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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP15-KYNU (FusionGDB2 ID:HG55843TG8942)

Fusion Gene Summary for ARHGAP15-KYNU

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP15-KYNU
Fusion gene ID: hg55843tg8942
HgeneTgene
Gene symbol

ARHGAP15

KYNU

Gene ID

55843

8942

Gene nameRho GTPase activating protein 15kynureninase
SynonymsBM046KYNUU|VCRL2
Cytomap('ARHGAP15')('KYNU')

2q22.2-q22.3

2q22.2

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 15rho-type GTPase-activating protein 15kynureninaseL-kynurenine hydrolase
Modification date2020031320200313
UniProtAcc.

Q16719

Ensembl transtripts involved in fusion geneENST00000295095, ENST00000409869, 
ENST00000473426, 
ENST00000295095, 
ENST00000409869, ENST00000473426, 
Fusion gene scores* DoF score15 X 13 X 5=9757 X 7 X 6=294
# samples 1610
** MAII scorelog2(16/975*10)=-2.60733031374961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/294*10)=-1.55581615506164
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP15 [Title/Abstract] AND KYNU [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP15(144008169)-KYNU(143742653), # samples:2
ARHGAP15(143887035)-KYNU(143642918), # samples:2
Anticipated loss of major functional domain due to fusion event.ARHGAP15-KYNU seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP15-KYNU seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGAP15

GO:0008360

regulation of cell shape

12650940

TgeneKYNU

GO:0019805

quinolinate biosynthetic process

9291104

TgeneKYNU

GO:0034341

response to interferon-gamma

9291104

TgeneKYNU

GO:0043420

anthranilate metabolic process

11985583


check buttonFusion gene breakpoints across ARHGAP15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across KYNU (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-38-4630-01AARHGAP15chr2

144008169

-KYNUchr2

143742653

+
ChimerDB4LUADTCGA-38-4630-01AARHGAP15chr2

144008169

+KYNUchr2

143742653

+
ChimerDB4LUSCTCGA-NC-A5HJ-01AARHGAP15chr2

143887035

-KYNUchr2

143642918

+
ChimerDB4LUSCTCGA-NC-A5HJARHGAP15chr2

143887035

+KYNUchr2

143642918

+


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Fusion Gene ORF analysis for ARHGAP15-KYNU

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000295095ENST00000410015ARHGAP15chr2

144008169

+KYNUchr2

143742653

+
5UTR-5UTRENST00000295095ENST00000264170ARHGAP15chr2

143887035

+KYNUchr2

143642918

+
5UTR-5UTRENST00000295095ENST00000375773ARHGAP15chr2

143887035

+KYNUchr2

143642918

+
5UTR-5UTRENST00000295095ENST00000409512ARHGAP15chr2

143887035

+KYNUchr2

143642918

+
5UTR-5UTRENST00000295095ENST00000410015ARHGAP15chr2

143887035

+KYNUchr2

143642918

+
In-frameENST00000295095ENST00000264170ARHGAP15chr2

144008169

+KYNUchr2

143742653

+
In-frameENST00000295095ENST00000375773ARHGAP15chr2

144008169

+KYNUchr2

143742653

+
In-frameENST00000295095ENST00000409512ARHGAP15chr2

144008169

+KYNUchr2

143742653

+
intron-3CDSENST00000409869ENST00000264170ARHGAP15chr2

144008169

+KYNUchr2

143742653

+
intron-3CDSENST00000409869ENST00000375773ARHGAP15chr2

144008169

+KYNUchr2

143742653

+
intron-3CDSENST00000409869ENST00000409512ARHGAP15chr2

144008169

+KYNUchr2

143742653

+
intron-3CDSENST00000473426ENST00000264170ARHGAP15chr2

144008169

+KYNUchr2

143742653

+
intron-3CDSENST00000473426ENST00000375773ARHGAP15chr2

144008169

+KYNUchr2

143742653

+
intron-3CDSENST00000473426ENST00000409512ARHGAP15chr2

144008169

+KYNUchr2

143742653

+
intron-5UTRENST00000409869ENST00000264170ARHGAP15chr2

143887035

+KYNUchr2

143642918

+
intron-5UTRENST00000409869ENST00000375773ARHGAP15chr2

143887035

+KYNUchr2

143642918

+
intron-5UTRENST00000409869ENST00000409512ARHGAP15chr2

143887035

+KYNUchr2

143642918

+
intron-5UTRENST00000409869ENST00000410015ARHGAP15chr2

143887035

+KYNUchr2

143642918

+
intron-5UTRENST00000473426ENST00000264170ARHGAP15chr2

143887035

+KYNUchr2

143642918

+
intron-5UTRENST00000473426ENST00000375773ARHGAP15chr2

143887035

+KYNUchr2

143642918

+
intron-5UTRENST00000473426ENST00000409512ARHGAP15chr2

143887035

+KYNUchr2

143642918

+
intron-5UTRENST00000473426ENST00000410015ARHGAP15chr2

143887035

+KYNUchr2

143642918

+
intron-intronENST00000409869ENST00000410015ARHGAP15chr2

144008169

+KYNUchr2

143742653

+
intron-intronENST00000473426ENST00000410015ARHGAP15chr2

144008169

+KYNUchr2

143742653

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000295095ARHGAP15chr2144008169+ENST00000264170KYNUchr2143742653+14596411671309380
ENST00000295095ARHGAP15chr2144008169+ENST00000375773KYNUchr2143742653+1070641167835222
ENST00000295095ARHGAP15chr2144008169+ENST00000409512KYNUchr2143742653+13106411671309381

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000295095ENST00000264170ARHGAP15chr2144008169+KYNUchr2143742653+0.0007252620.9992748
ENST00000295095ENST00000375773ARHGAP15chr2144008169+KYNUchr2143742653+0.0033335480.9966665
ENST00000295095ENST00000409512ARHGAP15chr2144008169+KYNUchr2143742653+0.0007928510.9992072

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Fusion Genomic Features for ARHGAP15-KYNU


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGAP15chr2144008169+KYNUchr2143742652+0.0008815290.9991185
ARHGAP15chr2143887035+KYNUchr2143642917+1.04E-060.9999989
ARHGAP15chr2144008169+KYNUchr2143742652+0.0008815290.9991185
ARHGAP15chr2143887035+KYNUchr2143642917+1.04E-060.9999989

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGAP15-KYNU


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:144008169/chr2:143742653)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KYNU

Q16719

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. {ECO:0000269|PubMed:11985583, ECO:0000269|PubMed:17300176, ECO:0000269|PubMed:28792876, ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP15chr2:144008169chr2:143742653ENST00000295095+614281_470158476.0DomainRho-GAP
HgeneARHGAP15chr2:144008169chr2:143742653ENST00000295095+61479_189158476.0DomainPH
TgeneKYNUchr2:144008169chr2:143742653ENST00000264170714165_168243466.0RegionNote=Pyridoxal phosphate binding
TgeneKYNUchr2:144008169chr2:143742653ENST00000375773712165_168243346.6666666666667RegionNote=Pyridoxal phosphate binding
TgeneKYNUchr2:144008169chr2:143742653ENST00000409512815165_168243466.0RegionNote=Pyridoxal phosphate binding


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Fusion Gene Sequence for ARHGAP15-KYNU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5946_5946_1_ARHGAP15-KYNU_ARHGAP15_chr2_144008169_ENST00000295095_KYNU_chr2_143742653_ENST00000264170_length(transcript)=1459nt_BP=641nt
GCCTTTTTCTTCCCCCAGTACTGAAATTAAGCAGCATCCAACACAGGCCTACTCTTACGACATGTGACTTTACTGTTTTCCGTTTTTGTT
GAAAGAGTCATTAACAGTTAGGAGTTGATGGCAGTTTCAATAACAGGTCATTGCCGAGAAAAGGATAGCACTATAATATGCAGAAATCTA
CAAATTCTGATACTTCCGTGGAAACACTGAATTCTACCCGCCAAGGCACAGGAGCTGTGCAAATGAGAATCAAAAATGCCAACAGCCACC
ATGACAGGCTCAGCCAAAGTAAATCCATGATCCTCACCGATGTCGGGAAGGTCACTGAACCTATATCCAGACACAGAAGGAATCATTCAC
AGCATATCTTGAAAGATGTCATTCCTCCATTGGAACAACTGATGGTTGAAAAAGAAGGTTATCTGCAAAAAGCTAAAATTGCAGATGGAG
GAAAGAAACTAAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCTAGTCGAAGAATTGAATTTTACAAAGAATCCAAGCAACAGGCTC
TGTCCAATATGAAAACTGGGCACAAACCAGAAAGTGTGGATTTGTGTGGAGCACACATTGAATGGGCCAAGGAAAAATCGAGCAGAAAGA
ATGTCTTTCAGGGTTGTTATGTTGGCTTTGATCTAGCACATGCAGTTGGAAATGTTGAACTCTACTTACATGACTGGGGAGTTGATTTTG
CCTGCTGGTGTTCCTACAAGTATTTAAATGCAGGAGCAGGAGGAATTGCTGGTGCCTTCATTCATGAAAAGCATGCCCATACGATTAAAC
CTGCATTAGTGGGATGGTTTGGCCATGAACTCAGCACCAGATTTAAGATGGATAACAAACTGCAGTTAATCCCTGGGGTCTGTGGATTCC
GAATTTCAAATCCTCCCATTTTGTTGGTCTGTTCCTTGCATGCTAGTTTAGAGATCTTTAAGCAAGCGACAATGAAGGCATTGCGGAAAA
AATCTGTTTTGCTAACTGGCTATCTGGAATACCTGATCAAGCATAACTATGGCAAAGATAAAGCAGCAACCAAGAAACCAGTTGTGAACA
TAATTACTCCGTCTCATGTAGAGGAGCGGGGGTGCCAGCTAACAATAACATTTTCTGTTCCAAACAAAGATGTTTTCCAAGAACTAGAAA
AAAGAGGAGTGGTTTGTGACAAGCGGAATCCAAATGGCATTCGAGTGGCTCCAGTTCCTCTCTATAATTCTTTCCATGATGTTTATAAAT
TTACCAATCTGCTCACTTCTATACTTGACTCTGCAGAAACAAAAAATTAGCAGTGTTTTCTAGAACAACTTAAGCAAATTATACTGAAAG
CTGCTGTGGTTATTTCAGTATTATTCGATTTTTAATTATTGAAAGTATGTCACCATTGACCACATGTAACTAACAATAAATAATATACCT

