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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:BDP1-KDM5A (FusionGDB2 ID:HG55814TG5927) |
Fusion Gene Summary for BDP1-KDM5A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BDP1-KDM5A | Fusion gene ID: hg55814tg5927 | Hgene | Tgene | Gene symbol | BDP1 | KDM5A | Gene ID | 55814 | 5927 |
| Gene name | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | lysine demethylase 5A | |
| Synonyms | DFNB112|HSA238520|TAF3B1|TFC5|TFIIIB''|TFIIIB150|TFIIIB90|TFNR | RBBP-2|RBBP2|RBP2 | |
| Cytomap | ('BDP1')('KDM5A') 5q13.2 | 12p13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor TFIIIB component B'' homologRNA polymerase III transcription initiation factor B''TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1transcription factor IIIB 150transcription factor-like nuclear | lysine-specific demethylase 5AJumonji, AT rich interactive domain 1A (RBP2-like)histone demethylase JARID1Ajumonji/ARID domain-containing protein 1Alysine (K)-specific demethylase 5Aretinoblastoma binding protein 2 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000358731, ENST00000380675, | ||
| Fusion gene scores | * DoF score | 8 X 8 X 5=320 | 10 X 11 X 4=440 |
| # samples | 9 | 10 | |
| ** MAII score | log2(9/320*10)=-1.83007499855769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/440*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BDP1 [Title/Abstract] AND KDM5A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | BDP1(70811993)-KDM5A(402303), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | BDP1-KDM5A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BDP1-KDM5A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BDP1-KDM5A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BDP1-KDM5A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | KDM5A | GO:0034720 | histone H3-K4 demethylation | 18270511 |
| Tgene | KDM5A | GO:0045893 | positive regulation of transcription, DNA-templated | 11358960 |
| Fusion gene breakpoints across BDP1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across KDM5A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for BDP1-KDM5A |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000358731 | ENST00000399788 | BDP1 | chr5 | 70811993 | + | KDM5A | chr12 | 402303 | - | 0.000142348 | 0.99985766 |
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Fusion Genomic Features for BDP1-KDM5A |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for BDP1-KDM5A |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:70811993/chr12:402303) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | KDM5A | chr5:70811993 | chr12:402303 | ENST00000399788 | 0 | 28 | 1492_1587 | 0 | 1691.0 | Compositional bias | Note=Lys-rich | |
| Tgene | KDM5A | chr5:70811993 | chr12:402303 | ENST00000399788 | 0 | 28 | 19_60 | 0 | 1691.0 | Domain | JmjN | |
| Tgene | KDM5A | chr5:70811993 | chr12:402303 | ENST00000399788 | 0 | 28 | 437_603 | 0 | 1691.0 | Domain | JmjC | |
| Tgene | KDM5A | chr5:70811993 | chr12:402303 | ENST00000399788 | 0 | 28 | 84_174 | 0 | 1691.0 | Domain | ARID | |
| Tgene | KDM5A | chr5:70811993 | chr12:402303 | ENST00000399788 | 0 | 28 | 419_423 | 0 | 1691.0 | Motif | GSGFP motif | |
| Tgene | KDM5A | chr5:70811993 | chr12:402303 | ENST00000399788 | 0 | 28 | 1161_1218 | 0 | 1691.0 | Zinc finger | PHD-type 2 | |
| Tgene | KDM5A | chr5:70811993 | chr12:402303 | ENST00000399788 | 0 | 28 | 1607_1661 | 0 | 1691.0 | Zinc finger | PHD-type 3 | |
| Tgene | KDM5A | chr5:70811993 | chr12:402303 | ENST00000399788 | 0 | 28 | 293_343 | 0 | 1691.0 | Zinc finger | PHD-type 1 | |
| Tgene | KDM5A | chr5:70811993 | chr12:402303 | ENST00000399788 | 0 | 28 | 676_728 | 0 | 1691.0 | Zinc finger | C5HC2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 1078_1103 | 0 | 2625.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 1223_1284 | 0 | 2625.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 144_177 | 0 | 2625.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 1078_1103 | 0 | 1360.6666666666667 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 1223_1284 | 0 | 1360.6666666666667 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 144_177 | 0 | 1360.6666666666667 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 84_119 | 0 | 2625.0 | Compositional bias | Note=Ser-rich |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 84_119 | 0 | 1360.6666666666667 | Compositional bias | Note=Ser-rich |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 295_345 | 0 | 2625.0 | Domain | Note=Myb-like |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 295_345 | 0 | 1360.6666666666667 | Domain | Note=Myb-like |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 355_470 | 0 | 2625.0 | Region | Note=Required for phosphorylation by CSNK2A1 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 823_1327 | 0 | 2625.0 | Region | Note=9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N-G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R-E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X-D-L-E-E-T |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 355_470 | 0 | 1360.6666666666667 | Region | Note=Required