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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAPK1-ARHGEF7 (FusionGDB2 ID:HG5594TG8874)

Fusion Gene Summary for MAPK1-ARHGEF7

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPK1-ARHGEF7
Fusion gene ID: hg5594tg8874
HgeneTgene
Gene symbol

MAPK1

ARHGEF7

Gene ID

5594

8874

Gene namemitogen-activated protein kinase 1Rho guanine nucleotide exchange factor 7
SynonymsERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPKBETA-PIX|COOL-1|COOL1|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXB
Cytomap('MAPK1')('ARHGEF7')

22q11.22

13q34

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2rho guanine nucleotide exchange factor 7PAK-interacting exchange factor betaRho guanine nucleotide exchange factor (GEF) 7SH3 domain-containing proline-rich protein
Modification date2020032720200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000215832, ENST00000398822, 
ENST00000544786, ENST00000491588, 
Fusion gene scores* DoF score20 X 16 X 10=320013 X 13 X 5=845
# samples 2413
** MAII scorelog2(24/3200*10)=-3.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/845*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAPK1 [Title/Abstract] AND ARHGEF7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAPK1(22221612)-ARHGEF7(111870026), # samples:2
Anticipated loss of major functional domain due to fusion event.MAPK1-ARHGEF7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAPK1-ARHGEF7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAPK1-ARHGEF7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MAPK1-ARHGEF7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAPK1

GO:0006468

protein phosphorylation

23184662

HgeneMAPK1

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

16314496

HgeneMAPK1

GO:0018105

peptidyl-serine phosphorylation

15850461

HgeneMAPK1

GO:0034198

cellular response to amino acid starvation

11096076

HgeneMAPK1

GO:0038127

ERBB signaling pathway

15133037

HgeneMAPK1

GO:0051403

stress-activated MAPK cascade

11096076

HgeneMAPK1

GO:0070371

ERK1 and ERK2 cascade

16314496

HgeneMAPK1

GO:0070849

response to epidermal growth factor

18794356

TgeneARHGEF7

GO:0043547

positive regulation of GTPase activity

21048939


check buttonFusion gene breakpoints across MAPK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ARHGEF7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-69-7979-01AMAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
ChimerDB4LUADTCGA-69-7979-01AMAPK1chr22

22221612

-ARHGEF7chr13

111870026

+


Top

Fusion Gene ORF analysis for MAPK1-ARHGEF7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000215832ENST00000218789MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-5UTRENST00000215832ENST00000218789MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000215832ENST00000375723MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000215832ENST00000375736MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-5UTRENST00000215832ENST00000375736MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000215832ENST00000375737MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000215832ENST00000426073MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000215832ENST00000544132MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-5UTRENST00000215832ENST00000544132MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000398822ENST00000218789MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-5UTRENST00000398822ENST00000218789MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000398822ENST00000375723MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000398822ENST00000375736MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-5UTRENST00000398822ENST00000375736MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000398822ENST00000375737MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000398822ENST00000426073MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000398822ENST00000544132MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-5UTRENST00000398822ENST00000544132MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000544786ENST00000218789MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-5UTRENST00000544786ENST00000218789MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000544786ENST00000375723MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000544786ENST00000375736MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-5UTRENST00000544786ENST00000375736MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000544786ENST00000375737MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000544786ENST00000426073MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-5UTRENST00000544786ENST00000544132MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-5UTRENST00000544786ENST00000544132MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-intronENST00000215832ENST00000370623MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000215832ENST00000375723MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000215832ENST00000375737MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000215832ENST00000375739MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000215832ENST00000426073MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000215832ENST00000478679MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000215832ENST00000478679MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-intronENST00000215832ENST00000483189MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000215832ENST00000483189MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-intronENST00000398822ENST00000370623MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000398822ENST00000375723MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000398822ENST00000375737MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000398822ENST00000375739MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000398822ENST00000426073MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000398822ENST00000478679MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000398822ENST00000478679MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-intronENST00000398822ENST00000483189MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000398822ENST00000483189MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-intronENST00000544786ENST00000370623MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000544786ENST00000375723MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000544786ENST00000375737MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000544786ENST00000375739MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000544786ENST00000426073MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000544786ENST00000478679MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000544786ENST00000478679MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
5CDS-intronENST00000544786ENST00000483189MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
5CDS-intronENST00000544786ENST00000483189MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
In-frameENST00000215832ENST00000317133MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
In-frameENST00000215832ENST00000317133MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
In-frameENST00000215832ENST00000370623MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
In-frameENST00000215832ENST00000375739MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
In-frameENST00000215832ENST00000375741MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
In-frameENST00000215832ENST00000375741MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
In-frameENST00000398822ENST00000317133MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
In-frameENST00000398822ENST00000317133MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
In-frameENST00000398822ENST00000370623MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
In-frameENST00000398822ENST00000375739MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
In-frameENST00000398822ENST00000375741MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
In-frameENST00000398822ENST00000375741MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
In-frameENST00000544786ENST00000317133MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
In-frameENST00000544786ENST00000317133MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
In-frameENST00000544786ENST00000370623MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
In-frameENST00000544786ENST00000375739MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
In-frameENST00000544786ENST00000375741MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
In-frameENST00000544786ENST00000375741MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
intron-3CDSENST00000491588ENST00000317133MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
intron-3CDSENST00000491588ENST00000317133MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
intron-3CDSENST00000491588ENST00000370623MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
intron-3CDSENST00000491588ENST00000375739MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
intron-3CDSENST00000491588ENST00000375741MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
intron-3CDSENST00000491588ENST00000375741MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
intron-5UTRENST00000491588ENST00000218789MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
intron-5UTRENST00000491588ENST00000218789MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
intron-5UTRENST00000491588ENST00000375723MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
intron-5UTRENST00000491588ENST00000375736MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
intron-5UTRENST00000491588ENST00000375736MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
intron-5UTRENST00000491588ENST00000375737MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
intron-5UTRENST00000491588ENST00000426073MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
intron-5UTRENST00000491588ENST00000544132MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
intron-5UTRENST00000491588ENST00000544132MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
intron-intronENST00000491588ENST00000370623MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
intron-intronENST00000491588ENST00000375723MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
intron-intronENST00000491588ENST00000375737MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
intron-intronENST00000491588ENST00000375739MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
intron-intronENST00000491588ENST00000426073MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
intron-intronENST00000491588ENST00000478679MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
intron-intronENST00000491588ENST00000478679MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+
intron-intronENST00000491588ENST00000483189MAPK1chr22

22221612

-ARHGEF7chr13

111806252

+
intron-intronENST00000491588ENST00000483189MAPK1chr22

22221612

-ARHGEF7chr13

111870026

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000215832MAPK1chr2222221612-ENST00000317133ARHGEF7chr13111870026+32933081042188694
ENST00000215832MAPK1chr2222221612-ENST00000375741ARHGEF7chr13111870026+50523081042188694
ENST00000215832MAPK1chr2222221612-ENST00000375739ARHGEF7chr13111870026+50523081042188694
ENST00000215832MAPK1chr2222221612-ENST00000370623ARHGEF7chr13111870026+48703081042251715
ENST00000398822MAPK1chr2222221612-ENST00000317133ARHGEF7chr13111870026+3344359382239733
ENST00000398822MAPK1chr2222221612-ENST00000375741ARHGEF7chr13111870026+5103359382239733
ENST00000398822MAPK1chr2222221612-ENST00000375739ARHGEF7chr13111870026+5103359382239733
ENST00000398822MAPK1chr2222221612-ENST00000370623ARHGEF7chr13111870026+4921359382302754
ENST00000544786MAPK1chr2222221612-ENST00000317133ARHGEF7chr13111870026+31041191221999625
ENST00000544786MAPK1chr2222221612-ENST00000375741ARHGEF7chr13111870026+48631191221999625
ENST00000544786MAPK1chr2222221612-ENST00000375739ARHGEF7chr13111870026+48631191221999625
ENST00000544786MAPK1chr2222221612-ENST00000370623ARHGEF7chr13111870026+46811191222062646
ENST00000215832MAPK1chr2222221612-ENST00000317133ARHGEF7chr13111806252+35963081042491795
ENST00000215832MAPK1chr2222221612-ENST00000375741ARHGEF7chr13111806252+54183081042554816
ENST00000398822MAPK1chr2222221612-ENST00000317133ARHGEF7chr13111806252+3647359382542834
ENST00000398822MAPK1chr2222221612-ENST00000375741ARHGEF7chr13111806252+5469359382605855
ENST00000544786MAPK1chr2222221612-ENST00000317133ARHGEF7chr13111806252+34071191522302716
ENST00000544786MAPK1chr2222221612-ENST00000375741ARHGEF7chr13111806252+52291191522365737

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000215832ENST00000317133MAPK1chr2222221612-ARHGEF7chr13111870026+0.0044282250.99557173
ENST00000215832ENST00000375741MAPK1chr2222221612-ARHGEF7chr13111870026+0.0015134860.9984865
ENST00000215832ENST00000375739MAPK1chr2222221612-ARHGEF7chr13111870026+0.0015134860.9984865
ENST00000215832ENST00000370623MAPK1chr2222221612-ARHGEF7chr13111870026+0.0011352110.99886477
ENST00000398822ENST00000317133MAPK1chr2222221612-ARHGEF7chr13111870026+0.0052227690.9947772
ENST00000398822ENST00000375741MAPK1chr2222221612-ARHGEF7chr13111870026+0.0016969930.99830294
ENST00000398822ENST00000375739MAPK1chr2222221612-ARHGEF7chr13111870026+0.0016969930.99830294
ENST00000398822ENST00000370623MAPK1chr2222221612-ARHGEF7chr13111870026+0.0012654810.99873453
ENST00000544786ENST00000317133MAPK1chr2222221612-ARHGEF7chr13111870026+0.00292320.99707687
ENST00000544786ENST00000375741MAPK1chr2222221612-ARHGEF7chr13111870026+0.0011540390.99884593
ENST00000544786ENST00000375739MAPK1chr2222221612-ARHGEF7chr13111870026+0.0011540390.99884593
ENST00000544786ENST00000370623MAPK1chr2222221612-ARHGEF7chr13111870026+0.0008857970.9991142
ENST00000215832ENST00000317133MAPK1chr2222221612-ARHGEF7chr13111806252+0.0041806550.99581933
ENST00000215832ENST00000375741MAPK1chr2222221612-ARHGEF7chr13111806252+0.001512480.9984875
ENST00000398822ENST00000317133MAPK1chr2222221612-ARHGEF7chr13111806252+0.0049437460.9950563
ENST00000398822ENST00000375741MAPK1chr2222221612-ARHGEF7chr13111806252+0.0016929560.998307
ENST00000544786ENST00000317133MAPK1chr2222221612-ARHGEF7chr13111806252+0.002839960.9971601
ENST00000544786ENST00000375741MAPK1chr2222221612-ARHGEF7chr13111806252+0.001162870.9988372

Top

Fusion Genomic Features for MAPK1-ARHGEF7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MAPK1-ARHGEF7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:22221612/chr13:111870026)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAPK1chr22:22221612chr13:111806252ENST00000215832-192_9393486.3333333333335Compositional biasNote=Poly-Ala
HgeneMAPK1chr22:22221612chr13:111806252ENST00000398822-182_939361.0Compositional biasNote=Poly-Ala
HgeneMAPK1chr22:22221612chr13:111806252ENST00000544786-172_939317.0Compositional biasNote=Poly-Ala
HgeneMAPK1chr22:22221612chr13:111870026ENST00000215832-192_9393486.3333333333335Compositional biasNote=Poly-Ala
HgeneMAPK1chr22:22221612chr13:111870026ENST00000398822-182_939361.0Compositional biasNote=Poly-Ala
HgeneMAPK1chr22:22221612chr13:111870026ENST00000544786-172_939317.0Compositional biasNote=Poly-Ala
HgeneMAPK1chr22:22221612chr13:111806252ENST00000215832-1931_39393486.3333333333335Nucleotide bindingATP
HgeneMAPK1chr22:22221612chr13:111806252ENST00000398822-1831_3939361.0Nucleotide bindingATP
HgeneMAPK1chr22:22221612chr13:111806252ENST00000544786-1731_3939317.0Nucleotide bindingATP
HgeneMAPK1chr22:22221612chr13:111870026ENST00000215832-1931_39393486.3333333333335Nucleotide bindingATP
HgeneMAPK1chr22:22221612chr13:111870026ENST00000398822-1831_3939361.0Nucleotide bindingATP
HgeneMAPK1chr22:22221612chr13:111870026ENST00000544786-1731_3939317.0Nucleotide bindingATP
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000317133019184_24355783.0DomainSH3
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000317133019271_45155783.0DomainDH
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000317133019473_57855783.0DomainPH
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000370623019184_24355732.0DomainSH3
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000370623019271_45155732.0DomainDH
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000370623019473_57855732.0DomainPH
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000375723017184_2430626.0DomainSH3
TgeneARHGEF7chr22:22221612chr13:111806252ENST000003757230171_1330626.0DomainCalponin-homology (CH)
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000375723017271_4510626.0DomainDH
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000375723017473_5780626.0DomainPH
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000375736020184_2430647.0DomainSH3
TgeneARHGEF7chr22:22221612chr13:111806252ENST000003757360201_1330647.0DomainCalponin-homology (CH)
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000375736020271_4510647.0DomainDH
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000375736020473_5780647.0DomainPH
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000375739018184_2430754.0DomainSH3
TgeneARHGEF7chr22:22221612chr13:111806252ENST000003757390181_1330754.0DomainCalponin-homology (CH)
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000375739018271_4510754.0DomainDH
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000375739018473_5780754.0DomainPH
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000375741020184_24355804.0DomainSH3
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000375741020271_45155804.0DomainDH
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000375741020473_57855804.0DomainPH
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000426073020184_2430647.0DomainSH3
TgeneARHGEF7chr22:22221612chr13:111806252ENST000004260730201_1330647.0DomainCalponin-homology (CH)
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000426073020271_4510647.0DomainDH
TgeneARHGEF7chr22:22221612chr13:111806252ENST00000426073020473_5780647.0DomainPH
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000317133319184_243156783.0DomainSH3
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000317133319271_451156783.0DomainDH
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000317133319473_578156783.0DomainPH
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000370623119184_24384732.0DomainSH3
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000370623119271_45184732.0DomainDH
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000370623119473_57884732.0DomainPH
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000375723117184_2430626.0DomainSH3
TgeneARHGEF7chr22:22221612chr13:111870026ENST000003757231171_1330626.0DomainCalponin-homology (CH)
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000375723117271_4510626.0DomainDH
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000375723117473_5780626.0DomainPH
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000375736220184_2430647.0DomainSH3
TgeneARHGEF7chr22:22221612chr13:111870026ENST000003757362201_1330647.0DomainCalponin-homology (CH)
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000375736220271_4510647.0DomainDH
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000375736220473_5780647.0DomainPH
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000375739218184_243127754.0DomainSH3
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000375739218271_451127754.0DomainDH
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000375739218473_578127754.0DomainPH
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000375741420184_243177804.0DomainSH3
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000375741420271_451177804.0DomainDH
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000375741420473_578177804.0DomainPH
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000426073220184_2430647.0DomainSH3
TgeneARHGEF7chr22:22221612chr13:111870026ENST000004260732201_1330647.0DomainCalponin-homology (CH)
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000426073220271_4510647.0DomainDH
TgeneARHGEF7chr22:22221612chr13:111870026ENST00000426073220473_5780647.0DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAPK1chr22:22221612chr13:111806252ENST00000215832-19259_277393486.3333333333335DNA binding.
HgeneMAPK1chr22:22221612chr13:111806252ENST00000398822-18259_27739361.0DNA binding.
HgeneMAPK1chr22:22221612chr13:111806252ENST00000544786-17259_27739317.0DNA binding.
HgeneMAPK1chr22:22221612chr13:111870026ENST00000215832-19259_277393486.3333333333335DNA binding.
HgeneMAPK1chr22:22221612chr13:111870026ENST00000398822-18259_27739361.0DNA binding.
HgeneMAPK1chr22:22221612chr13:111870026ENST00000544786-17259_27739317.0DNA binding.
HgeneMAPK1chr22:22221612chr13:111806252ENST00000215832-1925_313393486.3333333333335DomainProtein kinase
HgeneMAPK1chr22:22221612chr13:111806252ENST00000398822-1825_31339361.0DomainProtein kinase
HgeneMAPK1chr22:22221612chr13:111806252ENST00000544786-1725_31339317.0DomainProtein kinase
HgeneMAPK1chr22:22221612chr13:111870026ENST00000215832-1925_313393486.3333333333335DomainProtein kinase
HgeneMAPK1chr22:22221612chr13:111870026ENST00000398822-1825_31339361.0DomainProtein kinase
HgeneMAPK1chr22:22221612chr13:111870026ENST00000544786-1725_31339317.0DomainProtein kinase
HgeneMAPK1chr22:22221612chr13:111806252ENST00000215832-19185_187393486.3333333333335MotifTXY
HgeneMAPK1chr22:22221612chr13:111806252ENST00000215832-19318_322393486.3333333333335MotifCytoplasmic retention motif
HgeneMAPK1chr22:22221612chr13:111806252ENST00000215832-19327_333393486.3333333333335MotifNuclear translocation motif
HgeneMAPK1chr22:22221612chr13:111806252ENST00000398822-18185_18739361.0MotifTXY
HgeneMAPK1chr22:22221612chr13:111806252ENST00000398822-18318_32239361.0MotifCytoplasmic retention motif
HgeneMAPK1chr22:22221612chr13:111806252ENST00000398822-18327_33339361.0MotifNuclear translocation motif
HgeneMAPK1chr22:22221612chr13:111806252ENST00000544786-17185_18739317.0MotifTXY
HgeneMAPK1chr22:22221612chr13:111806252ENST00000544786-17318_32239317.0MotifCytoplasmic retention motif
HgeneMAPK1chr22:22221612chr13:111806252ENST00000544786-17327_33339317.0MotifNuclear translocation motif
HgeneMAPK1chr22:22221612chr13:111870026ENST00000215832-19185_187393486.3333333333335MotifTXY
HgeneMAPK1chr22:22221612chr13:111870026ENST00000215832-19318_322393486.3333333333335MotifCytoplasmic retention motif
HgeneMAPK1chr22:22221612chr13:111870026ENST00000215832-19327_333393486.3333333333335MotifNuclear translocation motif
HgeneMAPK1chr22:22221612chr13:111870026ENST00000398822-18185_18739361.0MotifTXY
HgeneMAPK1chr22:22221612chr13:111870026ENST00000398822-18318_32239361.0MotifCytoplasmic retention motif
HgeneMAPK1chr22:22221612chr13:111870026ENST00000398822-18327_33339361.0MotifNuclear translocation motif
HgeneMAPK1chr22:22221612chr13:111870026ENST00000544786-17185_18739317.0MotifTXY
HgeneMAPK1chr22:22221612chr13:111870026ENST00000544786-17318_32239317.0MotifCytoplasmic retention motif
HgeneMAPK1chr22:22221612chr13:111870026ENST00000544786-17327_33339317.0MotifNuclear translocation motif
HgeneMAPK1chr22:22221612chr13:111806252ENST00000215832-19105_108393486.3333333333335RegionNote=Inhibitor-binding
HgeneMAPK1chr22:22221612chr13:111806252ENST00000215832-19153_154393486.3333333333335RegionNote=Inhibitor-binding
HgeneMAPK1chr22:22221612chr13:111806252ENST00000398822-18105_10839361.0RegionNote=Inhibitor-binding
HgeneMAPK1chr22:22221612chr13:111806252ENST00000398822-18153_15439361.0RegionNote=Inhibitor-binding
HgeneMAPK1chr22:22221612chr13:111806252ENST00000544786-17105_10839317.0RegionNote=Inhibitor-binding
HgeneMAPK1chr22:22221612chr13:111806252ENST00000544786-17153_15439317.0RegionNote=Inhibitor-binding
HgeneMAPK1chr22:22221612chr13:111870026ENST00000215832-19105_108393486.3333333333335RegionNote=Inhibitor-binding
HgeneMAPK1chr22:22221612chr13:111870026ENST00000215832-19153_154393486.3333333333335RegionNote=Inhibitor-binding
HgeneMAPK1chr22:22221612chr13:111870026ENST00000398822-18105_10839361.0RegionNote=Inhibitor-binding
HgeneMAPK1chr22:22221612chr13:111870026ENST00000398822-18153_15439361.0RegionNote=Inhibitor-binding
HgeneMAPK1chr22:22221612chr13:111870026ENST00000544786-17105_10839317.0RegionNote=Inhibitor-binding
HgeneMAPK1chr22:22221612chr13:111870026ENST00000544786-17153_15439317.0RegionNote=Inhibitor-binding
TgeneARHGEF7chr22:22221612chr13:111806252ENST000003171330191_13355783.0DomainCalponin-homology (CH)
TgeneARHGEF7chr22:22221612chr13:111806252ENST000003706230191_13355732.0DomainCalponin-homology (CH)
TgeneARHGEF7chr22:22221612chr13:111806252ENST000003757410201_13355804.0DomainCalponin-homology (CH)
TgeneARHGEF7chr22:22221612chr13:111870026ENST000003171333191_133156783.0DomainCalponin-homology (CH)
TgeneARHGEF7chr22:22221612chr13:111870026ENST000003706231191_13384732.0DomainCalponin-homology (CH)
TgeneARHGEF7chr22:22221612chr13:111870026ENST000003757392181_133127754.0DomainCalponin-homology (CH)
TgeneARHGEF7chr22:22221612chr13:111870026ENST000003757414201_133177804.0DomainCalponin-homology (CH)


