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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:ACPP-NEDD4L (FusionGDB2 ID:HG55TG23327)

Fusion Gene Summary for ACPP-NEDD4L

Fusion gene summary

Fusion gene information	Fusion gene name: ACPP-NEDD4L
	Fusion gene ID: hg55tg23327
		Hgene	Tgene
	Gene symbol	ACPP	NEDD4L
	Gene ID	55	23327
	Gene name	acid phosphatase 3	NEDD4 like E3 ubiquitin protein ligase
	Synonyms	5'-NT\|ACP-3\|ACPP\|TM-PAP	NEDD4-2\|NEDD4.2\|PVNH7\|RSP5\|hNEDD4-2
	Cytomap	('ACPP')('NEDD4L') 3q22.1	18q21.31
	Type of gene	protein-coding	protein-coding
	Description	prostatic acid phosphataseTMPaseacid phosphatase, prostateecto-5'-nucleotidaseprostatic acid phosphotasethiamine monophosphatase	E3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseubiquitin-protein ligase Rsp5
	Modification date	20200313	20200329
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000336375, ENST00000351273, ENST00000475741, ENST00000489084,
Fusion gene scores	* DoF score	28 X 17 X 4=1904	27 X 28 X 6=4536
	# samples	31	32
	** MAII score	log2(31/1904*10)=-2.61869335803371 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(32/4536*10)=-3.82527683005487 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ACPP [Title/Abstract] AND NEDD4L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ACPP(132056398)-NEDD4L(55833020), # samples:1
Anticipated loss of major functional domain due to fusion event.	ACPP-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACPP-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACPP-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACPP-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ACPP	GO:0046085	adenosine metabolic process	18940592
Tgene	NEDD4L	GO:0003254	regulation of membrane depolarization	15217910
Tgene	NEDD4L	GO:0006511	ubiquitin-dependent protein catabolic process	21463633
Tgene	NEDD4L	GO:0010038	response to metal ion	11244092
Tgene	NEDD4L	GO:0016567	protein ubiquitination	15217910\|25631046
Tgene	NEDD4L	GO:0034765	regulation of ion transmembrane transport	17289006
Tgene	NEDD4L	GO:0042391	regulation of membrane potential	17289006
Tgene	NEDD4L	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21463633
Tgene	NEDD4L	GO:0060306	regulation of membrane repolarization	21463633
Tgene	NEDD4L	GO:0070936	protein K48-linked ubiquitination	21463633
Tgene	NEDD4L	GO:1901016	regulation of potassium ion transmembrane transporter activity	17289006
Tgene	NEDD4L	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	21463633
Tgene	NEDD4L	GO:1901380	negative regulation of potassium ion transmembrane transport	21463633
Tgene	NEDD4L	GO:1902306	negative regulation of sodium ion transmembrane transport	15217910
Tgene	NEDD4L	GO:1903861	positive regulation of dendrite extension	23999003
Tgene	NEDD4L	GO:2000009	negative regulation of protein localization to cell surface	21463633
Tgene	NEDD4L	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	15217910

Fusion gene breakpoints across ACPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NEDD4L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-HC-7210-01A	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+

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Fusion Gene ORF analysis for ACPP-NEDD4L