for phosphorylation by CSNK2A1 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 823_1327 | 0 | 1360.6666666666667 | Region | Note=9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N-G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R-E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X-D-L-E-E-T |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 1041_1094 | 0 | 2625.0 | Repeat | Note=5 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 1095_1148 | 0 | 2625.0 | Repeat | Note=6 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 1149_1203 | 0 | 2625.0 | Repeat | Note=7 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 1204_1257 | 0 | 2625.0 | Repeat | Note=8%3B approximate |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 1258_1327 | 0 | 2625.0 | Repeat | Note=9%3B approximate |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 823_877 | 0 | 2625.0 | Repeat | Note=1%3B approximate |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 878_932 | 0 | 2625.0 | Repeat | Note=2 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 933_987 | 0 | 2625.0 | Repeat | Note=3 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 988_1040 | 0 | 2625.0 | Repeat | Note=4 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 1041_1094 | 0 | 1360.6666666666667 | Repeat | Note=5 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 1095_1148 | 0 | 1360.6666666666667 | Repeat | Note=6 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 1149_1203 | 0 | 1360.6666666666667 | Repeat | Note=7 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 1204_1257 | 0 | 1360.6666666666667 | Repeat | Note=8%3B approximate |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 1258_1327 | 0 | 1360.6666666666667 | Repeat | Note=9%3B approximate |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 823_877 | 0 | 1360.6666666666667 | Repeat | Note=1%3B approximate |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 878_932 | 0 | 1360.6666666666667 | Repeat | Note=2 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 933_987 | 0 | 1360.6666666666667 | Repeat | Note=3 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 988_1040 | 0 | 1360.6666666666667 | Repeat | Note=4 |
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Fusion Gene Sequence for BDP1-KDM5A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >9568_9568_1_BDP1-KDM5A_BDP1_chr5_70811993_ENST00000358731_KDM5A_chr12_402303_ENST00000399788_length(transcript)=10930nt_BP=5017nt AGTTGCGGCGTCCTGTGAGCGCGGGGATGCTGGGAGGAGGGTGAAATTTAGCCATCGGTGTGTGGCAGGGTCATGAAAAAGCGGCGGCGG CGGGAGAGAGGAGGAGGCGGCGGCGGGGCAGTGAAACTACGGTAGCTGCCCCCTGAGCTGGTGGTGTGGCTTTGTGGGGAGGGCGTAGTT CCTAATCCCCTTTCCGGGCAGCCGCCGGGGCTCGGGGCTGTGAGCGGCCGTGAGGCTGCCTCCCCGGGCCCCCTGCCTCCGCCATGTTCC GCAGGGCACGCCTTAGCGTGAAGCCGAATGTCAGGCCTGGTGTAGGCGCCAGGGGCTCCACAGCTTCCAATCCCCAGCGTGGACGGGAGT CTCCCAGGCCGCCGGATCCTGCCACGGACTCTGCTTCCAAGCCCGCGGAGCCCACAGATGTGCCCACAGTCGATTTCGGTGGAGCGGAGC CCCAAGAAAAGGCTCCTAGGAGCAGTACTGAAAAGACTGGTGGTGACAATGATGTTGAAGAATCCAGTAGATCTTCCTCTACTGTTTCAC AGAGAAGAAAGCGAATATCAAGTACTTCTAGCCTGGTTAAGTCTAGTGTCAGTGTTCCTTCAGAATCTCATCCCTTATCTACAATTAATC AAGAGGCTCCACAGCCAACTGCCACTTCAACAAAAGAGAAACAGCCATGCTCAGACAGATACCGAATATACAAAGCCCAGAAACTGAGGG AAATGTTAAAAGAAGAATTGAGAAAAGAGAAGAAACAATGGAAAAACAAATATGCTATAAATGAAAGTCAGAGGCCACCAGATCGTTCAA AAATGACTATGAGAGACTTCATATATTATCTACCAGATAATAATCCAATGACTTCTTCACTGGAACAAGAAAAGAAAACTGAAAAGCCAT CGACTCCAGTCCAGACAAGAGAGCAAGAAGGTAAGAGTACTCCTAATGCTGAAGATAATGAAATGGAAGAAGAGACAGATGATGGGCCAT TACTGGTTCCTCGAGTAAAAGTGGCAGAAGATGGTTCCATTATTTTGGATGAAGAAAGTTTAACTGTAGAAGTTTTAAGAACAAAAGGCC CTTGTGTTGTTGAAGAAAATGACCCCATATTTGAGCGCGGTTCTACAACTACATACTCCAGCTTTAGGAAAAACTATTACTCTAAACCAT GGTCAAATAAAGAAACAGATATGTTTTTTTTAGCCATCAGCATGGTAGGAACTGACTTTTCTATGATCGGACAACTTTTTCCTCACAGAG CAAGGATAGAAATTAAGAATAAATTTAAACGGGAAGAGAAAACAAATGGATGGAGAATAGACAAAGCATTCCAGGAAAAGCGCCCTTTTG ACTTCGATTTTTTTGCTCATTTGCTTCAGAAAGTTCTTGCTGAAGAAGAGAAAAGAAAACAAAAATCTGTTAAAAATCACAGTTTAAAGG AGAAGAAATCCACCAAACCACGGAAAAATGTAAAAGTGAAAAAAGTTGCCTGTGAAGGAGTGAATAATGATCCAGATGAGTCTATGAGTT CTAGAATTTCAGACACGGAAAGATCTCAGAAGGATGCTCAGACAGTTGAAGAAGAGTCTCTGACCTTATCAAGGGAGGATGCAGAGCAGG TTGCATTAGAAGTAGACCTAAATCAAAAGAAAAGAAGGAGGAAGAAGCAAGATGGAGCTAATGAACTGGGAGTAAACAATCTTTTAGAAA ATGCCACTGTTCAGGCGGGTCCTTCTAAAGGAGAAAAACACAAGAATAAATGTCAGGCTATAAGGCCTGAGCTAAAGGAAGGTGAATGCA GTAAGGAGCAGATGCTTTCCTGCACACAAAACATAGATGGCATTGTGGGTTTTGCCTCCACTGAAAAAGTTGAGAAAAGAACTGACCCCA TCCTTTCATTAAGTAATCAACAAGATGCCACATCAGTAGCAACTGAGTCTTCAGAATCAAGCACTTCAGATTTGCCTTCATTCGAAGTTG GAATTAGAGCATTGTGTGAGGTGAATAATGCTGAGGGTAGTTGTATAGAAGAAAGAAATGTTGACCTAAAAAATAATTCACTGGAAATTG ATCAAACAGAAAATGTTAAACCAATGTTGAGAGGTCGCTTCCAAAGACCTAAACCCAATTTGTCAAGGGCTGGGAAGAAATCAGTTCTTT CACAAGGCAAAACAGAGTCAGAGAGCAAGAATTCACATTCAAAAACTTCAGTTGAAAAGAACCACGTGGAAAAAGATAAAATGAATACAT TGGACATTTTGAGAATGGAGACTACAGAGAGAGAGAATCCAGAAGCTGAAACTGTATCTGTTTTGGGTGAAAAAAATTGTCTGCAGGAAG GGAGTCAACTAAAGGCTTTAAGACCTGTACAAGTGAGGGGCCGATTGCAAAAGCCAAAGCCAAATGCAGGTAAAGCTGCTGAAAGAAAAG AAATTCTCATATCACAGGAAGAAATTGGGGCCAATGTAGAGAAGAATGAAAATGAATCCTGTGCTGATAGAGATACTCCTCAACACATGG AAGATCAATCGCGTAAAGATTTTGAAGAGGAAGATGTCATATTACAGCCTGAGAAAAATGATTCTTTTCAAAATGTGCAGCCAGATGAGC CCAAGGTTCTTAATGAATGTCTAAGCGTTCAAGAGAATAATAAGGCAAATAAACTTAACCAAGTCCCAATTCTAAGGACTCGATTTCAGA