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Fusion Gene Sequence for MAPK1-ARHGEF7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51523_51523_1_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000215832_ARHGEF7_chr13_111806252_ENST00000317133_length(transcript)=3596nt_BP=308nt
AGGCAATCGGTCCGAGTGGCTGTCGGCTCTTCAGCTCTCCCGCTCGGCGTCTTCCTTCCTCCTCCCGGTCAGCGTCGGCGGCTGCACCGG
CGGCGGCGCAGTCCCTGCGGGAGGGGCGACAAGAGCTGAGCGGCGGCCGCCGAGCGTCGAGCTCAGCGCGGCGGAGGCGGCGGCGGCCCG
GCAGCCAACATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAAC
CTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGGTCTACCCCGAGCCCCGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGT
TCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGACGTTTGATGCAAATGATTTGTATCAGGGGCAGAATTTTAACAAGGTCCTCAGTT
CCTTAGTGACTCTAAATAAAGTAACAGCAGACATCGGGCTGGGGAGTGACTCCGTGTGTGCCCGGCCCTCGTCTCACCGCATAAAGTCTT
TTGACTCCCTTGGATCACAGTCTTTGCACACTCGGACTTCAAAACTGTTCCAGGGCCAGTATCGGAGTTTGGACATGACCGATAATAGCA
ACAATCAACTGGTAGTAAGAGCAAAGTTTAACTTCCAGCAGACCAATGAGGACGAGCTTTCCTTCTCAAAAGGAGACGTCATCCATGTCA
CCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCACACTCAACGGCCGGACCGGCTGGTTCCCCAGCAACTACGTGCGCGAGGTCAAGGCCA
GCGAGAAGCCTGTGTCTCCCAAATCAGGAACACTGAAGAGCCCTCCCAAAGGATTTGATACGACTGCCATAAACAAAAGCTATTACAATG
TGGTGCTACAGAATATTTTAGAAACAGAAAATGAATATTCTAAAGAACTTCAGACTGTGCTTTCAACGTACCTACGGCCATTGCAGACCA
GTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAATGGGAAATCTAGAAGAAATATGTTCTTTCCAGCAAATGCTCGTACAGTCTTTAG
AAGAATGCACCAAGTTGCCCGAAGCTCAGCAGAGAGTCGGAGGCTGCTTTTTAAACCTGATGCCACAGATGAAAACCCTGTACCTCACGT
ATTGTGCCAATCACCCTTCTGCAGTGAATGTCCTCACGGAACACAGTGAGGAGTTGGGGGAGTTCATGGAGACCAAAGGTGCCAGCAGCC
CTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAACCCTTCATGCGCCTGGATAAATACCCTACGCTGCTCAAAGAGCTCGAGAGACACA
TGGAGGATTATCATACAGATAGACAAGATATTCAAAAATCCATGGCTGCCTTCAAAAACCTTTCAGCCCAATGTCAAGAAGTCCGGAAGA
GGAAAGAGCTTGAGCTGCAGATCCTGACGGAAGCCATCCGGAACTGGGAGGGCGATGACATTAAAACTCTGGGCAACGTCACTTACATGT
CCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAAAGAATGAAAGATATCTTCTACTCTTCCCAAATGTTTTGCTAATGTTGTCTGCCA
GTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGCTTCCAACGACAGGAATGACAATCACAAAGCTTGAGGACAGTGAAAATCATAGAA
ATGCATTTGAAATATCAGGGAGCATGATTGAGCGGATATTAGTGTCGTGCAACAACCAGCAGGATCTGCAGGAATGGGTGGAGCACCTAC
AGAAGCAAACGAAGGTCACGTCTGTGGGAAACCCCACCATAAAGCCTCATTCAGTGCCATCTCATACCCTCCCCTCCCACCCGGTCACTC
CGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGCTGACGCCCGCCTACCACACGCTGCCCCACCCCTCCCACCACGGCACCCCGCACA
CCACCATCAACTGGGGACCCCTGGAGCCTCCGAAAACACCCAAGCCCTGGAGCCTGAGCTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCT
CAGCTGCTCTCTGCTACAAGGAGGATCTTAGTAAGAGCCCTAAGACCATGAAAAAGCTGCTGCCCAAGCGCAAACCTGAACGGAAGCCTT
CAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTGCTTTGGAAGAAGATGCTCAGATTCTGAAAGTCATTGAAGCTTACTGCACCAGCG
CCAAAACAAGGCAAACACTCAATTCAACATGGCAAGGCACTGACCTGATGCATAATCACGTCTTGGCTGATGATGACCAACCAAGCCTAG
ACTCCCTGGGGCGTCGCAGTAGCCTTTCTCGTTTGGAGCCTTCAGACCTCTCGGAAGACTCTGACTATGACAGTATATGGACAGCCCATA
GTTACAGAATGGGTTCTACATCTCGTAAGAGCTGTTGCTCATATATCTCTCACCAGAACTAATGCACTTCTGAGCTTTTCTTAACAAATG
CTTGTTGTATCGCAGCCTGCTTTTCTTAGATGTTTTCTTGCTGTTCCTTGTCTCTTTTATGTGATATTTTAACAACTTTTGAGAGTGTTC
CTGATATTTCCCATTGTACTTTGTGGAGGCTTAACTGCCGATGCGAGTATACATTCGAATGACTGACTATTGGAGGGAGGTGGTGTGTTC
ACGTGAGCCTACATCCGAGGGTGCTCTTCGTAAGGGGTAGTTGTTGTTTTATAGCTCCAAATGGTTTTTTTATTCTCAGTGTAGCAACTG
TTTGATTTCTTTCTGGATACAGCTGTATGAACACTTTTCTATTTTATACTGAAATCACACAGGTTTGTGATCTAAGTGCCAGAACCATGG
AGGAGACTCTGGCCTTATCTGTAGGGACCTAAATTTTTTAAGTGCTATGAACACTGATCAAGTAGTTGTGGAGAGATGAGAAGAATATAT
GCAGCAAAGGTGCTGTGAGCCCAGTTCCAACGGCTGTGTTCTGGTAATCGTGCAGAACAGCATGTGGGCTCTGGGCCTTGGCAGGTGCAC
AGACGGGCGGGCGTCACGTGTGTTCAGAGCTTGTCTCCACCTCACGGCTCTGTGCTCTTCTGTGTGCTGCGTTGTGGCCGTGAAGTGGGA
GCTCTCCTTTCCAAAGGCAGAGCTTACTGTCATGGCTCAGATGTTCACTCGCATCTTCACCCCAAACTTCCCTGAATTGCAGTGATTTCT
GTTATAAGGCACATAGCAAGCCTGTACCACTCTACAGTAAAATCTCTACACTAACAGTTTAAAGCCCGAAAGCTGAAGCATTCAGCCTCT
GCAAGTGTAGACTACTGGACTGTAGTAGAGGCATTTGGAATACTTACAAAGTCAAGTGCTGTGGCTTCAGTTCCCCCGGCTCCCCACCCC
TGACATCCATACTTATGTTGTCTGGAAGAGCCATGGACACATCATTATTTTCAGCAACCAGCTGCAGTGAAACTCCATTTACAGCAACCC

>51523_51523_1_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000215832_ARHGEF7_chr13_111806252_ENST00000317133_length(amino acids)=795AA_BP=10
MREGRQELSGGRRASSSARRRRRRPGSQHGGGGGGGRGPGDGPRAGVRRGAALHQPLVHRRGRLRHGVVYPEPRSESECLSNIREFLRGC
GASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLV
VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQN
ILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANH
PSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELE
LQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEI
SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINW
GPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQ

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>51523_51523_2_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000215832_ARHGEF7_chr13_111806252_ENST00000375741_length(transcript)=5418nt_BP=308nt
AGGCAATCGGTCCGAGTGGCTGTCGGCTCTTCAGCTCTCCCGCTCGGCGTCTTCCTTCCTCCTCCCGGTCAGCGTCGGCGGCTGCACCGG
CGGCGGCGCAGTCCCTGCGGGAGGGGCGACAAGAGCTGAGCGGCGGCCGCCGAGCGTCGAGCTCAGCGCGGCGGAGGCGGCGGCGGCCCG
GCAGCCAACATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAAC
CTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGGTCTACCCCGAGCCCCGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGT
TCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGCTCCTGTTTCCTCCTTCCCAGCCTCCTCAGCATCTGGTAACCACCATTCTCTTGT
CTGCTTCTACGTTTGATGCAAATGATTTGTATCAGGGGCAGAATTTTAACAAGGTCCTCAGTTCCTTAGTGACTCTAAATAAAGTAACAG
CAGACATCGGGCTGGGGAGTGACTCCGTGTGTGCCCGGCCCTCGTCTCACCGCATAAAGTCTTTTGACTCCCTTGGATCACAGTCTTTGC
ACACTCGGACTTCAAAACTGTTCCAGGGCCAGTATCGGAGTTTGGACATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGT
TTAACTTCCAGCAGACCAATGAGGACGAGCTTTCCTTCTCAAAAGGAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGG
AGGGCACACTCAACGGCCGGACCGGCTGGTTCCCCAGCAACTACGTGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTGTCTCCCAAATCAG
GAACACTGAAGAGCCCTCCCAAAGGATTTGATACGACTGCCATAAACAAAAGCTATTACAATGTGGTGCTACAGAATATTTTAGAAACAG
AAAATGAATATTCTAAAGAACTTCAGACTGTGCTTTCAACGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTT
CATATTTAATGGGAAATCTAGAAGAAATATGTTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTC
AGCAGAGAGTCGGAGGCTGCTTTTTAAACCTGATGCCACAGATGAAAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGA
ATGTCCTCACGGAACACAGTGAGGAGTTGGGGGAGTTCATGGAGACCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCC
TGAGCAAACCCTTCATGCGCCTGGATAAATACCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAG
ATATTCAAAAATCCATGGCTGCCTTCAAAAACCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGA
CGGAAGCCATCCGGAACTGGGAGGGCGATGACATTAAAACTCTGGGCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAA
GTGAGGAAAAGAATGAAAGATATCTTCTACTCTTCCCAAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATC
AGGGAAAGCTTCCAACGACAGGAATGACAATCACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGA
TTGAGCGGATATTAGTGTCGTGCAACAACCAGCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGG
GAAACCCCACCATAAAGCCTCATTCAGTGCCATCTCATACCCTCCCCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGC
CCGCGCCGCTGACGCCCGCCTACCACACGCTGCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGC
CTCCGAAAACACCCAAGCCCTGGAGCCTGAGCTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATC
TTAGTAAGAGCCCTAAGACCATGAAAAAGCTGCTGCCCAAGCGCAAACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAA
GCACAGCTGCTTTGGAAGAAGATGCTCAGATTCTGAAAGTCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAA
CATGGCAAGGCACTGACCTGATGCATAATCACGTCTTGGCTGATGATGACCAACCAAGCCTAGACTCCCTGGGGCGTCGCAGTAGCCTTT
CTCGTTTGGAGCCTTCAGACCTCTCGGAAGACTCTGACTATGACAGTATATGGACAGCCCATAGTTACAGAATGGGTTCTACATCTCGTA
AGAGCTGTTGCTCATATATCTCTCACCAGAACTAATGCACTTCTGAGCTTTTCTTAACAAATGCTTGTTGTATCGCAGCCTGCTTTTCTT
AGATGTTTTCTTGCTGTTCCTTGTCTCTTTTATGTGATATTTTAACAACTTTTGAGAGTGTTCCTGATATTTCCCATTGTACTTTGTGGA
GGCTTAACTGCCGATGCGAGTATACATTCGAATGACTGACTATTGGAGGGAGGTGGTGTGTTCACGTGAGCCTACATCCGAGGGTGCTCT
TCGTAAGGGGTAGTTGTTGTTTTATAGCTCCAAATGGTTTTTTTATTCTCAGTGTAGCAACTGTTTGATTTCTTTCTGGATACAGCTGTA
TGAACACTTTTCTATTTTATACTGAAATCACACAGGTTTGTGATCTAAGTGCCAGAACCATGGAGGAGACTCTGGCCTTATCTGTAGGGA
CCTAAATTTTTTAAGTGCTATGAACACTGATCAAGTAGTTGTGGAGAGATGAGAAGAATATATGCAGCAAAGGTGCTGTGAGCCCAGTTC
CAACGGCTGTGTTCTGGTAATCGTGCAGAACAGCATGTGGGCTCTGGGCCTTGGCAGGTGCACAGACGGGCGGGCGTCACGTGTGTTCAG
AGCTTGTCTCCACCTCACGGCTCTGTGCTCTTCTGTGTGCTGCGTTGTGGCCGTGAAGTGGGAGCTCTCCTTTCCAAAGGCAGAGCTTAC
TGTCATGGCTCAGATGTTCACTCGCATCTTCACCCCAAACTTCCCTGAATTGCAGTGATTTCTGTTATAAGGCACATAGCAAGCCTGTAC
CACTCTACAGTAAAATCTCTACACTAACAGTTTAAAGCCCGAAAGCTGAAGCATTCAGCCTCTGCAAGTGTAGACTACTGGACTGTAGTA
GAGGCATTTGGAATACTTACAAAGTCAAGTGCTGTGGCTTCAGTTCCCCCGGCTCCCCACCCCTGACATCCATACTTATGTTGTCTGGAA
GAGCCATGGACACATCATTATTTTCAGCAACCAGCTGCAGTGAAACTCCATTTACAGCAACCCCATAGTATAAAACCACAATGCCTCATT
GTAATGGGATATTGAAGTTCATTGAAGAATTACTAGGTTGCCATGTGGCTCACTTATTTAAAAAAAAAAAAAAAAAACTCACCCGTTTTC
CTGGGATTTGTTGTAAGGAGTTTTCACTGGCCTCACTCAGACCAATTTCTGCTTCAAAAAGCACTGAATGTGACCTGTTGCATTCAGTTG
TAGCATCAAATCCACACCTAGTCATTGCTTGAGGGGCCAAATTGTGTTCTGTCCCATGCACGCTCTATTTGGTGTTAAAATGGAACCTTA
CGGTTGTGTTTTAAGTATTCATTGAAACCAGCTTCAGAAAACAAGATGCCATAGTAAATTGAGAATAACATTTTTTCCTTCTTCAGGGTG
GCTGTAATTCCAGGTGGCCGTGATTTCTTTCTTCCCCACTGCCCACTCCTTCGCCAAACCCACGTATTCAGTGTTCTGATCTTGTTTGTG
CAGAGTGAACTCTGATGCAGTATCAGTCTTGTCCTGGGAGCCGGGTCCTGCTGCTCACAAGCCCAGAGCTGCCAGGGAGCTCCTGGCAGT
AGCACGTTGTTTAGAAAGTTGGGTGGCTTCATTCAGCATGGAACAAGCTAATGGCACAGGAGACATCAGGGCAGCTGTTAATTCCAAATA
TTTGTTCCCAAGTAGCTACTGAACTGCTCACACCATTGGAAGATTTTGTATTTTCATACCAATTAGTAAAAATAAGAACATTGAGGAGCA
GTCAGAGCCCAGTGTTAATCTCCGGCAGAGATGGGGTTTATGTATGTTCAGCCAGATAGTAAATGGGATTTTTGGAGAAATAAGATAACT
ACAAAGTTTCTATACTTACTATAAGTGGATTTAGAAGCGATTTTGGTTTTGTATTACATACGGTAGTCCTCTGCGTCAGGGAGCACTTTT
TTGTTTGCCTCGAGACTACTCATTAGCGCACTGGCTAAGCTGCCTTTGCCTTCTCGTAGGCGTGGGTTGCCTGTGTCATGGGCTGTGTAG
ACCACAACACTCAAACACAGTTGCTGCACTTGGATTTTCCTTTAATACCAAGTATCATTTGGTTATCTTACTGGGACATTTTCATTGATA
TTCTATACACCAAAGTTTTGACGGTTTACCATCATTCCATTTTGTACCAGTTAAAGGCATTTTGATGATGCTTTTTCTTGATGCTAAGAT
CACTGCAGAAGAATAACCTGACCTTTTCTTTGCATTTGTTTTGAATGTCTAACACCATTAGCTTTTGTGATCTGGTTAAGAAGTATTAGT
GCCACAAGCCTGAAAAGACAGTTCTCCTGTGGCAGTGGCGATGTGGCATCCAGAGGGCCATTGTTTCTACTTTTGTGGGACTTCAGTCAT
GCTGATAATAGAATCTTCTGTTCATACAATTCTGTAATATTTATTTGTACAGTTAGTATTCTAATGAAAGGATGAAGAGTCTGAACTAGA
AGGTAGGTTTAAGCCATCACCAGGCCTTTGCAAATGGCCTAAATGGTGTTCCCTTTGAAATAACGCTTGCCACAAGTATATAATAAGCTA
TATTAATTGTGTTTTGCATAAAATTGCCAAAACACAGTAATGTGTATATAGTGGTATAAGATCTTGAAAAAAATCTCTATAATTGTGCTC
TTTATCTGTGAATGGGAAAAGCCATTTTTAGTAGGTGACTACCATTTGAAAAACTCAATTGGATGTATATCTGAATGTTGCATTGTATTG
TACAGTATGCATATTATTGTTTGTGGTTGCATATGGCAATGAAGTGTTTGTTTTATATTAAAAAAAACCTGTTATGTACAGTTGAAATAA

>51523_51523_2_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000215832_ARHGEF7_chr13_111806252_ENST00000375741_length(amino acids)=816AA_BP=10
MREGRQELSGGRRASSSARRRRRRPGSQHGGGGGGGRGPGDGPRAGVRRGAALHQPLVHRRGRLRHGVVYPEPRSESECLSNIREFLRGC
GASLRLELLFPPSQPPQHLVTTILLSASTFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTS
KLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKS
PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVG
GCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKS
MAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLP
TTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLT
PAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAAL
EEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRKSCCS

--------------------------------------------------------------
>51523_51523_3_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000215832_ARHGEF7_chr13_111870026_ENST00000317133_length(transcript)=3293nt_BP=308nt
AGGCAATCGGTCCGAGTGGCTGTCGGCTCTTCAGCTCTCCCGCTCGGCGTCTTCCTTCCTCCTCCCGGTCAGCGTCGGCGGCTGCACCGG
CGGCGGCGCAGTCCCTGCGGGAGGGGCGACAAGAGCTGAGCGGCGGCCGCCGAGCGTCGAGCTCAGCGCGGCGGAGGCGGCGGCGGCCCG
GCAGCCAACATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAAC
CTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGGACATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGTTTAACT
TCCAGCAGACCAATGAGGACGAGCTTTCCTTCTCAAAAGGAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCA
CACTCAACGGCCGGACCGGCTGGTTCCCCAGCAACTACGTGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTGTCTCCCAAATCAGGAACAC
TGAAGAGCCCTCCCAAAGGATTTGATACGACTGCCATAAACAAAAGCTATTACAATGTGGTGCTACAGAATATTTTAGAAACAGAAAATG
AATATTCTAAAGAACTTCAGACTGTGCTTTCAACGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATT
TAATGGGAAATCTAGAAGAAATATGTTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGA
GAGTCGGAGGCTGCTTTTTAAACCTGATGCCACAGATGAAAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCC
TCACGGAACACAGTGAGGAGTTGGGGGAGTTCATGGAGACCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCA
AACCCTTCATGCGCCTGGATAAATACCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTC
AAAAATCCATGGCTGCCTTCAAAAACCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAG
CCATCCGGAACTGGGAGGGCGATGACATTAAAACTCTGGGCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGG
AAAAGAATGAAAGATATCTTCTACTCTTCCCAAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAA
AGCTTCCAACGACAGGAATGACAATCACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGC
GGATATTAGTGTCGTGCAACAACCAGCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACC
CCACCATAAAGCCTCATTCAGTGCCATCTCATACCCTCCCCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGC
CGCTGACGCCCGCCTACCACACGCTGCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGA
AAACACCCAAGCCCTGGAGCCTGAGCTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTA
AGAGCCCTAAGACCATGAAAAAGCTGCTGCCCAAGCGCAAACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAG
CTGCTTTGGAAGAAGATGCTCAGATTCTGAAAGTCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAACATGGC
AAGGCACTGACCTGATGCATAATCACGTCTTGGCTGATGATGACCAACCAAGCCTAGACTCCCTGGGGCGTCGCAGTAGCCTTTCTCGTT
TGGAGCCTTCAGACCTCTCGGAAGACTCTGACTATGACAGTATATGGACAGCCCATAGTTACAGAATGGGTTCTACATCTCGTAAGAGCT
GTTGCTCATATATCTCTCACCAGAACTAATGCACTTCTGAGCTTTTCTTAACAAATGCTTGTTGTATCGCAGCCTGCTTTTCTTAGATGT
TTTCTTGCTGTTCCTTGTCTCTTTTATGTGATATTTTAACAACTTTTGAGAGTGTTCCTGATATTTCCCATTGTACTTTGTGGAGGCTTA
ACTGCCGATGCGAGTATACATTCGAATGACTGACTATTGGAGGGAGGTGGTGTGTTCACGTGAGCCTACATCCGAGGGTGCTCTTCGTAA
GGGGTAGTTGTTGTTTTATAGCTCCAAATGGTTTTTTTATTCTCAGTGTAGCAACTGTTTGATTTCTTTCTGGATACAGCTGTATGAACA
CTTTTCTATTTTATACTGAAATCACACAGGTTTGTGATCTAAGTGCCAGAACCATGGAGGAGACTCTGGCCTTATCTGTAGGGACCTAAA
TTTTTTAAGTGCTATGAACACTGATCAAGTAGTTGTGGAGAGATGAGAAGAATATATGCAGCAAAGGTGCTGTGAGCCCAGTTCCAACGG
CTGTGTTCTGGTAATCGTGCAGAACAGCATGTGGGCTCTGGGCCTTGGCAGGTGCACAGACGGGCGGGCGTCACGTGTGTTCAGAGCTTG
TCTCCACCTCACGGCTCTGTGCTCTTCTGTGTGCTGCGTTGTGGCCGTGAAGTGGGAGCTCTCCTTTCCAAAGGCAGAGCTTACTGTCAT
GGCTCAGATGTTCACTCGCATCTTCACCCCAAACTTCCCTGAATTGCAGTGATTTCTGTTATAAGGCACATAGCAAGCCTGTACCACTCT
ACAGTAAAATCTCTACACTAACAGTTTAAAGCCCGAAAGCTGAAGCATTCAGCCTCTGCAAGTGTAGACTACTGGACTGTAGTAGAGGCA
TTTGGAATACTTACAAAGTCAAGTGCTGTGGCTTCAGTTCCCCCGGCTCCCCACCCCTGACATCCATACTTATGTTGTCTGGAAGAGCCA
TGGACACATCATTATTTTCAGCAACCAGCTGCAGTGAAACTCCATTTACAGCAACCCCATAGTATAAAACCACAATGCCTCATTGTAATG

