CEP72_chr5_624694_ENST00000444221_AHRR_chr5_344008_ENST00000316418_length(amino acids)=889AA_BP=170
MARAGPRLVLSEEAVRAKSGLGPHRDLAELQSLSIPGTYQEKITHLGHSLMSLTGLKSLDLSRNSLVSLEGIQYLTALESLNLYYNCISS
LAEVFRLHALTELVDVDFRLNPVVKVEPDYRLFVVHLLPKLQQLDDRPVRASERKASRLHFASEDSLDSKESVPASLKEGRPRTMIPPGE
CTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQSSRQPAAGAP
SPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPP
PLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRVRCLLDSTSGFLARGSQAWQLRLCCPEPLMTMQFQGKLKFLFGQKKKAPSGA
MLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVP
ARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLSRASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCP
CVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLL
LDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCAC
LEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAAPVVKREPLDSPQWATHSQGMVPGMLPKSALATLVPPQASGCTFLP

--------------------------------------------------------------
>15889_15889_4_CEP72-AHRR_CEP72_chr5_624694_ENST00000444221_AHRR_chr5_344008_ENST00000505113_length(transcript)=2711nt_BP=584nt
CGCAGGTCCCGCCCCTCTCGTAGCCTCGCCCCGCCCGCCGCGCAGGCGCCGTCCGAGGGCTCCGTTTGAAACATGGCGCGGGCTGGCCCT
CGGCTGGTGCTGAGCGAGGAGGCGGTTCGGGCGAAGAGCGGCTTAGGGCCTCACCGCGACCTGGCTGAGCTTCAGTCATTGTCTATTCCT
GGAACTTACCAAGAGAAGATCACCCACCTGGGACATTCTCTGATGAGTTTAACAGGTCTGAAATCTTTGGATCTCTCGCGCAACTCCTTG
GTTAGTCTGGAGGGCATTCAGTACCTGACTGCATTGGAGAGTCTCAATCTCTACTACAACTGCATCTCCTCGTTGGCAGAAGTGTTTCGG
CTCCACGCCTTAACCGAGCTCGTGGATGTGGACTTCCGGCTGAACCCCGTGGTGAAGGTTGAGCCTGACTACCGCCTTTTTGTTGTGCAC
CTGCTCCCCAAGCTCCAGCAGCTGGACGATCGCCCCGTGAGAGCAAGCGAGCGGAAGGCTTCCCGACTGCATTTTGCATCAGAGGACTCA
CTCGACTCCAAAGAGAGCGTCCCAGCTTCTTTGAAAGAGGGCAGGCCGAGGACGATGATCCCGCCGGGGGAGTGCACGTACGCGGGCCGG
AAGCGGAGGAGGCCCCTGCAGAAACAGAGGCCCGCCGTGGGGGCAGAGAAGTCCAACCCCTCCAAGCGACACCGGGACCGCCTCAACGCC
GAGTTGGACCACCTGGCCAGCCTGCTGCCGTTCCCGCCTGACATCATCTCCAAGCTGGACAAGCTTTCTGTCCTGCGCCTCAGTGTCAGT
TACCTCCGGGTGAAGAGCTTCTTCCAAGTCGTGCAGGAGCAGAGCTCACGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCTGT
CCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGTCTCTTAATGGCTTTGCTCTGGTCGTGAGTGCAGAAGGGACGATA
TTTTATGCATCAGCAACGATCGTGGACTATCTGGGCTTCCATCAGACGGATGTAATGCACCAGAACATTTATGACTACATCCACGTGGAC
GACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTTGGAGACAGGAGAT
GATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGACCCGCTGCTTCATC
TGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAG
AAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAA
ATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAA
TCGGAACTGCATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGC
CGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGAC
AGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGG
ACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGC
TCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGC
CGGACCAGCAGACCCATGCGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTC
CCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTG
TGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAG
GTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTG
TACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCAC
CCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAG
TCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATG
GTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATAGCGCAGTGACCAC
CATCCAAGCTC

>15889_15889_4_CEP72-AHRR_CEP72_chr5_624694_ENST00000444221_AHRR_chr5_344008_ENST00000505113_length(amino acids)=871AA_BP=170
MARAGPRLVLSEEAVRAKSGLGPHRDLAELQSLSIPGTYQEKITHLGHSLMSLTGLKSLDLSRNSLVSLEGIQYLTALESLNLYYNCISS
LAEVFRLHALTELVDVDFRLNPVVKVEPDYRLFVVHLLPKLQQLDDRPVRASERKASRLHFASEDSLDSKESVPASLKEGRPRTMIPPGE
CTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQSSRQPAAGAP
SPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPP
PLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLP
SAAEMKMRSALLRAKPRADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDP
KGGSGDREEEQHRMLSRASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPS
PSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAAD
GCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCA
RGRGEQSCTCRAAEAAPVVKREPLDSPQWATHSQGMVPGMLPKSALATLVPPQASGCTFLP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CEP72-AHRR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CEP72-AHRR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CEP72-AHRR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource