Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ACPP-AMACR (FusionGDB2 ID:HG55TG23600)

Fusion Gene Summary for ACPP-AMACR

check button Fusion gene summary
Fusion gene informationFusion gene name: ACPP-AMACR
Fusion gene ID: hg55tg23600
HgeneTgene
Gene symbol

ACPP

AMACR

Gene ID

55

23600

Gene nameacid phosphatase 3alpha-methylacyl-CoA racemase
Synonyms5'-NT|ACP-3|ACPP|TM-PAPAMACRD|CBAS4|P504S|RACE|RM
Cytomap('ACPP')('AMACR')

3q22.1

5p13.2

Type of geneprotein-codingprotein-coding
Descriptionprostatic acid phosphataseTMPaseacid phosphatase, prostateecto-5'-nucleotidaseprostatic acid phosphotasethiamine monophosphatasealpha-methylacyl-CoA racemase2-methylacyl-CoA racemase
Modification date2020031320200313
UniProtAcc.

Q9UHK6

Ensembl transtripts involved in fusion geneENST00000336375, ENST00000351273, 
ENST00000475741, ENST00000489084, 
Fusion gene scores* DoF score28 X 17 X 4=190428 X 3 X 4=336
# samples 3123
** MAII scorelog2(31/1904*10)=-2.61869335803371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/336*10)=-0.546827371834385
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACPP [Title/Abstract] AND AMACR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACPP(132075699)-AMACR(34006004), # samples:1
Anticipated loss of major functional domain due to fusion event.ACPP-AMACR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACPP-AMACR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACPP-AMACR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACPP-AMACR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACPP-AMACR seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ACPP-AMACR seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ACPP-AMACR seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACPP

GO:0046085

adenosine metabolic process

18940592

TgeneAMACR

GO:0008206

bile acid metabolic process

10655068


check buttonFusion gene breakpoints across ACPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across AMACR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A8S9ACPPchr3

132075699

+AMACRchr5

34006004

-


Top

Fusion Gene ORF analysis for ACPP-AMACR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000336375ENST00000382068ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000336375ENST00000382085ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000336375ENST00000426255ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000336375ENST00000441713ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000336375ENST00000502637ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000336375ENST00000512079ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000336375ENST00000514195ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000351273ENST00000382068ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000351273ENST00000382085ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000351273ENST00000426255ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000351273ENST00000441713ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000351273ENST00000502637ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000351273ENST00000512079ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000351273ENST00000514195ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000475741ENST00000382068ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000475741ENST00000382085ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000475741ENST00000426255ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000475741ENST00000441713ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000475741ENST00000502637ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000475741ENST00000512079ACPPchr3

132075699

+AMACRchr5

34006004

-
5CDS-5UTRENST00000475741ENST00000514195ACPPchr3

132075699

+AMACRchr5

34006004

-
Frame-shiftENST00000336375ENST00000335606ACPPchr3

132075699

+AMACRchr5

34006004

-
Frame-shiftENST00000336375ENST00000382072ACPPchr3

132075699

+AMACRchr5

34006004

-
Frame-shiftENST00000475741ENST00000335606ACPPchr3

132075699

+AMACRchr5

34006004

-
Frame-shiftENST00000475741ENST00000382072ACPPchr3

132075699

+AMACRchr5

34006004

-
In-frameENST00000351273ENST00000335606ACPPchr3

132075699

+AMACRchr5

34006004

-
In-frameENST00000351273ENST00000382072ACPPchr3

132075699

+AMACRchr5

34006004

-
intron-3CDSENST00000489084ENST00000335606ACPPchr3

132075699

+AMACRchr5

34006004

-
intron-3CDSENST00000489084ENST00000382072ACPPchr3

132075699

+AMACRchr5

34006004

-
intron-5UTRENST00000489084ENST00000382068ACPPchr3

132075699

+AMACRchr5

34006004

-
intron-5UTRENST00000489084ENST00000382085ACPPchr3

132075699

+AMACRchr5

34006004

-
intron-5UTRENST00000489084ENST00000426255ACPPchr3

132075699

+AMACRchr5

34006004

-
intron-5UTRENST00000489084ENST00000441713ACPPchr3

132075699

+AMACRchr5

34006004

-
intron-5UTRENST00000489084ENST00000502637ACPPchr3

132075699

+AMACRchr5

34006004

-
intron-5UTRENST00000489084ENST00000512079ACPPchr3

132075699

+AMACRchr5

34006004

-
intron-5UTRENST00000489084ENST00000514195ACPPchr3

132075699

+AMACRchr5

34006004

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000351273ACPPchr3132075699+ENST00000335606AMACRchr534006004-50051188262089687
ENST00000351273ACPPchr3132075699+ENST00000382072AMACRchr534006004-38481188261537503