>5946_5946_1_ARHGAP15-KYNU_ARHGAP15_chr2_144008169_ENST00000295095_KYNU_chr2_143742653_ENST00000264170_length(amino acids)=380AA_BP=158
MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQKAK
IADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQGCYVGFDLAHAVGNVELYLHDW
GVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMK
ALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFH

--------------------------------------------------------------
>5946_5946_2_ARHGAP15-KYNU_ARHGAP15_chr2_144008169_ENST00000295095_KYNU_chr2_143742653_ENST00000375773_length(transcript)=1070nt_BP=641nt
GCCTTTTTCTTCCCCCAGTACTGAAATTAAGCAGCATCCAACACAGGCCTACTCTTACGACATGTGACTTTACTGTTTTCCGTTTTTGTT
GAAAGAGTCATTAACAGTTAGGAGTTGATGGCAGTTTCAATAACAGGTCATTGCCGAGAAAAGGATAGCACTATAATATGCAGAAATCTA
CAAATTCTGATACTTCCGTGGAAACACTGAATTCTACCCGCCAAGGCACAGGAGCTGTGCAAATGAGAATCAAAAATGCCAACAGCCACC
ATGACAGGCTCAGCCAAAGTAAATCCATGATCCTCACCGATGTCGGGAAGGTCACTGAACCTATATCCAGACACAGAAGGAATCATTCAC
AGCATATCTTGAAAGATGTCATTCCTCCATTGGAACAACTGATGGTTGAAAAAGAAGGTTATCTGCAAAAAGCTAAAATTGCAGATGGAG
GAAAGAAACTAAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCTAGTCGAAGAATTGAATTTTACAAAGAATCCAAGCAACAGGCTC
TGTCCAATATGAAAACTGGGCACAAACCAGAAAGTGTGGATTTGTGTGGAGCACACATTGAATGGGCCAAGGAAAAATCGAGCAGAAAGA
ATGTCTTTCAGGGTTGTTATGTTGGCTTTGATCTAGCACATGCAGTTGGAAATGTTGAACTCTACTTACATGACTGGGGAGTTGATTTTG
CCTGCTGGTGTTCCTACAAGTATTTAAATGCAGGAGCAGGAGGAATTGCTGGTGCCTTCATTCATGAAAAGCATGCCCATACGATTAAAC
CTGCGAGATCGGAGTTCTTTAATTAGGAATGGAATGCAACAGATTTGGACAAGTCAAGGACAAGAGCTTTAGAGAGACCAAAGAGTTTTT
CACTGTTAAAGTGTCCAGTATGTAGCCGAGAACCATATGGAGAACATCAAATACAGTGGAACAAATGTAACTGCTATTGATGTCACACTT

>5946_5946_2_ARHGAP15-KYNU_ARHGAP15_chr2_144008169_ENST00000295095_KYNU_chr2_143742653_ENST00000375773_length(amino acids)=222AA_BP=158
MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQKAK
IADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQGCYVGFDLAHAVGNVELYLHDW

