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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACPP-RNF13 (FusionGDB2 ID:HG55TG11342)

Fusion Gene Summary for ACPP-RNF13

check button Fusion gene summary
Fusion gene informationFusion gene name: ACPP-RNF13
Fusion gene ID: hg55tg11342
HgeneTgene
Gene symbol

ACPP

RNF13

Gene ID

55

11342

Gene nameacid phosphatase 3ring finger protein 13
Synonyms5'-NT|ACP-3|ACPP|TM-PAPEIEE73|RZF
Cytomap('ACPP')('RNF13')

3q22.1

3q25.1

Type of geneprotein-codingprotein-coding
Descriptionprostatic acid phosphataseTMPaseacid phosphatase, prostateecto-5'-nucleotidaseprostatic acid phosphotasethiamine monophosphataseE3 ubiquitin-protein ligase RNF13RING zinc finger proteinRING-type E3 ubiquitin transferase RNF13
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000489084, ENST00000336375, 
ENST00000351273, ENST00000475741, 
Fusion gene scores* DoF score28 X 17 X 4=190417 X 12 X 8=1632
# samples 3117
** MAII scorelog2(31/1904*10)=-2.61869335803371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1632*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACPP [Title/Abstract] AND RNF13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACPP(132036420)-RNF13(149613260), # samples:1
Anticipated loss of major functional domain due to fusion event.ACPP-RNF13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACPP-RNF13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACPP-RNF13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACPP-RNF13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACPP

GO:0046085

adenosine metabolic process

18940592


check buttonFusion gene breakpoints across ACPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RNF13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315376ACPPchr3

132036420

+RNF13chr3

149613260

+


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Fusion Gene ORF analysis for ACPP-RNF13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000489084ENST00000344229ACPPchr3

132036420

+RNF13chr3

149613260

+
3UTR-3CDSENST00000489084ENST00000392894ACPPchr3

132036420

+RNF13chr3

149613260

+
3UTR-5UTRENST00000489084ENST00000361785ACPPchr3

132036420

+RNF13chr3

149613260

+
5CDS-5UTRENST00000336375ENST00000361785ACPPchr3

132036420

+RNF13chr3

149613260

+
5CDS-5UTRENST00000351273ENST00000361785ACPPchr3

132036420

+RNF13chr3

149613260

+
5CDS-5UTRENST00000475741ENST00000361785ACPPchr3

132036420

+RNF13chr3

149613260

+
In-frameENST00000336375ENST00000344229ACPPchr3

132036420

+RNF13chr3

149613260

+
In-frameENST00000336375ENST00000392894ACPPchr3

132036420

+RNF13chr3

149613260

+
In-frameENST00000351273ENST00000344229ACPPchr3

132036420

+RNF13chr3

149613260

+
In-frameENST00000351273ENST00000392894ACPPchr3

132036420

+RNF13chr3

149613260

+
In-frameENST00000475741ENST00000344229ACPPchr3

132036420

+RNF13chr3

149613260

+
In-frameENST00000475741ENST00000392894ACPPchr3

132036420

+RNF13chr3

149613260

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336375ACPPchr3132036420+ENST00000392894RNF13chr3149613260+2070210661034322
ENST00000336375ACPPchr3132036420+ENST00000344229RNF13chr3149613260+2053210661034322
ENST00000475741ACPPchr3132036420+ENST00000392894RNF13chr3149613260+203117127995322
ENST00000475741ACPPchr3132036420+ENST00000344229RNF13chr3149613260+201417127995322
ENST00000351273ACPPchr3132036420+ENST00000392894RNF13chr3149613260+203017026994322
ENST00000351273ACPPchr3132036420+ENST00000344229RNF13chr3149613260+201317026994322

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336375ENST00000392894ACPPchr3132036420+RNF13chr3149613260+0.0001314540.9998685
ENST00000336375ENST00000344229ACPPchr3132036420+RNF13chr3149613260+0.0001293120.99987066
ENST00000475741ENST00000392894ACPPchr3132036420+RNF13chr3149613260+0.0001272410.9998727
ENST00000475741ENST00000344229ACPPchr3132036420+RNF13chr3149613260+0.0001230330.999877
ENST00000351273ENST00000392894ACPPchr3132036420+RNF13chr3149613260+0.0001268190.99987316
ENST00000351273ENST00000344229ACPPchr3132036420+RNF13chr3149613260+0.0001225120.99987745