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000351273ENST00000335606ACPPchr3132075699+AMACRchr534006004-0.0001599240.99984
ENST00000351273ENST00000382072ACPPchr3132075699+AMACRchr534006004-0.0004907540.9995092

Top

Fusion Genomic Features for ACPP-AMACR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for ACPP-AMACR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:132075699/chr5:34006004)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AMACR

Q9UHK6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:7649182, PubMed:10655068, PubMed:11060359). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:7649182, PubMed:10655068, PubMed:11060359). {ECO:0000269|PubMed:10655068, ECO:0000269|PubMed:11060359, ECO:0000269|PubMed:7649182}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAMACRchr3:132075699chr5:34006004ENST0000033560605380_38282383.0MotifMicrobody targeting signal
TgeneAMACRchr3:132075699chr5:34006004ENST0000038207204380_38282199.0MotifMicrobody targeting signal
TgeneAMACRchr3:132075699chr5:34006004ENST0000038208506380_38282395.0MotifMicrobody targeting signal
TgeneAMACRchr3:132075699chr5:34006004ENST0000044171304380_38282230.0MotifMicrobody targeting signal
TgeneAMACRchr3:132075699chr5:34006004ENST0000033560605121_12682383.0RegionSubstrate binding
TgeneAMACRchr3:132075699chr5:34006004ENST0000038207204121_12682199.0RegionSubstrate binding
TgeneAMACRchr3:132075699chr5:34006004ENST0000038208506121_12682395.0RegionSubstrate binding
TgeneAMACRchr3:132075699chr5:34006004ENST0000044171304121_12682230.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAMACRchr3:132075699chr5:34006004ENST000003356060555_5882383.0RegionSubstrate binding
TgeneAMACRchr3:132075699chr5:34006004ENST000003820720455_5882199.0RegionSubstrate binding
TgeneAMACRchr3:132075699chr5:34006004ENST000003820850655_5882395.0RegionSubstrate binding
TgeneAMACRchr3:132075699chr5:34006004ENST000004417130455_5882230.0RegionSubstrate binding