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000336375	ENST00000588516	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-3UTR	ENST00000351273	ENST00000588516	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-5UTR	ENST00000336375	ENST00000256830	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-5UTR	ENST00000336375	ENST00000256832	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-5UTR	ENST00000336375	ENST00000357895	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-5UTR	ENST00000336375	ENST00000382850	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-5UTR	ENST00000336375	ENST00000435432	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-5UTR	ENST00000336375	ENST00000456986	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-5UTR	ENST00000336375	ENST00000586263	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-5UTR	ENST00000351273	ENST00000256830	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-5UTR	ENST00000351273	ENST00000256832	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-5UTR	ENST00000351273	ENST00000357895	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-5UTR	ENST00000351273	ENST00000382850	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-5UTR	ENST00000351273	ENST00000435432	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-5UTR	ENST00000351273	ENST00000456986	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-5UTR	ENST00000351273	ENST00000586263	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-intron	ENST00000336375	ENST00000431212	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-intron	ENST00000336375	ENST00000456173	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-intron	ENST00000336375	ENST00000589054	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-intron	ENST00000351273	ENST00000431212	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-intron	ENST00000351273	ENST00000456173	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
5CDS-intron	ENST00000351273	ENST00000589054	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
In-frame	ENST00000336375	ENST00000356462	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
In-frame	ENST00000336375	ENST00000400345	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
In-frame	ENST00000351273	ENST00000356462	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
In-frame	ENST00000351273	ENST00000400345	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-3CDS	ENST00000475741	ENST00000356462	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-3CDS	ENST00000475741	ENST00000400345	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-3CDS	ENST00000489084	ENST00000356462	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-3CDS	ENST00000489084	ENST00000400345	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-3UTR	ENST00000475741	ENST00000588516	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-3UTR	ENST00000489084	ENST00000588516	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-5UTR	ENST00000475741	ENST00000256830	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-5UTR	ENST00000475741	ENST00000256832	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-5UTR	ENST00000475741	ENST00000357895	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-5UTR	ENST00000475741	ENST00000382850	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-5UTR	ENST00000475741	ENST00000435432	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-5UTR	ENST00000475741	ENST00000456986	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-5UTR	ENST00000475741	ENST00000586263	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-5UTR	ENST00000489084	ENST00000256830	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-5UTR	ENST00000489084	ENST00000256832	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-5UTR	ENST00000489084	ENST00000357895	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-5UTR	ENST00000489084	ENST00000382850	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-5UTR	ENST00000489084	ENST00000435432	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-5UTR	ENST00000489084	ENST00000456986	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-5UTR	ENST00000489084	ENST00000586263	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-intron	ENST00000475741	ENST00000431212	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-intron	ENST00000475741	ENST00000456173	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-intron	ENST00000475741	ENST00000589054	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-intron	ENST00000489084	ENST00000431212	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-intron	ENST00000489084	ENST00000456173	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+
intron-intron	ENST00000489084	ENST00000589054	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000336375

ACPP

chr3

132056398

ENST00000356462

NEDD4L

chr18

55833020

3638

645

3332

1088

ENST00000336375

ACPP

chr3

132056398

ENST00000400345

NEDD4L

chr18

55833020

3961

645

3524

1152

ENST00000351273

ACPP

chr3

132056398

ENST00000356462

NEDD4L

chr18

55833020

3598

605

3292

1088

ENST00000351273

ACPP

chr3

132056398

ENST00000400345

NEDD4L

chr18

55833020

3921

605

3484

1152

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000336375	ENST00000356462	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+	0.000589111	0.99941087
ENST00000336375	ENST00000400345	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+	0.000309533	0.99969053
ENST00000351273	ENST00000356462	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+	0.000625722	0.99937433
ENST00000351273	ENST00000400345	ACPP	chr3	132056398	+	NEDD4L	chr18	55833020	+	0.000323703	0.99967635

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Fusion Genomic Features for ACPP-NEDD4L

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ACPP	chr3	132056398	+	NEDD4L	chr18	55833019	+	0.00028751	0.9997124
ACPP	chr3	132056398	+	NEDD4L	chr18	55833019	+	0.00028751	0.9997124

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACPP-NEDD4L

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:132056398/chr18:55833020)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000256830