>51523_51523_3_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000215832_ARHGEF7_chr13_111870026_ENST00000317133_length(amino acids)=694AA_BP=10
MREGRQELSGGRRASSSARRRRRRPGSQHGGGGGGGRGPGDGPRAGVRRGAALHQPLVHRRGRLRHGVDMTDNSNNQLVVRAKFNFQQTN
EDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKE
LQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHS
EELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNW
EGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVS
CNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKP
WSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDL

--------------------------------------------------------------
>51523_51523_4_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000215832_ARHGEF7_chr13_111870026_ENST00000370623_length(transcript)=4870nt_BP=308nt
AGGCAATCGGTCCGAGTGGCTGTCGGCTCTTCAGCTCTCCCGCTCGGCGTCTTCCTTCCTCCTCCCGGTCAGCGTCGGCGGCTGCACCGG
CGGCGGCGCAGTCCCTGCGGGAGGGGCGACAAGAGCTGAGCGGCGGCCGCCGAGCGTCGAGCTCAGCGCGGCGGAGGCGGCGGCGGCCCG
GCAGCCAACATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAAC
CTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGGACATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGTTTAACT
TCCAGCAGACCAATGAGGACGAGCTTTCCTTCTCAAAAGGAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCA
CACTCAACGGCCGGACCGGCTGGTTCCCCAGCAACTACGTGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTGTCTCCCAAATCAGGAACAC
TGAAGAGCCCTCCCAAAGGATTTGATACGACTGCCATAAACAAAAGCTATTACAATGTGGTGCTACAGAATATTTTAGAAACAGAAAATG
AATATTCTAAAGAACTTCAGACTGTGCTTTCAACGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATT
TAATGGGAAATCTAGAAGAAATATGTTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGA
GAGTCGGAGGCTGCTTTTTAAACCTGATGCCACAGATGAAAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCC
TCACGGAACACAGTGAGGAGTTGGGGGAGTTCATGGAGACCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCA
AACCCTTCATGCGCCTGGATAAATACCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTC
AAAAATCCATGGCTGCCTTCAAAAACCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAG
CCATCCGGAACTGGGAGGGCGATGACATTAAAACTCTGGGCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGG
AAAAGAATGAAAGATATCTTCTACTCTTCCCAAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAA
AGCTTCCAACGACAGGAATGACAATCACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGC
GGATATTAGTGTCGTGCAACAACCAGCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACC
CCACCATAAAGCCTCATTCAGTGCCATCTCATACCCTCCCCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGC
CGCTGACGCCCGCCTACCACACGCTGCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGA
AAACACCCAAGCCCTGGAGCCTGAGCTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTA
AGAGCCCTAAGACCATGAAAAAGCTGCTGCCCAAGCGCAAACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAG
CTGCTTTGGAAGAAGATGCTCAGATTCTGAAAGTCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAAGTTCAC
GCAAAGAATCTGCTCCACAAGTTTTGCTTCCAGAAGAAGAGAAAATTATAGTGGAAGAAACTAAAAGTAATGGTCAGACAGTGATAGAAG
AAAAGAGTCTTGTGGATACCGTATATGCATTAAAGGATGAAGTTCAAGAATTAAGACAGGACAACAAAAAGATGAAGAAATCTCTAGAGG
AAGAACAGAGAGCCCGCAAAGACCTGGAGAAGCTGGTGAGGAAAGTCCTGAAGAACATGAATGATCCTGCCTGGGATGAGACCAATCTAT
AAGGGATGTCCTCAGTTCTTTCTGTTGAAGACCAGTTCTGAGGTGAAGCTGGGCACCCCTGACCCAAGTCGGGGTGCACTCAGGACCACA
GGGCAGGGCTGGGTGGGGCGCCACCTTGCTCTCTGTATATAGAAAAGCTGGAGCTTATTCTGCGAATGGAGACGATCAAACCATGACTGA
TGAATCCAGACAGGAGGGATTGACTCTGAGGACCTGAGCTACATCAATCCACTCTGTGAACATCTCAGTTACCTCATTCTGCAATAAGTT
CAGTGACTGACTAAAAGTCTTGTTTTTCCAGACTTTGAATTGAATATATAAATATTATATATACATGTTTCTTGTAAATATCCCATTTTG
AATGCATACCTGTGGTGGTTCTGTCCGGGCTAATCCCCATGCTAGAATGTCCTTTCCAGCTACGTGAATAAGAAGTCCCATGCCCGCATC
CACCGGAAGCAGAAGCCTGGTGGATGCCTGGTTCGTTCCGCAGCACCAGGGCCTCCACCGTGCTGTGGCAGCACCCCCCATGTCGGTATT
TCTAAATAACCTTATTTATACCTGCAGAGATACACTTCAGTCCCATTCAGAAGTCTTCTCTTAAAGCAGCATTACAGTCCCAGACCTGCG
GGTTTCTGAGGGCAACTTGCTGGCTGACAGACTCAGTCTTGACCTCAAGGAAGGCCCATACGGCACTGCCGCATCCACCTAGAGGTGTTT
GCTCTTGTCCGCTGTCTGAGTACTGTGATTCTCAGATGAGTTTGCTGCGTTTTGGGAGGACACAGACGGTTCTGTATAGGCTAGTTCAGT
AACAACAAAATACACTGTTTTGTCTTCCCTCAAAGAGAGATCTTACTAGAACCTGTAAATAGAATGTATTATTTATTATAAGTCACTGCA
GCTGATGAAAACAGATGGAGGCCATGCTGCAGGCTGATACTGATGGGTGGAGTTTTGTCATCAGGCCAGCCTCATCCCGAGGTCTCCTCC
ACCATTGGCCGTAGCCAGCAGGCTTCAGTGCTCACCGAAAGTAAAATCCCCTCCTTCAGCAAGAATAAAGCAATATACACCTTAGGTTCC
ACTAAGTAACATAGGCATAAGCAGGGAACGTTTCCCCCACTGTGTTCCAGTGCAGAGGAGACGAAGCCTGTCCTCACCGCGGCTCGCTGG
GCCCAGGCTGGCTCTGGAAAGCCTGTGCGGTCCTGGGCAGGAAGCCCGGCCCGTGGAGCAGGTTTTCGTTCTGCTTCAGCAATAAATAAG
GGTGACCACAGGGACTTTGCTTTTGGTTTCCTTTCCTGTGAAAAGGTTGGTTTTAAAGTGAGATACACTTTTCCGTAGAACAAGTGTTCT
ATCTTTAAAAACCCAAATTGCAGCACCGTGGATTACTGGTCTCAGAACAACTCATTGCGCATCAGATTTGACTCTCTGATTTTCTGTCTA
TTGGCCAAATTGCCCTTTAACTGCACCTGAATCCTTTGTGTACTGATGCCTTTGAGCTGGGCACCTTGGGAGAGTGTTGTGTTGCTGTTT
ACGGTTCTTCCTTGCCCTTGCTAATTACAGTCTCTGGTGCCCAGCAAGCCCCTTTGGCTTCCTTCCGTGACTGGTCACGTTGTCTGCCTG
GGCTCAGCGTGGACCTGCCCCATGCTGCAGAACCTGGCCTCACCTGGACTTTTCACTAGAATTGCCAGCTTCCTCAACTTAGCAGATCAT
TCACTCATGCGGGCACAAGCAAAGATCAACACTTTCTTTTTTGGTAAGCTTGAGTTTTACAAGTTATTTTTTGGTGATGCGTAAGACATT
GCAGTGGGAAACCATTCAACTTGAGTTTATTGGAGTTTGCTGTTGTAGCAGGTTTTAACTCAGGAACAACTCTTGTCTGATCTCTCCGCC
CCTCTGCCGGGAGGCGACATTAACTGTCCTCTCGGAGCCGGTAGCGTTGCTGTCCGAGTCCCCAGGACGGATCTCCTGCAGACCTGCCTT
AATGCTCAGATCGAAGTATTTCACAAGAATACTTGTGTTTTTAACAGCCCTTCCCCTGGACGGTGCGGCCATGAGGGCCTCATGTTACGG
CATTGCCTTTTCTTTCTGTGGATCCAGTATCTTCCTCGGCTTTTTAGGGAGCAGGAAAAATGCGTCTGAGAGCAACTCTTTTTAAAAACC
TGCCCTGTTGTATATAACTGTGTCTGTTTCACCGTGTGACCTCCCAAGGGGGTGGGAACTTGATATAAACGTTTAAAGGGGCCACGATTT
GCCCGAGGGTTACTCCTTTGCTCTCACCTTGTATGGATGAGGAGATGAAGCCATTTCTTATCCTGTAGATGTGAAGCACTTTCAGTTTTC
AGCGATGTTGGAATGTAGCATCAGAAGCTCGTTCCTTCACACTCAGTGGCGTCTGTGCTTGTCCACATGCGCTGGGCGTCTGGGACCTTG
AATGCCTGCCCTGGTTGTGTGGACTCCTTAATGCCAATCATTTCTTCACTTCTCTGGGACACCCAGGGCGCCTGTTGACAAGTGTGGAGA
AACTCCTAATTTAAATGTCACAGACAATGTCCTAGTGTTGACTACTACAATGTTGATGCTACACTGTTGTAATTATTAAACTGATTATTT

>51523_51523_4_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000215832_ARHGEF7_chr13_111870026_ENST00000370623_length(amino acids)=715AA_BP=10
MREGRQELSGGRRASSSARRRRRRPGSQHGGGGGGGRGPGDGPRAGVRRGAALHQPLVHRRGRLRHGVDMTDNSNNQLVVRAKFNFQQTN
EDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKE
LQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHS
EELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNW
EGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVS
CNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKP
WSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSSSRKESA

--------------------------------------------------------------
>51523_51523_5_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000215832_ARHGEF7_chr13_111870026_ENST00000375739_length(transcript)=5052nt_BP=308nt
AGGCAATCGGTCCGAGTGGCTGTCGGCTCTTCAGCTCTCCCGCTCGGCGTCTTCCTTCCTCCTCCCGGTCAGCGTCGGCGGCTGCACCGG
CGGCGGCGCAGTCCCTGCGGGAGGGGCGACAAGAGCTGAGCGGCGGCCGCCGAGCGTCGAGCTCAGCGCGGCGGAGGCGGCGGCGGCCCG
GCAGCCAACATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAAC
CTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGGACATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGTTTAACT
TCCAGCAGACCAATGAGGACGAGCTTTCCTTCTCAAAAGGAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCA
CACTCAACGGCCGGACCGGCTGGTTCCCCAGCAACTACGTGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTGTCTCCCAAATCAGGAACAC
TGAAGAGCCCTCCCAAAGGATTTGATACGACTGCCATAAACAAAAGCTATTACAATGTGGTGCTACAGAATATTTTAGAAACAGAAAATG
AATATTCTAAAGAACTTCAGACTGTGCTTTCAACGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATT
TAATGGGAAATCTAGAAGAAATATGTTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGA
GAGTCGGAGGCTGCTTTTTAAACCTGATGCCACAGATGAAAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCC
TCACGGAACACAGTGAGGAGTTGGGGGAGTTCATGGAGACCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCA
AACCCTTCATGCGCCTGGATAAATACCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTC
AAAAATCCATGGCTGCCTTCAAAAACCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAG
CCATCCGGAACTGGGAGGGCGATGACATTAAAACTCTGGGCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGG
AAAAGAATGAAAGATATCTTCTACTCTTCCCAAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAA
AGCTTCCAACGACAGGAATGACAATCACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGC
GGATATTAGTGTCGTGCAACAACCAGCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACC
CCACCATAAAGCCTCATTCAGTGCCATCTCATACCCTCCCCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGC
CGCTGACGCCCGCCTACCACACGCTGCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGA
AAACACCCAAGCCCTGGAGCCTGAGCTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTA
AGAGCCCTAAGACCATGAAAAAGCTGCTGCCCAAGCGCAAACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAG
CTGCTTTGGAAGAAGATGCTCAGATTCTGAAAGTCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAACATGGC
AAGGCACTGACCTGATGCATAATCACGTCTTGGCTGATGATGACCAACCAAGCCTAGACTCCCTGGGGCGTCGCAGTAGCCTTTCTCGTT
TGGAGCCTTCAGACCTCTCGGAAGACTCTGACTATGACAGTATATGGACAGCCCATAGTTACAGAATGGGTTCTACATCTCGTAAGAGCT
GTTGCTCATATATCTCTCACCAGAACTAATGCACTTCTGAGCTTTTCTTAACAAATGCTTGTTGTATCGCAGCCTGCTTTTCTTAGATGT
TTTCTTGCTGTTCCTTGTCTCTTTTATGTGATATTTTAACAACTTTTGAGAGTGTTCCTGATATTTCCCATTGTACTTTGTGGAGGCTTA
ACTGCCGATGCGAGTATACATTCGAATGACTGACTATTGGAGGGAGGTGGTGTGTTCACGTGAGCCTACATCCGAGGGTGCTCTTCGTAA
GGGGTAGTTGTTGTTTTATAGCTCCAAATGGTTTTTTTATTCTCAGTGTAGCAACTGTTTGATTTCTTTCTGGATACAGCTGTATGAACA
CTTTTCTATTTTATACTGAAATCACACAGGTTTGTGATCTAAGTGCCAGAACCATGGAGGAGACTCTGGCCTTATCTGTAGGGACCTAAA
TTTTTTAAGTGCTATGAACACTGATCAAGTAGTTGTGGAGAGATGAGAAGAATATATGCAGCAAAGGTGCTGTGAGCCCAGTTCCAACGG
CTGTGTTCTGGTAATCGTGCAGAACAGCATGTGGGCTCTGGGCCTTGGCAGGTGCACAGACGGGCGGGCGTCACGTGTGTTCAGAGCTTG
TCTCCACCTCACGGCTCTGTGCTCTTCTGTGTGCTGCGTTGTGGCCGTGAAGTGGGAGCTCTCCTTTCCAAAGGCAGAGCTTACTGTCAT
GGCTCAGATGTTCACTCGCATCTTCACCCCAAACTTCCCTGAATTGCAGTGATTTCTGTTATAAGGCACATAGCAAGCCTGTACCACTCT
ACAGTAAAATCTCTACACTAACAGTTTAAAGCCCGAAAGCTGAAGCATTCAGCCTCTGCAAGTGTAGACTACTGGACTGTAGTAGAGGCA
TTTGGAATACTTACAAAGTCAAGTGCTGTGGCTTCAGTTCCCCCGGCTCCCCACCCCTGACATCCATACTTATGTTGTCTGGAAGAGCCA
TGGACACATCATTATTTTCAGCAACCAGCTGCAGTGAAACTCCATTTACAGCAACCCCATAGTATAAAACCACAATGCCTCATTGTAATG
GGATATTGAAGTTCATTGAAGAATTACTAGGTTGCCATGTGGCTCACTTATTTAAAAAAAAAAAAAAAAAACTCACCCGTTTTCCTGGGA
TTTGTTGTAAGGAGTTTTCACTGGCCTCACTCAGACCAATTTCTGCTTCAAAAAGCACTGAATGTGACCTGTTGCATTCAGTTGTAGCAT
CAAATCCACACCTAGTCATTGCTTGAGGGGCCAAATTGTGTTCTGTCCCATGCACGCTCTATTTGGTGTTAAAATGGAACCTTACGGTTG
TGTTTTAAGTATTCATTGAAACCAGCTTCAGAAAACAAGATGCCATAGTAAATTGAGAATAACATTTTTTCCTTCTTCAGGGTGGCTGTA
ATTCCAGGTGGCCGTGATTTCTTTCTTCCCCACTGCCCACTCCTTCGCCAAACCCACGTATTCAGTGTTCTGATCTTGTTTGTGCAGAGT
GAACTCTGATGCAGTATCAGTCTTGTCCTGGGAGCCGGGTCCTGCTGCTCACAAGCCCAGAGCTGCCAGGGAGCTCCTGGCAGTAGCACG
TTGTTTAGAAAGTTGGGTGGCTTCATTCAGCATGGAACAAGCTAATGGCACAGGAGACATCAGGGCAGCTGTTAATTCCAAATATTTGTT
CCCAAGTAGCTACTGAACTGCTCACACCATTGGAAGATTTTGTATTTTCATACCAATTAGTAAAAATAAGAACATTGAGGAGCAGTCAGA
GCCCAGTGTTAATCTCCGGCAGAGATGGGGTTTATGTATGTTCAGCCAGATAGTAAATGGGATTTTTGGAGAAATAAGATAACTACAAAG
TTTCTATACTTACTATAAGTGGATTTAGAAGCGATTTTGGTTTTGTATTACATACGGTAGTCCTCTGCGTCAGGGAGCACTTTTTTGTTT
GCCTCGAGACTACTCATTAGCGCACTGGCTAAGCTGCCTTTGCCTTCTCGTAGGCGTGGGTTGCCTGTGTCATGGGCTGTGTAGACCACA
ACACTCAAACACAGTTGCTGCACTTGGATTTTCCTTTAATACCAAGTATCATTTGGTTATCTTACTGGGACATTTTCATTGATATTCTAT
ACACCAAAGTTTTGACGGTTTACCATCATTCCATTTTGTACCAGTTAAAGGCATTTTGATGATGCTTTTTCTTGATGCTAAGATCACTGC
AGAAGAATAACCTGACCTTTTCTTTGCATTTGTTTTGAATGTCTAACACCATTAGCTTTTGTGATCTGGTTAAGAAGTATTAGTGCCACA
AGCCTGAAAAGACAGTTCTCCTGTGGCAGTGGCGATGTGGCATCCAGAGGGCCATTGTTTCTACTTTTGTGGGACTTCAGTCATGCTGAT
AATAGAATCTTCTGTTCATACAATTCTGTAATATTTATTTGTACAGTTAGTATTCTAATGAAAGGATGAAGAGTCTGAACTAGAAGGTAG
GTTTAAGCCATCACCAGGCCTTTGCAAATGGCCTAAATGGTGTTCCCTTTGAAATAACGCTTGCCACAAGTATATAATAAGCTATATTAA
TTGTGTTTTGCATAAAATTGCCAAAACACAGTAATGTGTATATAGTGGTATAAGATCTTGAAAAAAATCTCTATAATTGTGCTCTTTATC
TGTGAATGGGAAAAGCCATTTTTAGTAGGTGACTACCATTTGAAAAACTCAATTGGATGTATATCTGAATGTTGCATTGTATTGTACAGT
ATGCATATTATTGTTTGTGGTTGCATATGGCAATGAAGTGTTTGTTTTATATTAAAAAAAACCTGTTATGTACAGTTGAAATAAATTTTG

>51523_51523_5_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000215832_ARHGEF7_chr13_111870026_ENST00000375739_length(amino acids)=694AA_BP=10
MREGRQELSGGRRASSSARRRRRRPGSQHGGGGGGGRGPGDGPRAGVRRGAALHQPLVHRRGRLRHGVDMTDNSNNQLVVRAKFNFQQTN
EDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKE
LQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHS
EELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNW
EGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVS
CNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKP
WSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDL

--------------------------------------------------------------
>51523_51523_6_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000215832_ARHGEF7_chr13_111870026_ENST00000375741_length(transcript)=5052nt_BP=308nt
AGGCAATCGGTCCGAGTGGCTGTCGGCTCTTCAGCTCTCCCGCTCGGCGTCTTCCTTCCTCCTCCCGGTCAGCGTCGGCGGCTGCACCGG
CGGCGGCGCAGTCCCTGCGGGAGGGGCGACAAGAGCTGAGCGGCGGCCGCCGAGCGTCGAGCTCAGCGCGGCGGAGGCGGCGGCGGCCCG
GCAGCCAACATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAAC
CTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGGACATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGTTTAACT
TCCAGCAGACCAATGAGGACGAGCTTTCCTTCTCAAAAGGAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCA
CACTCAACGGCCGGACCGGCTGGTTCCCCAGCAACTACGTGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTGTCTCCCAAATCAGGAACAC
TGAAGAGCCCTCCCAAAGGATTTGATACGACTGCCATAAACAAAAGCTATTACAATGTGGTGCTACAGAATATTTTAGAAACAGAAAATG
AATATTCTAAAGAACTTCAGACTGTGCTTTCAACGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATT
TAATGGGAAATCTAGAAGAAATATGTTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGA
GAGTCGGAGGCTGCTTTTTAAACCTGATGCCACAGATGAAAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCC
TCACGGAACACAGTGAGGAGTTGGGGGAGTTCATGGAGACCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCA
AACCCTTCATGCGCCTGGATAAATACCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTC
AAAAATCCATGGCTGCCTTCAAAAACCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAG
CCATCCGGAACTGGGAGGGCGATGACATTAAAACTCTGGGCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGG
AAAAGAATGAAAGATATCTTCTACTCTTCCCAAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAA
AGCTTCCAACGACAGGAATGACAATCACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGC
GGATATTAGTGTCGTGCAACAACCAGCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACC
CCACCATAAAGCCTCATTCAGTGCCATCTCATACCCTCCCCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGC
CGCTGACGCCCGCCTACCACACGCTGCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGA
AAACACCCAAGCCCTGGAGCCTGAGCTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTA
AGAGCCCTAAGACCATGAAAAAGCTGCTGCCCAAGCGCAAACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAG
CTGCTTTGGAAGAAGATGCTCAGATTCTGAAAGTCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAACATGGC
AAGGCACTGACCTGATGCATAATCACGTCTTGGCTGATGATGACCAACCAAGCCTAGACTCCCTGGGGCGTCGCAGTAGCCTTTCTCGTT
TGGAGCCTTCAGACCTCTCGGAAGACTCTGACTATGACAGTATATGGACAGCCCATAGTTACAGAATGGGTTCTACATCTCGTAAGAGCT
GTTGCTCATATATCTCTCACCAGAACTAATGCACTTCTGAGCTTTTCTTAACAAATGCTTGTTGTATCGCAGCCTGCTTTTCTTAGATGT
TTTCTTGCTGTTCCTTGTCTCTTTTATGTGATATTTTAACAACTTTTGAGAGTGTTCCTGATATTTCCCATTGTACTTTGTGGAGGCTTA
ACTGCCGATGCGAGTATACATTCGAATGACTGACTATTGGAGGGAGGTGGTGTGTTCACGTGAGCCTACATCCGAGGGTGCTCTTCGTAA
GGGGTAGTTGTTGTTTTATAGCTCCAAATGGTTTTTTTATTCTCAGTGTAGCAACTGTTTGATTTCTTTCTGGATACAGCTGTATGAACA
CTTTTCTATTTTATACTGAAATCACACAGGTTTGTGATCTAAGTGCCAGAACCATGGAGGAGACTCTGGCCTTATCTGTAGGGACCTAAA
TTTTTTAAGTGCTATGAACACTGATCAAGTAGTTGTGGAGAGATGAGAAGAATATATGCAGCAAAGGTGCTGTGAGCCCAGTTCCAACGG
CTGTGTTCTGGTAATCGTGCAGAACAGCATGTGGGCTCTGGGCCTTGGCAGGTGCACAGACGGGCGGGCGTCACGTGTGTTCAGAGCTTG
TCTCCACCTCACGGCTCTGTGCTCTTCTGTGTGCTGCGTTGTGGCCGTGAAGTGGGAGCTCTCCTTTCCAAAGGCAGAGCTTACTGTCAT
GGCTCAGATGTTCACTCGCATCTTCACCCCAAACTTCCCTGAATTGCAGTGATTTCTGTTATAAGGCACATAGCAAGCCTGTACCACTCT
ACAGTAAAATCTCTACACTAACAGTTTAAAGCCCGAAAGCTGAAGCATTCAGCCTCTGCAAGTGTAGACTACTGGACTGTAGTAGAGGCA
TTTGGAATACTTACAAAGTCAAGTGCTGTGGCTTCAGTTCCCCCGGCTCCCCACCCCTGACATCCATACTTATGTTGTCTGGAAGAGCCA
TGGACACATCATTATTTTCAGCAACCAGCTGCAGTGAAACTCCATTTACAGCAACCCCATAGTATAAAACCACAATGCCTCATTGTAATG
GGATATTGAAGTTCATTGAAGAATTACTAGGTTGCCATGTGGCTCACTTATTTAAAAAAAAAAAAAAAAAACTCACCCGTTTTCCTGGGA
TTTGTTGTAAGGAGTTTTCACTGGCCTCACTCAGACCAATTTCTGCTTCAAAAAGCACTGAATGTGACCTGTTGCATTCAGTTGTAGCAT
CAAATCCACACCTAGTCATTGCTTGAGGGGCCAAATTGTGTTCTGTCCCATGCACGCTCTATTTGGTGTTAAAATGGAACCTTACGGTTG
TGTTTTAAGTATTCATTGAAACCAGCTTCAGAAAACAAGATGCCATAGTAAATTGAGAATAACATTTTTTCCTTCTTCAGGGTGGCTGTA
ATTCCAGGTGGCCGTGATTTCTTTCTTCCCCACTGCCCACTCCTTCGCCAAACCCACGTATTCAGTGTTCTGATCTTGTTTGTGCAGAGT
GAACTCTGATGCAGTATCAGTCTTGTCCTGGGAGCCGGGTCCTGCTGCTCACAAGCCCAGAGCTGCCAGGGAGCTCCTGGCAGTAGCACG
TTGTTTAGAAAGTTGGGTGGCTTCATTCAGCATGGAACAAGCTAATGGCACAGGAGACATCAGGGCAGCTGTTAATTCCAAATATTTGTT
CCCAAGTAGCTACTGAACTGCTCACACCATTGGAAGATTTTGTATTTTCATACCAATTAGTAAAAATAAGAACATTGAGGAGCAGTCAGA
GCCCAGTGTTAATCTCCGGCAGAGATGGGGTTTATGTATGTTCAGCCAGATAGTAAATGGGATTTTTGGAGAAATAAGATAACTACAAAG
TTTCTATACTTACTATAAGTGGATTTAGAAGCGATTTTGGTTTTGTATTACATACGGTAGTCCTCTGCGTCAGGGAGCACTTTTTTGTTT
GCCTCGAGACTACTCATTAGCGCACTGGCTAAGCTGCCTTTGCCTTCTCGTAGGCGTGGGTTGCCTGTGTCATGGGCTGTGTAGACCACA
ACACTCAAACACAGTTGCTGCACTTGGATTTTCCTTTAATACCAAGTATCATTTGGTTATCTTACTGGGACATTTTCATTGATATTCTAT
ACACCAAAGTTTTGACGGTTTACCATCATTCCATTTTGTACCAGTTAAAGGCATTTTGATGATGCTTTTTCTTGATGCTAAGATCACTGC
AGAAGAATAACCTGACCTTTTCTTTGCATTTGTTTTGAATGTCTAACACCATTAGCTTTTGTGATCTGGTTAAGAAGTATTAGTGCCACA
AGCCTGAAAAGACAGTTCTCCTGTGGCAGTGGCGATGTGGCATCCAGAGGGCCATTGTTTCTACTTTTGTGGGACTTCAGTCATGCTGAT
AATAGAATCTTCTGTTCATACAATTCTGTAATATTTATTTGTACAGTTAGTATTCTAATGAAAGGATGAAGAGTCTGAACTAGAAGGTAG
GTTTAAGCCATCACCAGGCCTTTGCAAATGGCCTAAATGGTGTTCCCTTTGAAATAACGCTTGCCACAAGTATATAATAAGCTATATTAA
TTGTGTTTTGCATAAAATTGCCAAAACACAGTAATGTGTATATAGTGGTATAAGATCTTGAAAAAAATCTCTATAATTGTGCTCTTTATC
TGTGAATGGGAAAAGCCATTTTTAGTAGGTGACTACCATTTGAAAAACTCAATTGGATGTATATCTGAATGTTGCATTGTATTGTACAGT
ATGCATATTATTGTTTGTGGTTGCATATGGCAATGAAGTGTTTGTTTTATATTAAAAAAAACCTGTTATGTACAGTTGAAATAAATTTTG

>51523_51523_6_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000215832_ARHGEF7_chr13_111870026_ENST00000375741_length(amino acids)=694AA_BP=10
MREGRQELSGGRRASSSARRRRRRPGSQHGGGGGGGRGPGDGPRAGVRRGAALHQPLVHRRGRLRHGVDMTDNSNNQLVVRAKFNFQQTN
EDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKE
LQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHS
EELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNW
EGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVS
CNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKP
WSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDL

--------------------------------------------------------------
>51523_51523_7_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000398822_ARHGEF7_chr13_111806252_ENST00000317133_length(transcript)=3647nt_BP=359nt
GCCCCTCCCTCCGCCCGCCCGCCGGCCCGCCCGTCAGTCTGGCAGGCAGGCAGGCAATCGGTCCGAGTGGCTGTCGGCTCTTCAGCTCTC
CCGCTCGGCGTCTTCCTTCCTCCTCCCGGTCAGCGTCGGCGGCTGCACCGGCGGCGGCGCAGTCCCTGCGGGAGGGGCGACAAGAGCTGA
GCGGCGGCCGCCGAGCGTCGAGCTCAGCGCGGCGGAGGCGGCGGCGGCCCGGCAGCCAACATGGCGGCGGCGGCGGCGGCGGGCGCGGGC
CCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAACCTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGG
TCTACCCCGAGCCCCGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGACGT
TTGATGCAAATGATTTGTATCAGGGGCAGAATTTTAACAAGGTCCTCAGTTCCTTAGTGACTCTAAATAAAGTAACAGCAGACATCGGGC
TGGGGAGTGACTCCGTGTGTGCCCGGCCCTCGTCTCACCGCATAAAGTCTTTTGACTCCCTTGGATCACAGTCTTTGCACACTCGGACTT
CAAAACTGTTCCAGGGCCAGTATCGGAGTTTGGACATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGTTTAACTTCCAGC
AGACCAATGAGGACGAGCTTTCCTTCTCAAAAGGAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCACACTCA
ACGGCCGGACCGGCTGGTTCCCCAGCAACTACGTGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTGTCTCCCAAATCAGGAACACTGAAGA
GCCCTCCCAAAGGATTTGATACGACTGCCATAAACAAAAGCTATTACAATGTGGTGCTACAGAATATTTTAGAAACAGAAAATGAATATT
CTAAAGAACTTCAGACTGTGCTTTCAACGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAATGG
GAAATCTAGAAGAAATATGTTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGAGAGTCG
GAGGCTGCTTTTTAAACCTGATGCCACAGATGAAAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCCTCACGG
AACACAGTGAGGAGTTGGGGGAGTTCATGGAGACCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAACCCT
TCATGCGCCTGGATAAATACCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTCAAAAAT
CCATGGCTGCCTTCAAAAACCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAGCCATCC
GGAACTGGGAGGGCGATGACATTAAAACTCTGGGCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAAAGA
ATGAAAGATATCTTCTACTCTTCCCAAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGCTTC
CAACGACAGGAATGACAATCACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGCGGATAT
TAGTGTCGTGCAACAACCAGCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACCCCACCA
TAAAGCCTCATTCAGTGCCATCTCATACCCTCCCCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGCTGA
CGCCCGCCTACCACACGCTGCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGAAAACAC
CCAAGCCCTGGAGCCTGAGCTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTAAGAGCC
CTAAGACCATGAAAAAGCTGCTGCCCAAGCGCAAACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTGCTT
TGGAAGAAGATGCTCAGATTCTGAAAGTCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAACATGGCAAGGCA
CTGACCTGATGCATAATCACGTCTTGGCTGATGATGACCAACCAAGCCTAGACTCCCTGGGGCGTCGCAGTAGCCTTTCTCGTTTGGAGC
CTTCAGACCTCTCGGAAGACTCTGACTATGACAGTATATGGACAGCCCATAGTTACAGAATGGGTTCTACATCTCGTAAGAGCTGTTGCT
CATATATCTCTCACCAGAACTAATGCACTTCTGAGCTTTTCTTAACAAATGCTTGTTGTATCGCAGCCTGCTTTTCTTAGATGTTTTCTT
GCTGTTCCTTGTCTCTTTTATGTGATATTTTAACAACTTTTGAGAGTGTTCCTGATATTTCCCATTGTACTTTGTGGAGGCTTAACTGCC
GATGCGAGTATACATTCGAATGACTGACTATTGGAGGGAGGTGGTGTGTTCACGTGAGCCTACATCCGAGGGTGCTCTTCGTAAGGGGTA
GTTGTTGTTTTATAGCTCCAAATGGTTTTTTTATTCTCAGTGTAGCAACTGTTTGATTTCTTTCTGGATACAGCTGTATGAACACTTTTC
TATTTTATACTGAAATCACACAGGTTTGTGATCTAAGTGCCAGAACCATGGAGGAGACTCTGGCCTTATCTGTAGGGACCTAAATTTTTT
AAGTGCTATGAACACTGATCAAGTAGTTGTGGAGAGATGAGAAGAATATATGCAGCAAAGGTGCTGTGAGCCCAGTTCCAACGGCTGTGT
TCTGGTAATCGTGCAGAACAGCATGTGGGCTCTGGGCCTTGGCAGGTGCACAGACGGGCGGGCGTCACGTGTGTTCAGAGCTTGTCTCCA
CCTCACGGCTCTGTGCTCTTCTGTGTGCTGCGTTGTGGCCGTGAAGTGGGAGCTCTCCTTTCCAAAGGCAGAGCTTACTGTCATGGCTCA
GATGTTCACTCGCATCTTCACCCCAAACTTCCCTGAATTGCAGTGATTTCTGTTATAAGGCACATAGCAAGCCTGTACCACTCTACAGTA
AAATCTCTACACTAACAGTTTAAAGCCCGAAAGCTGAAGCATTCAGCCTCTGCAAGTGTAGACTACTGGACTGTAGTAGAGGCATTTGGA
ATACTTACAAAGTCAAGTGCTGTGGCTTCAGTTCCCCCGGCTCCCCACCCCTGACATCCATACTTATGTTGTCTGGAAGAGCCATGGACA
CATCATTATTTTCAGCAACCAGCTGCAGTGAAACTCCATTTACAGCAACCCCATAGTATAAAACCACAATGCCTCATTGTAATGGGATAT

>51523_51523_7_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000398822_ARHGEF7_chr13_111806252_ENST00000317133_length(amino acids)=834AA_BP=49
MAGRQAIGPSGCRLFSSPARRLPSSSRSASAAAPAAAQSLREGRQELSGGRRASSSARRRRRRPGSQHGGGGGGGRGPGDGPRAGVRRGA
ALHQPLVHRRGRLRHGVVYPEPRSESECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSH
RIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR
EVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQML
VQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKE
LERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLL
MLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPS
HPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKP
ERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSI

--------------------------------------------------------------
>51523_51523_8_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000398822_ARHGEF7_chr13_111806252_ENST00000375741_length(transcript)=5469nt_BP=359nt
GCCCCTCCCTCCGCCCGCCCGCCGGCCCGCCCGTCAGTCTGGCAGGCAGGCAGGCAATCGGTCCGAGTGGCTGTCGGCTCTTCAGCTCTC
CCGCTCGGCGTCTTCCTTCCTCCTCCCGGTCAGCGTCGGCGGCTGCACCGGCGGCGGCGCAGTCCCTGCGGGAGGGGCGACAAGAGCTGA
GCGGCGGCCGCCGAGCGTCGAGCTCAGCGCGGCGGAGGCGGCGGCGGCCCGGCAGCCAACATGGCGGCGGCGGCGGCGGCGGGCGCGGGC
CCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAACCTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGG
TCTACCCCGAGCCCCGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGCTCC
TGTTTCCTCCTTCCCAGCCTCCTCAGCATCTGGTAACCACCATTCTCTTGTCTGCTTCTACGTTTGATGCAAATGATTTGTATCAGGGGC
AGAATTTTAACAAGGTCCTCAGTTCCTTAGTGACTCTAAATAAAGTAACAGCAGACATCGGGCTGGGGAGTGACTCCGTGTGTGCCCGGC
CCTCGTCTCACCGCATAAAGTCTTTTGACTCCCTTGGATCACAGTCTTTGCACACTCGGACTTCAAAACTGTTCCAGGGCCAGTATCGGA
GTTTGGACATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGTTTAACTTCCAGCAGACCAATGAGGACGAGCTTTCCTTCT
CAAAAGGAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCACACTCAACGGCCGGACCGGCTGGTTCCCCAGCA
ACTACGTGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTGTCTCCCAAATCAGGAACACTGAAGAGCCCTCCCAAAGGATTTGATACGACTG
CCATAAACAAAAGCTATTACAATGTGGTGCTACAGAATATTTTAGAAACAGAAAATGAATATTCTAAAGAACTTCAGACTGTGCTTTCAA
CGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAATGGGAAATCTAGAAGAAATATGTTCTTTCC
AGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGAGAGTCGGAGGCTGCTTTTTAAACCTGATGCCAC
AGATGAAAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCCTCACGGAACACAGTGAGGAGTTGGGGGAGTTCA
TGGAGACCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAACCCTTCATGCGCCTGGATAAATACCCTACGC
TGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTCAAAAATCCATGGCTGCCTTCAAAAACCTTTCAG
CCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAGCCATCCGGAACTGGGAGGGCGATGACATTAAAA
CTCTGGGCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAAAGAATGAAAGATATCTTCTACTCTTCCCAA
ATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGCTTCCAACGACAGGAATGACAATCACAAAGC
TTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGCGGATATTAGTGTCGTGCAACAACCAGCAGGATC
TGCAGGAATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACCCCACCATAAAGCCTCATTCAGTGCCATCTCATA
CCCTCCCCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGCTGACGCCCGCCTACCACACGCTGCCCCACC
CCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGAAAACACCCAAGCCCTGGAGCCTGAGCTGCCTGC
GGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTAAGAGCCCTAAGACCATGAAAAAGCTGCTGCCCA
AGCGCAAACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTGCTTTGGAAGAAGATGCTCAGATTCTGAAAG
TCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAACATGGCAAGGCACTGACCTGATGCATAATCACGTCTTGG
CTGATGATGACCAACCAAGCCTAGACTCCCTGGGGCGTCGCAGTAGCCTTTCTCGTTTGGAGCCTTCAGACCTCTCGGAAGACTCTGACT
ATGACAGTATATGGACAGCCCATAGTTACAGAATGGGTTCTACATCTCGTAAGAGCTGTTGCTCATATATCTCTCACCAGAACTAATGCA
CTTCTGAGCTTTTCTTAACAAATGCTTGTTGTATCGCAGCCTGCTTTTCTTAGATGTTTTCTTGCTGTTCCTTGTCTCTTTTATGTGATA
TTTTAACAACTTTTGAGAGTGTTCCTGATATTTCCCATTGTACTTTGTGGAGGCTTAACTGCCGATGCGAGTATACATTCGAATGACTGA
CTATTGGAGGGAGGTGGTGTGTTCACGTGAGCCTACATCCGAGGGTGCTCTTCGTAAGGGGTAGTTGTTGTTTTATAGCTCCAAATGGTT
TTTTTATTCTCAGTGTAGCAACTGTTTGATTTCTTTCTGGATACAGCTGTATGAACACTTTTCTATTTTATACTGAAATCACACAGGTTT
GTGATCTAAGTGCCAGAACCATGGAGGAGACTCTGGCCTTATCTGTAGGGACCTAAATTTTTTAAGTGCTATGAACACTGATCAAGTAGT
TGTGGAGAGATGAGAAGAATATATGCAGCAAAGGTGCTGTGAGCCCAGTTCCAACGGCTGTGTTCTGGTAATCGTGCAGAACAGCATGTG
GGCTCTGGGCCTTGGCAGGTGCACAGACGGGCGGGCGTCACGTGTGTTCAGAGCTTGTCTCCACCTCACGGCTCTGTGCTCTTCTGTGTG
CTGCGTTGTGGCCGTGAAGTGGGAGCTCTCCTTTCCAAAGGCAGAGCTTACTGTCATGGCTCAGATGTTCACTCGCATCTTCACCCCAAA
CTTCCCTGAATTGCAGTGATTTCTGTTATAAGGCACATAGCAAGCCTGTACCACTCTACAGTAAAATCTCTACACTAACAGTTTAAAGCC
CGAAAGCTGAAGCATTCAGCCTCTGCAAGTGTAGACTACTGGACTGTAGTAGAGGCATTTGGAATACTTACAAAGTCAAGTGCTGTGGCT
TCAGTTCCCCCGGCTCCCCACCCCTGACATCCATACTTATGTTGTCTGGAAGAGCCATGGACACATCATTATTTTCAGCAACCAGCTGCA
GTGAAACTCCATTTACAGCAACCCCATAGTATAAAACCACAATGCCTCATTGTAATGGGATATTGAAGTTCATTGAAGAATTACTAGGTT
GCCATGTGGCTCACTTATTTAAAAAAAAAAAAAAAAAACTCACCCGTTTTCCTGGGATTTGTTGTAAGGAGTTTTCACTGGCCTCACTCA
GACCAATTTCTGCTTCAAAAAGCACTGAATGTGACCTGTTGCATTCAGTTGTAGCATCAAATCCACACCTAGTCATTGCTTGAGGGGCCA
AATTGTGTTCTGTCCCATGCACGCTCTATTTGGTGTTAAAATGGAACCTTACGGTTGTGTTTTAAGTATTCATTGAAACCAGCTTCAGAA
AACAAGATGCCATAGTAAATTGAGAATAACATTTTTTCCTTCTTCAGGGTGGCTGTAATTCCAGGTGGCCGTGATTTCTTTCTTCCCCAC
TGCCCACTCCTTCGCCAAACCCACGTATTCAGTGTTCTGATCTTGTTTGTGCAGAGTGAACTCTGATGCAGTATCAGTCTTGTCCTGGGA
GCCGGGTCCTGCTGCTCACAAGCCCAGAGCTGCCAGGGAGCTCCTGGCAGTAGCACGTTGTTTAGAAAGTTGGGTGGCTTCATTCAGCAT
GGAACAAGCTAATGGCACAGGAGACATCAGGGCAGCTGTTAATTCCAAATATTTGTTCCCAAGTAGCTACTGAACTGCTCACACCATTGG
AAGATTTTGTATTTTCATACCAATTAGTAAAAATAAGAACATTGAGGAGCAGTCAGAGCCCAGTGTTAATCTCCGGCAGAGATGGGGTTT
ATGTATGTTCAGCCAGATAGTAAATGGGATTTTTGGAGAAATAAGATAACTACAAAGTTTCTATACTTACTATAAGTGGATTTAGAAGCG
ATTTTGGTTTTGTATTACATACGGTAGTCCTCTGCGTCAGGGAGCACTTTTTTGTTTGCCTCGAGACTACTCATTAGCGCACTGGCTAAG
CTGCCTTTGCCTTCTCGTAGGCGTGGGTTGCCTGTGTCATGGGCTGTGTAGACCACAACACTCAAACACAGTTGCTGCACTTGGATTTTC
CTTTAATACCAAGTATCATTTGGTTATCTTACTGGGACATTTTCATTGATATTCTATACACCAAAGTTTTGACGGTTTACCATCATTCCA
TTTTGTACCAGTTAAAGGCATTTTGATGATGCTTTTTCTTGATGCTAAGATCACTGCAGAAGAATAACCTGACCTTTTCTTTGCATTTGT
TTTGAATGTCTAACACCATTAGCTTTTGTGATCTGGTTAAGAAGTATTAGTGCCACAAGCCTGAAAAGACAGTTCTCCTGTGGCAGTGGC
GATGTGGCATCCAGAGGGCCATTGTTTCTACTTTTGTGGGACTTCAGTCATGCTGATAATAGAATCTTCTGTTCATACAATTCTGTAATA
TTTATTTGTACAGTTAGTATTCTAATGAAAGGATGAAGAGTCTGAACTAGAAGGTAGGTTTAAGCCATCACCAGGCCTTTGCAAATGGCC
TAAATGGTGTTCCCTTTGAAATAACGCTTGCCACAAGTATATAATAAGCTATATTAATTGTGTTTTGCATAAAATTGCCAAAACACAGTA
ATGTGTATATAGTGGTATAAGATCTTGAAAAAAATCTCTATAATTGTGCTCTTTATCTGTGAATGGGAAAAGCCATTTTTAGTAGGTGAC
TACCATTTGAAAAACTCAATTGGATGTATATCTGAATGTTGCATTGTATTGTACAGTATGCATATTATTGTTTGTGGTTGCATATGGCAA