AACCAAAGCCAAATATAGGAAGAGGAACTGGAAGGAGAGAAATTTCCTCAAAGGAAGAGGTACTAGAGAAGATTCTTGTCTCTGGGGAAA TGGCGGCAGCATTGAGAGAAACTGTAAGACTAGACACCTCACCAAAGGAGATGGTACCAGCAGAGATTAATACTAAAGAAATGCAGTCAG ATTTAAAAGAAACTGGAAGAAGAGCCATTTCTCCCAGGGAGAAGATTCTAGATGTGATTGATGACACCATAGAAATGGAGACAGGTCTGA AAGCAATGGGAAGAGAGATTTGTCTAAGGGAGAAGACGCCAGAGGTGATTGATGCCACTGAGGAAATAGACAAAGATTTGGAAGAAGCTG GAAGAAGAGAAATATCCCCACAGAAAAATGGCCCAGAGGAGGTTAAGCCTCTAGGTGAAGTGGAGACAGATTTGAAAGCAACTGGAAATG AGAGTTCCCCAAGGGAGAAGACACCAGAGGTGACTGATGCCACTGAGGAAATAGACAAAAATTTGGAAGAAACTGGAAGAAGAAAAATAT CCCCAAGGGAAAATGGCCCAGAGGAGGTCAAGCCTGTAGATGAAATGGAGACAGATTTGAACGCAACTGGAAGAGAGAGTTCTCCAAGGG AGAAGACACCAGAGGTGATTGATGCTACTGAGGAAATAGATTTGGAAGAAACTGAAAGAGAAGTATCCCCACAGGAAAATGGACTAGAGG AGGTCAAGCCTCTAGGTGAAATGGAGACGGATTTGAAAGCAACTGGAAGAGACAGTTTCCCAAGGGGGAAGACACCAGAGGTGATTGATG CCATTGAGGAAATAGAGATAGATTTGGAAGAAACTGAAAGAGAAATATCCCCACAGGAAAATGGCCTAGAGGAGGTTAAGCCTCTAGGTG AAATGCAAACAGATTTGAAAGCAACCGGAAGGGAGATTTCCCCAAGGGAGAAGACACCAGAGGTGATTGATGCCACTGAGGAAATAGACA AAGATCTGGAAGAAACTGGAAGAAGAGAAATATCCCCAGAGGAAAATGGCCCAGAGGAGGTCAAGCCTGTAGATGAAATGGAGACAGACT TGAAAACAACTGGAAGAGAGGGTTCCTCAAGGGAGAAGACACGAGAGGTGATTGATGCTGCTGAGGTAATAGAGACAGATTTGGAAGAAA CTGAAAGAGAAATATCGCCACAGGAAAATGGCCCAGAGGAGGTCAAGCCTGTAGGTAAAATGGAGACAGATTTGAAAGAAATTAGAGAAG AAATTTCCCAAAGGGAAAAGGTGCTAGCAGAGTTCAGTGCTATAAGGGAAAAGGAGATTGATTTGAAAGAAACTGGAAAAAGAGACATTC CCATCATGGAGAAAGTATCAGGAAAGATGGCTGTTGTTGAAGAAATGGAGGCAGATTTGAAAGAAACTGGAAAAGAAAATTTTAGAGAGA GAGGATCTGAAGAGATCTGTGTTACTGAGGAAAAGGTGGCAGAATTGAAACAAACTGGAAAAACAGACATTTCTCCAAGGGAAAACGAGC TAGAGGAGACCAGTACCTCAAGACAAACTGACACACATTTAATGCAGAGCGGTAGCAATGACTTCAGTGCTGTGCCTTCACTAGATATTC AGAACATTAGCAGTGAAGTACTGTCGATGATGCATACACCTGTAGAAGAAAAAAGAAATTCTGAAAAAGAAGTATCAAGTCACTTCAGTC ATTTCAAGATTTCTTCACAGACTCATGAATCTGATAAAACAGAAGTCCAGGGGATTCAATCTCCAGATGTTCCAGAGCAGTTTTCAGATA TTAATTTAAGCAAATCTCTTCCTCAAGAACAGAAGCCACTTGAAATTAAACCAGCACCTTTTGTGAGGAGCCGATTCAAAAGACCAAAAC CAAACTTAGCAAGAGCAGCTTTGAAGAGAGAGACTACAGAATCAGAAAAATATATATATGAGAAGAAATCAGAAACCAAGAAAATGGAGA CTATTGTGATGCAAGAAAATAATGAACAAACTGATACTCTCCCTTCTCAACATGATGAAGCTTCCCTAATGATATCAAGAGAAAAAGACA CATTAGGTCACAGGAATGAGGAGGCTGTGATATTGCCATGTACACAGACTGAAAGGAACCTTTCACCTTCAAATTCTTGTGAACCTAAAG AGGAGTCTCAGTCAGCACCAGTCCAGAAAAATGACTCAGTTGTTTCTGTGGGACAGGACAGAGGCAAATAGTAGACAAAGGTGAAGCCAA AGGCATAATTAAGGAAGGAAGAACGATATTACCAAAAGATGAAACTGAAAAGAAAGTCTTAACTGTGGTAGACTGGGTACAATGTGATGG TGGCTGTGATGAGTGGTTTCATCAAGTTTGTGTGGGTGTATCTCCAGAAATGGCTGAAAATGAAGATTACATCTGTATAAACTGTGCAAA GAAGCAGGGGCCAGTTAGCCCAGGTCCAGCACCACCTCCTTCCTTCATAATGAGCTACAAACTACCAATGGAGGATCTTAAAGAGACCAG