193_226

872.0

Domain

WW 1

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000256830

385_418

872.0

Domain

WW 2

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000256830

497_530

872.0

Domain

WW 3

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000256830

548_581

872.0

Domain

WW 4

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000256830

640_974

872.0

Domain

HECT

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000356462

193_226

912.0

Domain

WW 1

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000356462

385_418

912.0

Domain

WW 2

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000356462

497_530

912.0

Domain

WW 3

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000356462

548_581

912.0

Domain

WW 4

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000356462

640_974

912.0

Domain

HECT

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000357895

193_226

968.0

Domain

WW 1

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000357895

385_418

968.0

Domain

WW 2

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000357895

497_530

968.0

Domain

WW 3

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000357895

548_581

968.0

Domain

WW 4

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000357895

640_974

968.0

Domain

HECT

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000382850

193_226

956.0

Domain

WW 1

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000382850

385_418

956.0

Domain

WW 2

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000382850

497_530

956.0

Domain

WW 3

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000382850

548_581

956.0

Domain

WW 4

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000382850

640_974

956.0

Domain

HECT

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000400345

193_226

976.0

Domain

WW 1

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000400345

385_418

976.0

Domain

WW 2

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000400345

497_530

976.0

Domain

WW 3

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000400345

548_581

976.0

Domain

WW 4

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000400345

640_974

976.0

Domain

HECT

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000431212

193_226

855.0

Domain

WW 1

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000431212

385_418

855.0

Domain

WW 2

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000431212

497_530

855.0

Domain

WW 3

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000431212

4_126

855.0

Domain

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000431212

548_581

855.0

Domain

WW 4

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000431212

640_974

855.0

Domain

HECT

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000435432

193_226

835.0

Domain

WW 1

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000435432

385_418

835.0

Domain

WW 2

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000435432

497_530

835.0

Domain

WW 3

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000435432

4_126

835.0

Domain

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000435432

548_581

835.0

Domain

WW 4

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000435432

640_974

835.0

Domain

HECT

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000456173

193_226

835.0

Domain

WW 1

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000456173

385_418

835.0

Domain

WW 2

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000456173

497_530

835.0

Domain

WW 3

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000456173

4_126

835.0

Domain

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000456173

548_581

835.0

Domain

WW 4

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000456173

640_974

835.0

Domain

HECT

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000456986

193_226

855.0

Domain

WW 1

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000456986

385_418

855.0

Domain

WW 2

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000456986

497_530

855.0

Domain

WW 3

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000456986

4_126

855.0

Domain

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000456986

548_581

855.0

Domain

WW 4

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000456986

640_974

855.0

Domain

HECT

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000586263