Top

Fusion Gene Sequence for ACPP-AMACR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1442_1442_1_ACPP-AMACR_ACPP_chr3_132075699_ENST00000351273_AMACR_chr5_34006004_ENST00000335606_length(transcript)=5005nt_BP=1188nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC
TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC
CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG
AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA
TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC
ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC
TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA
CCACAAACAGCCATCAAGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGC
TGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTG
GCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGG
CTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGA
AAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAG
ATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGATGAACTTCCCA
ATCAGATGAGCATGGATGATTGGCCAGAAATGAAGAAGAAGTTTGCAGATGTATTTGCAGAGAAGACGAAGGCAGAGTGGTGTCAAATCT
TTGACGGCACAGATGCCTGTGTGACTCCGGTTCTGACTTTTGAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGGCTCGTTTATCA
CCAGTGAGGAGCAGGACGTGAGCCCCCGCCCTGCACCTCTGCTGTTAAACACCCCAGCCATCCCTTCTTTCAAAAGGGATCCTTTCATAG
GAGAACACACTGAGGAGATACTTGAAGAATTTGGATTCAGCCGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCATTGAAAGTAATA
AGGTAAAAGCTAGTCTCTAACTTCCAGGCCCACGGCTCAAGTGAATTTGAATACTGCATTTACAGTGTAGAGTAACACATAACATTGTAT
GCATGGAAACATGGAGGAACAGTATTACAGTGTCCTACCACTCTAATCAAGAAAAGAATTACAGACTCTGATTCTACAGTGATGATTGAA
TTCTAAAAATGGTTATCATTAGGGCTTTTGATTTATAAAACTTTGGGTACTTATACTAAATTATGGTAGTTATTCTGCCTTCCAGTTTGC
TTGATATATTTGTTGATATTAAGATTCTTGACTTATATTTTGAATGGGTTCTAGTGAAAAAGGAATGATATATTCTTGAAGACATCGATA
TACATTTATTTACACTCTTGATTCTACAATGTAGAAAATGAGGAAATGCCACAAATTGTATGGTGATAAAAGTCACGTGAAACAGAGTGA
TTGGTTGCATCCAGGCCTTTTGTCTTGGTGTTCATGATCTCCCTCTAAGCACATTCCAAACTTTAGCAACAGTTATCACACTTTGTAATT
TGCAAAGAAAAGTTTCACCTGTATTGAATCAGAATGCCTTCAACTGAAAAAAACATATCCAAAATAATGAGGAAATGTGTTGGCTCACTA
CGTAGAGTCCAGAGGGACAGTCAGTTTTAGGGTTGCCTGTATCCAGTAACTCGGGGCCTGTTTCCCCGTGGGTCTCTGGGCTGTCAGCTT
TCCTTTCTCCATGTGTTTGATTTCTCCTCAGGCTGGTAGCAAGTTCTGGATCTTATACCCAACACACAGCAACATCCAGAAATAAAGATC
TCAGGACCCCCCAGCAAGTCGTTTTGTGTCTCCTTGGACTGAGTTAAGTTACAAGCCTTTCTTATACCTGTCTTTGACAAAGAAGACGGG
ATTGTCTTTACATAAAACCAGCCTGCTCCTGGAGCTTCCCTGGACTCAACTTCCTAAAGGCATGTGAGGAAGGGGTAGATTCCACAATCT
AATCCGGGTGCCATCAGAGTAGAGGGAGTAGAGAATGGATGTTGGGTAGGCCATCAATAAGGTCCATTCTGCGCAGTATCTCAACTGCCG
TTCAACAATCGCAAGAGGAAGGTGGAGCAGGTTTCTTCATCTTACAGTTGAGAAAACAGAGACTCAGAAGGGCTTCTTAGTTCATGTTTC
CCTTAGCGCCTCAGTGATTTTTTCATGGTGGCTTAGGCCAAAAGAAATATCTAACCATTCAATTTATAAATAATTAGGTCCCCAACGAAT
TAAATATTATGTCCTACCAACTTATTAGCTGCTTGAAAAATATAATACACATAAATAAAAAAATATATTTTTCATTTCTATTTCATTGTT
AATCACAACTACTTACTAAGGAGATGTATGCACCTATTGGACACTGTGCAACTTCTCACCTGGAATGAGATTGGACACTGCTGCCCTCAT
TTTCTGCTCCATGTTGGTGTCCATATAGTACTTGATTTTTTATCAGATGGCCTGGAAAACCCAGTCTCACAAAAATATGAAATTATCAGA
AGGATTATAGTGCAATCTTATGTTGAAAGAATGAACTACCTCACTAGTAGTTCACGTGATGTCTGACAGATGTTGAGTTTCATTGTGTTT
GTGTGTTCAAATTTTTAAATATTCTGAGATACTCTTGTGAGGTCACTCTAATGCCCTGGGTGCCTTGGCACAGTTTTAGAAATACCAGTT
GAAAATATTTGCTCAGGAATATGCAACTAGGAAGGGGCAGAATCAGAATTTAAGCTTTCATATTCTAGCCTTCAGTCTTGTTCTTCAACC
ATTTTTAGGAACTTTCCCATAAGGTTATGTTTTCCAGCCCAGGCATGGAGGATCACTTGAGGCCAAGAGTTCGAGACCAGCCTGGGGAAC
TTGGCTGGACCTCCGTTTCTACGAAATAAAAATAAAAAAATTATCCAGGTATGGTGGTGTGTGCCTGTAGTCCTATCTACTCAAGGGTGG
GGCAGGAGGATCACTTGAGCCCAGGAATTTGAGGCCACAGTGAATTAGGATTGCACCACTGCACTCTAGCCCAGGCAACAGAACAAGAAC
CTGTCTCTAAATAAATAAATAAAAATAATAATAATAAAAAAGATGTTTTCCCTACAACTCAGACTTTTCATTTGAACTCGGTCCAGCAAG
GAAAATATAACCCACTCGAAGTCTTTAAAACAGAGGAAATTTAATATAAAGAATTCCACTGGTGACGAAAGAGCAGAGAAGCCCAGAAGA
TAGTGAGGCAACCCTGATAGGAACATAACTAGGAAGCCAAGACCACTCCTATGGTTGCAGGGGTGATGGGAAAGCTGGTGTACTTGGACC
CAGAAGCCAAAGTTGCTGCACCCACCTTGGAGACATAGACACTGGCAGTAATACCTCAGGGAGAAGAAAGAAATCTAGGGAAATATCCTG
GCTTCTTTCCTTCTCTCTCTCCCCTAGTCTTCCTACCAGTGTCTCCCATTAGCCAAATCTACCTAGAAGCCAGAAAACAAGGGAACCCTG
GAAATGTAGCCCCATAAGATAAAGAGCACCAAAGGAAATAGATCTGAGCAGACAGGCAGCACAAAATGCAGTGTGTATGGTTTATTCACT
CAGTAATTCCTTTAGCAAATGTTTATTGAGGATCTACTAGGTGCCAGGTATCATGATACTTGCTGGGGATACCATAATGAACAAAACAGA
CCTGTTCTCCGCTCTTGAGGAAATCAAAGACAAACACAGGATATGGAATAAACCCAGAATTATCTCATTGTAAAATGTGTTAAGTACCAC
GAGGAGAAATATCAGGGCGATCTGACACAGCTAATGATTTGAAGAAGGGTGTGACCTGCCACCATTTTAAATCTAGTTATTTCACTCCTG