TTAGCAGATGCTTGGTTAGTTTGGGACATGGGGGGACATGGACCACATTGAGACCTTAGTCATCAAGTAGAGTGGTTTATATCCACTTGG AATGTTGCTTCCAAAGATGAATGGCCTTCAGAGAAAGTCCCCTTAGTGCTGGCTTCCTCTTTGCATGGACTCTGTGGGTTACATTCTCTA TCAACATATCTATGCAGAGGGTGTCTTCTTTGGTACAACAGCCAATATTTCATGTCTCCTTTGAGTGTGGTTTACTGCATTAAGGCCAGA TGCTTAATTGAGCTCTAGGGTGGCTGGTTAGTATTAATACATTGGTGTGCTAACAGGGCATATAGGATGTGGCTTTTGTCCAGCTGATAG TAGTTAGAGGCTTACAACTTAGGAGCAGCACCAACTGAAGGTGCTAATTGCTTGGATCTCCTTCATTGGGATAGTTGGAGAGGGATTGGA GTACCACTTTCCTTCCACTGTTACCTGGTACTTAATGCCCTAAAGATACAACTAGGAGTAACAGGGCCAAAGTTATTTCTGTTAGACGTC AAGGAATGGTATCACAGTCTATTGACCTCAGCGATTTGTGCTTGTTTGTGCTAGAAGAACATCCCAAATAGGAGAACCTCTCACAAGCTG GGGCAGGTCACCTTATCTTTGTAAGATGAGGATATCATCTAGATCAGAAATCTGACTAGATTGGATTCTGAGGAGAAGAACCTACTACAA GGCAAGGAGCCGTTTTTTGGCTTTGAAAAGTCTTGCTGTCTTGGGTCTACATTTTAGGGAAGAGCAGGTACATGGATCCAGGCTTCTGCC AAAAAAAAAAAGAGAAGAAGATGACGATGATGACCAGTCGTACTATCTTACTGAGCCACAGTGATGCATGCTTTTCGGGGAAAACTTCAT TCACAAGTATTCCAGACACCAGGCTTCAGGCATGGCCATGAGCAAGACCAGCAAATAACAGCTTTTTGCCTTGCAGCCCTGACCCCAATG TCTGCTGTTTCCAACACTGGTGATTTCTAACTACGGCCCACAGCAGATGCTGTTGAATAACACCATGGCTTCATCAGAGGATGTGGGGTT GTAGTACCTCTGGGTGATGAAGTTGTTTTAGTAAATCCATTTTTAAAAAAAAAAAAGGACTTGTTTTTACTTTTTTCTAAATGTCTCTGA CTACTGACTGTTCTATACATAGATTATTTTTCCTTTTTTAATATACATATATGAATATATAAATATATATATTTACTGTTACCAGCAGCA TATGACAGAGTTTCAACATCAAAAATCCATTTGGGGGCTTGCTTTTTCTTTTTTGCTTTAAAAAAAAAAATCCCATTCCTTCTTTGTAGT ACAAGGAGTTAGCACTCCCTCCTCCATCCCAGCCTGACCAGATCTTCCATTTTGCTTTTGTTCATATAGATAATTATATGTCCTTTGTGT GTTGGGACTTGTCCCTGTCTGTTGGGAAACTTGGTCTCACTCTAGTCTGTGCTGGCTCTTTTTTCTTTTGTGTGTGAATGTTTGAAACTA TGGTGCTGTGTCCTCTTCCCTCCTGTTGTGTTCTCTGTTCTTCTTAAGGTATTAGGTAAGCTGTATGTAAACTCTTATTAGAAGGGGACT AATTTTTTTTTAAAGGACAAAAAAAAAAATGACTAAAAATAGTGTTTTGTCATCACTGTCTGGTGTCTTTATTTTGGTTTAAAAAAATCT GTGGTTTGACTTAAATTCATCAGTTTTCCTTTTAAAGGGGGGATTGGGGTGGACCTAGCAACAGCTTATAGTTTCCTCTTCCCTTTTTGC CCCAGTCTCTTTTAAAGAACTGTCTTCTAGTAACTAGAAGTGAAATGTACTGTCCAGTTACAGTTTGAGTGGGTATGAGATTTAACTCAA AAGGAATCTTACAAAAAAAAAGATGTTTTCTTATAAAATCCAATTTCTGTAAATGTTTTCTCTGAAGTTCATACTACCTACTTTTTATTC ATTCTTAATACTGTATAACATTTTGAGTGTTTTGACTTGTTCAGAGGTTTGTTAGTGTTGCTGTGCATATGTCTTGAGGTCTCATCTGAA GTAAGTTTGTGTATGATCGAAGATTTCAATGGATATTGCAAGGTAACTAATTAACTGATTTCATAAGTTTTCGTTTTGCCAAGCTAACGA TTATCAATTAAGAATTTCCTCTGGTTGATGTTATACAAGAAAGCACAATATTTTTTGCCTGTTGATCTTCTTTGTAACAGTCTTCAGATA TTTGTGGGTTAAAAATTGAATGTAATTTTAAGTGACAGATGCCTGGAATACATTTAAAATTTTTATTTTTCCTTCCTAATCATCCATTAA CTATTCCACTATCAGTGGAGAGTCATGAGGATGCTGAGAAAGTATGAATAGCTTCCTGTCACCTTCTGACGTTTTGAAACTTAAATATGT CTTTTCGTTGATACTGTGGGATTTTCTGTATTTACTTGACAGTCATGGAGGATTTGGTATGACTTGACCACAGGTTTAGACCAAGGCTGA