193_226

948.0

Domain

WW 1

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000586263

385_418

948.0

Domain

WW 2

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000586263

497_530

948.0

Domain

WW 3

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000586263

548_581

948.0

Domain

WW 4

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000586263

640_974

948.0

Domain

HECT

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000256830

4_126

872.0

Domain

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000356462

4_126

912.0

Domain

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000357895

4_126

968.0

Domain

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000382850

4_126

956.0

Domain

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000400345

4_126

976.0

Domain

Tgene

NEDD4L

chr3:132056398

chr18:55833020

ENST00000586263

4_126

948.0

Domain

Top

Fusion Gene Sequence for ACPP-NEDD4L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>1455_1455_1_ACPP-NEDD4L_ACPP_chr3_132056398_ENST00000336375_NEDD4L_chr18_55833020_ENST00000356462_length(transcript)=3638nt_BP=645nt
TCAATCCCTTAATTAAATAGCTTCCCCTCTACAGGCTTTTGAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAAC
ATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCCTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTA
CTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGCATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAA
TCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGGGCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGA
AAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATATTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTG
GCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATCCTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAA
GATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTTTTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGG
CTGCACCCTTATAAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTTGGAGCCAGT
GATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTGGTCCAGACAAAAACAATTAAAAAGACACTGAAC
CCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGACACGA
GACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGATCCAACCATGGAGCGACCCTATACATTTAAGGACTTT
CTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAA
GAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGACTCGGCTTCTCAGCACCAAGAGGAACTTCCT
CCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGG
CACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAACCAGGAGGCAGCACACCGGCGCTTCCGCTCC
CGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAAT
ATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCAGAGGAACTA
AGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGC
AGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCAT
CTAATCGAGCCTCAGATCCGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCC
GTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACA
CAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGG
GAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAA
GAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCT
ATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCC
AATAGGTTTGAAATGAAACTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAA
GCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATG
TTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACGGACAACTACACCCTTCAGATCAACCCTAATTCAGGCCTCTGTAATGAGGAT
CATTTGTCCTACTTCACTTTTATTGGAAGAGTTGCTGGTCTGGCCGTATTTCATGGGAAGCTCTTAGATGGTTTCTTCATTAGACCATTT
TACAAGATGATGTTGGGAAAGCAGATAACCCTGAATGACATGGAATCTGTGGATAGTGAATATTACAACTCTTTGAAATGGATCCTGGAG
AATGACCCTACTGAGCTGGACCTCATGTTCTGCATAGACGAAGAAAACTTTGGACAGACATATCAAGTGGATTTGAAGCCCAATGGGTCA
GAAATAATGGTCACAAATGAAAACAAAAGGGAATATATCGACTTAGTCATCCAGTGGAGATTTGTGAACAGGGTCCAGAAGCAGATGAAC
GCCTTCTTGGAGGGATTCACAGAACTACTTCCTATTGATTTGATTAAAATTTTTGATGAAAATGAGCTGGAGTTGCTCATGTGCGGCCTC
GGTGATGTGGATGTGAATGACTGGAGACAGCATTCTATTTACAAGAACGGCTACTGCCCAAACCACCCCGTCATTCAGTGGTTCTGGAAG
GCTGTGCTACTCATGGACGCCGAAAAGCGTATCCGGTTACTGCAGTTTGTCACAGGGACATCGCGAGTACCTATGAATGGATTTGCCGAA
CTTTATGGTTCCAATGGTCCTCAGCTGTTTACAATAGAGCAATGGGGCAGTCCTGAGAAACTGCCCAGAGCTCACACATGCTTTAATCGC
CTTGACTTACCTCCATATGAAACCTTTGAAGATTTACGAGAGAAACTTCTCATGGCCGTGGAAAATGCTCAAGGATTTGAAGGGGTGGAT
TAAGCACCCTGTGCCTCGGGGGTGGTTGTTCTTCAAGCAAGTTCTGCTTGCACTTTTGCATTTGCCTAACAGACTTTTGCAGAGGCGATG
GCAGAGAGCAGCTGCAGGCATGGTCCCTGGAGCCGAGCCTTCACCACGCACTCGTCCAAGTTCGGATGCGGGAACCTGGTCCCAGCTTGA
GTTCCTGCCTTTCCCACCACAAATTATCAACTGGTTGATGTGTACACTAATTACATTTCAGGAGGACTTAATGCTATTTATGTTGTGCCT