>1442_1442_1_ACPP-AMACR_ACPP_chr3_132075699_ENST00000351273_AMACR_chr5_34006004_ENST00000335606_length(amino acids)=687AA_BP=387
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCP
LERFAELVGPVIPQDWSTECMTTNSHQGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYA
PLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVIDANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGA
IEPQFYELLIKGLGLKSDELPNQMSMDDWPEMKKKFADVFAEKTKAEWCQIFDGTDACVTPVLTFEEVVHHDHNKERGSFITSEEQDVSP

--------------------------------------------------------------
>1442_1442_2_ACPP-AMACR_ACPP_chr3_132075699_ENST00000351273_AMACR_chr5_34006004_ENST00000382072_length(transcript)=3848nt_BP=1188nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC
TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC
CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG
AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA
TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC
ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC
TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA
CCACAAACAGCCATCAAGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGC
TGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGGAAGGAACAGCATAT
TTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTAT
ACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACTTGGACTA
AAGTCTGATGAACTTCCCAATCAGATGAGCATGGATGATTGGCCAGAAATGAAGAAGAAGTTTGCAGATGTATTTGCAGAGAAGACGAAG
GCAGAGTGGTGTCAAATCTTTGACGGCACAGATGCCTGTGTGACTCCGGTTCTGACTTTTGAGGAGGTTGTTCATCATGATCACAACAAG
GAACGGGGCTCGTTTATCACCAGTGAGGAGCAGGACGTGAGCCCCCGCCCTGCACCTCTGCTGTTAAACACCCCAGCCATCCCTTCTTTC
AAAAGGGATCCTTTCATAGGAGAACACACTGAGGAGATACTTGAAGAATTTGGATTCAGCCGCGAAGAGATTTATCAGCTTAACTCAGAT
AAAATCATTGAAAGTAATAAGGTAAAAGCTAGTCTCTAACTTCCAGGCCCACGGCTCAAGTGAATTTGAATACTGCATTTACAGTGTAGA
GTAACACATAACATTGTATGCATGGAAACATGGAGGAACAGTATTACAGTGTCCTACCACTCTAATCAAGAAAAGAATTACAGACTCTGA
TTCTACAGTGATGATTGAATTCTAAAAATGGTTATCATTAGGGCTTTTGATTTATAAAACTTTGGGTACTTATACTAAATTATGGTAGTT
ATTCTGCCTTCCAGTTTGCTTGATATATTTGTTGATATTAAGATTCTTGACTTATATTTTGAATGGGTTCTAGTGAAAAAGGAATGATAT
ATTCTTGAAGACATCGATATACATTTATTTACACTCTTGATTCTACAATGTAGAAAATGAGGAAATGCCACAAATTGTATGGTGATAAAA
GTCACGTGAAACAGAGTGATTGGTTGCATCCAGGCCTTTTGTCTTGGTGTTCATGATCTCCCTCTAAGCACATTCCAAACTTTAGCAACA
GTTATCACACTTTGTAATTTGCAAAGAAAAGTTTCACCTGTATTGAATCAGAATGCCTTCAACTGAAAAAAACATATCCAAAATAATGAG
GAAATGTGTTGGCTCACTACGTAGAGTCCAGAGGGACAGTCAGTTTTAGGGTTGCCTGTATCCAGTAACTCGGGGCCTGTTTCCCCGTGG
GTCTCTGGGCTGTCAGCTTTCCTTTCTCCATGTGTTTGATTTCTCCTCAGGCTGGTAGCAAGTTCTGGATCTTATACCCAACACACAGCA
ACATCCAGAAATAAAGATCTCAGGACCCCCCAGCAAGTCGTTTTGTGTCTCCTTGGACTGAGTTAAGTTACAAGCCTTTCTTATACCTGT