GAAGAACAGAAGGGAGAAATTAATGGCAAAACAAAAAATACACAAATCTGCGGTTTTGGAATTAATGAAACAAGATTCATCTATTTAAAG AAATGTTGGTGTTCTAATACAAAGCATTATTTTCACTTAGAGAAAATTACTTACTTGCTCCCTTCTGTATTGTAATATTTTGTATTAAGA CATGATTTAAAATGTCTTTCTACCCTTATCTCCTCTAAACTGCAACTGAAGTTGCAATTCTTCATCATTAGTATTTTAACTCTGGCAAAG GTTATAGAAAGAAAAATGGAAATATGGTAGGCCTGTGGTATTCTTAAAAGCTAAGTCATTAGAACTATGCAGATCCCCAAGTTTAAAAGT ACAAATACAGCACCAGTAGTTAGCTTTCTAGCTGGGGGAGAAGACAGGAGATTTTTCTTCCACAGATGTTTATTTTGCTTCCTGATAGGT ACTGCAGCAAAGCCATGTTGATGTGTAGATGCATGACTTCCTCACTAAGCTGCTGCACACCAGCTTTGCCTGCATGATTCAAATTTGTGC CTCAGTAAAATTATAAATTATTGCATGTCATACCTTGAATAATGGAAACGGCAAACATTAAACCTGTGATTACCCATAATGTACTTTAAT AATAAAAAACATGGCAGCCAGGTGCAGTAGAGTGCACCTGTGGTCAGGAGGCTGAAGTGGGAAGATTGCTTCAACCTGTGAGTTTGAGTC CCGCCTGGTCAACAGCGAGACCCCATGTGTCTGTCTGTCTCTCTCTTTTTTTAAAGGACAGAGGCTAAGCTGTAAGGTTAGCATGGTTCT GCCTGGGCTTTGCTTCTGTGCTTCTGTGCAGGCTGAGCTGTAAGGTTAGCATGGTTCTGCCTGGGCTTTGCTTCTGCGCTTCTGTGCAGG CTGAGCTGTAAGGTTAGCATGGTTCTGCCTGGGCTTTGCTTCTGCGCTTCTGTGCAGGCTGAGCTGTAAGGTTAGCATGGTTCTGCCTGG GCTTTGCTTCTGCGCTTCTGTGCTAGCAGGTGCCCACAAAATGTCTTTTTGAATTTCTTAATTTTTGGGTTCTGGATGCAATTCGTGCAC GCCAAGAAACTACTTGCTTGTCAGTATTTTAATTCTGTAGTACATGTGTGTGAATATCAGCCAGTACTTACAGTAGGAGGATGAACAGAA AAACTGAGAAGACCTGTCTTTCAAAAGATGGGTTTATCCACTTTTTAAGGGAAAAAGTGACAGTTTGGCATGGGATTTGAAAAGTGGAAA TTGTGGAAAAATTGAGCTGTTGAAGTCCCACATATAACCAGATTTAATAAAGCTTCACATGTGAATTAGCTCCATATGTGTGTAGAAGGT TGCTTTTATAGCAGGTCCTTAAGTACTCCTTTTGAAATTCCTCCTTTTTTTTTAAGTCATACCATTACTTCTTTGGATATGAATGTCCCA AGTGGTATCTCCTACTGTAGTATGAGGAAGAATGGCTGTTAATGTATTTTTTGAATTTTGGTCTTGTCTTGGCCTGGATCATATCCAGTC ACCACTATGCAACAAATGATGTGCACTGGGCAAGGATATGATGGGTTATGAAAGCTGTATCTTGTTTGTTTTTTCTTTTGCAGTACTCCA AGTGGTCTAAACAGGAATGTCTTGTAAAACCTCAAGACTCCCTATTGATTATTCCCTTACATATTTATTTACAATTTATCAGGGTAATTG GTGGTGCCTTATGAAAAGTATAACTCGATTTCTTGATCTTTGAGCATGTTTTGTGTTTCTTGTGTTTTCTAAAAGAATATTAGATATGGT TAATTGCATTACATCTAAAAGATTTAAAAAATTGTGTGTATGCTCAGGTTCCCCACACCCATACCCACCCTAACCCCTGTCATTTACATT GGTGGCAACTTTAAATGGTAACCAAGCAAAAGTACATTTTGATAATGAGTATTGATAATCCTGAGGAAAACTAGTGAGTATATGGGAGCC ACCTTTGACCTGTGCCAAAGCAGTTTCTAATTTCATTTGCTAACTATAAAATAAAGAACTGAGCCAAAATAATTTGATCAGTGGTGTGAT TAGCCTATTATCATTGCTGAGAATAGTGTTTTTGGAGTGTGAAGTGATTCCTGAAGATTTCACCTGCCTTCTGTTTCCAGCAAGAATCCA GTGATGACCAACACATTTCCTCACTTTTGGTTCTTGAGAAGTTTATCCCTTTGCAACAAACCATTAATAGGGAAAACAAGGAAATGCTTT CCCTTTCTCTTTGGCTTCTTAAAGCTCACAACCAATTCAGACCCCAAGTTACTTCAGAGAAGCAAATGGCACCTTTTCCCCATTGCCAAG GATCCCAGCTTATGCAGATATGAAGGACGGATCATTTCTGAAAATGTTAAGACTCTGCTTGCAGTGGACTTGGCCTCAGTTTCATGAAAT GTGTAACTCTGTATGTGTATGTTAGGAGGAGGGTTGGTTGAAAGAGCGGGGGCAGGGAGGGGAATCTGATTACCTCTTGGGAAATAATTT TCTTGCCAACAAAAAGATACACTTGAAGTTTCTTAAGGTGGCAAGTCCATTAAAAAAAAAAATTGTGTTGGACCCTCCCAGTTTAGATCA