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Fusion Genomic Features for ACPP-RNF13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACPPchr3132036420+RNF13chr3149613259+1.57E-091
ACPPchr3132036420+RNF13chr3149613259+1.57E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACPP-RNF13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:132036420/chr3:149613260)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRNF13chr3:132036420chr3:149613260ENST00000344229411204_381107382.0Topological domainCytoplasmic
TgeneRNF13chr3:132036420chr3:149613260ENST00000392894310204_381107382.0Topological domainCytoplasmic
TgeneRNF13chr3:132036420chr3:149613260ENST00000344229411183_203107382.0TransmembraneHelical
TgeneRNF13chr3:132036420chr3:149613260ENST00000392894310183_203107382.0TransmembraneHelical
TgeneRNF13chr3:132036420chr3:149613260ENST00000344229411240_282107382.0Zinc fingerRING-type%3B atypical
TgeneRNF13chr3:132036420chr3:149613260ENST00000392894310240_282107382.0Zinc fingerRING-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRNF13chr3:132036420chr3:149613260ENST0000034422941165_160107382.0DomainNote=PA
TgeneRNF13chr3:132036420chr3:149613260ENST0000039289431065_160107382.0DomainNote=PA
TgeneRNF13chr3:132036420chr3:149613260ENST0000034422941135_182107382.0Topological domainLumenal
TgeneRNF13chr3:132036420chr3:149613260ENST0000039289431035_182107382.0Topological domainLumenal


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Fusion Gene Sequence for ACPP-RNF13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1461_1461_1_ACPP-RNF13_ACPP_chr3_132036420_ENST00000336375_RNF13_chr3_149613260_ENST00000344229_length(transcript)=2053nt_BP=210nt
TCAATCCCTTAATTAAATAGCTTCCCCTCTACAGGCTTTTGAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAAC
ATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCCTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTA
CTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTTTTAAATGCACAGAGAGCAGGATACAAGGCAGCCATAGTTCACAATGTTGATTCTGAT
GACCTCATTAGCATGGGATCCAACGACATTGAGGTACTAAAGAAAATTGACATTCCATCTGTCTTTATTGGTGAATCATCAGCTAATTCT
CTGAAAGATGAATTCACATATGAAAAAGGGGGCCACCTTATCTTAGTTCCAGAATTTAGTCTTCCTTTGGAATACTACCTAATTCCCTTC
CTTATCATAGTGGGCATCTGTCTCATCTTGATAGTCATTTTCATGATCACAAAATTTGTCCAGGATAGACATAGAGCTAGAAGAAACAGA
CTTCGTAAAGATCAACTTAAGAAACTTCCTGTACATAAATTCAAGAAAGGAGATGAGTATGATGTATGTGCCATTTGTTTGGATGAGTAT
GAAGATGGAGACAAACTCAGAATCCTTCCCTGTTCCCATGCTTATCACTGCAAGTGTGTAGACCCTTGGCTAACTAAAACCAAAAAAACC
TGTCCAGTGTGCAAGCAAAAAGTTGTTCCTTCTCAAGGCGATTCAGACTCTGACACAGACAGTAGTCAAGAAGAAAATGAAGTGACAGAA
CATACCCCTTTACTGAGACCTTTAGCTTCTGTCAGTGCCCAGTCATTTGGGGCTTTATCGGAATCCCGCTCACATCAGAACATGACAGAA
TCTTCAGACTATGAGGAAGACGACAATGAAGATACTGACAGTAGTGATGCAGAAAATGAAATTAATGAACATGATGTCGTGGTCCAGTTG
CAGCCTAATGGTGAACGGGATTACAACATAGCAAATACTGTTTGACTTTCAGAAGATGATTGGTTTATTTCCCTTTAAAATGATTAGGTA
TATACTGTAATTTGATTTTTTGCTCCCTTCAAAGATTTCTGTAGAAATAACTTATTTTTTAGTATTCTACAGTTTAATCAAATTACTGAA
ACAGGACTTTTGATCTGGTATTTATCTGCCAAGAATATACTTCATTCACTAATAATAGACTGGTGCTGTAACTCAAGCATCAATTCAGCT
CTTCTTTTGGAATGAAAGTATAGCCAAAACATAAAAAAAAAAAAATCCTCAGTATAGCTTGCAATTAAGACCTAGATCACAGTATTTAAG
TGTTTTGCGTTTTATACATGAGGTCAGTGCTACAGCCACCTAGCATGAACTAACCCAGCTTCCACCTCCATAAAGTTACCTAGAGTTGTT
GAGTTGGAATATGTTCTGGCATTTACCTGACCTGCCAATCATTAGGGAGAGGCAACAAGGTAATTCAGCCTTTCCTCCTATCAGCACAAA
GAAACTCAAAGCTGTTTTTTCCCTTTCTGTTCCAAAGCAGTCTTATCCTGACAGGAGCGGTCTATACTAGTGCAGATTTCAACACTTTTT
TTTAACGTTTTAATTACTATAGTGTTATGTAGAGATTTGATTGAGCAGCTAATGTTTCTGAACTTTACTTACTAATTTTCAGTGTCCTTA
AGGGTTCTGTAGTGTTATCAAAGCAAAAAGAAAATGCTGCATAAAAATACCAAACTTCAGCAACTGTTAATACTCAGATCATATACCTCT
TAATAAATAGCATCTTATGCTAATTAGCCCTGCTAAACTATGTACAGAGGAAACTGTTCAAGTATTGGATTTGAAAGTAAGTGACTTATG
TTTAACAGAACTAATGATGTATTGAAACACTGTATTATGAAAAGCTAAATTATACATCATTGTAACTATGTAGAAAGTGTAGACTAATGT
ATAATCAAAATGCTAAGGATTTTTATATGGCCTTGTATGAGGGGAGTTTGAATGTTAATAAACATGTTTTCCA