CTTTGACAAAGAAGACGGGATTGTCTTTACATAAAACCAGCCTGCTCCTGGAGCTTCCCTGGACTCAACTTCCTAAAGGCATGTGAGGAA
GGGGTAGATTCCACAATCTAATCCGGGTGCCATCAGAGTAGAGGGAGTAGAGAATGGATGTTGGGTAGGCCATCAATAAGGTCCATTCTG
CGCAGTATCTCAACTGCCGTTCAACAATCGCAAGAGGAAGGTGGAGCAGGTTTCTTCATCTTACAGTTGAGAAAACAGAGACTCAGAAGG
GCTTCTTAGTTCATGTTTCCCTTAGCGCCTCAGTGATTTTTTCATGGTGGCTTAGGCCAAAAGAAATATCTAACCATTCAATTTATAAAT
AATTAGGTCCCCAACGAATTAAATATTATGTCCTACCAACTTATTAGCTGCTTGAAAAATATAATACACATAAATAAAAAAATATATTTT
TCATTTCTATTTCATTGTTAATCACAACTACTTACTAAGGAGATGTATGCACCTATTGGACACTGTGCAACTTCTCACCTGGAATGAGAT
TGGACACTGCTGCCCTCATTTTCTGCTCCATGTTGGTGTCCATATAGTACTTGATTTTTTATCAGATGGCCTGGAAAACCCAGTCTCACA
AAAATATGAAATTATCAGAAGGATTATAGTGCAATCTTATGTTGAAAGAATGAACTACCTCACTAGTAGTTCACGTGATGTCTGACAGAT
GTTGAGTTTCATTGTGTTTGTGTGTTCAAATTTTTAAATATTCTGAGATACTCTTGTGAGGTCACTCTAATGCCCTGGGTGCCTTGGCAC
AGTTTTAGAAATACCAGTTGAAAATATTTGCTCAGGAATATGCAACTAGGAAGGGGCAGAATCAGAATTTAAGCTTTCATATTCTAGCCT
TCAGTCTTGTTCTTCAACCATTTTTAGGAACTTTCCCATAAGGTTATGTTTTCCAGCCCAGGCATGGAGGATCACTTGAGGCCAAGAGTT

>1442_1442_2_ACPP-AMACR_ACPP_chr3_132075699_ENST00000351273_AMACR_chr5_34006004_ENST00000382072_length(amino acids)=503AA_BP=387
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCP
LERFAELVGPVIPQDWSTECMTTNSHQGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGGRNSIFKFFSVENS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ACPP-AMACR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ACPP-AMACR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ACPP-AMACR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0033578Prostatic Neoplasms3CTD_human
TgeneC0376358Malignant neoplasm of prostate3CTD_human
TgeneC1858328Bile acid synthesis defect, congenital, 43CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC3280428Alpha-Methylacyl-CoA Racemase Deficiency3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0023893Liver Cirrhosis, Experimental2CTD_human
TgeneC0001430Adenoma1CTD_human
TgeneC0009402Colorectal Carcinoma1CTD_human
TgeneC0009404Colorectal Neoplasms1CTD_human
TgeneC0011195Dejerine-Sottas Disease (disorder)1CTD_human
TgeneC0019816Hereditary, Type VII, Motor and Sensory Neuropathy1CTD_human
TgeneC0023895Liver diseases1CTD_human
TgeneC0027888Hereditary Motor and Sensory Neuropathies1CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0086565Liver Dysfunction1CTD_human
TgeneC0205646Adenoma, Basal Cell1CTD_human
TgeneC0205647Follicular adenoma1CTD_human
TgeneC0205648Adenoma, Microcystic1CTD_human
TgeneC0205649Adenoma, Monomorphic1CTD_human
TgeneC0205650Papillary adenoma1CTD_human
TgeneC0205651Adenoma, Trabecular1CTD_human