AGTATTTCTTGGGGGTCTTGCTATTGTGGTTGATACCAATAAATGGAAGATCCAGAATATTTTCATTTAAAGCTCAACCATTAATTGGAA CATGGTGAAACATTGTACACATTGTAAAAGTAGGGAACAGTACAAAAGAATGGAATCAAATACTATATTATGTGAATAAACTAGAGTGAT TTTGGAATTTCACTCTCTTCAGAAAGGAAAGGACTCTTCAGAGAAGAAACGGAAACGGAAGCTAGAAAAGGTAGAGCAACTTTTTGGAGA AGGAAAACAGAAGTCCAAGGAGTTAAAGAAAATGGACAAACCTAGAAAGAAGAAATTAAAATTAGGTGCAGACAAATCAAAGGAGCTGAA TAAACTGGCCAAGAAACTAGCAAAAGAAGAAGAGAGAAAGAAAAAGAAGGAGAAGGCTGCTGCAGCCAAAGTTGAACTTGTGAAAGAGAG CACTGAAAAGAAAAGAGAGAAAAAGGTGCTGGACATCCCCTCAAAGTATGACTGGTCAGGAGCAGAGGAGTCTGATGATGAGAATGCTGT GTGCGCAGCACAGAACTGCCAAAGGCCCTGCAAGGACAAG >9568_9568_1_BDP1-KDM5A_BDP1_chr5_70811993_ENST00000358731_KDM5A_chr12_402303_ENST00000399788_length(amino acids)=1555AA_BP= MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSST VSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPD RSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRT KGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKR PFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDA EQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRT DPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKS VLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAE RKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTR FQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMET GLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRR KISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEV IDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEME TDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKR DIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSL DIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKR PKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCE PKEESQSAPVQKNDSVVSVGQDRGK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for BDP1-KDM5A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000358731 | + | 1 | 39 | 1_299 | 0 | 2625.0 | ZBTB43 |
| Hgene | BDP1 | chr5:70811993 | chr12:402303 | ENST00000380675 | + | 1 | 38 | 1_299 | 0 | 1360.6666666666667 | ZBTB43 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for BDP1-KDM5A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for BDP1-KDM5A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BDP1 | C3711374 | Nonsyndromic Deafness | 1 | CLINGEN |
| Tgene | C0020796 | Profound Mental Retardation | 1 | CTD_human | |
| Tgene | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human | |
| Tgene | C0917816 | Mental deficiency | 1 | CTD_human | |
| Tgene | C3714756 | Intellectual Disability | 1 | CTD_human |
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