>51523_51523_8_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000398822_ARHGEF7_chr13_111806252_ENST00000375741_length(amino acids)=855AA_BP=49
MAGRQAIGPSGCRLFSSPARRLPSSSRSASAAAPAAAQSLREGRQELSGGRRASSSARRRRRRPGSQHGGGGGGGRGPGDGPRAGVRRGA
ALHQPLVHRRGRLRHGVVYPEPRSESECLSNIREFLRGCGASLRLELLFPPSQPPQHLVTTILLSASTFDANDLYQGQNFNKVLSSLVTL
NKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEE
GGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS
SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILV
LTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLI
QCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTK
VTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALC
YKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGR

--------------------------------------------------------------
>51523_51523_9_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000398822_ARHGEF7_chr13_111870026_ENST00000317133_length(transcript)=3344nt_BP=359nt
GCCCCTCCCTCCGCCCGCCCGCCGGCCCGCCCGTCAGTCTGGCAGGCAGGCAGGCAATCGGTCCGAGTGGCTGTCGGCTCTTCAGCTCTC
CCGCTCGGCGTCTTCCTTCCTCCTCCCGGTCAGCGTCGGCGGCTGCACCGGCGGCGGCGCAGTCCCTGCGGGAGGGGCGACAAGAGCTGA
GCGGCGGCCGCCGAGCGTCGAGCTCAGCGCGGCGGAGGCGGCGGCGGCCCGGCAGCCAACATGGCGGCGGCGGCGGCGGCGGGCGCGGGC
CCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAACCTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGG
ACATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGTTTAACTTCCAGCAGACCAATGAGGACGAGCTTTCCTTCTCAAAAG
GAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCACACTCAACGGCCGGACCGGCTGGTTCCCCAGCAACTACG
TGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTGTCTCCCAAATCAGGAACACTGAAGAGCCCTCCCAAAGGATTTGATACGACTGCCATAA
ACAAAAGCTATTACAATGTGGTGCTACAGAATATTTTAGAAACAGAAAATGAATATTCTAAAGAACTTCAGACTGTGCTTTCAACGTACC
TACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAATGGGAAATCTAGAAGAAATATGTTCTTTCCAGCAAA
TGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGAGAGTCGGAGGCTGCTTTTTAAACCTGATGCCACAGATGA
AAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCCTCACGGAACACAGTGAGGAGTTGGGGGAGTTCATGGAGA
CCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAACCCTTCATGCGCCTGGATAAATACCCTACGCTGCTCA
AAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTCAAAAATCCATGGCTGCCTTCAAAAACCTTTCAGCCCAAT
GTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAGCCATCCGGAACTGGGAGGGCGATGACATTAAAACTCTGG
GCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAAAGAATGAAAGATATCTTCTACTCTTCCCAAATGTTT
TGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGCTTCCAACGACAGGAATGACAATCACAAAGCTTGAGG
ACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGCGGATATTAGTGTCGTGCAACAACCAGCAGGATCTGCAGG
AATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACCCCACCATAAAGCCTCATTCAGTGCCATCTCATACCCTCC
CCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGCTGACGCCCGCCTACCACACGCTGCCCCACCCCTCCC
ACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGAAAACACCCAAGCCCTGGAGCCTGAGCTGCCTGCGGCCCG
CGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTAAGAGCCCTAAGACCATGAAAAAGCTGCTGCCCAAGCGCA
AACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTGCTTTGGAAGAAGATGCTCAGATTCTGAAAGTCATTG
AAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAACATGGCAAGGCACTGACCTGATGCATAATCACGTCTTGGCTGATG
ATGACCAACCAAGCCTAGACTCCCTGGGGCGTCGCAGTAGCCTTTCTCGTTTGGAGCCTTCAGACCTCTCGGAAGACTCTGACTATGACA
GTATATGGACAGCCCATAGTTACAGAATGGGTTCTACATCTCGTAAGAGCTGTTGCTCATATATCTCTCACCAGAACTAATGCACTTCTG
AGCTTTTCTTAACAAATGCTTGTTGTATCGCAGCCTGCTTTTCTTAGATGTTTTCTTGCTGTTCCTTGTCTCTTTTATGTGATATTTTAA
CAACTTTTGAGAGTGTTCCTGATATTTCCCATTGTACTTTGTGGAGGCTTAACTGCCGATGCGAGTATACATTCGAATGACTGACTATTG
GAGGGAGGTGGTGTGTTCACGTGAGCCTACATCCGAGGGTGCTCTTCGTAAGGGGTAGTTGTTGTTTTATAGCTCCAAATGGTTTTTTTA
TTCTCAGTGTAGCAACTGTTTGATTTCTTTCTGGATACAGCTGTATGAACACTTTTCTATTTTATACTGAAATCACACAGGTTTGTGATC
TAAGTGCCAGAACCATGGAGGAGACTCTGGCCTTATCTGTAGGGACCTAAATTTTTTAAGTGCTATGAACACTGATCAAGTAGTTGTGGA
GAGATGAGAAGAATATATGCAGCAAAGGTGCTGTGAGCCCAGTTCCAACGGCTGTGTTCTGGTAATCGTGCAGAACAGCATGTGGGCTCT
GGGCCTTGGCAGGTGCACAGACGGGCGGGCGTCACGTGTGTTCAGAGCTTGTCTCCACCTCACGGCTCTGTGCTCTTCTGTGTGCTGCGT
TGTGGCCGTGAAGTGGGAGCTCTCCTTTCCAAAGGCAGAGCTTACTGTCATGGCTCAGATGTTCACTCGCATCTTCACCCCAAACTTCCC
TGAATTGCAGTGATTTCTGTTATAAGGCACATAGCAAGCCTGTACCACTCTACAGTAAAATCTCTACACTAACAGTTTAAAGCCCGAAAG
CTGAAGCATTCAGCCTCTGCAAGTGTAGACTACTGGACTGTAGTAGAGGCATTTGGAATACTTACAAAGTCAAGTGCTGTGGCTTCAGTT
CCCCCGGCTCCCCACCCCTGACATCCATACTTATGTTGTCTGGAAGAGCCATGGACACATCATTATTTTCAGCAACCAGCTGCAGTGAAA
CTCCATTTACAGCAACCCCATAGTATAAAACCACAATGCCTCATTGTAATGGGATATTGAAGTTCATTGAAGAATTACTAGGTTGCCATG

>51523_51523_9_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000398822_ARHGEF7_chr13_111870026_ENST00000317133_length(amino acids)=733AA_BP=49
MAGRQAIGPSGCRLFSSPARRLPSSSRSASAAAPAAAQSLREGRQELSGGRRASSSARRRRRRPGSQHGGGGGGGRGPGDGPRAGVRRGA
ALHQPLVHRRGRLRHGVDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP
KSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLP
EAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTD
RQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGF
IYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHAD
SKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFAS
RKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGST

--------------------------------------------------------------
>51523_51523_10_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000398822_ARHGEF7_chr13_111870026_ENST00000370623_length(transcript)=4921nt_BP=359nt
GCCCCTCCCTCCGCCCGCCCGCCGGCCCGCCCGTCAGTCTGGCAGGCAGGCAGGCAATCGGTCCGAGTGGCTGTCGGCTCTTCAGCTCTC
CCGCTCGGCGTCTTCCTTCCTCCTCCCGGTCAGCGTCGGCGGCTGCACCGGCGGCGGCGCAGTCCCTGCGGGAGGGGCGACAAGAGCTGA
GCGGCGGCCGCCGAGCGTCGAGCTCAGCGCGGCGGAGGCGGCGGCGGCCCGGCAGCCAACATGGCGGCGGCGGCGGCGGCGGGCGCGGGC
CCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAACCTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGG
ACATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGTTTAACTTCCAGCAGACCAATGAGGACGAGCTTTCCTTCTCAAAAG
GAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCACACTCAACGGCCGGACCGGCTGGTTCCCCAGCAACTACG
TGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTGTCTCCCAAATCAGGAACACTGAAGAGCCCTCCCAAAGGATTTGATACGACTGCCATAA
ACAAAAGCTATTACAATGTGGTGCTACAGAATATTTTAGAAACAGAAAATGAATATTCTAAAGAACTTCAGACTGTGCTTTCAACGTACC
TACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAATGGGAAATCTAGAAGAAATATGTTCTTTCCAGCAAA
TGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGAGAGTCGGAGGCTGCTTTTTAAACCTGATGCCACAGATGA
AAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCCTCACGGAACACAGTGAGGAGTTGGGGGAGTTCATGGAGA
CCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAACCCTTCATGCGCCTGGATAAATACCCTACGCTGCTCA
AAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTCAAAAATCCATGGCTGCCTTCAAAAACCTTTCAGCCCAAT
GTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAGCCATCCGGAACTGGGAGGGCGATGACATTAAAACTCTGG
GCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAAAGAATGAAAGATATCTTCTACTCTTCCCAAATGTTT
TGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGCTTCCAACGACAGGAATGACAATCACAAAGCTTGAGG
ACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGCGGATATTAGTGTCGTGCAACAACCAGCAGGATCTGCAGG
AATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACCCCACCATAAAGCCTCATTCAGTGCCATCTCATACCCTCC
CCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGCTGACGCCCGCCTACCACACGCTGCCCCACCCCTCCC
ACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGAAAACACCCAAGCCCTGGAGCCTGAGCTGCCTGCGGCCCG
CGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTAAGAGCCCTAAGACCATGAAAAAGCTGCTGCCCAAGCGCA
AACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTGCTTTGGAAGAAGATGCTCAGATTCTGAAAGTCATTG
AAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAAGTTCACGCAAAGAATCTGCTCCACAAGTTTTGCTTCCAGAAGAAG
AGAAAATTATAGTGGAAGAAACTAAAAGTAATGGTCAGACAGTGATAGAAGAAAAGAGTCTTGTGGATACCGTATATGCATTAAAGGATG
AAGTTCAAGAATTAAGACAGGACAACAAAAAGATGAAGAAATCTCTAGAGGAAGAACAGAGAGCCCGCAAAGACCTGGAGAAGCTGGTGA
GGAAAGTCCTGAAGAACATGAATGATCCTGCCTGGGATGAGACCAATCTATAAGGGATGTCCTCAGTTCTTTCTGTTGAAGACCAGTTCT
GAGGTGAAGCTGGGCACCCCTGACCCAAGTCGGGGTGCACTCAGGACCACAGGGCAGGGCTGGGTGGGGCGCCACCTTGCTCTCTGTATA
TAGAAAAGCTGGAGCTTATTCTGCGAATGGAGACGATCAAACCATGACTGATGAATCCAGACAGGAGGGATTGACTCTGAGGACCTGAGC
TACATCAATCCACTCTGTGAACATCTCAGTTACCTCATTCTGCAATAAGTTCAGTGACTGACTAAAAGTCTTGTTTTTCCAGACTTTGAA
TTGAATATATAAATATTATATATACATGTTTCTTGTAAATATCCCATTTTGAATGCATACCTGTGGTGGTTCTGTCCGGGCTAATCCCCA
TGCTAGAATGTCCTTTCCAGCTACGTGAATAAGAAGTCCCATGCCCGCATCCACCGGAAGCAGAAGCCTGGTGGATGCCTGGTTCGTTCC
GCAGCACCAGGGCCTCCACCGTGCTGTGGCAGCACCCCCCATGTCGGTATTTCTAAATAACCTTATTTATACCTGCAGAGATACACTTCA
GTCCCATTCAGAAGTCTTCTCTTAAAGCAGCATTACAGTCCCAGACCTGCGGGTTTCTGAGGGCAACTTGCTGGCTGACAGACTCAGTCT
TGACCTCAAGGAAGGCCCATACGGCACTGCCGCATCCACCTAGAGGTGTTTGCTCTTGTCCGCTGTCTGAGTACTGTGATTCTCAGATGA
GTTTGCTGCGTTTTGGGAGGACACAGACGGTTCTGTATAGGCTAGTTCAGTAACAACAAAATACACTGTTTTGTCTTCCCTCAAAGAGAG
ATCTTACTAGAACCTGTAAATAGAATGTATTATTTATTATAAGTCACTGCAGCTGATGAAAACAGATGGAGGCCATGCTGCAGGCTGATA
CTGATGGGTGGAGTTTTGTCATCAGGCCAGCCTCATCCCGAGGTCTCCTCCACCATTGGCCGTAGCCAGCAGGCTTCAGTGCTCACCGAA
AGTAAAATCCCCTCCTTCAGCAAGAATAAAGCAATATACACCTTAGGTTCCACTAAGTAACATAGGCATAAGCAGGGAACGTTTCCCCCA
CTGTGTTCCAGTGCAGAGGAGACGAAGCCTGTCCTCACCGCGGCTCGCTGGGCCCAGGCTGGCTCTGGAAAGCCTGTGCGGTCCTGGGCA
GGAAGCCCGGCCCGTGGAGCAGGTTTTCGTTCTGCTTCAGCAATAAATAAGGGTGACCACAGGGACTTTGCTTTTGGTTTCCTTTCCTGT
GAAAAGGTTGGTTTTAAAGTGAGATACACTTTTCCGTAGAACAAGTGTTCTATCTTTAAAAACCCAAATTGCAGCACCGTGGATTACTGG
TCTCAGAACAACTCATTGCGCATCAGATTTGACTCTCTGATTTTCTGTCTATTGGCCAAATTGCCCTTTAACTGCACCTGAATCCTTTGT
GTACTGATGCCTTTGAGCTGGGCACCTTGGGAGAGTGTTGTGTTGCTGTTTACGGTTCTTCCTTGCCCTTGCTAATTACAGTCTCTGGTG
CCCAGCAAGCCCCTTTGGCTTCCTTCCGTGACTGGTCACGTTGTCTGCCTGGGCTCAGCGTGGACCTGCCCCATGCTGCAGAACCTGGCC
TCACCTGGACTTTTCACTAGAATTGCCAGCTTCCTCAACTTAGCAGATCATTCACTCATGCGGGCACAAGCAAAGATCAACACTTTCTTT
TTTGGTAAGCTTGAGTTTTACAAGTTATTTTTTGGTGATGCGTAAGACATTGCAGTGGGAAACCATTCAACTTGAGTTTATTGGAGTTTG
CTGTTGTAGCAGGTTTTAACTCAGGAACAACTCTTGTCTGATCTCTCCGCCCCTCTGCCGGGAGGCGACATTAACTGTCCTCTCGGAGCC
GGTAGCGTTGCTGTCCGAGTCCCCAGGACGGATCTCCTGCAGACCTGCCTTAATGCTCAGATCGAAGTATTTCACAAGAATACTTGTGTT
TTTAACAGCCCTTCCCCTGGACGGTGCGGCCATGAGGGCCTCATGTTACGGCATTGCCTTTTCTTTCTGTGGATCCAGTATCTTCCTCGG
CTTTTTAGGGAGCAGGAAAAATGCGTCTGAGAGCAACTCTTTTTAAAAACCTGCCCTGTTGTATATAACTGTGTCTGTTTCACCGTGTGA
CCTCCCAAGGGGGTGGGAACTTGATATAAACGTTTAAAGGGGCCACGATTTGCCCGAGGGTTACTCCTTTGCTCTCACCTTGTATGGATG
AGGAGATGAAGCCATTTCTTATCCTGTAGATGTGAAGCACTTTCAGTTTTCAGCGATGTTGGAATGTAGCATCAGAAGCTCGTTCCTTCA
CACTCAGTGGCGTCTGTGCTTGTCCACATGCGCTGGGCGTCTGGGACCTTGAATGCCTGCCCTGGTTGTGTGGACTCCTTAATGCCAATC
ATTTCTTCACTTCTCTGGGACACCCAGGGCGCCTGTTGACAAGTGTGGAGAAACTCCTAATTTAAATGTCACAGACAATGTCCTAGTGTT

>51523_51523_10_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000398822_ARHGEF7_chr13_111870026_ENST00000370623_length(amino acids)=754AA_BP=49
MAGRQAIGPSGCRLFSSPARRLPSSSRSASAAAPAAAQSLREGRQELSGGRRASSSARRRRRRPGSQHGGGGGGGRGPGDGPRAGVRRGA
ALHQPLVHRRGRLRHGVDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP
KSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLP
EAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTD
RQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGF
IYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHAD
SKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFAS
RKSTAALEEDAQILKVIEAYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMK

--------------------------------------------------------------
>51523_51523_11_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000398822_ARHGEF7_chr13_111870026_ENST00000375739_length(transcript)=5103nt_BP=359nt
GCCCCTCCCTCCGCCCGCCCGCCGGCCCGCCCGTCAGTCTGGCAGGCAGGCAGGCAATCGGTCCGAGTGGCTGTCGGCTCTTCAGCTCTC
CCGCTCGGCGTCTTCCTTCCTCCTCCCGGTCAGCGTCGGCGGCTGCACCGGCGGCGGCGCAGTCCCTGCGGGAGGGGCGACAAGAGCTGA
GCGGCGGCCGCCGAGCGTCGAGCTCAGCGCGGCGGAGGCGGCGGCGGCCCGGCAGCCAACATGGCGGCGGCGGCGGCGGCGGGCGCGGGC
CCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAACCTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGG
ACATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGTTTAACTTCCAGCAGACCAATGAGGACGAGCTTTCCTTCTCAAAAG
GAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCACACTCAACGGCCGGACCGGCTGGTTCCCCAGCAACTACG
TGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTGTCTCCCAAATCAGGAACACTGAAGAGCCCTCCCAAAGGATTTGATACGACTGCCATAA
ACAAAAGCTATTACAATGTGGTGCTACAGAATATTTTAGAAACAGAAAATGAATATTCTAAAGAACTTCAGACTGTGCTTTCAACGTACC
TACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAATGGGAAATCTAGAAGAAATATGTTCTTTCCAGCAAA
TGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGAGAGTCGGAGGCTGCTTTTTAAACCTGATGCCACAGATGA
AAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCCTCACGGAACACAGTGAGGAGTTGGGGGAGTTCATGGAGA
CCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAACCCTTCATGCGCCTGGATAAATACCCTACGCTGCTCA
AAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTCAAAAATCCATGGCTGCCTTCAAAAACCTTTCAGCCCAAT
GTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAGCCATCCGGAACTGGGAGGGCGATGACATTAAAACTCTGG
GCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAAAGAATGAAAGATATCTTCTACTCTTCCCAAATGTTT
TGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGCTTCCAACGACAGGAATGACAATCACAAAGCTTGAGG
ACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGCGGATATTAGTGTCGTGCAACAACCAGCAGGATCTGCAGG
AATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACCCCACCATAAAGCCTCATTCAGTGCCATCTCATACCCTCC
CCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGCTGACGCCCGCCTACCACACGCTGCCCCACCCCTCCC
ACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGAAAACACCCAAGCCCTGGAGCCTGAGCTGCCTGCGGCCCG
CGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTAAGAGCCCTAAGACCATGAAAAAGCTGCTGCCCAAGCGCA
AACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTGCTTTGGAAGAAGATGCTCAGATTCTGAAAGTCATTG
AAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAACATGGCAAGGCACTGACCTGATGCATAATCACGTCTTGGCTGATG
ATGACCAACCAAGCCTAGACTCCCTGGGGCGTCGCAGTAGCCTTTCTCGTTTGGAGCCTTCAGACCTCTCGGAAGACTCTGACTATGACA
GTATATGGACAGCCCATAGTTACAGAATGGGTTCTACATCTCGTAAGAGCTGTTGCTCATATATCTCTCACCAGAACTAATGCACTTCTG
AGCTTTTCTTAACAAATGCTTGTTGTATCGCAGCCTGCTTTTCTTAGATGTTTTCTTGCTGTTCCTTGTCTCTTTTATGTGATATTTTAA
CAACTTTTGAGAGTGTTCCTGATATTTCCCATTGTACTTTGTGGAGGCTTAACTGCCGATGCGAGTATACATTCGAATGACTGACTATTG
GAGGGAGGTGGTGTGTTCACGTGAGCCTACATCCGAGGGTGCTCTTCGTAAGGGGTAGTTGTTGTTTTATAGCTCCAAATGGTTTTTTTA
TTCTCAGTGTAGCAACTGTTTGATTTCTTTCTGGATACAGCTGTATGAACACTTTTCTATTTTATACTGAAATCACACAGGTTTGTGATC
TAAGTGCCAGAACCATGGAGGAGACTCTGGCCTTATCTGTAGGGACCTAAATTTTTTAAGTGCTATGAACACTGATCAAGTAGTTGTGGA
GAGATGAGAAGAATATATGCAGCAAAGGTGCTGTGAGCCCAGTTCCAACGGCTGTGTTCTGGTAATCGTGCAGAACAGCATGTGGGCTCT
GGGCCTTGGCAGGTGCACAGACGGGCGGGCGTCACGTGTGTTCAGAGCTTGTCTCCACCTCACGGCTCTGTGCTCTTCTGTGTGCTGCGT
TGTGGCCGTGAAGTGGGAGCTCTCCTTTCCAAAGGCAGAGCTTACTGTCATGGCTCAGATGTTCACTCGCATCTTCACCCCAAACTTCCC
TGAATTGCAGTGATTTCTGTTATAAGGCACATAGCAAGCCTGTACCACTCTACAGTAAAATCTCTACACTAACAGTTTAAAGCCCGAAAG
CTGAAGCATTCAGCCTCTGCAAGTGTAGACTACTGGACTGTAGTAGAGGCATTTGGAATACTTACAAAGTCAAGTGCTGTGGCTTCAGTT
CCCCCGGCTCCCCACCCCTGACATCCATACTTATGTTGTCTGGAAGAGCCATGGACACATCATTATTTTCAGCAACCAGCTGCAGTGAAA
CTCCATTTACAGCAACCCCATAGTATAAAACCACAATGCCTCATTGTAATGGGATATTGAAGTTCATTGAAGAATTACTAGGTTGCCATG
TGGCTCACTTATTTAAAAAAAAAAAAAAAAAACTCACCCGTTTTCCTGGGATTTGTTGTAAGGAGTTTTCACTGGCCTCACTCAGACCAA
TTTCTGCTTCAAAAAGCACTGAATGTGACCTGTTGCATTCAGTTGTAGCATCAAATCCACACCTAGTCATTGCTTGAGGGGCCAAATTGT
GTTCTGTCCCATGCACGCTCTATTTGGTGTTAAAATGGAACCTTACGGTTGTGTTTTAAGTATTCATTGAAACCAGCTTCAGAAAACAAG
ATGCCATAGTAAATTGAGAATAACATTTTTTCCTTCTTCAGGGTGGCTGTAATTCCAGGTGGCCGTGATTTCTTTCTTCCCCACTGCCCA
CTCCTTCGCCAAACCCACGTATTCAGTGTTCTGATCTTGTTTGTGCAGAGTGAACTCTGATGCAGTATCAGTCTTGTCCTGGGAGCCGGG
TCCTGCTGCTCACAAGCCCAGAGCTGCCAGGGAGCTCCTGGCAGTAGCACGTTGTTTAGAAAGTTGGGTGGCTTCATTCAGCATGGAACA
AGCTAATGGCACAGGAGACATCAGGGCAGCTGTTAATTCCAAATATTTGTTCCCAAGTAGCTACTGAACTGCTCACACCATTGGAAGATT
TTGTATTTTCATACCAATTAGTAAAAATAAGAACATTGAGGAGCAGTCAGAGCCCAGTGTTAATCTCCGGCAGAGATGGGGTTTATGTAT
GTTCAGCCAGATAGTAAATGGGATTTTTGGAGAAATAAGATAACTACAAAGTTTCTATACTTACTATAAGTGGATTTAGAAGCGATTTTG
GTTTTGTATTACATACGGTAGTCCTCTGCGTCAGGGAGCACTTTTTTGTTTGCCTCGAGACTACTCATTAGCGCACTGGCTAAGCTGCCT
TTGCCTTCTCGTAGGCGTGGGTTGCCTGTGTCATGGGCTGTGTAGACCACAACACTCAAACACAGTTGCTGCACTTGGATTTTCCTTTAA
TACCAAGTATCATTTGGTTATCTTACTGGGACATTTTCATTGATATTCTATACACCAAAGTTTTGACGGTTTACCATCATTCCATTTTGT
ACCAGTTAAAGGCATTTTGATGATGCTTTTTCTTGATGCTAAGATCACTGCAGAAGAATAACCTGACCTTTTCTTTGCATTTGTTTTGAA
TGTCTAACACCATTAGCTTTTGTGATCTGGTTAAGAAGTATTAGTGCCACAAGCCTGAAAAGACAGTTCTCCTGTGGCAGTGGCGATGTG
GCATCCAGAGGGCCATTGTTTCTACTTTTGTGGGACTTCAGTCATGCTGATAATAGAATCTTCTGTTCATACAATTCTGTAATATTTATT
TGTACAGTTAGTATTCTAATGAAAGGATGAAGAGTCTGAACTAGAAGGTAGGTTTAAGCCATCACCAGGCCTTTGCAAATGGCCTAAATG
GTGTTCCCTTTGAAATAACGCTTGCCACAAGTATATAATAAGCTATATTAATTGTGTTTTGCATAAAATTGCCAAAACACAGTAATGTGT
ATATAGTGGTATAAGATCTTGAAAAAAATCTCTATAATTGTGCTCTTTATCTGTGAATGGGAAAAGCCATTTTTAGTAGGTGACTACCAT
TTGAAAAACTCAATTGGATGTATATCTGAATGTTGCATTGTATTGTACAGTATGCATATTATTGTTTGTGGTTGCATATGGCAATGAAGT