--------------------------------------------------------------
>5946_5946_3_ARHGAP15-KYNU_ARHGAP15_chr2_144008169_ENST00000295095_KYNU_chr2_143742653_ENST00000409512_length(transcript)=1310nt_BP=641nt
GCCTTTTTCTTCCCCCAGTACTGAAATTAAGCAGCATCCAACACAGGCCTACTCTTACGACATGTGACTTTACTGTTTTCCGTTTTTGTT
GAAAGAGTCATTAACAGTTAGGAGTTGATGGCAGTTTCAATAACAGGTCATTGCCGAGAAAAGGATAGCACTATAATATGCAGAAATCTA
CAAATTCTGATACTTCCGTGGAAACACTGAATTCTACCCGCCAAGGCACAGGAGCTGTGCAAATGAGAATCAAAAATGCCAACAGCCACC
ATGACAGGCTCAGCCAAAGTAAATCCATGATCCTCACCGATGTCGGGAAGGTCACTGAACCTATATCCAGACACAGAAGGAATCATTCAC
AGCATATCTTGAAAGATGTCATTCCTCCATTGGAACAACTGATGGTTGAAAAAGAAGGTTATCTGCAAAAAGCTAAAATTGCAGATGGAG
GAAAGAAACTAAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCTAGTCGAAGAATTGAATTTTACAAAGAATCCAAGCAACAGGCTC
TGTCCAATATGAAAACTGGGCACAAACCAGAAAGTGTGGATTTGTGTGGAGCACACATTGAATGGGCCAAGGAAAAATCGAGCAGAAAGA
ATGTCTTTCAGGGTTGTTATGTTGGCTTTGATCTAGCACATGCAGTTGGAAATGTTGAACTCTACTTACATGACTGGGGAGTTGATTTTG
CCTGCTGGTGTTCCTACAAGTATTTAAATGCAGGAGCAGGAGGAATTGCTGGTGCCTTCATTCATGAAAAGCATGCCCATACGATTAAAC
CTGCATTAGTGGGATGGTTTGGCCATGAACTCAGCACCAGATTTAAGATGGATAACAAACTGCAGTTAATCCCTGGGGTCTGTGGATTCC
GAATTTCAAATCCTCCCATTTTGTTGGTCTGTTCCTTGCATGCTAGTTTAGAGATCTTTAAGCAAGCGACAATGAAGGCATTGCGGAAAA
AATCTGTTTTGCTAACTGGCTATCTGGAATACCTGATCAAGCATAACTATGGCAAAGATAAAGCAGCAACCAAGAAACCAGTTGTGAACA
TAATTACTCCGTCTCATGTAGAGGAGCGGGGGTGCCAGCTAACAATAACATTTTCTGTTCCAAACAAAGATGTTTTCCAAGAACTAGAAA
AAAGAGGAGTGGTTTGTGACAAGCGGAATCCAAATGGCATTCGAGTGGCTCCAGTTCCTCTCTATAATTCTTTCCATGATGTTTATAAAT

>5946_5946_3_ARHGAP15-KYNU_ARHGAP15_chr2_144008169_ENST00000295095_KYNU_chr2_143742653_ENST00000409512_length(amino acids)=381AA_BP=158
MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQKAK
IADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQGCYVGFDLAHAVGNVELYLHDW
GVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMK
ALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGAP15-KYNU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP15-KYNU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneKYNUQ16719DB00114Pyridoxal phosphateCofactorSmall moleculeApproved|Investigational|Nutraceutical

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Related Diseases for ARHGAP15-KYNU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGAP15C4317009Diverticular Diseases2CTD_human
HgeneARHGAP15C4505353Diverticular Bleeding2CTD_human
TgeneC0268474Hydroxykynureninuria2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0000772Multiple congenital anomalies1GENOMICS_ENGLAND
TgeneC0021368Inflammation1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0270715Degenerative Diseases, Central Nervous System1CTD_human
TgeneC0524851Neurodegenerative Disorders1CTD_human
TgeneC0751733Degenerative Diseases, Spinal Cord1CTD_human
TgeneC1302790Congenital malformation syndrome1GENOMICS_ENGLAND
TgeneC4540004VERTEBRAL, CARDIAC, RENAL, AND LIMB DEFECTS SYNDROME 11ORPHANET
TgeneC4540014VERTEBRAL, CARDIAC, RENAL, AND LIMB DEFECTS SYNDROME 21GENOMICS_ENGLAND;ORPHANET