>1455_1455_1_ACPP-NEDD4L_ACPP_chr3_132056398_ENST00000336375_NEDD4L_chr18_55833020_ENST00000356462_length(amino acids)=1088AA_BP=193
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEV
FDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSA
SQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPW
ETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPLAEDGASG
SATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFID
HNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKK
LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINP
NSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQ
VDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNH
PVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVEN

--------------------------------------------------------------
>1455_1455_2_ACPP-NEDD4L_ACPP_chr3_132056398_ENST00000336375_NEDD4L_chr18_55833020_ENST00000400345_length(transcript)=3961nt_BP=645nt
TCAATCCCTTAATTAAATAGCTTCCCCTCTACAGGCTTTTGAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAAC
ATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCCTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTA
CTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGCATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAA
TCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGGGCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGA
AAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATATTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTG
GCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATCCTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAA
GATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTTTTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGG
CTGCACCCTTATAAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTTGGAGCCAGT
GATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTGGTCCAGACAAAAACAATTAAAAAGACACTGAAC
CCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGACACGA
GACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGATCCAACCATGGAGCGACCCTATACATTTAAGGACTTT
CTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAA
GAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGACTCGGCTTCTCAGCACCAAGAGGAACTTCCT
CCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGG
CACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAACCAGGAGGCAGCACACCGGCGCTTCCGCTCC
CGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAAT
ATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCAGAGGAACTA
AGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGC
AGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCCAGTGCCCCAGCTGGGAGAGCGCGTTCATCAACTGTCACGGGTGGT
GAGGAACCAACGCCATCAGTGGCCTATGTACATACCACGCCGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACA
TACTATGTCAATCATAACAATCGAACCACAACTTGGACTCGACCTATCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAAC
AGTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCC
AAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAA
CACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAG
ACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCT
CCTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTG
CAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCT
GCTGATATCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCA
GATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTG
TCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACGGACAACTACACCCTTCAGATCAACCCTAATTCAGGCCTC
TGTAATGAGGATCATTTGTCCTACTTCACTTTTATTGGAAGAGTTGCTGGTCTGGCCGTATTTCATGGGAAGCTCTTAGATGGTTTCTTC
ATTAGACCATTTTACAAGATGATGTTGGGAAAGCAGATAACCCTGAATGACATGGAATCTGTGGATAGTGAATATTACAACTCTTTGAAA
TGGATCCTGGAGAATGACCCTACTGAGCTGGACCTCATGTTCTGCATAGACGAAGAAAACTTTGGACAGACATATCAAGTGGATTTGAAG
CCCAATGGGTCAGAAATAATGGTCACAAATGAAAACAAAAGGGAATATATCGACTTAGTCATCCAGTGGAGATTTGTGAACAGGGTCCAG
AAGCAGATGAACGCCTTCTTGGAGGGATTCACAGAACTACTTCCTATTGATTTGATTAAAATTTTTGATGAAAATGAGCTGGAGTTGCTC
ATGTGCGGCCTCGGTGATGTGGATGTGAATGACTGGAGACAGCATTCTATTTACAAGAACGGCTACTGCCCAAACCACCCCGTCATTCAG
TGGTTCTGGAAGGCTGTGCTACTCATGGACGCCGAAAAGCGTATCCGGTTACTGCAGTTTGTCACAGGGACATCGCGAGTACCTATGAAT
GGATTTGCCGAACTTTATGGTTCCAATGGTCCTCAGCTGTTTACAATAGAGCAATGGGGCAGTCCTGAGAAACTGCCCAGAGCTCACACA
TGCTTTAATCGCCTTGACTTACCTCCATATGAAACCTTTGAAGATTTACGAGAGAAACTTCTCATGGCCGTGGAAAATGCTCAAGGATTT
GAAGGGGTGGATTAAGCACCCTGTGCCTCGGGGGTGGTTGTTCTTCAAGCAAGTTCTGCTTGCACTTTTGCATTTGCCTAACAGACTTTT
GCAGAGGCGATGGCAGAGAGCAGCTGCAGGCATGGTCCCTGGAGCCGAGCCTTCACCACGCACTCGTCCAAGTTCGGATGCGGGAACCTG
GTCCCAGCTTGAGTTCCTGCCTTTCCCACCACAAATTATCAACTGGTTGATGTGTACACTAATTACATTTCAGGAGGACTTAATGCTATT
TATGTTGTGCCTCTGCAGGCAAAGCCCTTAATAAATATTTTACATCCTTTCTAATGACAATGAATGGAATTAATCACTCAACAGGTATAG
TATTACGACTCATGTTTACTTTTTAAAATGATTTAGACCGATTTTCAGATTTTATTTCGTTATGATTAAAGATGTCTCATGTACTTGGAA

>1455_1455_2_ACPP-NEDD4L_ACPP_chr3_132056398_ENST00000336375_NEDD4L_chr18_55833020_ENST00000400345_length(amino acids)=1152AA_BP=193
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEV
FDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSA
SQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPW
ETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRA
RSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVT
LSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLN
PNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYR
RIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFH
GKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ
WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVT

--------------------------------------------------------------
>1455_1455_3_ACPP-NEDD4L_ACPP_chr3_132056398_ENST00000351273_NEDD4L_chr18_55833020_ENST00000356462_length(transcript)=3598nt_BP=605nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGGAGAGTCCCGTATTCTCAGAGTAA
AAGTTGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTTGGAGCCAGTGATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGA
ATAGAGAACTTGCTTTGGTCCAGACAAAAACAATTAAAAAGACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCAT
CTAATCACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACC
TTCCGACAGAAGATCCAACCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGAT
TTTTGCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGG
AAGTTGTTGACTCAAATGACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACA
ATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACA
ATAACATCAGACAGATCAACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGG
AGGGCGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCAC
CGGCCTCCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAAC
AGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCAC
CGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAGCCTCAGCT
CGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGT
CCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGC
CAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAA
AGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGATC
ATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGC
AGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAACATATTTG
AAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTG
ACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACGG
ACAACTACACCCTTCAGATCAACCCTAATTCAGGCCTCTGTAATGAGGATCATTTGTCCTACTTCACTTTTATTGGAAGAGTTGCTGGTC
TGGCCGTATTTCATGGGAAGCTCTTAGATGGTTTCTTCATTAGACCATTTTACAAGATGATGTTGGGAAAGCAGATAACCCTGAATGACA
TGGAATCTGTGGATAGTGAATATTACAACTCTTTGAAATGGATCCTGGAGAATGACCCTACTGAGCTGGACCTCATGTTCTGCATAGACG
AAGAAAACTTTGGACAGACATATCAAGTGGATTTGAAGCCCAATGGGTCAGAAATAATGGTCACAAATGAAAACAAAAGGGAATATATCG
ACTTAGTCATCCAGTGGAGATTTGTGAACAGGGTCCAGAAGCAGATGAACGCCTTCTTGGAGGGATTCACAGAACTACTTCCTATTGATT
TGATTAAAATTTTTGATGAAAATGAGCTGGAGTTGCTCATGTGCGGCCTCGGTGATGTGGATGTGAATGACTGGAGACAGCATTCTATTT
ACAAGAACGGCTACTGCCCAAACCACCCCGTCATTCAGTGGTTCTGGAAGGCTGTGCTACTCATGGACGCCGAAAAGCGTATCCGGTTAC
TGCAGTTTGTCACAGGGACATCGCGAGTACCTATGAATGGATTTGCCGAACTTTATGGTTCCAATGGTCCTCAGCTGTTTACAATAGAGC
AATGGGGCAGTCCTGAGAAACTGCCCAGAGCTCACACATGCTTTAATCGCCTTGACTTACCTCCATATGAAACCTTTGAAGATTTACGAG
AGAAACTTCTCATGGCCGTGGAAAATGCTCAAGGATTTGAAGGGGTGGATTAAGCACCCTGTGCCTCGGGGGTGGTTGTTCTTCAAGCAA
GTTCTGCTTGCACTTTTGCATTTGCCTAACAGACTTTTGCAGAGGCGATGGCAGAGAGCAGCTGCAGGCATGGTCCCTGGAGCCGAGCCT
TCACCACGCACTCGTCCAAGTTCGGATGCGGGAACCTGGTCCCAGCTTGAGTTCCTGCCTTTCCCACCACAAATTATCAACTGGTTGATG

>1455_1455_3_ACPP-NEDD4L_ACPP_chr3_132056398_ENST00000351273_NEDD4L_chr18_55833020_ENST00000356462_length(amino acids)=1088AA_BP=193
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEV
FDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSA
SQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPW
ETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPLAEDGASG
SATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFID
HNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKK
LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINP
NSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQ
VDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNH
PVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVEN

--------------------------------------------------------------
>1455_1455_4_ACPP-NEDD4L_ACPP_chr3_132056398_ENST00000351273_NEDD4L_chr18_55833020_ENST00000400345_length(transcript)=3921nt_BP=605nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGGAGAGTCCCGTATTCTCAGAGTAA
AAGTTGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTTGGAGCCAGTGATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGA
ATAGAGAACTTGCTTTGGTCCAGACAAAAACAATTAAAAAGACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCAT
CTAATCACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACC
TTCCGACAGAAGATCCAACCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGAT
TTTTGCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGG
AAGTTGTTGACTCAAATGACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACA
ATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACA
ATAACATCAGACAGATCAACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGG
AGGGCGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCAC
CGGCCTCCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAAC
AGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCAC
CGCCCAGTGCCCCAGCTGGGAGAGCGCGTTCATCAACTGTCACGGGTGGTGAGGAACCAACGCCATCAGTGGCCTATGTACATACCACGC
CGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACCACAACTTGGACTC
GACCTATCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTC
GTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTT
CCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAA
TGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTAC
ATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGT
TTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCA
GAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAACTTCACAGAA
ATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAG
AGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGT
ACTCTGCCACGGACAACTACACCCTTCAGATCAACCCTAATTCAGGCCTCTGTAATGAGGATCATTTGTCCTACTTCACTTTTATTGGAA
GAGTTGCTGGTCTGGCCGTATTTCATGGGAAGCTCTTAGATGGTTTCTTCATTAGACCATTTTACAAGATGATGTTGGGAAAGCAGATAA
CCCTGAATGACATGGAATCTGTGGATAGTGAATATTACAACTCTTTGAAATGGATCCTGGAGAATGACCCTACTGAGCTGGACCTCATGT
TCTGCATAGACGAAGAAAACTTTGGACAGACATATCAAGTGGATTTGAAGCCCAATGGGTCAGAAATAATGGTCACAAATGAAAACAAAA
GGGAATATATCGACTTAGTCATCCAGTGGAGATTTGTGAACAGGGTCCAGAAGCAGATGAACGCCTTCTTGGAGGGATTCACAGAACTAC
TTCCTATTGATTTGATTAAAATTTTTGATGAAAATGAGCTGGAGTTGCTCATGTGCGGCCTCGGTGATGTGGATGTGAATGACTGGAGAC
AGCATTCTATTTACAAGAACGGCTACTGCCCAAACCACCCCGTCATTCAGTGGTTCTGGAAGGCTGTGCTACTCATGGACGCCGAAAAGC
GTATCCGGTTACTGCAGTTTGTCACAGGGACATCGCGAGTACCTATGAATGGATTTGCCGAACTTTATGGTTCCAATGGTCCTCAGCTGT
TTACAATAGAGCAATGGGGCAGTCCTGAGAAACTGCCCAGAGCTCACACATGCTTTAATCGCCTTGACTTACCTCCATATGAAACCTTTG
AAGATTTACGAGAGAAACTTCTCATGGCCGTGGAAAATGCTCAAGGATTTGAAGGGGTGGATTAAGCACCCTGTGCCTCGGGGGTGGTTG
TTCTTCAAGCAAGTTCTGCTTGCACTTTTGCATTTGCCTAACAGACTTTTGCAGAGGCGATGGCAGAGAGCAGCTGCAGGCATGGTCCCT
GGAGCCGAGCCTTCACCACGCACTCGTCCAAGTTCGGATGCGGGAACCTGGTCCCAGCTTGAGTTCCTGCCTTTCCCACCACAAATTATC
AACTGGTTGATGTGTACACTAATTACATTTCAGGAGGACTTAATGCTATTTATGTTGTGCCTCTGCAGGCAAAGCCCTTAATAAATATTT
TACATCCTTTCTAATGACAATGAATGGAATTAATCACTCAACAGGTATAGTATTACGACTCATGTTTACTTTTTAAAATGATTTAGACCG

>1455_1455_4_ACPP-NEDD4L_ACPP_chr3_132056398_ENST00000351273_NEDD4L_chr18_55833020_ENST00000400345_length(amino acids)=1152AA_BP=193
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEV
FDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSA
SQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPW
ETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRA
RSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVT
LSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLN
PNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYR
RIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFH
GKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ
WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACPP-NEDD4L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ACPP-NEDD4L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ACPP-NEDD4L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C0020538	Hypertensive disease	2	CTD_human
Tgene		C4310669	PERIVENTRICULAR NODULAR HETEROTOPIA 7	2	GENOMICS_ENGLAND;UNIPROT
Tgene		C0008925	Cleft Palate	1	CTD_human;GENOMICS_ENGLAND
Tgene		C0014175	Endometriosis	1	CTD_human
Tgene		C0039075	Syndactyly	1	CTD_human
Tgene		C0265553	Polysyndactyly	1	CTD_human
Tgene		C0269102	Endometrioma	1	CTD_human
Tgene		C0543888	Epileptic encephalopathy	1	GENOMICS_ENGLAND
Tgene		C1837218	Cleft palate, isolated	1	CTD_human
Tgene		C1848213	Periventricular Heterotopia, X-Linked	1	CTD_human
Tgene		C1868720	Periventricular Nodular Heterotopia	1	CTD_human;ORPHANET
Tgene		C4551969	Bilateral Periventricular Nodular Heterotopia	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:ACPP-NEDD4L (FusionGDB2 ID:HG55TG23327)

Fusion Gene Summary for ACPP-NEDD4L

Fusion Gene ORF analysis for ACPP-NEDD4L

Fusion Genomic Features for ACPP-NEDD4L

Fusion Protein Features for ACPP-NEDD4L

Fusion Gene Sequence for ACPP-NEDD4L

Fusion Gene PPI Analysis for ACPP-NEDD4L

Related Drugs for ACPP-NEDD4L

Related Diseases for ACPP-NEDD4L

Fusion Gene Studies
in Kim Lab