>1461_1461_1_ACPP-RNF13_ACPP_chr3_132036420_ENST00000336375_RNF13_chr3_149613260_ENST00000344229_length(amino acids)=322AA_BP=48
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVF
IGESSANSLKDEFTYEKGGHLILVPEFSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRARRNRLRKDQLKKLPVHKFKKGDEYDV
CAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSDTDSSQEENEVTEHTPLLRPLASVSAQSFGALSES
RSHQNMTESSDYEEDDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV

--------------------------------------------------------------
>1461_1461_2_ACPP-RNF13_ACPP_chr3_132036420_ENST00000336375_RNF13_chr3_149613260_ENST00000392894_length(transcript)=2070nt_BP=210nt
TCAATCCCTTAATTAAATAGCTTCCCCTCTACAGGCTTTTGAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAAC
ATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCCTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTA
CTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTTTTAAATGCACAGAGAGCAGGATACAAGGCAGCCATAGTTCACAATGTTGATTCTGAT
GACCTCATTAGCATGGGATCCAACGACATTGAGGTACTAAAGAAAATTGACATTCCATCTGTCTTTATTGGTGAATCATCAGCTAATTCT
CTGAAAGATGAATTCACATATGAAAAAGGGGGCCACCTTATCTTAGTTCCAGAATTTAGTCTTCCTTTGGAATACTACCTAATTCCCTTC
CTTATCATAGTGGGCATCTGTCTCATCTTGATAGTCATTTTCATGATCACAAAATTTGTCCAGGATAGACATAGAGCTAGAAGAAACAGA
CTTCGTAAAGATCAACTTAAGAAACTTCCTGTACATAAATTCAAGAAAGGAGATGAGTATGATGTATGTGCCATTTGTTTGGATGAGTAT
GAAGATGGAGACAAACTCAGAATCCTTCCCTGTTCCCATGCTTATCACTGCAAGTGTGTAGACCCTTGGCTAACTAAAACCAAAAAAACC
TGTCCAGTGTGCAAGCAAAAAGTTGTTCCTTCTCAAGGCGATTCAGACTCTGACACAGACAGTAGTCAAGAAGAAAATGAAGTGACAGAA
CATACCCCTTTACTGAGACCTTTAGCTTCTGTCAGTGCCCAGTCATTTGGGGCTTTATCGGAATCCCGCTCACATCAGAACATGACAGAA
TCTTCAGACTATGAGGAAGACGACAATGAAGATACTGACAGTAGTGATGCAGAAAATGAAATTAATGAACATGATGTCGTGGTCCAGTTG
CAGCCTAATGGTGAACGGGATTACAACATAGCAAATACTGTTTGACTTTCAGAAGATGATTGGTTTATTTCCCTTTAAAATGATTAGGTA
TATACTGTAATTTGATTTTTTGCTCCCTTCAAAGATTTCTGTAGAAATAACTTATTTTTTAGTATTCTACAGTTTAATCAAATTACTGAA
ACAGGACTTTTGATCTGGTATTTATCTGCCAAGAATATACTTCATTCACTAATAATAGACTGGTGCTGTAACTCAAGCATCAATTCAGCT
CTTCTTTTGGAATGAAAGTATAGCCAAAACATAAAAAAAAAAAAATCCTCAGTATAGCTTGCAATTAAGACCTAGATCACAGTATTTAAG
TGTTTTGCGTTTTATACATGAGGTCAGTGCTACAGCCACCTAGCATGAACTAACCCAGCTTCCACCTCCATAAAGTTACCTAGAGTTGTT
GAGTTGGAATATGTTCTGGCATTTACCTGACCTGCCAATCATTAGGGAGAGGCAACAAGGTAATTCAGCCTTTCCTCCTATCAGCACAAA
GAAACTCAAAGCTGTTTTTTCCCTTTCTGTTCCAAAGCAGTCTTATCCTGACAGGAGCGGTCTATACTAGTGCAGATTTCAACACTTTTT
TTTAACGTTTTAATTACTATAGTGTTATGTAGAGATTTGATTGAGCAGCTAATGTTTCTGAACTTTACTTACTAATTTTCAGTGTCCTTA
AGGGTTCTGTAGTGTTATCAAAGCAAAAAGAAAATGCTGCATAAAAATACCAAACTTCAGCAACTGTTAATACTCAGATCATATACCTCT
TAATAAATAGCATCTTATGCTAATTAGCCCTGCTAAACTATGTACAGAGGAAACTGTTCAAGTATTGGATTTGAAAGTAAGTGACTTATG
TTTAACAGAACTAATGATGTATTGAAACACTGTATTATGAAAAGCTAAATTATACATCATTGTAACTATGTAGAAAGTGTAGACTAATGT
ATAATCAAAATGCTAAGGATTTTTATATGGCCTTGTATGAGGGGAGTTTGAATGTTAATAAACATGTTTTCCACTTTAAGATCCAGTAAA