>51523_51523_11_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000398822_ARHGEF7_chr13_111870026_ENST00000375739_length(amino acids)=733AA_BP=49
MAGRQAIGPSGCRLFSSPARRLPSSSRSASAAAPAAAQSLREGRQELSGGRRASSSARRRRRRPGSQHGGGGGGGRGPGDGPRAGVRRGA
ALHQPLVHRRGRLRHGVDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP
KSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLP
EAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTD
RQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGF
IYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHAD
SKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFAS
RKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGST

--------------------------------------------------------------
>51523_51523_12_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000398822_ARHGEF7_chr13_111870026_ENST00000375741_length(transcript)=5103nt_BP=359nt
GCCCCTCCCTCCGCCCGCCCGCCGGCCCGCCCGTCAGTCTGGCAGGCAGGCAGGCAATCGGTCCGAGTGGCTGTCGGCTCTTCAGCTCTC
CCGCTCGGCGTCTTCCTTCCTCCTCCCGGTCAGCGTCGGCGGCTGCACCGGCGGCGGCGCAGTCCCTGCGGGAGGGGCGACAAGAGCTGA
GCGGCGGCCGCCGAGCGTCGAGCTCAGCGCGGCGGAGGCGGCGGCGGCCCGGCAGCCAACATGGCGGCGGCGGCGGCGGCGGGCGCGGGC
CCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAACCTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGG
ACATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGTTTAACTTCCAGCAGACCAATGAGGACGAGCTTTCCTTCTCAAAAG
GAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCACACTCAACGGCCGGACCGGCTGGTTCCCCAGCAACTACG
TGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTGTCTCCCAAATCAGGAACACTGAAGAGCCCTCCCAAAGGATTTGATACGACTGCCATAA
ACAAAAGCTATTACAATGTGGTGCTACAGAATATTTTAGAAACAGAAAATGAATATTCTAAAGAACTTCAGACTGTGCTTTCAACGTACC
TACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAATGGGAAATCTAGAAGAAATATGTTCTTTCCAGCAAA
TGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGAGAGTCGGAGGCTGCTTTTTAAACCTGATGCCACAGATGA
AAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCCTCACGGAACACAGTGAGGAGTTGGGGGAGTTCATGGAGA
CCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAACCCTTCATGCGCCTGGATAAATACCCTACGCTGCTCA
AAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTCAAAAATCCATGGCTGCCTTCAAAAACCTTTCAGCCCAAT
GTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAGCCATCCGGAACTGGGAGGGCGATGACATTAAAACTCTGG
GCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAAAGAATGAAAGATATCTTCTACTCTTCCCAAATGTTT
TGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGCTTCCAACGACAGGAATGACAATCACAAAGCTTGAGG
ACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGCGGATATTAGTGTCGTGCAACAACCAGCAGGATCTGCAGG
AATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACCCCACCATAAAGCCTCATTCAGTGCCATCTCATACCCTCC
CCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGCTGACGCCCGCCTACCACACGCTGCCCCACCCCTCCC
ACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGAAAACACCCAAGCCCTGGAGCCTGAGCTGCCTGCGGCCCG
CGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTAAGAGCCCTAAGACCATGAAAAAGCTGCTGCCCAAGCGCA
AACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTGCTTTGGAAGAAGATGCTCAGATTCTGAAAGTCATTG
AAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAACATGGCAAGGCACTGACCTGATGCATAATCACGTCTTGGCTGATG
ATGACCAACCAAGCCTAGACTCCCTGGGGCGTCGCAGTAGCCTTTCTCGTTTGGAGCCTTCAGACCTCTCGGAAGACTCTGACTATGACA
GTATATGGACAGCCCATAGTTACAGAATGGGTTCTACATCTCGTAAGAGCTGTTGCTCATATATCTCTCACCAGAACTAATGCACTTCTG
AGCTTTTCTTAACAAATGCTTGTTGTATCGCAGCCTGCTTTTCTTAGATGTTTTCTTGCTGTTCCTTGTCTCTTTTATGTGATATTTTAA
CAACTTTTGAGAGTGTTCCTGATATTTCCCATTGTACTTTGTGGAGGCTTAACTGCCGATGCGAGTATACATTCGAATGACTGACTATTG
GAGGGAGGTGGTGTGTTCACGTGAGCCTACATCCGAGGGTGCTCTTCGTAAGGGGTAGTTGTTGTTTTATAGCTCCAAATGGTTTTTTTA
TTCTCAGTGTAGCAACTGTTTGATTTCTTTCTGGATACAGCTGTATGAACACTTTTCTATTTTATACTGAAATCACACAGGTTTGTGATC
TAAGTGCCAGAACCATGGAGGAGACTCTGGCCTTATCTGTAGGGACCTAAATTTTTTAAGTGCTATGAACACTGATCAAGTAGTTGTGGA
GAGATGAGAAGAATATATGCAGCAAAGGTGCTGTGAGCCCAGTTCCAACGGCTGTGTTCTGGTAATCGTGCAGAACAGCATGTGGGCTCT
GGGCCTTGGCAGGTGCACAGACGGGCGGGCGTCACGTGTGTTCAGAGCTTGTCTCCACCTCACGGCTCTGTGCTCTTCTGTGTGCTGCGT
TGTGGCCGTGAAGTGGGAGCTCTCCTTTCCAAAGGCAGAGCTTACTGTCATGGCTCAGATGTTCACTCGCATCTTCACCCCAAACTTCCC
TGAATTGCAGTGATTTCTGTTATAAGGCACATAGCAAGCCTGTACCACTCTACAGTAAAATCTCTACACTAACAGTTTAAAGCCCGAAAG
CTGAAGCATTCAGCCTCTGCAAGTGTAGACTACTGGACTGTAGTAGAGGCATTTGGAATACTTACAAAGTCAAGTGCTGTGGCTTCAGTT
CCCCCGGCTCCCCACCCCTGACATCCATACTTATGTTGTCTGGAAGAGCCATGGACACATCATTATTTTCAGCAACCAGCTGCAGTGAAA
CTCCATTTACAGCAACCCCATAGTATAAAACCACAATGCCTCATTGTAATGGGATATTGAAGTTCATTGAAGAATTACTAGGTTGCCATG
TGGCTCACTTATTTAAAAAAAAAAAAAAAAAACTCACCCGTTTTCCTGGGATTTGTTGTAAGGAGTTTTCACTGGCCTCACTCAGACCAA
TTTCTGCTTCAAAAAGCACTGAATGTGACCTGTTGCATTCAGTTGTAGCATCAAATCCACACCTAGTCATTGCTTGAGGGGCCAAATTGT
GTTCTGTCCCATGCACGCTCTATTTGGTGTTAAAATGGAACCTTACGGTTGTGTTTTAAGTATTCATTGAAACCAGCTTCAGAAAACAAG
ATGCCATAGTAAATTGAGAATAACATTTTTTCCTTCTTCAGGGTGGCTGTAATTCCAGGTGGCCGTGATTTCTTTCTTCCCCACTGCCCA
CTCCTTCGCCAAACCCACGTATTCAGTGTTCTGATCTTGTTTGTGCAGAGTGAACTCTGATGCAGTATCAGTCTTGTCCTGGGAGCCGGG
TCCTGCTGCTCACAAGCCCAGAGCTGCCAGGGAGCTCCTGGCAGTAGCACGTTGTTTAGAAAGTTGGGTGGCTTCATTCAGCATGGAACA
AGCTAATGGCACAGGAGACATCAGGGCAGCTGTTAATTCCAAATATTTGTTCCCAAGTAGCTACTGAACTGCTCACACCATTGGAAGATT
TTGTATTTTCATACCAATTAGTAAAAATAAGAACATTGAGGAGCAGTCAGAGCCCAGTGTTAATCTCCGGCAGAGATGGGGTTTATGTAT
GTTCAGCCAGATAGTAAATGGGATTTTTGGAGAAATAAGATAACTACAAAGTTTCTATACTTACTATAAGTGGATTTAGAAGCGATTTTG
GTTTTGTATTACATACGGTAGTCCTCTGCGTCAGGGAGCACTTTTTTGTTTGCCTCGAGACTACTCATTAGCGCACTGGCTAAGCTGCCT
TTGCCTTCTCGTAGGCGTGGGTTGCCTGTGTCATGGGCTGTGTAGACCACAACACTCAAACACAGTTGCTGCACTTGGATTTTCCTTTAA
TACCAAGTATCATTTGGTTATCTTACTGGGACATTTTCATTGATATTCTATACACCAAAGTTTTGACGGTTTACCATCATTCCATTTTGT
ACCAGTTAAAGGCATTTTGATGATGCTTTTTCTTGATGCTAAGATCACTGCAGAAGAATAACCTGACCTTTTCTTTGCATTTGTTTTGAA
TGTCTAACACCATTAGCTTTTGTGATCTGGTTAAGAAGTATTAGTGCCACAAGCCTGAAAAGACAGTTCTCCTGTGGCAGTGGCGATGTG
GCATCCAGAGGGCCATTGTTTCTACTTTTGTGGGACTTCAGTCATGCTGATAATAGAATCTTCTGTTCATACAATTCTGTAATATTTATT
TGTACAGTTAGTATTCTAATGAAAGGATGAAGAGTCTGAACTAGAAGGTAGGTTTAAGCCATCACCAGGCCTTTGCAAATGGCCTAAATG
GTGTTCCCTTTGAAATAACGCTTGCCACAAGTATATAATAAGCTATATTAATTGTGTTTTGCATAAAATTGCCAAAACACAGTAATGTGT
ATATAGTGGTATAAGATCTTGAAAAAAATCTCTATAATTGTGCTCTTTATCTGTGAATGGGAAAAGCCATTTTTAGTAGGTGACTACCAT
TTGAAAAACTCAATTGGATGTATATCTGAATGTTGCATTGTATTGTACAGTATGCATATTATTGTTTGTGGTTGCATATGGCAATGAAGT

>51523_51523_12_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000398822_ARHGEF7_chr13_111870026_ENST00000375741_length(amino acids)=733AA_BP=49
MAGRQAIGPSGCRLFSSPARRLPSSSRSASAAAPAAAQSLREGRQELSGGRRASSSARRRRRRPGSQHGGGGGGGRGPGDGPRAGVRRGA
ALHQPLVHRRGRLRHGVDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP
KSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLP
EAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTD
RQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGF
IYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHAD
SKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFAS
RKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGST

--------------------------------------------------------------
>51523_51523_13_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000544786_ARHGEF7_chr13_111806252_ENST00000317133_length(transcript)=3407nt_BP=119nt
ATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAACCTCTCGTAC
ATCGGCGAGGGCGCCTACGGCATGGTGTGGTCTACCCCGAGCCCCGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGTTCCTGCGCG
GCTGCGGGGCTTCCCTGCGGCTGGAGACGTTTGATGCAAATGATTTGTATCAGGGGCAGAATTTTAACAAGGTCCTCAGTTCCTTAGTGA
CTCTAAATAAAGTAACAGCAGACATCGGGCTGGGGAGTGACTCCGTGTGTGCCCGGCCCTCGTCTCACCGCATAAAGTCTTTTGACTCCC
TTGGATCACAGTCTTTGCACACTCGGACTTCAAAACTGTTCCAGGGCCAGTATCGGAGTTTGGACATGACCGATAATAGCAACAATCAAC
TGGTAGTAAGAGCAAAGTTTAACTTCCAGCAGACCAATGAGGACGAGCTTTCCTTCTCAAAAGGAGACGTCATCCATGTCACCCGTGTGG
AAGAGGGAGGCTGGTGGGAGGGCACACTCAACGGCCGGACCGGCTGGTTCCCCAGCAACTACGTGCGCGAGGTCAAGGCCAGCGAGAAGC
CTGTGTCTCCCAAATCAGGAACACTGAAGAGCCCTCCCAAAGGATTTGATACGACTGCCATAAACAAAAGCTATTACAATGTGGTGCTAC
AGAATATTTTAGAAACAGAAAATGAATATTCTAAAGAACTTCAGACTGTGCTTTCAACGTACCTACGGCCATTGCAGACCAGTGAGAAGT
TAAGTTCAGCAAACATTTCATATTTAATGGGAAATCTAGAAGAAATATGTTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCA
CCAAGTTGCCCGAAGCTCAGCAGAGAGTCGGAGGCTGCTTTTTAAACCTGATGCCACAGATGAAAACCCTGTACCTCACGTATTGTGCCA
ATCACCCTTCTGCAGTGAATGTCCTCACGGAACACAGTGAGGAGTTGGGGGAGTTCATGGAGACCAAAGGTGCCAGCAGCCCTGGGATTC
TCGTGCTGACCACGGGCCTGAGCAAACCCTTCATGCGCCTGGATAAATACCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATT
ATCATACAGATAGACAAGATATTCAAAAATCCATGGCTGCCTTCAAAAACCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGC
TTGAGCTGCAGATCCTGACGGAAGCCATCCGGAACTGGGAGGGCGATGACATTAAAACTCTGGGCAACGTCACTTACATGTCCCAGGTCC
TGATTCAGTGTGCCGGAAGTGAGGAAAAGAATGAAAGATATCTTCTACTCTTCCCAAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGA
TGAGTGGCTTTATCTATCAGGGAAAGCTTCCAACGACAGGAATGACAATCACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTG
AAATATCAGGGAGCATGATTGAGCGGATATTAGTGTCGTGCAACAACCAGCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAAGCAAA
CGAAGGTCACGTCTGTGGGAAACCCCACCATAAAGCCTCATTCAGTGCCATCTCATACCCTCCCCTCCCACCCGGTCACTCCGTCCAGCA
AGCACGCAGACAGCAAGCCCGCGCCGCTGACGCCCGCCTACCACACGCTGCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCA
ACTGGGGACCCCTGGAGCCTCCGAAAACACCCAAGCCCTGGAGCCTGAGCTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTC
TCTGCTACAAGGAGGATCTTAGTAAGAGCCCTAAGACCATGAAAAAGCTGCTGCCCAAGCGCAAACCTGAACGGAAGCCTTCAGATGAGG
AGTTCGCGTCCCGGAAAAGCACAGCTGCTTTGGAAGAAGATGCTCAGATTCTGAAAGTCATTGAAGCTTACTGCACCAGCGCCAAAACAA
GGCAAACACTCAATTCAACATGGCAAGGCACTGACCTGATGCATAATCACGTCTTGGCTGATGATGACCAACCAAGCCTAGACTCCCTGG
GGCGTCGCAGTAGCCTTTCTCGTTTGGAGCCTTCAGACCTCTCGGAAGACTCTGACTATGACAGTATATGGACAGCCCATAGTTACAGAA
TGGGTTCTACATCTCGTAAGAGCTGTTGCTCATATATCTCTCACCAGAACTAATGCACTTCTGAGCTTTTCTTAACAAATGCTTGTTGTA
TCGCAGCCTGCTTTTCTTAGATGTTTTCTTGCTGTTCCTTGTCTCTTTTATGTGATATTTTAACAACTTTTGAGAGTGTTCCTGATATTT
CCCATTGTACTTTGTGGAGGCTTAACTGCCGATGCGAGTATACATTCGAATGACTGACTATTGGAGGGAGGTGGTGTGTTCACGTGAGCC
TACATCCGAGGGTGCTCTTCGTAAGGGGTAGTTGTTGTTTTATAGCTCCAAATGGTTTTTTTATTCTCAGTGTAGCAACTGTTTGATTTC
TTTCTGGATACAGCTGTATGAACACTTTTCTATTTTATACTGAAATCACACAGGTTTGTGATCTAAGTGCCAGAACCATGGAGGAGACTC
TGGCCTTATCTGTAGGGACCTAAATTTTTTAAGTGCTATGAACACTGATCAAGTAGTTGTGGAGAGATGAGAAGAATATATGCAGCAAAG
GTGCTGTGAGCCCAGTTCCAACGGCTGTGTTCTGGTAATCGTGCAGAACAGCATGTGGGCTCTGGGCCTTGGCAGGTGCACAGACGGGCG
GGCGTCACGTGTGTTCAGAGCTTGTCTCCACCTCACGGCTCTGTGCTCTTCTGTGTGCTGCGTTGTGGCCGTGAAGTGGGAGCTCTCCTT
TCCAAAGGCAGAGCTTACTGTCATGGCTCAGATGTTCACTCGCATCTTCACCCCAAACTTCCCTGAATTGCAGTGATTTCTGTTATAAGG
CACATAGCAAGCCTGTACCACTCTACAGTAAAATCTCTACACTAACAGTTTAAAGCCCGAAAGCTGAAGCATTCAGCCTCTGCAAGTGTA
GACTACTGGACTGTAGTAGAGGCATTTGGAATACTTACAAAGTCAAGTGCTGTGGCTTCAGTTCCCCCGGCTCCCCACCCCTGACATCCA
TACTTATGTTGTCTGGAAGAGCCATGGACACATCATTATTTTCAGCAACCAGCTGCAGTGAAACTCCATTTACAGCAACCCCATAGTATA

>51523_51523_13_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000544786_ARHGEF7_chr13_111806252_ENST00000317133_length(amino acids)=716AA_BP=
MSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSL
DMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAI
NKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQM
KTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQ
CQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLE
DSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPS
HHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVI

--------------------------------------------------------------
>51523_51523_14_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000544786_ARHGEF7_chr13_111806252_ENST00000375741_length(transcript)=5229nt_BP=119nt
ATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAACCTCTCGTAC
ATCGGCGAGGGCGCCTACGGCATGGTGTGGTCTACCCCGAGCCCCGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGTTCCTGCGCG
GCTGCGGGGCTTCCCTGCGGCTGGAGCTCCTGTTTCCTCCTTCCCAGCCTCCTCAGCATCTGGTAACCACCATTCTCTTGTCTGCTTCTA
CGTTTGATGCAAATGATTTGTATCAGGGGCAGAATTTTAACAAGGTCCTCAGTTCCTTAGTGACTCTAAATAAAGTAACAGCAGACATCG
GGCTGGGGAGTGACTCCGTGTGTGCCCGGCCCTCGTCTCACCGCATAAAGTCTTTTGACTCCCTTGGATCACAGTCTTTGCACACTCGGA
CTTCAAAACTGTTCCAGGGCCAGTATCGGAGTTTGGACATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGTTTAACTTCC
AGCAGACCAATGAGGACGAGCTTTCCTTCTCAAAAGGAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCACAC
TCAACGGCCGGACCGGCTGGTTCCCCAGCAACTACGTGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTGTCTCCCAAATCAGGAACACTGA
AGAGCCCTCCCAAAGGATTTGATACGACTGCCATAAACAAAAGCTATTACAATGTGGTGCTACAGAATATTTTAGAAACAGAAAATGAAT
ATTCTAAAGAACTTCAGACTGTGCTTTCAACGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAA
TGGGAAATCTAGAAGAAATATGTTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGAGAG
TCGGAGGCTGCTTTTTAAACCTGATGCCACAGATGAAAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCCTCA
CGGAACACAGTGAGGAGTTGGGGGAGTTCATGGAGACCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAAC
CCTTCATGCGCCTGGATAAATACCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTCAAA
AATCCATGGCTGCCTTCAAAAACCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAGCCA
TCCGGAACTGGGAGGGCGATGACATTAAAACTCTGGGCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAA
AGAATGAAAGATATCTTCTACTCTTCCCAAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGC
TTCCAACGACAGGAATGACAATCACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGCGGA
TATTAGTGTCGTGCAACAACCAGCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACCCCA
CCATAAAGCCTCATTCAGTGCCATCTCATACCCTCCCCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGC
TGACGCCCGCCTACCACACGCTGCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGAAAA
CACCCAAGCCCTGGAGCCTGAGCTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTAAGA
GCCCTAAGACCATGAAAAAGCTGCTGCCCAAGCGCAAACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTG
CTTTGGAAGAAGATGCTCAGATTCTGAAAGTCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAACATGGCAAG
GCACTGACCTGATGCATAATCACGTCTTGGCTGATGATGACCAACCAAGCCTAGACTCCCTGGGGCGTCGCAGTAGCCTTTCTCGTTTGG
AGCCTTCAGACCTCTCGGAAGACTCTGACTATGACAGTATATGGACAGCCCATAGTTACAGAATGGGTTCTACATCTCGTAAGAGCTGTT
GCTCATATATCTCTCACCAGAACTAATGCACTTCTGAGCTTTTCTTAACAAATGCTTGTTGTATCGCAGCCTGCTTTTCTTAGATGTTTT
CTTGCTGTTCCTTGTCTCTTTTATGTGATATTTTAACAACTTTTGAGAGTGTTCCTGATATTTCCCATTGTACTTTGTGGAGGCTTAACT
GCCGATGCGAGTATACATTCGAATGACTGACTATTGGAGGGAGGTGGTGTGTTCACGTGAGCCTACATCCGAGGGTGCTCTTCGTAAGGG
GTAGTTGTTGTTTTATAGCTCCAAATGGTTTTTTTATTCTCAGTGTAGCAACTGTTTGATTTCTTTCTGGATACAGCTGTATGAACACTT
TTCTATTTTATACTGAAATCACACAGGTTTGTGATCTAAGTGCCAGAACCATGGAGGAGACTCTGGCCTTATCTGTAGGGACCTAAATTT
TTTAAGTGCTATGAACACTGATCAAGTAGTTGTGGAGAGATGAGAAGAATATATGCAGCAAAGGTGCTGTGAGCCCAGTTCCAACGGCTG
TGTTCTGGTAATCGTGCAGAACAGCATGTGGGCTCTGGGCCTTGGCAGGTGCACAGACGGGCGGGCGTCACGTGTGTTCAGAGCTTGTCT
CCACCTCACGGCTCTGTGCTCTTCTGTGTGCTGCGTTGTGGCCGTGAAGTGGGAGCTCTCCTTTCCAAAGGCAGAGCTTACTGTCATGGC
TCAGATGTTCACTCGCATCTTCACCCCAAACTTCCCTGAATTGCAGTGATTTCTGTTATAAGGCACATAGCAAGCCTGTACCACTCTACA
GTAAAATCTCTACACTAACAGTTTAAAGCCCGAAAGCTGAAGCATTCAGCCTCTGCAAGTGTAGACTACTGGACTGTAGTAGAGGCATTT
GGAATACTTACAAAGTCAAGTGCTGTGGCTTCAGTTCCCCCGGCTCCCCACCCCTGACATCCATACTTATGTTGTCTGGAAGAGCCATGG
ACACATCATTATTTTCAGCAACCAGCTGCAGTGAAACTCCATTTACAGCAACCCCATAGTATAAAACCACAATGCCTCATTGTAATGGGA
TATTGAAGTTCATTGAAGAATTACTAGGTTGCCATGTGGCTCACTTATTTAAAAAAAAAAAAAAAAAACTCACCCGTTTTCCTGGGATTT
GTTGTAAGGAGTTTTCACTGGCCTCACTCAGACCAATTTCTGCTTCAAAAAGCACTGAATGTGACCTGTTGCATTCAGTTGTAGCATCAA
ATCCACACCTAGTCATTGCTTGAGGGGCCAAATTGTGTTCTGTCCCATGCACGCTCTATTTGGTGTTAAAATGGAACCTTACGGTTGTGT
TTTAAGTATTCATTGAAACCAGCTTCAGAAAACAAGATGCCATAGTAAATTGAGAATAACATTTTTTCCTTCTTCAGGGTGGCTGTAATT
CCAGGTGGCCGTGATTTCTTTCTTCCCCACTGCCCACTCCTTCGCCAAACCCACGTATTCAGTGTTCTGATCTTGTTTGTGCAGAGTGAA
CTCTGATGCAGTATCAGTCTTGTCCTGGGAGCCGGGTCCTGCTGCTCACAAGCCCAGAGCTGCCAGGGAGCTCCTGGCAGTAGCACGTTG
TTTAGAAAGTTGGGTGGCTTCATTCAGCATGGAACAAGCTAATGGCACAGGAGACATCAGGGCAGCTGTTAATTCCAAATATTTGTTCCC
AAGTAGCTACTGAACTGCTCACACCATTGGAAGATTTTGTATTTTCATACCAATTAGTAAAAATAAGAACATTGAGGAGCAGTCAGAGCC
CAGTGTTAATCTCCGGCAGAGATGGGGTTTATGTATGTTCAGCCAGATAGTAAATGGGATTTTTGGAGAAATAAGATAACTACAAAGTTT
CTATACTTACTATAAGTGGATTTAGAAGCGATTTTGGTTTTGTATTACATACGGTAGTCCTCTGCGTCAGGGAGCACTTTTTTGTTTGCC
TCGAGACTACTCATTAGCGCACTGGCTAAGCTGCCTTTGCCTTCTCGTAGGCGTGGGTTGCCTGTGTCATGGGCTGTGTAGACCACAACA
CTCAAACACAGTTGCTGCACTTGGATTTTCCTTTAATACCAAGTATCATTTGGTTATCTTACTGGGACATTTTCATTGATATTCTATACA
CCAAAGTTTTGACGGTTTACCATCATTCCATTTTGTACCAGTTAAAGGCATTTTGATGATGCTTTTTCTTGATGCTAAGATCACTGCAGA
AGAATAACCTGACCTTTTCTTTGCATTTGTTTTGAATGTCTAACACCATTAGCTTTTGTGATCTGGTTAAGAAGTATTAGTGCCACAAGC
CTGAAAAGACAGTTCTCCTGTGGCAGTGGCGATGTGGCATCCAGAGGGCCATTGTTTCTACTTTTGTGGGACTTCAGTCATGCTGATAAT
AGAATCTTCTGTTCATACAATTCTGTAATATTTATTTGTACAGTTAGTATTCTAATGAAAGGATGAAGAGTCTGAACTAGAAGGTAGGTT
TAAGCCATCACCAGGCCTTTGCAAATGGCCTAAATGGTGTTCCCTTTGAAATAACGCTTGCCACAAGTATATAATAAGCTATATTAATTG
TGTTTTGCATAAAATTGCCAAAACACAGTAATGTGTATATAGTGGTATAAGATCTTGAAAAAAATCTCTATAATTGTGCTCTTTATCTGT
GAATGGGAAAAGCCATTTTTAGTAGGTGACTACCATTTGAAAAACTCAATTGGATGTATATCTGAATGTTGCATTGTATTGTACAGTATG
CATATTATTGTTTGTGGTTGCATATGGCAATGAAGTGTTTGTTTTATATTAAAAAAAACCTGTTATGTACAGTTGAAATAAATTTTGCAT

>51523_51523_14_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000544786_ARHGEF7_chr13_111806252_ENST00000375741_length(amino acids)=737AA_BP=
MSNIREFLRGCGASLRLELLFPPSQPPQHLVTTILLSASTFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDS
LGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEK
PVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEEC
TKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMED
YHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPR
MSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSS
KHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDE
EFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYR

--------------------------------------------------------------
>51523_51523_15_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000544786_ARHGEF7_chr13_111870026_ENST00000317133_length(transcript)=3104nt_BP=119nt
ATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAACCTCTCGTAC
ATCGGCGAGGGCGCCTACGGCATGGTGTGGACATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGTTTAACTTCCAGCAGA
CCAATGAGGACGAGCTTTCCTTCTCAAAAGGAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCACACTCAACG
GCCGGACCGGCTGGTTCCCCAGCAACTACGTGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTGTCTCCCAAATCAGGAACACTGAAGAGCC
CTCCCAAAGGATTTGATACGACTGCCATAAACAAAAGCTATTACAATGTGGTGCTACAGAATATTTTAGAAACAGAAAATGAATATTCTA
AAGAACTTCAGACTGTGCTTTCAACGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAATGGGAA
ATCTAGAAGAAATATGTTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGAGAGTCGGAG
GCTGCTTTTTAAACCTGATGCCACAGATGAAAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCCTCACGGAAC
ACAGTGAGGAGTTGGGGGAGTTCATGGAGACCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAACCCTTCA
TGCGCCTGGATAAATACCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTCAAAAATCCA
TGGCTGCCTTCAAAAACCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAGCCATCCGGA
ACTGGGAGGGCGATGACATTAAAACTCTGGGCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAAAGAATG
AAAGATATCTTCTACTCTTCCCAAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGCTTCCAA
CGACAGGAATGACAATCACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGCGGATATTAG
TGTCGTGCAACAACCAGCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACCCCACCATAA
AGCCTCATTCAGTGCCATCTCATACCCTCCCCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGCTGACGC
CCGCCTACCACACGCTGCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGAAAACACCCA
AGCCCTGGAGCCTGAGCTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTAAGAGCCCTA
AGACCATGAAAAAGCTGCTGCCCAAGCGCAAACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTGCTTTGG
AAGAAGATGCTCAGATTCTGAAAGTCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAACATGGCAAGGCACTG
ACCTGATGCATAATCACGTCTTGGCTGATGATGACCAACCAAGCCTAGACTCCCTGGGGCGTCGCAGTAGCCTTTCTCGTTTGGAGCCTT
CAGACCTCTCGGAAGACTCTGACTATGACAGTATATGGACAGCCCATAGTTACAGAATGGGTTCTACATCTCGTAAGAGCTGTTGCTCAT
ATATCTCTCACCAGAACTAATGCACTTCTGAGCTTTTCTTAACAAATGCTTGTTGTATCGCAGCCTGCTTTTCTTAGATGTTTTCTTGCT
GTTCCTTGTCTCTTTTATGTGATATTTTAACAACTTTTGAGAGTGTTCCTGATATTTCCCATTGTACTTTGTGGAGGCTTAACTGCCGAT
GCGAGTATACATTCGAATGACTGACTATTGGAGGGAGGTGGTGTGTTCACGTGAGCCTACATCCGAGGGTGCTCTTCGTAAGGGGTAGTT
GTTGTTTTATAGCTCCAAATGGTTTTTTTATTCTCAGTGTAGCAACTGTTTGATTTCTTTCTGGATACAGCTGTATGAACACTTTTCTAT
TTTATACTGAAATCACACAGGTTTGTGATCTAAGTGCCAGAACCATGGAGGAGACTCTGGCCTTATCTGTAGGGACCTAAATTTTTTAAG
TGCTATGAACACTGATCAAGTAGTTGTGGAGAGATGAGAAGAATATATGCAGCAAAGGTGCTGTGAGCCCAGTTCCAACGGCTGTGTTCT
GGTAATCGTGCAGAACAGCATGTGGGCTCTGGGCCTTGGCAGGTGCACAGACGGGCGGGCGTCACGTGTGTTCAGAGCTTGTCTCCACCT
CACGGCTCTGTGCTCTTCTGTGTGCTGCGTTGTGGCCGTGAAGTGGGAGCTCTCCTTTCCAAAGGCAGAGCTTACTGTCATGGCTCAGAT
GTTCACTCGCATCTTCACCCCAAACTTCCCTGAATTGCAGTGATTTCTGTTATAAGGCACATAGCAAGCCTGTACCACTCTACAGTAAAA
TCTCTACACTAACAGTTTAAAGCCCGAAAGCTGAAGCATTCAGCCTCTGCAAGTGTAGACTACTGGACTGTAGTAGAGGCATTTGGAATA
CTTACAAAGTCAAGTGCTGTGGCTTCAGTTCCCCCGGCTCCCCACCCCTGACATCCATACTTATGTTGTCTGGAAGAGCCATGGACACAT
CATTATTTTCAGCAACCAGCTGCAGTGAAACTCCATTTACAGCAACCCCATAGTATAAAACCACAATGCCTCATTGTAATGGGATATTGA

>51523_51523_15_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000544786_ARHGEF7_chr13_111870026_ENST00000317133_length(amino acids)=625AA_BP=0
MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAIN
KSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQC
QEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSH
HGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE

--------------------------------------------------------------
>51523_51523_16_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000544786_ARHGEF7_chr13_111870026_ENST00000370623_length(transcript)=4681nt_BP=119nt
ATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAACCTCTCGTAC
ATCGGCGAGGGCGCCTACGGCATGGTGTGGACATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGTTTAACTTCCAGCAGA
CCAATGAGGACGAGCTTTCCTTCTCAAAAGGAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCACACTCAACG
GCCGGACCGGCTGGTTCCCCAGCAACTACGTGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTGTCTCCCAAATCAGGAACACTGAAGAGCC
CTCCCAAAGGATTTGATACGACTGCCATAAACAAAAGCTATTACAATGTGGTGCTACAGAATATTTTAGAAACAGAAAATGAATATTCTA
AAGAACTTCAGACTGTGCTTTCAACGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAATGGGAA
ATCTAGAAGAAATATGTTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGAGAGTCGGAG
GCTGCTTTTTAAACCTGATGCCACAGATGAAAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCCTCACGGAAC
ACAGTGAGGAGTTGGGGGAGTTCATGGAGACCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAACCCTTCA
TGCGCCTGGATAAATACCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTCAAAAATCCA
TGGCTGCCTTCAAAAACCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAGCCATCCGGA
ACTGGGAGGGCGATGACATTAAAACTCTGGGCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAAAGAATG
AAAGATATCTTCTACTCTTCCCAAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGCTTCCAA
CGACAGGAATGACAATCACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGCGGATATTAG
TGTCGTGCAACAACCAGCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACCCCACCATAA
AGCCTCATTCAGTGCCATCTCATACCCTCCCCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGCTGACGC
CCGCCTACCACACGCTGCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGAAAACACCCA
AGCCCTGGAGCCTGAGCTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTAAGAGCCCTA
AGACCATGAAAAAGCTGCTGCCCAAGCGCAAACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTGCTTTGG
AAGAAGATGCTCAGATTCTGAAAGTCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAAGTTCACGCAAAGAAT
CTGCTCCACAAGTTTTGCTTCCAGAAGAAGAGAAAATTATAGTGGAAGAAACTAAAAGTAATGGTCAGACAGTGATAGAAGAAAAGAGTC
TTGTGGATACCGTATATGCATTAAAGGATGAAGTTCAAGAATTAAGACAGGACAACAAAAAGATGAAGAAATCTCTAGAGGAAGAACAGA
GAGCCCGCAAAGACCTGGAGAAGCTGGTGAGGAAAGTCCTGAAGAACATGAATGATCCTGCCTGGGATGAGACCAATCTATAAGGGATGT
CCTCAGTTCTTTCTGTTGAAGACCAGTTCTGAGGTGAAGCTGGGCACCCCTGACCCAAGTCGGGGTGCACTCAGGACCACAGGGCAGGGC
TGGGTGGGGCGCCACCTTGCTCTCTGTATATAGAAAAGCTGGAGCTTATTCTGCGAATGGAGACGATCAAACCATGACTGATGAATCCAG
ACAGGAGGGATTGACTCTGAGGACCTGAGCTACATCAATCCACTCTGTGAACATCTCAGTTACCTCATTCTGCAATAAGTTCAGTGACTG
ACTAAAAGTCTTGTTTTTCCAGACTTTGAATTGAATATATAAATATTATATATACATGTTTCTTGTAAATATCCCATTTTGAATGCATAC
CTGTGGTGGTTCTGTCCGGGCTAATCCCCATGCTAGAATGTCCTTTCCAGCTACGTGAATAAGAAGTCCCATGCCCGCATCCACCGGAAG
CAGAAGCCTGGTGGATGCCTGGTTCGTTCCGCAGCACCAGGGCCTCCACCGTGCTGTGGCAGCACCCCCCATGTCGGTATTTCTAAATAA
CCTTATTTATACCTGCAGAGATACACTTCAGTCCCATTCAGAAGTCTTCTCTTAAAGCAGCATTACAGTCCCAGACCTGCGGGTTTCTGA
GGGCAACTTGCTGGCTGACAGACTCAGTCTTGACCTCAAGGAAGGCCCATACGGCACTGCCGCATCCACCTAGAGGTGTTTGCTCTTGTC
CGCTGTCTGAGTACTGTGATTCTCAGATGAGTTTGCTGCGTTTTGGGAGGACACAGACGGTTCTGTATAGGCTAGTTCAGTAACAACAAA
ATACACTGTTTTGTCTTCCCTCAAAGAGAGATCTTACTAGAACCTGTAAATAGAATGTATTATTTATTATAAGTCACTGCAGCTGATGAA
AACAGATGGAGGCCATGCTGCAGGCTGATACTGATGGGTGGAGTTTTGTCATCAGGCCAGCCTCATCCCGAGGTCTCCTCCACCATTGGC
CGTAGCCAGCAGGCTTCAGTGCTCACCGAAAGTAAAATCCCCTCCTTCAGCAAGAATAAAGCAATATACACCTTAGGTTCCACTAAGTAA
CATAGGCATAAGCAGGGAACGTTTCCCCCACTGTGTTCCAGTGCAGAGGAGACGAAGCCTGTCCTCACCGCGGCTCGCTGGGCCCAGGCT
GGCTCTGGAAAGCCTGTGCGGTCCTGGGCAGGAAGCCCGGCCCGTGGAGCAGGTTTTCGTTCTGCTTCAGCAATAAATAAGGGTGACCAC
AGGGACTTTGCTTTTGGTTTCCTTTCCTGTGAAAAGGTTGGTTTTAAAGTGAGATACACTTTTCCGTAGAACAAGTGTTCTATCTTTAAA
AACCCAAATTGCAGCACCGTGGATTACTGGTCTCAGAACAACTCATTGCGCATCAGATTTGACTCTCTGATTTTCTGTCTATTGGCCAAA
TTGCCCTTTAACTGCACCTGAATCCTTTGTGTACTGATGCCTTTGAGCTGGGCACCTTGGGAGAGTGTTGTGTTGCTGTTTACGGTTCTT
CCTTGCCCTTGCTAATTACAGTCTCTGGTGCCCAGCAAGCCCCTTTGGCTTCCTTCCGTGACTGGTCACGTTGTCTGCCTGGGCTCAGCG
TGGACCTGCCCCATGCTGCAGAACCTGGCCTCACCTGGACTTTTCACTAGAATTGCCAGCTTCCTCAACTTAGCAGATCATTCACTCATG
CGGGCACAAGCAAAGATCAACACTTTCTTTTTTGGTAAGCTTGAGTTTTACAAGTTATTTTTTGGTGATGCGTAAGACATTGCAGTGGGA
AACCATTCAACTTGAGTTTATTGGAGTTTGCTGTTGTAGCAGGTTTTAACTCAGGAACAACTCTTGTCTGATCTCTCCGCCCCTCTGCCG
GGAGGCGACATTAACTGTCCTCTCGGAGCCGGTAGCGTTGCTGTCCGAGTCCCCAGGACGGATCTCCTGCAGACCTGCCTTAATGCTCAG
ATCGAAGTATTTCACAAGAATACTTGTGTTTTTAACAGCCCTTCCCCTGGACGGTGCGGCCATGAGGGCCTCATGTTACGGCATTGCCTT
TTCTTTCTGTGGATCCAGTATCTTCCTCGGCTTTTTAGGGAGCAGGAAAAATGCGTCTGAGAGCAACTCTTTTTAAAAACCTGCCCTGTT
GTATATAACTGTGTCTGTTTCACCGTGTGACCTCCCAAGGGGGTGGGAACTTGATATAAACGTTTAAAGGGGCCACGATTTGCCCGAGGG
TTACTCCTTTGCTCTCACCTTGTATGGATGAGGAGATGAAGCCATTTCTTATCCTGTAGATGTGAAGCACTTTCAGTTTTCAGCGATGTT
GGAATGTAGCATCAGAAGCTCGTTCCTTCACACTCAGTGGCGTCTGTGCTTGTCCACATGCGCTGGGCGTCTGGGACCTTGAATGCCTGC
CCTGGTTGTGTGGACTCCTTAATGCCAATCATTTCTTCACTTCTCTGGGACACCCAGGGCGCCTGTTGACAAGTGTGGAGAAACTCCTAA
TTTAAATGTCACAGACAATGTCCTAGTGTTGACTACTACAATGTTGATGCTACACTGTTGTAATTATTAAACTGATTATTTTTCTTATGT

>51523_51523_16_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000544786_ARHGEF7_chr13_111870026_ENST00000370623_length(amino acids)=646AA_BP=0
MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAIN
KSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQC
QEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSH
HGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
AYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVR

--------------------------------------------------------------
>51523_51523_17_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000544786_ARHGEF7_chr13_111870026_ENST00000375739_length(transcript)=4863nt_BP=119nt
ATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAACCTCTCGTAC
ATCGGCGAGGGCGCCTACGGCATGGTGTGGACATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGTTTAACTTCCAGCAGA
CCAATGAGGACGAGCTTTCCTTCTCAAAAGGAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCACACTCAACG
GCCGGACCGGCTGGTTCCCCAGCAACTACGTGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTGTCTCCCAAATCAGGAACACTGAAGAGCC
CTCCCAAAGGATTTGATACGACTGCCATAAACAAAAGCTATTACAATGTGGTGCTACAGAATATTTTAGAAACAGAAAATGAATATTCTA
AAGAACTTCAGACTGTGCTTTCAACGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAATGGGAA
ATCTAGAAGAAATATGTTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGAGAGTCGGAG
GCTGCTTTTTAAACCTGATGCCACAGATGAAAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCCTCACGGAAC
ACAGTGAGGAGTTGGGGGAGTTCATGGAGACCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAACCCTTCA
TGCGCCTGGATAAATACCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTCAAAAATCCA
TGGCTGCCTTCAAAAACCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAGCCATCCGGA
ACTGGGAGGGCGATGACATTAAAACTCTGGGCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAAAGAATG
AAAGATATCTTCTACTCTTCCCAAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGCTTCCAA
CGACAGGAATGACAATCACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGCGGATATTAG
TGTCGTGCAACAACCAGCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACCCCACCATAA
AGCCTCATTCAGTGCCATCTCATACCCTCCCCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGCTGACGC
CCGCCTACCACACGCTGCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGAAAACACCCA
AGCCCTGGAGCCTGAGCTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTAAGAGCCCTA
AGACCATGAAAAAGCTGCTGCCCAAGCGCAAACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTGCTTTGG
AAGAAGATGCTCAGATTCTGAAAGTCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAACATGGCAAGGCACTG
ACCTGATGCATAATCACGTCTTGGCTGATGATGACCAACCAAGCCTAGACTCCCTGGGGCGTCGCAGTAGCCTTTCTCGTTTGGAGCCTT
CAGACCTCTCGGAAGACTCTGACTATGACAGTATATGGACAGCCCATAGTTACAGAATGGGTTCTACATCTCGTAAGAGCTGTTGCTCAT
ATATCTCTCACCAGAACTAATGCACTTCTGAGCTTTTCTTAACAAATGCTTGTTGTATCGCAGCCTGCTTTTCTTAGATGTTTTCTTGCT
GTTCCTTGTCTCTTTTATGTGATATTTTAACAACTTTTGAGAGTGTTCCTGATATTTCCCATTGTACTTTGTGGAGGCTTAACTGCCGAT
GCGAGTATACATTCGAATGACTGACTATTGGAGGGAGGTGGTGTGTTCACGTGAGCCTACATCCGAGGGTGCTCTTCGTAAGGGGTAGTT
GTTGTTTTATAGCTCCAAATGGTTTTTTTATTCTCAGTGTAGCAACTGTTTGATTTCTTTCTGGATACAGCTGTATGAACACTTTTCTAT
TTTATACTGAAATCACACAGGTTTGTGATCTAAGTGCCAGAACCATGGAGGAGACTCTGGCCTTATCTGTAGGGACCTAAATTTTTTAAG
TGCTATGAACACTGATCAAGTAGTTGTGGAGAGATGAGAAGAATATATGCAGCAAAGGTGCTGTGAGCCCAGTTCCAACGGCTGTGTTCT
GGTAATCGTGCAGAACAGCATGTGGGCTCTGGGCCTTGGCAGGTGCACAGACGGGCGGGCGTCACGTGTGTTCAGAGCTTGTCTCCACCT
CACGGCTCTGTGCTCTTCTGTGTGCTGCGTTGTGGCCGTGAAGTGGGAGCTCTCCTTTCCAAAGGCAGAGCTTACTGTCATGGCTCAGAT
GTTCACTCGCATCTTCACCCCAAACTTCCCTGAATTGCAGTGATTTCTGTTATAAGGCACATAGCAAGCCTGTACCACTCTACAGTAAAA
TCTCTACACTAACAGTTTAAAGCCCGAAAGCTGAAGCATTCAGCCTCTGCAAGTGTAGACTACTGGACTGTAGTAGAGGCATTTGGAATA
CTTACAAAGTCAAGTGCTGTGGCTTCAGTTCCCCCGGCTCCCCACCCCTGACATCCATACTTATGTTGTCTGGAAGAGCCATGGACACAT
CATTATTTTCAGCAACCAGCTGCAGTGAAACTCCATTTACAGCAACCCCATAGTATAAAACCACAATGCCTCATTGTAATGGGATATTGA
AGTTCATTGAAGAATTACTAGGTTGCCATGTGGCTCACTTATTTAAAAAAAAAAAAAAAAAACTCACCCGTTTTCCTGGGATTTGTTGTA
AGGAGTTTTCACTGGCCTCACTCAGACCAATTTCTGCTTCAAAAAGCACTGAATGTGACCTGTTGCATTCAGTTGTAGCATCAAATCCAC
ACCTAGTCATTGCTTGAGGGGCCAAATTGTGTTCTGTCCCATGCACGCTCTATTTGGTGTTAAAATGGAACCTTACGGTTGTGTTTTAAG
TATTCATTGAAACCAGCTTCAGAAAACAAGATGCCATAGTAAATTGAGAATAACATTTTTTCCTTCTTCAGGGTGGCTGTAATTCCAGGT
GGCCGTGATTTCTTTCTTCCCCACTGCCCACTCCTTCGCCAAACCCACGTATTCAGTGTTCTGATCTTGTTTGTGCAGAGTGAACTCTGA
TGCAGTATCAGTCTTGTCCTGGGAGCCGGGTCCTGCTGCTCACAAGCCCAGAGCTGCCAGGGAGCTCCTGGCAGTAGCACGTTGTTTAGA
AAGTTGGGTGGCTTCATTCAGCATGGAACAAGCTAATGGCACAGGAGACATCAGGGCAGCTGTTAATTCCAAATATTTGTTCCCAAGTAG
CTACTGAACTGCTCACACCATTGGAAGATTTTGTATTTTCATACCAATTAGTAAAAATAAGAACATTGAGGAGCAGTCAGAGCCCAGTGT
TAATCTCCGGCAGAGATGGGGTTTATGTATGTTCAGCCAGATAGTAAATGGGATTTTTGGAGAAATAAGATAACTACAAAGTTTCTATAC
TTACTATAAGTGGATTTAGAAGCGATTTTGGTTTTGTATTACATACGGTAGTCCTCTGCGTCAGGGAGCACTTTTTTGTTTGCCTCGAGA
CTACTCATTAGCGCACTGGCTAAGCTGCCTTTGCCTTCTCGTAGGCGTGGGTTGCCTGTGTCATGGGCTGTGTAGACCACAACACTCAAA
CACAGTTGCTGCACTTGGATTTTCCTTTAATACCAAGTATCATTTGGTTATCTTACTGGGACATTTTCATTGATATTCTATACACCAAAG
TTTTGACGGTTTACCATCATTCCATTTTGTACCAGTTAAAGGCATTTTGATGATGCTTTTTCTTGATGCTAAGATCACTGCAGAAGAATA
ACCTGACCTTTTCTTTGCATTTGTTTTGAATGTCTAACACCATTAGCTTTTGTGATCTGGTTAAGAAGTATTAGTGCCACAAGCCTGAAA
AGACAGTTCTCCTGTGGCAGTGGCGATGTGGCATCCAGAGGGCCATTGTTTCTACTTTTGTGGGACTTCAGTCATGCTGATAATAGAATC
TTCTGTTCATACAATTCTGTAATATTTATTTGTACAGTTAGTATTCTAATGAAAGGATGAAGAGTCTGAACTAGAAGGTAGGTTTAAGCC
ATCACCAGGCCTTTGCAAATGGCCTAAATGGTGTTCCCTTTGAAATAACGCTTGCCACAAGTATATAATAAGCTATATTAATTGTGTTTT
GCATAAAATTGCCAAAACACAGTAATGTGTATATAGTGGTATAAGATCTTGAAAAAAATCTCTATAATTGTGCTCTTTATCTGTGAATGG
GAAAAGCCATTTTTAGTAGGTGACTACCATTTGAAAAACTCAATTGGATGTATATCTGAATGTTGCATTGTATTGTACAGTATGCATATT
ATTGTTTGTGGTTGCATATGGCAATGAAGTGTTTGTTTTATATTAAAAAAAACCTGTTATGTACAGTTGAAATAAATTTTGCATTTGCTA

>51523_51523_17_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000544786_ARHGEF7_chr13_111870026_ENST00000375739_length(amino acids)=625AA_BP=0
MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAIN
KSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQC
QEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSH
HGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE

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>51523_51523_18_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000544786_ARHGEF7_chr13_111870026_ENST00000375741_length(transcript)=4863nt_BP=119nt
ATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAACCTCTCGTAC
ATCGGCGAGGGCGCCTACGGCATGGTGTGGACATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGTTTAACTTCCAGCAGA
CCAATGAGGACGAGCTTTCCTTCTCAAAAGGAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCACACTCAACG
GCCGGACCGGCTGGTTCCCCAGCAACTACGTGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTGTCTCCCAAATCAGGAACACTGAAGAGCC
CTCCCAAAGGATTTGATACGACTGCCATAAACAAAAGCTATTACAATGTGGTGCTACAGAATATTTTAGAAACAGAAAATGAATATTCTA
AAGAACTTCAGACTGTGCTTTCAACGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAATGGGAA
ATCTAGAAGAAATATGTTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAGCTCAGCAGAGAGTCGGAG
GCTGCTTTTTAAACCTGATGCCACAGATGAAAACCCTGTACCTCACGTATTGTGCCAATCACCCTTCTGCAGTGAATGTCCTCACGGAAC
ACAGTGAGGAGTTGGGGGAGTTCATGGAGACCAAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAACCCTTCA
TGCGCCTGGATAAATACCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTCAAAAATCCA
TGGCTGCCTTCAAAAACCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAGCTGCAGATCCTGACGGAAGCCATCCGGA
ACTGGGAGGGCGATGACATTAAAACTCTGGGCAACGTCACTTACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAAAGAATG
AAAGATATCTTCTACTCTTCCCAAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGCTTCCAA
CGACAGGAATGACAATCACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCATGATTGAGCGGATATTAG
TGTCGTGCAACAACCAGCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAAGCAAACGAAGGTCACGTCTGTGGGAAACCCCACCATAA
AGCCTCATTCAGTGCCATCTCATACCCTCCCCTCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGCTGACGC
CCGCCTACCACACGCTGCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGAAAACACCCA
AGCCCTGGAGCCTGAGCTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGCTACAAGGAGGATCTTAGTAAGAGCCCTA
AGACCATGAAAAAGCTGCTGCCCAAGCGCAAACCTGAACGGAAGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTGCTTTGG
AAGAAGATGCTCAGATTCTGAAAGTCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAACATGGCAAGGCACTG
ACCTGATGCATAATCACGTCTTGGCTGATGATGACCAACCAAGCCTAGACTCCCTGGGGCGTCGCAGTAGCCTTTCTCGTTTGGAGCCTT
CAGACCTCTCGGAAGACTCTGACTATGACAGTATATGGACAGCCCATAGTTACAGAATGGGTTCTACATCTCGTAAGAGCTGTTGCTCAT
ATATCTCTCACCAGAACTAATGCACTTCTGAGCTTTTCTTAACAAATGCTTGTTGTATCGCAGCCTGCTTTTCTTAGATGTTTTCTTGCT
GTTCCTTGTCTCTTTTATGTGATATTTTAACAACTTTTGAGAGTGTTCCTGATATTTCCCATTGTACTTTGTGGAGGCTTAACTGCCGAT
GCGAGTATACATTCGAATGACTGACTATTGGAGGGAGGTGGTGTGTTCACGTGAGCCTACATCCGAGGGTGCTCTTCGTAAGGGGTAGTT
GTTGTTTTATAGCTCCAAATGGTTTTTTTATTCTCAGTGTAGCAACTGTTTGATTTCTTTCTGGATACAGCTGTATGAACACTTTTCTAT
TTTATACTGAAATCACACAGGTTTGTGATCTAAGTGCCAGAACCATGGAGGAGACTCTGGCCTTATCTGTAGGGACCTAAATTTTTTAAG
TGCTATGAACACTGATCAAGTAGTTGTGGAGAGATGAGAAGAATATATGCAGCAAAGGTGCTGTGAGCCCAGTTCCAACGGCTGTGTTCT
GGTAATCGTGCAGAACAGCATGTGGGCTCTGGGCCTTGGCAGGTGCACAGACGGGCGGGCGTCACGTGTGTTCAGAGCTTGTCTCCACCT
CACGGCTCTGTGCTCTTCTGTGTGCTGCGTTGTGGCCGTGAAGTGGGAGCTCTCCTTTCCAAAGGCAGAGCTTACTGTCATGGCTCAGAT
GTTCACTCGCATCTTCACCCCAAACTTCCCTGAATTGCAGTGATTTCTGTTATAAGGCACATAGCAAGCCTGTACCACTCTACAGTAAAA
TCTCTACACTAACAGTTTAAAGCCCGAAAGCTGAAGCATTCAGCCTCTGCAAGTGTAGACTACTGGACTGTAGTAGAGGCATTTGGAATA
CTTACAAAGTCAAGTGCTGTGGCTTCAGTTCCCCCGGCTCCCCACCCCTGACATCCATACTTATGTTGTCTGGAAGAGCCATGGACACAT
CATTATTTTCAGCAACCAGCTGCAGTGAAACTCCATTTACAGCAACCCCATAGTATAAAACCACAATGCCTCATTGTAATGGGATATTGA
AGTTCATTGAAGAATTACTAGGTTGCCATGTGGCTCACTTATTTAAAAAAAAAAAAAAAAAACTCACCCGTTTTCCTGGGATTTGTTGTA
AGGAGTTTTCACTGGCCTCACTCAGACCAATTTCTGCTTCAAAAAGCACTGAATGTGACCTGTTGCATTCAGTTGTAGCATCAAATCCAC
ACCTAGTCATTGCTTGAGGGGCCAAATTGTGTTCTGTCCCATGCACGCTCTATTTGGTGTTAAAATGGAACCTTACGGTTGTGTTTTAAG
TATTCATTGAAACCAGCTTCAGAAAACAAGATGCCATAGTAAATTGAGAATAACATTTTTTCCTTCTTCAGGGTGGCTGTAATTCCAGGT
GGCCGTGATTTCTTTCTTCCCCACTGCCCACTCCTTCGCCAAACCCACGTATTCAGTGTTCTGATCTTGTTTGTGCAGAGTGAACTCTGA
TGCAGTATCAGTCTTGTCCTGGGAGCCGGGTCCTGCTGCTCACAAGCCCAGAGCTGCCAGGGAGCTCCTGGCAGTAGCACGTTGTTTAGA
AAGTTGGGTGGCTTCATTCAGCATGGAACAAGCTAATGGCACAGGAGACATCAGGGCAGCTGTTAATTCCAAATATTTGTTCCCAAGTAG
CTACTGAACTGCTCACACCATTGGAAGATTTTGTATTTTCATACCAATTAGTAAAAATAAGAACATTGAGGAGCAGTCAGAGCCCAGTGT
TAATCTCCGGCAGAGATGGGGTTTATGTATGTTCAGCCAGATAGTAAATGGGATTTTTGGAGAAATAAGATAACTACAAAGTTTCTATAC
TTACTATAAGTGGATTTAGAAGCGATTTTGGTTTTGTATTACATACGGTAGTCCTCTGCGTCAGGGAGCACTTTTTTGTTTGCCTCGAGA
CTACTCATTAGCGCACTGGCTAAGCTGCCTTTGCCTTCTCGTAGGCGTGGGTTGCCTGTGTCATGGGCTGTGTAGACCACAACACTCAAA
CACAGTTGCTGCACTTGGATTTTCCTTTAATACCAAGTATCATTTGGTTATCTTACTGGGACATTTTCATTGATATTCTATACACCAAAG
TTTTGACGGTTTACCATCATTCCATTTTGTACCAGTTAAAGGCATTTTGATGATGCTTTTTCTTGATGCTAAGATCACTGCAGAAGAATA
ACCTGACCTTTTCTTTGCATTTGTTTTGAATGTCTAACACCATTAGCTTTTGTGATCTGGTTAAGAAGTATTAGTGCCACAAGCCTGAAA
AGACAGTTCTCCTGTGGCAGTGGCGATGTGGCATCCAGAGGGCCATTGTTTCTACTTTTGTGGGACTTCAGTCATGCTGATAATAGAATC
TTCTGTTCATACAATTCTGTAATATTTATTTGTACAGTTAGTATTCTAATGAAAGGATGAAGAGTCTGAACTAGAAGGTAGGTTTAAGCC
ATCACCAGGCCTTTGCAAATGGCCTAAATGGTGTTCCCTTTGAAATAACGCTTGCCACAAGTATATAATAAGCTATATTAATTGTGTTTT
GCATAAAATTGCCAAAACACAGTAATGTGTATATAGTGGTATAAGATCTTGAAAAAAATCTCTATAATTGTGCTCTTTATCTGTGAATGG
GAAAAGCCATTTTTAGTAGGTGACTACCATTTGAAAAACTCAATTGGATGTATATCTGAATGTTGCATTGTATTGTACAGTATGCATATT
ATTGTTTGTGGTTGCATATGGCAATGAAGTGTTTGTTTTATATTAAAAAAAACCTGTTATGTACAGTTGAAATAAATTTTGCATTTGCTA

>51523_51523_18_MAPK1-ARHGEF7_MAPK1_chr22_22221612_ENST00000544786_ARHGEF7_chr13_111870026_ENST00000375741_length(amino acids)=625AA_BP=0
MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAIN
KSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQC
QEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSH
HGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE

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Fusion Gene PPI Analysis for MAPK1-ARHGEF7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAPK1-ARHGEF7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAPK1-ARHGEF7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAPK1C0009171Cocaine Abuse2CTD_human
HgeneMAPK1C0020429Hyperalgesia2CTD_human
HgeneMAPK1C0024121Lung Neoplasms2CTD_human
HgeneMAPK1C0236736Cocaine-Related Disorders2CTD_human
HgeneMAPK1C0242379Malignant neoplasm of lung2CTD_human
HgeneMAPK1C0458247Allodynia2CTD_human
HgeneMAPK1C0600427Cocaine Dependence2CTD_human
HgeneMAPK1C0751211Hyperalgesia, Primary2CTD_human
HgeneMAPK1C0751212Hyperalgesia, Secondary2CTD_human
HgeneMAPK1C0751213Tactile Allodynia2CTD_human
HgeneMAPK1C0751214Hyperalgesia, Thermal2CTD_human
HgeneMAPK1C2936719Mechanical Allodynia2CTD_human
HgeneMAPK1C0005398Cholestasis, Extrahepatic1CTD_human
HgeneMAPK1C0005586Bipolar Disorder1PSYGENET
HgeneMAPK1C0007137Squamous cell carcinoma1CTD_human
HgeneMAPK1C0007786Brain Ischemia1CTD_human
HgeneMAPK1C0017639Gliosis1CTD_human
HgeneMAPK1C0018671Head and Neck Neoplasms1CTD_human
HgeneMAPK1C0018675Head Neoplasms1CTD_human
HgeneMAPK1C0019207Hepatoma, Morris1CTD_human
HgeneMAPK1C0019208Hepatoma, Novikoff1CTD_human
HgeneMAPK1C0020564Hypertrophy1CTD_human
HgeneMAPK1C0021361Female infertility1CTD_human
HgeneMAPK1C0022665Kidney Neoplasm1CTD_human
HgeneMAPK1C0023904Liver Neoplasms, Experimental1CTD_human
HgeneMAPK1C0024623Malignant neoplasm of stomach1CTD_human
HgeneMAPK1C0027533Neck Neoplasms1CTD_human
HgeneMAPK1C0027626Neoplasm Invasiveness1CTD_human
HgeneMAPK1C0027627Neoplasm Metastasis1CTD_human
HgeneMAPK1C0027746Nerve Degeneration1CTD_human
HgeneMAPK1C0033141Cardiomyopathies, Primary1CTD_human
HgeneMAPK1C0034189Pyemia1CTD_human
HgeneMAPK1C0036341Schizophrenia1PSYGENET
HgeneMAPK1C0036529Myocardial Diseases, Secondary1CTD_human
HgeneMAPK1C0036690Septicemia1CTD_human
HgeneMAPK1C0036920Sezary Syndrome1CTD_human
HgeneMAPK1C0038279Sterility, Postpartum1CTD_human
HgeneMAPK1C0038356Stomach Neoplasms1CTD_human
HgeneMAPK1C0038587Substance Withdrawal Syndrome1CTD_human
HgeneMAPK1C0040997Trigeminal Neuralgia1CTD_human
HgeneMAPK1C0086189Drug Withdrawal Symptoms1CTD_human
HgeneMAPK1C0086404Experimental Hepatoma1CTD_human
HgeneMAPK1C0087031Juvenile-Onset Still Disease1CTD_human
HgeneMAPK1C0087169Withdrawal Symptoms1CTD_human
HgeneMAPK1C0155862Streptococcal pneumonia1CTD_human
HgeneMAPK1C0178417Anhedonia1PSYGENET
HgeneMAPK1C0243026Sepsis1CTD_human
HgeneMAPK1C0278996Malignant Head and Neck Neoplasm1CTD_human
HgeneMAPK1C0341869Subfertility, Female1CTD_human
HgeneMAPK1C0393786Trigeminal Neuralgia, Idiopathic1CTD_human
HgeneMAPK1C0393787Secondary Trigeminal Neuralgia1CTD_human
HgeneMAPK1C0740457Malignant neoplasm of kidney1CTD_human
HgeneMAPK1C0746787Cancer of Neck1CTD_human
HgeneMAPK1C0751177Cancer of Head1CTD_human
HgeneMAPK1C0878544Cardiomyopathies1CTD_human
HgeneMAPK1C0887900Upper Aerodigestive Tract Neoplasms1CTD_human
HgeneMAPK1C0917730Female sterility1CTD_human
HgeneMAPK1C0917798Cerebral Ischemia1CTD_human
HgeneMAPK1C0919267ovarian neoplasm1CTD_human
HgeneMAPK1C1140680Malignant neoplasm of ovary1CTD_human
HgeneMAPK1C1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneMAPK1C1719672Severe Sepsis1CTD_human
HgeneMAPK1C1866282CEROID LIPOFUSCINOSIS, NEURONAL, 61CTD_human
HgeneMAPK1C3495559Juvenile arthritis1CTD_human
HgeneMAPK1C3714758Juvenile psoriatic arthritis1CTD_human
HgeneMAPK1C3887640Astrocytosis1CTD_human
HgeneMAPK1C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneMAPK1C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human