>1461_1461_2_ACPP-RNF13_ACPP_chr3_132036420_ENST00000336375_RNF13_chr3_149613260_ENST00000392894_length(amino acids)=322AA_BP=48
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVF
IGESSANSLKDEFTYEKGGHLILVPEFSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRARRNRLRKDQLKKLPVHKFKKGDEYDV
CAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSDTDSSQEENEVTEHTPLLRPLASVSAQSFGALSES
RSHQNMTESSDYEEDDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV

--------------------------------------------------------------
>1461_1461_3_ACPP-RNF13_ACPP_chr3_132036420_ENST00000351273_RNF13_chr3_149613260_ENST00000344229_length(transcript)=2013nt_BP=170nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTTTTAAATG
CACAGAGAGCAGGATACAAGGCAGCCATAGTTCACAATGTTGATTCTGATGACCTCATTAGCATGGGATCCAACGACATTGAGGTACTAA
AGAAAATTGACATTCCATCTGTCTTTATTGGTGAATCATCAGCTAATTCTCTGAAAGATGAATTCACATATGAAAAAGGGGGCCACCTTA
TCTTAGTTCCAGAATTTAGTCTTCCTTTGGAATACTACCTAATTCCCTTCCTTATCATAGTGGGCATCTGTCTCATCTTGATAGTCATTT
TCATGATCACAAAATTTGTCCAGGATAGACATAGAGCTAGAAGAAACAGACTTCGTAAAGATCAACTTAAGAAACTTCCTGTACATAAAT
TCAAGAAAGGAGATGAGTATGATGTATGTGCCATTTGTTTGGATGAGTATGAAGATGGAGACAAACTCAGAATCCTTCCCTGTTCCCATG
CTTATCACTGCAAGTGTGTAGACCCTTGGCTAACTAAAACCAAAAAAACCTGTCCAGTGTGCAAGCAAAAAGTTGTTCCTTCTCAAGGCG
ATTCAGACTCTGACACAGACAGTAGTCAAGAAGAAAATGAAGTGACAGAACATACCCCTTTACTGAGACCTTTAGCTTCTGTCAGTGCCC
AGTCATTTGGGGCTTTATCGGAATCCCGCTCACATCAGAACATGACAGAATCTTCAGACTATGAGGAAGACGACAATGAAGATACTGACA
GTAGTGATGCAGAAAATGAAATTAATGAACATGATGTCGTGGTCCAGTTGCAGCCTAATGGTGAACGGGATTACAACATAGCAAATACTG
TTTGACTTTCAGAAGATGATTGGTTTATTTCCCTTTAAAATGATTAGGTATATACTGTAATTTGATTTTTTGCTCCCTTCAAAGATTTCT
GTAGAAATAACTTATTTTTTAGTATTCTACAGTTTAATCAAATTACTGAAACAGGACTTTTGATCTGGTATTTATCTGCCAAGAATATAC
TTCATTCACTAATAATAGACTGGTGCTGTAACTCAAGCATCAATTCAGCTCTTCTTTTGGAATGAAAGTATAGCCAAAACATAAAAAAAA
AAAAATCCTCAGTATAGCTTGCAATTAAGACCTAGATCACAGTATTTAAGTGTTTTGCGTTTTATACATGAGGTCAGTGCTACAGCCACC
TAGCATGAACTAACCCAGCTTCCACCTCCATAAAGTTACCTAGAGTTGTTGAGTTGGAATATGTTCTGGCATTTACCTGACCTGCCAATC
ATTAGGGAGAGGCAACAAGGTAATTCAGCCTTTCCTCCTATCAGCACAAAGAAACTCAAAGCTGTTTTTTCCCTTTCTGTTCCAAAGCAG
TCTTATCCTGACAGGAGCGGTCTATACTAGTGCAGATTTCAACACTTTTTTTTAACGTTTTAATTACTATAGTGTTATGTAGAGATTTGA
TTGAGCAGCTAATGTTTCTGAACTTTACTTACTAATTTTCAGTGTCCTTAAGGGTTCTGTAGTGTTATCAAAGCAAAAAGAAAATGCTGC
ATAAAAATACCAAACTTCAGCAACTGTTAATACTCAGATCATATACCTCTTAATAAATAGCATCTTATGCTAATTAGCCCTGCTAAACTA
TGTACAGAGGAAACTGTTCAAGTATTGGATTTGAAAGTAAGTGACTTATGTTTAACAGAACTAATGATGTATTGAAACACTGTATTATGA
AAAGCTAAATTATACATCATTGTAACTATGTAGAAAGTGTAGACTAATGTATAATCAAAATGCTAAGGATTTTTATATGGCCTTGTATGA
GGGGAGTTTGAATGTTAATAAACATGTTTTCCA

>1461_1461_3_ACPP-RNF13_ACPP_chr3_132036420_ENST00000351273_RNF13_chr3_149613260_ENST00000344229_length(amino acids)=322AA_BP=48
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVF
IGESSANSLKDEFTYEKGGHLILVPEFSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRARRNRLRKDQLKKLPVHKFKKGDEYDV
CAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSDTDSSQEENEVTEHTPLLRPLASVSAQSFGALSES
RSHQNMTESSDYEEDDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV

--------------------------------------------------------------
>1461_1461_4_ACPP-RNF13_ACPP_chr3_132036420_ENST00000351273_RNF13_chr3_149613260_ENST00000392894_length(transcript)=2030nt_BP=170nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTTTTAAATG
CACAGAGAGCAGGATACAAGGCAGCCATAGTTCACAATGTTGATTCTGATGACCTCATTAGCATGGGATCCAACGACATTGAGGTACTAA
AGAAAATTGACATTCCATCTGTCTTTATTGGTGAATCATCAGCTAATTCTCTGAAAGATGAATTCACATATGAAAAAGGGGGCCACCTTA
TCTTAGTTCCAGAATTTAGTCTTCCTTTGGAATACTACCTAATTCCCTTCCTTATCATAGTGGGCATCTGTCTCATCTTGATAGTCATTT
TCATGATCACAAAATTTGTCCAGGATAGACATAGAGCTAGAAGAAACAGACTTCGTAAAGATCAACTTAAGAAACTTCCTGTACATAAAT
TCAAGAAAGGAGATGAGTATGATGTATGTGCCATTTGTTTGGATGAGTATGAAGATGGAGACAAACTCAGAATCCTTCCCTGTTCCCATG
CTTATCACTGCAAGTGTGTAGACCCTTGGCTAACTAAAACCAAAAAAACCTGTCCAGTGTGCAAGCAAAAAGTTGTTCCTTCTCAAGGCG
ATTCAGACTCTGACACAGACAGTAGTCAAGAAGAAAATGAAGTGACAGAACATACCCCTTTACTGAGACCTTTAGCTTCTGTCAGTGCCC
AGTCATTTGGGGCTTTATCGGAATCCCGCTCACATCAGAACATGACAGAATCTTCAGACTATGAGGAAGACGACAATGAAGATACTGACA
GTAGTGATGCAGAAAATGAAATTAATGAACATGATGTCGTGGTCCAGTTGCAGCCTAATGGTGAACGGGATTACAACATAGCAAATACTG
TTTGACTTTCAGAAGATGATTGGTTTATTTCCCTTTAAAATGATTAGGTATATACTGTAATTTGATTTTTTGCTCCCTTCAAAGATTTCT
GTAGAAATAACTTATTTTTTAGTATTCTACAGTTTAATCAAATTACTGAAACAGGACTTTTGATCTGGTATTTATCTGCCAAGAATATAC
TTCATTCACTAATAATAGACTGGTGCTGTAACTCAAGCATCAATTCAGCTCTTCTTTTGGAATGAAAGTATAGCCAAAACATAAAAAAAA
AAAAATCCTCAGTATAGCTTGCAATTAAGACCTAGATCACAGTATTTAAGTGTTTTGCGTTTTATACATGAGGTCAGTGCTACAGCCACC
TAGCATGAACTAACCCAGCTTCCACCTCCATAAAGTTACCTAGAGTTGTTGAGTTGGAATATGTTCTGGCATTTACCTGACCTGCCAATC
ATTAGGGAGAGGCAACAAGGTAATTCAGCCTTTCCTCCTATCAGCACAAAGAAACTCAAAGCTGTTTTTTCCCTTTCTGTTCCAAAGCAG
TCTTATCCTGACAGGAGCGGTCTATACTAGTGCAGATTTCAACACTTTTTTTTAACGTTTTAATTACTATAGTGTTATGTAGAGATTTGA
TTGAGCAGCTAATGTTTCTGAACTTTACTTACTAATTTTCAGTGTCCTTAAGGGTTCTGTAGTGTTATCAAAGCAAAAAGAAAATGCTGC
ATAAAAATACCAAACTTCAGCAACTGTTAATACTCAGATCATATACCTCTTAATAAATAGCATCTTATGCTAATTAGCCCTGCTAAACTA
TGTACAGAGGAAACTGTTCAAGTATTGGATTTGAAAGTAAGTGACTTATGTTTAACAGAACTAATGATGTATTGAAACACTGTATTATGA
AAAGCTAAATTATACATCATTGTAACTATGTAGAAAGTGTAGACTAATGTATAATCAAAATGCTAAGGATTTTTATATGGCCTTGTATGA
GGGGAGTTTGAATGTTAATAAACATGTTTTCCACTTTAAGATCCAGTAAA

>1461_1461_4_ACPP-RNF13_ACPP_chr3_132036420_ENST00000351273_RNF13_chr3_149613260_ENST00000392894_length(amino acids)=322AA_BP=48
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVF
IGESSANSLKDEFTYEKGGHLILVPEFSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRARRNRLRKDQLKKLPVHKFKKGDEYDV
CAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSDTDSSQEENEVTEHTPLLRPLASVSAQSFGALSES
RSHQNMTESSDYEEDDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV

--------------------------------------------------------------
>1461_1461_5_ACPP-RNF13_ACPP_chr3_132036420_ENST00000475741_RNF13_chr3_149613260_ENST00000344229_length(transcript)=2014nt_BP=171nt
TGAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGC
CTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTTTTAAAT
GCACAGAGAGCAGGATACAAGGCAGCCATAGTTCACAATGTTGATTCTGATGACCTCATTAGCATGGGATCCAACGACATTGAGGTACTA
AAGAAAATTGACATTCCATCTGTCTTTATTGGTGAATCATCAGCTAATTCTCTGAAAGATGAATTCACATATGAAAAAGGGGGCCACCTT
ATCTTAGTTCCAGAATTTAGTCTTCCTTTGGAATACTACCTAATTCCCTTCCTTATCATAGTGGGCATCTGTCTCATCTTGATAGTCATT
TTCATGATCACAAAATTTGTCCAGGATAGACATAGAGCTAGAAGAAACAGACTTCGTAAAGATCAACTTAAGAAACTTCCTGTACATAAA
TTCAAGAAAGGAGATGAGTATGATGTATGTGCCATTTGTTTGGATGAGTATGAAGATGGAGACAAACTCAGAATCCTTCCCTGTTCCCAT
GCTTATCACTGCAAGTGTGTAGACCCTTGGCTAACTAAAACCAAAAAAACCTGTCCAGTGTGCAAGCAAAAAGTTGTTCCTTCTCAAGGC
GATTCAGACTCTGACACAGACAGTAGTCAAGAAGAAAATGAAGTGACAGAACATACCCCTTTACTGAGACCTTTAGCTTCTGTCAGTGCC
CAGTCATTTGGGGCTTTATCGGAATCCCGCTCACATCAGAACATGACAGAATCTTCAGACTATGAGGAAGACGACAATGAAGATACTGAC
AGTAGTGATGCAGAAAATGAAATTAATGAACATGATGTCGTGGTCCAGTTGCAGCCTAATGGTGAACGGGATTACAACATAGCAAATACT
GTTTGACTTTCAGAAGATGATTGGTTTATTTCCCTTTAAAATGATTAGGTATATACTGTAATTTGATTTTTTGCTCCCTTCAAAGATTTC
TGTAGAAATAACTTATTTTTTAGTATTCTACAGTTTAATCAAATTACTGAAACAGGACTTTTGATCTGGTATTTATCTGCCAAGAATATA
CTTCATTCACTAATAATAGACTGGTGCTGTAACTCAAGCATCAATTCAGCTCTTCTTTTGGAATGAAAGTATAGCCAAAACATAAAAAAA
AAAAAATCCTCAGTATAGCTTGCAATTAAGACCTAGATCACAGTATTTAAGTGTTTTGCGTTTTATACATGAGGTCAGTGCTACAGCCAC
CTAGCATGAACTAACCCAGCTTCCACCTCCATAAAGTTACCTAGAGTTGTTGAGTTGGAATATGTTCTGGCATTTACCTGACCTGCCAAT
CATTAGGGAGAGGCAACAAGGTAATTCAGCCTTTCCTCCTATCAGCACAAAGAAACTCAAAGCTGTTTTTTCCCTTTCTGTTCCAAAGCA
GTCTTATCCTGACAGGAGCGGTCTATACTAGTGCAGATTTCAACACTTTTTTTTAACGTTTTAATTACTATAGTGTTATGTAGAGATTTG
ATTGAGCAGCTAATGTTTCTGAACTTTACTTACTAATTTTCAGTGTCCTTAAGGGTTCTGTAGTGTTATCAAAGCAAAAAGAAAATGCTG
CATAAAAATACCAAACTTCAGCAACTGTTAATACTCAGATCATATACCTCTTAATAAATAGCATCTTATGCTAATTAGCCCTGCTAAACT
ATGTACAGAGGAAACTGTTCAAGTATTGGATTTGAAAGTAAGTGACTTATGTTTAACAGAACTAATGATGTATTGAAACACTGTATTATG
AAAAGCTAAATTATACATCATTGTAACTATGTAGAAAGTGTAGACTAATGTATAATCAAAATGCTAAGGATTTTTATATGGCCTTGTATG
AGGGGAGTTTGAATGTTAATAAACATGTTTTCCA

>1461_1461_5_ACPP-RNF13_ACPP_chr3_132036420_ENST00000475741_RNF13_chr3_149613260_ENST00000344229_length(amino acids)=322AA_BP=48
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVF
IGESSANSLKDEFTYEKGGHLILVPEFSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRARRNRLRKDQLKKLPVHKFKKGDEYDV
CAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSDTDSSQEENEVTEHTPLLRPLASVSAQSFGALSES
RSHQNMTESSDYEEDDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV

--------------------------------------------------------------
>1461_1461_6_ACPP-RNF13_ACPP_chr3_132036420_ENST00000475741_RNF13_chr3_149613260_ENST00000392894_length(transcript)=2031nt_BP=171nt
TGAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGC
CTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTTTTAAAT
GCACAGAGAGCAGGATACAAGGCAGCCATAGTTCACAATGTTGATTCTGATGACCTCATTAGCATGGGATCCAACGACATTGAGGTACTA
AAGAAAATTGACATTCCATCTGTCTTTATTGGTGAATCATCAGCTAATTCTCTGAAAGATGAATTCACATATGAAAAAGGGGGCCACCTT
ATCTTAGTTCCAGAATTTAGTCTTCCTTTGGAATACTACCTAATTCCCTTCCTTATCATAGTGGGCATCTGTCTCATCTTGATAGTCATT
TTCATGATCACAAAATTTGTCCAGGATAGACATAGAGCTAGAAGAAACAGACTTCGTAAAGATCAACTTAAGAAACTTCCTGTACATAAA
TTCAAGAAAGGAGATGAGTATGATGTATGTGCCATTTGTTTGGATGAGTATGAAGATGGAGACAAACTCAGAATCCTTCCCTGTTCCCAT
GCTTATCACTGCAAGTGTGTAGACCCTTGGCTAACTAAAACCAAAAAAACCTGTCCAGTGTGCAAGCAAAAAGTTGTTCCTTCTCAAGGC
GATTCAGACTCTGACACAGACAGTAGTCAAGAAGAAAATGAAGTGACAGAACATACCCCTTTACTGAGACCTTTAGCTTCTGTCAGTGCC
CAGTCATTTGGGGCTTTATCGGAATCCCGCTCACATCAGAACATGACAGAATCTTCAGACTATGAGGAAGACGACAATGAAGATACTGAC
AGTAGTGATGCAGAAAATGAAATTAATGAACATGATGTCGTGGTCCAGTTGCAGCCTAATGGTGAACGGGATTACAACATAGCAAATACT
GTTTGACTTTCAGAAGATGATTGGTTTATTTCCCTTTAAAATGATTAGGTATATACTGTAATTTGATTTTTTGCTCCCTTCAAAGATTTC
TGTAGAAATAACTTATTTTTTAGTATTCTACAGTTTAATCAAATTACTGAAACAGGACTTTTGATCTGGTATTTATCTGCCAAGAATATA
CTTCATTCACTAATAATAGACTGGTGCTGTAACTCAAGCATCAATTCAGCTCTTCTTTTGGAATGAAAGTATAGCCAAAACATAAAAAAA
AAAAAATCCTCAGTATAGCTTGCAATTAAGACCTAGATCACAGTATTTAAGTGTTTTGCGTTTTATACATGAGGTCAGTGCTACAGCCAC
CTAGCATGAACTAACCCAGCTTCCACCTCCATAAAGTTACCTAGAGTTGTTGAGTTGGAATATGTTCTGGCATTTACCTGACCTGCCAAT
CATTAGGGAGAGGCAACAAGGTAATTCAGCCTTTCCTCCTATCAGCACAAAGAAACTCAAAGCTGTTTTTTCCCTTTCTGTTCCAAAGCA
GTCTTATCCTGACAGGAGCGGTCTATACTAGTGCAGATTTCAACACTTTTTTTTAACGTTTTAATTACTATAGTGTTATGTAGAGATTTG
ATTGAGCAGCTAATGTTTCTGAACTTTACTTACTAATTTTCAGTGTCCTTAAGGGTTCTGTAGTGTTATCAAAGCAAAAAGAAAATGCTG
CATAAAAATACCAAACTTCAGCAACTGTTAATACTCAGATCATATACCTCTTAATAAATAGCATCTTATGCTAATTAGCCCTGCTAAACT
ATGTACAGAGGAAACTGTTCAAGTATTGGATTTGAAAGTAAGTGACTTATGTTTAACAGAACTAATGATGTATTGAAACACTGTATTATG
AAAAGCTAAATTATACATCATTGTAACTATGTAGAAAGTGTAGACTAATGTATAATCAAAATGCTAAGGATTTTTATATGGCCTTGTATG
AGGGGAGTTTGAATGTTAATAAACATGTTTTCCACTTTAAGATCCAGTAAA

>1461_1461_6_ACPP-RNF13_ACPP_chr3_132036420_ENST00000475741_RNF13_chr3_149613260_ENST00000392894_length(amino acids)=322AA_BP=48
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVF
IGESSANSLKDEFTYEKGGHLILVPEFSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRARRNRLRKDQLKKLPVHKFKKGDEYDV
CAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSDTDSSQEENEVTEHTPLLRPLASVSAQSFGALSES
RSHQNMTESSDYEEDDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACPP-RNF13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACPP-RNF13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACPP-RNF13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0015544Failure to Thrive1GENOMICS_ENGLAND
TgeneC0018784Sensorineural Hearing Loss (disorder)1GENOMICS_ENGLAND
TgeneC0036572Seizures1GENOMICS_ENGLAND
TgeneC0232466Feeding difficulties1GENOMICS_ENGLAND
TgeneC0234398Visual Cortex Disorder1GENOMICS_ENGLAND
TgeneC0557874Global developmental delay1GENOMICS_ENGLAND
TgeneC0852413Abnormal muscle tone1GENOMICS_ENGLAND
TgeneC2677180Congenital microcephaly1GENOMICS_ENGLAND
TgeneC3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneC4048268Cortical visual impairment1GENOMICS_ENGLAND